TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T79031	Beta-secretase 1	D0Y5NA	PF-06751979	Phase 1	118435360	C18H19F2N5O3S2	455.5	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B02MTN	N,N''-(2-Hydroxypropane-1,3-diyl)bis(2-benzamidobenzamide)	Investigative	3718101	C31H28N4O5	536.6	C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)NCC(CNC(=O)C3=CC=CC=C3NC(=O)C4=CC=CC=C4)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B03JHU	C1OCC(N)=NC21C1(COC1)COC1=CC=C(Br)C=C12	Investigative	90056198	C14H15BrN2O3	339.18	C1C(=NC2(CO1)C3=C(C=CC(=C3)Br)OCC24COC4)N	IC50 = 68300 nM	Poor binder
T79031	Beta-secretase 1	B04ZCO	3-(Benzylsulfanyl)-6-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6,7-dihydro[1,2,4]triazino[5,6-d][3,1]benzoxazepine	Investigative	6411782	C27H21ClN6OS	513	CC1=NN(C(=C1C2NC3=CC=CC=C3C4=C(O2)N=C(N=N4)SCC5=CC=CC=C5)Cl)C6=CC=CC=C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B0J8IS	N-[(2S)-5-(Diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(2-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]benzamide;2,2,2-trifluoroacetic acid	Investigative	118717662	C34H48F3N7O7	723.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B0L1NE	3-[(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]-N-(4-fluorobenzyl)-4-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)benzamide	Investigative	46371748	C33H31FN4O6S	630.7	C1COC2=C(O1)C=CC(=C2)S(=O)(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC=C(C=C4)F)N5CC6CC(C5)C7=CC=CC(=O)N7C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B0MA5D	Chembl4209994	Investigative	145966369	C15H17F3N2OS	330.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3C(F)(F)F)N	IC50 ~ 79300 nM	Poor binder
T79031	Beta-secretase 1	B0SR7W	2-{[3-Cyano-6-(4-fluorophenyl)-4-phenyl-2-pyridinyl]sulfanyl}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide	Investigative	1717763	C24H18FN5OS2	475.6	CCC1=NN=C(S1)NC(=O)CSC2=C(C(=CC(=N2)C3=CC=C(C=C3)F)C4=CC=CC=C4)C#N	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B0XUW1	(1-Methoxycarbonylpiperidin-4-yl) (2'R,3S)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxylate	Investigative	71450318	C19H23N3O5	373.4	COC(=O)N1CCC(CC1)OC(=O)[C@H]2C[C@@]3(CN2)C4=CC=CC=C4NC3=O	IC50 = 83700 nM	Poor binder
T79031	Beta-secretase 1	B0Y7OQ	(6S)-2-Amino-3,6-dimethyl-6-[(1S,2S)-2-phenylcyclopropyl]-5H-pyrimidin-4-one;2,2,2-trifluoroacetic acid	Investigative	72205116	C17H20F3N3O3	371.35	C[C@]1(CC(=O)N(C(=N1)N)C)[C@H]2C[C@@H]2C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 = 132000 nM	Poor binder
T79031	Beta-secretase 1	B10KHL	2-Amino-6-[3-(3-methoxyphenyl)phenyl]-3,6-dimethyl-5H-pyrimidin-4-one	Investigative	11594966	C19H21N3O2	323.4	CC1(CC(=O)N(C(=N1)N)C)C2=CC=CC(=C2)C3=CC(=CC=C3)OC	IC50 = 91000 nM	Poor binder
T79031	Beta-secretase 1	B17FPC	4-(2-Amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-isopropylbutanamide	Investigative	49864506	C14H19ClN4O	294.78	CC(C)NC(=O)CCCN1C2=C(C=C(C=C2)Cl)N=C1N	IC50 = 193000 nM	Poor binder
T79031	Beta-secretase 1	B17MZC	2-Amino-3-methyl-6-[2-[3-(1H-pyrrol-2-yl)phenyl]ethyl]pyrimidin-4-one	Investigative	11673750	C17H18N4O	294.35	CN1C(=O)C=C(N=C1N)CCC2=CC(=CC=C2)C3=CC=CN3	IC50 = 51000 nM	Poor binder
T79031	Beta-secretase 1	B1BYP9	N-(2-Chlorophenyl)-2-({6-[(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)amino]-1,3-benzothiazol-2-yl}sulfanyl)acetamide	Investigative	4531891	C26H27ClN8O3S2	599.1	C1COCCN1C2=NC(=NC(=N2)NC3=CC4=C(C=C3)N=C(S4)SCC(=O)NC5=CC=CC=C5Cl)N6CCOCC6	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B1D7SG	3-{[(5-Aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-phenylethyl]carbamoyl}phenyl 1-phenylmethanesulfonate	Investigative	23647286	C29H35N3O6S	553.7	C[C@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)OS(=O)(=O)CC3=CC=CC=C3)OCC(=O)NCCCCCN	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B1E3OQ	3-(4-Chlorobenzyl)-N-((1-ethylpyrrolidin-2-yl)methyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide	Investigative	4250961	C23H25ClN4O2S	457	CCN1CCCC1CNC(=O)C2=CC3=C(C=C2)C(=O)N(C(=S)N3)CC4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B1L0NT	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-1-(2,3-dihydro-1H-inden-2-ylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717654	C36H50F3N7O8	765.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CC2=CC=CC=C2C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B1LC7A	N-[3-(5-Amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl)phenyl]cyclohexanecarboxamide	Investigative	58118860	C18H25N3O2	315.4	CC1(COCC(=N1)N)C2=CC(=CC=C2)NC(=O)C3CCCCC3	IC50 ~ 130000 nM	Poor binder
T79031	Beta-secretase 1	B1YS7X	N-[[4-(1,3-Dihydroisoindol-2-ylmethyl)phenyl]methyl]-2-(4-phenylphenyl)acetamide	Investigative	71583022	C30H28N2O	432.6	C1C2=CC=CC=C2CN1CC3=CC=C(C=C3)CNC(=O)CC4=CC=C(C=C4)C5=CC=CC=C5	IC50 = 63300 nM	Poor binder
T79031	Beta-secretase 1	B21NZE	N-[[4-(Aminomethyl)phenyl]methyl]-2-(3-fluoro-4-phenylphenyl)propanamide	Investigative	71584646	C23H23FN2O	362.4	CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)NCC3=CC=C(C=C3)CN	IC50 = 77100 nM	Poor binder
T79031	Beta-secretase 1	B23ACN	N-(4-Chlorobenzyl)-3-[(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]-4-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)benzamide	Investigative	16004116	C33H31ClN4O6S	647.1	C1COC2=C(O1)C=CC(=C2)S(=O)(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC=C(C=C4)Cl)N5CC6CC(C5)C7=CC=CC(=O)N7C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B25IVJ	Rac-3-[(3-Butylureido)methyl]benzyl-5-isobutyl-5-phenethyl-2-iminohydantoin	Investigative	45484135	C28H39N5O2	477.6	CCCCNC(=O)NCC1=CC=C(C=C1)CN2C(=O)C(N=C2N)(CCC3=CC=CC=C3)CC(C)C	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B2CRB6	6'-Bromodispiro[1,3-oxazole-4,4'-chromene-3',3''-oxetan]-2-amine	Investigative	86724312	C13H13BrN2O3	325.16	C1C2(CO1)COC3=C(C24COC(=N4)N)C=C(C=C3)Br	IC50 = 59600 nM	Poor binder
T79031	Beta-secretase 1	B2HM4O	2-[4-(4-Chlorophenyl)-3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl-N-naphthalen-2-yl-N-phenylacetamide	Investigative	3131985	C37H26ClN3O2S	612.1	COC1=CC=C(C=C1)C2=NC(=C(C(=C2)C3=CC=C(C=C3)Cl)C#N)SCC(=O)N(C4=CC=CC=C4)C5=CC6=CC=CC=C6C=C5	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B2JV3B	3-(3-Amino-3-benzyl-4-hydroxybutyl)sulfonyl-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide	Investigative	46881572	C28H34FN3O6S2	591.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)S(=O)(=O)CCC(CC3=CC=CC=C3)(CO)N)N(C)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B2MYZ3	Neocyclomorusin	Investigative	5481973	C25H24O7	436.5	CC1(C=CC2=C(O1)C=C(C3=C2OC4=C(C3=O)CC(OC5=C4C=CC(=C5)O)C(C)(C)O)O)C	IC50 = 146100 nM	Poor binder
T79031	Beta-secretase 1	B2SV1X	(3R,4S,5S)-3-Amino-5-[(3-bromo-4-hydroxyphenyl)methyl]-1,1-dioxothian-4-ol	Investigative	54581139	C12H16BrNO4S	350.23	C1[C@H]([C@@H]([C@H](CS1(=O)=O)N)O)CC2=CC(=C(C=C2)O)Br	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B2T4FZ	N-(4-Iodophenyl)-6-methoxy-N'-(2-morpholin-4-ylethyl)-1,3,5-triazine-2,4-diamine	Investigative	4599004	C16H21IN6O2	456.28	COC1=NC(=NC(=N1)NC2=CC=C(C=C2)I)NCCN3CCOCC3	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B2WS5X	2-(5-((1H-Indol-3-yl)methyl)-4-benzyl-4H-1,2,4-triazol-3-ylthio)-1-(1H-indol-3-yl)ethanone	Investigative	1047096	C28H23N5OS	477.6	C1=CC=C(C=C1)CN2C(=NN=C2SCC(=O)C3=CNC4=CC=CC=C43)CC5=CNC6=CC=CC=C65	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B31XBK	6-Chloro-N2-(4-iodobenzyl)-N4-(2-morpholinoethyl)-1,3,5-triazine-2,4-diamine	Investigative	46906639	C16H20ClIN6O	474.7	C1COCCN1CCNC2=NC(=NC(=N2)Cl)NCC3=CC=C(C=C3)I	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B36MFN	4-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4-[2-(2-{3-hydroxy-6-methyl-4-[2-(3,4,5-trimethoxy-phenyl)-acetylamino]-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-butyric acid	Investigative	44296131	C41H59N5O13	829.9	C[C@H](C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CC2=CC(=C(C(=C2)OC)OC)OC)O	IC50 = 94000 nM	Poor binder
T79031	Beta-secretase 1	B39CSJ	6-Chloro-N-[(1S)-1-furo[2,3-d]pyrimidin-2-yl-2-phenylethyl]-3,3-dimethyl-2,4-dihydroisoquinolin-1-imine	Investigative	136219146	C25H23ClN4O	430.9	CC1(CC2=C(C=CC(=C2)Cl)C(=N[C@@H](CC3=CC=CC=C3)C4=NC=C5C=COC5=N4)N1)C	IC50 = 73700 nM	Poor binder
T79031	Beta-secretase 1	B39NGZ	4-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4-[2-(2-{4-[2-(2,4-difluoro-phenyl)-acetylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-propionylamino]-butyric acid	Investigative	44296370	C38H51F2N5O10	775.8	C[C@H](C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CC2=C(C=C(C=C2)F)F)O	IC50 = 140000 nM	Poor binder
T79031	Beta-secretase 1	B3AYF9	Chembl4204435	Investigative	129011640	C26H34O8	474.5	C[C@@]12CCC(=O)C([C@H]1C(=O)[C@H]([C@]3([C@H]2CC(=C)[C@@]4([C@@H]3C(=O)O[C@](C4=O)(C)C(=O)OC)C)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B3C2DR	Tert-butyl N-benzyl-N-[(2S)-2-hydroxy-2-[3-[[(2R)-2-phenyl-2-(phenylmethoxycarbonylamino)acetyl]amino]phenyl]ethyl]carbamate	Investigative	76335236	C36H39N3O6	609.7	CC(C)(C)OC(=O)N(CC1=CC=CC=C1)C[C@H](C2=CC(=CC=C2)NC(=O)[C@@H](C3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B3DJ4Y	N-{2-[(Heptafluoropropyl)sulfanyl]phenyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide	Investigative	3470183	C19H13F7N2O2S2	498.4	C1=CC=C2C(=C1)NC(=O)C(S2)CC(=O)NC3=CC=CC=C3SC(C(C(F)(F)F)(F)F)(F)F	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B3HMO9	2H-Phenanthro(1,2-c)pyran-2-carboxylic acid, 1,4,4a,4b,5,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-6,10b-dihydroxy-2,4b,7,7,10a,12a-hexamethyl-12-methylene-1,4,5,8-tetraoxo-, methyl ester, (2R,4aR,4bS,10aS,10bS,12aR)-	Investigative	109374149	C26H32O9	488.5	C[C@@]12CCC(=O)C(C1=C(C(=O)[C@]3([C@]2(CC(=C)[C@@]4([C@@H]3C(=O)O[C@](C4=O)(C)C(=O)OC)C)O)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B3IBT2	(E)-3-(3,4-Dihydroxyphenyl)-N-[[1-[[(3S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-yl]methyl]triazol-4-yl]methyl]prop-2-enamide	Investigative	134130755	C24H24N6O3	444.5	C1[C@H](NCC2=C1C3=CC=CC=C3N2)CN4C=C(N=N4)CNC(=O)/C=C/C5=CC(=C(C=C5)O)O	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B3LX6N	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717586	C36H58F3N7O8	773.9	CC(C)C[C@@H]([C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B3M5XP	2-Benzyl-3-hydroxy-2-(methylamino)propyl 3-((R)-1-(4-fluorophenyl)ethylcarbamoyl)-5-(N-methylmethylsulfonamido)benzoate	Investigative	11387554	C29H34FN3O6S	571.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)C(=O)OCC(CC3=CC=CC=C3)(CO)NC	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B3O0BD	Chembl4215650	Investigative	139590114	C26H34O8	474.5	C[C@@]12CCC(=O)C([C@H]1C(=O)[C@H]([C@]3([C@H]2CC(=C)[C@@]4([C@H]3C(=O)O[C@](C4=O)(C)C(=O)OC)C)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B3QYS6	3-[4-[(1R,2S)-2-(2-Amino-1-methyl-6-oxopyrimidin-4-yl)cyclopropyl]phenyl]benzamide	Investigative	71453445	C21H20N4O2	360.4	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=C(C=C3)C4=CC(=CC=C4)C(=O)N	IC50 = 59900 nM	Poor binder
T79031	Beta-secretase 1	B3TE0A	Tert-butyl N-[(2S)-1-[[(2S)-4-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-3-methyl-1-oxobutan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1-methylsulfanyl-3-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	76316917	C37H63N5O7S	722	C[C@H](C[C@@H]([C@H](CC(C)C)NCC(=O)[C@@H](CSC)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC1=CC=CC=C1	Ki = 50118.72 nM	Poor binder
T79031	Beta-secretase 1	B3US9N	(4S)-4-Amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2R,3S)-1-[[(1S)-1-carboxybutyl]amino]-2-hydroxy-5-methyl-1-oxohexan-3-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	122185859	C30H49N5O9S	655.8	CCC[C@@H](C(=O)O)NC(=O)[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CS1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)N)O	IC50 = 56000 nM	Poor binder
T79031	Beta-secretase 1	B3W1RU	N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-phenyl-2-(thiophene-2-sulfonamido)acetamide	Investigative	22427309	C19H14ClF3N2O3S2	474.9	C1=CC=C(C=C1)C(C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)NS(=O)(=O)C3=CC=CS3	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B40ZPG	US8975415, RP1a	Investigative	86724291	C14H15BrN2O3	339.18	C1CC2(COC3=C(C24COC(=N4)N)C=C(C=C3)Br)OC1	IC50 = 73300 nM	Poor binder
T79031	Beta-secretase 1	B41KWH	CID 58197581	Investigative	58197581	C26H28N4O2	428.5	CN1C(=O)CC2(C3=C(CC24CCC(CC4)OC)C=CC(=C3)C5=CC=CC(=C5)C#N)N=C1N	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B43QIW	2-Amino-6-[(1S,2R)-2-[4-(furan-2-yl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71462339	C18H17N3O2	307.3	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=C(C=C3)C4=CC=CO4	IC50 = 59000 nM	Poor binder
T79031	Beta-secretase 1	B43SRW	(4As,6S,8aR)-6-cyclopropyl-8a-(2,4-difluorophenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	90253452	C16H18F2N2OS	324.4	C1CC1[C@@H]2C[C@@H]3CSC(=N[C@@]3(CO2)C4=C(C=C(C=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B47GMY	2-Amino-6-[(1S,2R)-2-[3-(6-methoxypyrazin-2-yl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71614888	C19H19N5O2	349.4	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=CC(=C3)C4=CN=CC(=N4)OC	IC50 = 84900 nM	Poor binder
T79031	Beta-secretase 1	B4E8XR	(4S)-4-Amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-4-[[(1S)-1-carboxybutyl]amino]-1-cyclohexyl-3-hydroxy-4-oxobutan-2-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	122185860	C33H53N5O9S	695.9	CCC[C@@H](C(=O)O)NC(=O)[C@@H]([C@H](CC1CCCCC1)NC(=O)[C@H](CC2=CC=CS2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)N)O	IC50 = 64000 nM	Poor binder
T79031	Beta-secretase 1	B4G9XS	(4S,5R)-4-(2,4-Difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	118732789	C13H16F2N2OS	286.34	C[C@]1([C@@H](CSC(=N1)N)COC)C2=C(C=C(C=C2)F)F	IC50 = 88000 nM	Poor binder
T79031	Beta-secretase 1	B4H1RF	CID 46927332	Investigative	46927332	C19H24BrN3O2	406.3	CN1C(=O)CC2(C3=C(CC24CCC(CC4)OC)C=CC(=C3)Br)N=C1N	IC50 = 200000 nM	Poor binder
T79031	Beta-secretase 1	B4K2AY	2-Amino-3-methyl-6-[(1S,2R)-2-[3-(3-methylphenyl)phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71614689	C21H21N3O	331.4	CC1=CC(=CC=C1)C2=CC(=CC=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 74900 nM	Poor binder
T79031	Beta-secretase 1	B4LT3Q	(3S,4S)-4-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[(2-phenylmethoxyacetyl)amino]pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717663	C36H52F3N7O8	767.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)COCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B4MP1C	N''-(3-Ethoxy-4-hydroxy-5-iodobenzylidene)-2-(p-tolyloxy)acetohydrazide	Investigative	136016388	C18H19IN2O4	454.3	CCOC1=C(C(=CC(=C1)/C=N\\NC(=O)COC2=CC=C(C=C2)C)I)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B4USV1	US8975415, RP12a	Investigative	90056179	C16H17BrN2O3	365.22	C1CC1C2C3(COC3)C4(COC(=N4)N)C5=C(O2)C=CC(=C5)Br	IC50 = 81300 nM	Poor binder
T79031	Beta-secretase 1	B4YFE6	CID 90246729	Investigative	90246729	C18H18N4O3	338.4	C1CC2(COC3=C(C24COC(=N4)N)C=C(C=C3)C5=CN=CN=C5)OC1	IC50 = 64100 nM	Poor binder
T79031	Beta-secretase 1	B51YJC	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]carbamate	Investigative	118717573	C35H50N4O6	622.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B57JTL	(4Ar,8aS)-8a-(2-methoxyphenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	71268733	C14H18N2O2S	278.37	COC1=CC=CC=C1[C@]23COCC[C@H]2CSC(=N3)N	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B57UJA	(4S)-4-[2,4-Difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137646316	C15H18F5N3S	367.4	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CNCCC(F)(F)F)F)F	IC50 = 54700 nM	Poor binder
T79031	Beta-secretase 1	B5FH0R	Mormin	Investigative	54587663	C25H24O8	452.5	C/C(=C/CC1=C(OC2=C(C1=O)C(=CC3=C2C=CC(O3)(C)CO)O)C4=C(C=C(C=C4)O)O)/CO	IC50 = 103500 nM	Poor binder
T79031	Beta-secretase 1	B5N1PA	8-Benzyl-4-cyclohexylimino-1-(3,3-dimethylbutyl)-1,3,8-triazaspiro[4.5]decan-2-one	Investigative	135960747	C26H40N4O	424.6	CC(C)(C)CCN1C(=O)NC(=NC2CCCCC2)C13CCN(CC3)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B5PVI0	Xestosaprol K	Investigative	46849025	C20H18O4	322.4	C[C@@]12CC[C@@H]([C@H]3C1=C(C(=O)C4=C2C=C5C(=C4)C=CC=C5O)OC3)O	IC50 = 93000 nM	Poor binder
T79031	Beta-secretase 1	B5Q3ER	3-[[(2-Hexyl-4-oxoquinazolin-3-yl)amino]-hydroxymethyl]-4-hydroxy-1-azatricyclo[7.3.1.05,13]trideca-3,5,7,9(13)-tetraen-2-one	Investigative	54729809	C27H30N4O4	474.6	CCCCCCC1=NC2=CC=CC=C2C(=O)N1NC(C3=C(C4=CC=CC5=C4N(C3=O)CCC5)O)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B5RS7U	3-Acetamido-N-(3-chloro-5-fluorobenzyl)-4-(4-chlorophenylthio)benzamide	Investigative	46907116	C22H17Cl2FN2O2S	463.4	CC(=O)NC1=C(C=CC(=C1)C(=O)NCC2=CC(=CC(=C2)Cl)F)SC3=CC=C(C=C3)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B5UPY6	Ethyl 2-(9,10-dioxo-9,10-dihydroanthracene-2-sulfonamido)-3-(4-hydroxyphenyl)propanoate	Investigative	3959062	C25H21NO7S	479.5	CCOC(=O)C(CC1=CC=C(C=C1)O)NS(=O)(=O)C2=CC3=C(C=C2)C(=O)C4=CC=CC=C4C3=O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B5WRS4	2-Amino-3-methyl-6-phenethyl-3H-pyrimidin-4-one	Investigative	16722358	C13H15N3O	229.28	CN1C(=O)C=C(N=C1N)CCC2=CC=CC=C2	IC50 = 150000 nM	Poor binder
T79031	Beta-secretase 1	B5ZUF2	6-Chloro-3,3-dimethyl-N-[1-(1,3,4-oxadiazol-2-yl)-2-phenylethyl]-2,4-dihydroisoquinolin-1-imine	Investigative	136219154	C21H21ClN4O	380.9	CC1(CC2=C(C=CC(=C2)Cl)C(=NC(CC3=CC=CC=C3)C4=NN=CO4)N1)C	IC50 = 184900 nM	Poor binder
T79031	Beta-secretase 1	B61KVO	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]acetamide	Investigative	71584650	C24H20F6N2O	466.4	C1=CC(=CC=C1CC(=O)NCC2=CC=C(C=C2)CN)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F	IC50 = 63900 nM	Poor binder
T79031	Beta-secretase 1	B61YWD	N-[3-[4-[(1R,2S)-2-(2-Amino-1-methyl-6-oxopyrimidin-4-yl)cyclopropyl]phenyl]phenyl]acetamide	Investigative	71462336	C22H22N4O2	374.4	CC(=O)NC1=CC=CC(=C1)C2=CC=C(C=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 70000 nM	Poor binder
T79031	Beta-secretase 1	B62TBQ	N-(4-(Aminosulfonyl)phenyl)-2-((5,6-diphenyl-1,2,4-triazin-3-YL)thio)acetamide	Investigative	6405777	C23H19N5O3S2	477.6	C1=CC=C(C=C1)C2=C(N=NC(=N2)SCC(=O)NC3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B65IQE	6-[2-(1H-Indol-6-yl)ethyl]pyridin-2-amine	Investigative	11586735	C15H15N3	237.3	C1=CC(=NC(=C1)N)CCC2=CC3=C(C=C2)C=CN3	IC50 = 94000 nM	Poor binder
T79031	Beta-secretase 1	B67NLA	3-[(2-Amino-2-benzyl-3-methoxypropoxy)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide	Investigative	46881612	C29H36FN3O5S	557.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)COCC(CC3=CC=CC=C3)(COC)N)N(C)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B68JNU	Xestosaprol F	Investigative	46848865	C22H22O5	366.4	C[C@@]12CC[C@@H]([C@H]3C1=C(C(=O)C4=C2C=C5C=CC=C(C5=C4)OCCO)OC3)O	IC50 = 135000 nM	Poor binder
T79031	Beta-secretase 1	B6A8GX	4-(2-Amino-5-chlorobenzimidazol-1-yl)-N-[(3-fluorophenyl)methyl]-N-methylbutanamide	Investigative	49864603	C19H20ClFN4O	374.8	CN(CC1=CC(=CC=C1)F)C(=O)CCCN2C3=C(C=C(C=C3)Cl)N=C2N	IC50 = 194000 nM	Poor binder
T79031	Beta-secretase 1	B6ALG4	N-[[4-(Aminomethyl)phenyl]methyl]-2-(2-hydroxy-4-phenylphenyl)acetamide	Investigative	71584525	C22H22N2O2	346.4	C1=CC=C(C=C1)C2=CC(=C(C=C2)CC(=O)NCC3=CC=C(C=C3)CN)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6D7SK	Benzyl (3s,5'r)-2-Oxo-1,2-Dihydrospiro[indole-3,3'-Pyrrolidine]-5'-Carboxylate	Investigative	56940706	C19H18N2O3	322.4	C1[C@@H](NC[C@@]12C3=CC=CC=C3NC2=O)C(=O)OCC4=CC=CC=C4	IC50 = 85700 nM	Poor binder
T79031	Beta-secretase 1	B6H5XD	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717658	C35H49ClF3N7O8	788.3	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=C(C=C1)Cl)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6I9SR	Chembl4209304	Investigative	139590110	C26H34O7	458.5	C[C@H]1C(=O)[C@]2([C@]3(CC(=O)[C@H]4[C@]([C@@H]3CC(=C)[C@]2(C(=O)O1)C)(CCC(=O)C4(C)C)C)C)C(=O)OC	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B6JW1X	2-Amino-3-methyl-6-[(1S,2R)-2-[4-(3-propan-2-yloxyphenyl)phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71462501	C23H25N3O2	375.5	CC(C)OC1=CC=CC(=C1)C2=CC=C(C=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 54000 nM	Poor binder
T79031	Beta-secretase 1	B6L9FN	6-Methyl-2-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]chromene-3-carboxamide	Investigative	118711813	C30H33N3O3	483.6	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NCCCCCCNC3=C4CCCCC4=NC5=CC=CC=C53	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6MO2T	(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]pentanediamide	Investigative	118717559	C24H45N9O7	571.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N[C@@H](CCC(=O)N)C(=O)N)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6O3MX	N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-3-(4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)propanamide	Investigative	6619193	C21H24N4O4S2	460.6	C1CCC2=C(C1)C3=C(S2)N=C(NC3=O)CCC(=O)NCCC4=CC=C(C=C4)S(=O)(=O)N	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B6QL2R	8-Benzyl-4-(cyclohexylamino)-1,3,8-triazaspiro[4.5]dec-3-en-2-one	Investigative	135875881	C20H28N4O	340.5	C1CCC(CC1)N=C2C3(CCN(CC3)CC4=CC=CC=C4)NC(=O)N2	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6R5EH	Benzyl N-[(2S)-6-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamate;hydrochloride	Investigative	118717568	C31H52ClN5O6	626.2	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCCN)NC(=O)OCC2=CC=CC=C2.Cl	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B6UPC8	2-Amino-6-methyl-6-phenyl-5,6-dihydro-3h-pyrimidin-4-one	Investigative	23730921	C11H13N3O	203.24	CC1(CC(=O)NC(=N1)N)C2=CC=CC=C2	IC50 = 140000 nM	Poor binder
T79031	Beta-secretase 1	B78PIM	Xestosaprol J	Investigative	46849024	C21H20O4	336.4	C[C@@]12CC[C@@H]([C@H]3C1=C(C(=O)C4=C2C=C5C(=C4)C=CC=C5OC)OC3)O	IC50 = 90000 nM	Poor binder
T79031	Beta-secretase 1	B7BDK6	2-Amino-6-[2-(1H-indol-6-yl)ethyl]-3-methylpyrimidin-4(3H)-one	Investigative	11565240	C15H16N4O	268.31	CN1C(=O)C=C(N=C1N)CCC2=CC3=C(C=C2)C=CN3	IC50 = 77000 nM	Poor binder
T79031	Beta-secretase 1	B7GBP9	2-({6-[(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)amino]-1,3-benzothiazol-2-yl}sulfanyl)-N-(4-ethoxyphenyl)acetamide	Investigative	4338097	C28H32N8O4S2	608.7	CCOC1=CC=C(C=C1)NC(=O)CSC2=NC3=C(S2)C=C(C=C3)NC4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B7M1XJ	CID 90056473	Investigative	90056473	C24H24N4O3	416.5	CC1=CN2C=CC(=CC2=N1)C3=CC4=C(C=C3)OC5(CCC5)C6(C47COC(=N7)N)COC6	IC50 = 135000 nM	Poor binder
T79031	Beta-secretase 1	B83GKF	S-Benzo[d]thiazol-2-yl 2-(2-(2-(4-methoxybenzamido)benzamido)-4-(methylthio)butanoyl)hydrazinecarbothioate	Investigative	46906686	C28H27N5O5S3	609.7	COC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2C(=O)NC(CCSC)C(=O)NNC(=O)SC3=NC4=CC=CC=C4S3	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	B89QYX	Benzyl N-[(2S)-5-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;hydrochloride	Investigative	118717566	C30H50ClN5O6	612.2	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN)NC(=O)OCC2=CC=CC=C2.Cl	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B8AC6Y	Triethyl-[[4-[[[2-(4-phenylphenyl)acetyl]amino]methyl]phenyl]methyl]azanium	Investigative	71583025	C28H35N2O+	415.6	CC[N+](CC)(CC)CC1=CC=C(C=C1)CNC(=O)CC2=CC=C(C=C2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B8FM4U	N-(4-Chlorophenyl)-2-(2,5-dimethoxyphenylimino)-5-(hydroxymethyl)-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamide	Investigative	46369107	C25H22ClN3O5	479.9	CC1=NC=C(C2=C1OC(=NC3=C(C=CC(=C3)OC)OC)C(=C2)C(=O)NC4=CC=C(C=C4)Cl)CO	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B8HT0B	2-Amino-6-[(1S,2R)-2-[4-(6-methoxypyridin-2-yl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71462340	C20H20N4O2	348.4	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=C(C=C3)C4=NC(=CC=C4)OC	IC50 = 53300 nM	Poor binder
T79031	Beta-secretase 1	B92MIH	(2S)-2-[[(2S)-2-[[4-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoic acid	Investigative	44322212	C28H51N5O8S	617.8	C[C@@H](C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)CC(C(CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)C)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B9AS4E	CID 90056449	Investigative	90056449	C19H19N3O3	337.4	CC1=NC=CC(=C1)C2=CC3=C(C=C2)OCC4(C35COC(=N5)N)COC4	IC50 = 55400 nM	Poor binder
T79031	Beta-secretase 1	B9BEZ6	N-(1-Adamantyl)-2-{[3-cyano-4-(4-fluorophenyl)-6-phenyl-2-pyridinyl]sulfanyl}acetamide	Investigative	4538151	C30H28FN3OS	497.6	C1C2CC3CC1CC(C2)(C3)NC(=O)CSC4=C(C(=CC(=N4)C5=CC=CC=C5)C6=CC=C(C=C6)F)C#N	IC50 = 118000 nM	Poor binder
T79031	Beta-secretase 1	B9D4PF	5-Substituted isophthalamide, 3	Investigative	23647407	C21H27N3O6S	449.5	CNC(=O)C1=CC(=CC(=C1)N(C)S(=O)(=O)C)C(=O)NC(CC2=CC(=CC=C2)OC)CO	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	B9GHI3	(4S)-4-[2,4-Difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137654633	C18H20F2N4S	362.4	CC1=CN=C(C=C1)NCC2=CC(=C(C=C2F)F)[C@@]3(CCSC(=N3)N)C	IC50 = 73500 nM	Poor binder
T79031	Beta-secretase 1	B9JYM6	2-Amino-6-[(1S,2R)-2-[3-[2-(3-methoxyphenyl)ethyl]phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71615091	C23H25N3O2	375.5	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=CC(=C3)CCC4=CC(=CC=C4)OC	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B9LWC7	2-{[4-Oxo-3-(prop-2-en-1-yl)-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-(4-sulfamoylphenyl)acetamide	Investigative	1594254	C21H22N4O4S3	490.6	C=CCN1C(=O)C2=C(N=C1SCC(=O)NC3=CC=C(C=C3)S(=O)(=O)N)SC4=C2CCCC4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B9M3DH	2-[[6-[[4,6-Di(piperidin-1-yl)-1,3,5-triazin-2-yl]amino]-1,3-benzothiazol-2-yl]sulfanyl]-N-phenylacetamide	Investigative	52949415	C28H32N8OS2	560.7	C1CCN(CC1)C2=NC(=NC(=N2)NC3=CC4=C(C=C3)N=C(S4)SCC(=O)NC5=CC=CC=C5)N6CCCCC6	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	B9QO7H	3-[(4-Anilino-6-piperidin-1-yl-1,3,5-triazin-2-yl)amino]-2-(4-chlorophenyl)-1,3-thiazolidin-4-one	Investigative	5162066	C23H24ClN7OS	482	C1CCN(CC1)C2=NC(=NC(=N2)NN3C(SCC3=O)C4=CC=C(C=C4)Cl)NC5=CC=CC=C5	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	B9RSQ6	trans-2-Phenylvinylboronic acid MIDA ester	Investigative	71310633	C13H14BNO4	259.07	B1(OC(=O)CN(CC(=O)O1)C)/C=C/C2=CC=CC=C2	IC50 = 136150 nM	Poor binder
T79031	Beta-secretase 1	BA37RV	[(3S,4R)-4-(2-Bromophenyl)pyrrolidin-3-yl]-(2-phenylpiperidin-1-yl)methanone	Investigative	57394453	C22H25BrN2O	413.3	C1CCN(C(C1)C2=CC=CC=C2)C(=O)[C@@H]3CNC[C@H]3C4=CC=CC=C4Br	IC50 = 57000 nM	Poor binder
T79031	Beta-secretase 1	BA92BH	Chembl4204943	Investigative	139590118	C27H38O8	490.6	C[C@@]12CCC(=O)C([C@H]1C(=O)C[C@]3([C@H]2CC(=C)[C@@]([C@@H]3C(=O)OC)(C)C(=O)[C@@](C)(C(=O)OC)O)C)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BAK6Q8	[1-(1-{1-[1-Hydroxy-2-(1-hydroxycarbamoyl-2-methyl-propylcarbamoyl)-ethyl]-3-methyl-butylcarbamoyl}-3-methylsulfanyl-propylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester	Investigative	44296484	C28H53N5O8S	619.8	CC(C)CC([C@H](CC(=O)N[C@H](C(C)C)C(=O)NO)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C	IC50 = 94000 nM	Poor binder
