TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T91940	NAD-dependent deacetylase sirtuin-5	D0E7PQ	Vorinostat	Approved	5311	C14H20N2O3	264.32	C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	D0Y3KG	Valproate	Approved	3121	C8H16O2	144.21	CCCC(CCC)C(=O)O	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	D0B7CH	Phenylbutyrate	Phase 2	4775	C10H12O2	164.2	C1=CC=C(C=C1)CCCC(=O)O	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B08COV	(2S)-4-Anilino-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid	Investigative	137640903	C20H17NO3S	351.4	C1=CC=C(C=C1)NC(=O)C[C@@H](C(=O)O)SC2=CC3=CC=CC=C3C=C2	IC50 = 157200 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B1V7XZ	Sirtinol	Investigative	2827646	C26H22N2O2	394.5	CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2N=CC3=C(C=CC4=CC=CC=C43)O	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B2FUQ6	(2S)-2-Naphthalen-2-ylsulfanyl-4-oxo-4-(3-phenylpropylamino)butanoic acid	Investigative	137639921	C23H23NO3S	393.5	C1=CC=C(C=C1)CCCNC(=O)C[C@@H](C(=O)O)SC2=CC3=CC=CC=C3C=C2	IC50 = 72560 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B2R9WV	(2S)-4-(Butylamino)-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid	Investigative	137661720	C18H21NO3S	331.4	CCCCNC(=O)C[C@@H](C(=O)O)SC1=CC2=CC=CC=C2C=C1	IC50 = 154000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B3JM9T	Nicotinamide	Investigative	936	C6H6N2O	122.12	C1=CC(=CN=C1)C(=O)N	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B7GK1V	4-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]butanoic acid	Investigative	122184882	C29H52N8O8S	672.8	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)NCCCC(=O)O)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	B8YA7Z	(2S)-4-(Benzylamino)-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid	Investigative	137661177	C21H19NO3S	365.4	C1=CC=C(C=C1)CNC(=O)C[C@@H](C(=O)O)SC2=CC3=CC=CC=C3C=C2	IC50 = 124000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BA1D6U	(5E)-5-[4-(Benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	Investigative	7333748	C21H18N2O3S	378.4	C=CCN1C(=O)/C(=C/C2=CC=C(C=C2)OCC3=CC=CC=C3)/C(=O)NC1=S	IC50 = 67300 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BBA79Z	Ethyl 3-[[(5S)-6-[[(2S)-6-acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoate	Investigative	122184884	C30H54N8O8S	686.9	CCOC(=O)CCNC(=S)NCCCC[C@@H](C(=O)N[C@@H](CCCCNC(=O)C)C(=O)N)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BCW4R6	Chembl4170094	Investigative	134820907	C26H26N6O3S	502.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CN(N=C4)C)C	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BE3YW2	3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one	Investigative	45168044	C28H26N4O2S	482.6	COC1=C(C2=CC=CC=C2C=C1)CN3C=NC4=C(C3=O)C5=C(S4)CC(CC5)NCC6=CN=CC=C6	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BJD20T	Chembl4128509	Investigative	145962411	C61H114N18O17S	1403.7	CCCCCCCCCCCCCNC(=O)CCCSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)N	IC50 ~ 50000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BLD0F7	(2S)-4-[3-(Methylcarbamoyl)anilino]-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid	Investigative	137655192	C22H20N2O4S	408.5	CNC(=O)C1=CC(=CC=C1)NC(=O)C[C@@H](C(=O)O)SC2=CC3=CC=CC=C3C=C2	IC50 = 90000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BMS49F	3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol	Investigative	56674921	C15H10Br2INO2	522.96	C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(N2)O	IC50 = 97800 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BN8L2M	2-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]acetic acid	Investigative	122184880	C27H48N8O8S	644.8	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)NCC(=O)O)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BQV36U	Chembl4295059	Investigative	145993578	C29H38N4O5S2	586.8	CCOC(=O)CCNC(=S)NCCCC[C@@H](C(=O)NC1CCSC2=CC=CC=C12)NC(=O)OCC3=CC=CC=C3	IC50 ~ 167000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	BT57UJ	1-Ethyl-6-hydroxy-5-[(Z)-indol-3-ylidenemethyl]-2-sulfanylidenepyrimidin-4-one	Investigative	135469837	C15H13N3O2S	299.3	CCN1C(=C(C(=O)NC1=S)/C=C/2\\C=NC3=CC=CC=C32)O	IC50 = 55900 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	D09SUO	splitomicin	Investigative	5269	C13H10O2	198.22	C1CC(=O)OC2=C1C3=CC=CC=C3C=C2	IC50 ~ 100000 nM	Poor binder
T91940	NAD-dependent deacetylase sirtuin-5	D0E3NT	AGK2	Investigative	2130404	C23H13Cl2N3O2	434.3	C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N	IC50 ~ 100000 nM	Poor binder