TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99089	Serine/threonine-protein kinase B-raf	D0AZ3C	Imatinib	Approved	5291	C29H31N7O	493.6	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	D0J9ZR	Niclosamide	Approved	4477	C13H8Cl2N2O4	327.12	C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B05NYL	1-[1-(2-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperidine-4-carboxamide	Investigative	2855606	C17H21N3O4	331.4	COC1=CC=CC=C1N2C(=O)CC(C2=O)N3CCC(CC3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B05WIZ	CID 44133365	Investigative	44133365	C21H12F5N5O3	477.3	C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=C(C=C2)OC3=C4C(=NC=C3)N=CC(=O)N4)F)F	IC50 = 69000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B0A9MD	1-(Thiophen-2-yl)-2-(4H-[1,2,4]triazolo[1,5-a]benzimidazol-4-yl)ethanone	Investigative	777751	C14H10N4OS	282.32	C1=CC=C2C(=C1)N(C3=NC=NN23)CC(=O)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B0VK4S	N-(2,6-Dimethylphenyl)-2-{[4-methyl-5-(4-morpholinylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide	Investigative	1088625	C18H25N5O2S	375.5	CC1=C(C(=CC=C1)C)NC(=O)CSC2=NN=C(N2C)CN3CCOCC3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B13UPZ	2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone	Investigative	42603880	C15H12N6O	292.3	C1=CC=C2C(=C1)C(=CN2)C(=O)CN3C=NC4=C(N=CN=C43)N	IC50 = 82000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B18LHC	3-Chloro-2-fluoro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-5-(trifluoromethyl)benzenesulfonamide	Investigative	46228527	C20H12ClF4N3O4S	501.8	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NS(=O)(=O)C4=C(C(=CC(=C4)C(F)(F)F)Cl)F	IC50 = 65000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B18UTD	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3,4-dihydro-2H-1,5-benzodioxepine-6-carboxamide	Investigative	46228694	C23H19N3O5	417.4	C1COC2=CC=CC(=C2OC1)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B1BUI0	6-(2,2-Dimethoxyethylsulfamoyl)-9H-pyrido[3,4-b]indole-1-carboxamide	Investigative	53380320	C16H18N4O5S	378.4	COC(CNS(=O)(=O)C1=CC2=C(C=C1)NC3=C2C=CN=C3C(=O)N)OC	IC50 = 91550 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B1F3NC	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide	Investigative	46228903	C20H15N3O3	345.4	C1=CC=C(C=C1)C(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B1O8MF	Pyridoimidazolone, 5g	Investigative	42626195	C20H14F3N5O3	429.4	C1=CC(=CC=C1C(F)(F)F)NC(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B23JES	N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide	Investigative	46228820	C20H14F3N3O4S	449.4	C1=CC(=CC(=C1)S(=O)(=O)NC2=CC=C(C=C2)OC3=CC=CC4=C3NC(=O)N4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B2GK6Z	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1,3-dihydro-2,1,3-benzothiadiazole-5-carboxamide	Investigative	46228696	C20H15N5O3S	405.4	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NC(=O)C4=CC5=C(C=C4)NSN5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B2KY9Q	2-(Phenyl-N-methylamino)-6-(3-acetamidophenyl)pyrazine	Investigative	44406731	C19H19N5O	333.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NN(C)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B2NT4A	2-(3,4,5-Trimethoxyphenylamino)-3-acetamido-6-(3-acetamidophenyl)pyrazine	Investigative	11583265	C23H25N5O5	451.5	CC(=O)NC1=CC=CC(=C1)C2=CN=C(C(=N2)NC3=CC(=C(C(=C3)OC)OC)OC)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B2ZG1W	1-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(3-(2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea	Investigative	44133910	C21H13F4N5O3	459.4	C1=CC(=CC(=C1)OC2=C3C(=NC=C2)N=CC(=O)N3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B2ZJK3	5-Pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine	Investigative	56950878	C14H9Cl3N4	339.6	C1=CN=CC=C1C2=NN(C(=C2)N)C3=C(C=C(C=C3Cl)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B35HMZ	1-{2-[5-(2-Furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl}-4-methylpiperazine	Investigative	11841124	C18H22N4O2S	358.5	CN1CCN(CC1)CC(=O)N2C(CC(=N2)C3=CC=CS3)C4=CC=CO4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B36RWG	4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]benzamide	Investigative	49863687	C29H36N4O3	488.6	CN1CCN(CC1)CC2=CC=C(C=C2)C(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B3HE8Y	N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]-2-[3-(trifluoromethyl)phenyl]acetamide	Investigative	44186417	C25H17F3N4O3	478.4	C1=CC=C2C(=C1)C(=CC=C2OC3=C4C(=NC=C3)NC(=O)N4)NC(=O)CC5=CC(=CC=C5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B3MTX1	2-Benzyl-5-tert-butyl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyrazole-3-carboxamide	Investigative	46228731	C28H27N5O3	481.5	CC(C)(C)C1=NN(C(=C1)C(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4)CC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B3U6WP	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-phenylpyrazole-3-carboxamide	Investigative	46228730	C23H17N5O3	411.4	C1=CC=C(C=C1)N2C(=CC=N2)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5	IC50 = 92000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B41IJN	5-[4-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]phenyl]-1H-pyrazole-4-carbonitrile	Investigative	52943666	C28H25N7O	475.5	CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)C5=C(C=NN5)C#N	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B47HXI	5-({6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}oxy)-2,3-dihydro-1H-inden-1-one	Investigative	24879261	C22H21N3O5	407.4	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC4=C(C=C3)C(=O)CC4	IC50 = 70000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B4DP2E	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-1,2-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea	Investigative	44133546	C21H13ClF3N5O3	475.8	C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=C4C(=NC=C3)N=CC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B4I3EY	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide	Investigative	46228819	C20H14F3N3O4S	449.4	C1=CC(=CC(=C1)S(=O)(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4)C(F)(F)F	IC50 = 57000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B4P8MW	Pyridoimidazolone, 29c	Investigative	42625326	C18H13ClN4O4S	416.8	C1=CC(=CC=C1NS(=O)(=O)C2=CC=C(C=C2)Cl)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B4T2QU	N-Methyl-4-(4-(4-((4-methylpiperazin-1-yl)methyl)benzamido)phenoxy)picolinamide	Investigative	49863686	C26H29N5O3	459.5	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)CN4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B56WLV	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-benzothiophene-5-carboxamide	Investigative	46228695	C22H15N3O3S	401.4	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NC(=O)C4=CC5=C(C=C4)SC=C5	IC50 = 66000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5AR3T	CID 46197875	Investigative	46197875	C19H17N7O4S	439.5	C1CC(OC1)C2=NN=C(S2)NC(=O)NC3=CC=C(C=C3)OC4=C5C(=NC=C4)NC(=O)N5	IC50 = 58000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5CGM2	Chembl4208998	Investigative	145965631	C23H22N4O3	402.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)C3=NNC(C3)C4=CC=C(C=C4)OC	IC50 ~ 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5D2IQ	5-Amino-1-phenyl-3-pyridin-4-ylpyrazole-4-carboxamide	Investigative	56950742	C15H13N5O	279.3	C1=CC=C(C=C1)N2C(=C(C(=N2)C3=CC=NC=C3)C(=O)N)N	IC50 = 64000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5K0QS	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzenesulfonamide	Investigative	46228821	C20H14F3N3O5S	465.4	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NS(=O)(=O)C4=CC=CC(=C4)OC(F)(F)F	IC50 = 94000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5LAH4	Chembl4288433	Investigative	145990512	C24H20BrN3O2S	494.4	C1COC2=C(O1)C=CC(=C2)C3CC(=NN3C(=S)NC4=CC=CC=C4)C5=CC=CC=C5Br	IC50 = 124000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5WK6X	2-(3-Phenylpropylamino)-6-(3-acetamidophenyl)pyrazine	Investigative	11602668	C21H22N4O	346.