TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T94033	Coagulation factor IIa	D05TPI	EPICATECHIN	Phase 2	72276	C15H14O6	290.27	C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	IC50 = 150000 nM	Poor binder
T94033	Coagulation factor IIa	D08PBB	L-694,458	Phase 2	177992	C31H40N4O6	564.7	CCC[C@H](C1=CC2=C(C=C1)OCO2)NC(=O)N3[C@H](C(C3=O)(CC)CC)OC4=CC=C(C=C4)C(=O)N5CCN(CC5)C	IC50 = 78760 nM	Poor binder
T94033	Coagulation factor IIa	D0J9UI	YM60828	Terminated	9807238	C27H31N5O5S	537.6	CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)N(CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)S(=O)(=O)CC(=O)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B01FCM	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-2-oxopiperidine-4-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73350496	C24H26F3N5O8S	601.6	CCOC(=O)C1CCN(C(=O)C1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B03YCH	Chembl44010	Investigative	73345716	C26H41N5O9	567.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 106000 nM	Poor binder
T94033	Coagulation factor IIa	B06BIL	1-[4-[(5S)-5-[[[4-Chloro-3-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224837	C25H24ClN5O7	541.9	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B06IYD	2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-((S)-1-phenyl-ethyl)-acetamide	Investigative	11416498	C18H21N5O2	339.4	C[C@@H](C1=CC=CC=C1)NC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki = 50700 nM	Poor binder
T94033	Coagulation factor IIa	B08OTN	2-[3-(1H-1,3-Benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid	Investigative	135559071	C21H15N3O5	389.4	C1=CC=C2C(=C1)NC(=N2)C3=CC(=CC(=C3O)C4=CC(=CC=C4)[N+](=O)[O-])CC(=O)O	Ki ~ 150000 nM	Poor binder
T94033	Coagulation factor IIa	B09LDG	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid	Investigative	44364107	C24H29N5O4	451.5	CC(=N)N1CC[C@@H](C1)OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0BK6E	Chembl296315	Investigative	73354802	C28H43N5O10	609.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 54000 nM	Poor binder
T94033	Coagulation factor IIa	B0CBH4	(2S)-(3'-Amidino-3-biphenyl)-5-(4-pyridylamino)pentanoic acid	Investigative	5496928	C23H24N4O2	388.5	C1=CC(=CC(=C1)[C@H](CCCNC2=CC=NC=C2)C(=O)O)C3=CC(=CC=C3)C(=N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0DFW7	[2-[2-[3,5-Dicyano-6-nitro-4-(4-phenylmethoxyphenyl)pyridin-2-yl]sulfanylacetyl]-6-sulfooxyphenyl] hydrogen sulfate	Investigative	71517738	C28H18N4O12S3	698.7	C1=CC=C(C=C1)COC2=CC=C(C=C2)C3=C(C(=NC(=C3C#N)SCC(=O)C4=C(C(=CC=C4)OS(=O)(=O)O)OS(=O)(=O)O)[N+](=O)[O-])C#N	IC50 = 65900 nM	Poor binder
T94033	Coagulation factor IIa	B0H4SP	2-N-[(4-Carbamimidoylphenyl)methyl]-1-N-ethyl-1-N-(2-fluorophenyl)cyclopent-2-ene-1,2-dicarboxamide	Investigative	11090840	C23H25FN4O2	408.5	CCN(C1=CC=CC=C1F)C(=O)C2CCC=C2C(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 = 93000 nM	Poor binder
T94033	Coagulation factor IIa	B0H5FM	[4-((S)-1-Carbamimidoyl-pyrrolidin-3-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid	Investigative	44364106	C23H28N6O4	452.5	C1CN(C[C@H]1OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0JS7Q	4-[(2-Carbamimidoyl-3,4-dihydro-1H-isoquinolin-7-yl)oxymethyl]-1-pyrimidin-4-ylpiperidine-4-carboxylic acid;methanesulfonic acid	Investigative	44400527	C22H30N6O6S	506.6	CS(=O)(=O)O.C1CN(CC2=C1C=CC(=C2)OCC3(CCN(CC3)C4=NC=NC=C4)C(=O)O)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0KH8P	4-[(E)-(5-Oxo-2-phenyl-1,3-oxazol-4-ylidene)methyl]benzenecarboximidamide	Investigative	16220264	C17H13N3O2	291.3	C1=CC=C(C=C1)C2=N/C(=C/C3=CC=C(C=C3)C(=N)N)/C(=O)O2	IC50 = 56100 nM	Poor binder
T94033	Coagulation factor IIa	B0KXQ9	[4-((S)-1-Allyl-pyrrolidin-3-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid ethyl ester	Investigative	44364487	C27H34N4O4	478.6	CCOC(=O)C(C1=CC=C(C=C1)O[C@H]2CCN(C2)CC=C)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0MGN8	(2S)-1-[(2S,3As,7aS)-1-[(2R)-5-(diaminomethylideneamino)-2-methylpentanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]-N-[(2R)-1-[[(2S)-1-amino-3-(4-methylphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	57397633	C34H52N8O5	652.8	CC1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]3C[C@@H]4CCCC[C@@H]4N3C(=O)[C@H](C)CCCN=C(N)N	IC50 = 98000 nM	Poor binder
T94033	Coagulation factor IIa	B0N2LA	Pyrazinone Analog 24h	Investigative	10885426	C27H26ClN5O2	488	C1=CC=C(C=C1)CCNC2=NC(=C(N(C2=O)CC(=O)NCCC3=CC=NC=C3)C4=CC=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B0QY7M	3-Methyl-2-phenyl-1H-indole-5-carboxamidine	Investigative	44276519	C16H15N3	249.31	CC1=C(NC2=C1C=C(C=C2)C(=N)N)C3=CC=CC=C3	IC50 = 66000 nM	Poor binder
T94033	Coagulation factor IIa	B0USZ1	3-Carboxamide-coumarin deriv., 34	Investigative	24860448	C19H17NO3	307.3	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NC3=CC(=CC(=C3)C)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B0XYM1	Darexaban glucuronide	Investigative	10168444	C33H38N4O10	650.7	CN1CCCN(CC1)C2=CC=C(C=C2)C(=O)NC3=C(C=CC=C3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)NC(=O)C5=CC=C(C=C5)OC	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B18LUE	Cyclohex-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-(4-carbamimidoyl-benzylamide)	Investigative	11101217	C23H26N4O2	390.5	C1CC=C(C(C1)C(=O)NCC2=CC=C(C=C2)C(=N)N)C(=O)NCC3=CC=CC=C3	IC50 = 109000 nM	Poor binder
T94033	Coagulation factor IIa	B1AXW5	(R)-N-{(S)-2-(4-Cyano-phenyl)-1-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-ethyl}-3-phenyl-2-phenylmethanesulfonylamino-propionamide	Investigative	11125405	C35H38N8O5S2	714.9	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CC2=CC=C(C=C2)C#N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C3=NC=CS3)NS(=O)(=O)CC4=CC=CC=C4	IC50 = 50000 nM	Poor binder
T94033	Coagulation factor IIa	B1B0CM	Chembl296667	Investigative	73351801	C32H43N5O10	657.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 69000 nM	Poor binder
T94033	Coagulation factor IIa	B1CUF3	(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester	Investigative	10293977	C18H27N5O5	393.4	CC(C)(C)OC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N	Ki = 69000 nM	Poor binder
T94033	Coagulation factor IIa	B1GZ0D	US9585881, Example 111	Investigative	72547628	C26H31N5O6S	541.6	CS(=O)(=O)N1CCC(CC1)[C@H]2C[C@H](N(C2)C(=O)C3=CC=C(C=C3)C(=N)N)C(=O)NC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B1HZJ2	(2S)-5-(Diaminomethylideneamino)-N-[2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-(2-phenylethylsulfonylamino)pentanamide	Investigative	44287629	C22H37N9O5S	539.7	C1=CC=C(C=C1)CCS(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)NC(CCCN=C(N)N)C=O	IC50 = 64000 nM	Poor binder
T94033	Coagulation factor IIa	B1LCV9	N-[4-[1-[[2-[(4-Carbamimidoylphenyl)carbamoylamino]acetyl]amino]ethyl]phenyl]piperidine-4-carboxamide	Investigative	10389769	C24H31N7O3	465.5	CC(C1=CC=C(C=C1)NC(=O)C2CCNCC2)NC(=O)CNC(=O)NC3=CC=C(C=C3)C(=N)N	Ki = 68500 nM	Poor binder
T94033	Coagulation factor IIa	B1LZ9K	N-[(2R)-1-[4-(2-Hydroxyethyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamide	Investigative	44287130	C28H36N4O4S	524.7	CC1CC2=C(C(=CC=C2)S(=O)(=O)N[C@H](CC3=CNC4=CC=CC=C43)C(=O)N5CCC(CC5)CCO)NC1	Ki = 59900 nM	Poor binder
T94033	Coagulation factor IIa	B1M9DJ	1-N-[(4-Carbamimidoylphenyl)methyl]-2-N-(2-phenylethyl)cyclopentene-1,2-dicarboxamide	Investigative	11003663	C23H26N4O2	390.5	C1CC(=C(C1)C(=O)NCC2=CC=C(C=C2)C(=N)N)C(=O)NCCC3=CC=CC=C3	IC50 = 58000 nM	Poor binder
T94033	Coagulation factor IIa	B1MKC2	N-(5-Chloropyridine-2-yl)-2-[(1-isopropylpiperidine-4-yl)carbonylamino]-3-(beta-D-glucopyranuronosyloxy)-5-bromobenzamide	Investigative	57594784	C27H32BrClN4O9	671.9	CC(C)N1CCC(CC1)C(=O)NC2=C(C=C(C=C2O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O)Br)C(=O)NC4=NC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B1OS7A	Cyclohex-2-ene-1,2-dicarboxylic acid 1-(4-carbamimidoyl-benzylamide) 2-phenylamide	Investigative	11079334	C22H24N4O2	376.5	C1CC=C(C(C1)C(=O)NCC2=CC=C(C=C2)C(=N)N)C(=O)NC3=CC=CC=C3	IC50 = 130000 nM	Poor binder
T94033	Coagulation factor IIa	B1P4DT	2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-(1-methyl-1-phenyl-ethyl)-acetamide	Investigative	44282678	C19H23N5O2	353.4	CC(C)(C1=CC=CC=C1)NC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B1PVF9	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-(methanesulfonamido)-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Investigative	118548760	C25H34N6O3S	498.6	CS(=O)(=O)NC1CN(C(=O)N(C1)C2=CC=CC(=C2)C(=N)N)CC3CCN(CC3)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B1PYU6	N-(3-Guanidino-3-oxo-propyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide	Investigative	44346155	C19H28N6O5S	452.5	C1CCN(C(=O)[C@H](C1)NS(=O)(=O)CC2=CC=CC=C2)CC(=O)NCCC(=O)N=C(N)N	IC50 = 73000 nM	Poor binder
T94033	Coagulation factor IIa	B1Q9MT	(2S,3S)-N-[(1R)-1-[[3-(Butylamino)-3-oxopropyl]-diphenylsilyl]-3-methylbutyl]-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]pentanamide	Investigative	46221636	C42H55N3O3Si	678	CCCCNC(=O)CC[Si](C1=CC=CC=C1)(C2=CC=CC=C2)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CC3=CC4=CC=CC=C4C=C3	IC50 = 92000 nM	Poor binder
T94033	Coagulation factor IIa	B1QW9S	Benzyl (3aS,6aR)-6-allyl-4-(methylsulfonyl)-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate	Investigative	54132077	C18H22N2O5S	378.4	CS(=O)(=O)N1[C@H]2CCN([C@@H]2[C@H](C1=O)CC=C)C(=O)OCC3=CC=CC=C3	IC50 = 53170 nM	Poor binder
T94033	Coagulation factor IIa	B1R5AM	Propan-2-yl N-[(2R)-2-[2-[(4-carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-oxomorpholin-4-yl]carbamate	Investigative	11080884	C18H25N5O5	391.4	CC(C)OC(=O)NN1CCO[C@@H](C1=O)CC(=O)NCC2=CC=C(C=C2)C(=N)N	IC50 = 80600 nM	Poor binder
T94033	Coagulation factor IIa	B1VO2H	2-(1-Hydroxy-2-naphthyl)-1H-benzimidazole-5-carboxamidine	Investigative	135490854	C18H14N4O	302.3	C1=CC=C2C(=C1)C=CC(=C2O)C3=NC4=C(N3)C=C(C=C4)C(=N)N	Ki = 80000 nM	Poor binder
T94033	Coagulation factor IIa	B1XDJ2	D-Ser-Gly-(4-Amidinobenzyl)NH2	Investigative	9922131	C13H19N5O3	293.32	C1=CC(=CC=C1CNC(=O)CNC(=O)[C@@H](CO)N)C(=N)N	Ki = 200000 nM	Poor binder
T94033	Coagulation factor IIa	B1XR6K	2-Ketobenzothiazole 44	Investigative	11398046	C28H34N4O3S	506.7	CCCC[C@@H](C(=O)C1=NC2=CC=CC=C2S1)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](CC4=CC=CC=C4)NC	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B23FZM	N-[(4-Carbamimidoylphenyl)methyl]-2-[(2R)-3-oxo-4-(phenacylamino)morpholin-2-yl]acetamide	Investigative	54585528	C22H25N5O4	423.5	C1CO[C@@H](C(=O)N1NCC(=O)C2=CC=CC=C2)CC(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 ~ 133000 nM	Poor binder
T94033	Coagulation factor IIa	B24INB	4-[[(2S,4S)-1-(1-Carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550184	C24H35N7O6S	549.6	CS(=O)(=O)N1CCN(CC1)[C@H]2C[C@H](N(C2)C(=O)C3CCN(CC3)C(=N)N)C(=O)NC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B25GKP	1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[4-(4-piperidinyl)butyryl]piperazinocarbonyloxy]cyclooctane	Investigative	10439687	C36H56N8O6	696.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CCCC5CCNCC5	Ki = 102000 nM	Poor binder
T94033	Coagulation factor IIa	B26JUZ	4-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477683	C20H21F3N4O7S	518.5	C1=CC(=CC=C1C(=O)O)NC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 66000 nM	Poor binder
T94033	Coagulation factor IIa	B26LPQ	6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-3-yloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136034781	C18H18FN5O2	355.4	C1CNCC1OC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 50000 nM	Poor binder
T94033	Coagulation factor IIa	B27NKA	Benzyl (3aS,6aR)-6-allyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate	Investigative	10661946	C17H20N2O3	300.35	C=CC[C@@H]1[C@@H]2[C@H](CCN2C(=O)OCC3=CC=CC=C3)NC1=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B28ELR	Ethyl 1-[4-[(5S)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	71699203	C25H29ClN4O5	501	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B29HLS	((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-guanidino-butyl)-carbamic acid ethyl ester	Investigative	9911275	C17H33N9O5	443.5	CCOC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B29YTW	2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide	Investigative	10861643	C17H25FN2O4S	372.5	CC(C)C[C@H](C=O)NC(=O)[C@H](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B2C1NS	(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394249	C37H57N7O6	695.9	CCCC(C(=O)C(=O)N[C@H](C)CC)NC(=O)[C@@H]1C2CCCC2CN1C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C3CCCCC3)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B2CNS4	(2S)-1-Acetyl-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	45139979	C15H21ClN4O2	324.8	CC(=O)N1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N.Cl	Ki = 56100 nM	Poor binder
T94033	Coagulation factor IIa	B2FK8U	Chembl296946	Investigative	73354804	C28H45N5O8	579.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 194000 nM	Poor binder
T94033	Coagulation factor IIa	B2FRK5	N-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[(S)-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethyl)-4-phenylmethanesulfonyl-piperazin-1-yl]-acetamide	Investigative	44376323	C29H40N8O6S2	660.8	C1CCN(CC1)C(=O)C[C@H]2C(=O)N(CCN2S(=O)(=O)CC3=CC=CC=C3)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C4=NC=CS4	IC50 = 60000 nM	Poor binder
T94033	Coagulation factor IIa	B2KR8Z	((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-ureido-butyl)-carbamic acid tert-butyl ester	Investigative	54352954	C19H36N8O6	472.5	CC(C)(C)OC(=O)N[C@H](CCCNC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B2L5DU	N-[(2S)-1-(4-Methylpiperidin-1-yl)-1-oxo-5-(pyrimidin-2-ylamino)pentan-2-yl]naphthalene-2-sulfonamide	Investigative	18657596	C25H31N5O3S	481.6	CC1CCN(CC1)C(=O)[C@H](CCCNC2=NC=CC=N2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	IC50 ~ 115000 nM	Poor binder
T94033	Coagulation factor IIa	B2LF5C	N-[2-(3-Carbamimidoyl-phenoxy)-ethyl]-4-(pyrrolidine-1-carbonyl)-benzamide	Investigative	11036285	C21H24N4O3	380.4	C1CCN(C1)C(=O)C2=CC=C(C=C2)C(=O)NCCOC3=CC=CC(=C3)C(=N)N	Ki = 110000 nM	Poor binder
T94033	Coagulation factor IIa	B2MCJ3	4-Guanidinophenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409735	C18H14ClN3O4	371.8	C1=CC(=CC=C1N=C(N)N)OC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 = 151000 nM	Poor binder
T94033	Coagulation factor IIa	B2NC1J	2-(1H-Benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole-5-carboxamidine	Investigative	44407625	C15H12N6	276.3	C1=CC=C2C(=C1)NC(=N2)C3=NC4=C(N3)C=C(C=C4)C(=N)N	Ki = 113000 nM	Poor binder
T94033	Coagulation factor IIa	B2NM8W	2-[(S)-3-(3-Guanidino-propyl)-2,5-dioxo-piperazin-1-yl]-N-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376731	C19H30N10O4S	494.6	C1C(=O)N[C@H](C(=O)N1CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2)CCCN=C(N)N	IC50 = 150000 nM	Poor binder
T94033	Coagulation factor IIa	B2PRQ3	N-(4-Amidinobenzyl)-N'-benzylcyclopentane-1alpha,2beta-dicarboxamide	Investigative	10785917	C22H26N4O2	378.5	C1C[C@@H]([C@H](C1)C(=O)NCC2=CC=C(C=C2)C(=N)N)C(=O)NCC3=CC=CC=C3	IC50 ~ 132000 nM	Poor binder
T94033	Coagulation factor IIa	B2QJ7K	Acetic acid;(2S)-2-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-1,2-dicarboxamide	Investigative	137648564	C16H23N5O4	349.38	CC(=O)O.C1C[C@H](N(C1)C(=O)N)C(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 59000 nM	Poor binder
T94033	Coagulation factor IIa	B2RZI1	({[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-methyl}-amino)-acetic acid	Investigative	11849331	C22H25N5O4	423.5	C1C2=CC=CC=C2CC1(C(=O)NCC3=CC=C(C=C3)C(=N)N)NC(=O)CNCC(=O)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	B2UYS9	2-Ketobenzothiazole 22	Investigative	18943987	C14H17N5O2S	319.38	C1=CC=C2C(=C1)N=C(S2)C(=O)C(CCCN=C(N)N)NC=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B2W7OY	3-Carboxamide-coumarin deriv., 43	Investigative	24860449	C18H13Cl2NO3	362.2	CC1=CC(=CC(=C1)NC(=O)C2=CC3=CC(=CC(=C3OC2=O)Cl)Cl)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B2YFI7	2-Methoxy-3,5-dichlorobenzenesulfonic acid 5-methyl-3-(3-hydroxyphenethyloxy)phenyl ester	Investigative	11092075	C22H20Cl2O6S	483.4	CC1=CC(=CC(=C1)OS(=O)(=O)C2=C(C(=CC(=C2)Cl)Cl)OC)OCCC3=CC(=CC=C3)O	IC50 = 56234.13 nM	Poor binder
T94033	Coagulation factor IIa	B30KIF	Methyl 3-[4-[(6-methoxynaphthalene-2-carbonyl)amino]phenyl]benzoate	Investigative	57403083	C26H21NO4	411.4	COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=CC(=CC=C4)C(=O)OC	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	B30SGZ	6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5-dimethoxy-phenyl)-amide	Investigative	11450922	C20H19N3O3	349.4	COC1=CC(=CC(=C1)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)C(=N)N)OC	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	B30WZK	trans-N-(2-(5-Chloro-1H-indole-2-carboxamido)cycloheptyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide	Investigative	44441287	C24H28ClN5O2S	486	CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3CCCCC[C@H]3NC(=O)C4=CC5=C(N4)C=CC(=C5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B31XPW	5-Amino-N,1-bis[(3-carbamimidoylphenyl)methyl]indole-2-carboxamide	Investigative	11826299	C25H25N7O	439.5	C1=CC(=CC(=C1)C(=N)N)CNC(=O)C2=CC3=C(N2CC4=CC(=CC=C4)C(=N)N)C=CC(=C3)N	Ki = 99000 nM	Poor binder
T94033	Coagulation factor IIa	B34DKG	[4-[3-(Aminomethyl)phenyl]piperidin-1-yl]-[5-(2-pyridin-2-ylethynyl)furan-2-yl]methanone;2,2,2-trifluoroacetic acid	Investigative	57396788	C26H24F3N3O4	499.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=N4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B35PTJ	N-(Trifluoromethylsulfonyl)-D-Phe-L-Pro-(4-guanidinobutyl)NH2	Investigative	44363514	C20H29F3N6O4S	506.5	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=CC=C2)NS(=O)(=O)C(F)(F)F)C(=O)NCCCCN=C(N)N	IC50 = 110000 nM	Poor binder
T94033	Coagulation factor IIa	B38EDC	Tame	Investigative	1550286	C14H22N4O4S	342.42	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)OC	IC50 = 89000 nM	Poor binder
T94033	Coagulation factor IIa	B38PWI	Chembl46614	Investigative	73353276	C33H45N5O10	671.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 200000 nM	Poor binder
T94033	Coagulation factor IIa	B38UWM	[4-(1-Acetyl-piperidin-4-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid ethyl ester	Investigative	44364205	C27H34N4O5	494.6	CCOC(=O)C(C1=CC=C(C=C1)OC2CCN(CC2)C(=O)C)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B39FGY	3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide	Investigative	44304139	C15H15BrN4O2	363.21	CC1=CC(=C(C(=C1)Br)O)C(=O)NC2=CC=C(C=C2)N=C(N)N	Ki = 125000 nM	Poor binder
T94033	Coagulation factor IIa	B3A8UQ	2-(Benzylsulfonylamino)-4-(1-oxidopyridin-1-ium-2-yl)-N-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]butanamide	Investigative	44426222	C23H26N4O5S2	502.6	C1=CC=C(C=C1)CS(=O)(=O)NC(CCC2=CC=CC=[N+]2[O-])C(=O)NCC(=O)NCC3=CC=CS3	Ki = 140000 nM	Poor binder
T94033	Coagulation factor IIa	B3B5ZJ	3-[(3-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71458631	C15H18ClN3O3S	355.8	COC1=CC=CC(=C1)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 165000 nM	Poor binder
T94033	Coagulation factor IIa	B3CS2P	3-Carboxamide-coumarin deriv., 46	Investigative	24860451	C18H13BrClNO3	406.7	CC1=CC(=CC(=C1)NC(=O)C2=CC3=CC(=CC(=C3OC2=O)Br)Cl)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B3H8WP	N-[[(3S,3Ar)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzothiazin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713018	C20H18ClN3O5S2	480	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CS3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B3M9CD	4-[[(2S,4S)-1-[4-(Aminomethyl)cyclohexanecarbonyl]-4-(4-cyclopropylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550405	C27H39N5O6S	561.7	C1CC(CCC1CN)C(=O)N2C[C@H](C[C@H]2C(=O)NC3=CC=C(C=C3)C(=O)O)N4CCN(CC4)S(=O)(=O)C5CC5	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B3MYV9	(S)-2-{(S)-2-[(S)-2-(5-Amino-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10347184	C30H42N4O5	538.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCN	IC50 = 57100 nM	Poor binder
T94033	Coagulation factor IIa	B3QTV6	Pyrazinone Analog 24j	Investigative	10951082	C26H27ClN6O2	491	CN1C=C(N=C1)CCNC(=O)CN2C(=C(N=C(C2=O)NCCC3=CC=CC=C3)Cl)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B3RMB7	3-Amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-3-chloro-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl]benzoic acid	Investigative	9936190	C24H26ClN7O4	512	CC(C)NC1=NC(=C(N(C1=O)CC(=O)NCC2=CC=C(C=C2)C(=N)N)C3=CC(=CC(=C3)N)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B3RWQ8	Chembl44990	Investigative	73347216	C26H41N5O8	551.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 183000 nM	Poor binder
T94033	Coagulation factor IIa	B3TWQ1	(2S)-N-[[3-[3-(4-Amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-2-hydroxyphenyl]phenyl]methyl]-2-hydroxy-3-phenylpropanamide	Investigative	44415581	C29H26N4O3	478.5	C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC(=CC=C2)C3=C(C(=CC=C3)C4=CC5=C(N4)C=CN=C5N)O)O	Ki = 99000 nM	Poor binder
T94033	Coagulation factor IIa	B3UPV7	3-Phenylbenzenecarboximidamide	Investigative	3564407	C13H12N2	196.25	C1=CC=C(C=C1)C2=CC(=CC=C2)C(=N)N	Ki = 158489.32 nM	Poor binder
T94033	Coagulation factor IIa	B3W0VJ	2-(4-Diethylamino-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine	Investigative	135544579	C18H21N5O	323.4	CCN(CC)C1=CC(=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N)O	Ki = 90000 nM	Poor binder
T94033	Coagulation factor IIa	B3Y5CM	3-[3-[2-(1-Benzylpiperidin-4-yl)ethyl]-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Investigative	127034099	C26H35N5O	433.6	CC1CN(C(=O)N(C1)C2=CC=CC(=C2)C(=N)N)CCC3CCN(CC3)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B3YO5T	({3-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2-hydroxyphenyl]-4-hydroxyphenyl}methyl)urea	Investigative	135528873	C22H20N6O3	416.4	C1=CC(=C(C(=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N)O)C4=C(C=CC(=C4)CNC(=O)N)O	Ki = 90000 nM	Poor binder
T94033	Coagulation factor IIa	B41YXL	N-(2-Phenoxyethyl)pyridin-4-amine	Investigative	44459487	C13H14N2O	214.26	C1=CC=C(C=C1)OCCNC2=CC=NC=C2	Ki = 120000 nM	Poor binder
T94033	Coagulation factor IIa	B45NTB	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73356536	C25H28F3N5O8S	615.6	CCOC(=O)C1(CCCN(C1=O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N)C.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B47CTI	(3As,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester	Investigative	44351162	C27H26N2O5S	490.6	C=CC[C@@H]1C2[C@H](CCN2C(=O)OCC3=CC=CC=C3)N(C1=O)S(=O)(=O)C4=CC=CC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B4CJ5A	1beta-[[4-(4-Amidinophenylacetyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane	Investigative	44289295	C35H54N8O6	682.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)C(=N)N	Ki = 94400 nM	Poor binder
T94033	Coagulation factor IIa	B4D1IW	(2S)-1-[(2S)-2-[[3-(3-Aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-2-carboxylic acid	Investigative	44573428	C25H32N6O6S	544.6	C1CCN([C@@H](C1)C(=O)O)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCN	Ki = 159000 nM	Poor binder
T94033	Coagulation factor IIa	B4DF6I	(S)-3-(4-Aminomethyl-phenyl)-N-benzyl-2-(naphthalene-2-sulfonylamino)-propionamide	Investigative	44376924	C27H27N3O3S	473.6	C1=CC=C(C=C1)CNC(=O)[C@H](CC2=CC=C(C=C2)CN)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 97200 nM	Poor binder
T94033	Coagulation factor IIa	B4FKV9	Pyrazinone Analog 24k	Investigative	10896528	C28H25ClN6O2	513	C1=CC=C(C=C1)CCNC2=NC(=C(N(C2=O)CC(=O)NCC3=NC4=CC=CC=C4N3)C5=CC=CC=C5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B4I8PA	(3R,6R,8As)-6-amino-N-[4-(diaminomethylideneamino)butyl]-5-oxo-2,3,6,7,8,8a-hexahydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxamide;2,2,2-trifluoroacetic acid	Investigative	44346969	C15H25F3N6O4S	442.5	C1C[C@H]2N([C@@H](CS2)C(=O)NCCCCN=C(N)N)C(=O)[C@@H]1N.C(=O)(C(F)(F)F)O	Ki = 62400 nM	Poor binder
T94033	Coagulation factor IIa	B4O0CL	N-[(2S)-5-(Diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[(3R)-3-[3-(diaminomethylideneamino)propyl]-2-oxopiperazin-1-yl]acetamide	Investigative	44453135	C19H32N10O3S	480.6	C1CN(C(=O)[C@H](N1)CCCN=C(N)N)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2	IC50 = 200000 nM	Poor binder
T94033	Coagulation factor IIa	B4P5MY	4-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]butanamide;hydrochloride	Investigative	71462164	C20H27ClN4O5S	471	COC1=C(C=C(C=C1)CNC(=O)CCCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl	Ki = 60000 nM	Poor binder
T94033	Coagulation factor IIa	B4PV7O	2-[[(2S,3S)-2-[[(2S)-1-[(2S)-6-Amino-2-[(2,5-dihydroxybenzoyl)amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]butanoic acid	Investigative	73345705	C28H43N5O8	577.7	CC[C@H](C)[C@@H](C(=O)NC(CC)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 160000 nM	Poor binder
T94033	Coagulation factor IIa	B4RD3N	N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[(3S)-3-amino-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45268704	C20H22F3N5O4S	485.5	CC1=C(C=CC(=N1)N)CNC(=O)CN2C3=CC=CC=C3SC[C@H](C2=O)N.C(=O)(C(F)(F)F)O	IC50 = 88000 nM	Poor binder
T94033	Coagulation factor IIa	B4UJA1	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137637214	C117H160N32O28S3	2558.9	C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](CSCC3=CC4=CC(=C3)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N[C@@H](CSC4)C(=O)N6CCC[C@H]6C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)O)CC7=CNC8=CC=CC=C87)CC9=CNC1=CC=CC=C19)CC(=O)N)CC1=CNC2=CC=CC=C21)[C@@H](C)O)CC(=O)N)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)CC(C)C	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B4Z7PU	2-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]acetamide;hydrochloride	Investigative	71458635	C18H23ClN4O5S	442.9	COC1=C(C=C(C=C1)CNC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	Ki = 172000 nM	Poor binder
T94033	Coagulation factor IIa	B50UAL	1-[4-[(5R)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	73348934	C22H24F3N5O7S	559.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B51LFM	4-Chloro-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	11824584	C21H16ClN3O	361.8	C1=CC=C(C=C1)C2=C(C(=CC=C2)C3=CC4=C(N3)C=CC(=C4Cl)C(=N)N)O	Ki = 65000 nM	Poor binder
T94033	Coagulation factor IIa	B57JZT	N-(2-(3-(4-(Aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide	Investigative	10296435	C22H26ClN3O2S	432	C1=CC=C2C(=C1)C=CC(=C2Cl)S(=O)(=O)NCCNCCCC3=CC=C(C=C3)CN	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B57VLH	[2-[1,2-Bis(2-fluorophenyl)ethyl]-1H-indol-5-yl]methanamine	Investigative	44276508	C23H20F2N2	362.4	C1=CC=C(C(=C1)CC(C2=CC=CC=C2F)C3=CC4=C(N3)C=CC(=C4)CN)F	IC50 = 59000 nM	Poor binder
T94033	Coagulation factor IIa	B59GSO	N-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-guanidine	Investigative	44416510	C14H22BN3O2	275.16	B1(OC(C(O1)(C)C)(C)C)C2=CC=C(C=C2)CN=C(N)N	IC50 = 129000 nM	Poor binder
T94033	Coagulation factor IIa	B59SWA	Chembl4208878	Investigative	57404340	C24H23N5O2	413.5	C1=CC=C(C=C1)CN2C=CN=C2C[N+]3=CC=CC(=C3C(=O)NC4=CC=C(C=C4)CN)[O-]	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B5EGF0	2-Guanidinoethyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate	Investigative	44409732	C14H14ClN3O4	323.73	C1=CC2=C(C=C1CCl)C=C(C(=O)O2)C(=O)OCCN=C(N)N	IC50 = 107000 nM	Poor binder
T94033	Coagulation factor IIa	B5G0QS	Chembl365415	Investigative	15955412	C34H51N7O6	653.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)(C)C)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B5J9FW	2-(2-{2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-3,3-difluoro-propyl)-amide	Investigative	3011892	C35H49F2N7O6	701.8	CC(C)(C)[C@@H](C(=O)N1CC2CCCC2[C@H]1C(=O)NC(CC(F)F)C(=O)C(=O)NC3CC3)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B5JL9F	2-[2-Hydroxy-3-(cyclopentyloxy)phenyl]-6-chloro-1H-benzimidazole-5-carboxamidine	Investigative	136092215	C19H19ClN4O2	370.8	C1CCC(C1)OC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)Cl	Ki = 165000 nM	Poor binder
T94033	Coagulation factor IIa	B5K9CX	3-Carboxamide-coumarin deriv., 30	Investigative	24860447	C18H15NO3	293.3	CC1=CC=C(C=C1)NC(=O)C2=CC3=C(C=CC(=C3)C)OC2=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B5NK9L	4-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide	Investigative	127033522	C25H33N5O	419.6	CC1CN(C(=O)N(C1)C2CCN(CC2)CC3=CC=CC=C3)CC4=CC=C(C=C4)C(=N)N	Ki = 82200 nM	Poor binder
T94033	Coagulation factor IIa	B5PJX1	2-(3-Methoxy-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine	Investigative	135427245	C15H14N4O2	282.3	COC1=CC=CC(=C1O)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 80000 nM	Poor binder
T94033	Coagulation factor IIa	B5PZ4T	Chembl4217251	Investigative	16214382	C93H130N20O37	2120.1	C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC5=CN=CN5)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]6CCCN6)O	IC50 = 130000 nM	Poor binder
T94033	Coagulation factor IIa	B5RU2E	2-Ketobenzothiazole 72	Investigative	11318991	C31H39N5O3S	561.7	CN[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(=O)C3=NC4=CC=CC=C4S3)C5CCC(CC5)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B5S0RF	4-[[(2S,4R)-1-(3-Chloro-4-fluoro-1-methylindole-5-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550847	C28H30ClFN4O6S	605.1	CN1C=C(C2=C1C=CC(=C2F)C(=O)N3C[C@H](C[C@H]3C(=O)NC4=CC=C(C=C4)C(=O)O)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B5X7IK	(S)-3-Amino-N-(3-(N-(3-(3-carbamimidoylphenyl)-1-oxo-1-(piperazin-1-yl)propan-2-yl)sulfamoyl)phenyl)propanamide	Investigative	25031099	C23H31N7O4S	501.6	C1CN(CCN1)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC=CC(=C3)NC(=O)CCN	Ki = 71700 nM	Poor binder
T94033	Coagulation factor IIa	B60UQK	N-(3-Chlorobenzyl)-1-(4-Methylpentanoyl)-L-Prolinamide	Investigative	42615253	C18H25ClN2O2	336.9	CC(C)CCC(=O)N1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 109000 nM	Poor binder
T94033	Coagulation factor IIa	B60YUE	1,7-Di{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbonyl]hexahydro-1-pyrazinyl}-1,7-heptanedione	Investigative	44340290	C35H40N8O6	668.7	C1CN(CCN1C(=O)CCCCCC(=O)N2CCN(CC2)C(=O)C3=CC4=C(O3)C=CC(=C4)C(=N)N)C(=O)C5=CC6=C(O5)C=CC(=C6)C(=N)N	Ki = 85000 nM	Poor binder
T94033	Coagulation factor IIa	B62QKI	6-Methoxy-N-[4-(3-methoxyphenyl)phenyl]naphthalene-2-carboxamide	Investigative	57390824	C25H21NO3	383.4	COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=CC(=CC=C4)OC	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	B6B7XI	3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid	Investigative	9821317	C18H23FN2O6	382.4	CC(C)[C@@H](C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B6J0GX	Benzyl N-[2-(4-aminophenyl)-1-diphenoxyphosphorylethyl]carbamate	Investigative	87360663	C28H27N2O5P	502.5	C1=CC=C(C=C1)COC(=O)NC(CC2=CC=C(C=C2)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 62000 nM	Poor binder
T94033	Coagulation factor IIa	B6JPN7	4-[4-[1-[2-(4-Chlorophenyl)acetyl]-6-methoxy-4-oxo-2H-quinazolin-3-yl]phenyl]morpholin-3-one	Investigative	137652563	C27H24ClN3O5	505.9	COC1=CC2=C(C=C1)N(CN(C2=O)C3=CC=C(C=C3)N4CCOCC4=O)C(=O)CC5=CC=C(C=C5)Cl	IC50 = 81000 nM	Poor binder
T94033	Coagulation factor IIa	B6KAZ9	(2S)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)-N-[2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]pentanamide	Investigative	44287745	C21H35N9O5S	525.6	C1=CC=C(C=C1)CS(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)NC(CCCN=C(N)N)C=O	IC50 = 50000 nM	Poor binder
T94033	Coagulation factor IIa	B6MQT3	N-(4-Amidinophenyl)-2-hydroxy-3-phenylbenzamide	Investigative	44303804	C20H17N3O2	331.4	C1=CC=C(C=C1)C2=C(C(=CC=C2)C(=O)NC3=CC=C(C=C3)C(=N)N)O	Ki = 120000 nM	Poor binder
T94033	Coagulation factor IIa	B6O4XP	[(R)-1-({[2-(5-Amino-2H-[1,2,4]triazol-3-yl)-ethylcarbamoyl]-methyl}-cyclopentyl-carbamoyl)-2-cyclohexyl-ethylamino]-acetic acid	Investigative	44346069	C22H37N7O5	479.6	C1CCC(CC1)C[C@H](C(=O)N(CC(=O)ONCCC2=NC(=NN2)N)C3CCCC3)NCC(=O)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	B6PSY3	4-(4-Guanidinobenzoyloxy)phenylacetic acid	Investigative	130394	C17H19N3O7S	409.4	CS(=O)(=O)O.C1=CC(=CC=C1CC(=O)O)OC(=O)C2=CC=C(C=C2)N=C(N)N	IC50 = 107500 nM	Poor binder
T94033	Coagulation factor IIa	B6RI4S	6-Hydroxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	135450980	C21H17N3O2	343.4	C1=CC=C(C=C1)C2=C(C(=CC=C2)C3=CC4=CC(=C(C=C4N3)O)C(=N)N)O	Ki ~ 75000 nM	Poor binder
T94033	Coagulation factor IIa	B6RZU0	[4-(1-Carbamimidoyl-piperidin-4-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid	Investigative	44364382	C24H30N6O4	466.5	C1CN(CCC1OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B6T1BH	((R)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester	Investigative	73351777	C19H37N9O5	471.6	CC(C)(C)OC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 = 79000 nM	Poor binder
T94033	Coagulation factor IIa	B6TGU3	1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224849	C25H27N5O6	493.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNCC4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B6V7UT	(2R)-N-[(2S)-1-[(4-Carbamimidoylphenyl)methylamino]-4-methylsulfanyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide	Investigative	44587317	C18H27N5O2S	377.5	CSCC[C@@H](C(=O)NCC1=CC=C(C=C1)C(=N)N)NC(=O)[C@H]2CCCN2	IC50 = 83000 nM	Poor binder
T94033	Coagulation factor IIa	B6VSZ1	3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide	Investigative	44303935	C22H19N5O3	401.4	COC1=C(C(=CC2=CC3=CC=CC=C3C=C21)C(=O)NC4=CN=C(C=C4)N=C(N)N)O	Ki = 195000 nM	Poor binder
T94033	Coagulation factor IIa	B6WVF0	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-(4-{1-[imino-(4-methoxy-phenyl)-methyl]-piperidin-4-yloxy}-phenyl)-acetic acid	Investigative	44342242	C31H35N5O5	557.6	COC1=CC=C(C=C1)C(=N)N2CCC(CC2)OC3=CC=C(C=C3)C(C(=O)O)OC4=CC5=C(CCN(C5)C(=N)N)C=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B6Z7NS	(S)-N-(3-Chlorobenzyl)-1-(3-methylbutanoyl)pyrrolidine-2-carboxamide	Investigative	45141150	C17H23ClN2O2	322.8	CC(C)CC(=O)N1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl	Ki = 155000 nM	Poor binder
T94033	Coagulation factor IIa	B74SWK	(2S)-6-Amino-N-[(2S)-6-amino-1-[(1-carbamimidoylpiperidin-4-yl)methylamino]-1-oxohexan-2-yl]-2-[[2-(3-phenylphenyl)acetyl]amino]hexanamide	Investigative	72708122	C33H50N8O3	606.8	C1CN(CCC1CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC2=CC(=CC=C2)C3=CC=CC=C3)C(=N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B74ZDP	3-[(3-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71454985	C14H16ClN3O3S	341.8	COC1=CC=CC(=C1)NS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 165000 nM	Poor binder
T94033	Coagulation factor IIa	B7CBX5	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-[4-(tetrahydro-pyran-4-yloxy)-phenyl]-acetic acid	Investigative	44364329	C23H27N3O5	425.5	C1COCCC1OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B7EM3Z	Diphenyl 1-[(N-p-methylbenzoyl-D-seryl)-L-alanyl]amino-2-(4-guanidinophenyl)ethanephosphonate	Investigative	16086346	C35H39N6O7P	686.7	CC1=CC=C(C=C1)C(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)NC(CC2=CC=C(C=C2)N=C(N)N)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4	IC50 = 67000 nM	Poor binder
T94033	Coagulation factor IIa	B7IK6N	Chembl4208864	Investigative	9905436	C15H6F5NO2	327.2	C1=CC(=C(C(=C1)F)C2=NC3=C(C=CC(=C3)C(F)(F)F)C(=O)O2)F	IC50 = 134000 nM	Poor binder
T94033	Coagulation factor IIa	B7JME8	2-Ketobenzothiazole 46	Investigative	11785967	C28H37N7O2S	535.7	CN[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)CC3=NC4=CC=CC=C4S3	IC50 = 58000 nM	Poor binder
T94033	Coagulation factor IIa	B7K9MP	3-Carboxamide-coumarin deriv., 26	Investigative	24860438	C22H17NO3	343.4	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NCC3=CC=CC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B7MZY6	Acetic acid;(2S)-N-[(4-carbamimidoylphenyl)methyl]-1-sulfamoylpyrrolidine-2-carboxamide	Investigative	137644461	C15H23N5O5S	385.4	CC(=O)O.C1C[C@H](N(C1)S(=O)(=O)N)C(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 163000 nM	Poor binder
T94033	Coagulation factor IIa	B7QOW5	N-[3-(3-Amino-propoxy)-5-methyl-phenyl]-benzenesulfonamide	Investigative	44288203	C16H20N2O3S	320.4	CC1=CC(=CC(=C1)OCCCN)NS(=O)(=O)C2=CC=CC=C2	Ki = 170000 nM	Poor binder
T94033	Coagulation factor IIa	B80YRB	Tert-butyl 3-[[2-[(4-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477222	C22H25F3N4O7S	546.5	CC(C)(C)OC(=O)C1=CC(=CC=C1)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 64000 nM	Poor binder
T94033	Coagulation factor IIa	B81PHM	1-(4-Cyclohexyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide	Investigative	44333242	C21H37N5O3	407.6	C1CCC(CC1)CCCC(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C=O	EC50 = 56000 nM	Poor binder
T94033	Coagulation factor IIa	B83ZDA	[4-(1-Acetyl-piperidin-4-yloxy)-phenyl]-(2-carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-acetic acid	Investigative	44364177	C25H30N4O5	466.5	CC(=O)N1CCC(CC1)OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B84EJI	(2S)-2-Hydroxy-N-[[3-[2-hydroxy-3-(1H-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylpropanamide	Investigative	44415561	C29H25N3O3	463.5	C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC(=CC=C2)C3=C(C(=CC=C3)C4=CC5=C(N4)C=CN=C5)O)O	Ki = 100000 nM	Poor binder
T94033	Coagulation factor IIa	B8C3YI	2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-3-hydroxyphenyl)methyl]acetamide	Investigative	136104458	C24H26ClN7O3	496	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=CC(=C(C=C3)C(=N)N)O)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B8E9DZ	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(5,5-dimethyl-3-oxo-cyclohex-1-enyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid	Investigative	44364311	C30H36N4O5	532.6	CC1(CC(=CC(=O)C1)N2CC[C@@H](C2)OC3=CC=C(C=C3)C(C(=O)O)OC4=CC5=C(CCN(C5)C(=N)N)C=C4)C	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B8G7RC	(3Aalpha,6aalpha)-3beta,6beta-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxy]hexahydrofuro[3,2-b]furan	Investigative	9896889	C34H46N12O8	750.8	C1CN(CCN1C(=O)NCC2=CC=C(C=C2)N=C(N)N)C(=O)O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N	Ki = 138000 nM	Poor binder
T94033	Coagulation factor IIa	B8HM0B	6-Methoxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	10959252	C22H19N3O2	357.4	COC1=C(C=C2C=C(NC2=C1)C3=CC=CC(=C3O)C4=CC=CC=C4)C(=N)N	Ki ~ 75000 nM	Poor binder
T94033	Coagulation factor IIa	B8IW9Z	(2R)-2-(Benzylcarbamoylamino)-5-(diaminomethylideneamino)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]pentanamide	Investigative	73350271	C22H36N10O4	504.6	C1=CC=C(C=C1)CNC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 = 170000 nM	Poor binder
T94033	Coagulation factor IIa	B8JY9W	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(5,5-dimethyl-3-oxo-cyclohex-1-enyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid ethyl ester	Investigative	44364043	C32H40N4O5	560.7	CCOC(=O)C(C1=CC=C(C=C1)O[C@H]2CCN(C2)C3=CC(=O)CC(C3)(C)C)OC4=CC5=C(CCN(C5)C(=N)N)C=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B8ML2X	Chembl296538	Investigative	73348715	C29H47N5O8	593.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 137000 nM	Poor binder
T94033	Coagulation factor IIa	B8MN5R	6-Methyl-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide	Investigative	24860446	C18H15NO3	293.3	CC1=CC(=CC=C1)NC(=O)C2=CC3=C(C=CC(=C3)C)OC2=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	B8PW6F	4-[4-[1-[2-(5-Chlorothiophen-2-yl)acetyl]-6-methoxy-4-oxo-2H-quinazolin-3-yl]phenyl]morpholin-3-one	Investigative	137643322	C25H22ClN3O5S	512	COC1=CC2=C(C=C1)N(CN(C2=O)C3=CC=C(C=C3)N4CCOCC4=O)C(=O)CC5=CC=C(S5)Cl	IC50 = 67000 nM	Poor binder
T94033	Coagulation factor IIa	B8ZP6N	[4-(3-Aminomethylphenyl)-piperidin-1-yl]-[5-(2-fluorophenylethynyl)-furan-2-yl]-methanone trifluoroacetate	Investigative	57395169	C27H24F4N2O4	516.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	B90FUM	1,4-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]bicyclo[2.2.2]octane	Investigative	22010118	C38H54N12O6	774.9	C1CC2(CCC1(CC2)COC(=O)N3CCN(CC3)C(=O)NCC4=CC=C(C=C4)N=C(N)N)COC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N	Ki = 123000 nM	Poor binder
T94033	Coagulation factor IIa	B91NKL	5-Amino-1-[(3-carbamimidoylphenyl)methyl]-N-[(1-methylpyridin-1-ium-4-yl)methyl]indole-2-carboxamide;2,2,2-trifluoroacetate	Investigative	11734113	C26H25F3N6O3	526.5	C[N+]1=CC=C(C=C1)CNC(=O)C2=CC3=C(N2CC4=CC(=CC=C4)C(=N)N)C=CC(=C3)N.C(=O)(C(F)(F)F)[O-]	Ki = 57000 nM	Poor binder
T94033	Coagulation factor IIa	B98VCB	4-Aminobenzamidine dihydrochloride	Investigative	75626	C7H11Cl2N3	208.09	C1=CC(=CC=C1C(=N)N)N.Cl.Cl	Ki = 95000 nM	Poor binder
T94033	Coagulation factor IIa	B9H1UB	6-Chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indole-5-carboximidamide	Investigative	445844	C21H16ClN3O	361.8	C1=CC=C(C=C1)C2=C(C(=CC=C2)C3=CC4=CC(=C(C=C4N3)Cl)C(=N)N)O	Ki = 60000 nM	Poor binder
T94033	Coagulation factor IIa	B9I2UG	2-[(3S)-3-Acetamido-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]-N-[(6-amino-2-methylpyridin-3-yl)methyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45272123	C22H24F3N5O5S	527.5	CC1=C(C=CC(=N1)N)CNC(=O)CN2C3=CC=CC=C3SC[C@H](C2=O)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 = 133000 nM	Poor binder
T94033	Coagulation factor IIa	B9J4MC	Chembl44715	Investigative	73356324	C32H45N5O8	627.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 195000 nM	Poor binder
T94033	Coagulation factor IIa	B9VH7N	Pyridin-4-yl-{2-[3-(toluene-4-sulfonylamino)-phenoxy]-ethyl}-carbamic acid tert-butyl ester	Investigative	10863817	C25H29N3O5S	483.6	CC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=CC=C2)OCCN(C3=CC=NC=C3)C(=O)OC(C)(C)C	Ki = 90000 nM	Poor binder
T94033	Coagulation factor IIa	B9VZ0G	Tert-butyl N-[(2R)-2-[2-[(4-carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-oxomorpholin-4-yl]carbamate	Investigative	10994256	C19H27N5O5	405.4	CC(C)(C)OC(=O)NN1CCO[C@@H](C1=O)CC(=O)NCC2=CC=C(C=C2)C(=N)N	IC50 = 54700 nM	Poor binder
T94033	Coagulation factor IIa	BA0O3D	N-[1-(4-Acetylamino-phenyl)-ethyl]-2-[3-(4-carbamimidoyl-phenyl)-ureido]-acetamide	Investigative	44348177	C20H24N6O3	396.4	CC(C1=CC=C(C=C1)NC(=O)C)NC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BA4D2M	(2S)-1-[(2R)-2-Amino-2-cyclohexylethyl]-N-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	118736073	C20H31Cl2N3O	400.4	C1CCC(CC1)[C@H](CN2CCC[C@H]2C(=O)NCC3=CC(=CC=C3)Cl)N.Cl	Ki = 76000 nM	Poor binder
T94033	Coagulation factor IIa	BA6NY7	3-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide	Investigative	127033521	C25H33N5O	419.6	CC1CN(C(=O)N(C1)C2CCN(CC2)CC3=CC=CC=C3)CC4=CC(=CC=C4)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BA6QC9	N-(4-Carbamimidoyl-phenyl)-2-hydroxy-5-nitro-benzamide	Investigative	44303808	C14H12N4O4	300.27	C1=CC(=CC=C1C(=N)N)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])O	Ki = 185000 nM	Poor binder
T94033	Coagulation factor IIa	BA9H5Q	N-[2-[(6-Aminopyridin-3-yl)methylamino]-2-oxoethyl]-2-(benzylsulfonylamino)-4-(1-oxidopyridin-1-ium-2-yl)butanamide	Investigative	44426215	C24H28N6O5S	512.6	C1=CC=C(C=C1)CS(=O)(=O)NC(CCC2=CC=CC=[N+]2[O-])C(=O)NCC(=O)NCC3=CN=C(C=C3)N	Ki = 88000 nM	Poor binder
T94033	Coagulation factor IIa	BAE9Z4	4-[[(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550186	C26H26ClN7O5	552	C1COCCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=C(C=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BAI63W	3-[(4-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71456773	C14H16ClN3O3S	341.8	COC1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 71000 nM	Poor binder
T94033	Coagulation factor IIa	BAR36D	3-[4-Carbamimidoyl-2-[2-[(1-pyridin-4-ylpiperidine-4-carbonyl)amino]ethoxy]phenyl]-2-oxopropanoic acid	Investigative	10961420	C23H27N5O5	453.5	C1CN(CCC1C(=O)NCCOC2=C(C=CC(=C2)C(=N)N)CC(=O)C(=O)O)C3=CC=NC=C3	Ki = 140000 nM	Poor binder
T94033	Coagulation factor IIa	BAUK64	(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate	Investigative	15984063	C26H32N4O5	480.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)OCCC3=CC=CC=C3	Ki = 64000 nM	Poor binder
T94033	Coagulation factor IIa	BAV1F2	Sodium;[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-6-methoxy-2-(morpholin-4-ylmethyl)-1-benzofuran-5-yl]oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate	Investigative	53392971	C30H32NNaO14S	685.6	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)OC)CN5CCOCC5.[Na+]	IC50 = 128824.96 nM	Poor binder
T94033	Coagulation factor IIa	BAX9K5	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73356532	C24H28F3N5O7S	587.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB0JA7	4-[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Investigative	127033248	C24H31N5O	405.5	CC1CN(C(=O)N(C1)C2=CC=C(C=C2)C(=N)N)C3CCN(CC3)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB0Z2T	Unii-WJ9EV5WM6Q	Investigative	9869799	C26H29ClN4O3	481	CC(=N)N1CC[C@@H](C1)OC2=CC=C(C=C2)[C@H](CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)C(=O)O.Cl	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB16XW	2-{5-[Amino(iminio)methyl]-1H-benzimidazol-2-YL}benzenolate	Investigative	1506	C14H12N4O	252.27	C1=CC=C(C(=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N)O	Ki = 55000 nM	Poor binder
T94033	Coagulation factor IIa	BB1T0O	(R)-N-[(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-(3-trifluoromethyl-phenyl)-ethyl]-3-phenyl-2-phenylmethanesulfonylamino-propionamide	Investigative	10996309	C35H38F3N7O5S2	757.8	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CC2=CC(=CC=C2)C(F)(F)F)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C3=NC=CS3)NS(=O)(=O)CC4=CC=CC=C4	IC50 = 84900 nM	Poor binder
T94033	Coagulation factor IIa	BB27WK	(2S)-1-[(2R)-2-Amino-4-methylpentyl]-N-[(3-chlorophenyl)methyl]pyrrolidine-2-carboxamide;hydrochloride	Investigative	118736071	C18H29Cl2N3O	374.3	CC(C)C[C@H](CN1CCC[C@H]1C(=O)NCC2=CC(=CC=C2)Cl)N.Cl	Ki = 136000 nM	Poor binder
T94033	Coagulation factor IIa	BB3NP9	4-[5-(3,5-Bis-trifluoromethyl-benzenesulfonylamino)-1-methyl-1H-benzoimidazol-2-ylmethyl]-benzamidine	Investigative	11813669	C24H19F6N5O2S	555.5	CN1C2=C(C=C(C=C2)NS(=O)(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N=C1CC4=CC=C(C=C4)C(=N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB4EU2	3-[[(3R,3Ar,6aS)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-3-yl]methyl]benzenecarboximidamide;acetic acid	Investigative	44331422	C17H22N2O4	318.4	CC(=O)O.C1C[C@H]2[C@H](C1)OC(=O)[C@@H]2CC3=CC(=CC=C3)C(=N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB4FJ2	(2S,3S)-N-[(2S)-1-[[2-(Butylamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]-3-methyl-2-[(2-naphthalen-2-ylacetyl)amino]pentanamide	Investigative	71455698	C30H44N4O4	524.7	CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CC1=CC2=CC=CC=C2C=C1	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BB6M2Y	[(1S)-2-(4-Methoxyphenyl)-1-[[(2R)-3-naphthalen-2-yl-2-(phenylmethoxycarbonylamino)propanoyl]amino]ethyl]-phenylphosphinic acid	Investigative	44301758	C36H35N2O6P	622.6	COC1=CC=C(C=C1)C[C@@H](NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)OCC4=CC=CC=C4)P(=O)(C5=CC=CC=C5)O	IC50 = 70000 nM	Poor binder
T94033	Coagulation factor IIa	BBM9E4	Acetic acid;ethyl 1-[4-[(5R)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73353476	C28H37N5O6	539.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNCC4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BBN20J	3-[4-Carbamimidoyl-2-(2-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzoylamino}-ethoxy)-phenyl]-2-oxo-propionic acid	Investigative	9870947	C26H31N5O6	509.6	CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)C(=O)NCCOC3=C(C=CC(=C3)C(=N)N)CC(=O)C(=O)O	Ki = 53000 nM	Poor binder
T94033	Coagulation factor IIa	BBQ6Y8	1-N-[(2R)-5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-2-N-methyl-2-N-(2-phenylethyl)cyclohexane-1,2-dicarboxamide	Investigative	44457766	C23H35N5O3	429.6	CN(CCC1=CC=CC=C1)C(=O)C2CCCCC2C(=O)N[C@H](CCCN=C(N)N)C=O	IC50 = 84000 nM	Poor binder
T94033	Coagulation factor IIa	BBXK17	4-[[5-[(4-Carbamimidoylphenyl)methoxy]naphthalen-1-yl]oxymethyl]benzenecarboximidamide;hydrochloride	Investigative	90643746	C26H25ClN4O2	461	C1=CC2=C(C=CC=C2OCC3=CC=C(C=C3)C(=N)N)C(=C1)OCC4=CC=C(C=C4)C(=N)N.Cl	IC50 = 80000 nM	Poor binder
T94033	Coagulation factor IIa	BBYA79	(2S)-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S)-21-[[(2S)-2-[(2-Aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]-15-(4-aminobutyl)-9-(carboxymethyl)-29-[3-(diaminomethylideneamino)propyl]-18-[(1R)-1-hydroxyethyl]-12-(hydroxymethyl)-2,8,11,14,17,20,28,31-octaoxo-23,24-dithia-1,7,10,13,16,19,27,30-octazatricyclo[30.3.0.03,7]pentatriacontane-26-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	Investigative	122192780	C53H87N21O17S2	1354.5	C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CN)C(=O)N[C@@H](CC4=CN=CN4)C(=O)O)CCCN=C(N)N)CC(=O)O)CO)CCCCN)O	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BC3Z8N	3-[(3,4-Dimethoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride	Investigative	71458629	C15H18ClN3O4S	371.8	COC1=C(C=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl	Ki = 120000 nM	Poor binder
T94033	Coagulation factor IIa	BC45NR	(2S)-2-[[(2S)-2-(5-Aminopentanoylamino)-3-phenylpropanoyl]amino]-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-4-methylpentanamide	Investigative	10255784	C29H42N4O4	510.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCN	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BC4PZ0	4-[[(2S,4S)-1-(4-Carbamimidoylbenzoyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid	Investigative	72550185	C25H30N6O6S	542.6	CS(=O)(=O)N1CCN(CC1)[C@H]2C[C@H](N(C2)C(=O)C3=CC=C(C=C3)C(=N)N)C(=O)NC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BC5XK3	3-[[6-[(3-Carbamimidoylphenoxy)methyl]naphthalen-2-yl]methoxy]benzenecarboximidamide;hydrochloride	Investigative	90643753	C26H25ClN4O2	461	C1=CC(=CC(=C1)OCC2=CC3=C(C=C2)C=C(C=C3)COC4=CC=CC(=C4)C(=N)N)C(=N)N.Cl	IC50 = 72000 nM	Poor binder
T94033	Coagulation factor IIa	BC9N4R	Nazumamide A	Investigative	10008817	C28H43N7O8	605.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 53000 nM	Poor binder
T94033	Coagulation factor IIa	BCA21L	1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224848	C25H25N5O7	507.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BCA2D3	Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[4-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate	Investigative	137647340	C38H18Na8O38S8	1523	C1=CC(=CC=C1COC2=CC(=CC3=C2C(=O)C(=C(O3)C4=CC(=C(C=C4)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COC5=CC(=CC6=C5C(=O)C(=C(O6)C7=CC(=C(C=C7)OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]	IC50 = 156000 nM	Poor binder
T94033	Coagulation factor IIa	BCEN75	(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-[(3S)-3-methyl-4-sulfamoylpiperazin-1-yl]-N-phenylpyrrolidine-2-carboxamide	Investigative	90033784	C26H30ClN9O4S	600.1	C[C@H]1CN(CCN1S(=O)(=O)N)[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BCG61S	N-[(4-Carbamimidoylphenyl)methyl]-2-[(4-carbamimidoylphenyl)sulfonylamino]acetamide;2,2,2-trifluoroacetic acid	Investigative	71477832	C21H22F6N6O7S	616.5	C1=CC(=CC=C1CNC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)C(=N)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O	Ki = 125000 nM	Poor binder
T94033	Coagulation factor IIa	BCG7X5	US10336741, Example 96	Investigative	72550850	C29H41ClN6O5S	621.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCC(CC4)CN)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BCI72N	3-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]propanoic acid	Investigative	25107569	C21H22N4O6	426.4	CN1C2=C(C=C(C=C2)C(=O)NCCC(=O)O)OC(C1=O)OCC3=CC=C(C=C3)C(=N)N	Ki = 118000 nM	Poor binder
T94033	Coagulation factor IIa	BCKD46	6-Fluoro-2-[2-hydroxy-3-(piperidin-3-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136092210	C20H22FN5O2	383.4	C1CC(CNC1)COC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 50000 nM	Poor binder
T94033	Coagulation factor IIa	BCTX32	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-acetic acid	Investigative	44364101	C22H26N4O4	410.5	C1CNC[C@H]1OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BCU91A	Chembl263934	Investigative	73351805	C28H44N6O9	608.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 82000 nM	Poor binder
T94033	Coagulation factor IIa	BCVX02	(2S)-1-[(2S,3As,7aS)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]-N-[(2R)-1-[[(2S)-1-amino-3-(4-methylphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide	Investigative	57397634	C33H51N9O5	653.8	CC1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]3C[C@@H]4CCCC[C@@H]4N3C(=O)[C@H](CCCN=C(N)N)N	IC50 = 73000 nM	Poor binder
T94033	Coagulation factor IIa	BCY19A	2-(Benzylsulfonylamino)-N-[2-[(5-chlorothiophen-2-yl)methylamino]-2-oxoethyl]-4-(1-oxidopyridin-1-ium-2-yl)butanamide	Investigative	44426221	C23H25ClN4O5S2	537.1	C1=CC=C(C=C1)CS(=O)(=O)NC(CCC2=CC=CC=[N+]2[O-])C(=O)NCC(=O)NCC3=CC=C(S3)Cl	Ki = 190000 nM	Poor binder
T94033	Coagulation factor IIa	BCZ41K	Tert-butyl N-[(2S)-1-[[2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-6-[methyl-(N,N,N'-trimethylcarbamimidoyl)amino]-1-oxohexan-2-yl]carbamate	Investigative	44287527	C24H47N9O5	541.7	CC(C)(C)OC(=O)N[C@@H](CCCCN(C)C(=NC)N(C)C)C(=O)NCC(=O)NC(CCCN=C(N)N)C=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BD7FT0	US9585881, Example 86	Investigative	72550627	C30H43ClN6O5S	635.2	C[C@@H](C1CCC(CC1)C(=O)N2C[C@H](C[C@H]2C3=NC(=C(N3)Cl)C4=CC=C(C=C4)NC(=O)OC)C5CCN(CC5)S(=O)(=O)C)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BDAJ86	N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	76685067	C20H18ClN3O6S	463.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BDG79T	Pyrazinone Analog 24i	Investigative	11081488	C26H27ClN6O2	491	C1=CC=C(C=C1)CCNC2=NC(=C(N(C2=O)CC(=O)NCCCN3C=CN=C3)C4=CC=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BDOA26	1beta-[[4-(4-Amidinobenzylcarbamoyl)piperazino]carbonyloxy]-5beta-[4-[2-(4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane	Investigative	10055497	C35H55N9O6	697.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5	Ki = 111000 nM	Poor binder
T94033	Coagulation factor IIa	BDQ03E	2-[(3R)-3-Acetamido-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]-N-[(6-amino-2-methylpyridin-3-yl)methyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45267832	C22H24F3N5O5S	527.5	CC1=C(C=CC(=N1)N)CNC(=O)CN2C3=CC=CC=C3SC[C@@H](C2=O)NC(=O)C.C(=O)(C(F)(F)F)O	IC50 = 130000 nM	Poor binder
T94033	Coagulation factor IIa	BDV31L	2-(2-Chlorophenyl)-4-[5-(2,6-dimethylpiperidino)pentyl]-2H-1,4-benzoxazine-3(4H)-one	Investigative	18675103	C26H33ClN2O2	441	CC1CCCC(N1CCCCCN2C3=CC=CC=C3OC(C2=O)C4=CC=CC=C4Cl)C	IC50 = 65000 nM	Poor binder
T94033	Coagulation factor IIa	BE0JR6	2-Ketobenzothiazole 23	Investigative	3348131	C19H25N5O2S	387.5	C1CCC(C1)C(=O)NC(CCCN=C(N)N)C(=O)C2=NC3=CC=CC=C3S2	IC50 = 82000 nM	Poor binder
T94033	Coagulation factor IIa	BE47TK	Tert-butyl 4-[4-[(4-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477225	C24H29F3N4O7S	574.6	CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 103000 nM	Poor binder
T94033	Coagulation factor IIa	BE5GD3	4-Amino-N-[(2R)-2-[2-[(4-carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-oxomorpholin-4-yl]benzamide	Investigative	54587541	C21H24N6O4	424.5	C1CO[C@@H](C(=O)N1NC(=O)C2=CC=C(C=C2)N)CC(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 = 150000 nM	Poor binder
T94033	Coagulation factor IIa	BE6G7X	4'-Bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-hydroxy-1-isopropylpiperidine-4-carboxanilide	Investigative	10117556	C21H24BrClN4O3	495.8	CC(C)N1CCC(CC1)C(=O)NC2=C(C=C(C=C2O)Br)C(=O)NC3=NC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BE6QN7	1beta,5beta-Bis[4-(1-amidino-4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397380	C34H60N12O6	732.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCN(CC5)C(=N)N	Ki = 146000 nM	Poor binder
T94033	Coagulation factor IIa	BE82NW	[1-{[(2-Aminomethyl-5-chloro-benzylcarbamoyl)-methyl]-carbamoyl}-3-(1-oxy-pyridin-2-yl)-propylamino]-acetic acid	Investigative	44426236	C21H26ClN5O5	463.9	C1=CC=[N+](C(=C1)CCC(C(=O)NCC(=O)NCC2=C(C=CC(=C2)Cl)CN)NCC(=O)O)[O-]	Ki = 125000 nM	Poor binder
T94033	Coagulation factor IIa	BEJ05Y	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-[4-(piperidin-4-yloxy)-phenyl]-acetic acid	Investigative	44364302	C23H28N4O4	424.5	C1CNCCC1OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BEO67L	1beta,5beta-Bis[4-(1-amidino-4-piperidinylacetyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397341	C34H58N10O6	702.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CC5CCN(CC5)C(=N)N	Ki = 130000 nM	Poor binder
T94033	Coagulation factor IIa	BEU0S6	2-[3-(5-Carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid	Investigative	135430716	C22H17N5O5	431.4	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=CC(=C2)CC(=O)O)C3=NC4=C(N3)C=C(C=C4)C(=N)N)O	Ki ~ 150000 nM	Poor binder
T94033	Coagulation factor IIa	BEU5R3	N-[[1-[(1-Benzylpiperidin-4-yl)methyl]-3-(3-carbamimidoylphenyl)-2-oxo-1,3-diazinan-5-yl]methyl]-2-phenylacetamide	Investigative	118548776	C33H40N6O2	552.7	C1CN(CCC1CN2CC(CN(C2=O)C3=CC=CC(=C3)C(=N)N)CNC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BF35VC	(2S,4S)-4-[4-(Benzenesulfonyl)piperazin-1-yl]-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-N-phenylpyrrolidine-2-carboxamide	Investigative	72550187	C31H31ClN8O4S	647.1	C1CN(CCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC=CC=C5)S(=O)(=O)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BFD84K	CID 309369	Investigative	309369	C16H18N2O2	270.33	C1=CC=C(C=C1)OCCCOC2=CC=CC(=C2)C(=N)N	Ki = 79432.82 nM	Poor binder
T94033	Coagulation factor IIa	BFQ12Y	Ethyl 1-[4-[(5R)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	71699286	C25H29ClN4O5	501	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BFW1H8	Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	72551066	C28H39ClN8O5S	635.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 = 94000 nM	Poor binder
T94033	Coagulation factor IIa	BG2IX1	Acetic acid;(2S)-1-acetyl-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide	Investigative	137653173	C17H24N4O4	348.4	CC(=O)N1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N.CC(=O)O	Ki = 68000 nM	Poor binder
T94033	Coagulation factor IIa	BG3PZ4	Methyl 3-[4-[(6-carbamoylnaphthalene-2-carbonyl)amino]phenyl]benzoate	Investigative	57390879	C26H20N2O4	424.4	COC(=O)C1=CC=CC(=C1)C2=CC=C(C=C2)NC(=O)C3=CC4=C(C=C3)C=C(C=C4)C(=O)N	IC50 ~ 125000 nM	Poor binder
T94033	Coagulation factor IIa	BG46UQ	Chembl4218199	Investigative	145970288	C19H17NaO8S	428.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OS(=O)(=O)[O-])OCC3=CC=CC=C3)C.[Na+]	IC50 = 134000 nM	Poor binder
T94033	Coagulation factor IIa	BG6O4L	N-[[1-[(1-Benzylpiperidin-4-yl)methyl]-3-(3-carbamimidoylphenyl)-2-oxo-1,3-diazinan-5-yl]methyl]benzamide	Investigative	118548755	C32H38N6O2	538.7	C1CN(CCC1CN2CC(CN(C2=O)C3=CC=CC(=C3)C(=N)N)CNC(=O)C4=CC=CC=C4)CC5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BGBN67	3-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]propanamide;hydrochloride	Investigative	71449634	C19H25ClN4O5S	456.9	COC1=C(C=C(C=C1)CNC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	Ki = 175000 nM	Poor binder
T94033	Coagulation factor IIa	BGC1Q3	(S)-N-(3-Chlorobenzyl)-1-(3-phenylpropanoyl)pyrrolidine-2-carboxamide	Investigative	45141363	C21H23ClN2O2	370.9	C1C[C@H](N(C1)C(=O)CCC2=CC=CC=C2)C(=O)NCC3=CC(=CC=C3)Cl	Ki = 94300 nM	Poor binder
T94033	Coagulation factor IIa	BGE71W	2-N-[4-[3-(Trifluoromethyl)phenyl]phenyl]naphthalene-2,6-dicarboxamide	Investigative	57394359	C25H17F3N2O2	434.4	C1=CC(=CC(=C1)C(F)(F)F)C2=CC=C(C=C2)NC(=O)C3=CC4=C(C=C3)C=C(C=C4)C(=O)N	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BGI97R	2-(2-Hydroxy-3-ethoxyphenyl)-6-chloro-1H-benzimidazole-5-carboxamidine	Investigative	136092208	C16H15ClN4O2	330.77	CCOC1=CC=CC(=C1O)C2=NC3=C(N2)C=C(C(=C3)C(=N)N)Cl	Ki ~ 75000 nM	Poor binder
T94033	Coagulation factor IIa	BGJ6X8	3-(6-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid	Investigative	10318999	C24H25N3O3	403.5	C1CNC[C@H]1OC2=CC=C(C=C2)C(CC3=CC4=C(C=C3)C=C(C=C4)C(=N)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BGKO20	(R)-N-((2S,5S,8S,11R,12S,15S,18S,21R)-5-Benzyl-2,8-di-sec-butyl-15-(3-guanidinopropyl)-21-methoxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-10-oxa-1,4,7,14,17-pentaazabicyclo[16.3.1]docosan-12-yl)-2,3-dihydroxypropanamide	Investigative	45379634	C41H65N9O11	860	CC[C@H](C)[C@H]1C(=O)O[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H]2CC[C@H](N(C2=O)[C@H](C(=O)N([C@H](C(=O)N1)CC3=CC=CC=C3)C)[C@@H](C)CC)OC)CCCN=C(N)N)NC(=O)[C@@H](CO)O)C	IC50 = 52900 nM	Poor binder
T94033	Coagulation factor IIa	BGLK14	6-Methyl-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine	Investigative	10871563	C22H19N3O	341.4	CC1=CC2=C(C=C1C(=N)N)C=C(N2)C3=CC=CC(=C3O)C4=CC=CC=C4	Ki ~ 75000 nM	Poor binder
T94033	Coagulation factor IIa	BGM5H4	(2S)-N-(3-Imidazol-1-ylpropyl)-1-[(2R)-2-(methanesulfonamido)-3-phenylpropanoyl]pyrrolidine-2-carboxamide	Investigative	44363497	C21H29N5O4S	447.6	CS(=O)(=O)N[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)NCCCN3C=CN=C3	IC50 = 108000 nM	Poor binder
T94033	Coagulation factor IIa	BGN24E	N-{[4-(N-Aminocarbamimidoyl)phenyl]methyl}-2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]acetamide	Investigative	20802995	C24H27ClN8O2	495	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=CC=C(C=C3)/C(=N/N)/N)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BGO30M	(S)-2-{(S)-2-[(S)-2-(5-Guanidino-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10325899	C31H44N6O5	580.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCN=C(N)N	IC50 = 154000 nM	Poor binder
T94033	Coagulation factor IIa	BGO3T2	((R)-1-{(R)-1-[(6-Carbamimidoyl-pyridin-3-ylmethyl)-carbamoyl]-ethylcarbamoyl}-2-cyclohexyl-ethylamino)-acetic acid	Investigative	44411064	C21H32N6O4	432.5	C[C@H](C(=O)NCC1=CN=C(C=C1)C(=N)N)NC(=O)[C@@H](CC2CCCCC2)NCC(=O)O	IC50 = 53600 nM	Poor binder
T94033	Coagulation factor IIa	BGO57Z	1-{4-[4-Amino(imino)methylphenylcarbamoylmethyl]hexahydro-1-pyridinylcarbonyloxy}-5-[4-(2-hexahydro-4-pyridinylethylcarbamoyl)hexahydro-1-pyrazinylcarbonyloxy]cyclooctane	Investigative	44289296	C36H56N8O6	696.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCNCC3)OC(=O)N4CCC(CC4)CC(=O)NC5=CC=C(C=C5)C(=N)N	Ki = 52900 nM	Poor binder
T94033	Coagulation factor IIa	BGQ5W9	Ketothiazole inhibitor 1	Investigative	10349678	C33H38N8O5S2	690.8	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CC2=CN=CC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C3=NC=CS3)NS(=O)(=O)CC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BH02BU	Chembl4204525	Investigative	9881263	C13H11N3O2	241.24	CC1=CC=CC=C1C2=NC3=C(C=NN3C)C(=O)O2	IC50 = 129000 nM	Poor binder
T94033	Coagulation factor IIa	BH0RE4	Chembl44612	Investigative	73356338	C34H49N5O8	655.8	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 51000 nM	Poor binder
T94033	Coagulation factor IIa	BH2YE6	(-)-Trypethelone	Investigative	56598333	C16H16O4	272.29	C[C@H]1C(C2=C(O1)C3=C(C=C(C=C3C)O)C(=O)C2=O)(C)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BH53XD	CID 9937921	Investigative	9937921	C25H21ClF4N4O3S	569	CS(=O)(=O)C1=CC=CC=C1C2=CC(=C(C=C2)NC(=O)C3=CC(=NN3C4=CC=CC(=C4)CN)C(F)(F)F)F.Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BH6Y1A	Tert-butyl 3-[4-[(4-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477226	C24H29F3N4O7S	574.6	CC(C)(C)OC(=O)C1=CC(=CC=C1)NC(=O)CCCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 115000 nM	Poor binder
T94033	Coagulation factor IIa	BH7S6O	3-(({7-[Amino(imino)methyl]-2-naphthyl}methyl)-{1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}amino)-3-oxopropanoic acid	Investigative	44429108	C28H32N4O7S	568.6	COC1=CC(=C(C=C1)OC)S(=O)(=O)N2CCC(CC2)N(CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)C(=O)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BH87FV	(S)-2-{(S)-2-[(S)-2-(6-Amino-hexanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid methyl ester	Investigative	10007800	C31H44N4O5	552.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCN	IC50 = 80000 nM	Poor binder
T94033	Coagulation factor IIa	BH8D5I	(S)-N-(3-Chlorobenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide	Investigative	45141361	C20H27ClN2O2	362.9	C1CCC(C1)CCC(=O)N2CCC[C@H]2C(=O)NCC3=CC(=CC=C3)Cl	Ki = 92900 nM	Poor binder
T94033	Coagulation factor IIa	BHAG94	(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid	Investigative	137654508	C76H105N19O19S3	1685	C[C@H]1CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSC3)C(=O)N1)CCCCNC(=N)N)CC5=CC=C(C=C5)O)CC6=CC=CC=C6)CO)NC(=O)C)C(=O)O)CC(C)C)CC(=O)O)CCC(=O)N)CC7=CN=CN7	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BHCD91	N-[4-(Benzimidazol-1-yl)phenyl]-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide;2,2,2-trifluoroacetic acid	Investigative	23646231	C33H26F3N5O3S	629.7	C1=CC=C(C=C1)CC(C2=CSC3=C2C=C(C=C3)C(=N)N)C(=O)NC4=CC=C(C=C4)N5C=NC6=CC=CC=C65.C(=O)(C(F)(F)F)O	Ki ~ 63000 nM	Poor binder
T94033	Coagulation factor IIa	BHFU86	Pyrazinone Analog 24g	Investigative	11730512	C26H30ClN5O2	480	C1CNCCC1CNC(=O)CN2C(=C(N=C(C2=O)NCCC3=CC=CC=C3)Cl)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BHKT36	((S)-4-Acetimidoylamino-1-{[(1-formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-butyl)-carbamic acid tert-butyl ester	Investigative	73354766	C20H38N8O5	470.6	CC(=NCCC[C@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)OC(C)(C)C)N	IC50 = 88000 nM	Poor binder
T94033	Coagulation factor IIa	BHS98V	2-(2-Hydroxy-3-ethoxyphenyl)-6-fluoro-1H-benzimidazole-5-carboxamidine	Investigative	136092214	C16H15FN4O2	314.31	CCOC1=CC=CC(=C1O)C2=NC3=C(N2)C=C(C(=C3)C(=N)N)F	Ki ~ 75000 nM	Poor binder
T94033	Coagulation factor IIa	BI0JG6	Cyclohex-2-ene-1,2-dicarboxylic acid 1-(4-carbamimidoyl-benzylamide) 2-cyclohexylamide	Investigative	11047203	C22H30N4O2	382.5	C1CCC(CC1)NC(=O)C2=CCCCC2C(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 ~ 130000 nM	Poor binder
T94033	Coagulation factor IIa	BI4G7V	1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224854	C25H27N5O6	493.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNCC4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BI5EA7	(2s)-3-(7-Carbamimidoylnaphthalen-2-Yl)-2-[4-({(3r)-1-[(1z)-Ethanimidoyl]pyrrolidin-3-Yl}oxy)phenyl]propanoic Acid	Investigative	122129	C26H28N4O3	444.5	CC(=N)N1CC[C@@H](C1)OC2=CC=C(C=C2)[C@H](CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BI6UK7	Tert-butyl 4-[3-[(3-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477382	C23H27F3N4O7S	560.5	CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 63000 nM	Poor binder
T94033	Coagulation factor IIa	BI96WP	1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	136224847	C25H25N5O7	507.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C5=NOC(=O)N5	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BI97QF	Chembl2332610	Investigative	71716976	C64H93N17O16S3	1452.7	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](CCCCN)C(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T94033	Coagulation factor IIa	BIG2T8	2-[(3R)-3-Acetamido-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45269563	C23H24F3N5O5S	539.5	CC(=O)N[C@H]1CSC2=CC=CC=C2N(C1=O)CC(=O)NCC3=CC=C(C=C3)C(=N)N.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BIO61M	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-acetic acid ethyl ester	Investigative	44364504	C26H33N5O4	479.6	CCOC(=O)C(C1=CC=C(C=C1)O[C@H]2CCN(C2)C(=N)C)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BIY84V	2-(2-Hydroxy-biphenyl-3-yl)-3-methyl-3H-benzoimidazole-5-carboxamidine	Investigative	135535997	C21H18N4O	342.4	CN1C2=C(C=CC(=C2)C(=N)N)N=C1C3=CC=CC(=C3O)C4=CC=CC=C4	Ki = 70000 nM	Poor binder
T94033	Coagulation factor IIa	BJ0W9I	2-Ketobenzothiazole 71	Investigative	11489877	C31H39N5O3S	561.7	CN[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC(=O)C3=NC4=CC=CC=C4S3)C5CCC(CC5)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BJ1U8N	4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride	Investigative	186136	C8H11ClFNO2S	239.7	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl	IC50 = 62000 nM	Poor binder
T94033	Coagulation factor IIa	BJ30WR	2-(2,3-Dihydro-indole-1-carbonyl)-cyclopent-1-enecarboxylic acid 4-carbamimidoyl-benzylamide	Investigative	11132865	C23H24N4O2	388.5	C1CC(=C(C1)C(=O)N2CCC3=CC=CC=C32)C(=O)NCC4=CC=C(C=C4)C(=N)N	IC50 ~ 130000 nM	Poor binder
T94033	Coagulation factor IIa	BJ8Z3E	Acetic acid;(2S)-N-[(4-carbamimidoylphenyl)methyl]-1-propylpyrrolidine-2-carboxamide	Investigative	118736083	C18H28N4O3	348.4	CCCN1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N.CC(=O)O	Ki = 63000 nM	Poor binder
T94033	Coagulation factor IIa	BJ98LI	N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride	Investigative	45263389	C30H29Cl3F2N4O4	653.9	C1=CC(=CC=C1CC2=NC(=NO2)C(=O)[C@H](CCCCN)NC(=O)C3=CC(=C(C=C3)F)F)OCCC4=CC(=C(C=C4)Cl)Cl.Cl	Ki ~ 150000 nM	Poor binder
T94033	Coagulation factor IIa	BJR62Y	3-Oxo-N-phenyl-3H-benzo[f]chromene-2-carboxamide	Investigative	3123858	C20H13NO3	315.3	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=CC4=CC=CC=C43)OC2=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BJS56I	(S)-N-(3-Chlorobenzyl)-1-(2-cyclohexylacetyl)pyrrolidine-2-carboxamide	Investigative	45141360	C20H27ClN2O2	362.9	C1CCC(CC1)CC(=O)N2CCC[C@H]2C(=O)NCC3=CC(=CC=C3)Cl	Ki = 104000 nM	Poor binder
T94033	Coagulation factor IIa	BJT93B	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-3-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73348935	C24H28F3N5O7S	587.6	CCOC(=O)C1CCCN(C1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BJWP09	1-[4-[(5S)-5-[[(3-Amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	71699287	C23H25ClN4O5	472.9	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BK21ND	N-[(2R)-2-[2-[(4-Carbamimidoylphenyl)methylamino]-2-oxoethyl]-3-oxomorpholin-4-yl]benzamide	Investigative	11730366	C21H23N5O4	409.4	C1CO[C@@H](C(=O)N1NC(=O)C2=CC=CC=C2)CC(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 = 106000 nM	Poor binder
T94033	Coagulation factor IIa	BK2Z7V	2-N-[4-(3-Methoxyphenyl)phenyl]naphthalene-2,6-dicarboxamide	Investigative	57397927	C25H20N2O3	396.4	COC1=CC=CC(=C1)C2=CC=C(C=C2)NC(=O)C3=CC4=C(C=C3)C=C(C=C4)C(=O)N	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BK3BX5	2-(5-Methyl-2-hydroxyphenyl)-1H-benzimidazole-5-carboxamidine	Investigative	135443730	C15H14N4O	266.3	CC1=CC(=C(C=C1)O)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 65000 nM	Poor binder
T94033	Coagulation factor IIa	BK3U2S	Acetic acid;ethyl 1-[4-[(5S)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73348936	C28H35N5O7	553.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BK78MD	Methyl N-[4-[2-[(2S,4S)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	72550849	C27H39N9O5S	601.7	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)N5CCN(CC5)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BK7J6D	[(2S,3S)-3-[[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxymethyl]-2-bicyclo[2.2.2]oct-5-enyl]methyl 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate	Investigative	44315664	C38H52N12O6	772.9	C1CC2C=CC1[C@@H]([C@H]2COC(=O)N3CCN(CC3)C(=O)NCC4=CC=C(C=C4)N=C(N)N)COC(=O)N5CCN(CC5)C(=O)NCC6=CC=C(C=C6)N=C(N)N	Ki = 138000 nM	Poor binder
T94033	Coagulation factor IIa	BK8JL1	[(({7-[Amino(imino)methyl]-2-naphthyl}methyl){1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}amino)sulfonyl]acetic acid	Investigative	44429106	C27H32N4O8S2	604.7	COC1=CC(=C(C=C1)OC)S(=O)(=O)N2CCC(CC2)N(CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)S(=O)(=O)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BK8PY9	N-[1-{[(2-Aminomethyl-5-chloro-benzylcarbamoyl)-methyl]-carbamoyl}-3-(1-oxy-pyridin-2-yl)-propyl]-malonamic acid	Investigative	44426235	C22H26ClN5O6	491.9	C1=CC=[N+](C(=C1)CCC(C(=O)NCC(=O)NCC2=C(C=CC(=C2)Cl)CN)NC(=O)CC(=O)O)[O-]	Ki = 140000 nM	Poor binder
T94033	Coagulation factor IIa	BKDI19	Chembl364471	Investigative	73347119	C34H51N7O6	653.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BKJ09D	3-Carboxamide-coumarin deriv., 28	Investigative	24860445	C18H15NO3	293.3	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NC3=CC=CC=C3C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BKR8D4	3-Carboxamide-coumarin deriv., 4	Investigative	402501	C17H12ClNO3	313.7	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=CC(=C3)CCl)OC2=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BKZ89C	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-acetic acid	Investigative	44364486	C25H31N5O4	465.5	CC(=N)N1CCC(CC1)OC2=CC=C(C=C2)C(C(=O)O)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BL0O2Q	N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide	Investigative	127041472	C20H25N7O	379.5	CCCCNC(=O)C1=CC2=NC=C(N2C=C1)NCC3=CC=C(C=C3)N=C(N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BL2IF5	N,N-(4-Xylylidene)bisaminoguanidine	Investigative	9560223	C10H14N8	246.27	C1=CC(=CC=C1/C=N/N=C(N)N)/C=N/N=C(N)N	Ki = 68000 nM	Poor binder
T94033	Coagulation factor IIa	BL3N1W	3-N'-Naphthalen-1-ylbenzene-1,3-dicarboximidamide	Investigative	90655748	C18H16N4	288.3	C1=CC=C2C(=C1)C=CC=C2N=C(C3=CC=CC(=C3)C(=N)N)N	Ki = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BL6B1D	Chembl296659	Investigative	73356329	C29H43N7O8	617.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 109000 nM	Poor binder
T94033	Coagulation factor IIa	BL71ZP	(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-Amino-2-[(2,5-dihydroxybenzoyl)amino]hexanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]butanoic acid	Investigative	73347206	C26H41N5O8	551.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 126000 nM	Poor binder
T94033	Coagulation factor IIa	BLE6Y1	(2S)-2-[3-[2-[2-[2-[2-[5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-N-[(1S)-5-amino-1-diphenoxyphosphorylpentyl]butanediamide	Investigative	44412258	C42H64N7O12PS	922	C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)NCCOCCOCCOCCOCCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@H](CCCCN)P(=O)(OC3=CC=CC=C3)OC4=CC=CC=C4)NC(=O)N2	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BLN3X5	3-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)propanamide;hydrochloride	Investigative	71451446	C18H23ClN4O5S	442.9	COC1=C(C=C(C=C1)NC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N)OC.Cl	Ki = 187000 nM	Poor binder
T94033	Coagulation factor IIa	BLZX12	2-(Benzothiazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one	Investigative	72793747	C18H17NO4S2	375.5	CC(C)(C)C(=O)OC1=COC(=CC1=O)CSC2=NC3=CC=CC=C3S2	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BM0XI7	2-(5-Carboxybenzoxazole-2-ylthiomethyl)-5-(pivaloyloxy)-4H-pyran-4-one	Investigative	72793776	C19H17NO7S	403.4	CC(C)(C)C(=O)OC1=COC(=CC1=O)CSC2=NC3=C(O2)C=CC(=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BM2BP5	1,4-Di{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbonyl]hexahydro-1-pyrazinyl}-1,4-butanedione	Investigative	44339860	C32H34N8O6	626.7	C1CN(CCN1C(=O)CCC(=O)N2CCN(CC2)C(=O)C3=CC4=C(O3)C=CC(=C4)C(=N)N)C(=O)C5=CC6=C(O5)C=CC(=C6)C(=N)N	Ki = 51000 nM	Poor binder
T94033	Coagulation factor IIa	BM4GP8	Ethyl 1-[4-[(5R)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73347404	C24H28F3N5O7S	587.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BM6ND8	Chembl2332604	Investigative	71716975	C59H82N16O15S3	1351.6	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)CN)C(=O)NCC(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T94033	Coagulation factor IIa	BMGE05	3-Carboxamide-coumarin deriv., 33	Investigative	24860444	C17H12ClNO3	313.7	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NC3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BMH7Q6	Acetic acid;1-[4-[(5S)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	73348937	C26H33N5O6	511.6	CC(=O)O.C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNCC4=CC=C(C=C4)C(=N)N	Ki = 53000 nM	Poor binder
T94033	Coagulation factor IIa	BMLQ46	2-[(R)-3-(3-Guanidino-propyl)-2,5-dioxo-piperazin-1-yl]-N-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376700	C19H30N10O4S	494.6	C1C(=O)N[C@@H](C(=O)N1CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2)CCCN=C(N)N	IC50 = 200000 nM	Poor binder
T94033	Coagulation factor IIa	BMPW74	2-{2-[4-((S)-Pyrrolidin-3-yloxy)-phenyl]-ethyl}-benzofuran-5-carboxamidine	Investigative	11725377	C21H23N3O2	349.4	C1CNC[C@H]1OC2=CC=C(C=C2)CCC3=CC4=C(O3)C=CC(=C4)C(=N)N	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BN08XE	(2E)-2-Cyano-3-(4-hydroxyphenyl)prop-2-enamide	Investigative	5328796	C10H8N2O2	188.18	C1=CC(=CC=C1/C=C(\\C#N)/C(=O)N)O	Ki = 102000 nM	Poor binder
T94033	Coagulation factor IIa	BN15HC	2-[6-(3-Carbamimidoylphenoxy)-4-[di(propan-2-yl)amino]-3,5-difluoropyridin-2-yl]oxy-5-[(3-methoxyphenyl)methylcarbamoyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	44407815	C36H36F5N5O8	761.7	CC(C)N(C1=C(C(=NC(=C1F)OC2=C(C=C(C=C2)C(=O)NCC3=CC(=CC=C3)OC)C(=O)O)OC4=CC=CC(=C4)C(=N)N)F)C(C)C.C(=O)(C(F)(F)F)O	IC50 = 69000 nM	Poor binder
T94033	Coagulation factor IIa	BN1HJ5	Methyl N-[4-[2-[(2S,4R)-1-(4-carbamimidoylpiperazine-1-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	72550628	C27H38ClN9O5S	636.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)N4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C)Cl	IC50 = 57000 nM	Poor binder
T94033	Coagulation factor IIa	BN1SF0	1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-3-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	73353473	C22H24F3N5O7S	559.5	C1CC(CN(C1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N)C(=O)O.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BN36GW	(2S)-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S)-21-[[(2S)-2-[(2-Aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]-15-(4-aminobutyl)-9-[(2S)-butan-2-yl]-29-[3-(diaminomethylideneamino)propyl]-18-[(1R)-1-hydroxyethyl]-12-(hydroxymethyl)-2,8,11,14,17,20,28,31-octaoxo-23,24-dithia-1,7,10,13,16,19,27,30-octazatricyclo[30.3.0.03,7]pentatriacontane-26-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	Investigative	122192779	C55H93N21O15S2	1352.6	CC[C@H](C)[C@H]1C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CO)CCCCN)[C@@H](C)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CN)C(=O)N[C@@H](CC4=CN=CN4)C(=O)O)CCCN=C(N)N	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BN37YR	Cyanin	Investigative	441688	C27H31O16+	611.5	C1=CC(=C(C=C1C2=C(C=C3C(=CC(=CC3=[O+]2)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O	IC50 = 75000 nM	Poor binder
T94033	Coagulation factor IIa	BN3C2F	1beta,5beta-Bis[4-[2-(1-amidino-4-piperidinyl)ethylcarbamoyl]piperazinocarbonyloxy]cyclooctane	Investigative	18397342	C36H64N12O6	761	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCN(CC5)C(=N)N	Ki = 112000 nM	Poor binder
T94033	Coagulation factor IIa	BN4G8U	2,6-Bis-(3-carbamimidoyl-phenoxy)-nicotinic acid	Investigative	10596601	C20H17N5O4	391.4	C1=CC(=CC(=C1)OC2=NC(=C(C=C2)C(=O)O)OC3=CC=CC(=C3)C(=N)N)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BN4QR9	((R)-2-Cyclohexyl-1-{cyclopentyl-[(4-guanidinocarbonyl-phenylcarbamoyl)-methyl]-carbamoyl}-ethylamino)-acetic acid	Investigative	44346081	C26H38N6O6	530.6	C1CCC(CC1)C[C@H](C(=O)N(CC(=O)ONC2=CC=C(C=C2)C(=O)N=C(N)N)C3CCCC3)NCC(=O)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BN6AG4	Ethyl 1-[4-[(5S)-5-[[(5-chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	76311332	C23H26ClN3O5S	492	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BN85QA	{(R)-1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-3-methyl-pentylamino}-acetic acid	Investigative	44415089	C27H35N5O4	493.6	CCC(C)C[C@H](C(=O)NC1(CC2=CC=CC=C2C1)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 = 85000 nM	Poor binder
T94033	Coagulation factor IIa	BNJ5S2	(2S,4S)-N-(2H-Benzotriazol-5-yl)-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carboxamide	Investigative	72550404	C25H25ClN10O3	549	C1COCCN1[C@H]2C[C@H](N(C2)C(=O)/C=C/C3=C(C=CC(=C3)Cl)N4C=NN=N4)C(=O)NC5=CC6=NNN=C6C=C5	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BNL5R2	Methyl 3-[4-[(6-methoxynaphthalen-2-yl)sulfonylamino]phenyl]benzoate	Investigative	57325502	C25H21NO5S	447.5	COC1=CC2=C(C=C1)C=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)C4=CC(=CC=C4)C(=O)OC	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BNP02M	2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-2,5,6-trifluoro-3-hydroxyphenyl)methyl]acetamide	Investigative	136104459	C24H23ClF3N7O3	549.9	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=C(C(=C(C(=C3F)F)C(=N)N)O)F)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BNT4U5	3-Carboxamide-coumarin deriv., 20	Investigative	10423722	C17H13NO3	279.29	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BNY76B	5-Chloro-N-(((3S,3aS)-1-oxo-7-(3-oxomorpholino)-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-3-yl)methyl)thiophene-2-carboxamide	Investigative	118713026	C21H20ClN3O5S	461.9	C1CC2=C(C=CC(=C2)N3CCOCC3=O)N4[C@@H]1[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BNZK80	((R)-2-Cyclohexyl-1-{cyclopentyl-[(2-piperidin-4-yl-ethylcarbamoyl)-methyl]-carbamoyl}-ethylamino)-acetic acid	Investigative	44346150	C25H44N4O5	480.6	C1CCC(CC1)C[C@H](C(=O)N(CC(=O)ONCCC2CCNCC2)C3CCCC3)NCC(=O)O	IC50 = 74000 nM	Poor binder
T94033	Coagulation factor IIa	BO3HD9	(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	44394250	C41H57N7O6	743.9	CCCC(C(=O)C(=O)N[C@H](C)C1=CC=CC=C1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BO51NX	2-(3-{5-Amino-1H-imidazo[4,5-b]pyridin-2-yl}-4-hydroxy-5-(3-nitrophenyl)phenyl)acetic acid	Investigative	135559072	C20H15N5O5	405.4	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=CC(=C2)CC(=O)O)C3=NC4=C(N3)C=CC(=N4)N)O	Ki ~ 150000 nM	Poor binder
T94033	Coagulation factor IIa	BO5H3I	Tert-butyl 4-[[2-[(4-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477068	C22H25F3N4O7S	546.5	CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 85000 nM	Poor binder
T94033	Coagulation factor IIa	BO84MS	3-Carboxamide-coumarin deriv., 31	Investigative	24860442	C17H12ClNO3	313.7	CC1=CC2=C(C=C1)OC(=O)C(=C2)C(=O)NC3=CC=CC=C3Cl	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BOA19T	(2E)-2-Cyano-3-[4-(propan-2-yl)phenyl]-N-(tetrahydrofuran-2-ylmethyl)prop-2-enamide	Investigative	5760260	C18H22N2O2	298.4	CC(C)C1=CC=C(C=C1)/C=C(\\C#N)/C(=O)NCC2CCCO2	Ki = 165000 nM	Poor binder
T94033	Coagulation factor IIa	BOK16U	3-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477829	C19H19F3N4O7S	504.4	C1=CC(=CC(=C1)NC(=O)CCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)C(=O)O.C(=O)(C(F)(F)F)O	Ki = 88000 nM	Poor binder
T94033	Coagulation factor IIa	BOL28Z	(S)-N-((1-Carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide	Investigative	45486354	C32H55N13O4	685.9	CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC1CCN(CC1)C(=N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC2=CC=CC=C2	Ki = 50000 nM	Poor binder
T94033	Coagulation factor IIa	BOL71B	3,5-Bis-[1-(4-carbamimidoyl-phenyl)-meth-(Z)-ylidene]-4-oxo-cyclohexanecarboxylic acid	Investigative	10386378	C23H22N4O3	402.4	C1/C(=C/C2=CC=C(C=C2)C(=N)N)/C(=O)/C(=C\\C3=CC=C(C=C3)C(=N)N)/CC1C(=O)O	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BOVH95	Acetic acid;ethyl 1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73353475	C28H35N5O7	553.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BP0R9K	2-{5-[Amino(iminio)methyl]-6-chloro-1H-benzimidazol-2-YL}-6-isobutoxybenzenolate	Investigative	447486	C18H19ClN4O2	358.8	CC(C)COC1=CC=CC(=C1O)C2=NC3=C(N2)C=C(C(=C3)C(=N)N)Cl	Ki = 90000 nM	Poor binder
T94033	Coagulation factor IIa	BP23AS	3-(N-Phenylsulfamoyl)Benzamidinium Chloride	Investigative	71451444	C13H14ClN3O2S	311.79	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 160000 nM	Poor binder
T94033	Coagulation factor IIa	BP46AQ	((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-5-guanidino-pentyl)-carbamic acid tert-butyl ester	Investigative	9846259	C19H37N7O5	443.5	CC(C)(C)OC(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BP56FA	3-[1-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate	Investigative	10228659	C27H25F3N2O4	498.5	C1CN(CCC1C2=CC=CC(=C2)CN)C(=O)C3=CC=C(O3)C#CC4=CC=CC=C4.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BP9FS2	2-Ketobenzothiazole 47	Investigative	11376076	C28H37N7O2S	535.7	CN[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCN=C(N)N)CC3=NC4=CC=CC=C4S3	IC50 = 63000 nM	Poor binder
T94033	Coagulation factor IIa	BPA6H1	(-)-Cereoaldomine	Investigative	135981708	C16H15NO5	301.29	C[C@H]1C(C2=C(O1)C3=C(C(=C(C=C3C=O)O)O)C(=N)C2=O)(C)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BPE6O4	2-(2-Pyridylmethyl)-6-amidino-1H-benzoimidazole	Investigative	22628841	C14H13N5	251.29	C1=CC=NC(=C1)CC2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki ~ 150000 nM	Poor binder
T94033	Coagulation factor IIa	BPF4B3	6-Methoxy-N-[4-[3-(trifluoromethyl)phenyl]phenyl]naphthalene-2-carboxamide	Investigative	57401327	C25H18F3NO2	421.4	COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=CC(=CC=C4)C(F)(F)F	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BPMC04	2-[4-[2-Diphenoxyphosphoryl-2-(methanesulfonamido)ethyl]phenyl]guanidine	Investigative	16718760	C22H25N4O5PS	488.5	CS(=O)(=O)NC(CC1=CC=C(C=C1)N=C(N)N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3	IC50 = 125000 nM	Poor binder
T94033	Coagulation factor IIa	BPX43O	1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	73347406	C23H24F3N5O8S	587.5	CC1(CCCN(C1=O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N)C(=O)O.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BPY45M	{[2-(4-Carbamimidoyl-benzylcarbamoyl)-cyclopentanecarbonyl]-amino}-phenyl-acetic acid	Investigative	10526243	C23H26N4O4	422.5	C1C[C@H]([C@@H](C1)C(=O)N[C@H](C2=CC=CC=C2)C(=O)O)C(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 ~ 132000 nM	Poor binder
T94033	Coagulation factor IIa	BPZ17I	N-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]naphthalene-2-sulfonamide	Investigative	9543486	C20H22N2O3S	370.5	C1=CC=C(C=C1)C[C@@H]([C@@H](CNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)O)N	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BPZM04	3-Carboxamide-coumarin deriv., 45	Investigative	24860450	C17H11BrClNO3	392.6	CC1=CC(=CC=C1)NC(=O)C2=CC3=CC(=CC(=C3OC2=O)Br)Cl	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BQ3XR7	3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid methyl ester	Investigative	10318568	C19H25FN2O6	396.4	CC(C)[C@@H](C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BQ53WS	5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H-pyrazol-4-yl)-thiazol-2-yl]-thiophene-2-carboxamidine	Investigative	44333833	C20H20N6OS3	456.6	CCCOC1=C(C=NN1C2=CC=CC=N2)C3=CSC(=N3)C4=C(SC(=C4)C(=N)N)SC	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BQ6YO1	Chembl4202662	Investigative	145977247	C32H36N8O5S2	676.8	C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CN=CC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C3=NC=CS3)NS(=O)(=O)C4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BQ90LI	Sodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate	Investigative	53392251	C26H25NaO13S	600.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)OC)C.[Na+]	IC50 = 60000 nM	Poor binder
T94033	Coagulation factor IIa	BQM19O	(2S,3S,4S,5R,6S)-6-[5-Chloro-3-[(5-chloropyridin-2-yl)carbamoyl]-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid	Investigative	59432238	C31H33Cl2N5O9	690.5	CN1CCCN(CC1)C2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)Cl)C(=O)NC5=NC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BQN0C9	(E)-2-(3-Nitrophenyl)-N-[3-[[1-(pyridin-3-ylmethyl)triazol-4-yl]methoxy]phenyl]ethenesulfonamide	Investigative	56675717	C23H20N6O5S	492.5	C1=CC(=CC(=C1)[N+](=O)[O-])/C=C/S(=O)(=O)NC2=CC(=CC=C2)OCC3=CN(N=N3)CC4=CN=CC=C4	Ki = 62500 nM	Poor binder
T94033	Coagulation factor IIa	BQPV27	1-[4-[(5S)-5-[[(5-Chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-2-oxopiperidine-4-carboxylic acid	Investigative	76336676	C21H20ClN3O6S	477.9	C1CN(C(=O)CC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl	Ki = 69600 nM	Poor binder
T94033	Coagulation factor IIa	BQXK37	N-({7-[Amino(imino)methyl]-2-naphthyl}methyl)-N-{1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}acetamide	Investigative	44429104	C27H32N4O5S	524.6	CC(=O)N(CC1=CC2=C(C=C1)C=CC(=C2)C(=N)N)C3CCN(CC3)S(=O)(=O)C4=C(C=CC(=C4)OC)OC	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BQZ0H9	Palladium analogue	Investigative	49837842	C28H20N4Pd	518.9	C1=CC=C2C(=C1)C=NC3=CC=CC=C3C=NC4=CC=CC=C4C=NC5=CC=CC=C5C=N2.[Pd]	Ki = 170000 nM	Poor binder
T94033	Coagulation factor IIa	BR0NA9	{(R)-1-[6-(4-Carbamimidoyl-benzylcarbamoyl)-6,7-dihydro-5H-[2]pyrindin-6-ylcarbamoyl]-2-methyl-propylamino}-acetic acid	Investigative	11849425	C24H30N6O4	466.5	CC(C)[C@H](C(=O)NC1(CC2=C(C1)C=NC=C2)C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BR1N6I	2-[N-(Benzylsulfonyl)-D-Phe-L-Asn-L-Arg-]thiazole	Investigative	11828451	C29H36N8O6S2	656.8	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2)NS(=O)(=O)CC3=CC=CC=C3	IC50 = 60000 nM	Poor binder
T94033	Coagulation factor IIa	BR2JP5	(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	3088969	C36H53N7O6	679.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BR4GB6	4-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477685	C18H17F3N4O7S	490.4	C1=CC(=CC(=C1)S(=O)(=O)NCC(=O)NC2=CC=C(C=C2)C(=O)O)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 52000 nM	Poor binder
T94033	Coagulation factor IIa	BR5SB1	Boc-Darg-Gly-Arg-Cho	Investigative	53800364	C19H37N9O5	471.6	CC(C)(C)OC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 = 180000 nM	Poor binder
T94033	Coagulation factor IIa	BR5VK9	Sodium;[2-[[6-methoxy-3-[(2-methylpropan-2-yl)oxycarbonyl]-1-benzofuran-5-yl]oxymethyl]-1,3-benzothiazol-6-yl] sulfate	Investigative	118723894	C22H20NNaO9S2	529.5	CC(C)(C)OC(=O)C1=COC2=CC(=C(C=C21)OCC3=NC4=C(S3)C=C(C=C4)OS(=O)(=O)[O-])OC.[Na+]	IC50 = 146000 nM	Poor binder
T94033	Coagulation factor IIa	BR72MI	(S)-3-{4-[(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-ethoxycarbonyl-methyl]-phenoxy}-pyrrolidine-1-carboxylic acid allyl ester	Investigative	44364123	C28H34N4O6	522.6	CCOC(=O)C(C1=CC=C(C=C1)O[C@H]2CCN(C2)C(=O)OCC=C)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BR7N9G	Chembl184525	Investigative	73350210	C33H49N7O7	655.8	CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2C3CCCC3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H]([C@@H](C)OC)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BREZ58	[4-[2-(5-Carbamimidoyl-2-hydroxybenzenesulfonylamino)-ethyl]-2'-methanesulfonoylbiphenyl-3-yloxy]acetic acid hydrochloride	Investigative	135456120	C24H26ClN3O8S2	584.1	CS(=O)(=O)C1=CC=CC=C1C2=CC(=C(C=C2)CCNS(=O)(=O)C3=C(C=CC(=C3)C(=N)N)O)OCC(=O)O.Cl	Ki = 57800 nM	Poor binder
T94033	Coagulation factor IIa	BRF3Q7	7-({[1-(2,5-Dimethoxy-benzenesulfonyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine	Investigative	44429102	C26H32N4O6S2	560.7	COC1=CC(=C(C=C1)OC)S(=O)(=O)N2CCC(CC2)N(CC3=CC4=C(C=C3)C=CC(=C4)C(=N)N)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BRI7J1	3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine	Investigative	44324727	C20H25N5O	351.4	C1CN(CCC1NC(=O)NC2=CC=CC(=C2)C(=N)N)CC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BRW97H	[2'-Hydroxy-3'-(1H-pyrrolo[3,2-c]pyridin-2-yl)-biphenyl-3-ylmethyl]-urea	Investigative	15942655	C21H18N4O2	358.4	C1=CC(=CC(=C1)C2=C(C(=CC=C2)C3=CC4=C(N3)C=CN=C4)O)CNC(=O)N	Ki = 71500 nM	Poor binder
T94033	Coagulation factor IIa	BS0HG7	Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-2-carboxylate;2,2,2-trifluoroacetic acid	Investigative	73353474	C24H28F3N5O7S	587.6	CCOC(=O)C1CCCCN1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BS0XJ8	N-[1-(1-Amino-isoquinolin-6-ylmethyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide	Investigative	44374707	C29H31N5O4S	545.7	C1CCN(CC1)C(=O)C(CC2=CC3=C(C=C2)C(=NC=C3)N)NC(=O)CNS(=O)(=O)C4=CC5=CC=CC=C5C=C4	IC50 = 55000 nM	Poor binder
T94033	Coagulation factor IIa	BS2IR5	1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetic acid	Investigative	73356533	C22H24F3N5O7S	559.5	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CN=C(S4)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BS4YI2	(3E,9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-7,7-dioxo-7lambda6-thia-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),3,17(22),18,20-pentaene-10,13-dione	Investigative	52941173	C28H39ClN4O4S	563.2	CC(C)C[C@H]1C(=O)NCC2=C(C/C=C/CCS(=O)(=O)N[C@@H](C(=O)N1)C3CCCCC3)NC4=C2C=C(C=C4)Cl	IC50 = 67900 nM	Poor binder
T94033	Coagulation factor IIa	BS5A8E	3-[3-[(1-Benzylpiperidin-4-yl)methyl]-5-methoxy-2-oxo-1,3-diazinan-1-yl]benzenecarboximidamide	Investigative	118548759	C25H33N5O2	435.6	COC1CN(C(=O)N(C1)C2=CC=CC(=C2)C(=N)N)CC3CCN(CC3)CC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BS86FA	2-[(3R)-3-Amino-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45272949	C21H22F3N5O4S	497.5	C1[C@@H](C(=O)N(C2=CC=CC=C2S1)CC(=O)NCC3=CC=C(C=C3)C(=N)N)N.C(=O)(C(F)(F)F)O	IC50 = 87000 nM	Poor binder
T94033	Coagulation factor IIa	BS9F1N	7-Hydroxy-2-oxo-N-phenyl-2H-1-benzopyran-3-carboxamide	Investigative	5400404	C16H11NO4	281.26	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=C(C=C3)O)OC2=O	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BSCM59	6-[N-(4-(Aminomethyl)phenyl)carbamyl]-2-naphthalenecarboxamidine	Investigative	447733	C19H18N4O	318.4	C1=CC(=CC=C1CN)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)C(=N)N	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BSLX01	Chembl4208441	Investigative	145964676	C20H19NaO8S	442.4	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OCC3=CC(=CC=C3)S(=O)(=O)[O-])OC)C.[Na+]	IC50 = 134000 nM	Poor binder
T94033	Coagulation factor IIa	BSM24W	Chembl4214557	Investigative	145972739	C18H15NaO8S	414.4	CC1=C(C2=CC(=C(C=C2O1)OC)OS(=O)(=O)[O-])C(=O)OCC3=CC=CC=C3.[Na+]	IC50 = 168000 nM	Poor binder
T94033	Coagulation factor IIa	BSR61T	1,3-Di{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbonyl]hexahydro-1-pyrazinyl}-1,3-propanedione	Investigative	44340114	C31H32N8O6	612.6	C1CN(CCN1C(=O)CC(=O)N2CCN(CC2)C(=O)C3=CC4=C(O3)C=CC(=C4)C(=N)N)C(=O)C5=CC6=C(O5)C=CC(=C6)C(=N)N	Ki = 82000 nM	Poor binder
T94033	Coagulation factor IIa	BSR9A3	2-[(S)-3-(3-Guanidino-propyl)-2-oxo-piperazin-1-yl]-N-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide	Investigative	44376514	C19H32N10O3S	480.6	C1CN(C(=O)[C@@H](N1)CCCN=C(N)N)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2	IC50 = 150000 nM	Poor binder
T94033	Coagulation factor IIa	BT0AJ5	2,2'-(1,2-Phenylene)bis[oxy(1-oxoethane-2,1-diyl)(piperazine-4,1-diyl)carbonyl]bis(benzofuran-5-carboxamidine)	Investigative	44340005	C38H38N8O8	734.8	C1CN(CCN1C(=O)COC2=CC=CC=C2OCC(=O)N3CCN(CC3)C(=O)C4=CC5=C(O4)C=CC(=C5)C(=N)N)C(=O)C6=CC7=C(O6)C=CC(=C7)C(=N)N	Ki = 88000 nM	Poor binder
T94033	Coagulation factor IIa	BT16FW	{[2-(4-Carbamimidoyl-benzylcarbamoyl)-cyclopent-1-enecarbonyl]-o-tolyl-amino}-acetic acid	Investigative	11080573	C24H26N4O4	434.5	CC1=CC=CC=C1N(CC(=O)O)C(=O)C2=C(CCC2)C(=O)NCC3=CC=C(C=C3)C(=N)N	IC50 = 120000 nM	Poor binder
T94033	Coagulation factor IIa	BT2AE4	4-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)butanamide;hydrochloride	Investigative	71453264	C19H25ClN4O5S	456.9	COC1=C(C=C(C=C1)NC(=O)CCCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)OC.Cl	Ki = 83000 nM	Poor binder
T94033	Coagulation factor IIa	BT47LV	N-[(3-Bromophenyl)methyl]-2-[(4-carbamimidoylphenyl)carbamoylamino]acetamide	Investigative	11188883	C17H18BrN5O2	404.3	C1=CC(=CC(=C1)Br)CNC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BT8J6P	N-((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-guanidino-butyl)-malonamic acid	Investigative	73345684	C17H31N9O6	457.5	C(C[C@@H](C=O)NC(=O)CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)CC(=O)O)CN=C(N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BT9V1X	6-Methoxy-N-[4-(3-nitrophenyl)phenyl]naphthalene-2-carboxamide	Investigative	57390825	C24H18N2O4	398.4	COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=CC(=CC=C4)[N+](=O)[O-]	IC50 ~ 62000 nM	Poor binder
T94033	Coagulation factor IIa	BTES06	6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-2-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine	Investigative	136092216	C19H20FN5O2	369.4	C1C[C@@H](NC1)COC2=CC=CC(=C2O)C3=NC4=C(N3)C=C(C(=C4)C(=N)N)F	Ki = 70000 nM	Poor binder
T94033	Coagulation factor IIa	BTJW14	(2S)-N-[2-(1H-Imidazol-5-yl)ethyl]-1-[(2R)-2-(methanesulfonamido)-3-phenylpropanoyl]pyrrolidine-2-carboxamide	Investigative	44363753	C20H27N5O4S	433.5	CS(=O)(=O)N[C@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)NCCC3=CN=CN3	IC50 = 134000 nM	Poor binder
T94033	Coagulation factor IIa	BTO43X	1-[4-[(5R)-5-[[(3-Amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	71699288	C23H25ClN4O5	472.9	C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC(=C(C=C4)Cl)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BTU1E6	Benzyl (3S,3aS,6aS)-1-(2-acetyloxyacetyl)-3-methyl-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]pyrrole-4-carboxylate	Investigative	44359057	C20H23NO6	373.4	C[C@H]1[C@@H]2[C@H](CCC2C(=O)OCC3=CC=CC=C3)N(C1=O)C(=O)COC(=O)C	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BU4ES9	2-Ketobenzothiazole 24	Investigative	23646592	C18H24N6O2S	388.5	C1C[C@H](NC1)C(=O)NC(CCCN=C(N)N)C(=O)C2=NC3=CC=CC=C3S2	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BU7O8G	Acetic acid;ethyl 1-[4-[(5S)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate	Investigative	73350497	C28H37N5O6	539.6	CCOC(=O)C1CCN(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNCC4=CC=C(C=C4)C(=N)N.CC(=O)O	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BUCM18	Methyl N-[4-[2-[(2S,4S)-1-(4-carbamimidoylcyclohexanecarbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate	Investigative	129012579	C28H39ClN8O5S	635.2	COC(=O)NC1=CC=C(C=C1)C2=C(NC(=N2)[C@@H]3C[C@@H](CN3C(=O)C4CCC(CC4)C(=N)N)N5CCN(CC5)S(=O)(=O)C)Cl	IC50 = 84000 nM	Poor binder
T94033	Coagulation factor IIa	BUNA43	(2S)-2-[(D-Arg-Gly-)Amino]-5-guanidinopentanal	Investigative	53864431	C14H29N9O3	371.44	C(C[C@@H](C=O)NC(=O)CNC(=O)[C@@H](CCCN=C(N)N)N)CN=C(N)N	IC50 = 55000 nM	Poor binder
T94033	Coagulation factor IIa	BUVP68	Chembl4162159	Investigative	145959466	C63H96N18O18S2	1457.7	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N3CCC[C@H]3C(=O)N4CCC[C@H]4C(=O)N1)CO)CCCCN)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]5CCCN5C(=O)[C@@H](NC2=O)CC6=CC=CC=C6)CC(=O)O)CCCN=C(N)N	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BUYW64	(2R)-5-(Diaminomethylideneamino)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-(3-phenylpropanoylamino)pentanamide	Investigative	54507330	C23H37N9O4	503.6	C1=CC=C(C=C1)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C=O	IC50 = 75000 nM	Poor binder
T94033	Coagulation factor IIa	BV15DG	Acetic acid;1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	73356537	C26H31N5O7	525.6	CC(=O)O.C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BV2GX4	(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	Investigative	10461790	C33H49N7O6	639.8	CCCC(C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)C)NC(=O)C4=NC=CN=C4	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BV2K9G	Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate	Investigative	72550407	C28H40N8O5S	600.7	COC(=O)NC1=CC=C(C=C1)C2=CN=C(N2)[C@@H]3C[C@@H](CN3C(=O)C4CCN(CC4)C(=N)N)C5CCN(CC5)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BV6WI5	(-)-Cereolactam	Investigative	56598201	C17H17NO4	299.32	C[C@H]1C(C2=C(O1)C3=C4C(=C(C=C3C)O)C(=O)NC4=C2O)(C)C	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BV8HN1	N-((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-guanidino-butyl)-succinamic acid	Investigative	73345685	C18H33N9O6	471.5	C(C[C@@H](C=O)NC(=O)CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)CCC(=O)O)CN=C(N)N	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BV8M7U	Acetic acid;(2S)-1-butyl-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide	Investigative	118736085	C19H30N4O3	362.5	CCCCN1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N.CC(=O)O	Ki = 54000 nM	Poor binder
T94033	Coagulation factor IIa	BV9FE3	3-Carboxamide-coumarin deriv., 47	Investigative	24860441	C17H12BrNO4	374.2	COC1=C2C(=CC(=C1)Br)C=C(C(=O)O2)C(=O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BVC8S1	N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3,3a,4,5-tetrahydro-[1,3]oxazolo[3,4-a]quinoxalin-3-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	118713029	C20H19ClN4O5S	462.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CN3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BVEA79	(S)-N-(3-Chlorobenzyl)-1-(2-cyclopentylacetyl)pyrrolidine-2-carboxamide	Investigative	45141359	C19H25ClN2O2	348.9	C1CCC(C1)CC(=O)N2CCC[C@H]2C(=O)NCC3=CC(=CC=C3)Cl	Ki = 72400 nM	Poor binder
T94033	Coagulation factor IIa	BVF61B	N-[(6-Amino-2-methylpyridin-3-yl)methyl]-2-[(3R)-3-amino-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]acetamide;2,2,2-trifluoroacetic acid	Investigative	45272960	C20H22F3N5O4S	485.5	CC1=C(C=CC(=N1)N)CNC(=O)CN2C3=CC=CC=C3SC[C@@H](C2=O)N.C(=O)(C(F)(F)F)O	IC50 = 88000 nM	Poor binder
T94033	Coagulation factor IIa	BVJ82M	Chembl416824	Investigative	73354799	C34H46N6O8	666.8	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCCCN)NC(=O)C3=C(C=CC(=C3)O)O	IC50 = 169000 nM	Poor binder
T94033	Coagulation factor IIa	BVZY42	3-Methylbenzenesulfonic acid 3-[4-(aminomethyl)phenethyloxy]phenyl ester	Investigative	10905375	C22H23NO4S	397.5	CC1=CC(=CC=C1)S(=O)(=O)OC2=CC=CC(=C2)OCCC3=CC=C(C=C3)CN	IC50 = 58884.37 nM	Poor binder
T94033	Coagulation factor IIa	BW17DK	{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester	Investigative	44337899	C24H38N6O4	474.6	CC(C)(C)OC(=O)N[C@@H](CN1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O)C2=CC=CC=C2	IC50 = 78000 nM	Poor binder
T94033	Coagulation factor IIa	BW45QA	N-((S)-1-{[(1-Formyl-4-guanidino-butylcarbamoyl)-methyl]-carbamoyl}-4-guanidino-butyl)-oxalamic acid	Investigative	53954748	C16H29N9O6	443.46	C(C[C@@H](C=O)NC(=O)CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(=O)O)CN=C(N)N	IC50 = 95000 nM	Poor binder
T94033	Coagulation factor IIa	BW69SC	4-[3-[2-Oxo-2-[1-[2,4-bis(trifluoromethyl)phenyl]ethylamino]ethyl]ureido]benzamidine	Investigative	44282153	C20H19F6N5O2	475.4	CC(C1=C(C=C(C=C1)C(F)(F)F)C(F)(F)F)NC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BW92QA	Chembl44548	Investigative	73347211	C29H48N6O8	608.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 68000 nM	Poor binder
T94033	Coagulation factor IIa	BW9GC3	Ethyl 1-[4-[(5S)-5-[[(5-chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-3-carboxylate	Investigative	76325821	C23H26ClN3O5S	492	CCOC(=O)C1CCCN(C1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BW9RJ8	2-[3-(4-Carbamimidoyl-phenyl)-ureido]-N-((R)-1-phenyl-ethyl)-acetamide	Investigative	44283195	C18H21N5O2	339.4	C[C@H](C1=CC=CC=C1)NC(=O)CNC(=O)NC2=CC=C(C=C2)C(=N)N	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BW9VJ2	Sodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-5-methoxy-2-methyl-1-benzofuran-6-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate	Investigative	53391547	C26H25NaO13S	600.5	CCOC(=O)C1=C(OC2=CC(=C(C=C21)OC)OCC3=C(C4=CC(=C(C=C4O3)OC)OS(=O)(=O)[O-])C(=O)OCC)C.[Na+]	IC50 = 89000 nM	Poor binder
T94033	Coagulation factor IIa	BWA83N	Tert-butyl 4-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477223	C23H27F3N4O7S	560.5	CC(C)(C)OC(=O)C1=CC=C(C=C1)NC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 174000 nM	Poor binder
T94033	Coagulation factor IIa	BWCN26	(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid	Investigative	137639385	C114H161N29O28S3	2481.9	CC[C@H](C)[C@H]1C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC4C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSC3)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N[C@H](C(=O)N1)CC(=O)O)CC6=CC=C(C=C6)O)CC7=CC=C(C=C7)O)C(C)C)CCCCNC(=N)N)CC8=CC=C(C=C8)O)CC9=CC=CC=C9)CO)NC(=O)C)C(=O)N[C@@H](C)C(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BWF0I1	2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyryl}-benzooxazole-5-carboxylic acid amide	Investigative	9962331	C37H39ClN6O9S	779.3	CC(C)[C@@H](C(=O)C1=NC2=C(O1)C=CC(=C2)C(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)C4=CC=C(C=C4)C(=O)NS(=O)(=O)C5=CC=C(C=C5)Cl	Ki ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BWT6S1	2-Pyridin-2-yl-1H-benzimidazole-6-carboximidamide	Investigative	10037159	C13H11N5	237.26	C1=CC=NC(=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 60000 nM	Poor binder
T94033	Coagulation factor IIa	BWU8Q1	3-[3-(3-Benzyl-5-carbamoyl-1H-indol-2-yl)-5-bromo-4-hydroxy-phenyl]-propionic acid	Investigative	44296052	C25H21BrN2O4	493.3	C1=CC=C(C=C1)CC2=C(NC3=C2C=C(C=C3)C(=O)N)C4=C(C(=CC(=C4)CCC(=O)O)Br)O	Ki = 78000 nM	Poor binder
T94033	Coagulation factor IIa	BWV7S6	1beta,5beta-Bis[4-(4-amidinobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397352	C36H50N10O6	718.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)C(=N)N	Ki = 59500 nM	Poor binder
T94033	Coagulation factor IIa	BX26EM	Ethyl {(1S)-5-amino-1-[(5-{4-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]benzyl}-1,2,4-oxadiazol-3-YL)carbonyl]pentyl}carbamate	Investigative	6857707	C28H33N5O5	519.6	CCOC(=O)N[C@@H](CCCCN)C(=O)C1=NOC(=N1)CC2=CC=C(C=C2)C(=O)NC3CC4=CC=CC=C4C3	Ki = 60000 nM	Poor binder
T94033	Coagulation factor IIa	BX62WV	(S)-3-Cyano-N-[(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-2-((R)-3-phenyl-2-phenylmethanesulfonylamino-propionylamino)-propionamide	Investigative	10875960	C29H34N8O5S2	638.8	C1=CC=C(C=C1)C[C@H](C(=O)N[C@@H](CC#N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC=CS2)NS(=O)(=O)CC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BX7RL5	N-[(2R)-1-[4-(2-Hydroxyethyl)piperidin-1-yl]-1-oxo-3-pyridin-4-ylpropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide	Investigative	57393205	C26H36N4O4S	500.7	CC1(CC2=C(C(=CC=C2)S(=O)(=O)N[C@H](CC3=CC=NC=C3)C(=O)N4CCC(CC4)CCO)NC1)C	Ki = 132700 nM	Poor binder
T94033	Coagulation factor IIa	BX9WA8	Darexaban	Investigative	9912771	C27H30N4O4	474.6	CN1CCCN(CC1)C2=CC=C(C=C2)C(=O)NC3=C(C=CC=C3O)NC(=O)C4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BXES30	3-(((E)-3-{3-[Amino(imino)methyl]phenyl}prop-2-en-1-yl){1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}-amino)-3-oxopropanoic acid	Investigative	44429110	C26H32N4O7S	544.6	COC1=CC(=C(C=C1)OC)S(=O)(=O)N2CCC(CC2)N(C/C=C/C3=CC(=CC=C3)C(=N)N)C(=O)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BXKH03	(2S)-5-(Diaminomethylideneamino)-N-[2-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-[(2-naphthalen-2-yloxyacetyl)amino]pentanamide	Investigative	44287610	C26H37N9O5	555.6	C1=CC=C2C=C(C=CC2=C1)OCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)NC(CCCN=C(N)N)C=O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BXNG21	Boc-D-Ser-Gly-(4-Amidinobenzyl)NH2	Investigative	44372738	C18H27N5O5	393.4	CC(C)(C)OC(=O)N[C@H](CO)C(=O)NCC(=O)NCC1=CC=C(C=C1)C(=N)N	Ki = 170000 nM	Poor binder
T94033	Coagulation factor IIa	BXOI96	[(R)-1-({[3-(5-Amino-2H-[1,2,4]triazol-3-yl)-propylcarbamoyl]-methyl}-cyclopentyl-carbamoyl)-2-cyclohexyl-ethylamino]-acetic acid	Investigative	44346161	C23H39N7O5	493.6	C1CCC(CC1)C[C@H](C(=O)N(CC(=O)ONCCCC2=NC(=NN2)N)C3CCCC3)NCC(=O)O	IC50 = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BXP80N	[(R)-2-Cyclohexyl-1-(cyclopentyl-{[(piperidin-4-ylmethyl)-carbamoyl]-methyl}-carbamoyl)-ethylamino]-acetic acid	Investigative	44346165	C24H42N4O5	466.6	C1CCC(CC1)C[C@H](C(=O)N(CC(=O)ONCC2CCNCC2)C3CCCC3)NCC(=O)O	IC50 = 133000 nM	Poor binder
T94033	Coagulation factor IIa	BXR48B	2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-2,3,5,6-tetrafluorophenyl)methyl]acetamide	Investigative	44426660	C24H22ClF4N7O2	551.9	C1CC(C1)NC2=NC(=C(N(C2=O)CC(=O)NCC3=C(C(=C(C(=C3F)F)C(=N)N)F)F)C4=CC(=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BXVU43	(2-Carbamimidoyl-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-acetic acid ethyl ester	Investigative	44364505	C24H30N4O4	438.5	CCOC(=O)C(C1=CC=C(C=C1)O[C@H]2CCNC2)OC3=CC4=C(CCN(C4)C(=N)N)C=C3	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BY3N7T	Sodium;[6-ethoxy-3-ethoxycarbonyl-2-[(6-ethoxy-3-ethoxycarbonyl-2-methyl-1-benzofuran-5-yl)oxymethyl]-1-benzofuran-5-yl] sulfate	Investigative	53392340	C28H29NaO13S	628.6	CCOC1=C(C=C2C(=C1)OC(=C2C(=O)OCC)C)OCC3=C(C4=CC(=C(C=C4O3)OCC)OS(=O)(=O)[O-])C(=O)OCC.[Na+]	IC50 = 120226.44 nM	Poor binder
T94033	Coagulation factor IIa	BY3ST6	[(((E)-3-{3-[Amino(imino)methyl]phenyl}prop-2-en-1-yl){1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}-amino)sulfonyl]acetic acid	Investigative	44429109	C25H32N4O8S2	580.7	COC1=CC(=C(C=C1)OC)S(=O)(=O)N2CCC(CC2)N(C/C=C/C3=CC(=CC=C3)C(=N)N)S(=O)(=O)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BY6SV1	3-[4-[(3-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	71477831	C20H21F3N4O7S	518.5	C1=CC(=CC(=C1)NC(=O)CCCNS(=O)(=O)C2=CC=CC(=C2)C(=N)N)C(=O)O.C(=O)(C(F)(F)F)O	Ki = 75000 nM	Poor binder
T94033	Coagulation factor IIa	BYI08W	Tert-butyl 3-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	Investigative	71477224	C23H27F3N4O7S	560.5	CC(C)(C)OC(=O)C1=CC(=CC=C1)NC(=O)CCNS(=O)(=O)C2=CC=C(C=C2)C(=N)N.C(=O)(C(F)(F)F)O	Ki = 100000 nM	Poor binder
T94033	Coagulation factor IIa	BYM16A	Chembl296313	Investigative	73345710	C31H43N5O8	613.7	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](C)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C2=C(C=CC(=C2)O)O	IC50 = 54000 nM	Poor binder
T94033	Coagulation factor IIa	BYN73G	Chembl45061	Investigative	73348722	C29H47N5O8	593.7	CC[C@H](C)[C@@H](C(=O)NCCCCCC(=O)N[C@@H](CC)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)C1=C(C=CC(=C1)O)O	IC50 = 168000 nM	Poor binder
T94033	Coagulation factor IIa	BYO4I1	Ethyl 1-[4-[(5S)-5-[[(5-chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-2-oxopiperidine-4-carboxylate	Investigative	76322205	C23H24ClN3O6S	506	CCOC(=O)C1CCN(C(=O)C1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BYPN82	Acetic acid;1-[4-[(5S)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid	Investigative	73350498	C26H31N5O7	525.6	CC(=O)O.C1CN(CCC1C(=O)O)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(C=C4)C(=N)N	Ki ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BYSM86	7-Methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide	Investigative	3162843	C17H13NO4	295.29	COC1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)NC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T94033	Coagulation factor IIa	BZ24RN	(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide	Investigative	46228924	C38H53N5O9S	755.9	CC1(CCCCC2=C3CN(CC3=CC=C2)C(=O)O[C@@H]4C[C@H](N(C4)C(=O)[C@@H](NC(=O)OC1)C(C)(C)C)C(=O)N[C@@]5(C[C@H]5C=C)C(=O)NS(=O)(=O)C6CC6)C	IC50 ~ 100000 nM	Poor binder
T94033	Coagulation factor IIa	BZ42FM	(S)-5-Guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide	Investigative	45486346	C30H53N13O4	659.8	CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC1=CC=CC=C1	Ki = 102000 nM	Poor binder
T94033	Coagulation factor IIa	BZ90KF	3-(N-Benzylsulfamoyl)Benzamidinium Chloride	Investigative	71453259	C14H16ClN3O2S	325.8	C1=CC=C(C=C1)CNS(=O)(=O)C2=CC=CC(=C2)C(=N)N.Cl	Ki = 102000 nM	Poor binder
T94033	Coagulation factor IIa	BZ9N2C	N-[(5-Amino-1-dihydroxyboranyl-pentylcarbamoyl)-methyl]-3-phenyl-propionamide	Investigative	44330409	C16H26BN3O4	335.2	B([C@H](CCCCN)NC(=O)CNC(=O)CCC1=CC=CC=C1)(O)O	IC50 = 90000 nM	Poor binder
T94033	Coagulation factor IIa	BZS57E	Acetic acid;(2S)-N-[(4-carbamimidoylphenyl)methyl]-1-methylsulfonylpyrrolidine-2-carboxamide	Investigative	137635035	C16H24N4O5S	384.5	CC(=O)O.CS(=O)(=O)N1CCC[C@H]1C(=O)NCC2=CC=C(C=C2)C(=N)N	Ki = 68000 nM	Poor binder
T94033	Coagulation factor IIa	D0A8WP	6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine	Investigative	447732	C18H15N3O	289.3	C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)C(=N)N	IC50 = 56000 nM	Poor binder
T94033	Coagulation factor IIa	D0M1LO	Piperidine-1-carboxamidine	Investigative	205051	C6H13N3	127.19	C1CCN(CC1)C(=N)N	Ki = 111000 nM	Poor binder
T94033	Coagulation factor IIa	D0V7AA	CATECHIN	Investigative	9064	C15H14O6	290.27	C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O	IC50 = 125000 nM	Poor binder