TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T85799	Cyclin-dependent kinase 4	D05ADP	R-roscovitine	Phase 2	160355	C19H26N6O	354.4	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	D00BPA	Olomoucine	Terminated	4592	C15H18N6O	298.34	CN1C=NC2=C(N=C(N=C21)NCCO)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	B34WHP	4,6 Bis anilino pyrimidine deriv. 9	Investigative	6539013	C22H27N5O3	409.5	CN(C)CC(COC1=CC=C(C=C1)NC2=NC=NC(=C2)NC3=CC=C(C=C3)OC)O	IC50 = 57000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	B3A9GH	(3r)-1-{2-[4-(4-Acetylphenyl)piperazin-1-Yl]-2-Oxoethyl}-N-(3-Chloro-4-Hydroxyphenyl)pyrrolidine-3-Carboxamide	Investigative	58985201	C25H29ClN4O4	485	CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C(=O)CN3CC[C@H](C3)C(=O)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 50000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	B5JCH6	[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[tert-butyl(2-hydroxyethyl)amino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetate	Investigative	24807809	C29H41NO9	547.6	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CCO)C(C)(C)C)/C4=C(C3=O)O)COC)C)C	IC50 ~ 50000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	B9QZ2W	1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea	Investigative	5328112	C18H18Cl2N6O	405.3	CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl	IC50 ~ 50000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	B9RCI4	2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one	Investigative	9869943	C25H27Cl2N5O	484.4	CCN(CC)C/C=C/C1=C(C2=C(C3=C(C=C2)N=C(N3C)NC4=C(C=CC=C4Cl)Cl)C(=O)N1)C	IC50 ~ 100000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	BP1B6K	Carbazole deriv. 22	Investigative	5330890	C22H16N2O	324.4	C1=CC(=CC(=C1)N)C2=CC=CC3=C2NC4=C3C5=C(C=CC(=C5)O)C=C4	IC50 = 74500 nM	Poor binder
T85799	Cyclin-dependent kinase 4	BRE4P2	(1E,4S,4Ar,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione	Investigative	11526786	C29H42N2O8	546.7	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(C)CCCN(C)C)/C4=C(C3=O)O)COC)C)C	IC50 ~ 50000 nM	Poor binder
T85799	Cyclin-dependent kinase 4	D0YZ7H	JNJ-10198409	Investigative	9797370	C18H16FN3O2	325.3	COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC	IC50 ~ 100000 nM	Poor binder