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCCCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5YQO0	7-Benzyl-8-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione	Investigative	25023945	C19H20N6O2	364.4	CC1=CC(=NN1C2=NC3=C(N2CC4=CC=CC=C4)C(=O)N(C(=O)N3C)C)C	IC50 = 57710 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B5ZCF0	Pyridoimidazolone, 5b	Investigative	42626129	C19H15N5O3	361.4	C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B62VOX	N-[2-Methyl-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228859	C22H16F3N3O4	443.4	CC1=C(C=CC=C1OC2=CC=CC3=C2NC(=O)N3)NC(=O)C4=CC(=CC=C4)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B65YIB	7-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazole-4-yl]quinoline-2(1H)-one	Investigative	71525027	C27H25N5O2	451.5	CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C=CC(=O)N5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B6M4DF	N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide	Investigative	44185900	C25H17F3N4O4	494.4	C1=CC=C2C(=C1)C(=CC=C2OC3=C4C(=NC=C3)NC(=O)N4)NC(=O)CC5=CC(=CC=C5)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B6UF4W	Ethyl 5-amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylate	Investigative	56950741	C17H13Cl3N4O2	411.7	CCOC(=O)C1=C(N(N=C1C2=CC=NC=C2)C3=C(C=C(C=C3Cl)Cl)Cl)N	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B6UMO9	1-Methyl-4-({8-[(4-methyl-1-piperazinyl)methyl]-1,2,3,5,6,7-hexahydro-s-indacen-4-yl}methyl)piperazine	Investigative	1032682	C24H38N4	382.6	CN1CCN(CC1)CC2=C3CCCC3=C(C4=C2CCC4)CN5CCN(CC5)C	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B7DVZ1	N-(9H-Pyrido[3,4-b]indol-6-ylsulfonyl)acetamide	Investigative	53379553	C13H11N3O3S	289.31	CC(=O)NS(=O)(=O)C1=CC2=C(C=C1)NC3=C2C=CN=C3	IC50 = 59110 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B82OIW	4-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide	Investigative	46228794	C20H13ClF3N3O4S	483.8	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NS(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F	IC50 = 66000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B86LJW	(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(5-methylfuran-3-yl)pyrrolidine-2,3-dione	Investigative	44569182	C24H23N3O6	449.5	CC1=CC(=CO1)C2/C(=C(/C3=CC4=C(C=C3)OCCO4)\\O)/C(=O)C(=O)N2CCCN5C=CN=C5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B8BHP3	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide	Investigative	46228525	C20H14F3N3O4S	449.4	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NS(=O)(=O)C4=CC=C(C=C4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B8GM0N	(NE)-N-[6-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]oxy-2,3-dihydroinden-1-ylidene]hydroxylamine	Investigative	25093294	C22H22N4O5	422.4	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC\\4=C(CC/C4=N\\O)C=C3	IC50 = 86000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B8HNG0	Pyridoimidazolone, 5f	Investigative	42626194	C20H14F3N5O3	429.4	C1=CC=C(C(=C1)C(F)(F)F)NC(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B8WDX9	N-[4-Methyl-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228858	C22H16F3N3O4	443.4	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)OC(F)(F)F)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B90WEO	Pyridoimidazolone, 29a	Investigative	11720025	C19H12ClF3N4O4S	484.8	C1=CC(=CC=C1NS(=O)(=O)C2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B91VYH	2-Phenoxyethylamino-6-(3-acetamidophenyl)pyrazine	Investigative	11573823	C20H20N4O2	348.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCCOC3=CC=CC=C3	IC50 = 65000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B92BRL	Pyridoimidazolone, 27f	Investigative	42625243	C23H20FN5O4	449.4	C1COCCN1C2=CC(=CC(=C2)C(=O)NC3=CC=C(C=C3)OC4=C5C(=NC=C4)NC(=O)N5)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B9CG5I	1-(3-Fluorophenyl)-3-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]urea	Investigative	46228947	C20H15FN4O3	378.4	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NC(=O)NC4=CC(=CC=C4)F	IC50 = 50200 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B9FY1M	2-Amino-4-[4-[(3,5-dimethyl-4-nitropyrazol-1-yl)methyl]-3-methoxyphenyl]-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile	Investigative	44569219	C23H23N5O5	449.5	CC1=C(C(=NN1CC2=C(C=C(C=C2)C3C(=C(OC4=C3C(=O)CCC4)N)C#N)OC)C)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B9KJT1	N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-4-(trifluoromethoxy)benzenesulfonamide	Investigative	46228853	C20H14F3N3O5S	465.4	C1=CC2=C(C(=C1)OC3=CC=C(C=C3)NS(=O)(=O)C4=CC=C(C=C4)OC(F)(F)F)NC(=O)N2	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B9T8FW	Pyridoimidazolone, 5c	Investigative	42626130	C19H14ClN5O3	395.8	C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)Cl)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	B9VLE0	2-(2-Methoxyphenylamino)-6-(3-acetamidophenyl)pyrazine	Investigative	11660026	C19H18N4O2	334.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NC3=CC=CC=C3OC	IC50 = 74000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BA14BC	N-Methyl-4-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)phenyl)ureido)phenoxy)picolinamide	Investigative	49863710	C26H30N6O3	474.6	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)CN4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BA53SV	5-Amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxamide	Investigative	56950740	C15H10Cl3N5O	382.6	C1=CN=CC=C1C2=NN(C(=C2C(=O)N)N)C3=C(C=C(C=C3Cl)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BAI7P0	1-(3,4-Difluorophenyl)-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]naphthalen-1-yl]urea	Investigative	44185069	C23H15F2N5O3	447.4	C1=CC=C2C(=C1)C(=CC=C2OC3=C4C(=NC=C3)NC(=O)N4)NC(=O)NC5=CC(=C(C=C5)F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BARY47	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-phenylethanesulfonamide	Investigative	46228553	C21H19N3O4S	409.5	C1=CC=C(C=C1)CCS(=O)(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 = 94000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BBQ0Y5	N-(2,4-Dimethoxyphenyl)-5-(3-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide	Investigative	3143674	C23H23F3N4O4	476.4	COC1=CC(=C(C=C1)NC(=O)C2=C3NC(CC(N3N=C2)C(F)(F)F)C4=CC(=CC=C4)OC)OC	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BC46GY	Chembl4285067	Investigative	145992396	C24H20ClN3O2S	450	C1COC2=C(O1)C=CC(=C2)C3CC(=NN3C(=S)NC4=CC=CC=C4)C5=CC(=CC=C5)Cl	IC50 = 95900 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BC9IB3	3-(4-Benzylpiperazin-1-yl)-1-(3-methoxyphenyl)pyrrolidine-2,5-dione	Investigative	4647084	C22H25N3O3	379.5	COC1=CC=CC(=C1)N2C(=O)CC(C2=O)N3CCN(CC3)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BCNE87	1-[2-Methyl-4-(2-morpholin-4-ylethyl)-4H-pyrazolo[1,5-a]benzimidazol-3-yl]ethanone	Investigative	751729	C18H22N4O2	326.4	CC1=NN2C3=CC=CC=C3N(C2=C1C(=O)C)CCN4CCOCC4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BDL39X	2-(3-Chloro-4-fluorobenzylamino)-6-(3-acetamidophenyl)-pyrazine	Investigative	11501578	C19H16ClFN4O	370.8	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCC3=CC(=C(C=C3)F)Cl	IC50 = 99000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BDX5F1	2,5-Dimethyl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyrazole-3-carboxamide	Investigative	46228729	C19H17N5O3	363.4	CC1=NN(C(=C1)C(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4)C	IC50 = 79000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BF28OQ	4-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzenesulfonamide	Investigative	46228554	C19H14ClN3O4S	415.9	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NS(=O)(=O)C4=CC=C(C=C4)Cl	IC50 = 68000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BF6D0T	1-[3-(5-Methylfuran-2-yl)-5-phenyl-3,4-dihydropyrazol-2-yl]-2-morpholin-4-ylethanone	Investigative	11841127	C20H23N3O3	353.4	CC1=CC=C(O1)C2CC(=NN2C(=O)CN3CCOCC3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BFA8V6	2-[4-(4-Fluorophenyl)piperazin-1-yl]-N-[(E)-(4-hydroxy-3-methoxyphenyl)methylideneamino]acetamide	Investigative	135688666	C20H23FN4O3	386.4	COC1=C(C=CC(=C1)/C=N/NC(=O)CN2CCN(CC2)C3=CC=C(C=C3)F)O	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BFW9Y3	3-Bromo-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide	Investigative	46228901	C20H14BrN3O3	424.2	C1=CC(=CC(=C1)Br)C(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 = 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BG0SI1	Chembl4291854	Investigative	145986924	C25H23N3O2S2	461.6	CSC1=CC=C(C=C1)C2=NN(C(C2)C3=CC4=C(C=C3)OCCO4)C(=S)NC5=CC=CC=C5	IC50 = 156000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BG5E8T	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-pyrrolidin-1-ylbenzamide	Investigative	46228664	C24H22N4O3	414.5	C1CCN(C1)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BGJ19Q	1-Benzyl-5-chloro-2-[(4-ethylpiperazin-1-yl)methyl]benzimidazole	Investigative	1236338	C21H25ClN4	368.9	CCN1CCN(CC1)CC2=NC3=C(N2CC4=CC=CC=C4)C=CC(=C3)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJ2E9V	N-[4-[(2-Oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	42625242	C20H13F3N4O4	430.3	C1=CC(=CC(=C1)OC(F)(F)F)C(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJ2VE8	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-phenylmethanesulfonamide	Investigative	46228552	C20H17N3O4S	395.4	C1=CC=C(C=C1)CS(=O)(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 = 87000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJ32VY	3-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-N-(1-phenylethyl)benzamide	Investigative	90655989	C29H23ClF3N3O2	538	CC(C1=CC=CC=C1)NC(=O)C2=CC=CC(=C2)C3=CC=C(C=C3)NC(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJ56EF	2-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazine	Investigative	24879329	C23H21N3O4	403.4	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJS52V	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide	Investigative	46228667	C22H17N3O5	403.4	C1COC2=C(C=CC=C2O1)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BJW59L	1,3-Bis[(4-methoxyphenyl)methyl]-2-(6-methylpyridin-2-yl)-1,3-diazinane	Investigative	1040090	C26H31N3O2	417.5	CC1=NC(=CC=C1)C2N(CCCN2CC3=CC=C(C=C3)OC)CC4=CC=C(C=C4)OC	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BK0RD6	Pyridoimidazolone, 28c	Investigative	42625246	C20H14F2N4O3	396.3	C1=CC(=CC=C1NC(=O)CC2=CC(=CC(=C2)F)F)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BK72HX	2-(4-Methoxyphenyloxyethylamino)-6-(3-acetamidophenyl)-pyrazine	Investigative	11632277	C21H22N4O3	378.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCCOC3=CC=C(C=C3)OC	IC50 = 58000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BKH9J0	N-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine	Investigative	24180721	C13H11N3	209.25	C1=CC=C(C=C1)NC2=CNC3=C2C=CC=N3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BM41PU	N-(3-(6-(2,2,3,3-Tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-ylamino)pyrazin-2-yl)phenyl)acetamide	Investigative	11633452	C20H14F4N4O3	434.3	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NC3=C4C(=CC=C3)OC(C(O4)(F)F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BMD14H	N-[4-Methoxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228907	C22H16F3N3O5	459.4	COC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)OC(F)(F)F)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BMI50W	4-Nitrobenzaldehyde (7-benzyl-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-YL)hydrazone	Investigative	5753919	C20H17N7O4	419.4	CN1C2=C(C(=O)NC1=O)N(C(=N2)N/N=C\\C3=CC=C(C=C3)[N+](=O)[O-])CC4=CC=CC=C4	IC50 = 57890 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BMIL04	5-Amino-4-(3,4-dichlorophenyl)thiopheno[2,3-d]pyrimidine-6-carboxamide	Investigative	57401314	C13H8Cl2N4OS	339.2	C1=CC(=C(C=C1C2=C3C(=C(SC3=NC=N2)C(=O)N)N)Cl)Cl	IC50 ~ 60000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BN2TR0	3-Imidazol-1-yl-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide	Investigative	46228643	C23H17N5O3	411.4	C1=CC(=CC(=C1)N2C=CN=C2)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BNAW26	6-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazole-4-yl]quinoline-2(1H)-one	Investigative	71525066	C27H25N5O2	451.5	CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)NC(=O)C=C5	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BNBA05	