TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T88505	Nuclear factor erythroid 2-related factor 2	B0DMI3	(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	6537003	C20H17FN2O2	336.4	C1CN2C(CN/C(=C\\C(=O)C3=CC=C(C=C3)F)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B5DM0U	(3Z)-3-[2-(4-Methylphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	5816652	C21H20N2O2	332.4	CC1=CC=C(C=C1)C(=O)/C=C\\2/C(=O)N3CCC4=CC=CC=C4C3CN2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B5EM1I	(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-9-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712143	C21H19FN2O3	366.4	COC1=CC2=C(C=C1)C3CN/C(=C\\C(=O)C4=CC(=CC=C4)F)/C(=O)N3CC2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B5U4AC	3-[2-(3-Fluorophenyl)-2-oxoethylidene]-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinoline-4(11bH)-one	Investigative	72711494	C20H17FN2O2	336.4	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC=C3)F)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B6YEJ2	(3Z)-3-[2-Oxo-2-(4-phenylphenyl)ethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711269	C26H22N2O2	394.5	C1CN2C(CN/C(=C\\C(=O)C3=CC=C(C=C3)C4=CC=CC=C4)/C2=O)C5=CC=CC=C51	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B84ZPD	(3Z)-9,10-Dimethoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711734	C22H22N2O4	378.4	COC1=C(C=C2C3CN/C(=C\\C(=O)C4=CC=CC=C4)/C(=O)N3CCC2=C1)OC	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B8C7AY	(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711735	C22H21ClN2O4	412.9	COC1=C(C=C2C3CN/C(=C\\C(=O)C4=CC(=CC=C4)Cl)/C(=O)N3CCC2=C1)OC	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B8FO3T	(3Z)-3-[2-(3-Methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	5944124	C21H20N2O3	348.4	COC1=CC=CC(=C1)C(=O)/C=C\\2/C(=O)N3CCC4=CC=CC=C4C3CN2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B9K0EY	(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-8-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712141	C21H19FN2O3	366.4	COC1=CC=CC2=C1CCN3C2CN/C(=C\\C(=O)C4=CC=CC=C4F)/C3=O	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	B9MDW4	(3Z)-9,10-Dimethoxy-3-[2-(3-methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711940	C23H24N2O5	408.4	COC1=CC=CC(=C1)C(=O)/C=C\\2/C(=O)N3CCC4=CC(=C(C=C4C3CN2)OC)OC	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BA0K2P	(3Z)-3-[2-(2-Methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711495	C21H20N2O3	348.4	COC1=CC=CC=C1C(=O)/C=C\\2/C(=O)N3CCC4=CC=CC=C4C3CN2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BASR68	(3Z)-8-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711943	C21H20N2O3	348.4	COC1=CC=CC2=C1CCN3C2CN/C(=C\\C(=O)C4=CC=CC=C4)/C3=O	EC50 = 58540 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BB3J1F	(3Z)-3-[2-(3-Bromophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712147	C20H17BrN2O2	397.3	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC=C3)Br)/C2=O)C4=CC=CC=C41	EC50 = 59120 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BCD5G4	(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711263	C20H17ClN2O2	352.8	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC=C3)Cl)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BE4GW5	(3Z)-3-[2-(2,4-Dichlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711267	C20H16Cl2N2O2	387.3	C1CN2C(CN/C(=C\\C(=O)C3=C(C=C(C=C3)Cl)Cl)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BE70KT	(3Z)-10-Methoxy-3-[2-(3-nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711499	C21H19N3O5	393.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC(=CC=C4)[N+](=O)[O-])/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BE7M3H	(3Z)-9-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712142	C21H20N2O3	348.4	COC1=CC2=C(C=C1)C3CN/C(=C\\C(=O)C4=CC=CC=C4)/C(=O)N3CC2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BEP87N	(3Z)-3-[2-(2-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711493	C20H17N3O4	363.4	C1CN2C(CN/C(=C\\C(=O)C3=CC=CC=C3[N+](=O)[O-])/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BGJK69	(3Z)-3-[2-(3,4-Difluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711266	C20H16F2N2O2	354.3	C1CN2C(CN/C(=C\\C(=O)C3=CC(=C(C=C3)F)F)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BIGP61	(3Z)-3-[2-(3,5-Difluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712146	C20H16F2N2O2	354.3	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC(=C3)F)F)/C2=O)C4=CC=CC=C41	EC50 = 58860 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BIX7K9	(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711497	C21H19ClN2O3	382.8	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC(=CC=C4)Cl)/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BMS15N	(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711733	C21H19FN2O3	366.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC=C(C=C4)F)/C3=O)C=C1	EC50 = 87950 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BMVH71	(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711732	C21H19FN2O3	366.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC(=CC=C4)F)/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BNA8F3	(3Z)-10-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711496	C21H20N2O3	348.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC=CC=C4)/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BNIA05	(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711941	C22H21FN2O4	396.4	COC1=C(C=C2C3CN/C(=C\\C(=O)C4=CC(=CC=C4)F)/C(=O)N3CCC2=C1)OC	EC50 = 92000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BNL54I	(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-9-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712144	C21H19FN2O3	366.4	COC1=CC2=C(C=C1)C3CN/C(=C\\C(=O)C4=CC=CC=C4F)/C(=O)N3CC2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BNVF78	(3Z)-10-Methoxy-3-[2-(3-methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711731	C22H22N2O4	378.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC(=CC=C4)OC)/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BO7M4C	(3Z)-3-[2-(4-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	73355399	C20H17ClN2O2	352.8	C1CN2C(CN/C(=C\\C(=O)C3=CC=C(C=C3)Cl)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BP9UN7	(3Z)-3-[2-(2-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711039	C20H17ClN2O2	352.8	C1CN2C(CN/C(=C\\C(=O)C3=CC=CC=C3Cl)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BQ3Z2H	(3Z)-3-[2-(4-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711264	C20H17N3O4	363.4	C1CN2C(CN/C(=C\\C(=O)C3=CC=C(C=C3)[N+](=O)[O-])/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BQGE74	(3Z)-3-[2-(3-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711268	C20H17N3O4	363.4	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC=C3)[N+](=O)[O-])/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BQOF64	(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-8-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711944	C21H19FN2O3	366.4	COC1=CC=CC2=C1CCN3C2CN/C(=C\\C(=O)C4=CC(=CC=C4)F)/C3=O	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BS6F9Z	(3Z)-3-[2-(3,4-Dimethoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	5896779	C22H22N2O4	378.4	COC1=C(C=C(C=C1)C(=O)/C=C\\2/C(=O)N3CCC4=CC=CC=C4C3CN2)OC	EC50 = 93020 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BTSZ45	(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711942	C22H21FN2O4	396.4	COC1=C(C=C2C3CN/C(=C\\C(=O)C4=CC=C(C=C4)F)/C(=O)N3CCC2=C1)OC	EC50 = 81540 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BV7H8S	(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711736	C22H21FN2O4	396.4	COC1=C(C=C2C3CN/C(=C\\C(=O)C4=CC=CC=C4F)/C(=O)N3CCC2=C1)OC	EC50 = 75850 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BV97OP	(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711265	C20H17FN2O2	336.4	C1CN2C(CN/C(=C\\C(=O)C3=CC=CC=C3F)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BXB9G7	(3Z)-3-[2-Oxo-2-[3-(trifluoromethyl)phenyl]ethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72712145	C21H17F3N2O2	386.4	C1CN2C(CN/C(=C\\C(=O)C3=CC(=CC=C3)C(F)(F)F)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BXMS62	(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	72711498	C21H19FN2O3	366.4	COC1=CC2=C(CCN3C2CN/C(=C\\C(=O)C4=CC=CC=C4F)/C3=O)C=C1	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BYC1L5	CID 5788151	Investigative	5788151	C21H20N2O3	348.4	COC1=CC=C(C=C1)C(=O)/C=C\\2/C(=O)N3CCC4=CC=CC=C4C3CN2	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	BZQN43	3-(2-Oxo-2-phenylethylidene)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one	Investigative	5951878	C20H18N2O2	318.4	C1CN2C(CN/C(=C\\C(=O)C3=CC=CC=C3)/C2=O)C4=CC=CC=C41	EC50 ~ 100000 nM	Poor binder
T88505	Nuclear factor erythroid 2-related factor 2	D0DQ2G	2-tert-butylbenzene-1,4-diol	Investigative	16043	C10H14O2	166.22	CC(C)(C)C1=C(C=CC(=C1)O)O	EC50 = 91530 nM	Poor binder