TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T86161	Prolyl endopeptidase	D02EYG	Linagliptin	Approved	10096344	C25H28N8O2	472.5	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	D0L3DK	Vildagliptin	Approved	6918537	C17H25N3O2	303.4	C1C[C@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	D0NJ5H	Alogliptin	Approved	11450633	C18H21N5O2	339.4	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	D0W8WB	Berberine	Phase 4	2353	C20H18NO4+	336.4	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC	IC50 = 145000 nM	Poor binder
T86161	Prolyl endopeptidase	D0M3XR	MK-3102	Phase 3	46209133	C17H20F2N4O3S	398.4	CS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 67000 nM	Poor binder
T86161	Prolyl endopeptidase	B0AY8M	(R)-3-Amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45101723	C21H18F5N5O2	467.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)C4=C(C=C(C=N4)F)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B0CQ9W	2-[(5-Cyanopyridin-2-yl)amino]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide	Investigative	73356495	C15H16N6O2	312.33	C1C[C@H](N(C1)C(=O)CNC(=O)CNC2=NC=C(C=C2)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B0EM4Z	(2S)-1-[(3Ar,4S,5R,7aS)-2-benzyl-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindole-4-carbonyl]pyrrolidine-2-carbonitrile	Investigative	127051278	C22H25N3O2	363.5	C[C@@H]1C=C[C@@H]2CN(C(=O)[C@H]2[C@H]1C(=O)N3CCC[C@H]3C#N)CC4=CC=CC=C4	Ki = 62000 nM	Poor binder
T86161	Prolyl endopeptidase	B0PNA9	(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester	Investigative	44381945	C19H27N3O4	361.4	COC1=CC=C(C=C1)NC(=O)O[C@H]2CC[C@@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B19JLV	(R)-3-Amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487940	C19H20F4N4O2	412.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NOC(=N3)C4(CC4)F	IC50 = 72000 nM	Poor binder
T86161	Prolyl endopeptidase	B1BC8W	N-[2-[(2S,4R)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	90655560	C17H15FN4O2	326.32	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B1JF8H	Benzyl N-[(3aS,4R,7aR)-4-cyano-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate	Investigative	127050075	C17H17N3O3	311.33	C1C=C[C@H]2CN(C(=O)[C@@H]2[C@@H]1C#N)NC(=O)OCC3=CC=CC=C3	Ki ~ 150000 nM	Poor binder
T86161	Prolyl endopeptidase	B1QB0E	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693954	C18H16N6O2	348.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B1T8CU	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamide	Investigative	90655558	C20H17FN6O2	392.4	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)N=C(N3)C4=CC=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B1W7KO	(2S)-1-(2-Benzamidoacetyl)-N-tert-butylpyrrolidine-2-carboxamide	Investigative	70689751	C18H25N3O3	331.4	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B2VIJ5	N-[2-[(2S)-2-Cyano-4-ethylpyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691905	C20H21N3O2	335.4	CCC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B2Y9VJ	1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	22029894	C21H24N6O2	392.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B36OVG	1-((S)-2-(Pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-2-((S)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone	Investigative	10449942	C21H28N2O2	340.5	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)C[C@H]3CCC4=CC=CC=C4C3	IC50 = 94000 nM	Poor binder
T86161	Prolyl endopeptidase	B37ATG	(R)-3-Amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45102670	C19H22F4N4O2	414.4	CC(C)(C1=NC(=NO1)[C@@H]2CCCN2C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B39BQF	(4-Methoxy-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester	Investigative	44382005	C20H29N3O4	375.5	COC1=CC=C(C=C1)NC(=O)O[C@@H]2CCC[C@@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B3DMN9	4-N-[(1R,3R)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]benzene-1,4-disulfonamide	Investigative	44381884	C17H26N4O5S2	430.5	C1CCN(C1)C(=O)[C@H]([C@@H]2CC[C@H](C2)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B3WXE4	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189877	C25H28N8O4	504.5	CC(=CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B48FPU	