TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88304	DNA [cytosine-5]-methyltransferase 1	D02VTV	PMID27376512-Compound-Figure3CN	Patented	117968550	C38H38N6O	594.7	C1CN(CCC1COC2=CC3=C(C=C2)C(=NC=N3)NCC4=CC=C(C=C4)C5=CC=CC=C5)CCNC6=CC=NC7=CC=CC=C76	EC50 = 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B1H0RP	(2R,3S)-3-(1H-Indol-3-ylmethyl)-1-(naphthalene-2-carbonyl)pyrrolidine-2-carboxylic acid	Investigative	76332047	C25H22N2O3	398.5	C1CN([C@H]([C@H]1CC2=CNC3=CC=CC=C32)C(=O)O)C(=O)C4=CC5=CC=CC=C5C=C4	IC50 = 50000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B29ZVO	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Investigative	78357767	C23H35N5O2	413.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B2KQU7	4-Amino-N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)benzamide	Investigative	59457966	C18H18N6O	334.4	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)N	IC50 = 173000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B3C0NB	7-Methyl-3-[2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine	Investigative	327606	C16H16N6	292.34	CC1=CC2=NN=C(N2C=C1)CCC3=NN=C4N3C=CC(=C4)C	IC50 = 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B3FT4G	N,N-Dimethyl-1-[3-(4-nitrophenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanamine	Investigative	56643471	C12H15N3O3	249.27	CN(C)CC1CC(=NO1)C2=CC=C(C=C2)[N+](=O)[O-]	IC50 = 150000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B3N8SM	5'-{[(3s)-3-Amino-3-Carboxypropyl][2-(1-Benzothiophen-3-Yl)ethyl]amino}-5'-Deoxyadenosine	Investigative	70695988	C24H29N7O5S	527.6	C1=CC=C2C(=C1)C(=CS2)CCN(CC[C@@H](C(=O)O)N)C[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O	IC50 = 132000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B4EY3J	(2S,4R)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)piperidine-2-carboxylic acid	Investigative	45269774	C16H22N6O5S	410.5	C1CN[C@@H](C[C@@H]1SC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B69OEY	(2S,3R)-1-Benzoyl-3-(1H-indole-3-ylmethyl)pyrrolidine-2-carboxylic acid	Investigative	76310239	C21H20N2O3	348.4	C1CN([C@@H]([C@@H]1CC2=CNC3=CC=CC=C32)C(=O)O)C(=O)C4=CC=CC=C4	IC50 = 98000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	B93IYP	2-Amino-4-(((2S,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid	Investigative	45273102	C21H26N6O5S	474.5	C1=CC=C(C=C1)CNC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CSCCC(C(=O)O)N)O)O	IC50 = 61000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BCR6W4	(2R,3S,4R,5R)-2-(2-Amino-3-cyclohexylpropyl)-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	86288828	C18H28N6O3	376.5	C1CCC(CC1)CC(C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 179000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BD3X9I	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide	Investigative	67466175	C29H35N7O2	513.6	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BD6Z9B	C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Nc1ccccc1	Investigative	117967660	C33H37N7O	547.7	C1CN(CCC1COC2=CC3=C(C=C2)C(=NC=N3)NCCNC4=CC=CC=C4)CCNC5=CC=NC6=CC=CC=C65	EC50 = 73000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BGQB78	(2S,4S)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)-1-methylpyrrolidine-2-carboxylic acid	Investigative	45273088	C16H22N6O5S	410.5	CN1C[C@H](C[C@H]1C(=O)O)SC[C@@H]2[C@H](C([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BI4VX6	2-Amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid	Investigative	45268848	C15H22N6O6S	414.4	COC1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCCC(C(=O)O)N)O)O)N	IC50 = 75000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BIX2R1	Chembl4282866	Investigative	10451940	C19H20N2O2S2	372.5	CCN(CC)S(=O)(=O)C1=CC=C(C=C1)/C=C/C2=NC3=CC=CC=C3S2	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BKBP72	(2S,4R)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)pyrrolidine-2-carboxylic acid	Investigative	45271416	C15H20N6O5S	396.4	C1[C@H](CN[C@@H]1C(=O)O)SC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BKC0G2	4-[(2-Amino-6-methylpyrimidin-4-yl)amino]-N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]benzamide	Investigative	76314628	C23H23N9O	441.5	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)NC4=NC(=NC(=C4)C)N	IC50 = 68000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BL4RI8	(2R,3S)-1-Benzoyl-3-(1H-indol-3-ylmethyl)pyrrolidine-2-carboxylic acid	Investigative	76328372	C21H20N2O3	348.4	C1CN([C@H]([C@H]1CC2=CNC3=CC=CC=C32)C(=O)O)C(=O)C4=CC=CC=C4	IC50 = 73000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BLA4S9	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	Investigative	54596764	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C	IC50 = 121000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BM3SN7	(5S)-2-(4-Nitrophenyl)-5-(pyrrolidin-1-ylmethyl)-4,5-dihydro-1,3-oxazole	Investigative	24828467	C14H17N3O3	275.3	C1CCN(C1)C[C@H]2CN=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]	IC50 = 150000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BOP6Y7	N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide	Investigative	59457983	C27H23N7O	461.5	CC1=CC(=NC(=N1)N)NC2=CC(=CC=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54	IC50 = 52000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BP53UF	(2S,3R)-1-(2-Naphthoyl)-3-(1H-indole-3-ylmethyl)pyrrolidine-2-carboxylic acid	Investigative	76332046	C25H22N2O3	398.5	C1CN([C@@H]([C@@H]1CC2=CNC3=CC=CC=C32)C(=O)O)C(=O)C4=CC5=CC=CC=C5C=C4	IC50 = 128000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BPT87C	Methyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoate	Investigative	1002773	C18H17N3O4S	371.4	COC1=CC2=C(C=C1)N=C(N2)SCC(=O)NC3=CC=CC=C3C(=O)OC	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BQ7F2E	(2S,3R)-1-(2,4-Dinitrophenylthio)-3-[(1H-indole-3-yl)methyl]pyrrolidine-2-carboxylic acid	Investigative	76321200	C20H18N4O6S	442.4	C1CN([C@@H]([C@@H]1CC2=CNC3=CC=CC=C32)C(=O)O)SC4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]	IC50 = 80000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BU1H6T	2-Amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid	Investigative	45270523	C20H24N6O5S	460.5	C1=CC=C(C=C1)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CSCCC(C(=O)O)N)O)O	IC50 = 154000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BVP7X1	N-[2-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide	Investigative	76314627	C27H23N7O	461.5	CC1=CC(=NC(=N1)N)NC2=CC=CC=C2NC(=O)C3=CC(=CC=C3)NC4=CC=NC5=CC=CC=C54	IC50 = 174000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BYX50U	(S)-2-Amino-4-(((2s,3s,4r,5r)-5-(6-(3-Chlorobenzylamino)-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)methylthio)butanoic Acid	Investigative	49786972	C21H25ClN6O5S	509	C1=CC(=CC(=C1)Cl)CNC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CSCC[C@@H](C(=O)O)N)O)O	Ki ~ 50000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BZ1H9B	(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-(((1R,2S)-2-aminocyclopentylthio)methyl)tetrahydrofuran-3,4-diol	Investigative	45273097	C15H22N6O3S	366.4	C1C[C@@H]([C@@H](C1)SC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 94000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	BZ2B0L	(2R,4S)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)piperidine-2-carboxylic acid	Investigative	45272318	C16H22N6O5S	410.5	C1CN[C@H](C[C@H]1SC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	D02TVQ	GSK343	Investigative	71268957	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T88304	DNA [cytosine-5]-methyltransferase 1	D0BI4T	UNC0642	Investigative	53315878	C29H44F2N6O2	546.7	CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F	IC50 ~ 50000 nM	Poor binder