TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T79570	Aggrecanase-1	B1KYM4	(2R)-2-[[4-(4-Acetamidophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid	Investigative	57400706	C19H22N2O5S	390.5	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C	IC50 = 100000 nM	Poor binder
T79570	Aggrecanase-1	B6C3IU	Biphenylsulfonamide carboxylate, 9	Investigative	24901479	C17H19NO4S	333.4	CC(C)[C@@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T79570	Aggrecanase-1	B6KJ3P	Biphenylsulfonamide carboxylate, 3	Investigative	24901473	C17H19NO4S	333.4	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=CC(=C1)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T79570	Aggrecanase-1	B6XQ9B	Biphenylsulfonamide carboxylate, 5	Investigative	24901475	C17H18N2O6S	378.4	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2[N+](=O)[O-]	IC50 = 50000 nM	Poor binder
T79570	Aggrecanase-1	B95FDH	(2R)-2-[[4-[4-(Cyclohexylmethoxy)phenyl]phenyl]sulfonylamino]-3-methylbutanoic acid	Investigative	57397308	C24H31NO5S	445.6	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)OCC3CCCCC3	IC50 ~ 75000 nM	Poor binder
T79570	Aggrecanase-1	BCX62U	Biphenylsulfonamide carboxylate, 10	Investigative	24901480	C18H21NO4S	347.4	CC(C)C(CC(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 = 100000 nM	Poor binder
T79570	Aggrecanase-1	BOFK26	(2R)-2-[[4-[4-(Benzamidomethyl)phenyl]phenyl]sulfonylamino]-3-methylbutanoic acid	Investigative	57402479	C25H26N2O5S	466.6	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)CNC(=O)C3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T79570	Aggrecanase-1	BPH21T	(2R)-3-Methyl-2-[[4-[4-(methylcarbamoyloxy)phenyl]phenyl]sulfonylamino]butanoic acid	Investigative	57397307	C19H22N2O6S	406.5	CC(C)[C@H](C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)OC(=O)NC	IC50 = 50000 nM	Poor binder
T79570	Aggrecanase-1	BY0T9D	2-(4-Methoxyphenoxy)-N-((5-chloro-8-hydroxyquinolin-7-yl)(4-methoxyphenyl)methyl)acetamide	Investigative	44571675	C26H23ClN2O5	478.9	COC1=CC=C(C=C1)C(C2=CC(=C3C=CC=NC3=C2O)Cl)NC(=O)COC4=CC=C(C=C4)OC	IC50 ~ 50000 nM	Poor binder