TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T82393	TNF alpha converting enzyme	D0E5GY	RO-319790	Terminated	9904965	C15H29N3O4	315.41	CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)NC)C(C)(C)C	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	B0W8EH	5-Methyl-5-[6-(2-methyl-quinolin-4-ylmethoxy)-naphthalen-2-yl]-pyrimidine-2,4,6-trione	Investigative	44399509	C26H21N3O4	439.5	CC1=NC2=CC=CC=C2C(=C1)COC3=CC4=C(C=C3)C=C(C=C4)C5(C(=O)NC(=O)NC5=O)C	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	B1A4XI	Rac-3-(2-(4-(but-2-ynyloxy)phenylsulfonamido)-2-carboxyethyl)-1-methyl-1H-indole-5-carboxylic acid	Investigative	44592661	C23H22N2O7S	470.5	CC#CCOC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CN(C3=C2C=C(C=C3)C(=O)O)C)C(=O)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	B1L0CN	(5S)-4-(Cyclobutylmethyl)-1-[(2S)-1-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)propan-2-yl]-5-[(4-hydroxyphenyl)methyl]piperazine-2,3-dione	Investigative	122181849	C37H49N5O6	659.8	CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]2CCCN2C[C@H](CC3=CC=C(C=C3)O)N4C[C@@H](N(C(=O)C4=O)CC5CCC5)CC6=CC=C(C=C6)O	IC50 = 94000 nM	Poor binder
T82393	TNF alpha converting enzyme	B2T7CH	N-Hydroxy-2-(2-(4-methoxyphenylsulfonyl)phenyl)acetamide	Investigative	44478926	C15H15NO5S	321.3	COC1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2CC(=O)NO	IC50 = 67000 nM	Poor binder
T82393	TNF alpha converting enzyme	B2T8FB	5-(4-Benzyloxy-phenyl)-5-methyl-pyrimidine-2,4,6-trione	Investigative	44399312	C18H16N2O4	324.3	CC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	B38BVD	beta-Sulfonyl hydroxamate analogue, 11	Investigative	24860420	C23H33N3O6S	479.6	CC#CCN(C)C1=CC=C(C=C1)S(=O)(=O)CC2(CCN(CC2)C(=O)OC(C)(C)C)C(=O)NO	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	B4L1BH	Methyl (1S,3R)-6-{3-fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-methyl-4-oxo-5-azaspiro[2.4]heptane-1-carboxylate	Investigative	25138243	C31H27FN2O4	510.6	CN1C(C[C@]2(C1=O)C[C@@H]2C(=O)OC)C3=CC(=C(C=C3)OCC4=CC(=NC5=CC=CC=C54)C6=CC=CC=C6)F	Ki ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	B4T1PU	N-Hydroxy-2-(N-isobutylbiphenyl-4-ylsulfonamido)acetamide	Investigative	45269631	C18H22N2O4S	362.4	CC(C)CN(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 = 53000 nM	Poor binder
T82393	TNF alpha converting enzyme	B4ZMA2	CID 66560022	Investigative	66560022	C30H32N8O2S3	632.8	C=CCCNC1=NC(=NC(=N1)N2CCC[C@@H]2CNS(=O)(=O)C3=CC4=CC=CC=C4C=C3)NCC5=CSC(=N5)C6=CC=CS6	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	B5P1MN	2-[2-[4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]phenyl]sulfonylphenyl]-N-hydroxyacetamide	Investigative	127037444	C25H22N2O7S	494.5	C1=CC=C(C(=C1)CC(=O)NO)S(=O)(=O)C2=CC=C(C=C2)OCCCN3C(=O)C4=CC=CC=C4C3=O	IC50 = 150000 nM	Poor binder
T82393	TNF alpha converting enzyme	B7BO0U	(2R,4S)-1-[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl-N,4-dihydroxypiperidine-2-carboxamide	Investigative	15541746	C19H21ClN2O6S	440.9	C1CN([C@H](C[C@H]1O)C(=O)NO)S(=O)(=O)C2=CC=C(C=C2)OCC3=CC=C(C=C3)Cl	IC50 = 58000 nM	Poor binder