(S)-2-Amino-2-((1S,3S)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44382393	C11H20N2O2	212.29	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@@H](C2)O)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B48LRD	(3-Fluoro-phenyl)-carbamic acid (1R,3S)-3-((R)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclopentyl ester	Investigative	44381634	C17H22FN3O3S	367.4	C1C[C@H](C[C@H]1[C@H](C(=O)N2CCSC2)N)OC(=O)NC3=CC(=CC=C3)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B4AD9Y	1-[3-(Imidazole-1-carbonyl)-2-aza-bicyclo[2.2.2]oct-2-yl]-4-phenyl-butan-1-one	Investigative	10641689	C21H25N3O2	351.4	C1CC2CCC1C(N2C(=O)CCCC3=CC=CC=C3)C(=O)N4C=CN=C4	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B4ISG6	4-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentylsulfamoyl]-benzoic acid	Investigative	44381687	C18H25N3O5S	395.5	C1CCN(C1)C(=O)[C@H]([C@@H]2CC[C@H](C2)NS(=O)(=O)C3=CC=C(C=C3)C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B4RSC8	Benzyl N-[(3aS,4R,5S,7aR)-5-methyl-3-oxo-4-(pyrrolidine-1-carbonyl)-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate	Investigative	127050077	C22H27N3O4	397.5	C[C@H]1C=C[C@H]2CN(C(=O)[C@@H]2[C@@H]1C(=O)N3CCCC3)NC(=O)OCC4=CC=CC=C4	Ki = 67000 nM	Poor binder
T86161	Prolyl endopeptidase	B58LGR	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354470	C29H35F3N4O6	592.6	CC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B5D3TH	(R)-3-Amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487908	C20H24F3N5O2	423.4	C1CCN(C1)C2=NOC(=N2)[C@@H]3CCCN3C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B5JE4R	N-[2-[(2S)-2-Cyano-4-methylpyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70693955	C15H17N3O2	271.31	CC1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC=C2)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B5TW8V	(S)-2-Amino-2-((1S,3R)-3-methoxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44382006	C13H24N2O2	240.34	CO[C@@H]1CCC[C@@H](C1)[C@@H](C(=O)N2CCCC2)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B5XOQ9	N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide	Investigative	89705076	C18H18N4O3	338.4	C1C[C@H](N(C1)C(=O)[C@@H](CO)NC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B60QKI	4-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-4-oxobutanamide	Investigative	70685559	C28H31F2N5O3	523.6	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B67CVZ	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanamide	Investigative	70693952	C22H28FN5O3	429.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)N2CCN(CC2)CC3=CC=C(C=C3)F)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B6HGC1	(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile	Investigative	46917048	C20H20F2N4O3	402.4	C1[C@H](C(=O)N[C@@H]1C(=O)N2CC(C[C@H]2C#N)(F)F)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B6L7QG	CID 44123747	Investigative	44123747	C22H25FN6O2	424.5	C[C@]1(CCCN(C1)C2=CC3=C(N2CC4=C(C=CC(=C4)F)C#N)C(=O)N(C(=O)N3C)C)N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B6U5FD	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(5S)-3-oxo-5-(hydroxymethyl)piperazino]xanthine	Investigative	101887273	C25H26N8O4	502.5	CC#CCN1C2=C(N=C1N3C[C@H](NC(=O)C3)CO)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B6ZG7J	(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(5-(trifluoromethyl)pyridin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile	Investigative	44567710	C18H19F4N5O	397.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=NC=C(C=C4)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B70SUP	7-But-2-ynyl-3-methyl-1-[(5-methyl-2-phenyltriazol-4-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189870	C24H27N9O2	473.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NN(N=C4C)C5=CC=CC=C5)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B71MKZ	(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide	Investigative	71655554	C17H16N4O2	308.33	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N	IC50 = 83500 nM	Poor binder
T86161	Prolyl endopeptidase	B75EWK	7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione	Investigative	122189871	C23H25N9O2	459.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=NC=N5)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B7O6VW	7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione	Investigative	122189865	C22H22N6O3	418.4	CCOC1=NC2=C(N1CC#CC)C(=O)N(C(=O)N2C)CC3=NC4=CC=CC=C4C(=N3)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B7PLA6	N-[(1S,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide	Investigative	44381910	C18H27N3O5S2	429.6	CS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)N[C@H]2CC[C@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B7ZO4N	N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70691903	C14H14N6O2	298.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC=C2)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B87XAS	1,2,4,5-Tetrakis(phenylmethoxymethyl)-3,6-bis(4-phenylmethoxyphenyl)benzene	Investigative	118707567	C64H58O6	923.1	C1=CC=C(C=C1)COCC2=C(C(=C(C(=C2C3=CC=C(C=C3)OCC4=CC=CC=C4)COCC5=CC=CC=C5)COCC6=CC=CC=C6)C7=CC=C(C=C7)OCC8=CC=CC=C8)COCC9=CC=CC=C9	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B8A5VT	(3-Fluoro-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclopentyl ester	Investigative	44381635	C17H22FN3O3S	367.4	C1C[C@H](C[C@H]1[C@@H](C(=O)N2CCSC2)N)OC(=O)NC3=CC(=CC=C3)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B8H5AI	N-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethoxy-benzenesulfonamide	Investigative	44381911	C18H24F3N3O4S	435.5	C1CCN(C1)C(=O)[C@H]([C@@H]2CC[C@H](C2)NS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B8OMG4	N-[(1R,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethoxy-benzenesulfonamide	Investigative	44381633	C18H24F3N3O4S	435.5	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@H](C2)NS(=O)(=O)C3=CC=C(C=C3)OC(F)(F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B91XGN	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189875	C14H16N6O3	316.32	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B94LTU	(2S)-1-[2-[2-Methoxyethyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655545	C20H24N4O2	352.4	COCCN(CC1=CC=NC2=CC=CC=C12)CC(=O)N3CCC[C@H]3C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B9AE7Y	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354369	C31H39F3N4O6	620.7	CCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B9F4CL	[4-Acetyloxy-2,5-bis[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-3,6-bis(methoxymethyl)phenyl] acetate	Investigative	118707569	C38H54O8Si2	695	CC(=O)OC1=C(C(=C(C(=C1COC)C2=CC=C(C=C2)O[Si](C)(C)C(C)(C)C)OC(=O)C)COC)C3=CC=C(C=C3)O[Si](C)(C)C(C)(C)C	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	B9KAW6	US9346814, Ref. Cmpd No 4	Investigative	129010653	C16H16N4O2	296.32	C1CC(N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B9NS8E	(R)-3-Amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487903	C20H20F6N4O2	462.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)C4(CC4)C(F)(F)F	IC50 = 61000 nM	Poor binder
T86161	Prolyl endopeptidase	B9OZE8	3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	47370344	C11H14N6O3	278.27	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B9RQ3B	(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(thiazol-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile	Investigative	44568171	C15H18FN5OS	335.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=NC=CS4)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	B9XZ5N	N-[(3Ar,4S,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]-2-phenylacetamide	Investigative	127050945	C22H24N4O3	392.5	C1C[C@H](N(C1)C(=O)[C@H]2CC=C[C@H]3[C@H]2C(=O)N(C3)NC(=O)CC4=CC=CC=C4)C#N	Ki ~ 150000 nM	Poor binder
T86161	Prolyl endopeptidase	BA10GO	(2S)-1-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-methylamino]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655547	C15H21N5O2	303.36	CN(CC(=O)N1CCC[C@H]1C#N)CC(=O)N2CCC[C@H]2C#N	IC50 = 67000 nM	Poor binder
T86161	Prolyl endopeptidase	BA1G2W	4-N-[(1S,3R)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]benzene-1,4-disulfonamide	Investigative	44381919	C17H26N4O5S2	430.5	C1CCN(C1)C(=O)[C@H]([C@@H]2CC[C@@H](C2)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BA2QN3	N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]benzamide	Investigative	70689752	C15H17N3O2	271.31	C1CCN([C@@H](C1)C#N)C(=O)CNC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BA46MF	(R)-3-Amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487904	C20H24F3N5O3	439.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BA6RE2	2,6-Dichloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide	Investigative	70687705	C14H13Cl2N3O2	326.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C(C=CC=C2Cl)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BA93PR	N-[2-[(2S,4S)-2-Cyano-4-(trifluoromethyl)pyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691906	C19H16F3N3O2	375.3	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BAM13Q	(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(4-(trifluoromethyl)pyrimidin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile	Investigative	44568170	C17H18F4N6O	398.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=NC=CC(=N4)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BAV26G	1-(Quinoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887277	C24H25N7O2	443.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C=C4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BB16LV	US9346814, Ref Cmpd No 10	Investigative	78140064	C17H16N4O2	308.33	C1CC(N(C1)C(=O)CNC(=O)C2=CC=CC3=C2C=CN=C3)C#N	IC50 = 74100 nM	Poor binder
T86161	Prolyl endopeptidase	BB5G4J	Tert-butyl-[4-[4-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2,3,5,6-tetrakis(methoxymethyl)phenyl]phenoxy]-dimethylsilane	Investigative	118707566	C38H58O6Si2	667	CC(C)(C)[Si](C)(C)OC1=CC=C(C=C1)C2=C(C(=C(C(=C2COC)COC)C3=CC=C(C=C3)O[Si](C)(C)C(C)(C)C)COC)COC	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BB86PJ	6-((1S,5R,6s)-6-(2-((2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl)-2-oxoethylamino)-3-aza-bicyclo[3.1.0]hexan-3-yl)nicotinonitrile	Investigative	44567711	C18H19FN6O	354.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=NC=C(C=C4)C#N)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BB9AT8	7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189864	C19H23N7O3S	429.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CSC(=N4)CO)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BBU16R	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine	Investigative	101887274	C24H26N8O3	474.5	CC#CCN1C2=C(N=C1NCCNC(=O)C)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BC3O6M	2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile	Investigative	122189869	C28H27N7O2	493.6	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)C5=CC=CC=C5C#N)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BC71PG	(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl ester	Investigative	44381721	C19H27N3O4S	393.5	COC1=CC=C(C=C1)NC(=O)O[C@H]2CCC[C@@H](C2)[C@@H](C(=O)N3CCSC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BCE3S8	7-But-2-ynyl-3-methyl-1-(naphthalen-2-ylmethyl)-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189868	C25H26N6O2	442.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC5=CC=CC=C5C=C4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BCP13I	N-[3-[(3-Acetamidophenoxy)-[1-(pyrrolidine-2-carbonyl)pyrrolidin-2-yl]phosphoryl]oxyphenyl]acetamide;hydrochloride	Investigative	49795929	C25H32ClN4O6P	551	CC(=O)NC1=CC(=CC=C1)OP(=O)(C2CCCN2C(=O)C3CCCN3)OC4=CC=CC(=C4)NC(=O)C.Cl	IC50 = 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BCSR15	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-2-carboxamide	Investigative	73350448	C16H16N4O2	296.32	C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC3=CC=CC=C3N2)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BCU72K	1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887271	C24H26N8O3	474.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BCY75P	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide	Investigative	89712515	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NNN=C2)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BD7Z9M	N-[2-[(2S)-2-Cyano-4-methylidenepyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70683455	C19H17N3O2	319.4	C=C1C[C@H](N(C1)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BDTL57	5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide	Investigative	71655623	C17H15BrN4O2	387.2	C1C[C@H](N(C1)C(=O)CNC(=O)C2=C3C(=NC=C2)C=CC=C3Br)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BDXS01	(R)-3-Amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487894	C20H23F3N4O2	408.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)CC4CC4	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BE6K7V	(2S)-1-[(3Ar,4S,7aS)-3-oxo-2-phenylmethoxy-3a,4,5,7a-tetrahydro-1H-isoindole-4-carbonyl]pyrrolidine-2-carbonitrile	Investigative	127051276	C21H23N3O3	365.4	C1C[C@H](N(C1)C(=O)[C@H]2CC=C[C@H]3[C@H]2C(=O)N(C3)OCC4=CC=CC=C4)C#N	Ki ~ 150000 nM	Poor binder
T86161	Prolyl endopeptidase	BE6UQ3	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine	Investigative	101887276	C28H27N9O3	537.6	CC#CCN1C2=C(N=C1NCCNC(=O)C3=CC=NC=C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BET9R0	Benzyl N-[(3aR,4S,5R,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate	Investigative	127050315	C23H26N4O4	422.5	C[C@@H]1C=C[C@@H]2CN(C(=O)[C@H]2[C@H]1C(=O)N3CCC[C@H]3C#N)NC(=O)OCC4=CC=CC=C4	Ki ~ 150000 nM	Poor binder
T86161	Prolyl endopeptidase	BF1OX0	Methyl 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oate	Investigative	44575408	C33H52O5	528.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@H]([C@]([C@@H]5CC[C@]4([C@@]3(CC2)CO)C)(C)C(=O)OC)OC(=O)C)C)C	IC50 = 57430 nM	Poor binder
T86161	Prolyl endopeptidase	BF5C8N	8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione	Investigative	122189874	C18H26N6O2	358.4	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BF5N2S	(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796938	C27H38F3N3O7	573.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C(C3CCCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BG1L0U	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(6S)-1,4-diazabicyclo[4.3.0]nonane-4-yl]xanthine	Investigative	101887278	C27H30N8O2	498.6	CC#CCN1C2=C(N=C1N3CCN4CCC[C@H]4C3)N(C(=O)N(C2=O)CC5=NC6=CC=CC=C6C(=N5)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BGPL85	2-Methanesulfonylamino-ethanesulfonic acid [(1R,3R)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-amide	Investigative	10046311	C14H28N4O5S2	396.5	CS(=O)(=O)NCCS(=O)(=O)N[C@@H]1CC[C@H](C1)[C@@H](C(=O)N2CCCC2)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BGT19Y	(2S)-1-(2-Naphthalen-2-yloxyacetyl)pyrrolidine-2-carbonitrile	Investigative	73345857	C17H16N2O2	280.32	C1C[C@H](N(C1)C(=O)COC2=CC3=CC=CC=C3C=C2)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BGVF71	N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethanesulfonyl-benzenesulfonamide	Investigative	44381861	C18H24F3N3O5S2	483.5	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@@H](C2)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)C(F)(F)F)N	IC50 = 77000 nM	Poor binder
T86161	Prolyl endopeptidase	BH4AD7	N'-[Bis(4-fluorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]butanediamide	Investigative	70687706	C24H24F2N4O3	454.5	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BH50KZ	(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride	Investigative	23628283	C21H23ClF3N3O2	441.9	C1CCN(N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(=O)C3=CC=CC=C3.Cl	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BH6Z3P	(4-Iodo-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester	Investigative	44381974	C19H26IN3O3	471.3	C1CCN(C1)C(=O)[C@H]([C@H]2CCC[C@@H](C2)OC(=O)NC3=CC=C(C=C3)I)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BHW27S	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione	Investigative	122189872	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CN=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BHXZ75	7-Benzyl-1-[(4-methoxyquinazolin-2-yl)methyl]-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189879	C27H26N8O4	526.5	CN1C2=C(C(=O)N(C1=O)CC3=NC4=CC=CC=C4C(=N3)OC)N(C(=N2)N5CCNC(=O)C5)CC6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BI4BM3	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-[4-(3,4-difluorophenyl)triazol-1-yl]acetamide	Investigative	70693953	C17H16F2N6O2	374.3	C1C[C@H](N(C1)C(=O)CNC(=O)CN2C=C(N=N2)C3=CC(=C(C=C3)F)F)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BI9O1C	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887269	C24H24N8O3	472.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BIG1T8	N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide	Investigative	71655556	C18H18N4O3	338.4	CC1=NC2=CC=CC=C2C(=C1O)C(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 = 53600 nM	Poor binder
T86161	Prolyl endopeptidase	BJ3U5P	(R)-1-((S)-2-(3-(1-Acetylazetidin-3-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487931	C21H24F3N5O3	451.4	CC(=O)N1CC(C1)C2=NOC(=N2)[C@@H]3CCCN3C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 = 65000 nM	Poor binder
T86161	Prolyl endopeptidase	BJ4X3T	1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	11374531	C24H26N8O2	458.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BJM05V	N-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide	Investigative	9823963	C18H27N3O5S2	429.6	CS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)N[C@@H]2CC[C@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BK0RJ1	N-[(1R,3S)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]naphthalene-1-carboxamide	Investigative	44381846	C22H27N3O2	365.5	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@H](C2)NC(=O)C3=CC=CC4=CC=CC=C43)N	IC50 = 59000 nM	Poor binder
T86161	Prolyl endopeptidase	BK2PF3	1-((S)-2-(Pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-2-((R)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone	Investigative	10088633	C21H28N2O2	340.5	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)C[C@@H]3CCC4=CC=CC=C4C3	IC50 = 91000 nM	Poor binder
T86161	Prolyl endopeptidase	BKA5O2	N'-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-[(4-fluorophenyl)methyl]butanediamide	Investigative	70691902	C18H21FN4O3	360.4	C1C[C@H](N(C1)C(=O)CNC(=O)CCC(=O)NCC2=CC=C(C=C2)F)C#N	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BKHN60	(4-Methoxy-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl ester	Investigative	44382521	C19H27N3O4S	393.5	COC1=CC=C(C=C1)NC(=O)O[C@@H]2CCC[C@@H](C2)[C@@H](C(=O)N3CCSC3)N	IC50 = 76000 nM	Poor binder
T86161	Prolyl endopeptidase	BL4AW0	(R)-3-Amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487915	C19H21F3N4O2	394.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NOC(=N3)C4CC4	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BL82NA	1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189876	C21H22N8O4	450.5	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BLA28H	2-Indan-2-yl-1-[(S)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-ethanone	Investigative	10449078	C20H26N2O2	326.4	C1CCN(C1)C(=O)[C@@H]2CCCN2C(=O)CC3CC4=CC=CC=C4C3	IC50 = 80000 nM	Poor binder
T86161	Prolyl endopeptidase	BLW9G8	(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid	Investigative	53354365	C30H37F3N4O6	606.6	CCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)NC(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)N[C@@H](CCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BLXQ31	Unii-Z82X63Q1Z5	Investigative	122189866	C27H30N8O3	514.6	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)NC(=O)C)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BM6YD5	[(2R)-1-[(2R)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid	Investigative	9942554	C9H19BN2O3	214.07	B([C@@H]1CCCN1C(=O)[C@@H](C(C)C)N)(O)O	IC50 = 61000 nM	Poor binder
T86161	Prolyl endopeptidase	BMP7F1	N-[(1S,3S)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]-2-(methanesulfonamido)ethanesulfonamide	Investigative	44381645	C14H28N4O5S2	396.5	CS(=O)(=O)NCCS(=O)(=O)N[C@H]1CC[C@@H](C1)[C@@H](C(=O)N2CCCC2)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BMX32J	3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile	Investigative	22029457	C22H23N7O2	417.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC(=CC=C4)C#N)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BN4IJ3	Ethyl 5-methyl-4-naphthalen-1-yl-2,3-dihydrofuro[3,2-c]quinolin-5-ium-8-carboxylate;iodide	Investigative	90666507	C25H22INO3	511.3	CCOC(=O)C1=CC2=C(C=C1)[N+](=C(C3=C2OCC3)C4=CC=CC5=CC=CC=C54)C.[I-]	IC50 = 75000 nM	Poor binder
T86161	Prolyl endopeptidase	BN9WM6	2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide	Investigative	122189867	C22H22N8O3	446.5	CC#CCN1C2=C(N=C1NCC(=O)N)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BNMG86	Ethyl 4-(4-chlorophenyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium-8-carboxylate;iodide	Investigative	46889276	C21H19ClINO3	495.7	CCOC(=O)C1=CC2=C(C=C1)[N+](=C(C3=C2OCC3)C4=CC=C(C=C4)Cl)C.[I-]	IC50 = 65000 nM	Poor binder
T86161	Prolyl endopeptidase	BO4R1X	US9346814, Cmpd No 37 Example 42	Investigative	89704955	C10H12N6O2	248.24	C1C[C@H](N(C1)C(=O)CNC(=O)C2=NC=NN2)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BO61MP	1-(Quinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887270	C23H24N8O2	444.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C=N4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BOB3V8	Benzyl N-[(3aS,4R,5S,7aR)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate	Investigative	127050631	C23H26N4O4	422.5	C[C@H]1C=C[C@H]2CN(C(=O)[C@@H]2[C@@H]1C(=O)N3CCC[C@H]3C#N)NC(=O)OCC4=CC=CC=C4	Ki = 62500 nM	Poor binder
T86161	Prolyl endopeptidase	BOF67R	(S)-2-Amino-2-((1S,3R)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44381811	C11H20N2O2	212.29	C1CCN(C1)C(=O)[C@H]([C@H]2CC[C@H](C2)O)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BP65UJ	(2S)-1-[2-(4-Phenyltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile	Investigative	90655548	C15H15N5O	281.31	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BP9RX3	(2S,4S)-1-(2-((1S,5R,6s)-3-(Benzo[d]oxazol-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)-4-fluoropyrrolidine-2-carbonitrile	Investigative	44567652	C19H20FN5O2	369.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=NC5=CC=CC=C5O4)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BPW15G	Benzyl N-[(3aR,4S,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate	Investigative	127050024	C22H24N4O4	408.4	C1C[C@H](N(C1)C(=O)[C@H]2CC=C[C@H]3[C@H]2C(=O)N(C3)NC(=O)OCC4=CC=CC=C4)C#N	Ki = 80000 nM	Poor binder
T86161	Prolyl endopeptidase	BQ3DE2	Tert-butyl 4-[1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]triazol-4-yl]piperazine-1-carboxylate	Investigative	70685560	C20H30N8O4	446.5	CC(C)(C)OC(=O)N1CCN(CC1)C2=CN(N=N2)CC(=O)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BQ57KW	(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester	Investigative	44381763	C20H29N3O4	375.5	COC1=CC=C(C=C1)NC(=O)O[C@H]2CCC[C@@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BQ8H2C	[(2R)-1-[(2R)-2-(Pyridine-3-carbonylamino)propanoyl]pyrrolidin-2-yl]boronic acid	Investigative	71655268	C13H18BN3O4	291.11	B([C@@H]1CCCN1C(=O)[C@@H](C)NC(=O)C2=CN=CC=C2)(O)O	IC50 = 91000 nM	Poor binder
T86161	Prolyl endopeptidase	BQK20C	(R)-3-Amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487922	C20H25F3N4O2	410.4	CC(C)(C)C1=NC(=NO1)[C@@H]2CCCN2C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BQYB16	(2S)-1-[2-[4-(4-Fluorophenyl)triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655549	C15H14FN5O	299.3	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)C3=CC=C(C=C3)F)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BR9NL3	N-(2-Oxo-2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide	Investigative	90655561	C16H17N3O2	283.32	C1CCN(C1)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23	IC50 ~ 50000 nM	Poor binder
T86161	Prolyl endopeptidase	BRP1K4	Ethyl 4-((1S,5R,6s)-6-(2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethylamino)-3-aza-bicyclo[3.1.0]hexan-3-yl)benzoate	Investigative	44568017	C21H25FN4O3	400.4	CCOC(=O)C1=CC=C(C=C1)N2C[C@@H]3[C@H](C2)C3NCC(=O)N4C[C@H](C[C@H]4C#N)F	IC50 = 62200 nM	Poor binder
T86161	Prolyl endopeptidase	BRXF01	1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887279	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=CC=N4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BSD91R	N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-2-methanesulfonyl-benzenesulfonamide	Investigative	44382065	C18H27N3O5S2	429.6	CS(=O)(=O)C1=CC=CC=C1S(=O)(=O)N[C@H]2CC[C@@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BSV86X	N-[2-[(2S,4R)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70691904	C18H16N6O2	348.4	C1[C@H](CN([C@@H]1C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32)N=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BT04CA	1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887275	C24H26N8O2	458.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=CC=N5)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BT0FV5	(S)-2-Amino-2-((1S,3S)-3-hydroxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone	Investigative	44382443	C12H22N2O2	226.32	C1CCN(C1)C(=O)[C@H]([C@H]2CCC[C@@H](C2)O)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BT5Y2N	(2S)-1-[2-[4-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile	Investigative	90655550	C20H22N6O2	378.4	C1C[C@H](N(C1)C(=O)CN2C=C(N=N2)CCC(=O)N3CC4=CC=CC=C4C3)C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BTQA72	(3R,4R,4Ar,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-methyl 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylate	Investigative	11799085	C31H48O4	484.7	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC(=O)[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@H]([C@]5(C)C(=O)OC)O)C)C)[C@@H]2[C@H]1C)C)C	IC50 = 114750 nM	Poor binder
T86161	Prolyl endopeptidase	BU6N9T	(4-Iodo-phenyl)-carbamic acid (1S,3R)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester	Investigative	44381967	C18H24IN3O3	457.3	C1CCN(C1)C(=O)[C@H]([C@@H]2CC[C@@H](C2)OC(=O)NC3=CC=C(C=C3)I)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BU75NX	CID 89704940	Investigative	89704940	C21H20N6O3	404.4	COC1=CC=C(C=C1)C2=NC3=NC=CC(=C3N2)C(=O)NCC(=O)N4CCC[C@H]4C#N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BUTA21	1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine	Investigative	101887272	C24H24N8O4	488.5	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BV7Q2F	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796955	C29H31F8N3O7	685.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C(=C(C(=C3F)F)F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BV8IR6	(R)-3-Amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487917	C20H23F3N4O3	424.4	CC1(COC1)C2=NC(=NO2)[C@@H]3CCCN3C(=O)C[C@@H](CC4=CC(=C(C=C4F)F)F)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BVOK43	(R)-3-Amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487930	C19H21F3N4O2	394.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)C4CC4	IC50 = 57000 nM	Poor binder
T86161	Prolyl endopeptidase	BVQ4D9	N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide	Investigative	44381862	C18H27N3O5S2	429.6	CS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)N[C@H]2CC[C@@H](C2)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BWZC31	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione	Investigative	122189873	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=NC=C4)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BX4WD0	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189878	C26H30N8O4	518.6	CC(=CCCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BXIF36	(2S,4S)-1-(2-((1S,5R,6s)-3-(2-Cyano-4-(trifluoromethyl)phenyl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)-4-fluoropyrrolidine-2-carbonitrile	Investigative	44568100	C20H19F4N5O	421.4	C1[C@@H](CN([C@@H]1C#N)C(=O)CNC2[C@H]3[C@@H]2CN(C3)C4=C(C=C(C=C4)C(F)(F)F)C#N)F	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BYH49E	N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide	Investigative	70693956	C19H19N3O2	321.4	C1CCN([C@@H](C1)C#N)C(=O)CNC(=O)C2=CC=CC3=CC=CC=C32	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BYT61V	Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid	Investigative	49796933	C26H29F4N3O6S	587.6	COC(=O)CC1=CC=C(C=C1)CNC(=O)[C@@H]2CSCN2C(=O)CC(CC3=CC=CC=C3F)N.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BZCO34	N-[(3As,4R,7aR)-3-oxo-4-(pyrrolidine-1-carbonyl)-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]-2-phenylacetamide	Investigative	127050078	C21H25N3O3	367.4	C1CCN(C1)C(=O)[C@@H]2CC=C[C@@H]3[C@@H]2C(=O)N(C3)NC(=O)CC4=CC=CC=C4	Ki = 65000 nM	Poor binder
T86161	Prolyl endopeptidase	BZI1R7	7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione	Investigative	89668929	C25H27N7O2	457.5	CC#CCN1C2=C(N=C1N3CCCCC3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C	IC50 ~ 100000 nM	Poor binder
T86161	Prolyl endopeptidase	BZUF36	(R)-3-Amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one	Investigative	45487946	C20H19F3N6O2	432.4	C1C[C@H](N(C1)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)C3=NC(=NO3)C4=NC=CN=C4	IC50 ~ 100000 nM	Poor binder