TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T83369	Coagulation factor IX	B0OD4G	Methyl N-[4-[2-[(1S)-1-[[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-2-phenylethyl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	57976446	C29H25ClN8O3	569	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@H](CC3=CC=CC=C3)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki ~ 60000 nM	Poor binder
T83369	Coagulation factor IX	B1NZ5J	2-Chloro-N-[2-(7-hydroxy-4-methyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736112	C19H17ClN6O2	396.8	CC1=C2C(=C(C=C1)O)NC(=N2)CCNC(=O)C3=C(C=C(C=C3)N4C=NN=C4)Cl	Ki = 131000 nM	Poor binder
T83369	Coagulation factor IX	B28LHJ	(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid	Investigative	71720404	C43H48F3N9O8S	908	C1CN2CCN1CC(=O)NC3=CC=C(C[C@H](C(=O)N[C@@H](CC4=CC=C(C=C4)NC(=O)C2)C(=O)NCC5=CC=C(C=C5)C(=N)N)NS(=O)(=O)CC6=CC=CC=C6)C=C3.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	B3BU1S	2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(triazol-2-yl)benzamide	Investigative	118736122	C20H19ClN6O	394.9	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=C(C=C(C=C3)N4N=CC=N4)Cl	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	B3D7RA	N-[2-(5,6-Dimethyl-1H-benzimidazol-2-yl)ethyl]-2-(1,2,4-triazol-4-yl)benzamide	Investigative	118736113	C20H20N6O	360.4	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=CC=CC=C3N4C=NN=C4	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	B3H8WP	N-[[(3S,3Ar)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzothiazin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713018	C20H18ClN3O5S2	480	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CS3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	B5VU7B	N-[(1s)-1-Benzyl-2-[2-[5-Chloro-2-(Tetrazol-1-Yl)phenyl]ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2-Oxo-1h-Quinoline-6-Carboxamide	Investigative	59402011	C28H24ClN7O4	558	C1=CC=C(C=C1)C[C@@H](C(=O)NCCC2=C(C=CC(=C2)Cl)N3C=NN=N3)NC(=O)C4=CC5=C(C=C4)NC(=O)C=C5O	Ki ~ 73000 nM	Poor binder
T83369	Coagulation factor IX	B6DO2F	N-[2-(1H-Benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736105	C18H16N6O	332.4	C1=CC=C2C(=C1)NC(=N2)CCNC(=O)C3=CC=C(C=C3)N4C=NN=C4	Ki = 114000 nM	Poor binder
T83369	Coagulation factor IX	B6YB2G	2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]benzamide	Investigative	118736118	C18H18ClN3O	327.8	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=CC=CC=C3Cl	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	B76YIG	N-[2-(4-Methyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736110	C19H18N6O	346.4	CC1=C2C(=CC=C1)NC(=N2)CCNC(=O)C3=CC=C(C=C3)N4C=NN=C4	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	B8EXP3	2-({(1S,2S)-1-[(S)-1-(4-Carbamimidoyl-benzylcarbamoyl)-3-carbamoyl-propylcarbamoyl]-2-methyl-butylsulfamoyl}-methyl)-benzoic acid	Investigative	44587263	C27H36N6O7S	588.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NCC1=CC=C(C=C1)C(=N)N)NS(=O)(=O)CC2=CC=CC=C2C(=O)O	Ki ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	B9IR2P	4-Hydroxy-5-phenyl-1H-pyrazole-3-carboxylic acid (4-carbamimidoyl-phenyl)-amide	Investigative	54726725	C17H15N5O2	321.33	C1=CC=C(C=C1)C2=NNC(=C2O)C(=O)NC3=CC=C(C=C3)C(=N)N	Ki = 120000 nM	Poor binder
T83369	Coagulation factor IX	BAMY07	N-[2-(6-Methoxy-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736109	C19H18N6O2	362.4	COC1=CC2=C(C=C1)N=C(N2)CCNC(=O)C3=CC=C(C=C3)N4C=NN=C4	Ki = 86600 nM	Poor binder
T83369	Coagulation factor IX	BDAJ86	N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	76685067	C20H18ClN3O6S	463.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	BEWX90	3-({(1S,2R)-1-[(S)-1-(4-Carbamimidoyl-benzylcarbamoyl)-3-methylsulfanyl-propylcarbamoyl]-2-hydroxy-propylsulfamoyl}-methyl)-benzoic acid	Investigative	44587292	C25H33N5O7S2	579.7	C[C@H]([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC1=CC=C(C=C1)C(=N)N)NS(=O)(=O)CC2=CC(=CC=C2)C(=O)O)O	Ki ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	BFC98M	3-(1H-Imidazo[4,5-c]pyridin-2-yl)-5-phenyl-1H-pyrazol-4-ol	Investigative	135988780	C15H11N5O	277.28	C1=CC=C(C=C1)C2=NNC(=C2O)C3=NC4=C(N3)C=NC=C4	Ki = 110000 nM	Poor binder
T83369	Coagulation factor IX	BFI01S	4-Cyano-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-2-fluorobenzamide	Investigative	118736115	C19H17FN4O	336.4	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=C(C=C(C=C3)C#N)F	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T83369	Coagulation factor IX	BJE9V8	2-Chloro-N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(triazol-1-yl)benzamide	Investigative	118736121	C20H19ClN6O	394.9	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=C(C=C(C=C3)N4C=CN=N4)Cl	Ki = 130000 nM	Poor binder
T83369	Coagulation factor IX	BK2SZ1	N-[2-(6-Carbamimidoyl-1H-benzimidazol-2-yl)ethyl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736111	C19H18N8O	374.4	C1=CC(=CC=C1C(=O)NCCC2=NC3=C(N2)C=C(C=C3)C(=N)N)N4C=NN=C4	Ki = 54200 nM	Poor binder
T83369	Coagulation factor IX	BNY76B	5-Chloro-N-(((3S,3aS)-1-oxo-7-(3-oxomorpholino)-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-3-yl)methyl)thiophene-2-carboxamide	Investigative	118713026	C21H20ClN3O5S	461.9	C1CC2=C(C=CC(=C2)N3CCOCC3=O)N4[C@@H]1[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	BQ5N3A	2-Chloro-N-[(2S)-1-(5,6-dimethyl-1H-benzimidazol-2-yl)propan-2-yl]-4-(1,2,4-triazol-4-yl)benzamide	Investigative	118736135	C21H21ClN6O	408.9	CC1=CC2=C(C=C1C)N=C(N2)C[C@H](C)NC(=O)C3=C(C=C(C=C3)N4C=NN=C4)Cl	Ki = 55400 nM	Poor binder
T83369	Coagulation factor IX	BRK61D	N-[2-(5,6-Dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(1,2,4-triazol-4-yl)benzamide	Investigative	118736114	C20H20N6O	360.4	CC1=CC2=C(C=C1C)N=C(N2)CCNC(=O)C3=CC(=CC=C3)N4C=NN=C4	Ki ~ 145000 nM	Poor binder
T83369	Coagulation factor IX	BT32CJ	4-[(N-{(2e)-3-[5-Chloro-2-(1h-Tetrazol-1-Yl)phenyl]prop-2-Enoyl}-L-Phenylalanyl)amino]benzoic Acid	Investigative	25166809	C26H21ClN6O4	516.9	C1=CC=C(C=C1)C[C@@H](C(=O)NC2=CC=C(C=C2)C(=O)O)NC(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4	Ki ~ 73000 nM	Poor binder
T83369	Coagulation factor IX	BVC8S1	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3,3a,4,5-tetrahydro-[1,3]oxazolo[3,4-a]quinoxalin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713029	C20H19ClN4O5S	462.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CN3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T83369	Coagulation factor IX	BWXE72	Chembl4227743	Investigative	88582319	C30H24Cl2N8O3	615.5	COC(=O)NC1=CC=C(C=C1)C2=CC(=NN=C2Cl)[C@H](CC3=CC=CC=C3)NC(=O)/C=C/C4=C(C=CC(=C4)Cl)N5C=NN=N5	Ki ~ 73700 nM	Poor binder