T82393	TNF alpha converting enzyme	B8FS4Q	(2R)-2-[[4-[4-[(4-Chlorophenyl)methoxy]phenyl]phenyl]sulfonyl-propan-2-yloxyamino]-N-hydroxy-3-methylbutanamide	Investigative	44220093	C27H31ClN2O6S	547.1	CC(C)[C@H](C(=O)NO)N(OC(C)C)S(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)OCC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BA14DV	(3S,6R,7S)-6-Hexyl-7-(hydroxyaminocarbonyl)-5-oxo-11-oxa-4-azabicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-3-carboxylic acid methyl ester	Investigative	11091368	C23H34N2O6	434.5	CCCCCC[C@@H]1[C@H](CCCOC2=CC=C(C[C@H](NC1=O)C(=O)OC)C=C2)C(=O)NO	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	BAZS45	5-(4-Fluorophenyl)-5-[(3-oxo-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-yl)methyl]imidazolidine-2,4-dione	Investigative	46881488	C16H17FN4O3	332.33	C1CC2CN(C(=O)N2C1)CC3(C(=O)NC(=O)N3)C4=CC=C(C=C4)F	Ki ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	BB5SG2	(5S)-4-[2-(1-Adamantyl)ethyl]-5-[(4-hydroxyphenyl)methyl]-1-[(2R)-1-[(2S)-2-[[(6R)-6-[(4-hydroxyphenyl)methyl]-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]piperazine-2,3-dione	Investigative	122181997	C52H61N5O6	852.1	C1C[C@H](N(C1)C[C@@H](CC2=CC3=CC=CC=C3C=C2)N4C[C@@H](N(C(=O)C4=O)CCC56CC7CC(C5)CC(C7)C6)CC8=CC=C(C=C8)O)CN9[C@@H](CNC(=O)C9=O)CC1=CC=C(C=C1)O	IC50 = 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BD20NB	2-[[4-[(3,5-Dibromophenyl)methoxy]phenyl]sulfonylamino]acetic acid	Investigative	72714084	C15H13Br2NO5S	479.1	C1=CC(=CC=C1OCC2=CC(=CC(=C2)Br)Br)S(=O)(=O)NCC(=O)O	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	BD2V9Y	N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide	Investigative	54589400	C20H27N5O4	401.5	CNC(=O)[C@H](CC1=CN=CN1)NC(=O)CN(CCCC2=CC=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BD6R7T	(2R,5R)-1-[4-[(3-Cyanophenyl)methoxy]phenyl]sulfonyl-N,5-dihydroxypiperidine-2-carboxamide	Investigative	44278455	C20H21N3O6S	431.5	C1C[C@@H](N(C[C@@H]1O)S(=O)(=O)C2=CC=C(C=C2)OCC3=CC(=CC=C3)C#N)C(=O)NO	IC50 = 63000 nM	Poor binder
T82393	TNF alpha converting enzyme	BF6JZ9	CID 66559934	Investigative	66559934	C27H29F3N8O2S3	650.8	C=CCCNC1=NC(=NC(=N1)N2CCC[C@@H]2CNS(=O)(=O)C3=CC=C(C=C3)C(F)(F)F)NCC4=CSC(=N4)C5=CC=CS5	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	BJ2YI8	Cruzain-IN-1	Investigative	44143088	C14H10F2N6	300.27	CCN1C=NC2=C(N=C(N=C21)C#N)NC3=CC(=CC(=C3)F)F	IC50 = 74131.02 nM	Poor binder
T82393	TNF alpha converting enzyme	BNH40K	trans-2-Aminocyclohexylcarbamoylphosphonic acid	Investigative	24807817	C7H15N2O4P	222.18	C1CC[C@H]([C@@H](C1)N)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BNM49T	Rac-3-(2-(4-(but-2-ynyloxy)phenylsulfonamido)-2-carboxyethyl)-1-ethyl-1H-indole-5-carboxylic acid	Investigative	44592662	C24H24N2O7S	484.5	CCN1C=C(C2=C1C=CC(=C2)C(=O)O)CC(C(=O)O)NS(=O)(=O)C3=CC=C(C=C3)OCC#CC	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BOG9H0	(2R,4S)-1-[4-[(4-Cyanophenyl)methoxy]phenyl]sulfonyl-N,4-dihydroxypiperidine-2-carboxamide	Investigative	44278532	C20H21N3O6S	431.5	C1CN([C@H](C[C@H]1O)C(=O)NO)S(=O)(=O)C2=CC=C(C=C2)OCC3=CC=C(C=C3)C#N	IC50 = 77000 nM	Poor binder
T82393	TNF alpha converting enzyme	BON9H8	Rac-1-benzyl-3-(2-(4-(but-2-ynyloxy)phenylsulfonamido)-2-carboxyethyl)-1H-indole-5-carboxylic acid	Investigative	44592663	C29H26N2O7S	546.6	CC#CCOC1=CC=C(C=C1)S(=O)(=O)NC(CC2=CN(C3=C2C=C(C=C3)C(=O)O)CC4=CC=CC=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BPAN37	Methyl (1R,2S)-2-(hydroxycarbamoyl)-1-({4-[2-(naphthalen-2-yl)ethoxy]phenyl}methyl)cyclopropane-1-carboxylate	Investigative	24799953	C25H25NO5	419.5	COC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCCC3=CC4=CC=CC=C4C=C3	Ki ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BT12UN	2-{Isopropoxy[(4-methoxyphenyl)sulfonyl]amino}-N-hydroxyacetamide	Investigative	44423677	C12H18N2O6S	318.35	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)OC	IC50 = 180000 nM	Poor binder
T82393	TNF alpha converting enzyme	BU6P4L	5-(4-Hydroxy-phenyl)-5-methyl-barbituric acid	Investigative	44399294	C11H10N2O4	234.21	CC1(C(=O)NC(=O)NC1=O)C2=CC=C(C=C2)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BV2IK6	Methyl (1R,2S)-2-(hydroxycarbamoyl)-1-({4-[2-(naphthalen-1-yl)ethoxy]phenyl}methyl)cyclopropane-1-carboxylate	Investigative	24799952	C25H25NO5	419.5	COC(=O)[C@]1(C[C@@H]1C(=O)NO)CC2=CC=C(C=C2)OCCC3=CC=CC4=CC=CC=C43	Ki ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	BV74OF	CID 66560021	Investigative	66560021	C29H36N8O2S3	624.9	CCCC1=CC=C(C=C1)S(=O)(=O)NC[C@H]2CCCN2C3=NC(=NC(=N3)NCC4=CSC(=N4)C5=CC=CS5)NCCC=C	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	BVW4I9	2-[(5-Bromothiophen-2-yl)sulfonyl-propan-2-yloxyamino]-N-hydroxyacetamide	Investigative	127037446	C9H13BrN2O5S2	373.2	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(S1)Br	IC50 = 114000 nM	Poor binder
T82393	TNF alpha converting enzyme	BX93MJ	(2S,5S)-N,5-Dihydroxy-1-(4-(2-iodobenzyloxy)phenylsulfonyl)piperidine-2-carboxamide	Investigative	44564504	C19H21IN2O6S	532.4	C1C[C@H](N(C[C@H]1O)S(=O)(=O)C2=CC=C(C=C2)OCC3=CC=CC=C3I)C(=O)NO	IC50 = 110000 nM	Poor binder
T82393	TNF alpha converting enzyme	BZV5M6	beta-Sulfonyl hydroxamate analogue, 28	Investigative	24860430	C22H32N2O7S2	500.6	CC#CC(C)(C)OC1=CC=C(C=C1)S(=O)(=O)CC2(CCN(CC2)S(=O)(=O)C(C)C)C(=O)NO	IC50 ~ 50000 nM	Poor binder
T82393	TNF alpha converting enzyme	D0B3UN	RXP470.1	Investigative	44580458	C35H35BrClN4O10P	818	C1=CC(=CC(=C1)Cl)C2=CC=C(C=C2)C3=NOC(=C3)C[C@H](CP(=O)(C4=CC=C(C=C4)Br)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N	Ki ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	D0G3YZ	(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid	Investigative	11391583	C17H18O3	270.32	C1=CC=C(C=C1)C2=CC=C(C=C2)CCC(CC(=O)O)O	IC50 ~ 98000 nM	Poor binder
T82393	TNF alpha converting enzyme	D0Q4TA	ARP100	Investigative	10044321	C17H20N2O5S	364.4	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	D0T1FR	Cis-2-aminocyclohexylcarbamoylphosphonic acid	Investigative	44457233	C7H15N2O4P	222.18	C1CC[C@H]([C@H](C1)N)NC(=O)P(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T82393	TNF alpha converting enzyme	D0Y1XM	2-(benzyloxyamino)-N-hydroxyhexanamide	Investigative	44423686	C13H20N2O3	252.31	CCCCC(C(=O)NO)NOCC1=CC=CC=C1	IC50 = 100000 nM	Poor binder