T79031	Beta-secretase 1	BAW47B	2,3,4,5-Tetra(3,4,5-trihydroxyphenylcarbonyloxy)-6-(3,4,5-trihydroxyphenylcarbonyloxymethyl)-(2R,3S,4R,5S,6S)-tetrahydro-2H-pyran	Investigative	44350821	C41H32O26	940.7	C1=C(C=C(C(=C1O)O)O)C(=O)OC[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O	IC50 ~ 160000 nM	Poor binder
T79031	Beta-secretase 1	BAX1M6	2-Amino-6-(3,4-dichlorophenyl)-6-methyl-5,6-dihydro-3H-pyrimidin-4-one	Investigative	11565289	C11H11Cl2N3O	272.13	CC1(CC(=O)NC(=N1)N)C2=CC(=C(C=C2)Cl)Cl	IC50 = 79000 nM	Poor binder
T79031	Beta-secretase 1	BB1T4O	(4R,4As,6S,8aR)-6-cyclopropyl-8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	90253570	C17H19F3N2OS	356.4	C1CC1[C@@H]2C[C@@H]3[C@@H](SC(=N[C@@]3(CO2)C4=C(C=C(C=C4)F)F)N)CF	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BB2NL5	Xestosaprol L	Investigative	46849026	C20H18O3	306.4	C[C@@]12CC[C@@H]([C@H]3C1=C(C(=O)C4=CC5=CC=CC=C5C=C24)OC3)O	IC50 = 98000 nM	Poor binder
T79031	Beta-secretase 1	BBTS84	FC1(F)COC(N)=NC11C2(CC2)COC2=CC=C(Br)C=C21	Investigative	90026141	C14H13BrF2N2O2	359.17	C1CC12COC3=C(C24C(COC(=N4)N)(F)F)C=C(C=C3)Br	IC50 = 55800 nM	Poor binder
T79031	Beta-secretase 1	BBUS19	(1S,2S,6R,10R,12R,15R,16S)-12-Chloro-6-ethyl-15-hydroxy-6-methyl-17-oxapentacyclo[14.2.1.01,13.02,10.05,9]nonadeca-5(9),13-dien-18-one	Investigative	134149181	C21H27ClO3	362.9	CC[C@@]1(CCC2=C1CC[C@H]3[C@H]2C[C@H](C4=C[C@H]([C@@H]5C[C@]34C(=O)O5)O)Cl)C	IC50 = 82000 nM	Poor binder
T79031	Beta-secretase 1	BC1TO5	Chembl4216625	Investigative	139590119	C27H36O9	504.6	C[C@@]12CCC(=O)C(C1=C(C(=O)[C@]3([C@H]2CC(=C)[C@@]([C@@H]3C(=O)OC)(C)C(=O)[C@@](C)(C(=O)OC)O)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BC48OG	N-(2-(2-Methylpiperidin-1-yl)ethyl)-6-(morpholinosulfonyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide	Investigative	46907117	C22H30N4O5S	462.6	CC1CCCCN1CCNC(=O)C2=CC(=O)NC3=C2C=C(C=C3)S(=O)(=O)N4CCOCC4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BC63ME	Xanthotoxol geranyl ether	Investigative	5317564	C21H22O4	338.4	CC(=CCC/C(=C/COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)/C)C	Ki = 61600 nM	Poor binder
T79031	Beta-secretase 1	BC68JH	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717582	C35H56F3N7O8	759.9	CC(C)C[C@@H]([C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BCR81J	N-[2-(4-Chlorophenyl)ethyl]-4-{[(2-thioxo-1,2-dihydroquinazolin-4-yl)amino]methyl}cyclohexanecarboxamide	Investigative	4112670	C24H27ClN4OS	455	C1CC(CCC1CNC2=NC(=S)NC3=CC=CC=C32)C(=O)NCCC4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BCS8W1	4-((6,7-Dimethoxy-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(4-methylbenzyl)benzamide	Investigative	15988250	C26H25N3O5	459.5	CC1=CC=C(C=C1)CNC(=O)C2=CC=C(C=C2)CN3C(=O)C4=CC(=C(C=C4NC3=O)OC)OC	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BD6QS8	(R)-Methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)pentanamido)-3-tert-butoxypropanoate	Investigative	49864728	C20H29ClN4O4	424.9	CC[C@@H](CC(=O)N[C@H](COC(C)(C)C)C(=O)OC)N1C2=C(C=C(C=C2)Cl)N=C1N	IC50 = 75000 nM	Poor binder
T79031	Beta-secretase 1	BD8IB4	Tetrahydro-2h-Pyran-4-Yl (3s,5'r)-2-Oxo-1,2-Dihydrospiro[indole-3,3'-Pyrrolidine]-5'-Carboxylate	Investigative	56940705	C17H20N2O4	316.35	C1COCCC1OC(=O)[C@H]2C[C@@]3(CN2)C4=CC=CC=C4NC3=O	IC50 = 114000 nM	Poor binder
T79031	Beta-secretase 1	BD91YV	Phenyl-substituted sulfonamides, 6c	Investigative	44236885	C32H37N3O4S2	591.8	C1=CC=C(C=C1)CN(CCCNCCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4	Ki = 150000 nM	Poor binder
T79031	Beta-secretase 1	BD9PI4	N-[2-[(4Ar,6S)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-1-methyl-5-(2-methylpropyl)pyrazole-3-carboxamide	Investigative	118435609	C20H28N6O2S2	448.6	C[C@H]1C[C@H]2CSC(=NC2(CO1)C3=NC(=CS3)NC(=O)C4=NN(C(=C4)CC(C)C)C)N	IC50 = 51000 nM	Poor binder
T79031	Beta-secretase 1	BDK13X	2-Amino-6-[2-[3-(3-methoxyphenyl)phenyl]ethyl]-3-methylpyrimidin-4-one	Investigative	11652923	C20H21N3O2	335.4	CN1C(=O)C=C(N=C1N)CCC2=CC(=CC=C2)C3=CC(=CC=C3)OC	IC50 = 91000 nM	Poor binder
T79031	Beta-secretase 1	BDQR73	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-cyclohexyl-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717564	C27H48F3N7O7	639.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BE4W7K	Chembl4213164	Investigative	145964643	C27H38O9	506.6	C[C@@]12CCC(=O)C([C@H]1C(=O)[C@H]([C@]3([C@H]2CC(=C)[C@@]([C@@H]3C(=O)OC)(C)C(=O)[C@@](C)(C(=O)OC)O)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BE9V1A	(4S)-4-[5-[(Dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	Investigative	137662127	C14H19F2N3S	299.38	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)CN(C)C)F)F	IC50 = 50900 nM	Poor binder
T79031	Beta-secretase 1	BEF6D1	(5R,7S)-1-(3-Fluorophenyl)-8-[(3-methoxyphenyl)methyl]-7-methyl-2lambda6-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide	Investigative	66930522	C21H26FN3O3S	419.5	C[C@H]1C[C@]2(CCN1CC3=CC(=CC=C3)OC)CNS(=O)(=O)N2C4=CC(=CC=C4)F	IC50 = 99300 nM	Poor binder
T79031	Beta-secretase 1	BEUQ29	4-Bromo-N-[(4-bromophenyl)sulfonyl]-N-[1-(3,4-dichlorobenzyl)-1H-pyrazol-4-yl]benzenesulfonamide	Investigative	4415300	C22H15Br2Cl2N3O4S2	680.2	C1=CC(=CC=C1S(=O)(=O)N(C2=CN(N=C2)CC3=CC(=C(C=C3)Cl)Cl)S(=O)(=O)C4=CC=C(C=C4)Br)Br	IC50 = 90000 nM	Poor binder
T79031	Beta-secretase 1	BEY4X8	2-Amino-3-methyl-6-[(1S,2R)-2-[4-(4-methylphenyl)phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71456952	C21H21N3O	331.4	CC1=CC=C(C=C1)C2=CC=C(C=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 119000 nM	Poor binder
T79031	Beta-secretase 1	BFC0B7	3,3''-(Piperazine-1,4-diylbis(methylene))dibiphenyl-4-ol	Investigative	5031416	C30H30N2O2	450.6	C1CN(CCN1CC2=C(C=CC(=C2)C3=CC=CC=C3)O)CC4=C(C=CC(=C4)C5=CC=CC=C5)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BFN8B9	3-Benzylsulfonyl-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	49863029	C33H41N3O5S	591.8	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC(=CC=C3)S(=O)(=O)CC4=CC=CC=C4)O	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	BFP04L	4-({2-[3-Hydroxy-4-(2-hydroxy-2-naphthalen-1-yl-acetylamino)-6-methyl-heptanoylamino]-3-methyl-butyrylamino}-methyl)-benzoic acid	Investigative	11966417	C33H41N3O7	591.7	CC(C)C[C@@H]([C@H](CC(=O)N[C@@H](C(C)C)C(=O)NCC1=CC=C(C=C1)C(=O)O)O)NC(=O)C(C2=CC=CC3=CC=CC=C32)O	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	BFW59B	6-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-N-(2-(dimethylamino)ethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide	Investigative	46907194	C23H26N4O4S	454.5	CN(C)CCNC(=O)C1=CNC2=C(C1=O)C=C(C=C2)S(=O)(=O)N3CCC4=CC=CC=C4C3	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BG48QX	2-Ethyl-2-(3-pyrimidin-5-ylphenyl)-1,3-benzoxazin-4-amine	Investigative	71682752	C20H18N4O	330.4	CCC1(N=C(C2=CC=CC=C2O1)N)C3=CC=CC(=C3)C4=CN=CN=C4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BG49AW	4-({(S)-2-[(2S,4S)-4-((3S,4S)-4-Tert-Butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoylamino)-5-cyclohexyl-3-hydroxy-pentanoylamino]-3-methyl-butyrylamino}-methyl)-benzoic acid	Investigative	44343498	C40H58N4O9	738.9	CC(C)[C@@H](C(=O)NCC1=CC=C(C=C1)C(=O)O)NC(=O)C[C@@H]([C@H](CC2CCCCC2)NC(=O)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BG5N1U	Chembl4203972	Investigative	139590115	C27H36O8	488.6	CCOC(=O)[C@@]1(C(=O)[C@]2([C@H](C(=O)O1)[C@@]3([C@@H](CC2=C)[C@@]4(CCC(=O)C([C@H]4C(=O)[C@H]3O)(C)C)C)C)C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BG5S6W	Phenyl-substituted sulfonamides, 6f	Investigative	44236887	C32H39N5O4S2	621.8	C1=CC=C(C=C1)CN(CCCNCCCN(CC2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N)S(=O)(=O)C4=CC=C(C=C4)N	Ki = 64000 nM	Poor binder
T79031	Beta-secretase 1	BG7KQ4	6-Chloro-3,3-dimethyl-N-(2-phenyl-1-pyrimidin-2-ylethyl)-2,4-dihydroisoquinolin-1-imine	Investigative	136219152	C23H23ClN4	390.9	CC1(CC2=C(C=CC(=C2)Cl)C(=NC(CC3=CC=CC=C3)C4=NC=CC=N4)N1)C	IC50 = 137100 nM	Poor binder
T79031	Beta-secretase 1	BG8SP1	3-N-[(1S,2S)-1-[(2S,5S)-4-Benzyl-5-methyl-3-oxopiperazin-2-yl]-1-hydroxy-3-phenylpropan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide	Investigative	68256677	C39H45N5O6S	711.9	C[C@H]1CN[C@H](C(=O)N1CC2=CC=CC=C2)[C@H]([C@H](CC3=CC=CC=C3)NC(=O)C4=CC(=CC(=C4)C(=O)N[C@H](C)C5=CC=CC=C5)N(C)S(=O)(=O)C)O	Ki = 52900 nM	Poor binder
T79031	Beta-secretase 1	BGAS34	N-[(2S,3R)-4-[[1-(4-Tert-butyl-1,3-oxazol-2-yl)cyclohexyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide	Investigative	52942779	C25H35F2N3O3	463.6	CC(=O)N[C@@H](CC1=CC(=CC(=C1)F)F)[C@@H](CNC2(CCCCC2)C3=NC(=CO3)C(C)(C)C)O	IC50 = 137800 nM	Poor binder
T79031	Beta-secretase 1	BGBT37	Chembl4211731	Investigative	139590111	C26H30O9	486.5	C[C@@]12CCC(=O)C(C1=C(C(=O)[C@]3([C@@]24[C@@H](O4)C(=C)[C@@]5([C@@H]3C(=O)O[C@](C5=O)(C)C(=O)OC)C)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BGJP37	(4S)-5-[[(1S)-1-Carboxy-2-phenylethyl]amino]-4-[[(2S)-2-[[(2S)-2-[[4-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid	Investigative	44321943	C34H53N7O11	735.8	C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)CC(C(CC(C)C)NC(=O)[C@H](CC(=O)N)N)O	IC50 ~ 150000 nM	Poor binder
T79031	Beta-secretase 1	BGU63D	2-Amino-3-methyl-6-[2-(3-pyridin-3-ylphenyl)ethyl]pyrimidin-4-one	Investigative	11587584	C18H18N4O	306.4	CN1C(=O)C=C(N=C1N)CCC2=CC(=CC=C2)C3=CN=CC=C3	IC50 = 190000 nM	Poor binder
T79031	Beta-secretase 1	BGYH84	6-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)-4-oxo-N-phenethyl-1,4-dihydroquinoline-3-carboxamide	Investigative	23769141	C27H25N3O4S	487.6	C1CN(CC2=CC=CC=C21)S(=O)(=O)C3=CC4=C(C=C3)NC=C(C4=O)C(=O)NCCC5=CC=CC=C5	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BH07ZN	6,7-Furano-5-prenyloxy hydrocoumaric acid	Investigative	46229681	C16H18O5	290.31	CC(=CCOC1=C(C(=CC2=C1C=CO2)O)CCC(=O)O)C	IC50 = 185600 nM	Poor binder
T79031	Beta-secretase 1	BH3T2E	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717570	C33H52F3N7O8	731.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BH50DS	N-Benzyl-N'-{4-[chloro(difluoro)methoxy]phenyl}-6-(piperidin-1-yl)-1,3,5-triazine-2,4-diamine	Investigative	1826494	C22H23ClF2N6O	460.9	C1CCN(CC1)C2=NC(=NC(=N2)NC3=CC=C(C=C3)OC(F)(F)Cl)NCC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BH5V2P	6-(N-Methyl-N-m-tolylsulfamoyl)-N-(2-morpholinoethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide	Investigative	4652689	C24H28N4O5S	484.6	CC1=CC(=CC=C1)N(C)S(=O)(=O)C2=CC3=C(C=C2)NC=C(C3=O)C(=O)NCCN4CCOCC4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BH8N6F	1,4-Di(carbazol-9-yl)butan-2-ol	Investigative	70692714	C28H24N2O	404.5	C1=CC=C2C(=C1)C3=CC=CC=C3N2CCC(CN4C5=CC=CC=C5C6=CC=CC=C64)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BHA61F	2-Amino-3-methyl-6-[(1S,2R)-2-[3-[2-(2-methylphenyl)ethyl]phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71615088	C23H25N3O	359.5	CC1=CC=CC=C1CCC2=CC(=CC=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 120000 nM	Poor binder
T79031	Beta-secretase 1	BHE63I	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-(4-hydroxyphenyl)phenyl]acetamide	Investigative	71582925	C22H22N2O2	346.4	C1=CC(=CC=C1CC(=O)NCC2=CC=C(C=C2)CN)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BHF9Q4	Chembl4218091	Investigative	129011631	C24H32O6	416.5	C[C@H]1C(=O)[C@]2([C@H](C(=O)O1)[C@@]3([C@@H](CC2=C)[C@@]4(CCC(=O)C([C@H]4C(=O)[C@H]3O)(C)C)C)C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BHSN25	4-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4-{2-[2-(3-hydroxy-6-methyl-4-phenylacetylamino-heptanoylamino)-3-methyl-butyrylamino]-propionylamino}-butyric acid	Investigative	44296371	C38H53N5O10	739.9	C[C@H](C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CC2=CC=CC=C2)O	IC50 = 130000 nM	Poor binder
T79031	Beta-secretase 1	BHUW49	US8865911, 47 Isomer 4	Investigative	57386155	C17H20BrN3O2	378.3	CC1=NC2(CC(OC3=C2C=C(C=C3)Br)C4CCCOC4)N=C1N	IC50 = 65300 nM	Poor binder
T79031	Beta-secretase 1	BI05LX	(S)-2-((S)-3-(2-Amino-5-chloro-1H-benzo[d]imidazol-1-yl)pentanamido)-3-tert-butoxypropanoic acid	Investigative	49864729	C19H27ClN4O4	410.9	CC[C@@H](CC(=O)N[C@@H](COC(C)(C)C)C(=O)O)N1C2=C(C=C(C=C2)Cl)N=C1N	IC50 = 87000 nM	Poor binder
T79031	Beta-secretase 1	BI7Y9Z	4-(2-Amino-5-chlorobenzimidazol-1-yl)-N-(cyclohexylmethyl)-N-methylbutanamide	Investigative	49864604	C19H27ClN4O	362.9	CN(CC1CCCCC1)C(=O)CCCN2C3=C(C=C(C=C3)Cl)N=C2N	IC50 = 59000 nM	Poor binder
T79031	Beta-secretase 1	BIA4O0	5-{1-[2-(1-{1-[3-Carboxy-1-(1-carboxy-2-phenyl-ethylcarbamoyl)-propylcarbamoyl]-ethylcarbamoyl}-2-methyl-propylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-pentanoic acid methyl ester	Investigative	44295917	C37H57N5O12	763.9	C[C@H](C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CCCCC(=O)OC)O	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	BIAU70	1,8-Dibenzyl-4-(cyclohexylamino)-1,3,8-triazaspiro[4.5]dec-3-en-2-one	Investigative	135875883	C27H34N4O	430.6	C1CCC(CC1)N=C2C3(CCN(CC3)CC4=CC=CC=C4)N(C(=O)N2)CC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BIF23P	(3R,4S,5S)-3-(3-Bromo-4-hydroxybenzyl)-5-(3-isopropylbenzylamino)tetrahydro-2H-pyran-4-ol	Investigative	54581101	C22H28BrNO3	434.4	CC(C)C1=CC=CC(=C1)CN[C@H]2COC[C@H]([C@@H]2O)CC3=CC(=C(C=C3)O)Br	IC50 = 55000 nM	Poor binder
T79031	Beta-secretase 1	BISV45	1-N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-methanesulfonamidobenzene-1,3-dicarboxamide	Investigative	11169204	C30H35FN4O5S	582.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)NS(=O)(=O)C)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNC4CC4)O	IC50 = 63000 nM	Poor binder
T79031	Beta-secretase 1	BIY8H7	Chembl4205875	Investigative	145975161	C26H36O6	444.6	C[C@@]12CCC(=O)C([C@H]1CC[C@]3([C@H]2CC(=C)[C@@]4([C@]3(C(=O)[C@@](C4=O)(C)O)C(=O)OC)C)C)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BJ0H6Q	(S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcarbamoyl-heptyl)-2-(3-methyl-butyrylamino)-succinamic acid	Investigative	44370558	C28H45N3O6	519.7	CCC[C@H](C[C@@H]([C@H](CC1=CC=CC=C1)NC(=O)C[C@@H](C(=O)O)NC(=O)CC(C)C)O)C(=O)NCC(C)C	Ki = 69500 nM	Poor binder
T79031	Beta-secretase 1	BJ0Q1T	9-(3-Naphthalen-2-ylsulfanyl-2-piperazin-1-ylpropyl)carbazole	Investigative	70690564	C29H29N3S	451.6	C1CN(CCN1)C(CN2C3=CC=CC=C3C4=CC=CC=C42)CSC5=CC6=CC=CC=C6C=C5	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BJ2YI8	Cruzain-IN-1	Investigative	44143088	C14H10F2N6	300.27	CCN1C=NC2=C(N=C(N=C21)C#N)NC3=CC(=CC(=C3)F)F	IC50 = 63095.73 nM	Poor binder
T79031	Beta-secretase 1	BJ3FN2	Chembl4168528	Investigative	136078846	C18H16ClN3O	325.8	C1=CC=C(C(=C1)C=NCCNC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 ~ 160000 nM	Poor binder
T79031	Beta-secretase 1	BJ5QT9	Chembl4218151	Investigative	139590116	C27H40O9	508.6	C[C@@]12CC[C@H](C([C@H]1C(=O)[C@H]([C@]3([C@H]2CC(=C)[C@@]([C@@H]3C(=O)OC)(C)C(=O)[C@@](C)(C(=O)OC)O)C)O)(C)C)O	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BJ67NI	1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-one	Investigative	70696799	C25H19NOS	381.5	C1=CC=C2C=C(C=CC2=C1)SCC(=O)CN3C4=CC=CC=C4C5=CC=CC=C53	IC50 ~ 80000 nM	Poor binder
T79031	Beta-secretase 1	BJ7BZ1	N-[3-(5-Amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl)phenyl]pyridine-3-carboxamide	Investigative	50914252	C17H18N4O2	310.35	CC1(COCC(=N1)N)C2=CC(=CC=C2)NC(=O)C3=CN=CC=C3	IC50 = 60000 nM	Poor binder
T79031	Beta-secretase 1	BJ80LH	3-(3-Amino-3-benzyl-4-hydroxybutoxy)-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide	Investigative	46881526	C28H34FN3O5S	543.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)OCCC(CC3=CC=CC=C3)(CO)N)N(C)S(=O)(=O)C	IC50 = 70500 nM	Poor binder
T79031	Beta-secretase 1	BJ89FA	N-{3-[(4-Butylphenyl)amino]quinoxalin-2-yl}-4-chlorobenzenesulfonamide	Investigative	5135855	C24H23ClN4O2S	467	CCCCC1=CC=C(C=C1)NC2=NC3=CC=CC=C3N=C2NS(=O)(=O)C4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BJ90HP	N-(4-Chlorophenethyl)-4-((6-morpholino-4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)benzamide	Investigative	4670102	C28H27ClN4O3S	535.1	C1COCCN1C2=CC3=C(C=C2)NC(=S)N(C3=O)CC4=CC=C(C=C4)C(=O)NCCC5=CC=C(C=C5)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BJB0R1	(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717666	C36H54F3N7O8S	801.9	CC(C)C[C@@H]([C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)CC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BJI2L1	2-(2-(2-(8-Methyl-2-oxo-4-propyl-2H-chromen-7-yloxy)acetamido)acetamido)acetic acid	Investigative	1798772	C19H22N2O7	390.4	CCCC1=CC(=O)OC2=C1C=CC(=C2C)OCC(=O)NCC(=O)NCC(=O)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BJK70L	(4As,8aR)-8a-(2,4-difluorophenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	71277796	C13H14F2N2OS	284.33	C1COC[C@@]2([C@H]1CSC(=N2)N)C3=C(C=C(C=C3)F)F	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BJLQ26	(1-{1-[1-(1-Hydroxy-2-{2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-3-methylsulfanyl-propylcarbamoyl}-2-methyl-propyl)-carbamic acid tert-butyl ester	Investigative	44296653	C34H58N6O7S	694.9	CC(C)CC([C@H](CC(=O)N[C@H](C(C)C)C(=O)NCC1=CC=NC=C1)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BJTM14	(1-{1-[1-(2-{1-[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-2-methyl-propylcarbamoyl}-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-3-methylsulfanyl-propylcarbamoyl}-2-methyl-propyl)-carbamic acid tert-butyl ester	Investigative	44296399	C36H59N5O9S	737.9	CC(C)CC([C@H](CC(=O)N[C@H](C(C)C)C(=O)NCC1=CC2=C(C=C1)OCO2)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BJZ09P	2-(6-Bromo-2-(morpholinomethyl)-4-phenylquinazolin-3(4H)-yl)acetohydrazide	Investigative	2870407	C21H24BrN5O2	458.4	C1COCCN1CC2=NC3=C(C=C(C=C3)Br)C(N2CC(=O)NN)C4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BKQ3X4	4-Acetamido-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide	Investigative	44454542	C28H38N4O4	494.6	C[C@@H](C(=O)NC1CCCCC1)NC[C@H]([C@H](CC2=CC=CC=C2)NC(=O)C3=CC=C(C=C3)NC(=O)C)O	IC50 = 62000 nM	Poor binder
T79031	Beta-secretase 1	BKX5E4	(2R)-N-[[4-(Aminomethyl)phenyl]methyl]-2-(3-fluoro-4-phenylphenyl)propanamide	Investigative	71584647	C23H23FN2O	362.4	C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)NCC3=CC=C(C=C3)CN	IC50 = 85700 nM	Poor binder
T79031	Beta-secretase 1	BL2SB7	4-(2-{2-[4-(2-Biphenyl-4-yl-acetylamino)-3-hydroxy-6-methyl-heptanoylamino]-3-methyl-butyrylamino}-propionylamino)-4-(1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid	Investigative	44296317	C44H57N5O10	815.9	C[C@H](C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@@H](C(C)C)NC(=O)C[C@@H](C(CC(C)C)NC(=O)CC2=CC=C(C=C2)C3=CC=CC=C3)O	IC50 = 56000 nM	Poor binder
T79031	Beta-secretase 1	BL3M4E	2-Methyl-5-propan-2-yl-2-(3-pyridin-3-ylphenyl)imidazol-4-amine	Investigative	71459165	C18H20N4	292.4	CC(C)C1=NC(N=C1N)(C)C2=CC=CC(=C2)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BLFI71	2-(4-Benzylpiperazin-1-yl)-N''-(2-hydroxy-3,5-diiodobenzylidene)acetohydrazide	Investigative	136016426	C20H22I2N4O2	604.2	C1CN(CCN1CC2=CC=CC=C2)CC(=O)N/N=C\\C3=C(C(=CC(=C3)I)I)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BLJD56	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-(2,3,4,5,6-pentafluorophenyl)phenyl]acetamide	Investigative	71582923	C22H17F5N2O	420.4	C1=CC(=CC=C1CC(=O)NCC2=CC=C(C=C2)CN)C3=C(C(=C(C(=C3F)F)F)F)F	IC50 = 101000 nM	Poor binder
T79031	Beta-secretase 1	BLOK04	Chembl262454	Investigative	73345437	C78H126N20O30	1824	CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)N	IC50 = 60000 nM	Poor binder
T79031	Beta-secretase 1	BLS3A7	2-Amino-6-[(1S,2R)-2-[3-(3-fluorophenyl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71614886	C20H18FN3O	335.4	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=CC(=C3)C4=CC(=CC=C4)F	IC50 = 72400 nM	Poor binder
T79031	Beta-secretase 1	BLS81G	Latifolin	Investigative	340211	C17H18O4	286.32	COC1=CC(=C(C=C1[C@H](C=C)C2=CC=CC=C2O)O)OC	IC50 = 180000 nM	Poor binder
T79031	Beta-secretase 1	BLUP17	Isoliquiritigenin	Investigative	638278	C15H12O4	256.25	C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O	IC50 = 51500 nM	Poor binder
T79031	Beta-secretase 1	BM0VT7	5-{2-[3-Hydroxy-4-(2-hydroxy-2-naphthalen-1-yl-acetylamino)-6-methyl-heptanoylamino]-3-methyl-butyrylamino}-cyclohexane-1,3-dicarboxylic acid dimethyl ester	Investigative	10919408	C35H49N3O9	655.8	CC(C)C[C@@H]([C@H](CC(=O)N[C@@H](C(C)C)C(=O)NC1C[C@@H](C[C@@H](C1)C(=O)OC)C(=O)OC)O)NC(=O)C(C2=CC=CC3=CC=CC=C32)O	IC50 = 140000 nM	Poor binder
T79031	Beta-secretase 1	BM2O9Q	(S)-3-(2-Amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-benzylpentanamide	Investigative	49864606	C19H21ClN4O	356.8	CC[C@@H](CC(=O)NCC1=CC=CC=C1)N2C3=C(C=C(C=C3)Cl)N=C2N	IC50 = 72000 nM	Poor binder
T79031	Beta-secretase 1	BM6G8Y	4-({(S)-2-[(2S,4S)-4-((3S,4S)-4-Amino-3-hydroxy-5-phenyl-pentanoylamino)-5-cyclohexyl-3-hydroxy-pentanoylamino]-3-methyl-butyrylamino}-methyl)-benzoic acid	Investigative	44343583	C35H50N4O7	638.8	CC(C)[C@@H](C(=O)NCC1=CC=C(C=C1)C(=O)O)NC(=O)C[C@@H]([C@H](CC2CCCCC2)NC(=O)C[C@@H]([C@H](CC3=CC=CC=C3)N)O)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BM7J5R	3-(4-Chlorobenzyl)-N-(2-(4-ethylpiperazin-1-yl)ethyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide	Investigative	6616205	C24H28ClN5O2S	486	CCN1CCN(CC1)CCNC(=O)C2=CC3=C(C=C2)C(=O)N(C(=S)N3)CC4=CC=C(C=C4)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BMAV21	N-Benzyl-2-(6-(4,6-dimorpholino-1,3,5-triazin-2-ylamino)benzo[d]thiazol-2-ylthio)acetamide	Investigative	6616618	C27H30N8O3S2	578.7	C1COCCN1C2=NC(=NC(=N2)NC3=CC4=C(C=C3)N=C(S4)SCC(=O)NCC5=CC=CC=C5)N6CCOCC6	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	BMRE96	3-{[(5-Aminopentyl)carbamoyl]methoxy}-5-{[(1S)-1-phenylethyl]carbamoyl}phenyl 1-phenylmethanesulfonate	Investigative	23647287	C29H35N3O6S	553.7	C[C@@H](C1=CC=CC=C1)NC(=O)C2=CC(=CC(=C2)OS(=O)(=O)CC3=CC=CC=C3)OCC(=O)NCCCCCN	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BMYE37	(3R,4S,5S)-3-(Benzylamino)-5-[(3-bromo-4-hydroxyphenyl)methyl]-1,1-dioxothian-4-ol	Investigative	54585056	C19H22BrNO4S	440.4	C1[C@H]([C@@H]([C@H](CS1(=O)=O)NCC2=CC=CC=C2)O)CC3=CC(=C(C=C3)O)Br	IC50 = 66000 nM	Poor binder
T79031	Beta-secretase 1	BMZ19J	4-(2-Amino-5-chloro-1H-benzo[d]imidazol-1-yl)-N-(cyclohexylmethyl)butanamide	Investigative	49864533	C18H25ClN4O	348.9	C1CCC(CC1)CNC(=O)CCCN2C3=C(C=C(C=C3)Cl)N=C2N	IC50 = 83000 nM	Poor binder
T79031	Beta-secretase 1	BN42RQ	Chembl327385	Investigative	73354525	C35H59N7O14S	833.9	C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CC([C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)C)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BND2X6	Xestosaprol I	Investigative	46849023	C20H18O3	306.4	C[C@@]12CC[C@H]([C@H]3C1=C(C(=O)C4=CC5=CC=CC=C5C=C24)OC3)O	IC50 = 163000 nM	Poor binder
T79031	Beta-secretase 1	BNE06J	2-Amino-3-Methyl-6-[(1s,2r)-2-Phenylcyclopropyl]pyrimidin-4(3h)-One	Investigative	66545742	C14H15N3O	241.29	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=CC=C3	IC50 = 157000 nM	Poor binder
T79031	Beta-secretase 1	BNIO16	N-[5-(2,3-Dichlorobenzyl)-1,3-thiazol-2-yl]-4-({[4-phenyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)benzamide	Investigative	5181282	C31H22Cl2N6OS2	629.6	C1=CC=C(C=C1)N2C(=NN=C2SCC3=CC=C(C=C3)C(=O)NC4=NC=C(S4)CC5=C(C(=CC=C5)Cl)Cl)C6=CC=NC=C6	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BO62XJ	N-Benzyl-6-bromo-3-(4-ethylphenyl)-4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazoline-4-carboxamide	Investigative	4068751	C24H22BrN3O3	480.4	CCC1=CC=C(C=C1)N2C(=O)NC3=C(C2(C(=O)NCC4=CC=CC=C4)O)C=C(C=C3)Br	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BO70XY	Cyclomorusin	Investigative	5481969	C25H22O6	418.4	CC(=CC1C2=C(C3=C(O1)C=C(C=C3)O)OC4=C(C2=O)C(=CC5=C4C=CC(O5)(C)C)O)C	IC50 = 101200 nM	Poor binder
T79031	Beta-secretase 1	BOC4R5	N-(2-Acetylphenyl)-4-(5-isoquinolin-2-ium-2-ylpentoxy)benzamide;bromide	Investigative	71456803	C29H29BrN2O3	533.5	CC(=O)C1=CC=CC=C1NC(=O)C2=CC=C(C=C2)OCCCCC[N+]3=CC4=CC=CC=C4C=C3.[Br-]	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BOD04P	6-(4-Methylpiperidin-1-ylsulfonyl)-2-oxo-N-(3-(pyrrolidin-1-yl)propyl)-1,2-dihydroquinoline-4-carboxamide	Investigative	16003623	C23H32N4O4S	460.6	CC1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C=C3C(=O)NCCCN4CCCC4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BOG51L	9-Hydroxy-4-(3,7-dimethyl-2,6-octadienyloxy)-psoralen	Investigative	6440422	C22H24O5	368.4	CC(=CCC/C(=C/COC1=C2C=COC2=C(C3=C1C=CC(=O)O3)OC)/C)C	Ki = 102700 nM	Poor binder
T79031	Beta-secretase 1	BOP76U	N-(2-(2-Methylpiperidin-1-yl)ethyl)-2-oxo-6-(piperidin-1-ylsulfonyl)-1,2-dihydroquinoline-4-carboxamide	Investigative	15999741	C23H32N4O4S	460.6	CC1CCCCN1CCNC(=O)C2=CC(=O)NC3=C2C=C(C=C3)S(=O)(=O)N4CCCCC4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BOU4B5	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-(4-amino-4-oxobutyl)-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717562	C25H45F3N8O8	642.7	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCCC(=O)N)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BOZ20V	2-(4-Phenylphenyl)-N-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]acetamide	Investigative	71583021	C26H28N2O	384.5	C1CCN(C1)CC2=CC=C(C=C2)CNC(=O)CC3=CC=C(C=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BP07DS	4-Cyclohexylimino-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-2-one;dihydrochloride	Investigative	135998870	C19H27Cl2FN4O	417.3	C1CCC(CC1)N=C2C3(CCNCC3)N(C(=O)N2)C4=CC(=CC=C4)F.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BP2NK5	Isophthalamide Derivative 5f	Investigative	16659107	C36H55N5O8S	717.9	C[C@H](C[C@@H]([C@H](CC(C)C)NC(=O)C1=CC(=CC(=C1)N(C)S(=O)(=O)C)C(=O)N[C@H](CO)C2=CC=CC=C2)O)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C	IC50 = 190000 nM	Poor binder
T79031	Beta-secretase 1	BP52UH	4-Butoxy-3-chlorobenzyl imidothiocarbamate	Investigative	1609819	C12H17ClN2OS	272.79	CCCCOC1=C(C=C(C=C1)CSC(=N)N)Cl	IC50 = 200000 nM	Poor binder
T79031	Beta-secretase 1	BP5V3F	CID 53375047	Investigative	53375047	C23H30F3N3O2	437.5	COC1CCC2(CC1)CC3=C(C24C5CCCC(N5C(=N4)N)C(F)(F)F)C=C(C=C3)OC	IC50 = 50000 nM	Poor binder
T79031	Beta-secretase 1	BP6LM9	Morusinol	Investigative	5481968	C25H26O7	438.5	CC1(C=CC2=C(O1)C=C(C3=C2OC(=C(C3=O)CCC(C)(C)O)C4=C(C=C(C=C4)O)O)O)C	IC50 = 135900 nM	Poor binder
T79031	Beta-secretase 1	BP7Y9C	N-[[4-(Diethylaminomethyl)phenyl]methyl]-2-(4-phenylphenyl)acetamide	Investigative	71583023	C26H30N2O	386.5	CCN(CC)CC1=CC=C(C=C1)CNC(=O)CC2=CC=C(C=C2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BPM7J4	(4S)-4-Amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2R,3S)-1-[[(1S)-1-carboxybutyl]amino]-2-hydroxy-5-methylhexan-3-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Investigative	91809482	C30H51N5O8S	641.8	CCC[C@@H](C(=O)O)NC[C@H]([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CS1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)N)O	IC50 = 72000 nM	Poor binder
T79031	Beta-secretase 1	BPZT14	(S)-Methyl 2-((S)-3-(2-amino-5-chloro-1H-benzo[d]imidazol-1-yl)pentanamido)-3-tert-butoxypropanoate	Investigative	49864727	C20H29ClN4O4	424.9	CC[C@@H](CC(=O)N[C@@H](COC(C)(C)C)C(=O)OC)N1C2=C(C=C(C=C2)Cl)N=C1N	IC50 = 168000 nM	Poor binder
T79031	Beta-secretase 1	BR0ZN5	N-(2-Benzoyl-4-chlorophenyl)-4-[(6-bromo-4-phenylquinazolin-2-yl)amino]benzamide	Investigative	4131129	C34H22BrClN4O2	633.9	C1=CC=C(C=C1)C2=NC(=NC3=C2C=C(C=C3)Br)NC4=CC=C(C=C4)C(=O)NC5=C(C=C(C=C5)Cl)C(=O)C6=CC=CC=C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BR2K3Q	Xestosaprol G	Investigative	46849021	C20H18O4	322.4	C[C@@]12CC[C@@H]([C@H]3C1=C(C(=O)C4=C2C=C5C=CC=C(C5=C4)O)OC3)O	IC50 = 155000 nM	Poor binder
T79031	Beta-secretase 1	BR3KO2	Norartocarpetin	Investigative	5481970	C15H10O6	286.24	C1=CC(=C(C=C1O)O)C2=CC(=O)C3=C(C=C(C=C3O2)O)O	IC50 = 60600 nM	Poor binder
T79031	Beta-secretase 1	BRBI85	Chembl4170012	Investigative	145953952	C16H15N3O2	281.31	C1=CC2=C(N=C1)N(C=C2)CCN=CC3=C(C=C(C=C3)O)O	IC50 = 106700 nM	Poor binder
T79031	Beta-secretase 1	BRS6Y2	3-[((S)-2-{(3S,4S)-4-[(R)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-methyl]-benzoic acid	Investigative	44357330	C32H51N5O8	633.8	C[C@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N[C@@H](C(C)C)C(=O)NCC1=CC(=CC=C1)C(=O)O)O)NC(=O)[C@H](CC(C)C)NC(=O)C	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	BS4NC5	Xestosaprol M	Investigative	46849027	C20H16O2	288.3	C[C@@]12CCCC3=COC(=C31)C(=O)C4=CC5=CC=CC=C5C=C24	IC50 = 104000 nM	Poor binder
T79031	Beta-secretase 1	BS7J2O	6-Bromo-3-(4-ethylphenyl)-4-hydroxy-N-(2-methyl-3-(4-methylpiperidin-1-yl)propyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-4-carboxamide	Investigative	4140894	C27H35BrN4O3	543.5	CCC1=CC=C(C=C1)N2C(=O)NC3=C(C2(C(=O)NCC(C)CN4CCC(CC4)C)O)C=C(C=C3)Br	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BS9UX3	2-Amino-6-[(1R,2S)-2-[3-(3-methoxyphenyl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71458819	C21H21N3O2	347.4	CN1C(=O)C=C(N=C1N)[C@@H]2C[C@@H]2C3=CC=CC(=C3)C4=CC(=CC=C4)OC	IC50 = 103000 nM	Poor binder
T79031	Beta-secretase 1	BSFP51	2-Amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one	Investigative	135424789	C14H14N4O	254.29	C1=CC(=CC2=C1C=CN2)CCC3=CC(=O)NC(=N3)N	IC50 = 86000 nM	Poor binder
T79031	Beta-secretase 1	BSH19G	3-(3-Bromobenzyl)-N-((1-ethylpyrrolidin-2-yl)methyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide	Investigative	4088061	C23H25BrN4O2S	501.4	CCN1CCCC1CNC(=O)C2=CC3=C(C=C2)C(=O)N(C(=S)N3)CC4=CC(=CC=C4)Br	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BSVF48	Hydroxyamphetamine	Investigative	3651	C9H13NO	151.21	CC(CC1=CC=C(C=C1)O)N	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BT05UL	N-Benzyl-4-oxo-6-(N-(2-oxoazepan-3-yl)sulfamoyl)-1,4-dihydroquinoline-3-carboxamide	Investigative	46907048	C23H24N4O5S	468.5	C1CCNC(=O)C(C1)NS(=O)(=O)C2=CC3=C(C=C2)NC=C(C3=O)C(=O)NCC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BT23ZP	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethyl-methylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717660	C36H51ClF3N7O8	802.3	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N(C)CCC1=CC=C(C=C1)Cl)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BT3P7Y	2-Amino-6-[(1S,2R)-2-[4-(2-methoxypyridin-4-yl)phenyl]cyclopropyl]-3-methylpyrimidin-4-one	Investigative	71451786	C20H20N4O2	348.4	CN1C(=O)C=C(N=C1N)[C@H]2C[C@H]2C3=CC=C(C=C3)C4=CC(=NC=C4)OC	IC50 = 116000 nM	Poor binder
T79031	Beta-secretase 1	BT60MY	2-[(6-{[4,6-Di(morpholin-4-yl)-1,3,5-triazin-2-yl]amino}-1,3-benzothiazol-2-yl)sulfanyl]-N-(2,4,6-trimethylphenyl)acetamide	Investigative	4655667	C29H34N8O3S2	606.8	CC1=CC(=C(C(=C1)C)NC(=O)CSC2=NC3=C(S2)C=C(C=C3)NC4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BTG1F3	(2S)-2-[[4-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoic acid	Investigative	44322158	C25H46N4O7S	546.7	CC(C)CC(C(CC(=O)N[C@@H](C(C)C)C(=O)O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BTQ82S	2-Amino-3-methyl-6-[(1S,2R)-2-[4-(4-methylthiophen-2-yl)phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71451612	C19H19N3OS	337.4	CC1=CSC(=C1)C2=CC=C(C=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 50700 nM	Poor binder
T79031	Beta-secretase 1	BTU6N4	CID 54578013	Investigative	54578013	C24H22ClFN4O2	452.9	C[C@]1(C[C@H](OCC(=N1)N)C2=CC=CC=C2)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)Cl)F	IC50 = 142000 nM	Poor binder
T79031	Beta-secretase 1	BU4SO2	3-[(3-Amino-3-benzyl-4-hydroxybutyl)amino]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide	Investigative	46881570	C28H35FN4O4S	542.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)N(C)S(=O)(=O)C)NCCC(CC3=CC=CC=C3)(CO)N	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BU69WR	Chembl4213706	Investigative	145965821	C26H32O8	472.5	C[C@@]12CCC(=O)C(C1=C(C(=O)[C@]3([C@H]2CC(=C)[C@@]4([C@@H]3C(=O)O[C@](C4=O)(C)C(=O)OC)C)C)O)(C)C	IC50 ~ 50000 nM	Poor binder
T79031	Beta-secretase 1	BU92GS	(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3S)-piperidin-3-yl]methyl]imidazol-4-one	Investigative	118719665	C18H32N4O	320.5	CN1C(=O)[C@@](N=C1N)(CCC2CCCCC2)C[C@@H]3CCCNC3	Ki = 66000 nM	Poor binder
T79031	Beta-secretase 1	BUR20N	(3S)-3-(2-Amino-5-chlorobenzimidazol-1-yl)-N-(3,3-dimethylbutyl)pentanamide	Investigative	49864695	C18H27ClN4O	350.9	CC[C@@H](CC(=O)NCCC(C)(C)C)N1C2=C(C=C(C=C2)Cl)N=C1N	IC50 = 95000 nM	Poor binder
T79031	Beta-secretase 1	BUVJ40	(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzenesulfonamido)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717664	C33H48F3N7O8S	759.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BV3T9J	(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid	Investigative	118717665	C34H50F3N7O8S	773.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)CC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BV5KH3	3-(3-Chloro-4-methoxyphenyl)-N-(2-(6-methylpyridin-2-ylamino)-2-oxoethyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide	Investigative	15995071	C24H20ClN5O4	477.9	CC1=NC(=CC=C1)NC(=O)CNC(=O)C2=NN(C(=O)C3=CC=CC=C32)C4=CC(=C(C=C4)OC)Cl	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BV6L7A	N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-methoxypiperidine-1-carboxamide	Investigative	86732158	C19H24F4N4O3	432.4	C[C@]1(C[C@H](OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)N3CCC(CC3)OC)F	IC50 = 55800 nM	Poor binder
T79031	Beta-secretase 1	BV9HK1	N-[3-(5-Amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl)phenyl]-4,4-difluorocyclohexane-1-carboxamide	Investigative	58118867	C18H23F2N3O2	351.4	CC1(COCC(=N1)N)C2=CC(=CC=C2)NC(=O)C3CCC(CC3)(F)F	IC50 ~ 130000 nM	Poor binder
T79031	Beta-secretase 1	BVN30I	(S)-4-Amino-4-((S)-1-{(S)-2-carbamoyl-1-[(S)-1-((S)-2-carbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-ethylcarbamoyl}-2-methyl-propylcarbamoyl)-butyric acid	Investigative	44357172	C22H40N6O8	516.6	CC(C)C[C@@H]([C@H](CC(=O)N)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)N	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	BVX83P	N-(2-Chlorobenzyl)-3-[(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]-4-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)benzamide	Investigative	16004117	C33H31ClN4O6S	647.1	C1COC2=C(O1)C=CC(=C2)S(=O)(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC=CC=C4Cl)N5CC6CC(C5)C7=CC=CC(=O)N7C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BW1R4P	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(2-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717652	C35H50F3N7O8	753.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BW4QK3	N-[[4-(Aminomethyl)phenyl]methyl]-2-[4-[3-(trifluoromethyl)phenyl]phenyl]acetamide	Investigative	71582924	C23H21F3N2O	398.4	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(C=C2)CC(=O)NCC3=CC=C(C=C3)CN	IC50 = 58900 nM	Poor binder
T79031	Beta-secretase 1	BWC67B	3-[(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]-N-(4-methylbenzyl)-4-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)benzamide	Investigative	15993676	C34H34N4O6S	626.7	CC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)N3CC4CC(C3)C5=CC=CC(=O)N5C4)NS(=O)(=O)C6=CC7=C(C=C6)OCCO7	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BWD1X0	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(benzylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717650	C34H48F3N7O8	739.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NCC1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BWD4O0	Byakangelicol	Investigative	3055167	C17H16O6	316.3	CC1([C@H](O1)COC2=C3C(=C(C4=C2OC(=O)C=C4)OC)C=CO3)C	IC50 = 104900 nM	Poor binder
T79031	Beta-secretase 1	BWE64A	Rac-3-[(3-Butyl-ureidomethyl)benzyl]-5-isobutyl-5-methyl-2-iminohydantoin	Investigative	45484174	C21H33N5O2	387.5	CCCCNC(=O)NCC1=CC=C(C=C1)CN2C(=O)C(N=C2N)(C)CC(C)C	IC50 = 78000 nM	Poor binder
T79031	Beta-secretase 1	BWVD87	4-(Cyclohexylamino)-1-(3-fluorophenyl)-8-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one	Investigative	135875884	C25H28F2N4O	438.5	C1CCC(CC1)N=C2C3(CCN(CC3)C4=CC=C(C=C4)F)N(C(=O)N2)C5=CC(=CC=C5)F	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BX0F2Z	(S)-4-((S)-2-{(S)-2-[(3S,4S)-4-((S)-2-Amino-3-carbamoyl-propionylamino)-3-hydroxy-6-methyl-heptanoylamino]-3-methyl-butyrylamino}-propionylamino)-4-((S)-1-carboxy-2-phenyl-ethylcarbamoyl)-butyric acid	Investigative	11125485	C34H53N7O11	735.8	C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)N)O	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	BX2OF9	6-Bromo-5'-methylspiro[2,3-dihydro-1H-naphthalene-4,2'-imidazole]-4'-amine	Investigative	57386415	C13H14BrN3	292.17	CC1=NC2(CCCC3=C2C=C(C=C3)Br)N=C1N	IC50 = 75600 nM	Poor binder
T79031	Beta-secretase 1	BX65LE	Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(1-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717656	C35H50F3N7O8	753.8	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC(C)C1=CC=CC=C1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BX87SB	(3R,4S,5S)-3-Amino-5-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-1-oxothian-4-ol	Investigative	73356861	C16H22F4N2O4S	414.4	COC[C@H](C(F)(F)F)OC1=C(C(=CC(=C1)C[C@@H]2CS(=O)C[C@@H]([C@H]2O)N)F)N	IC50 = 150000 nM	Poor binder
T79031	Beta-secretase 1	BX89VJ	2-Amino-3-methyl-6-[(1S,2R)-2-[4-(5-methylthiophen-2-yl)phenyl]cyclopropyl]pyrimidin-4-one	Investigative	71455157	C19H19N3OS	337.4	CC1=CC=C(S1)C2=CC=C(C=C2)[C@@H]3C[C@@H]3C4=CC(=O)N(C(=N4)N)C	IC50 = 165000 nM	Poor binder
T79031	Beta-secretase 1	BXG2P5	Benzyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxo-4-[[1-oxo-1-[(2-oxo-2-phenylmethoxyethyl)amino]-3-phenylmethoxypropan-2-yl]amino]butanoate	Investigative	3108347	C35H41N3O9	647.7	CC(C)(C)OC(=O)NC(CC(=O)OCC1=CC=CC=C1)C(=O)NC(COCC2=CC=CC=C2)C(=O)NCC(=O)OCC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BXL0Q9	N-{2-Fluoro-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide	Investigative	25138206	C17H15FN4O2S	358.4	CS(=O)(=O)NC1=C(C=CC(=C1)NC2=NC=NC(=C2)C3=CC=CC=C3)F	IC50 = 110000 nM	Poor binder
T79031	Beta-secretase 1	BXVD39	N-[[4-(Aminomethyl)phenyl]methyl]-2-(3-hydroxy-4-phenylphenyl)acetamide	Investigative	71584645	C22H22N2O2	346.4	C1=CC=C(C=C1)C2=C(C=C(C=C2)CC(=O)NCC3=CC=C(C=C3)CN)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BY1A6I	{(S)-1-[(S)-1-((2S,4S)-1-Benzyl-2-hydroxy-4-{(R)-2-methyl-1-[(pyridin-4-ylmethyl)-carbamoyl]-propylcarbamoyl}-pentylcarbamoyl)-ethylcarbamoyl]-3-dimethylamino-propyl}-carbamic acid tert-butyl ester	Investigative	44318059	C38H59N7O7	725.9	C[C@H](C[C@@H]([C@H](CC1=CC=CC=C1)NC(=O)[C@H](C)NC(=O)[C@H](CCN(C)C)NC(=O)OC(C)(C)C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC2=CC=NC=C2	IC50 = 89000 nM	Poor binder
T79031	Beta-secretase 1	BY21SQ	Tert-butyl N-[(2S)-1-[[(3S)-1-amino-5-[[(4S,5S,7R)-8-[[(2S)-1-(benzylamino)-1-oxopropan-2-yl]amino]-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]amino]-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	76327856	C35H58N6O8	690.9	C[C@H](C[C@@H]([C@H](CC(C)C)NCC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C)O)C(=O)N[C@@H](C)C(=O)NCC1=CC=CC=C1	Ki = 61376.2 nM	Poor binder
T79031	Beta-secretase 1	BY2M3T	Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717648	C39H56F3N7O8	807.9	CC(C)C[C@@H]([C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BY4C2U	(6As,12aR)-11,12a-dihydroxy-4,9-dimethoxy-10-methyl-6,6a-dihydrochromeno[3,4-b]chromen-12-one	Investigative	90644231	C19H18O7	358.3	CC1=C(C=C2C(=C1O)C(=O)[C@@]3([C@@H](O2)COC4=C3C=CC=C4OC)O)OC	IC50 = 62210 nM	Poor binder
T79031	Beta-secretase 1	BY5C0E	N-Benzyl-3-[(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]-4-(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)benzamide	Investigative	16000372	C33H32N4O6S	612.7	C1COC2=C(O1)C=CC(=C2)S(=O)(=O)NC3=C(C=CC(=C3)C(=O)NCC4=CC=CC=C4)N5CC6CC(C5)C7=CC=CC(=O)N7C6	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BY6MX5	(4Ar,8aS)-8a-[2-(trifluoromethoxy)phenyl]-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine	Investigative	59281187	C14H15F3N2O2S	332.34	C1COC[C@]2([C@@H]1CSC(=N2)N)C3=CC=CC=C3OC(F)(F)F	IC50 = 87900 nM	Poor binder
T79031	Beta-secretase 1	BY6R9J	3-[((R)-2-{(3S,4S)-4-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-methyl]-benzoic acid	Investigative	44357237	C34H55N5O8S	693.9	CC(C)C[C@@H]([C@H](CC(=O)N[C@H](C(C)C)C(=O)NCC1=CC(=CC=C1)C(=O)O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)C	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	BY7SW2	Xestosaprol H	Investigative	46849022	C22H22O5	366.4	C[C@@]12CC[C@H]([C@H]3C1=C(C(=O)C4=C2C=C5C=CC=C(C5=C4)OCCO)OC3)O	IC50 = 82000 nM	Poor binder
T79031	Beta-secretase 1	BY98CE	N-(2-Acetylphenyl)-4-(6-isoquinolin-2-ium-2-ylhexoxy)benzamide;bromide	Investigative	71456805	C30H31BrN2O3	547.5	CC(=O)C1=CC=CC=C1NC(=O)C2=CC=C(C=C2)OCCCCCC[N+]3=CC4=CC=CC=C4C=C3.[Br-]	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BYGK70	N-{2-Methoxy-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide	Investigative	25138207	C18H18N4O3S	370.4	COC1=C(C=C(C=C1)NC2=NC=NC(=C2)C3=CC=CC=C3)NS(=O)(=O)C	IC50 = 69000 nM	Poor binder
T79031	Beta-secretase 1	BYOQ41	(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-[(2S)-1-amino-1-oxopropan-2-yl]-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid	Investigative	118717560	C24H43F3N8O8	628.6	C[C@@H](C(=O)N)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BYQ1H2	(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[4-[[(2S)-2-[[(2S)-2-Acetamido-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-1-carboxy-2-phenylethyl]amino]-5-oxopentanoic acid	Investigative	56681789	C41H65N7O13S	896.1	C[C@@H]([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)CC(C(CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](C(C)C)NC(=O)C)O)O	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BYQP72	3-[((S)-2-{(3S,4S)-4-[(R)-2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-6-methyl-heptanoylamino}-3-methyl-butyrylamino)-methyl]-benzoic acid	Investigative	44357333	C34H55N5O8S	693.9	CC(C)C[C@@H]([C@H](CC(=O)N[C@@H](C(C)C)C(=O)NCC1=CC(=CC=C1)C(=O)O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)C	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	BZ04AL	Morusin	Investigative	5281671	C25H24O6	420.5	CC(=CCC1=C(OC2=C(C1=O)C(=CC3=C2C=CC(O3)(C)C)O)C4=C(C=C(C=C4)O)O)C	IC50 = 59400 nM	Poor binder
T79031	Beta-secretase 1	BZ1BP2	2-Amino-4-[2-(1H-indol-5-yl)ethyl]-1H-pyrimidin-6-one	Investigative	136236289	C14H14N4O	254.29	C1=CC2=C(C=CN2)C=C1CCC3=CC(=O)NC(=N3)N	IC50 = 130000 nM	Poor binder
T79031	Beta-secretase 1	BZ1CE6	(3S)-3-(2-Amino-5-chlorobenzimidazol-1-yl)-N-[(3-fluorophenyl)methyl]-5-methylhexanamide	Investigative	49864294	C21H24ClFN4O	402.9	CC(C)C[C@@H](CC(=O)NCC1=CC(=CC=C1)F)N2C3=C(C=C(C=C3)Cl)N=C2N	IC50 = 54000 nM	Poor binder
T79031	Beta-secretase 1	BZ1V4S	Byakangelicin	Investigative	10211	C17H18O7	334.3	CC(C)([C@@H](COC1=C2C(=C(C3=C1OC(=O)C=C3)OC)C=CO2)O)O	Ki = 55000 nM	Poor binder
T79031	Beta-secretase 1	BZ32VY	CID 90056348	Investigative	90056348	C14H13BrF2N2O2	359.17	C1C2(CC1(F)F)COC3=C(C24COC(=N4)N)C=C(C=C3)Br	IC50 = 50600 nM	Poor binder
T79031	Beta-secretase 1	BZ5XL8	3-(3-Amino-3-benzyl-4-hydroxybutyl)sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide	Investigative	46881571	C28H34FN3O4S2	559.7	C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC(=CC(=C2)SCCC(CC3=CC=CC=C3)(CO)N)N(C)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BZ78FO	C1=CC2=NC(C)=CN2C=C1C(C=C1C2(N=C(N)OC2)C23Coc3)=CC=C1OC12ccc1	Investigative	90017611	C24H24N4O3	416.5	CC1=CN2C=C(C=CC2=N1)C3=CC4=C(C=C3)OC5(CCC5)C6(C47COC(=N7)N)COC6	IC50 = 96500 nM	Poor binder
T79031	Beta-secretase 1	BZ9NK3	6'-Bromodispiro[cyclobutane-1,3'-chromene-4',4''-[1,3]oxazol]-2''-amine	Investigative	86724233	C14H15BrN2O2	323.18	C1CC2(C1)COC3=C(C24COC(=N4)N)C=C(C=C3)Br	IC50 = 61300 nM	Poor binder
T79031	Beta-secretase 1	BZGF92	[(1S,20R,22S,23R,24R)-7,8,9,12,13,14,23,24-Octahydroxy-4,17-dioxo-2,3,18,21-tetraoxatetracyclo[18.3.1.05,10.011,16]tetracosa-5,7,9,11,13,15-hexaen-22-yl] 3,4,5-trihydroxybenzoate	Investigative	71719654	C27H22O19	650.5	C1[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)O)OOC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O1)O)O)O)O)O)O)O	IC50 ~ 160000 nM	Poor binder
T79031	Beta-secretase 1	BZI9C3	1-(4-Chlorophenyl)-N-(1,3-dihydroxy-1-(4-(methylthio)phenyl)propan-2-yl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide	Investigative	22331258	C28H29ClN2O5S	541.1	CC1(CC2=C(C=C(C(=O)N2C3=CC=C(C=C3)Cl)C(=O)NC(CO)C(C4=CC=C(C=C4)SC)O)C(=O)C1)C	IC50 = 100000 nM	Poor binder
T79031	Beta-secretase 1	BZIK03	Benzyl N-[(2S)-1-[[(2S,3S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid	Investigative	118717584	C36H58F3N7O8	773.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)NC1CCCCC1)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T79031	Beta-secretase 1	BZLY37	N-(2-Acetylphenyl)-4-(5-quinolin-1-ium-1-ylpentoxy)benzamide;bromide	Investigative	71453297	C29H29BrN2O3	533.5	CC(=O)C1=CC=CC=C1NC(=O)C2=CC=C(C=C2)OCCCCC[N+]3=CC=CC4=CC=CC=C43.[Br-]	IC50 = 85000 nM	Poor binder
T79031	Beta-secretase 1	BZR96M	3-[[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2R,3R)-2-Acetamido-3-methylpentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]-3-methylbutanoyl]amino]methyl]benzoic acid	Investigative	56661314	C32H51N5O8	633.8	CC[C@@H](C)[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)N[C@@H](C(C)C)C(=O)NCC1=CC(=CC=C1)C(=O)O)O)NC(=O)C	IC50 ~ 91000 nM	Poor binder
T79031	Beta-secretase 1	D09ROW	IMPERATORIN	Investigative	10212	C16H14O4	270.28	CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C	IC50 = 91800 nM	Poor binder