TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T87675	Aurora kinase A	D0J9ZR	Niclosamide	Approved	4477	C13H8Cl2N2O4	327.12	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O	IC50 = 54100 nM	Poor binder
T87675	Aurora kinase A	D0Y9ZE	Milrinone	Approved	4197	C12H9N3O	211.22	CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	D0U4EU	SB-743921	Phase 2	11261882	C30H32BrClN4O2	596	CCC(C1=NC2=C(C=CC(=C2)Cl)C(=O)N1CC3=CC=CC=C3)N(CCCN(C)C)C(=O)C4=CC=C(C=C4)Br	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B0QDX7	6-n-Hexylaminopurine	Investigative	1870	C11H17N5	219.29	CCCCCCNC1=NC=NC2=C1NC=N2	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B0UX8Y	N-(2-Methoxyphenyl)-2-(3-methylimidazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76324874	C18H17N5O	319.4	CN1C=NC=C1C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 = 72000 nM	Poor binder
T87675	Aurora kinase A	B1QHW6	Methyl 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinate	Investigative	135620676	C20H17N5O3	375.4	COC1=CC2=C(C=C1)N=C(N2)C3=C(C=NN3)/C=C/C4=CC(=CN=C4)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B1XKE7	CID 71578744	Investigative	71578744	C17H13N5O2S	351.4	CC(=O)NC1=NC=CC(=C1)C2=NN=C(O2)SCC3=CC(=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B1Y0ES	4-(3,4-Dimethoxyphenyl)-N-(2,4-dimethylphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxamide	Investigative	22426194	C29H26N4O3	478.5	CC1=CC(=C(C=C1)NC(=O)C2=CC(=NC3=NNC(=C23)C4=CC=CC=C4)C5=CC(=C(C=C5)OC)OC)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B24BFS	2-(2-Aminopyridin-4-yl)-5-(4-ethylphenyl)imino-6-methyl-4-thia-6-azaspiro[2.4]heptan-7-one	Investigative	134143552	C19H20N4OS	352.5	CCC1=CC=C(C=C1)N=C2N(C(=O)C3(S2)CC3C4=CC(=NC=C4)N)C	IC50 = 76000 nM	Poor binder
T87675	Aurora kinase A	B2M5XC	CID 68291184	Investigative	68291184	C25H28ClN7O	478	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N5CCC(CC5)N(C)C)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B2TDR1	2-(1,3-Benzodioxol-5-yl)-5-[[4-(3,5-difluorophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71578446	C22H14F2N2O3S	424.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC(=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B30DQK	7-Iodoindirubin-3-acetoxime	Investigative	136104464	C18H12IN3O3	445.2	CC(=O)O/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B35CDQ	7-Chloroindirubin-3-acetoxime	Investigative	136104462	C18H12ClN3O3	353.8	CC(=O)O/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B3HWU9	2-Methoxy-5-(pyridine-4-yl)pyridine-3-amine	Investigative	13942472	C11H11N3O	201.22	COC1=C(C=C(C=N1)C2=CC=NC=C2)N	Ki = 184700 nM	Poor binder
T87675	Aurora kinase A	B3KPB9	7-Bromoindirubin	Investigative	135423783	C16H9BrN2O2	341.16	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4Br)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B3M7JY	1-(1H-Benzimidazol-2-yl)-N-methyl-2-oxo-3H-benzimidazole-5-carboxamide	Investigative	134135714	C16H13N5O2	307.31	CNC(=O)C1=CC2=C(C=C1)N(C(=O)N2)C3=NC4=CC=CC=C4N3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B3V9PA	2-[[4-(4-Methoxyphenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole	Investigative	71212403	C21H17N3O2S	375.4	COC1=CC=C(C=C1)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B3Z2PX	7-Iodoindirubin-3-methoxime	Investigative	136104469	C17H12IN3O2	417.2	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4FHT8	2-[[4-(3,5-Difluorophenyl)phenyl]methylsulfanyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole	Investigative	71212517	C23H16F2N2O3S	438.4	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC(=CC(=C5)F)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4HU5D	Cyclapolin 9	Investigative	2779952	C9H4F3N3O4S	307.21	C1=C(C=C(C2=C1[N+](=C(S2)C(=O)N)[O-])[N+](=O)[O-])C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4JC3D	N-(2,4-Dimethoxyphenyl)-2-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76335739	C20H18F3N5O2	417.4	CN1C=C(C(=N1)C(F)(F)F)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)OC)OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4JU8K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide	Investigative	25271513	C21H22ClN5O3	427.9	COCCNC(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4NZ6S	3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide	Investigative	46934144	C24H20ClN3O3	433.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4WX0K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide	Investigative	25271517	C24H20ClN5O2	445.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)NC4=CC=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B4ZNV6	5-Amino-[3,3'-bipyridin]-6(1H)-one	Investigative	119131	C10H9N3O	187.2	C1=CC(=CN=C1)C2=CNC(=O)C(=C2)N	Ki = 125200 nM	Poor binder
T87675	Aurora kinase A	B54IZK	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide	Investigative	25271514	C25H29ClN6O2	481	C1CCN(CC1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 = 100000 nM	Poor binder
T87675	Aurora kinase A	B57DPR	CID 66548650	Investigative	66548650	C19H16F3N5O	387.4	COC1=CC=CC=C1NC2=NC=C3C=C(NC3=C2)C4=CN(N=C4)CC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B5A1WV	Tert-butyl 6-(2-chloro-4-pyrimidin-5-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	76335738	C26H24ClN7O2	502	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=CN=CN=C4)Cl)C5=CN(N=C5)C	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B5AST9	N-[4-[5-[[4-(2-Cyanophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide	Investigative	71578745	C23H17N5O2S	427.5	CC(=O)NC1=NC=CC(=C1)C2=NN=C(O2)SCC3=CC=C(C=C3)C4=CC=CC=C4C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B5YNV2	6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	Investigative	53357328	C27H27N3O2	425.5	CC1(C2=C(C=CC(=C2)C3CCN(CC3)C4COC4)C(=O)C5=C1NC6=C5C=CC(=C6)C#N)C	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B61HPW	3-Methoxy-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide	Investigative	68290592	C21H22N6O2	390.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N(C)C)OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B65WVG	N-(2-Methoxyphenyl)-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine	Investigative	68290919	C18H17N5O	319.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B6IY1P	2-(3,5-Dimethyl-1,2-oxazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76328435	C19H18N4O2	334.4	CC1=C(C(=NO1)C)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B6J8GD	3-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile	Investigative	71212514	C21H14N4OS	370.4	C1=CC(=CC(=C1)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC=NC=C4)C#N	IC50 = 60000 nM	Poor binder
T87675	Aurora kinase A	B6UO1Y	2-[(3S,6R,11R,14S,17S,23S,26S)-6-Amino-11-[(2-amino-2-oxoethyl)carbamoyl]-23-(3-amino-3-oxopropyl)-14-[(1R)-1-hydroxyethyl]-3-(1H-imidazol-5-ylmethyl)-2,5,13,16,19,22,25-heptaoxo-8,9-dithia-1,4,12,15,18,21,24-heptazabicyclo[24.3.0]nonacosan-17-yl]acetic acid	Investigative	57399871	C34H51N13O13S2	914	C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N1)CC(=O)O)CCC(=O)N)CC3=CN=CN3)N)C(=O)NCC(=O)N)O	IC50 = 137000 nM	Poor binder
T87675	Aurora kinase A	B71WTS	Tert-butyl 6-(2-chloroanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	68291366	C22H22ClN5O2	423.9	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=CC=CC=C3Cl)C4=CN(N=C4)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B79YJF	2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole	Investigative	24370907	C20H15N3OS	345.4	C1=CC=C(C=C1)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B7B4UD	N-[2-Chloro-4-(1-methylpyrazol-4-yl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76310311	C21H18ClN7	403.9	CN1C=C(C=N1)C2=CC(=C(C=C2)NC3=NC=C4C=C(NC4=C3)C5=CN(N=C5)C)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B7KX8L	N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine	Investigative	25063262	C25H26ClN7O3	508	C1COCCN1CCC2=NN=C(O2)C3=C(N=CN=C3NC4=CC(=C(C=C4)OCC5=CC=CC=C5)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B7OY1C	2-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile	Investigative	30291292	C21H14N4OS	370.4	C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B7VUJ2	TC-Mps1-12	Investigative	70682875	C17H20N6O	324.4	CC(C)(C)NC1=C(C(=CC(=N1)NC2=CC=C(C=C2)C(=O)N)N)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B7ZDB8	(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232443	C17H12Cl2FNO	336.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B8CA1J	7-Bromoindirubin-3-methoxime	Investigative	136104468	C17H12BrN3O2	370.2	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Br)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B8F0PB	[3,4'-Bipyridin]-6(1H)-one, 5-amino-2-methyl-	Investigative	12799333	C11H11N3O	201.22	CC1=C(C=C(C(=O)N1)N)C2=CC=NC=C2	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	B8YTQ3	CID 49806721	Investigative	49806721	C28H30N4O2	454.6	CCC1=CC2=C(C=C1N3CCN(CC3)C4COC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B96QXM	Tert-butyl 6-[2-chloro-4-(4-methoxypiperidine-1-carbonyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	68310582	C29H33ClN6O4	565.1	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C(=O)N4CCC(CC4)OC)Cl)C5=CN(N=C5)C	IC50 = 65000 nM	Poor binder
T87675	Aurora kinase A	B9DY1O	N-(4-Chlorophenyl)-3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzamide	Investigative	124081228	C24H17ClF3N5O	483.9	C1=CC(=CC(=C1)NC2=NC=CC(=N2)NC3=CC=CC(=C3)C(F)(F)F)C(=O)NC4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	B9HKQ6	N-[4-(5-Benzylsulfanyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]acetamide	Investigative	71578658	C16H14N4O2S	326.4	CC(=O)NC1=NC=CC(=C1)C2=NN=C(O2)SCC3=CC=CC=C3	IC50 = 60000 nM	Poor binder
T87675	Aurora kinase A	B9MNA5	Bisanilinopyrimidine, 3k	Investigative	70702126	C19H16N4O4	364.4	CC1=CC(=NC(=N1)NC2=CC=C(C=C2)C(=O)O)NC3=CC=CC=C3C(=O)O	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BA2M7D	N-(6-Oxo-1,6-dihydro-[3,4']bipyridinyl-5-yl)-benzenesulfonamide	Investigative	58692572	C16H13N3O3S	327.4	C1=CC=C(C=C1)S(=O)(=O)NC2=CC(=CNC2=O)C3=CC=NC=C3	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BAJD06	Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate	Investigative	16666757	C18H20N2O3	312.4	CC(C)(C)OC(=O)N1C=CC=C1C2=CC=CC3=C2C(=O)N(C3)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BALM86	3-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-one	Investigative	134136561	C15H9F3N4O	318.25	C1=CC=C2C(=C1)NC(=O)N2C3=NC4=C(N3)C=C(C=C4)C(F)(F)F	IC50 ~ 70000 nM	Poor binder
T87675	Aurora kinase A	BB05SD	7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one	Investigative	135423792	C16H10BrN3O2	356.17	C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O	IC50 = 100000 nM	Poor binder
T87675	Aurora kinase A	BBAP96	N-(2-Cyclohexenylethyl)-2-(4-(6-methoxy-1H-indole-2-carbonyl)cyclohexyl)propanamide	Investigative	53325994	C27H36N2O3	436.6	CC(C1CCC(CC1)C(=O)C2=CC3=C(N2)C=C(C=C3)OC)C(=O)NCCC4=CCCCC4	IC50 = 86150 nM	Poor binder
T87675	Aurora kinase A	BBLR71	2-[(3S,9S,12R,17R,20S,23S,26S)-12-Amino-17-[(2-amino-2-oxoethyl)carbamoyl]-20,23-bis[3-(diaminomethylideneamino)propyl]-3-[(1R)-1-hydroxyethyl]-2,5,8,11,19,22,25-heptaoxo-14,15-dithia-1,4,7,10,18,21,24-heptazabicyclo[24.3.0]nonacosan-9-yl]acetic acid	Investigative	57394672	C35H60N16O12S2	961.1	C[C@H]([C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CC(=O)O)N)C(=O)NCC(=O)N)CCCN=C(N)N)CCCN=C(N)N)O	IC50 = 91000 nM	Poor binder
T87675	Aurora kinase A	BBYX32	N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine	Investigative	56835161	C31H27ClF2N4O	545	CC1=C(C(=NC=N1)NC2=CC(=C(C=C2)OCC3=CC(=CC=C3)F)Cl)C#CC4=CC(=C(C=C4)CN5CCCC5)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BC5PG1	N-(4-Ethoxyphenyl)-2-(8-(4-ethoxyphenylamino)-3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide	Investigative	1164022	C24H26N6O5	478.5	CCOC1=CC=C(C=C1)NC2=NC3=C(N2CC(=O)NC4=CC=C(C=C4)OCC)C(=O)NC(=O)N3C	IC50 = 98700 nM	Poor binder
T87675	Aurora kinase A	BCRO12	2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71578307	C23H17N3O5S	447.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BCY2T5	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide	Investigative	25271515	C24H27ClN6O3	483	C1COCCN1CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BD26EW	3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate	Investigative	25271180	C25H20ClFN4O3	478.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)OCC4=CC(=CC=C4)F)N)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BD4PK3	(5Z)-2-(2-Ethylphenyl)imino-3-methyl-5-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one	Investigative	134138729	C18H17N3OS	323.4	CCC1=CC=CC=C1N=C2N(C(=O)/C(=C/C3=CC=NC=C3)/S2)C	IC50 = 52000 nM	Poor binder
T87675	Aurora kinase A	BD7Q2A	3-[3-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]butanamide	Investigative	124081227	C21H20F3N5O	415.4	CC(CC(=O)N)C1=CC(=CC=C1)NC2=NC=CC(=N2)NC3=CC=CC(=C3)C(F)(F)F	IC50 ~ 150000 nM	Poor binder
T87675	Aurora kinase A	BDXS86	2-({2-[(4-Carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acid	Investigative	698343	C18H14N4O4	350.3	C1=CC=C(C(=C1)C(=O)O)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BE45ZP	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide	Investigative	44562431	C25H28ClN7O4	526	C1COCCN1CCC(=O)NNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BE46DN	7-Fluoroindirubin-3-methoxime	Investigative	136104467	C17H12FN3O2	309.29	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4F)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BE94HA	2-[3-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropane-1-carboxamide	Investigative	124081224	C21H18F3N5O	413.4	C1C(C1C(=O)N)C2=CC(=CC=C2)NC3=NC=CC(=N3)NC4=CC=CC(=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BEN45S	6-[2-Chloro-4-(1-methyl-1H-pyrazole-4-yl)anilino]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester	Investigative	76313983	C26H26ClN7O2	504	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=CN(N=C4)C)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BEQ7V4	2-(1,5-Dimethylpyrazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76313985	C19H19N5O	333.4	CC1=C(C=NN1C)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BG13NL	2-[[2-Anilino-6-(dimethylamino)pyrimidin-4-yl]amino]benzoic acid	Investigative	71472625	C19H19N5O2	349.4	CN(C)C1=NC(=NC(=C1)NC2=CC=CC=C2C(=O)O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BG1T9K	4-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile	Investigative	71212434	C21H14N4OS	370.4	C1=CC(=CC=C1CSC2=NN=C(O2)C3=CC=NC=C3)C4=CC=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BG5LM7	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide	Investigative	25271181	C22H24ClN5O2	425.9	CCN(CC)C(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BG5SC2	Chembl4280041	Investigative	145980334	C14H17N3O	243.3	CN(C)CC1=CC=C(C=C1)C2=CNC(=O)C(=C2)N	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BGN94P	7-Chloroindirubin	Investigative	135423851	C16H9ClN2O2	296.71	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BGR0S1	3-Oxoisoindoline-4-carboxylic acid	Investigative	44579994	C9H7NO3	177.16	C1C2=C(C(=CC=C2)C(=O)O)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BGVU25	N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide	Investigative	16723801	C23H20ClN3O	389.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BHI65O	3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzenesulfonamide	Investigative	68291099	C19H19ClN6O2S	430.9	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)S(=O)(=O)N(C)C)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BHTK41	2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile	Investigative	71212446	C25H19N3O4S	457.5	COC1=CC(=C(C=C1)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC5=C(C=C4)OCCO5)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BIDW28	Tert-butyl 6-(2-chloro-4-pyrazin-2-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	76335737	C26H24ClN7O2	502	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=NC=CN=C4)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BIO5X9	2-(1,3-Benzodioxol-5-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71578375	C22H15N3O5S	433.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC(=CC=C5)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BJ43EA	Tert-butyl 6-(2-chloro-4-pyridin-3-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	66546905	C27H25ClN6O2	501	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=CN=CC=C4)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BJ69QM	2-(2H-1,3-Benzodioxol-5-yl)-5-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-1,3,4-oxadiazole	Investigative	7458031	C22H16N2O3S	388.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BK59PQ	2-(1,3-Benzodioxol-5-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71578373	C22H15N3O5S	433.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BKJ7V6	Tert-Butyl 6-{[2-Chloro-4-(Dimethylcarbamoyl)phenyl]amino}-2-(1,3-Oxazol-5-Yl)-1h-Pyrrolo[3,2-C]pyridine-1-Carboxylate	Investigative	66548104	C24H24ClN5O4	481.9	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C(=O)N(C)C)Cl)C4=CN=CO4	IC50 = 75000 nM	Poor binder
T87675	Aurora kinase A	BKMO25	N-[2-Methoxy-5-(trifluoromethyl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	76317532	C19H16F3N5O	387.4	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=CC(=C4)C(F)(F)F)OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BLV6E5	CID 66547597	Investigative	66547597	C26H26ClN7O2	504	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=NN(C=C4)C)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BM69UH	CID 68290918	Investigative	68290918	C22H21ClN6O3S	485	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N5CCS(=O)(=O)CC5)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BMB67R	N-Phenyl-3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzamide	Investigative	124081229	C24H18F3N5O	449.4	C1=CC=C(C=C1)NC(=O)C2=CC(=CC=C2)NC3=NC=CC(=N3)NC4=CC=CC(=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BMED31	2-[4-[[5-[(3R)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	57523094	C26H21N3O4S	471.5	COC[C@@H]1COC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BMQ9S5	6-[2-Chloro-4-(5-oxazolyl)anilino]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester	Investigative	66546721	C25H23ClN6O3	490.9	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C4=CN=CO4)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BMW6E0	CID 66547759	Investigative	66547759	C27H29ClN6O5S	585.1	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C(=O)N4CCS(=O)(=O)CC4)Cl)C5=CN(N=C5)C	IC50 = 53000 nM	Poor binder
T87675	Aurora kinase A	BN0I2H	Chembl4281678	Investigative	110868446	C17H12FN3O2	309.29	C1=CC(=CC(=C1)F)C(=O)NC2=CC(=CNC2=O)C3=CC=NC=C3	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BN24SQ	2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide	Investigative	9548013	C9H4F3N3O4S2	339.3	C1=C(C=C(C2=C1[N+](=C(S2)C(=O)N)[O-])[N+](=O)[O-])SC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BN7JE6	Chembl4292942	Investigative	145989872	C19H17N3O4	351.4	COC1=CC(=CC(=C1)C(=O)NC2=CC(=CNC2=O)C3=CC=NC=C3)OC	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BN9QH5	Methyl 3-oxoisoindoline-4-carboxylate	Investigative	44579993	C10H9NO3	191.18	COC(=O)C1=CC=CC2=C1C(=O)NC2	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BNO9R7	4-N,4-N-Dimethyl-2-N,6-N-diphenylpyrimidine-2,4,6-triamine	Investigative	69896664	C18H19N5	305.4	CN(C)C1=NC(=NC(=C1)NC2=CC=CC=C2)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BNR85T	3-Amino-5-(quinolin-4-yl)pyridin-2(1H)-one	Investigative	57111159	C14H11N3O	237.26	C1=CC=C2C(=C1)C(=CC=N2)C3=CNC(=O)C(=C3)N	Ki = 76300 nM	Poor binder
T87675	Aurora kinase A	BNUQ61	7-Fluoroindirubin	Investigative	135423852	C16H9FN2O2	280.25	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4F)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BO02QN	2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71212395	C24H20N2O4S	432.5	COC1=CC=C(C=C1)C2=CC=C(C=C2)CSC3=NN=C(O3)C4=CC5=C(C=C4)OCCO5	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BO0JH1	2-[4-[[5-[(3S)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	57523095	C26H21N3O4S	471.5	COC[C@H]1COC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BOL3B8	Unii-WF9CA8UL2V	Investigative	60194098	C24H26N2O2	374.5	CC1=CC(=NC=C1)COC2=CC=CC(=C2C3=CC4=C(CCNCC4)C=C3)OC	IC50 ~ 50118.72 nM	Poor binder
T87675	Aurora kinase A	BOL48H	2-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzoic acid	Investigative	71472474	C18H13F3N4O2	374.3	C1=CC=C(C(=C1)C(=O)O)NC2=NC=CC(=N2)NC3=CC=CC(=C3)C(F)(F)F	IC50 = 64000 nM	Poor binder
T87675	Aurora kinase A	BOY6N9	N1-(3-Acetamidophenyl)-N2-(2-(2-(4-chlorophenyl)-4-methylthiazol-5-yl)ethyl)oxalamide	Investigative	27460865	C22H21ClN4O3S	456.9	CC1=C(SC(=N1)C2=CC=C(C=C2)Cl)CCNC(=O)C(=O)NC3=CC=CC(=C3)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BPF73C	6,7-Dimethoxy-4-(4-phenethylpiperazin-1-yl)quinazoline	Investigative	44433666	C22H26N4O2	378.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)CCC4=CC=CC=C4)OC	IC50 = 76000 nM	Poor binder
T87675	Aurora kinase A	BQTO97	N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide	Investigative	25271516	C27H26ClN5O3	504	COC1=CC=C(C=C1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BQV6B2	5-Fluoro-2-[4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile	Investigative	71578520	C21H13FN4OS	388.4	C1=CC(=CC=C1CSC2=NN=C(O2)C3=CC=NC=C3)C4=C(C=C(C=C4)F)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BR41TG	N-[2-Chloro-4-(4-methoxypiperidinocarbonyl)phenyl]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine	Investigative	68290875	C24H25ClN6O2	464.9	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=C(C=C(C=C4)C(=O)N5CCC(CC5)OC)Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BS0W8Z	2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	57522819	C24H17N3O3S	427.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BS1R6Q	2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole	Investigative	71212337	C23H17N3O5S	447.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC(=CC=C5)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BS25TZ	N-Cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide	Investigative	75202872	C28H30N6O3	498.6	CC1=C(C=CC(=C1)C2=C3N=C(N=C(N3N=C2)NCC4CCOCC4)OC5=CC=CC=C5)C(=O)NC6CC6	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BS4XD5	2-(4-(6,7-Dimethoxyquinazolin-4-yl)piperazin-1-yl)-1-(pyrrolidin-1-yl)ethanone	Investigative	44433668	C20H27N5O3	385.5	COC1=C(C=C2C(=C1)C(=NC=N2)N3CCN(CC3)CC(=O)N4CCCC4)OC	IC50 = 98000 nM	Poor binder
T87675	Aurora kinase A	BT4K2O	N-(4-Pyridin-4-yl-1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide	Investigative	5056270	C17H13N3O3S	339.4	C1C(OC2=CC=CC=C2O1)C(=O)NC3=NC(=CS3)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BTS57Z	Chembl4285109	Investigative	110868449	C18H15N3O3	321.3	COC1=CC=CC(=C1)C(=O)NC2=CC(=CNC2=O)C3=CC=NC=C3	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BTS9M3	3-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	71578374	C23H15N3O3S	413.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC(=C5)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BU8CG7	CID 68291016	Investigative	68291016	C26H27ClN6O3	507	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C(=O)N4CCC4)Cl)C5=CN(N=C5)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BUDM36	N-(5-Bromothiazol-2-yl)-2-(5-methoxybenzo[d]thiazol-2-ylthio)acetamide	Investigative	53322007	C13H10BrN3O2S3	416.3	COC1=CC2=C(C=C1)SC(=N2)SCC(=O)NC3=NC=C(S3)Br	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BUK1D4	Methyl 4-[[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]benzoate	Investigative	70694953	C19H16N2O5S	384.4	COC(=O)C1=CC=C(C=C1)CSC2=NN=C(O2)C3=CC4=C(C=C3)OCCO4	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BV18AR	(3Z)-7-Iodo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one	Investigative	135423784	C16H9IN2O2	388.16	C1=CC=C2C(=C1)C(=O)C(=N2)C3=C(NC4=C3C=CC=C4I)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BV26FR	N-(2-Chlorophenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine	Investigative	68291448	C17H14ClN5	323.8	CN1C=C(C=N1)C2=CC3=CN=C(C=C3N2)NC4=CC=CC=C4Cl	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BV51JC	7-Chloroindirubin-3-methoxime	Investigative	136104463	C17H12ClN3O2	325.7	CO/N=C\\1/C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC=C4Cl)O	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BV81NR	2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide	Investigative	12799331	C12H11N3O2	229.23	CC1=C(C=C(C(=O)N1)C(=O)N)C2=CC=NC=C2	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BVCM49	N-Ethyl-5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinamide	Investigative	135620678	C21H20N6O2	388.4	CCNC(=O)C1=CN=CC(=C1)/C=C/C2=C(NN=C2)C3=NC4=C(N3)C=C(C=C4)OC	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BVH0D3	5-Amino-1-methyl[3,4'-bipyridin]-6(1H)-one	Investigative	23339828	C11H11N3O	201.22	CN1C=C(C=C(C1=O)N)C2=CC=NC=C2	Ki = 99500 nM	Poor binder
T87675	Aurora kinase A	BVP2H0	Bisanilinopyrimidine, 4b	Investigative	70702133	C18H15N5O4	365.3	C1=CC=C(C(=C1)C(=O)O)NC2=NC(=NC(=C2)N)NC3=CC=C(C=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BVZ0F3	N-Benzyl-3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-N,5-dimethyl-1H-pyrazole-4-carboxamide	Investigative	25224081	C21H23N5O2	377.4	CC1=C(C(=NN1)N/N=C/C2=CC=C(C=C2)OC)C(=O)N(C)CC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BW6VA0	Chembl4279867	Investigative	11631251	C17H11F2N3O2	327.28	C1=CN=CC=C1C2=CNC(=O)C(=C2)NC(=O)C3=CC(=CC(=C3)F)F	Ki ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BWE0H2	3-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	71212291	C24H17N3O3S	427.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC(=C5)C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BX0F5D	Chembl4295011	Investigative	145993958	C9H8N4O	188.19	C1=C(C(=O)NC=C1C2=CN=CN=C2)N	Ki = 89600 nM	Poor binder
T87675	Aurora kinase A	BX80VR	2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[(4-phenylphenyl)methylsulfanyl]-1,3,4-oxadiazole	Investigative	71212419	C23H18N2O3S	402.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BYOS90	Tert-butyl 6-[2-chloro-4-(dimethylsulfamoyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate	Investigative	66548460	C24H27ClN6O4S	531	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)S(=O)(=O)N(C)C)Cl)C4=CN(N=C4)C	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BYQU48	4'-({[5-(2H-1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-[1,1'-biphenyl]-2-carbonitrile	Investigative	30291209	C23H15N3O3S	413.4	C1OC2=C(O1)C=C(C=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=CC=C5C#N	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	BYT6L9	3-Amino-5-phenyl-1H-pyridin-2-one	Investigative	25181368	C11H10N2O	186.21	C1=CC=C(C=C1)C2=CNC(=O)C(=C2)N	Ki = 66900 nM	Poor binder
T87675	Aurora kinase A	BZ0H3E	3-[(2E)-2-[(4-Methoxyphenyl)methylidene]hydrazinyl]-N,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide	Investigative	25223870	C20H21N5O2	363.4	CC1=C(C(=NN1)N/N=C/C2=CC=C(C=C2)OC)C(=O)N(C)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T87675	Aurora kinase A	BZM1D2	4-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile	Investigative	71212233	C24H17N3O3S	427.5	C1COC2=C(O1)C=CC(=C2)C3=NN=C(O3)SCC4=CC=C(C=C4)C5=CC=C(C=C5)C#N	IC50 = 50000 nM	Poor binder
T87675	Aurora kinase A	BZQ65A	2,4,6,6'-Tetramethoxy-2'-hydroxy-trans-chalcone	Investigative	71554422	C19H20O6	344.4	COC1=CC=CC(=C1C(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)O	IC50 = 66400 nM	Poor binder
T87675	Aurora kinase A	D00UTU	7-bromoindirubin-3-acetoxime	Investigative	136104465	C18H12BrN3O3	398.2	.	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	D0K6VW	7-iodoindirubin-3-oxime	Investigative	135423793	C16H10IN3O2	403.17	.	IC50 ~ 100000 nM	Poor binder
T87675	Aurora kinase A	D0K8YI	7-chloroindirubin-3-oxime	Investigative	135423791	C16H10ClN3O2	311.72	.	IC50 ~ 100000 nM	Poor binder