Wcorina 04070615403D 1 1.00000 0.00000 0 CORINA evaluation license 3.40 0067 02.08.2006 44 46 0 0 0 999 V2000 0.0118 1.3850 0.0467 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0892 0.0534 -0.1278 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2307 1.9191 0.2434 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2353 2.1534 0.0198 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2335 0.8342 0.1964 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5081 -0.3515 -0.0395 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3819 2.9335 1.3278 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2071 3.1164 -1.1390 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5335 1.9675 2.4745 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8430 4.3395 -1.0350 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8496 -0.6915 -0.3247 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4676 3.0958 0.4282 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.8181 5.2261 -2.0995 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1519 4.8823 -3.2719 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5405 2.7771 -2.3017 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5250 0.7728 2.2661 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.5165 3.6548 -3.3696 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.6784 2.4313 3.7316 N 0 0 0 0 0 0 0 0 0 0 0 0 -2.4435 6.4294 -1.9990 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6114 0.7838 0.3296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1771 -1.5606 -0.1369 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1293 5.7468 -4.3214 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.1076 6.7145 -0.7661 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4316 5.3245 -5.4949 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2676 -0.4336 0.2298 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5566 -1.5957 -0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.0790 1.4727 -0.0939 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.4959 3.5484 1.4854 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.2629 3.5730 1.2726 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3596 4.6037 -0.1241 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0411 1.8225 -2.3775 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0029 3.3835 -4.2801 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6852 3.3868 3.8983 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7759 1.8095 4.4697 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1723 1.6889 0.5100 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6265 -2.4720 -0.3171 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5636 7.7031 -0.8191 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8806 5.9668 -0.5885 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3850 6.6909 0.0496 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6132 5.1359 -5.2482 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.8852 4.4104 -5.8781 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.4907 6.1050 -6.2534 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3419 -0.4738 0.3331 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0790 -2.5379 -0.0772 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 3 1 0 0 0 0 1 4 1 0 0 0 0 2 6 1 0 0 0 0 2 11 2 0 0 0 0 3 5 1 0 0 0 0 3 12 2 0 0 0 0 4 7 1 0 0 0 0 4 8 1 0 0 0 0 4 27 1 0 0 0 0 5 20 2 0 0 0 0 5 6 1 0 0 0 0 6 21 2 0 0 0 0 7 9 1 0 0 0 0 7 28 1 0 0 0 0 7 29 1 0 0 0 0 8 10 2 0 0 0 0 8 15 1 0 0 0 0 9 16 2 0 0 0 0 9 18 1 0 0 0 0 10 13 1 0 0 0 0 10 30 1 0 0 0 0 13 19 1 0 0 0 0 13 14 2 0 0 0 0 14 17 1 0 0 0 0 14 22 1 0 0 0 0 15 17 2 0 0 0 0 15 31 1 0 0 0 0 17 32 1 0 0 0 0 18 33 1 0 0 0 0 18 34 1 0 0 0 0 19 23 1 0 0 0 0 20 25 1 0 0 0 0 20 35 1 0 0 0 0 21 26 1 0 0 0 0 21 36 1 0 0 0 0 22 24 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 26 2 0 0 0 0 25 43 1 0 0 0 0 26 44 1 0 0 0 0 M END > 245068 > Phosphodiesterase 4C > Homo sapiens > 9873600 > Bioorg. Med. Chem. Lett.|1998|8|19|2669 > 3a > 1998 > 245068 > TNF-alpha > Homo sapiens > 8765505 > J. Med. Chem.|1996|39|17|3238 > 10 > 1996 $$$$ Wcorina 04070615393D 1 1.00000 0.00000 CORINA evaluation license 3.40 0067 02.08.2006 41 43 0 0 0 0 0 0 0 0999 V2000 -0.0134 1.4145 0.2332 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.6385 -3.8871 1.3515 N 0 0 0 0 0 0 0 0 0 0 0 0 -2.5495 -3.4974 2.6349 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1729 -0.5777 0.8915 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0118 0.0959 0.6571 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1435 -2.0122 1.3526 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1508 2.0784 0.0022 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.8367 -2.1662 2.7262 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2330 2.0566 0.0386 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.0293 -2.9008 0.4514 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.9787 -4.1220 3.5818 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.3839 0.0580 0.6928 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4161 1.3742 0.2698 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3592 1.3216 0.0976 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2630 3.3511 -0.3770 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.5501 3.9455 -0.5556 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4648 1.9860 -0.7414 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8607 1.3085 1.5564 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4025 1.3841 1.4287 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5996 2.3535 0.2368 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0489 -4.7156 1.0582 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9567 -0.4060 0.8041 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1209 -2.3877 1.3875 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5530 -1.3600 2.8845 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.0973 -2.1835 3.5269 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.4195 -3.4021 -0.3002 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.8020 -2.2999 -0.0282 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.3070 -0.4729 0.8727 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.3638 1.8687 0.1153 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1893 0.3022 -0.2488 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0924 3.9288 0.3898 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.4312 4.9767 -0.8881 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.1087 3.3844 -1.3047 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8321 1.2887 -1.4944 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0796 2.8857 -1.2213 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4800 2.1741 2.0985 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5639 0.3850 2.0536 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8457 1.7930 2.3366 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8198 0.4030 1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5718 2.1925 -0.2290 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4997 3.3878 0.5658 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 2 0 0 0 0 1 7 1 0 0 0 0 1 9 1 0 0 0 0 2 10 1 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 8 1 0 0 0 0 3 11 2 0 0 0 0 4 5 1 0 0 0 0 4 6 1 0 0 0 0 4 12 2 0 0 0 0 5 22 1 0 0 0 0 6 8 1 0 0 0 0 6 10 1 0 0 0 0 6 23 1 0 0 0 0 7 14 1 0 0 0 0 8 24 1 0 0 0 0 8 25 1 0 0 0 0 9 13 2 0 0 0 0 9 15 1 0 0 0 0 10 26 1 0 0 0 0 10 27 1 0 0 0 0 12 13 1 0 0 0 0 12 28 1 0 0 0 0 13 29 1 0 0 0 0 14 17 1 0 0 0 0 14 18 1 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 16 31 1 0 0 0 0 16 32 1 0 0 0 0 16 33 1 0 0 0 0 17 20 1 0 0 0 0 17 34 1 0 0 0 0 17 35 1 0 0 0 0 18 19 1 0 0 0 0 18 36 1 0 0 0 0 18 37 1 0 0 0 0 19 20 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 M END > 104872 > Phosphodiesterase 4D > Homo sapiens > 16263279 > Bioorg. Med. Chem. Lett.|2006|16|3|718 > "1, Rolipram" > 2006 > 104872 > TNF-alpha > Homo sapiens > 8568809 > J. Med. Chem.|1996|39|1|2 > Rolipram > 1996 $$$$ Wcorina 04070615403D 1 1.00000 0.00000 0 CORINA evaluation license 3.40 0067 02.08.2006 46 48 0 0 0 999 V2000 0.0111 1.3839 0.0457 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0871 0.0522 -0.1289 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2307 1.9168 0.2414 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2353 2.1534 0.0198 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2324 0.8309 0.1936 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5056 -0.3541 -0.0417 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3801 2.9336 1.3279 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2071 3.1164 -1.1390 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8430 4.3394 -1.0349 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5317 1.9677 2.4748 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8526 -0.6919 -0.3247 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4688 3.0932 0.4264 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.8181 5.2261 -2.0995 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1520 4.8823 -3.2719 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5405 2.7771 -2.3017 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5245 0.7775 2.2671 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.5166 3.6548 -3.3696 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4436 6.4294 -1.9989 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.6746 2.4297 3.7269 O 0 0 0 0 0 0 0 0 0 0 0 0 3.6104 0.7791 0.3257 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1735 -1.5637 -0.1404 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1294 5.7468 -4.3214 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.1076 6.7145 -0.7661 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8154 1.4421 4.7819 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4317 5.3245 -5.4949 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5531 -1.6001 -0.0069 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2653 -0.4389 0.2254 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.0797 1.4735 -0.0932 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.4934 3.5477 1.4849 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.2606 3.5739 1.2735 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3596 4.6037 -0.1240 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0411 1.8225 -2.3775 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0029 3.3835 -4.2801 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1722 1.6837 0.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6219 -2.4747 -0.3202 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8806 5.9668 -0.5884 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3850 6.6909 0.0497 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5636 7.7031 -0.8191 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.9227 1.9481 5.7414 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.6982 0.8315 4.5925 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.9311 0.8052 4.8038 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6131 5.1359 -5.2482 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.8853 4.4104 -5.8780 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.4908 6.1050 -6.2534 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0746 -2.5427 -0.0837 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3396 -0.4801 0.3282 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 3 1 0 0 0 0 1 4 1 0 0 0 0 2 6 1 0 0 0 0 2 11 2 0 0 0 0 3 5 1 0 0 0 0 3 12 2 0 0 0 0 4 7 1 0 0 0 0 4 8 1 0 0 0 0 4 28 1 0 0 0 0 5 20 2 0 0 0 0 5 6 1 0 0 0 0 6 21 2 0 0 0 0 7 10 1 0 0 0 0 7 29 1 0 0 0 0 7 30 1 0 0 0 0 8 9 2 0 0 0 0 8 15 1 0 0 0 0 9 13 1 0 0 0 0 9 31 1 0 0 0 0 10 16 2 0 0 0 0 10 19 1 0 0 0 0 13 18 1 0 0 0 0 13 14 2 0 0 0 0 14 17 1 0 0 0 0 14 22 1 0 0 0 0 15 17 2 0 0 0 0 15 32 1 0 0 0 0 17 33 1 0 0 0 0 18 23 1 0 0 0 0 19 24 1 0 0 0 0 20 27 1 0 0 0 0 20 34 1 0 0 0 0 21 26 1 0 0 0 0 21 35 1 0 0 0 0 22 25 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 25 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 26 27 2 0 0 0 0 26 45 1 0 0 0 0 27 46 1 0 0 0 0 M END > 245501 > Phosphodiesterase 4A > Homo sapiens > 9873600 > Bioorg. Med. Chem. Lett.|1998|8|19|2669 > 2a > 1998 > 245501 > TNF-alpha > Homo sapiens > 8765505 > J. Med. Chem.|1996|39|17|3238 > 21 > 1996 $$$$