TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T87686	Histone-lysine N-methyltransferase	D06IAR	Adenosine	Approved	60961	C10H13N5O4	267.24	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N	IC50 = 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B1R7SU	1-{[6-(3-Fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-1,2,3-benzotriazole	Investigative	2030255	C16H10FN7S	351.4	C1=CC=C2C(=C1)N=NN2CC3=NN=C4N3N=C(S4)C5=CC(=CC=C5)F	IC50 = 55780 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B1XVY8	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(pyridin-4-ylmethylamino)methyl]oxolane-3,4-diol	Investigative	70677678	C16H19N7O3	357.37	C1=CN=CC=C1CNC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B29ZVO	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Investigative	78357767	C23H35N5O2	413.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B3J5FV	5-Benzyloxy-2-amino-1-methyl-1H-indole-3-carbonitrile	Investigative	22180710	C17H15N3O	277.32	CN1C2=C(C=C(C=C2)OCC3=CC=CC=C3)C(=C1N)C#N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B3NWJ8	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(thiophen-2-ylmethylamino)methyl]oxolane-3,4-diol	Investigative	70677679	C15H18N6O3S	362.4	C1=CSC(=C1)CNC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B42ZCK	S-Adenosyl-3-thiopropylamine	Investigative	171251	C13H20N6O3S	340.4	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCCCN)O)O)N	Ki = 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B4YX9S	Ethyl N-[3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]carbamate	Investigative	70677812	C16H24N6O5S	412.5	CCOC(=O)NCCCSC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B53MAQ	5'-Deoxy-5'-(2-hydroxyethylthio)adenosine	Investigative	9862185	C12H17N5O4S	327.36	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCCO)O)O)N	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B62GKH	3-[3-(1H-1,2,3-Benzotriazol-1-ylmethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl methyl ether	Investigative	1972282	C17H13N7OS	363.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3S2)CN4C5=CC=CC=C5N=N4	IC50 = 64150 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B7V2YB	5'-Deoxy-5'-(Prop-2-Yn-1-Ylamino)adenosine	Investigative	56835775	C13H16N6O3	304.3	C#CCNC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B81NIO	N-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]benzamide	Investigative	70677815	C20H24N6O4S	444.5	C1=CC=C(C=C1)C(=O)NCCCSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B86SXE	5'-S-(3-Aminophenyl)-5'-thioadenosine	Investigative	60074592	C16H18N6O3S	374.4	C1=CC(=CC(=C1)SC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	B8IH2L	1-[3-[[(1S,2R,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea	Investigative	76331683	C28H42N8O3	538.7	CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2C[C@H]([C@@H]([C@@H]2O)O)N3C=NC4=C(N=CN=C43)N	Ki ~ 50000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BA4M7I	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(pyridin-2-ylmethylamino)methyl]oxolane-3,4-diol	Investigative	70677532	C16H19N7O3	357.37	C1=CC=NC(=C1)CNC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BB6TG7	(2R)-2-Amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxypropanamide	Investigative	118735772	C18H17N5O3	351.4	C1=CC(=CC=C1NC(=O)[C@@H](CO)N)OC2=CC3=C(C=C2)NC(=C3C#N)N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BB8M4L	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-[(furan-2-ylmethylamino)methyl]oxolane-3,4-diol	Investigative	70677680	C15H18N6O4	346.34	C1=COC(=C1)CNC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BD3X9I	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide	Investigative	67466175	C29H35N7O2	513.6	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BEG3P8	(3R)-N-Methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine	Investigative	137655088	C12H17N5	231.3	CN[C@@H]1CCCN(C1)C2=NC=NC3=C2C=CN3	IC50 = 141000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BEX4M1	Chembl4281164	Investigative	22180716	C17H16N4O	292.33	CN1C2=C(C=C(C=C2)OCC3=CC(=CC=C3)N)C(=C1N)C#N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BF54BM	Cn1c(N)c(C#N)c2cc(Oc3ccc(NC(=O)CN)cc3)ccc12	Investigative	118735771	C18H17N5O2	335.4	CN1C2=C(C=C(C=C2)OC3=CC=C(C=C3)NC(=O)CN)C(=C1N)C#N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BIX9T0	N-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]naphthalene-2-carboxamide	Investigative	70677816	C24H26N6O4S	494.6	C1=CC=C2C=C(C=CC2=C1)C(=O)NCCCSC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BJ40VS	(2R,3S,4R,5R)-2-[(3-Aminopropylamino)methyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	9836890	C13H21N7O3	323.35	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CNCCCN)O)O)N	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BKC7N0	(2s)-2-Amino-N-[4-[(2-Amino-3-Cyano-1h-Indol-5-Yl)oxy]phenyl]-3-Hydroxy-Propanamide	Investigative	58619539	C18H17N5O3	351.4	C1=CC(=CC=C1NC(=O)[C@H](CO)N)OC2=CC3=C(C=C2)NC(=C3C#N)N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BLA4S9	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	Investigative	54596764	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BN65TK	N-[3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]-2-phenylacetamide	Investigative	70677814	C21H26N6O4S	458.5	C1=CC=C(C=C1)CC(=O)NCCCSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BNH3P5	5'-S-Benzyl-5'-thioadenosine	Investigative	44401736	C17H19N5O3S	373.4	C1=CC=C(C=C1)CSC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BOB86T	5-Benzyloxy-2-amino-1H-indole-3-carbonitrile	Investigative	22180707	C16H13N3O	263.29	C1=CC=C(C=C1)COC2=CC3=C(C=C2)NC(=C3C#N)N	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BOTA41	3-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methylsulfanyl]propanoic acid	Investigative	24764113	C13H17N5O5S	355.37	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCCC(=O)O)O)O)N	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BPT87C	Methyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoate	Investigative	1002773	C18H17N3O4S	371.4	COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3C(=O)OC	IC50 ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BQ61IN	Tert-butyl N-[3-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]propyl]carbamate	Investigative	70677682	C18H28N6O5S	440.5	CC(C)(C)OC(=O)NCCCSC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O	Ki = 50000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BR2M0B	1-{[6-(3,4-Dimethylphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]methyl}-1H-benzimidazole	Investigative	3159434	C19H16N6S	360.4	CC1=C(C=C(C=C1)C2=NN3C(=NN=C3S2)CN4C=NC5=CC=CC=C54)C	IC50 = 63970 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BUT5J4	(2R,3S,4R,5R)-2-[[(3-Aminophenyl)methyl-prop-2-enylamino]methyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	70677681	C20H25N7O3	411.5	C=CCN(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O)CC4=CC(=CC=C4)N	Ki ~ 100000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BVD01K	Chembl4295161	Investigative	145993747	C21H21N5O2	375.4	C1CC1CN2C3=C(C=C(C=C3)OC4=CC=C(C=C4)NC(=O)CN)C(=C2N)C#N	IC50 = 96000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	BVOJ07	CCn1c(N)c(C#N)c2cc(Oc3ccc(NC(=O)CN)cc3)ccc12	Investigative	118735770	C19H19N5O2	349.4	CCN1C2=C(C=C(C=C2)OC3=CC=C(C=C3)NC(=O)CN)C(=C1N)C#N	IC50 = 99000 nM	Poor binder
T87686	Histone-lysine N-methyltransferase	D02TVQ	GSK343	Investigative	71268957	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder