TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99840	Gamma-secretase	B0EP5W	Chembl4204874	Investigative	145977593	C21H31Cl3N4O	461.9	CC1=C(N2C=CC=C(C2=N1)OCC3=CC=CC=C3)CN(C)CCN(C)C.Cl.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B0FT4B	2-(9-Octylcarbazol-2-yl)oxyethanamine	Investigative	56683027	C22H30N2O	338.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCCN	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B0NUD1	(R)-2-(4-Methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid	Investigative	10341444	C21H22F3NO4	409.4	CC[C@H](CC1=CC(=C(C=C1)OC)C(=O)NCC2=CC=C(C=C2)C(F)(F)F)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B1HE9Z	CID 59472544	Investigative	59472544	C26H21F7N6O2	582.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN(N=N3)[C@H]4CCC5=C(C=CC=C5F)N(C4=O)CC(F)(F)F)OCC(F)(F)F	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B26CBV	2-[4-[(E)-C-(4-Chlorophenyl)-N-hexadecoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid	Investigative	46878849	C33H48ClNO4	558.2	CCCCCCCCCCCCCCCCO/N=C(\\C1=CC=C(C=C1)OC(C)(C)C(=O)O)/C2=CC=C(C=C2)Cl	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B2C9LF	2,2,2-Trifluoro-N-[2-(9-octylcarbazol-2-yl)oxyethyl]-N-(2,2,2-trifluoroacetyl)acetamide	Investigative	56679704	C26H28F6N2O3	530.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCCN(C(=O)C(F)(F)F)C(=O)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B2VFZ4	2-[9-[[3-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]methyl]carbazol-2-yl]oxyacetic acid	Investigative	46878739	C23H16F3N3O3	439.4	C1=CC=C2C(=C1)C3=C(N2CC4=CC(=CC=C4)C5(N=N5)C(F)(F)F)C=C(C=C3)OCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B3AKE8	4-[6-(5-Tert-butyl-2-methylanilino)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]pyrimidin-4-yl]oxy-2-methylbutan-2-ol	Investigative	46229972	C33H47N5O3	561.8	CC1=C(C=C(C=C1)C(C)(C)C)NC2=CC(=NC(=N2)N3CCN(C(C3)(C)C)C4=CC=C(C=C4)OC)OCCC(C)(C)O	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B3DF2Z	(3Z)-3-[[4-[[4-(Dimethylamino)phenyl]diazenyl]phenyl]methylidene]-1H-indol-2-one	Investigative	71459623	C23H20N4O	368.4	CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)/C=C\\3/C4=CC=CC=C4NC3=O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B3IE0F	Sulindac sulfide	Investigative	5352624	C20H17FO2S	340.4	CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O	IC50 = 53000 nM	Poor binder
T99840	Gamma-secretase	B48MZD	N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7-methylpurin-6-amine	Investigative	46884705	C28H35N7O	485.6	CC1=C(C=C(C=C1)C(C)(C)C)NC2=NC(=NC3=C2N(C=N3)C)N4CCN(CC4)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B4D5JA	N-[(3,4-Dichlorophenyl)methyl]-N-propan-2-ylnaphthalene-2-carboxamide	Investigative	127053276	C21H19Cl2NO	372.3	CC(C)N(CC1=CC(=C(C=C1)Cl)Cl)C(=O)C2=CC3=CC=CC=C3C=C2	IC50 = 135000 nM	Poor binder
T99840	Gamma-secretase	B4DV5S	2-(9-Octylcarbazol-2-yl)oxyacetonitrile	Investigative	56676365	C22H26N2O	334.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCC#N	IC50 = 74000 nM	Poor binder
T99840	Gamma-secretase	B4IJA2	4-[4-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-2-methoxyphenoxy]butanenitrile	Investigative	71452401	C20H17ClN2O3	368.8	COC1=C(C=CC(=C1)/C=C\\2/C3=C(C=CC(=C3)Cl)NC2=O)OCCCC#N	IC50 ~ 160000 nM	Poor binder
T99840	Gamma-secretase	B4R6XZ	2-[9-[[4-(2-Cyanophenyl)phenyl]methyl]carbazol-2-yl]oxyacetic acid	Investigative	46878738	C28H20N2O3	432.5	C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CN3C4=CC=CC=C4C5=C3C=C(C=C5)OCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B5BGK7	(2S,3R)-2,3-Bis(benzyloxy)cyclohexanone	Investigative	44413568	C20H22O3	310.4	C1C[C@H]([C@@H](C(=O)C1)OCC2=CC=CC=C2)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B5HL6Z	2-[3,4-Bis[4-(trifluoromethyl)phenyl]phenyl]acetic acid	Investigative	46231466	C22H14F6O2	424.3	C1=CC(=CC=C1C2=C(C=C(C=C2)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B5U0KN	N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]pyrimidin-4-amine	Investigative	46229973	C35H50N6O2	586.8	CC1=C(C=C(C=C1)C(C)(C)C)NC2=CC(=NC(=N2)N3CCN(C(C3)(C)C)C4=CC=C(C=C4)OC)OCCC5CCCN5C	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B6BQF4	Methyl 2-benzyl-3-oxopiperidine-1-carboxylate	Investigative	44413659	C14H17NO3	247.29	COC(=O)N1CCCC(=O)C1CC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B6FLJ4	2-(9-Octadecylcarbazol-2-yl)oxyacetic acid	Investigative	46878651	C32H47NO3	493.7	CCCCCCCCCCCCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B6NQ8E	2-(9-Octylcarbazol-2-yl)oxyacetamide	Investigative	56673118	C22H28N2O2	352.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCC(=O)N	IC50 = 104000 nM	Poor binder
T99840	Gamma-secretase	B7FAL5	(2R)-2-[3-Phenylmethoxy-5-[4-(trifluoromethyl)phenyl]phenyl]pentanoic acid	Investigative	11697625	C25H23F3O3	428.4	CCC[C@H](C1=CC(=CC(=C1)C2=CC=C(C=C2)C(F)(F)F)OCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B7LT8K	(2S,3R)-3-(Benzyloxy)-5-hydroxy-2-methoxycyclohexanone	Investigative	44413797	C14H18O4	250.29	CO[C@H]1[C@@H](CC(CC1=O)O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B84IKM	2-[2-[4-Chloro-2-(trifluoromethyl)phenoxy]ethyl]-7-(4-methyl-1H-imidazole-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione	Investigative	68380260	C21H18ClF3N4O3	466.8	CC1=CN(C=N1)C2=CC=C3C(=O)N(CCN3C2=O)CCOC4=C(C=C(C=C4)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B8F0UH	3-[2-(Carboxymethoxy)-9-octylcarbazol-3-yl]propanoic acid	Investigative	56666200	C25H31NO5	425.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C(=C3)CCC(=O)O)OCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B8FH6S	N-[(3R)-5-Chloro-2,3-dihydro-1-benzofuran-3-yl]-3-methoxy-4-(4-methylimidazol-1-yl)benzamide	Investigative	57404337	C20H18ClN3O3	383.8	CC1=CN(C=N1)C2=C(C=C(C=C2)C(=O)N[C@H]3COC4=C3C=C(C=C4)Cl)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B8N2JH	(2S,3R)-3-(Benzyloxy)-2-methoxycyclohexanone	Investigative	44413810	C14H18O3	234.29	CO[C@H]1[C@@H](CCCC1=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	B8P7ON	3-(9-Octylcarbazol-2-yl)oxypropanoic acid	Investigative	56673051	C23H29NO3	367.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	B8TB6E	2-[3-(Hydroxymethyl)-9-octylcarbazol-2-yl]oxyethanol	Investigative	56669597	C23H31NO3	369.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C(=C3)CO)OCCO	IC50 = 80000 nM	Poor binder
T99840	Gamma-secretase	B8U7RW	N-[(3,4-Dichlorophenyl)methyl]-1-hydroxy-N-propan-2-ylnaphthalene-2-carboxamide	Investigative	127053277	C21H19Cl2NO2	388.3	CC(C)N(CC1=CC(=C(C=C1)Cl)Cl)C(=O)C2=C(C3=CC=CC=C3C=C2)O	IC50 = 85000 nM	Poor binder
T99840	Gamma-secretase	B9C1IL	1-[(4-Tert-butylphenyl)methyl]-4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazole	Investigative	53307787	C24H27N5O	401.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN(N=N3)CC4=CC=C(C=C4)C(C)(C)C)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B9CVJ0	2-[4-[[4-[3-Methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]methyl]phenyl]-1,3-benzoxazole	Investigative	53307788	C27H22N6O2	462.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN(N=N3)CC4=CC=C(C=C4)C5=NC6=CC=CC=C6O5)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	B9KN8S	Sodium;2-[(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]pentyl]piperidin-4-yl]acetate	Investigative	46231522	C25H27F6N2NaO2	524.5	CCCC[C@H](C1=CN=C(C=C1)C(F)(F)F)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)[O-].[Na+]	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BA76TX	N-[2-(9-Octylcarbazol-2-yl)oxyethyl]formamide	Investigative	56666135	C23H30N2O2	366.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCCNC=O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BB5IK4	2-Methylpropyl 2-(9-octylcarbazol-2-yl)oxyacetate	Investigative	56669599	C26H35NO3	409.6	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCC(=O)OCC(C)C	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BBC4U3	2-[[Benzyl(propan-2-yl)amino]methyl]-2-ethyl-1-naphthalen-2-ylbutan-1-ol	Investigative	127047958	C27H35NO	389.6	CCC(CC)(CN(CC1=CC=CC=C1)C(C)C)C(C2=CC3=CC=CC=C3C=C2)O	IC50 ~ 75000 nM	Poor binder
T99840	Gamma-secretase	BCU87G	2-(9-Octylcarbazol-2-yl)oxybenzoic acid	Investigative	56683026	C27H29NO3	415.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OC4=CC=CC=C4C(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BD0V7B	Benzenepropanoic acid, alpha-ethyl-4-methoxy-3-((((4-(trifluoromethyl)phenyl)methyl)amino)carbonyl)-, (alphaS)-	Investigative	10341445	C21H22F3NO4	409.4	CC[C@@H](CC1=CC(=C(C=C1)OC)C(=O)NCC2=CC=C(C=C2)C(F)(F)F)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BDB34C	N-[(3R)-5-Chloro-4-fluoro-2,3-dihydro-1-benzofuran-3-yl]-6-methoxy-5-(4-methylimidazol-1-yl)pyridine-2-carboxamide	Investigative	57404500	C19H16ClFN4O3	402.8	CC1=CN(C=N1)C2=C(N=C(C=C2)C(=O)N[C@H]3COC4=C3C(=C(C=C4)Cl)F)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BF9D2A	(3S)-6-Fluoro-3-[4-[3-fluoro-2-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one	Investigative	122187802	C25H21F5N6O2	532.5	CC1=CN(C=N1)C2=C(C(=C(C=C2)C3=CN(N=N3)[C@H]4CCC5=C(C=CC=C5F)N(C4=O)CC(F)(F)F)OC)F	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BG42TB	9-Octylcarbazol-2-ol	Investigative	15208713	C20H25NO	295.4	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BG5E9Y	Dapt	Investigative	5311272	C23H26F2N2O4	432.5	C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BG60PW	Methyl 2-benzyl-3-hydroxypiperidine-1-carboxylate	Investigative	44413822	C14H19NO3	249.3	COC(=O)N1CCCC(C1CC2=CC=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BG83WM	CID 46884679	Investigative	46884679	C31H38F3N7O	581.7	CC1=C(C=C(C=C1)C(C)(C)C)NC2=NC(=NC3=C2N(C(=N3)C(F)(F)F)C)N4CCN(C(C4)(C)C)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BGB96J	N-[(1S)-1-(4-Fluorophenyl)ethyl]-5-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,3-thiazol-2-amine	Investigative	56659627	C22H21FN4OS	408.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN=C(S3)N[C@@H](C)C4=CC=C(C=C4)F)OC	IC50 = 50118.72 nM	Poor binder
T99840	Gamma-secretase	BHVZ15	3-[[4-(Trifluoromethyl)benzyl]carbamoyl]-4-methoxy-alpha-ethylbenzeneacrylic acid	Investigative	9909323	C21H20F3NO4	407.4	CC/C(=C\\C1=CC(=C(C=C1)OC)C(=O)NCC2=CC=C(C=C2)C(F)(F)F)/C(=O)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BI34YU	Benzyl 2-benzyl-3-oxopiperidine-1-carboxylate	Investigative	23509685	C20H21NO3	323.4	C1CC(=O)C(N(C1)C(=O)OCC2=CC=CC=C2)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BIG2N0	(2S,3R)-2-Hydroxy-3-methoxycyclohexanone	Investigative	44413510	C7H12O3	144.17	CO[C@@H]1CCCC(=O)[C@H]1O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BIRD13	N-(5-Tert-butyl-2-methylphenyl)-6-methoxy-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]pyrimidin-4-amine	Investigative	46229902	C29H39N5O2	489.7	CC1=C(C=C(C=C1)C(C)(C)C)NC2=CC(=NC(=N2)N3CCN(C(C3)(C)C)C4=CC=C(C=C4)OC)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BJ62TN	CID 59472470	Investigative	59472470	C24H21F4N7O2	515.5	CC1=NN(C=N1)C2=C(C=C(C=C2)C3=CN(N=N3)[C@H]4CCC5=C(C=CC=C5F)N(C4=O)CC(F)(F)F)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BJQ98M	6-Chloro-2-ethyl-9-octylcarbazole	Investigative	56679701	C22H28ClN	341.9	CCCCCCCCN1C2=C(C=C(C=C2)Cl)C3=C1C=C(C=C3)CC	EC50 = 50000 nM	Poor binder
T99840	Gamma-secretase	BJW8T9	5-[6-[[(1S)-1-(4-Fluorophenyl)ethyl]amino]pyridin-3-yl]-N-methyl-2-(4-methylimidazol-1-yl)benzamide	Investigative	56659628	C25H24FN5O	429.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN=C(C=C3)N[C@@H](C)C4=CC=C(C=C4)F)C(=O)NC	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BK24UA	N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]-7-methylpurin-6-amine	Investigative	44626366	C30H39N7O	513.7	CC1=C(C=C(C=C1)C(C)(C)C)NC2=NC(=NC3=C2N(C=N3)C)N4CCN(C(C4)(C)C)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BK39AF	5-[3-(Dimethylamino)-4-(4-methylimidazol-1-yl)phenyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]pyridin-2-amine	Investigative	56663089	C25H26FN5	415.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN=C(C=C3)N[C@@H](C)C4=CC=C(C=C4)F)N(C)C	IC50 = 50118.72 nM	Poor binder
T99840	Gamma-secretase	BKE1Z9	Benzyl 2-benzyl-3-hydroxypiperidine-1-carboxylate	Investigative	44413821	C20H23NO3	325.4	C1CC(C(N(C1)C(=O)OCC2=CC=CC=C2)CC3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BKVA40	3-Hydroxy-4-(9-octylcarbazol-2-yl)oxy-2H-furan-5-one	Investigative	56676366	C24H27NO4	393.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OC4=C(COC4=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BL7Q5V	CID 25025157	Investigative	25025157	C34H48N6O3	588.8	CC1=C(C=C(C=C1)C(C)(C)C)NC2=CC(=NC(=N2)N3CCN(C(C3)(C)C)C4=CC=C(C=C4)OC)OCCN5CCOCC5	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BM1NS9	2-(9-Octylcarbazol-2-yl)oxyethanesulfonic acid	Investigative	56673052	C22H29NO4S	403.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCCS(=O)(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BN8AE6	Sodium;2-[(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]heptyl]piperidin-4-yl]acetate	Investigative	46231577	C27H31F6N2NaO2	552.5	CCCCCC[C@H](C1=CN=C(C=C1)C(F)(F)F)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)[O-].[Na+]	IC50 = 100000 nM	Poor binder
T99840	Gamma-secretase	BNB69L	3-Hydroxy-4-(9-octylcarbazol-2-yl)oxy-1,2-dihydropyrrol-5-one	Investigative	56669537	C24H28N2O3	392.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OC4=C(CNC4=O)O	IC50 = 72000 nM	Poor binder
T99840	Gamma-secretase	BNLH26	Benzyl 2-(6-chloro-9-octylcarbazol-2-yl)propanoate	Investigative	16098417	C30H34ClNO2	476	CCCCCCCCN1C2=C(C=C(C=C2)Cl)C3=C1C=C(C=C3)C(C)C(=O)OCC4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BNM20T	3-(Benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-ol	Investigative	59570713	C23H27NO	333.5	CC(C)N(CCC(C1=CC2=CC=CC=C2C=C1)O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BP2QK7	(2S,3R)-2-(Benzyloxy)-5-hydroxy-3-methoxycyclohexanone	Investigative	15071516	C14H18O4	250.29	CO[C@@H]1CC(CC(=O)[C@H]1OCC2=CC=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BPG7F8	8-[(E)-4-(4-Methyl-1H-imidazole-1-yl)-3-methoxybenzylidene]-4alpha-(3,4,5-trifluorophenyl)-3,4,5,6,7,8-hexahydro-1,4a-diaza-2-oxanaphthalene	Investigative	46201983	C25H23F3N4O2	468.5	CC1=CN(C=N1)C2=C(C=C(C=C2)/C=C/3\\CCCN4C3=NOC[C@@H]4C5=CC(=C(C(=C5)F)F)F)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BQER57	Methyl 2-(3-formyl-9-octylcarbazol-2-yl)oxyacetate	Investigative	56662734	C24H29NO4	395.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C(=C3)C=O)OCC(=O)OC	IC50 = 89000 nM	Poor binder
T99840	Gamma-secretase	BQZ65X	9-Octyl-2-(2H-tetrazol-5-ylmethoxy)carbazole	Investigative	56673053	C22H27N5O	377.5	CCCCCCCCN1C2=CC=CC=C2C3=C1C=C(C=C3)OCC4=NNN=N4	IC50 = 102000 nM	Poor binder
T99840	Gamma-secretase	BRQD56	Sodium;2-[(2S,4R)-1-[(1R)-4-methyl-1-[6-(trifluoromethyl)pyridin-3-yl]pentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate	Investigative	46216678	C26H29F6N2NaO2	538.5	CC(C)CC[C@H](C1=CN=C(C=C1)C(F)(F)F)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)[O-].[Na+]	IC50 = 100000 nM	Poor binder
T99840	Gamma-secretase	BU58GZ	2-{2-[4-Fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione	Investigative	68380152	C21H18F4N4O3	450.4	CC1=CN(C=N1)C2=CC=C3C(=O)N(CCN3C2=O)CCOC4=C(C=C(C=C4)F)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BU8X3D	N-Benzyl-1-hydroxy-N-propan-2-ylnaphthalene-2-carboxamide	Investigative	24768566	C21H21NO2	319.4	CC(C)N(CC1=CC=CC=C1)C(=O)C2=C(C3=CC=CC=C3C=C2)O	IC50 = 96000 nM	Poor binder
T99840	Gamma-secretase	BUIE07	2-[9-[4-[[4-(Dimethylamino)phenyl]diazenyl]phenyl]sulfonylcarbazol-2-yl]oxyacetic acid	Investigative	46878737	C28H24N4O5S	528.6	CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)N3C4=CC=CC=C4C5=C3C=C(C=C5)OCC(=O)O	IC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BV4EZ5	Chembl4209756	Investigative	145963822	C26H29ClN2O	421	CCCCC1=CC=C(C=C1)C2=C(N=C3N2C=CC=C3OCC4=CC=CC=C4C)C.Cl	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BVD1U5	2-[4-[(E)-C-(4-Chlorophenyl)-N-tetradecoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid	Investigative	46878848	C31H44ClNO4	530.1	CCCCCCCCCCCCCCO/N=C(\\C1=CC=C(C=C1)OC(C)(C)C(=O)O)/C2=CC=C(C=C2)Cl	EC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BWVO84	Sodium;2-[(2S,4R)-1-[(1R)-2-methyl-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate	Investigative	46231469	C24H25F6N2NaO2	510.4	CC(C)[C@H](C1=CN=C(C=C1)C(F)(F)F)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)[O-].[Na+]	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BX0W3T	[(3S,8E)-3-(4-Fluorophenyl)-8-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-6,7-dihydro-5H-[1,2,4]oxadiazolo[4,3-a]pyridin-3-yl]methanol	Investigative	56946423	C25H25FN4O3	448.5	CC1=CN(C=N1)C2=C(C=C(C=C2)/C=C/3\\CCCN4C3=NO[C@]4(CO)C5=CC=C(C=C5)F)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BXMZ90	(2S,3R)-3-Hydroxy-2-methoxycyclohexanone	Investigative	44413812	C7H12O3	144.17	CO[C@H]1[C@@H](CCCC1=O)O	IC50 ~ 100000 nM	Poor binder
T99840	Gamma-secretase	BYRD34	1-Hydroxy-N-[(4-methoxyphenyl)methyl]-N-propan-2-ylnaphthalene-2-carboxamide	Investigative	127030015	C22H23NO3	349.4	CC(C)N(CC1=CC=C(C=C1)OC)C(=O)C2=C(C3=CC=CC=C3C=C2)O	IC50 = 95000 nM	Poor binder
T99840	Gamma-secretase	BYX53A	2-[4-[(E)-C-(4-Chlorophenyl)-N-decoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid	Investigative	46878786	C27H36ClNO4	474	CCCCCCCCCCO/N=C(\\C1=CC=C(C=C1)OC(C)(C)C(=O)O)/C2=CC=C(C=C2)Cl	EC50 ~ 80000 nM	Poor binder
T99840	Gamma-secretase	BZ15AT	Sodium;2-[(2S,4R)-1-[(R)-cyclopropyl-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate	Investigative	46231471	C24H23F6N2NaO2	508.4	C1CN([C@@H](C[C@@H]1CC(=O)[O-])C2=CC=C(C=C2)C(F)(F)F)[C@H](C3CC3)C4=CN=C(C=C4)C(F)(F)F.[Na+]	IC50 = 50118.72 nM	Poor binder
T99840	Gamma-secretase	BZB4U6	CID 46229901	Investigative	46229901	C34H46N6O3	586.8	CC1=C(C=C(C=C1)C(C)(C)C)NC2=NC(=NC(=C2)C(=O)NCC3CCCO3)N4CCN(C(C4)(C)C)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T99840	Gamma-secretase	BZD2T4	2-(6-Chloro-9-octylcarbazol-2-yl)propanoic acid	Investigative	16098434	C23H28ClNO2	385.9	CCCCCCCCN1C2=C(C=C(C=C2)Cl)C3=C1C=C(C=C3)C(C)C(=O)O	IC50 = 100000 nM	Poor binder