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-2-(trifluoromethoxy)benzamide	Investigative	46228588	C21H14F3N3O4	429.3	C1=CC=C(C(=C1)C(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4)OC(F)(F)F	IC50 = 79000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BNR17Z	3-(N-Methyl-1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one	Investigative	24894883	C22H22N2O4	378.4	CN1C=C(C2=CC=CC=C21)C3=C(CNC3=O)C4=CC(=C(C(=C4)OC)OC)OC	IC50 = 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BO9H5A	3-Fluoro-5-morpholin-4-yl-N-[4-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide	Investigative	46228946	C24H21FN4O4	448.4	C1COCCN1C2=CC(=CC(=C2)C(=O)NC3=CC=C(C=C3)OC4=CC=CC5=C4NC(=O)N5)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BOES65	N-(1-Morpholin-4-yl-2-oxo-2-phenylethyl)thiophene-2-carboxamide	Investigative	3235666	C17H18N2O3S	330.4	C1COCCN1C(C(=O)C2=CC=CC=C2)NC(=O)C3=CC=CS3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BOMY02	(NE)-N-[6-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]oxy-3,4-dihydro-2H-naphthalen-1-ylidene]hydroxylamine	Investigative	24878670	C23H24N4O5	436.5	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC4=C(C=C3)/C(=N/O)/CCC4	IC50 = 92000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BOP0A6	4-Chloro-N-[4-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethyl)benzenesulfonamide	Investigative	46228818	C20H13ClF3N3O4S	483.8	C1=CC2=C(C(=C1)OC3=CC=C(C=C3)NS(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F)NC(=O)N2	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BOQ64C	2-(2-Pyridylmethylamino)-6-(3-acetamidophenyl)pyrazine	Investigative	11573300	C18H17N5O	319.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BP3O5L	7-Benzyl-3-methyl-8-[(2Z)-2-[(3-nitrophenyl)methylidene]hydrazinyl]purine-2,6-dione	Investigative	5753911	C20H17N7O4	419.4	CN1C2=C(C(=O)NC1=O)N(C(=N2)N/N=C\\C3=CC(=CC=C3)[N+](=O)[O-])CC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BQ73UK	4-[3-[[3-(Trifluoromethoxy)phenyl]methyl]phenoxy]-1,3-dihydrobenzimidazol-2-one	Investigative	46228825	C21H15F3N2O3	400.3	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)CC4=CC(=CC=C4)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BR78UO	N-[2-Methyl-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228857	C22H16F3N3O4	443.4	CC1=C(C=C(C=C1)OC2=CC=CC3=C2NC(=O)N3)NC(=O)C4=CC(=CC=C4)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BR89IW	N-(4-Chlorophenyl)-2-phenylimidazo[1,2-a]pyrazin-3-amine	Investigative	53321817	C18H13ClN4	320.8	C1=CC=C(C=C1)C2=C(N3C=CN=CC3=N2)NC4=CC=C(C=C4)Cl	IC50 = 76000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BRX09M	2-[4-(Trifluoromethoxy)phenylamino]-6-(3-acetamidophenyl)-pyrazine	Investigative	11639649	C19H15F3N4O2	388.3	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NC3=CC=C(C=C3)OC(F)(F)F	IC50 = 84000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BS4AC5	7-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,4,4a,5-tetrahydroindeno[1,2-c]pyridazin-3-one	Investigative	52948582	C29H28N6O2	492.6	CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C6=NNC(=O)CC6C5	IC50 = 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BT14EV	3-(Dimethylamino)-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzenesulfonamide	Investigative	46228555	C21H20N4O4S	424.5	CN(C)C1=CC(=CC=C1)S(=O)(=O)NC2=CC(=CC=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BT41KL	6-(3-Fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine	Investigative	24879528	C19H18FN3O4	371.4	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC(=CC=C3)F	IC50 = 56000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BTG1O6	2-(3,4,5-Trimethoxybenzylamino)-6-(3-acetamidophenyl)pyrazine	Investigative	11704203	C22H24N4O4	408.4	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NCC3=CC(=C(C(=C3)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BTL7M6	N-[4-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]benzamide	Investigative	46228904	C20H15N3O3	345.4	C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BU01PQ	6-({6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}oxy)-1,2,3,4-tetrahydronaphthalen-1-one	Investigative	24879260	C23H23N3O5	421.4	COC1=CC(=CC(=C1OC)OC)NC2=CN=CC(=N2)OC3=CC4=C(C=C3)C(=O)CCC4	IC50 = 76000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BU42NB	N-[3-[(2-Oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamide	Investigative	46228766	C24H16F3N5O3	479.4	C1=CC=C(C=C1)N2C(=C(C=N2)C(=O)NC3=CC(=CC=C3)OC4=CC=CC5=C4NC(=O)N5)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BUJ5T8	4-[4-[(E)-3-(4-Fluorophenyl)-3-oxoprop-1-enyl]phenoxy]-N-methylpyridine-2-carboxamide	Investigative	134145603	C22H17FN2O3	376.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)/C=C/C(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BUO05K	1-(4-Amino-1,2,5-oxadiazol-3-yl)-5-[(diethylamino)methyl]-N'-(2-furylmethylene)-1H-1,2,3-triazole-4-carbohydrazide	Investigative	6877485	C15H19N9O3	373.37	CCN(CC)CC1=C(N=NN1C2=NON=C2N)C(=O)N/N=C/C3=CC=CO3	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BW61GM	1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[2-methoxy-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea	Investigative	44185126	C21H15ClF3N5O4	493.8	COC1=C(C=CC(=C1)OC2=C3C(=NC=C2)NC(=O)N3)NC(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BWLF39	Pyridoimidazolone, 29e	Investigative	42625328	C18H13FN4O4S	400.4	C1=CC(=CC=C1NS(=O)(=O)C2=CC=C(C=C2)F)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BWP36Z	Chembl4202658	Investigative	145977243	C22H19N5O4	417.4	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)C3CC(=NN3)C4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BWQZ65	Pyridoimidazolone, 27a	Investigative	42625163	C19H14N4O3	346.3	C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BX5Z3F	CID 44186294	Investigative	44186294	C21H15ClF3N5O3	477.8	CC1=C(C=CC(=C1)NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=C4C(=NC=C3)NC(=O)N4	IC50 = 59000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BX6N0E	N-[2,4-Dichloro-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228905	C21H12Cl2F3N3O4	498.2	C1=CC(=CC(=C1)OC(F)(F)F)C(=O)NC2=CC(=C(C=C2Cl)Cl)OC3=CC=CC4=C3NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BX7O9D	3-[(2,5-Dimethoxyphenyl)(hydroxy)methyl]-4-(morpholin-4-ylmethyl)-1-benzofuran-5-ol	Investigative	660701	C22H25NO6	399.4	COC1=CC(=C(C=C1)OC)C(C2=COC3=C2C(=C(C=C3)O)CN4CCOCC4)O	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BXT60J	2-(3-Chloro-4-fluorophenylamino)-6-(3-acetamidophenyl)-pyrazine	Investigative	11681939	C18H14ClFN4O	356.8	CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)NC3=CC(=C(C=C3)F)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BY08RA	2-Chloro-N-[3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]pyridine-4-carboxamide	Investigative	46228697	C19H13ClN4O3	380.8	C1=CC(=CC(=C1)OC2=CC=CC3=C2NC(=O)N3)NC(=O)C4=CC(=NC=C4)Cl	IC50 = 93000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BY76RZ	1-[2-(4-Chlorophenyl)-5-methylpyrazol-3-yl]-3-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]urea	Investigative	46197772	C23H18ClN7O3	475.9	CC1=NN(C(=C1)NC(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4)C5=CC=C(C=C5)Cl	IC50 = 70000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BY7TB4	5-Amino-3-pyridin-4-yl-1-(2,4,6-trichlorophenyl)pyrazole-4-carboxylic acid	Investigative	56950743	C15H9Cl3N4O2	383.6	C1=CN=CC=C1C2=NN(C(=C2C(=O)O)N)C3=C(C=C(C=C3Cl)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BYRQ56	Pyridoimidazolone, 29d	Investigative	42625327	C19H13F3N4O4S	450.4	C1=CC(=CC=C1C(F)(F)F)S(=O)(=O)NC2=CC=C(C=C2)OC3=C4C(=NC=C3)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BZ1R6B	N-[2-Chloro-5-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]phenyl]-3-(trifluoromethoxy)benzamide	Investigative	46228860	C21H13ClF3N3O4	463.8	C1=CC(=CC(=C1)OC(F)(F)F)C(=O)NC2=C(C=CC(=C2)OC3=CC=CC4=C3NC(=O)N4)Cl	IC50 ~ 100000 nM	Poor binder
T99089	Serine/threonine-protein kinase B-raf	BZ1X8H	CID 44186297	Investigative	44186297	C26H17ClF3N5O3	539.9	C1=CC=C(C=C1)C2=C(C=CC(=C2)OC3=C4C(=NC=C3)NC(=O)N4)NC(=O)NC5=CC(=C(C=C5)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder