TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T91959	NAD-dependent deacetylase sirtuin-3	D0E3LP	SEN-196	Phase 2	5113032	C13H13ClN2O	248.71	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	D0MW0K	US9359293, TM	Patented	71533676	C33H49N3O3S	567.8	CCCCCCCCCCCCCC(=S)NCCCCC(C(=O)NC1=CC=CC=C1)NC(=O)OC2=CC=CC=C2	IC50 = 124000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	D0X9SE	US9359293, TB	Patented	122580127	C23H29N3O3S	427.6	CCCC(=S)NCCCCC(C(=O)NC1=CC=CC=C1)NC(=O)OC2=CC=CC=C2	IC50 = 113000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B0U5ZY	(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-[(2-iodoacetyl)amino]hexanoyl]amino]hexanamide	Investigative	134131007	C26H46IN7O7	695.6	CC(=O)NCCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=O)CI)NC(=O)[C@H](CCCCNC(=O)C)NC(=O)C	IC50 = 54200 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B1LGI7	5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Investigative	3953303	C20H17ClN4O3	396.8	C1CN(CCN1C2=C3C=CC=NC3=C(C=C2)[N+](=O)[O-])C(=O)C4=CC=C(C=C4)Cl	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B1OPK9	2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide	Investigative	1096292	C22H20N4OS2	420.6	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B1ZD0R	N-(2-(1-(Thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)pivalamide	Investigative	71654993	C18H26N4OS	346.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC=C3	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B2JUG0	2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	Investigative	1183103	C24H14F3N3O2	433.4	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=CC(=CC=C4)C(F)(F)F)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B4BJI1	N-(5-{3-[(1-Benzyl-1h-1,2,3-Triazol-4-Yl)methoxy]benzyl}-1,3-Thiazol-2-Yl)-2-[(4,6-Dimethylpyrimidin-2-Yl)sulfanyl]acetamide	Investigative	112499922	C28H27N7O2S2	557.7	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CC5=CC=CC=C5)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B4ME7N	(3S,16S)-3-[4-(Ethanethioylamino)butyl]-2,5,10-trioxo-1,4,7,11-tetrazacyclohexadecane-16-carboxamide	Investigative	134148882	C19H34N6O4S	442.6	CC(=S)NCCCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CCNCC(=O)N1)C(=O)N	IC50 = 56900 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B7AM9Y	4-(Ethylamino)thieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654838	C9H10N4OS	222.27	CCNC1=NC=NC2=C1SC(=C2)C(=O)N	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B8NU5C	Tenovin-6	Investigative	24772043	C25H34N4O2S	454.6	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C	IC50 = 82650 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	B9L1KI	2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide	Investigative	3612016	C14H15ClN2O	262.73	C1CCC2=C(C(C1)C(=O)N)NC3=C2C=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BA28QK	2-[3-[1-(2-Cyclopentylethyl)-1H-1,2,3-triazole-4-yl]anilino]benzamide	Investigative	77461130	C22H25N5O	375.5	C1CCC(C1)CCN2C=C(N=N2)C3=CC(=CC=C3)NC4=CC=CC=C4C(=O)N	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BA38WZ	5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124157054	C24H19N3O3S	429.5	C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)C3=CC=CS3)COC4=CN=CC(=C4)C(=O)N	IC50 = 66400 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BAD54G	N-(4-Bromopyridine-3-yl)-3-(naphthalene-2-yl)benzamide	Investigative	118722847	C22H15BrN2O	403.3	C1=CC=C2C=C(C=CC2=C1)C3=CC(=CC=C3)C(=O)NC4=C(C=CN=C4)Br	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BB17DF	(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide	Investigative	53379498	C23H42N8O6S	558.7	CC(=O)NCCC[C@@H](C(=O)N)NC(=O)[C@H](CCCCNC(=S)N)NC(=O)[C@H](CCCNC(=O)C)NC(=O)C	IC50 = 57200 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BB4RD9	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide	Investigative	1183106	C23H14ClN3O2	399.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4)Cl	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BCPR48	3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide	Investigative	1328033	C19H21BrN2O3S	437.4	C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BCW4R6	Chembl4170094	Investigative	134820907	C26H26N6O3S	502.6	CC1=CC(=NC(=N1)SCC(=O)NC2=CC=CC(=C2)COC3=CC=C(C=C3)NC(=O)C4=CN(N=C4)C)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BDGX05	5-[[3-[(4-Phenoxybenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide	Investigative	124156896	C26H21N3O4	439.5	C1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)NC3=CC=CC(=C3)COC4=CN=CC(=C4)C(=O)N	IC50 = 85800 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BE3YW2	3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one	Investigative	45168044	C28H26N4O2S	482.6	COC1=C(C2=CC=CC=C2C=C1)CN3C=NC4=C(C3=O)C5=C(S4)CC(CC5)NCC6=CN=CC=C6	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BEJG92	4-[[[4-Oxo-3-(quinolin-8-ylmethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-7-yl]amino]methyl]benzonitrile	Investigative	137661474	C28H23N5OS	477.6	C1CC2=C(CC1NCC3=CC=C(C=C3)C#N)SC4=C2C(=O)N(C=N4)CC5=CC=CC6=C5N=CC=C6	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BG9T5K	5-((1-Benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	Investigative	1142691	C20H15N3O2S	361.4	C1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)C=C4C(=O)NC(=S)NC4=O	IC50 = 116300 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BH5MA8	Chembl4227437	Investigative	135397680	C24H27N7O3S2	525.7	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCOC)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BH9SN3	N-Methyl-4-(4-(2-pivalamidoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654992	C20H29N5O2S	403.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)NC	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BI9C4U	3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide	Investigative	1183101	C23H14ClN3O2	399.8	C1=CC=C(C(=C1)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3N=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BIK6D1	Phenyl N-[1-anilino-6-(heptanethioylamino)-1-oxohexan-2-yl]carbamate	Investigative	122580128	C26H35N3O3S	469.6	CCCCCCC(=S)NCCCCC(C(=O)NC1=CC=CC=C1)NC(=O)OC2=CC=CC=C2	IC50 = 105000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BJ3F7I	Chembl4217034	Investigative	145972149	C31H34N2O4	498.6	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC5=C(C=C4)OCO5	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BJD20T	Chembl4128509	Investigative	145962411	C61H114N18O17S	1403.7	CCCCCCCCCCCCCNC(=O)CCCSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)N	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BL83OY	2-Cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide	Investigative	1183104	C24H14F3N3O2	433.4	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BLG23W	Chembl4218670	Investigative	145967555	C32H39N3O2	497.7	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC=C(C=C4)N(C)C	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BMO69Y	4-Chlorothieno[3,2-d]pyrimidine-6-carboxamide	Investigative	71654770	C7H4ClN3OS	213.65	C1=C(SC2=C1N=CN=C2Cl)C(=O)N	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BN05CU	(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate	Investigative	45483031	C22H27N3O3S	413.5	CC(=S)NCCCC[C@@H](C(=O)NC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BOB20C	Chembl4211748	Investigative	145966202	C31H36N2O4	500.6	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC(=C(C=C4)O)OC	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BOX17P	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide	Investigative	1183108	C23H13Cl2N3O2	434.3	C1=CC(=C(C(=C1)Cl)Cl)C2=CC=C(O2)/C=C(\\C#N)/C(=O)NC3=CC=CC4=C3C=CC=N4	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BP51EK	3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one	Investigative	121313586	C30H29N3O3S	511.6	COC1=CC=C(C=C1)CNC2CCC3=C(C2)SC4=C3C(=O)N(C=N4)CC5=C(C=CC6=CC=CC=C65)OC	IC50 = 177400 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BR4MQ3	4-[[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]carbamoyl]benzoic acid	Investigative	124156580	C21H17N3O5	391.4	C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)C(=O)O)COC3=CN=CC(=C3)C(=O)N	IC50 = 106000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BRG48W	6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	661302	C14H16N2O	228.29	CC1=CC2=C(C=C1)NC3=C2CCCC3C(=O)N	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BS1A2Q	N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide	Investigative	1096276	C18H18N4OS2	370.5	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC=C3)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BT61CY	2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide	Investigative	2130402	C23H13Cl2N3O2	434.3	C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C(=CC=C4)Cl)Cl)/C#N)N=CC=C2	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BUVK80	Chembl4225505	Investigative	145967841	C55H84N10O15S3	1221.5	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCC5C6C(CS5)NC(=O)N6)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BW27YL	4-[4-[2-(2,2-Dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxylic acid	Investigative	71654991	C19H26N4O3S	390.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BXH2S8	Sirt2-PROTAC-1	Investigative	135397670	C40H40N10O8S2	852.9	CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BY94DE	2-[4-(1-Benzyl-1H-1,2,3-triazole-4-yl)anilino]benzamide	Investigative	77461131	C22H19N5O	369.4	C1=CC=C(C=C1)CN2C=C(N=N2)C3=CC=C(C=C3)NC4=CC=CC=C4C(=O)N	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BZ0WF4	Chembl4218205	Investigative	145970505	C35H43N3O2	537.7	CCCCCCCCN1C2=C(C=C(C=C2)C(=O)OCC)N=C1C3=CC=C(C=C3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 50000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	BZ87UF	4-[(2-Chloro-6-hydroxyquinolin-5-yl)methyl]-5-(4-propan-2-ylphenyl)-1,2-dihydropyrazol-3-one	Investigative	90654863	C22H20ClN3O2	393.9	CC(C)C1=CC=C(C=C1)C2=C(C(=O)NN2)CC3=C(C=CC4=C3C=CC(=N4)Cl)O	IC50 = 122000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	D0E1QP	2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	Investigative	4262314	C13H14N2O	214.26	C1CC(C2=C(C1)C3=CC=CC=C3N2)C(=O)N	IC50 ~ 100000 nM	Poor binder
T91959	NAD-dependent deacetylase sirtuin-3	D0E3NT	AGK2	Investigative	2130404	C23H13Cl2N3O2	434.3	C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N	IC50 ~ 50000 nM	Poor binder