TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T80276	PI3-kinase alpha	D0W5HK	Sorafenib	Approved	216239	C21H16ClF3N4O3	464.8	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	D01RYO	Gefitinib	Patented	123631	C22H24ClFN4O3	446.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B0BPU7	3-(2-Acetamido-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-methylbenzamide	Investigative	25129024	C16H15N5O2	309.32	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC(=CC=C3)C(=O)NC	IC50 ~ 50118.72 nM	Poor binder
T80276	PI3-kinase alpha	B0G2HM	2-((4-Fluoro-2-methylphenylamino)methyl)-6-morpholinoisonicotinaldehyde	Investigative	44592217	C18H20FN3O2	329.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C=O)N3CCOCC3	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B0H6BQ	8-Chloro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	66552523	C12H10ClN5O2S	323.76	CS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)Cl	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B0R9BU	6-Methyl-8-(2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one	Investigative	90665816	C21H22N2O3	350.4	CC1=CC=CC=C1OC2=CC(=CC3=C2NC(=CC3=O)N4CCOCC4)C	IC50 = 61000 nM	Poor binder
T80276	PI3-kinase alpha	B0VJ2O	N-(6-Isoquinolin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide	Investigative	66552347	C17H13N5O	303.32	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CN=CC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B1X9QV	2-[(4-Fluoro-2-methylphenoxy)methyl]-N-(2-hydroxyethyl)-6-morpholin-4-ylpyridine-4-carboxamide	Investigative	44592136	C20H24FN3O4	389.4	CC1=C(C=CC(=C1)F)OCC2=NC(=CC(=C2)C(=O)NCCO)N3CCOCC3	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B21LTA	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)isonicotinic acid	Investigative	44592259	C18H20FN3O3	345.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)N3CCC(C3)O	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B21ZLV	6-(2-Morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)-1H-indazol-3-amine	Investigative	71520769	C22H22N8O	414.5	C1CN(C2=NC(=NC(=C21)C3=CC4=C(C=C3)C(=NN4)N)N5CCOCC5)C6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B25PQC	N,N-Dimethyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	59477038	C14H15N5O2S	317.37	CN(C)C1=NN2C=C(C=CC2=N1)C3=CC(=CN=C3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B2EW8I	3-(Phenylethynyl)-1H-indazole	Investigative	20644743	C15H10N2	218.25	C1=CC=C(C=C1)C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B2O3PM	10-(4-Methoxyphenyl)-2-morpholin-4-ylbenzo[g]chromen-4-one	Investigative	134143151	C24H21NO4	387.4	COC1=CC=C(C=C1)C2=C3C(=CC4=CC=CC=C42)C(=O)C=C(O3)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B2OF9R	3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905261	C11H8N6O2	256.22	C1=CC(=CC=C1C2=C3C(=NC=NC3=NN2)N)[N+](=O)[O-]	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B2S0VM	1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine	Investigative	5059890	C19H19N5	317.4	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4C=C3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B2Y9OM	N-Ethyl-N-[(3-phenylpyrido[2,3-b]pyrazin-6-yl)carbamoyl]acetamide	Investigative	16730272	C18H17N5O2	335.4	CCN(C(=O)C)C(=O)NC1=NC2=NC(=CN=C2C=C1)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B3B8QU	6-(6-Methylsulfonylpyridin-3-yl)-1,3-benzothiazol-2-amine	Investigative	122184475	C13H11N3O2S2	305.4	CS(=O)(=O)C1=NC=C(C=C1)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 158489.32 nM	Poor binder
T80276	PI3-kinase alpha	B3CU2L	3-(2-Ethoxynaphthalen-6-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905207	C18H17N5O	319.4	CCOC1=CC2=C(C=C1)C=C(C=C2)C3=NN(C4=NC=NC(=C34)N)C	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B3D1FI	4-[(3-Chloro-2-methylphenyl)methyl]-2-(4-morpholinyl)[1,3]thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione	Investigative	66780844	C17H17ClN4O3S	392.9	CC1=C(C=CC=C1Cl)CN2C3=C(C(=O)NC2=O)SC(=N3)N4CCOCC4	IC50 = 50000 nM	Poor binder
T80276	PI3-kinase alpha	B3Q7NC	3-((3,5-Bis(trifluoromethyl)phenyl)ethynyl)-1Hindazole	Investigative	42606083	C17H8F6N2	354.25	C1=CC2=C(NN=C2C=C1)C#CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B3U2MN	N-[6-(1-Methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552407	C12H12N6O	256.26	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CN(N=C3)C	IC50 ~ 63095.73 nM	Poor binder
T80276	PI3-kinase alpha	B3VMU7	N-Acetyl-N-[5-(4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)pyrimidin-2-yl]acetamide	Investigative	76324822	C19H19N7O3	393.4	CC(=O)N(C1=NC=C(C=N1)C2=NC3=C(C(=N2)N4CCOCC4)N=CC=C3)C(=O)C	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B4CWO6	(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	44578040	C19H22N2O2S	342.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@@H]3C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B4HX3I	1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905171	C12H13N7	255.28	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CN=C3)N	IC50 = 50000 nM	Poor binder
T80276	PI3-kinase alpha	B4QMH0	1-Benzyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905273	C22H17N5	351.4	C1=CC=C(C=C1)CN2C3=NC=NC(=C3C(=N2)C4=CC5=CC=CC=C5C=C4)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B4T5LV	3-(2-Morpholin-4-yl-7-quinolin-6-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol	Investigative	71520675	C25H23N5O2	425.5	C1CN(C2=NC(=NC(=C21)C3=CC(=CC=C3)O)N4CCOCC4)C5=CC6=C(C=C5)N=CC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B59FVI	2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol	Investigative	135947977	C11H9N5O	227.22	C1=CC=C(C(=C1)C2=C3C(=NC=NC3=NN2)N)O	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B59YVI	N-[4-(4-Amino-2H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-phenylbenzamide	Investigative	52949497	C24H18N6O	406.4	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=C5C(=NC=NC5=NN4)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B5BM2F	2-(Benzenesulfonyl)-3-(3,4-dihydro-1H-isoquinolin-2-yl)quinoxaline	Investigative	70689663	C23H19N3O2S	401.5	C1CN(CC2=CC=CC=C21)C3=NC4=CC=CC=C4N=C3S(=O)(=O)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B5J3SY	N-[6-[3-(Benzylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552343	C21H19N5O3S	421.5	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC(=CC=C3)S(=O)(=O)NCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B61VGT	3-((3,5-Difluorophenyl)ethynyl)-1H-indazole	Investigative	42606079	C15H8F2N2	254.23	C1=CC2=C(NN=C2C=C1)C#CC3=CC(=CC(=C3)F)F	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B68KHV	4-(4-Hydroxypiperidin-1-yl)-2-(naphthalen-1-ylmethylamino)-1H-pyrimidin-6-one	Investigative	136229146	C20H22N4O2	350.4	C1CN(CCC1O)C2=CC(=O)NC(=N2)NCC3=CC=CC4=CC=CC=C43	IC50 = 160000 nM	Poor binder
T80276	PI3-kinase alpha	B69WDV	Chembl4295122	Investigative	21270203	C14H11ClO4	278.69	C1=CC(=CC(=C1)Cl)CC(=O)C2=C(C(=C(C=C2)O)O)O	EC50 = 98200 nM	Poor binder
T80276	PI3-kinase alpha	B6B1OC	4-N-Benzyl-6-morpholin-4-ylpyrimidine-2,4-diamine	Investigative	71458543	C15H19N5O	285.34	C1COCCN1C2=NC(=NC(=C2)NCC3=CC=CC=C3)N	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	B6BXY7	2-Methyl-5-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol	Investigative	24889602	C22H23N5O2	389.4	CC1=C(C=C(C=C1)C2=C3CCN(C3=NC(=N2)N4CCOCC4)C5=CC=NC=C5)O	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B6CXI2	1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184540	C22H25N3O2S	395.5	C1CC1CN2C=CC(=CC2=O)C3=CC4=C(C=C3)N=C(S4)NCC5CCOCC5	IC50 ~ 199526.23 nM	Poor binder
T80276	PI3-kinase alpha	B6JS7B	4-((1H-Indazol-3-yl)ethynyl)benzonitrile	Investigative	42606194	C16H9N3	243.26	C1=CC2=C(NN=C2C=C1)C#CC3=CC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B6LVO3	N-[6-[4-(Methylsulfamoyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552298	C15H15N5O3S	345.4	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC=C(C=C3)S(=O)(=O)NC	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B6PBS7	N-[6-[3-(Methanesulfonamido)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclohexanecarboxamide	Investigative	25130429	C20H23N5O3S	413.5	CS(=O)(=O)NC1=CC=CC(=C1)C2=CN3C(=NC(=N3)NC(=O)C4CCCCC4)C=C2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B6RM7P	[2-(Benzylamino)-6-morpholin-4-ylpyridin-4-yl]methanol	Investigative	71462083	C17H21N3O2	299.37	C1COCCN1C2=CC(=CC(=N2)NCC3=CC=CC=C3)CO	IC50 = 119000 nM	Poor binder
T80276	PI3-kinase alpha	B6S3WL	N-(3-Acetylphenyl)-1H-indole-2-carboxamide	Investigative	9209612	C17H14N2O2	278.3	CC(=O)C1=CC(=CC=C1)NC(=O)C2=CC3=CC=CC=C3N2	IC50 = 64000 nM	Poor binder
T80276	PI3-kinase alpha	B72KRX	6-[Cyclopropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71460605	C22H24N4O2	376.5	C1CC1N(CC2=CC=CC3=CC=CC=C32)C4=CC(=NC(=O)N4)N5CCOCC5	IC50 = 76000 nM	Poor binder
T80276	PI3-kinase alpha	B73CND	N-(4-Acetylphenyl)-1H-indole-2-carboxamide	Investigative	26699441	C17H14N2O2	278.3	CC(=O)C1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3N2	IC50 = 61000 nM	Poor binder
T80276	PI3-kinase alpha	B7CJ1P	N-[4-(Methylsulfonylmethyl)-6-morpholin-4-ylpyrimidin-2-yl]-1,2-oxazole-5-carboxamide	Investigative	70694179	C14H17N5O5S	367.38	CS(=O)(=O)CC1=CC(=NC(=N1)NC(=O)C2=CC=NO2)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B7D0OZ	1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184541	C23H27N3O2S	409.5	C[C@H](C1CCOCC1)NC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5	IC50 ~ 199526.23 nM	Poor binder
T80276	PI3-kinase alpha	B7XED2	2-(Pyridin-4-yl)benzo[d]oxazol-5-ol	Investigative	4912089	C12H8N2O2	212.2	C1=CC2=C(C=C1O)N=C(O2)C3=CC=NC=C3	IC50 = 83000 nM	Poor binder
T80276	PI3-kinase alpha	B80UJV	N-[3-Benzoylphenyl]-1h-indole-2-carboxamide	Investigative	56325569	C22H16N2O2	340.4	C1=CC=C(C=C1)C(=O)C2=CC(=CC=C2)NC(=O)C3=CC4=CC=CC=C4N3	IC50 = 55000 nM	Poor binder
T80276	PI3-kinase alpha	B83MYU	Ethyl 2-morpholinoisonicotinate	Investigative	2762944	C12H16N2O3	236.27	CCOC(=O)C1=CC(=NC=C1)N2CCOCC2	IC50 = 51000 nM	Poor binder
T80276	PI3-kinase alpha	B84BVT	2-(Bis(2-hydroxyethyl)amino)-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid	Investigative	44592262	C18H22FN3O4	363.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)N(CCO)CCO	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B86RGZ	3-(2-Morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)benzoic acid	Investigative	59244308	C22H21N5O3	403.4	C1CN(C2=NC(=NC(=C21)C3=CC(=CC=C3)C(=O)O)N4CCOCC4)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B8AW2L	1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905177	C17H21N5O3	343.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C(=C3)OC)OC)OC)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B8I4SD	6-[Ethyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71460604	C21H24N4O2	364.4	CCN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4	IC50 = 82800 nM	Poor binder
T80276	PI3-kinase alpha	B8POJ5	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(piperazin-1-yl)isonicotinic acid	Investigative	44592218	C18H21FN4O2	344.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)N3CCNCC3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B8XS5Q	N-Methyl-3-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-benzenesulfonamide	Investigative	59244961	C22H24N6O3S	452.5	CNS(=O)(=O)C1=CC=CC(=C1)C2=C3CCN(C3=NC(=N2)N4CCOCC4)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	B8ZND1	5-(2-Amino-7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	66552524	C15H17FN6O2S	364.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C=C2F	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	B93BWV	5-(Pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine	Investigative	53319932	C12H9N3	195.22	C1=CNC2=NC=C(C=C21)C3=CC=NC=C3	IC50 = 59000 nM	Poor binder
T80276	PI3-kinase alpha	B98BDU	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxyphenyl)isonicotinic acid	Investigative	44592302	C20H17FN2O3	352.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)C3=CC(=CC=C3)O	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	B9ON0E	4-(3-Methoxyazetidin-1-yl)-2-(naphthalen-1-ylmethylamino)-1H-pyrimidin-6-one	Investigative	136229144	C19H20N4O2	336.4	COC1CN(C1)C2=CC(=O)NC(=N2)NCC3=CC=CC4=CC=CC=C43	IC50 = 82600 nM	Poor binder
T80276	PI3-kinase alpha	B9SPB1	4-Morpholin-4-yl-6-[naphthalen-1-ylmethyl-(3,3,3-trifluoro-2-hydroxypropyl)amino]-1H-pyrimidin-2-one	Investigative	71453424	C22H23F3N4O3	448.4	C1COCCN1C2=NC(=O)NC(=C2)N(CC3=CC=CC4=CC=CC=C43)CC(C(F)(F)F)O	IC50 = 56900 nM	Poor binder
T80276	PI3-kinase alpha	BA59TB	3-(Thiophen-3-ylethynyl)-1H-indazole	Investigative	42606190	C13H8N2S	224.28	C1=CC2=C(NN=C2C=C1)C#CC3=CSC=C3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BABI80	2-(Benzylamino)-6-morpholin-4-yl-1H-pyridin-4-one	Investigative	71454916	C16H19N3O2	285.34	C1COCCN1C2=CC(=O)C=C(N2)NCC3=CC=CC=C3	IC50 = 142000 nM	Poor binder
T80276	PI3-kinase alpha	BAS1T4	6-[3-Hydroxypropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71449776	C22H26N4O3	394.5	C1COCCN1C2=NC(=O)NC(=C2)N(CCCO)CC3=CC=CC4=CC=CC=C43	IC50 = 51500 nM	Poor binder
T80276	PI3-kinase alpha	BAS8F0	5-Fluoro-2-[(1S)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)propyl]-3-[3-(2,2,2-trifluoroethoxy)phenyl]quinazolin-4-one	Investigative	86272388	C25H20F4N6O2	512.5	CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC(=CC=C3)OCC(F)(F)F)NC4=NC=NC5=C4C=CN5	IC50 = 115000 nM	Poor binder
T80276	PI3-kinase alpha	BB1E5A	(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	44578039	C19H22N2O2S	342.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@H]3C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BBCR35	3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905268	C15H15N5	265.31	C1CC2=CC=CC=C2CC1C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BBK16J	4-(4-Morpholin-4-ylpyrido[3,2-d]pyrimidin-2-yl)aniline	Investigative	76335669	C17H17N5O	307.35	C1COCCN1C2=NC(=NC3=C2N=CC=C3)C4=CC=C(C=C4)N	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BBR4Y5	6-[(2,3-Dichlorophenyl)methylamino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71449565	C15H16Cl2N4O2	355.2	C1COCCN1C2=NC(=O)NC(=C2)NCC3=C(C(=CC=C3)Cl)Cl	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BBV89X	4-[2-(3-Methoxyphenyl)pyrido[3,2-d]pyrimidin-4-yl]morpholine	Investigative	76317467	C18H18N4O2	322.4	COC1=CC=CC(=C1)C2=NC3=C(C(=N2)N4CCOCC4)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BBWU45	6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905227	C19H18N6O	346.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)NC(=O)C=C5)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BBX8V0	6-(Benzylamino)-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71449564	C15H18N4O2	286.33	C1COCCN1C2=NC(=O)NC(=C2)NCC3=CC=CC=C3	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BC23WJ	3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905246	C15H15N7	293.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN4C=C3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BC34RP	4-(3-Phenylsulfanylquinoxalin-2-yl)morpholine	Investigative	90667919	C18H17N3OS	323.4	C1COCCN1C2=NC3=CC=CC=C3N=C2SC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BD0Z9Q	4-[4-(1H-Indazol-4-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine	Investigative	71520770	C22H21N7O	399.4	C1CN(C2=NC(=NC(=C21)C3=C4C=NNC4=CC=C3)N5CCOCC5)C6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BD1GK8	(1-(7-Fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl)-6-morpholinoindoline-3,3-diyl)dimethanol	Investigative	67285457	C29H29FN4O3	500.6	CC1=C(C2=C(C=C(C=C2)F)N=C1C3=CC=CC=N3)N4CC(C5=C4C=C(C=C5)N6CCOCC6)(CO)CO	Ki ~ 125000 nM	Poor binder
T80276	PI3-kinase alpha	BD4B2E	1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905178	C16H19N5O2	313.35	CC(C)N1C2=NC=NC(=C2C(=N1)C3=C(C(=CC=C3)OC)OC)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BD4NB2	N-Methyl-N-[6-(3-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552410	C16H16N4O3S	344.4	CC(=O)N(C)C1=NN2C=C(C=CC2=N1)C3=CC(=CC=C3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BD6AQ8	1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184542	C23H27N3O2S	409.5	C[C@@H](C1CCOCC1)NC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5	IC50 ~ 199526.23 nM	Poor binder
T80276	PI3-kinase alpha	BDR9I6	1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184543	C22H25N3O3S2	443.6	C1CC1CN2C=CC(=CC2=O)C3=CC4=C(C=C3)N=C(S4)NCC5CCS(=O)(=O)CC5	IC50 = 79432.82 nM	Poor binder
T80276	PI3-kinase alpha	BE7U0D	2-(4-Chlorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone	Investigative	4583262	C14H11ClO4	278.69	C1=CC(=CC=C1CC(=O)C2=C(C(=C(C=C2)O)O)O)Cl	EC50 = 69300 nM	Poor binder
T80276	PI3-kinase alpha	BF2W8Z	4-[6-(2-Pyrazin-2-ylethylsulfonylmethyl)-2-pyridin-2-ylpyrimidin-4-yl]morpholine	Investigative	58137111	C20H22N6O3S	426.5	C1COCCN1C2=NC(=NC(=C2)CS(=O)(=O)CCC3=NC=CN=C3)C4=CC=CC=N4	IC50 ~ 90000 nM	Poor binder
T80276	PI3-kinase alpha	BF35LM	1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	52944356	C18H15N5	301.3	CN1C2=NC=NC(=C2C(=N1)C3=CC=CC(=C3)C4=CC=CC=C4)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BF56ON	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyethylamino)isonicotinic acid	Investigative	44592261	C16H18FN3O3	319.33	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)NCCO	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BF84GU	N-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanesulfonamide	Investigative	58024825	C17H22N4O5S2	426.5	CS(=O)(=O)CC1=CC(=NC(=N1)C2=CC=C(C=C2)NS(=O)(=O)C)N3CCOCC3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BFM2Y6	6-[2-Hydroxybutyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71460607	C23H28N4O3	408.5	CCC(CN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4)O	IC50 = 149000 nM	Poor binder
T80276	PI3-kinase alpha	BFP23L	4-[4-(1H-Indazol-5-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine	Investigative	71520768	C22H21N7O	399.4	C1CN(C2=NC(=NC(=C21)C3=CC4=C(C=C3)NN=C4)N5CCOCC5)C6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BFQ45P	trans-4-[[[6-[1-(Cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-cyclohexanecarboxylic acid	Investigative	122184544	C24H27N3O3S	437.6	C1CC(CCC1CNC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5)C(=O)O	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BGEP17	3-[3-(Dimethylamino)-1-propynyl]-1H-indazole	Investigative	49852123	C12H13N3	199.25	CN(C)CC#CC1=C2C=CC=CC2=NN1	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BGPS06	N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552467	C15H15N5O3S	345.4	CC1=CC2=NC(=NN2C=C1C3=CC(=CN=C3)S(=O)(=O)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BH3GY7	4-Morpholin-4-yl-6-[[(1S)-1-naphthalen-1-ylethyl]amino]-1H-pyrimidin-2-one	Investigative	71451372	C20H22N4O2	350.4	C[C@@H](C1=CC=CC2=CC=CC=C21)NC3=CC(=NC(=O)N3)N4CCOCC4	IC50 = 52800 nM	Poor binder
T80276	PI3-kinase alpha	BH61RX	4-Morpholin-4-yl-6-[[(1R)-1-naphthalen-1-ylethyl]amino]-1H-pyrimidin-2-one	Investigative	71458545	C20H22N4O2	350.4	C[C@H](C1=CC=CC2=CC=CC=C21)NC3=CC(=NC(=O)N3)N4CCOCC4	IC50 = 146000 nM	Poor binder
T80276	PI3-kinase alpha	BH8LE3	2-Pyridin-4-yl-benzooxazol-5-ylamine	Investigative	736009	C12H9N3O	211.22	C1=CC2=C(C=C1N)N=C(O2)C3=CC=NC=C3	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BHAX60	2-((4-Fluoro-2-methylphenylamino)methyl)-6-((2-hydroxyethyl)(methyl)amino)isonicotinic acid	Investigative	44592260	C17H20FN3O3	333.36	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)N(C)CCO	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BHM36E	6-[3-(Dimethylamino)propyl-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71455125	C24H31N5O2	421.5	CN(C)CCCN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BHMW36	5-(Pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine	Investigative	53318614	C10H8N6	212.21	C1=CN=CC=C1C2=NC3=NC(=NN3C=C2)N	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BI0N1E	Chembl4292760	Investigative	145988761	C15H11F3O4	312.24	C1=CC(=CC=C1CC(=O)C2=C(C(=C(C=C2)O)O)O)C(F)(F)F	EC50 = 58400 nM	Poor binder
T80276	PI3-kinase alpha	BI84XJ	2-Methyl-3-(2-morpholin-4-yl-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)phenol	Investigative	24889603	C22H23N5O2	389.4	CC1=C(C=CC=C1O)C2=C3CCN(C3=NC(=N2)N4CCOCC4)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BI9C3M	2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone	Investigative	586366	C14H11ClO3	262.69	C1=CC(=CC=C1CC(=O)C2=C(C=C(C=C2)O)O)Cl	EC50 = 196000 nM	Poor binder
T80276	PI3-kinase alpha	BIZ01Y	2-(Aminomethyl)-N-benzyl-6-morpholin-4-ylpyrimidin-4-amine	Investigative	71454917	C16H21N5O	299.37	C1COCCN1C2=NC(=NC(=C2)NCC3=CC=CC=C3)CN	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BJT7O1	2-Chloro-6-((4-fluoro-2-methylphenylamino)methyl)isonicotinic acid	Investigative	44592338	C14H12ClFN2O2	294.71	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BK0MV6	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(4-hydroxyphenyl)isonicotinic acid	Investigative	135986100	C20H17FN2O3	352.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)C3=CC=C(C=C3)O	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BKNW03	4-(1-(7-Fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-6-methyl-2-pyrimidinamine	Investigative	50938829	C30H27FN6	490.6	CC1=CC(=NC(=N1)N)C2=CC3=C(C=C2)C(CN3C4=C(C(=NC5=C4C=CC(=C5)F)C6=CC=CC=N6)C)(C)C	Ki ~ 125000 nM	Poor binder
T80276	PI3-kinase alpha	BL8KB0	6-[4-Hydroxybutyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71460606	C23H28N4O3	408.5	C1COCCN1C2=NC(=O)NC(=C2)N(CCCCO)CC3=CC=CC4=CC=CC=C43	IC50 = 73700 nM	Poor binder
T80276	PI3-kinase alpha	BLIS49	Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate	Investigative	24905187	C23H26N6O2	418.5	CC(C)(C)OC(=O)N1C=CC2=C1C=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCC5	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BLY40Q	3-[4-(4,4-Difluoropiperidin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol	Investigative	76335667	C18H16F2N4O	342.3	C1CN(CCC1(F)F)C2=NC(=NC3=C2N=CC=C3)C4=CC(=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BM24CI	3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905265	C18H13Cl2N5O	386.2	C1=CC(=CC(=C1)OCC2=C(C=CC=C2Cl)Cl)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BM6SL9	6-[2-Hydroxypropyl(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71455124	C22H26N4O3	394.5	CC(CN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4)O	IC50 = 112000 nM	Poor binder
T80276	PI3-kinase alpha	BM76KW	8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one	Investigative	17756679	C20H28N4O4	388.5	CC1=C(C=CC2=C1OC(=NC2=O)N3CCOCC3)OCCN4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BMGN80	6-Pyrimidin-2-yl-1,3-benzothiazol-2-amine	Investigative	122184482	C11H8N4S	228.28	C1=CN=C(N=C1)C2=CC3=C(C=C2)N=C(S3)N	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BMP9Y2	4-Morpholin-4-yl-6-(naphthalen-1-ylmethylamino)-1H-pyrimidin-2-one	Investigative	70675845	C19H20N4O2	336.4	C1COCCN1C2=NC(=O)NC(=C2)NCC3=CC=CC4=CC=CC=C43	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BNMX13	2-((1H-Indazol-3-yl)ethynyl)aniline	Investigative	21048651	C15H11N3	233.27	C1=CC=C(C(=C1)C#CC2=C3C=CC=CC3=NN2)N	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BNX13Z	6-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905226	C17H16N6O	320.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)NC(=O)C=C4)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BO40RN	3-(Pyridin-2-ylethynyl)-1H-indazole	Investigative	42606191	C14H9N3	219.24	C1=CC=NC(=C1)C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BOH29Z	2-((4-Fluoro-2-methylphenylamino)methyl)-N-(2-hydroxyethyl)-6-(2-hydroxyethylamino)isonicotinamide	Investigative	44592339	C18H23FN4O3	362.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)NCCO)NCCO	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BOM52F	6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine	Investigative	122184468	C14H14N4S	270.35	CNCC1=NC=C(C=C1)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 63095.73 nM	Poor binder
T80276	PI3-kinase alpha	BOVT82	5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905299	C17H19ClN6O	358.8	C1CC(CNC1)CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BPIU71	2-(4-Chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanone	Investigative	592738	C14H11ClO4	278.69	C1=CC(=CC=C1CC(=O)C2=C(C=C(C=C2O)O)O)Cl	EC50 = 79300 nM	Poor binder
T80276	PI3-kinase alpha	BPQ0R9	N-[6-(3-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	25128668	C15H14N4O2	282.3	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC(=CC=C3)OC	IC50 ~ 79432.82 nM	Poor binder
T80276	PI3-kinase alpha	BQN24X	N-[6-(3-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	25132804	C15H14N4O3S	330.4	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC(=CC=C3)S(=O)(=O)C	IC50 ~ 50118.72 nM	Poor binder
T80276	PI3-kinase alpha	BQTP35	3-(Cyclopropylethynyl)-1H-indazole	Investigative	42606195	C12H10N2	182.22	C1CC1C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BR0Y9C	3-[4-(4-Methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol	Investigative	76310247	C18H19N5O	321.4	CN1CCN(CC1)C2=NC(=NC3=C2N=CC=C3)C4=CC(=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BR4XO3	N-[6-[3-(Benzylsulfamoyl)-4-methoxyphenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552346	C22H21N5O4S	451.5	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC(=C(C=C3)OC)S(=O)(=O)NCC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BR87QP	2-(4-Fluorophenyl)-1-(2,3,4-trihydroxyphenyl)ethanone	Investigative	796828	C14H11FO4	262.23	C1=CC(=CC=C1CC(=O)C2=C(C(=C(C=C2)O)O)O)F	EC50 = 170400 nM	Poor binder
T80276	PI3-kinase alpha	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BSP8M1	N-[2-Methyl-6-[2-[(1-methylpyrazol-3-yl)amino]-6-(1-propan-2-ylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]acetamide	Investigative	62706816	C24H26N10O	470.5	CC1=NC(=CC(=N1)NC(=O)C)C2=C(N=C3N2C=C(C=C3)C4=CN(N=C4)C(C)C)NC5=NN(C=C5)C	IC50 ~ 125000 nM	Poor binder
T80276	PI3-kinase alpha	BT5H2Q	3-(Cyclopentylethynyl)-1H-indazole	Investigative	42606196	C14H14N2	210.27	C1CCC(C1)C#CC2=C3C=CC=CC3=NN2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BT6N0R	3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905262	C17H13N5O	303.32	C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BT6RY0	3-(4-Fluorophenyl)-7,8-dihydroxychromen-4-one	Investigative	5407855	C15H9FO4	272.23	C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3O)O)F	EC50 = 139600 nM	Poor binder
T80276	PI3-kinase alpha	BT7B6U	3-[4-(1,1-Dioxo-1,4-thiazinan-4-yl)pyrido[3,2-d]pyrimidin-2-yl]phenol	Investigative	76317466	C17H16N4O3S	356.4	C1CS(=O)(=O)CCN1C2=NC(=NC3=C2N=CC=C3)C4=CC(=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BUX4Z5	4-[4-(1H-Indazol-7-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine	Investigative	71520868	C22H21N7O	399.4	C1CN(C2=NC(=NC(=C21)C3=CC=CC4=C3NN=C4)N5CCOCC5)C6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BUYJ59	6-((4-Fluoro-2-methylphenylamino)methyl)-2,3''-bipyridine-4-carboxylic acid	Investigative	44592300	C19H16FN3O2	337.3	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)C3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BV1KC7	4-[4-(1H-Indazol-6-yl)-7-pyridin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholine	Investigative	71520767	C22H21N7O	399.4	C1CN(C2=NC(=NC(=C21)C3=CC4=C(C=C3)C=NN4)N5CCOCC5)C6=CC=NC=C6	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BV20QA	3-(2-Morpholin-4-yl-7-pyridin-2-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenol	Investigative	24889437	C21H21N5O2	375.4	C1CN(C2=NC(=NC(=C21)C3=CC(=CC=C3)O)N4CCOCC4)C5=CC=CC=N5	IC50 ~ 50000 nM	Poor binder
T80276	PI3-kinase alpha	BV7KC1	6-[2-(Dimethylamino)ethyl-(naphthalen-1-ylmethyl)amino]-4-morpholin-4-yl-1H-pyrimidin-2-one	Investigative	71451588	C23H29N5O2	407.5	CN(C)CCN(CC1=CC=CC2=CC=CC=C21)C3=CC(=NC(=O)N3)N4CCOCC4	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BVH06P	N-[5-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	59477042	C15H15N5O3S	345.4	CC1=C(C=CC2=NC(=NN12)NC(=O)C)C3=CC(=CN=C3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BVW6G4	2-(Naphthalen-1-ylmethylamino)-4-(1H-pyrazol-4-yl)-1H-pyrimidin-6-one	Investigative	136229148	C18H15N5O	317.3	C1=CC=C2C(=C1)C=CC=C2CNC3=NC(=CC(=O)N3)C4=CNN=C4	IC50 = 62300 nM	Poor binder
T80276	PI3-kinase alpha	BVZ6U3	N-Benzyl-6-morpholinopyrimidin-4-amine	Investigative	24880629	C15H18N4O	270.33	C1COCCN1C2=NC=NC(=C2)NCC3=CC=CC=C3	IC50 ~ 83300 nM	Poor binder
T80276	PI3-kinase alpha	BW20GR	N-[6-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	25129383	C15H14N4O2	282.3	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC=CC=C3OC	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BW34XQ	N-[6-(4-Methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552297	C15H14N4O3S	330.4	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC=C(C=C3)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BWB36A	2-{[4-Amino-3-(3-Hydroxyprop-1-Yn-1-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-1-Yl]methyl}-5-Methyl-3-(2-Methylphenyl)quinazolin-4(3h)-One	Investigative	44475987	C25H21N7O2	451.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C#CCO)N	IC50 = 85000 nM	Poor binder
T80276	PI3-kinase alpha	BWN2Z4	(2-((4-Fluoro-2-methylphenylamino)methyl)-6-(3-hydroxypyrrolidin-1-yl)pyridin-4-yl)(3-hydroxypyrrolidin-1-yl)methanone	Investigative	44592340	C22H27FN4O3	414.5	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)N3CCC(C3)O)N4CCC(C4)O	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BWS24D	3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905267	C17H13N5	287.32	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BX5CQ8	6-(5-Methylsulfonylpyridin-3-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	66552468	C13H10F3N5O2S	357.31	CS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BXP7W4	N-[6-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]methanesulfonamide	Investigative	66552412	C13H13N5O4S2	367.4	CS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)NS(=O)(=O)C)C=C2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BXW73J	5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905308	C21H15FN6O2	402.4	C1=CC=C(C=C1)C2=C(OC=N2)CN3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)F)O)N	IC50 = 100000 nM	Poor binder
T80276	PI3-kinase alpha	BY95HQ	2-((4-Fluoro-2-methylphenylamino)methyl)-6-(2-hydroxyphenyl)isonicotinic acid	Investigative	135986101	C20H17FN2O3	352.4	CC1=C(C=CC(=C1)F)NCC2=NC(=CC(=C2)C(=O)O)C3=CC=CC=C3O	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BYWH65	1-[6-[5-(Tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-phenylurea	Investigative	70686339	C22H23N7O3S	465.5	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)NC(=O)NC4=CC=CC=C4)C=C2	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	BZ3XS9	N-(4-Benzoylphenyl)-1h-indole-2-carboxamide	Investigative	127047042	C22H16N2O2	340.4	C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)NC(=O)C3=CC4=CC=CC=C4N3	IC50 = 54000 nM	Poor binder
T80276	PI3-kinase alpha	D00ZIK	IC87114	Investigative	9908783	C22H19N7O	397.4	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C(N=CN=C54)N	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	D0N2LW	8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one	Investigative	11324758	C19H17NO2S	323.4	C1CSCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	D0Q5FJ	8-Phenyl-2-piperidin-1-yl-chromen-4-one	Investigative	11185819	C20H19NO2	305.4	C1CCN(CC1)C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T80276	PI3-kinase alpha	D0T0BY	2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one	Investigative	10039361	C16H15N3O2	281.31	C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder