Structure145 Wcorina 06010716253D 1 1.00000 0.00000 CORINA evaluation license 3.40 0067 02.08.2006 77 80 0 0 0 0 0 0 0 0999 V2000 -0.0160 1.3271 0.0093 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0021 -0.0041 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1218 -0.7019 -0.0120 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3072 -0.0793 -0.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3245 1.3404 -0.0130 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4525 -0.7633 -0.0347 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6197 -0.1520 -0.0430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7140 1.2556 -0.0367 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7819 -0.9095 -0.0578 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7091 -2.2552 -0.0635 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8382 -2.9911 -0.0779 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6251 -2.8054 -0.0558 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.2015 -0.6829 0.0099 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0415 1.9160 -0.0462 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6796 2.2214 1.1549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9151 2.8361 1.1399 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5203 3.1492 -0.0640 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8915 2.8489 -1.2590 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6587 2.2286 -1.2563 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0992 2.0289 0.0025 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5553 2.0161 -0.0210 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9783 1.8956 -2.5591 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0214 1.8814 2.4672 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1719 -5.0410 -0.1005 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7591 -4.4540 -0.0842 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.5919 0.2927 1.3697 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.3903 -0.3773 0.0709 N 0 0 3 0 0 0 0 0 0 0 0 0 -8.5449 -1.2831 -0.1336 C 0 0 0 0 0 0 0 0 0 0 0 0 -9.6435 -0.6816 0.7779 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.1256 -1.1245 0.0547 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.9528 -0.1420 0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.8557 -0.2119 1.9494 N 0 0 3 0 0 0 0 0 0 0 0 0 -3.6356 -0.9203 0.0320 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4627 0.0622 0.0260 C 0 0 0 0 0 0 0 0 0 0 0 0 -9.5669 0.8529 2.6692 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5569 3.1940 -2.5664 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6061 3.1674 2.4375 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6469 -0.4705 -0.0640 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7032 -2.5521 -0.0841 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.2113 -1.6529 0.0048 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4872 3.6302 -0.0709 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0724 3.1086 0.0089 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5978 3.0953 -0.0163 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3562 2.7353 -2.8691 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7312 1.6998 -3.3226 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3553 1.0109 -2.4278 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3201 0.8792 2.7746 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3298 2.6011 3.2256 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9383 1.9181 2.3507 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7131 -4.7102 0.7859 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1130 -6.1294 -0.1052 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6960 -4.7017 -0.9940 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2349 -4.7933 0.8093 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2179 -4.7848 -0.9706 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.7617 0.0614 2.0370 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.6581 1.3707 1.2224 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.8623 -1.2708 -1.1763 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.2977 -2.2969 0.1814 H 0 0 0 0 0 0 0 0 0 0 0 0 -10.1424 0.1531 0.2856 H 0 0 0 0 0 0 0 0 0 0 0 0 -10.3628 -1.4450 1.0745 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.0657 -1.7565 0.9408 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.0827 -1.7469 -0.8390 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.0127 0.4900 -0.8373 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.9956 0.4804 0.9426 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5756 -1.5522 0.9180 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5927 -1.5427 -0.8618 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5056 0.6847 0.9198 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5227 0.6942 -0.8601 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.7982 1.6654 1.9804 H 0 0 0 0 0 0 0 0 0 0 0 0 -10.4923 0.4548 3.0854 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.9378 1.2288 3.4761 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1753 2.3573 -2.8914 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7953 3.3969 -3.3193 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1814 4.0775 -2.4341 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2303 2.3272 2.7416 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2283 4.0521 2.3023 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8594 3.3625 3.2073 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 38 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 25 1 0 0 0 0 11 39 1 0 0 0 0 13 34 1 0 0 0 0 13 40 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 37 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 2 0 0 0 0 18 36 1 0 0 0 0 19 22 1 0 0 0 0 20 42 1 0 0 0 0 21 43 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 23 49 1 0 0 0 0 24 25 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 27 1 0 0 0 0 26 32 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 28 1 0 0 0 0 27 30 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 32 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 30 31 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 31 33 1 0 0 0 0 31 63 1 0 0 0 0 31 64 1 0 0 0 0 32 35 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 33 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 35 69 1 0 0 0 0 35 70 1 0 0 0 0 35 71 1 0 0 0 0 36 72 1 0 0 0 0 36 73 1 0 0 0 0 36 74 1 0 0 0 0 37 75 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 M END > (1,110) 9240345-6e > (1,110) FGFR > (1,110) 140 > (1,110) 0 > (1,110) N > (1,110) FGFR $$$$ Structure142 Wcorina 06010716253D 1 1.00000 0.00000 CORINA evaluation license 3.40 0067 02.08.2006 68 71 0 0 0 0 0 0 0 0999 V2000 -0.0160 1.3271 0.0093 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0021 -0.0041 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1218 -0.7019 -0.0120 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3072 -0.0793 -0.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3245 1.3404 -0.0130 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4525 -0.7633 -0.0347 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6197 -0.1520 -0.0430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7140 1.2557 -0.0362 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7820 -0.9096 -0.0583 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7091 -2.2554 -0.0645 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8382 -2.9913 -0.0793 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6251 -2.8055 -0.0567 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.2016 -0.6830 0.0099 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0414 1.9159 -0.0451 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6798 2.2213 1.1569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9167 2.8361 1.1419 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5220 3.1492 -0.0617 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8941 2.8491 -1.2571 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6597 2.2292 -1.2556 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0992 2.0289 0.0025 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5553 2.0162 -0.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8766 1.8468 -2.7569 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.9212 1.8300 2.6686 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7590 -4.4541 -0.0860 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9991 -4.9180 -1.3303 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1718 -5.0412 -0.1028 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0235 -4.9309 1.1680 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.1923 -1.7812 -1.2414 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.0789 -1.0854 0.0545 N 0 0 3 0 0 0 0 0 0 0 0 0 -7.3618 -0.3795 0.2813 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.3641 -1.1533 -0.6110 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.9528 -0.1421 0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.6357 -0.9203 0.0320 C 0 0 0 0 0 0 0 0 0 0 0 0 -7.5317 -1.4901 -1.7973 N 0 0 3 0 0 0 0 0 0 0 0 0 -2.4628 0.0622 0.0260 C 0 0 0 0 0 0 0 0 0 0 0 0 -8.0728 -2.6577 -2.5057 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6470 -0.4707 -0.0644 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7032 -2.5523 -0.0855 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.2114 -1.6529 0.0048 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4120 3.0730 2.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4888 3.6305 -0.0682 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3718 3.0965 -2.1936 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0724 3.1085 0.0085 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5979 3.0953 -0.0149 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5231 -4.5784 -2.2237 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9402 -6.0064 -1.3353 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9926 -4.4997 -1.3183 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7132 -4.7108 0.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1129 -6.1296 -0.1079 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6958 -4.7016 -0.9963 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0170 -4.5126 1.1800 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9646 -6.0193 1.1630 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5649 -4.6004 2.0545 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.4231 -1.4187 -1.9233 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.0793 -2.8554 -1.0946 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.6540 -0.4418 1.3295 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.2889 0.6606 -0.0366 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.7113 -2.0575 -0.1109 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.2034 -0.5178 -0.8934 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.0128 0.4899 -0.8373 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.9957 0.4804 0.9426 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5757 -1.5523 0.9180 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5928 -1.5427 -0.8618 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5057 0.6846 0.9198 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5228 0.6942 -0.8601 H 0 0 0 0 0 0 0 0 0 0 0 0 -8.1562 -3.4959 -1.8140 H 0 0 0 0 0 0 0 0 0 0 0 0 -9.0582 -2.4163 -2.9044 H 0 0 0 0 0 0 0 0 0 0 0 0 -7.4057 -2.9272 -3.3245 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 37 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 24 1 0 0 0 0 11 38 1 0 0 0 0 13 35 1 0 0 0 0 13 39 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 2 0 0 0 0 18 42 1 0 0 0 0 19 22 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 34 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 32 1 0 0 0 0 30 31 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 34 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 33 35 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 36 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 M END > (245) 9240345-6b > (245) FGFR > (245) 51 > (245) -1 > (245) P > (245) FGFR $$$$ Structure140 Wcorina 06010716253D 1 1.00000 0.00000 CORINA evaluation license 3.40 0067 02.08.2006 39 41 0 0 0 0 0 0 0 0999 V2000 -0.0160 1.3271 0.0093 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0021 -0.0041 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1218 -0.7019 -0.0120 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3072 -0.0793 -0.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3245 1.3404 -0.0130 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4525 -0.7633 -0.0347 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6197 -0.1520 -0.0430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7140 1.2557 -0.0362 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7820 -0.9096 -0.0583 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7091 -2.2554 -0.0645 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8382 -2.9913 -0.0793 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6251 -2.8055 -0.0567 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.2016 -0.6830 0.0099 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0414 1.9159 -0.0451 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6798 2.2213 1.1569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9167 2.8361 1.1419 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5220 3.1492 -0.0617 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8941 2.8491 -1.2571 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6597 2.2292 -1.2556 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0992 2.0289 0.0025 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5553 2.0162 -0.0200 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8766 1.8468 -2.7569 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.9212 1.8300 2.6686 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.1718 -5.0412 -0.1028 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7590 -4.4541 -0.0860 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6470 -0.4707 -0.0644 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7032 -2.5523 -0.0855 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.0367 -0.1896 0.0206 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.2114 -1.6529 0.0048 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4120 3.0730 2.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4888 3.6305 -0.0682 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3718 3.0965 -2.1936 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0724 3.1085 0.0085 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5979 3.0953 -0.0149 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6958 -4.7016 -0.9963 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7132 -4.7108 0.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1129 -6.1296 -0.1079 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2350 -4.7938 0.8074 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2176 -4.7846 -0.9725 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 20 2 0 0 0 0 2 3 2 0 0 0 0 2 13 1 0 0 0 0 3 4 1 0 0 0 0 4 6 2 0 0 0 0 4 5 1 0 0 0 0 5 20 1 0 0 0 0 5 21 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 7 9 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 9 10 1 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 10 12 2 0 0 0 0 11 25 1 0 0 0 0 11 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 14 15 2 0 0 0 0 14 19 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 18 1 0 0 0 0 17 31 1 0 0 0 0 18 19 2 0 0 0 0 18 32 1 0 0 0 0 19 22 1 0 0 0 0 20 33 1 0 0 0 0 21 34 1 0 0 0 0 24 25 1 0 0 0 0 24 35 1 0 0 0 0 24 36 1 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 M END > (413) 9240345-4f > (413) FGFR > (413) 130 > (413) -1 > (413) P > (413) FGFR $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7i csChFnd70/04170815452D 61 64 0 0 0 0 0 0 0 0999 V2000 1.2234 16.3023 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7164 13.6992 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 14.5244 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7785 17.2384 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3654 16.3251 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 19.0730 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3278 19.9363 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9501 18.9497 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3337 19.7111 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 14.5970 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9182 17.2030 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5500 16.2311 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3644 21.8568 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4310 24.5484 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3971 22.7583 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3739 22.7717 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4080 24.5618 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4334 25.4479 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3941 21.6321 3.5241 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3437 21.6622 -3.5114 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6515 11.9019 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2611 10.8936 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8286 8.9578 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5094 7.9049 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0769 5.9690 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3532 4.2228 -1.6671 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0604 2.1190 0.2694 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3424 3.1093 0.1984 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6353 5.2131 -1.7383 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6907 4.9580 -0.1033 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0048 2.3743 -1.3654 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6186 1.3632 -1.3863 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9827 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5010 13.7794 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 19.7821 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9419 15.9964 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5515 16.9782 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3705 14.9956 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4558 25.2479 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4154 25.2716 -2.7439 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4600 26.8478 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 11.3127 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0030 11.2147 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0247 11.2015 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 8.6368 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 8.6499 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2514 8.2259 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2730 8.2128 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3350 5.6479 1.0766 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3133 5.6611 -1.2310 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0387 4.3796 -2.8928 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1470 4.7309 -0.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8395 2.6033 1.3444 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8035 0.7421 0.4556 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5486 2.6012 -0.8546 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6568 2.9527 1.4240 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8921 6.5901 -1.9243 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8561 4.7290 -2.8132 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4820 1.8332 -0.3710 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3234 0.0000 -1.1599 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2479 1.5065 -2.6435 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 33 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 34 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 35 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 12 38 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 39 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 40 1 0 0 0 0 18 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 30 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 29 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 28 30 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 29 30 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 31 32 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 M END > (12) 10 > (12) C24H29Cl2N5O > (12) 474.432 > (12) FGFR-P10 > (12) 1,6-naphthyridin-2(1H)-one deriv. 7i > (12) FGFR-1 Tyrosine Kinase > (12) 170 > (12) BINDDB > (12) <2007 > (12) P > (12) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7j csChFnd70/04170815452D 64 67 0 0 0 0 0 0 0 0999 V2000 1.2250 19.2550 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7199 16.6486 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3211 17.4748 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7821 20.1924 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3711 19.2779 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7817 22.0293 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3334 22.8937 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9577 21.9059 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3431 22.6683 -0.0304 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2483 17.5475 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9258 20.1569 -0.0286 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5596 19.1839 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3700 24.8167 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4368 27.5118 1.5758 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4027 25.7194 1.5775 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3795 25.7328 -1.5554 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4136 27.5252 -1.5389 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4391 28.4123 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3998 24.5918 3.5286 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3493 24.6219 -3.5159 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6550 14.8490 -0.0260 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2666 13.8395 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8335 11.9011 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5165 10.8469 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0835 8.9086 -0.0826 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7665 7.8542 -0.1044 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0108 5.5873 1.1848 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5414 3.6605 1.0657 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4468 3.0149 0.0587 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9163 4.9418 0.1776 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3507 5.9931 -0.1110 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1069 2.6092 1.3544 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6911 0.7481 1.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 19.9364 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5081 16.7290 -0.0421 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5730 22.7394 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9521 18.9488 -1.3878 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5625 19.9319 0.6122 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3799 17.9467 0.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4615 28.2122 2.7901 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4210 28.2358 -2.7474 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4657 29.8141 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5425 14.2591 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0095 14.1611 -1.2072 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0312 14.1478 1.1031 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0904 11.5797 1.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0688 11.5928 -1.2037 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2594 11.1683 -1.2361 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2811 11.1552 1.0744 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3406 8.5870 1.0779 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3189 8.6003 -1.2325 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5095 8.1756 -1.2647 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5310 8.1625 1.0456 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8591 6.3700 0.9339 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5039 5.8740 2.4795 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5749 3.3483 2.0509 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0153 3.3811 -0.2176 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9536 2.7283 -1.2362 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5987 2.2321 0.3096 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4425 5.2212 1.4610 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8827 5.2539 -0.8075 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1312 0.3944 0.0974 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8725 0.0000 1.5641 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7610 0.4689 2.3768 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 34 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 35 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 36 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 37 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 40 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 41 1 0 0 0 0 18 42 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 46 1 0 0 0 0 23 47 1 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 26 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 31 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 32 1 0 0 0 0 28 56 1 0 0 0 0 28 57 1 0 0 0 0 29 32 1 0 0 0 0 29 30 1 0 0 0 0 29 58 1 0 0 0 0 29 59 1 0 0 0 0 30 31 1 0 0 0 0 30 60 1 0 0 0 0 30 61 1 0 0 0 0 32 33 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 M END > (13) 11 > (13) C25H31Cl2N5O > (13) 488.4588 > (13) FGFR-P11 > (13) 1,6-naphthyridin-2(1H)-one deriv. 7j > (13) FGFR-1 Tyrosine Kinase > (13) 110 > (13) BINDDB > (13) <2007 > (13) P > (13) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7k csChFnd70/04170815452D 54 57 0 0 0 0 0 0 0 0999 V2000 1.2235 14.0146 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7164 11.4116 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3157 12.2368 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7785 14.9508 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3656 14.0375 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 16.7856 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3280 17.6489 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9502 16.6623 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3338 17.4237 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2467 12.3094 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9184 14.9154 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5501 13.9436 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3645 19.5693 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4312 22.2611 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3972 20.4709 1.5755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3740 20.4842 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4081 22.2745 -1.5370 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4335 23.1605 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3942 19.3447 3.5241 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3438 19.3747 -3.5115 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6515 9.6143 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2612 8.6059 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8287 6.6701 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5096 5.6172 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7592 3.3520 1.2160 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3110 1.4213 1.1119 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1811 0.7836 0.1123 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6584 2.7079 0.2063 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0943 3.7584 -0.0822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8534 0.4215 1.3548 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.6952 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5011 11.4918 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5711 17.4947 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9420 13.7088 -1.3861 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5516 14.6906 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3707 12.7081 0.6134 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4559 22.9606 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4155 22.9842 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4601 24.5604 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5406 9.0249 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0032 8.9271 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0248 8.9138 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 6.3490 1.1054 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 6.3621 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2515 5.9382 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2732 5.9251 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6010 4.1199 0.9580 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2486 3.6540 2.5067 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3758 1.0989 2.1212 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7566 1.1331 -0.1557 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7103 0.4770 -1.1843 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3218 0.0000 0.3985 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1942 2.9996 1.4810 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6167 3.0056 -0.7888 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 37 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 29 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 30 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 29 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 M END > (14) 12 > (14) C22H24Cl2N4O2 > (14) 447.3632 > (14) FGFR-P12 > (14) 1,6-naphthyridin-2(1H)-one deriv. 7k > (14) FGFR-1 Tyrosine Kinase > (14) 570 > (14) BINDDB > (14) <2007 > (14) P > (14) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7l csChFnd70/04170815452D 57 60 0 0 0 0 0 0 0 0999 V2000 1.2234 15.5678 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7164 12.9647 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 13.7900 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7785 16.5040 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3654 15.5906 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 18.3387 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3278 19.2020 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9502 18.2154 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3337 18.9768 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 13.8625 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9182 16.4686 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5500 15.4968 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3644 21.1224 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4310 23.8141 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3971 22.0240 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3739 22.0373 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4080 23.8275 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4334 24.7134 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3941 20.8977 3.5241 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3437 20.9278 -3.5114 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6516 11.1675 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2611 10.1593 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8286 8.2234 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5094 7.1705 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0769 5.2346 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3423 2.3743 0.1984 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9336 4.8943 1.1768 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6206 3.8554 1.0578 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0453 1.3607 0.0893 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6908 4.2236 -0.1033 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2508 2.0568 1.3141 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.2483 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5010 13.0450 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 19.0478 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9419 15.2620 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5515 16.2438 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3705 14.2613 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4558 24.5135 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4154 24.5371 -2.7439 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4600 26.1134 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 10.5783 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0030 10.4804 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0247 10.4672 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 7.9023 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 7.9154 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2515 7.4915 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2731 7.4784 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3350 4.9134 1.0766 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3133 4.9267 -1.2310 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4452 1.8967 -0.7836 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7734 2.2043 1.4808 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3901 4.7646 2.4749 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1982 6.2564 0.9089 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2002 4.0409 -0.2177 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5193 4.2991 2.0542 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8046 0.0000 0.3852 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5789 1.4737 -1.2144 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 30 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 29 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 31 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 M END > (15) 13 > (15) C23H26Cl2N4O2 > (15) 461.39 > (15) FGFR-P13 > (15) 1,6-naphthyridin-2(1H)-one deriv. 7l > (15) FGFR-1 Tyrosine Kinase > (15) 230 > (15) BINDDB > (15) <2007 > (15) P > (15) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7m csChFnd70/04170815452D 48 51 0 0 0 0 0 0 0 0999 V2000 1.2234 14.0010 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7162 11.3980 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3153 12.2232 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7783 14.9371 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3652 14.0237 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7780 16.7716 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3276 17.6349 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9499 16.6483 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3334 17.4097 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 12.2958 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9180 14.9017 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5497 13.9299 -0.0487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3642 19.5552 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4308 22.2469 1.5737 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3969 20.4568 1.5754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3737 20.4701 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4078 22.2602 -1.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4332 23.1462 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3939 19.3306 3.5239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3435 19.3607 -3.5112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6514 9.6008 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2609 8.5925 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8284 6.6568 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5092 5.6040 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8812 2.7286 1.3234 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4984 1.1225 -0.9349 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8522 2.7309 -1.5141 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5246 1.1588 0.8034 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0951 3.7503 -0.0822 N 0 0 3 0 0 0 0 0 0 0 0 0 0.0000 14.6814 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5008 11.4783 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5710 17.4808 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9415 13.6951 -1.3860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5511 14.6769 0.6114 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3702 12.6945 0.6133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4556 22.9463 2.7863 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4152 22.9699 -2.7437 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4598 24.5461 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 9.0116 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0028 8.9137 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0245 8.9005 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0863 6.3358 1.1053 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0648 6.3489 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2512 5.9250 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2728 5.9119 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9825 3.1434 2.6568 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2386 0.0000 -1.7306 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9293 3.1382 -2.8514 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 33 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 29 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 29 1 0 0 0 0 25 28 2 0 0 0 0 25 46 1 0 0 0 0 26 28 1 0 0 0 0 26 27 2 0 0 0 0 26 47 1 0 0 0 0 27 29 1 0 0 0 0 27 48 1 0 0 0 0 M END > (16) 14 > (16) C21H19Cl2N5O > (16) 428.32 > (16) FGFR-P14 > (16) 1,6-naphthyridin-2(1H)-one deriv. 7m > (16) FGFR-1 Tyrosine Kinase > (16) 210 > (16) BINDDB > (16) <2007 > (16) P > (16) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7n csChFnd70/04170815452D 42 45 0 0 0 0 0 0 0 0999 V2000 4.1542 7.9435 0.5514 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4434 5.6217 0.0795 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8489 6.3745 -0.1941 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5215 8.7953 0.2939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9046 7.9893 -0.0888 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5335 10.4400 0.4111 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8955 11.2265 0.1495 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3091 10.3552 -0.2451 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5251 11.0489 -0.4792 O 0 0 0 0 0 0 0 0 0 0 0 0 4.1629 6.4151 0.4372 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2696 8.7890 -0.3501 N 0 0 3 0 0 0 0 0 0 0 0 0 9.6915 7.9306 -0.7451 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9401 12.9486 0.2642 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3211 15.2698 1.7829 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2808 13.6639 1.6842 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6484 13.8621 -1.0490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6923 15.4669 -0.9343 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0246 16.1687 0.4782 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6525 12.5379 3.3231 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.2316 12.9837 -2.8229 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3746 4.0091 -0.0232 N 0 0 3 0 0 0 0 0 0 0 0 0 3.9423 3.2452 0.1092 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4257 1.0892 1.0369 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1067 1.7329 0.3715 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2029 3.1274 -0.4305 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6163 3.8852 -0.5635 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8428 1.8409 0.9082 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0888 8.5434 0.8501 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8816 5.7161 -0.4839 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4815 11.0662 0.7027 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7720 7.8022 -2.0062 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7036 8.5691 -0.3191 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6568 6.7821 -0.2039 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5841 15.8248 2.8813 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4670 16.1754 -1.9499 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0571 17.4241 0.5617 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3204 3.4122 -0.1869 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3466 0.0000 1.6624 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.1425 0.4736 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1707 3.6267 -0.9491 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6907 4.9744 -1.1896 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8726 1.3374 1.4278 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 28 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 29 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 30 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 31 1 0 0 0 0 12 32 1 0 0 0 0 12 33 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 34 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 35 1 0 0 0 0 18 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 24 1 0 0 0 0 23 27 2 0 0 0 0 23 38 1 0 0 0 0 24 25 2 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 26 41 1 0 0 0 0 27 42 1 0 0 0 0 M END > (17) 15 > (17) C21H15Cl2N3O > (17) 396.275 > (17) FGFR-P15 > (17) 1,6-naphthyridin-2(1H)-one deriv. 7n > (17) FGFR-1 Tyrosine Kinase > (17) 2200 > (17) BINDDB > (17) <2007 > (17) P > (17) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7o csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.6908 7.9014 -0.5375 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0220 5.6390 -0.1958 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4241 6.3829 -0.1855 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0536 8.7423 -0.5407 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4564 7.9623 -0.3600 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0414 10.3506 -0.7220 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3997 11.1274 -0.7188 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8344 10.2835 -0.5288 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0473 10.9688 -0.5246 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7224 6.4070 -0.3683 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8176 8.7520 -0.3581 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2601 7.9211 -0.1685 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4195 12.8112 -0.9070 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3573 15.3303 0.1893 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3376 13.7616 0.3725 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5268 13.4536 -2.3639 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5452 15.0241 -2.5312 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4576 15.9599 -1.2588 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2110 12.9738 2.1905 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.6374 12.2813 -3.9625 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9766 4.0611 -0.0229 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5756 3.3139 0.1068 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9679 3.2398 0.9259 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9730 1.1395 -0.3170 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3782 1.8393 -0.4685 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3354 4.0184 0.8211 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8249 1.8471 0.3612 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6090 8.4827 -0.6695 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4725 5.7452 -0.0447 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9741 10.9566 -0.8613 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6955 7.5839 -1.2869 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0924 8.6571 0.3969 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0657 6.9040 0.5256 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2936 16.0672 1.1785 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6284 15.5228 -3.6582 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4724 17.1873 -1.3958 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9206 3.4790 0.0077 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7785 1.4724 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8081 0.0000 -0.7642 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3127 1.2541 -1.0251 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4448 5.1575 1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 28 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 29 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 30 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 31 1 0 0 0 0 12 32 1 0 0 0 0 12 33 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 34 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 35 1 0 0 0 0 18 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 38 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 39 1 0 0 0 0 25 40 1 0 0 0 0 26 41 1 0 0 0 0 M END > (18) 16 > (18) C20H14Cl2N4O > (18) 397.2628 > (18) FGFR-P16 > (18) 1,6-naphthyridin-2(1H)-one deriv. 7o > (18) FGFR-1 Tyrosine Kinase > (18) 3500 > (18) BINDDB > (18) <2007 > (18) P > (18) TRAIN $$$$ csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 4.0298 8.9929 0.1730 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6905 7.3889 -0.3130 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0525 7.4685 0.1876 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4166 9.7873 -0.1006 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7760 8.9211 -0.3482 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4651 11.4194 -0.1307 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2352 11.2076 -0.6548 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4691 11.8399 -0.8972 O 0 0 0 0 0 0 0 0 0 0 0 0 8.1552 9.6538 -0.6201 N 0 0 3 0 0 0 0 0 0 0 0 0 6.8465 12.1408 -0.4028 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9354 13.8498 -0.4416 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7102 14.6409 -1.8282 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7942 16.2343 -1.8562 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1009 17.0456 -0.5138 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3253 16.2684 0.8645 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2383 14.6756 0.9096 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5120 13.7027 2.6421 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3261 13.6249 -3.5142 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3547 6.6908 -0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3134 5.0957 -0.0232 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8967 4.3253 0.1078 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4038 2.1709 1.0275 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5549 8.7369 -0.8749 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1818 4.1854 -0.4283 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0938 2.8017 0.3654 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5785 4.9482 -0.5586 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8083 2.9281 0.9020 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0976 2.3087 1.5521 O 0 0 0 0 0 0 0 0 0 0 0 0 4.9200 0.8734 2.3486 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9654 9.6160 0.3623 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4281 12.0874 0.0578 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6206 16.8480 -2.9287 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1657 18.2915 -0.5421 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5645 16.9086 1.9085 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2657 4.5091 -0.0949 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3309 1.0901 1.6469 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6800 8.4946 -2.1043 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5583 9.3811 -0.4697 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4679 7.6527 -0.2401 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1555 4.6736 -0.9435 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.2094 0.4640 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6439 6.0289 -1.1788 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0335 0.5092 2.8106 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0999 1.0163 3.2935 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4912 0.0000 1.5490 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 23 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 26 1 0 0 0 0 21 27 2 0 0 0 0 22 25 2 0 0 0 0 22 27 1 0 0 0 0 22 36 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 25 1 0 0 0 0 24 26 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (178) 176 > (178) C21H16Cl2N4O2 > (178) 427.289 > (178) FGFR-P176 > (178) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 47 > (178) FGFR-1 Tyrosine Kinase > (178) 3200 > (178) BINDDB > (178) <2007 > (178) P > (178) TRAIN $$$$ csChFnd70/04170815452D 31 33 0 0 0 0 0 0 0 0999 V2000 1.0758 4.4595 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7668 2.8656 -0.0241 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0963 2.9428 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4134 2.1702 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3691 0.5841 -0.0225 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4811 5.2506 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8560 4.3900 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5330 6.8744 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3374 6.6656 -0.0192 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5877 7.2954 -0.0287 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2536 5.1199 -0.0267 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6694 4.2087 -0.0456 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9329 7.5929 -0.0008 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0260 9.2933 0.0062 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0500 10.1042 -1.3772 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1365 11.6892 -1.3625 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1996 12.4726 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1761 11.6757 1.3948 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0832 10.0909 1.3963 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0457 9.0932 3.1239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.9723 9.1231 -3.1129 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0787 0.0192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3885 0.0539 -0.0160 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3185 0.0000 -0.0347 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4842 7.5383 0.0224 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0086 3.9888 -1.2314 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5800 4.8398 0.5389 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4730 3.1197 0.5414 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1552 12.3182 -2.4324 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2678 13.7120 0.0246 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2261 12.2941 2.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 6 1 0 0 0 0 1 22 1 0 0 0 0 2 4 2 0 0 0 0 2 7 1 0 0 0 0 3 4 1 0 0 0 0 4 5 1 0 0 0 0 5 23 1 0 0 0 0 5 24 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 7 11 1 0 0 0 0 8 13 2 0 0 0 0 8 25 1 0 0 0 0 9 11 1 0 0 0 0 9 13 1 0 0 0 0 9 10 2 0 0 0 0 11 12 1 0 0 0 0 12 26 1 0 0 0 0 12 27 1 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 14 19 1 0 0 0 0 14 15 2 0 0 0 0 15 16 1 0 0 0 0 15 21 1 0 0 0 0 16 17 2 0 0 0 0 16 29 1 0 0 0 0 17 18 1 0 0 0 0 17 30 1 0 0 0 0 18 19 2 0 0 0 0 18 31 1 0 0 0 0 19 20 1 0 0 0 0 M END > (180) 178 > (180) C14H10Cl2N4O > (180) 321.1652 > (180) FGFR-P178 > (180) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 2 > (180) FGFR-1 Tyrosine Kinase > (180) 1300 > (180) BINDDB > (180) <2007 > (180) P > (180) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7p csChFnd70/04170815452D 46 49 0 0 0 0 0 0 0 0999 V2000 6.7819 7.9328 0.5491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0692 5.6148 0.0788 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4722 6.3662 -0.1945 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1472 8.7832 0.2920 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5278 7.9783 -0.0897 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1590 10.4249 0.4086 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5189 11.2101 0.1474 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9300 10.3401 -0.2462 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1440 11.0327 -0.4800 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7907 6.4070 0.4357 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8907 8.7765 -0.3506 N 0 0 3 0 0 0 0 0 0 0 0 0 12.3101 7.9197 -0.7451 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5633 12.9293 0.2614 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9428 15.2469 1.7771 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9032 13.6436 1.6788 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2720 13.8409 -1.0498 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3153 15.4429 -0.9357 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6470 16.1439 0.4744 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2749 12.5199 3.3150 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.8569 12.9634 -2.8206 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.0005 4.0052 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5684 3.2415 0.1098 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0576 1.0872 1.0377 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8339 3.1266 -0.4317 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2460 3.8811 -0.5625 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4706 1.8403 0.9080 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7360 1.7300 0.3710 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3451 0.9876 0.4987 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0326 1.7156 -0.2158 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7185 8.5318 0.8470 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5033 5.7090 -0.4832 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1088 11.0501 0.6994 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3903 7.7917 -2.0040 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3203 8.5569 -0.3198 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2754 6.7731 -0.2050 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2057 15.8013 2.8734 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0902 16.1500 -1.9494 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6793 17.3971 0.5575 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9449 3.4094 -0.1854 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9803 0.0000 1.6624 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8045 3.6262 -0.9504 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3219 4.9686 -1.1872 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4994 1.3395 1.4267 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.0041 -0.0272 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8548 2.8622 0.2955 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2415 1.8355 -1.4607 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 33 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 40 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 41 1 0 0 0 0 25 42 1 0 0 0 0 26 43 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 29 46 1 0 0 0 0 M END > (19) 17 > (19) C22H17Cl2N3O2 > (19) 426.3012 > (19) FGFR-P17 > (19) 1,6-naphthyridin-2(1H)-one deriv. 7p > (19) FGFR-1 Tyrosine Kinase > (19) 2200 > (19) BINDDB > (19) <2007 > (19) P > (19) TRAIN $$$$ csChFnd70/04170815452D 34 36 0 0 0 0 0 0 0 0999 V2000 1.0758 5.9136 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7667 4.3198 -0.0236 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0963 4.3970 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4811 6.7046 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8559 5.8441 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5330 8.3285 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3374 8.1196 -0.0192 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5876 8.7495 -0.0283 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2536 6.5739 -0.0262 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6692 5.6629 -0.0440 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9328 9.0469 -0.0008 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0259 10.7472 0.0074 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0495 11.5592 -1.3755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1359 13.1441 -1.3597 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1995 13.9265 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1770 13.1285 1.3976 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0837 11.5439 1.3980 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0473 10.5449 3.1248 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.9711 10.5793 -3.1116 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.4134 3.6245 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3691 2.0383 -0.0230 N 0 0 3 0 0 0 0 0 0 0 0 0 0.8880 1.2376 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.5327 0.0192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4842 8.9923 0.0224 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0091 5.4424 -1.2295 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5796 6.2942 0.5407 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4725 4.5739 0.5433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1542 13.7739 -2.4292 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2674 15.1659 0.0287 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2275 13.7462 2.4731 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3185 1.4542 -0.0353 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2494 1.5526 1.0169 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2303 1.5642 -1.0286 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0823 0.0000 -0.0226 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 23 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 24 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 25 1 0 0 0 0 10 26 1 0 0 0 0 10 27 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 28 1 0 0 0 0 15 16 1 0 0 0 0 15 29 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 31 1 0 0 0 0 22 32 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 M END > (182) 180 > (182) C15H12Cl2N4O > (182) 335.192 > (182) FGFR-P180 > (182) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 > (182) FGFR-1 Tyrosine Kinase > (182) 2500 > (182) BINDDB > (182) <2007 > (182) P > (182) TRAIN $$$$ csChFnd70/04170815452D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2022 7.8331 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2096 6.0519 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2252 6.1382 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7728 8.7172 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3093 7.7554 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8308 10.5320 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9649 10.2986 -0.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3623 11.0024 -0.0316 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8713 8.5712 -0.0293 N 0 0 3 0 0 0 0 0 0 0 0 0 7.4535 7.5529 -0.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3952 11.3348 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4993 13.2350 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5256 14.1425 -1.5372 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6222 15.9137 -1.5196 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6932 16.7881 0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6682 15.8964 1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5639 14.1254 1.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5231 13.0090 3.4923 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4380 13.0474 -3.4775 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6972 5.2748 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6476 3.5021 -0.0257 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9924 2.6073 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2973 0.6659 -0.0293 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.5251 0.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6587 11.2738 0.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8333 7.3065 -1.3741 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4709 8.2584 0.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2336 6.3359 0.6072 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6426 16.6176 -2.7148 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7691 18.1733 0.0321 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7245 16.5866 2.7639 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7087 2.8494 -0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2787 2.9593 1.1365 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2574 2.9723 -1.1496 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0109 0.3138 -1.1812 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0324 0.3008 1.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0658 0.0000 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 24 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 25 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 26 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 22 23 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 M END > (183) 181 > (183) C16H14Cl2N4O > (183) 349.2188 > (183) FGFR-P181 > (183) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 > (183) FGFR-1 Tyrosine Kinase > (183) 960 > (183) BINDDB > (183) <2007 > (183) P > (183) TRAIN $$$$ csChFnd70/04170815452D 40 42 0 0 0 0 0 0 0 0999 V2000 2.1117 7.7441 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1191 5.9628 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 2.1347 6.0491 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6823 8.6283 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2189 7.6664 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7403 10.4430 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8745 10.2097 -0.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2719 10.9135 -0.0316 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7809 8.4821 -0.0293 N 0 0 3 0 0 0 0 0 0 0 0 0 8.3631 7.4638 -0.0492 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3047 11.2459 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4088 13.1462 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4352 14.0537 -1.5372 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5318 15.8250 -1.5196 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6028 16.6995 0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5777 15.8077 1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4734 14.0366 1.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4327 12.9202 3.4924 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3476 12.9586 -3.4776 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6067 5.1857 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5571 3.4130 -0.0257 N 0 0 3 0 0 0 0 0 0 0 0 0 1.9017 2.5181 -0.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2315 2.3591 -1.8560 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1315 0.7248 0.7554 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9094 8.4361 0.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5682 11.1849 0.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7430 7.2175 -1.3741 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3806 8.1694 0.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1432 6.2468 0.6072 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5522 16.5289 -2.7149 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6787 18.0846 0.0321 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6341 16.4979 2.7640 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6182 2.7602 -0.0394 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9841 3.2429 0.7545 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6932 -1.8483 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0679 3.6366 -2.4051 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1492 1.6342 -2.6259 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6091 0.8381 2.0666 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8999 0.0590 0.7631 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0491 0.0000 -0.0145 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 25 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 26 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 15 31 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (184) 182 > (184) C17H16Cl2N4O > (184) 363.2456 > (184) FGFR-P182 > (184) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 23 > (184) FGFR-1 Tyrosine Kinase > (184) 700 > (184) BINDDB > (184) <2007 > (184) P > (184) TRAIN $$$$ csChFnd70/04170815452D 43 45 0 0 0 0 0 0 0 0999 V2000 2.5839 10.8078 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6190 9.0101 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6071 9.0973 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1689 11.7000 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7196 10.7294 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2274 13.5315 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3904 13.2960 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8007 14.0064 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2960 11.5527 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8927 10.5250 -0.0496 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8063 14.3419 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9113 16.2596 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9378 17.1754 -1.5514 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0353 18.9629 -1.5336 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1070 19.8454 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0817 18.9454 1.5763 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9765 17.1581 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9354 16.0314 3.5244 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.8494 16.0702 -3.5095 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.0926 8.2259 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0426 6.4369 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3721 5.5338 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6798 3.5745 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9353 2.6313 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2429 0.6720 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3706 11.5061 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0446 14.2803 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2760 10.2763 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9195 11.2370 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6708 9.2967 0.6127 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0559 19.6733 -2.7398 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1836 21.2433 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1386 19.6420 2.7893 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1134 5.7781 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6518 5.8891 1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6303 5.9022 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4000 3.2192 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4216 3.2061 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2149 2.9866 1.1438 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1934 2.9997 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9632 0.3167 -1.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9847 0.3036 1.1119 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 -0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 26 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 27 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 10 30 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 31 1 0 0 0 0 15 16 1 0 0 0 0 15 32 1 0 0 0 0 16 17 2 0 0 0 0 16 33 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 34 1 0 0 0 0 22 23 1 0 0 0 0 22 35 1 0 0 0 0 22 36 1 0 0 0 0 23 24 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 24 25 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 25 42 1 0 0 0 0 25 43 1 0 0 0 0 M END > (185) 183 > (185) C18H18Cl2N4O > (185) 377.2724 > (185) FGFR-P183 > (185) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 24 > (185) FGFR-1 Tyrosine Kinase > (185) 4480 > (185) BINDDB > (185) <2007 > (185) P > (185) TRAIN $$$$ csChFnd70/04170815452D 47 50 0 0 0 0 0 0 0 0999 V2000 3.6240 9.3010 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6592 7.5034 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6472 7.5905 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2091 10.1933 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7598 9.2226 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2675 12.0249 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4307 11.7893 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8410 12.4997 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.3362 10.0459 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9330 9.0182 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8465 12.8352 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9515 14.7530 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9781 15.6688 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0756 17.4565 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1473 18.3390 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1220 17.4390 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0167 15.6516 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9756 14.5249 3.5246 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8897 14.5636 -3.5097 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.1327 6.7191 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0827 4.9301 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4122 4.0269 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2429 1.1011 1.0607 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8845 1.2829 -0.8072 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6292 2.2261 -0.8181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7706 3.8451 1.8524 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0259 2.9018 1.8633 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4106 9.9994 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0847 12.7736 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3164 8.7695 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9599 9.7303 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7111 7.7900 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0962 18.1669 -2.7399 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2239 19.7369 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1789 18.1356 2.7894 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1536 4.2713 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4718 4.7670 -0.7667 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.4291 1.0685 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1834 0.3609 1.8118 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0391 0.0000 -1.3790 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9441 2.0231 -1.5583 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0864 2.3556 -2.1489 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5697 1.4859 -0.0670 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7110 3.1049 2.6035 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6159 5.1279 2.4241 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0856 3.6421 1.1123 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5689 2.7724 3.1940 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 28 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 29 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 16 1 0 0 0 0 15 34 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 25 1 0 0 0 0 22 26 1 0 0 0 0 22 37 1 0 0 0 0 23 24 1 0 0 0 0 23 27 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 25 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 25 42 1 0 0 0 0 25 43 1 0 0 0 0 26 27 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 27 46 1 0 0 0 0 27 47 1 0 0 0 0 M END > (186) 184 > (186) C20H20Cl2N4O > (186) 403.3102 > (186) FGFR-P184 > (186) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 25 > (186) FGFR-1 Tyrosine Kinase > (186) 6800 > (186) BINDDB > (186) <2007 > (186) P > (186) TRAIN $$$$ Structure3 csChFnd70/04170815452D 38 40 0 0 0 0 0 0 0 0999 V2000 1.2057 8.9102 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2219 7.1237 -0.0264 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2288 7.2103 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7809 9.7967 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3218 8.8322 -0.0182 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8390 11.6168 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9823 11.3827 -0.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3837 12.0887 -0.0317 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8884 9.6503 -0.0294 N 0 0 3 0 0 0 0 0 0 0 0 0 7.4752 8.6291 -0.0493 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4080 12.4220 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5123 14.3278 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5388 15.2379 -1.5417 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6356 17.0142 -1.5240 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7069 17.8912 0.0255 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6817 16.9969 1.5664 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5771 15.2207 1.5669 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5363 14.1010 3.5024 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4509 14.1396 -3.4876 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7050 6.3444 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6553 4.5666 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9952 3.6691 -0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3011 1.7220 -0.0294 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1355 1.2208 1.5329 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 9.6041 0.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6635 12.3608 0.0251 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8561 8.3820 -1.3781 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4955 9.3367 0.6061 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2546 7.4085 0.6089 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6561 17.7202 -2.7227 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7830 19.2804 0.0322 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7383 17.6891 2.7719 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7195 3.9119 -0.0395 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2795 4.0222 1.1398 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2582 4.0352 -1.1529 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0698 1.0557 -0.1371 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1136 1.3838 -1.1234 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3701 0.0000 1.6129 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 25 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 26 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 15 31 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 M END > (187) 185 > (187) C16H14Cl2N4O2 > (187) 365.2182 > (187) FGFR-P185 > (187) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 26 > (187) FGFR-1 Tyrosine Kinase > (187) 1660 > (187) BINDDB > (187) <2007 > (187) P > (187) TRAIN $$$$ csChFnd70/04170815452D 53 56 0 0 0 0 0 0 0 0999 V2000 3.9315 13.6667 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9668 11.8689 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9547 11.9560 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5167 14.5589 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0674 13.5882 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5751 16.3906 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7384 16.1551 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1487 16.8655 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.6439 14.4116 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 10.2408 13.3838 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1542 17.2010 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2592 19.1188 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2857 20.0347 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3832 21.8224 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4549 22.7050 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4296 21.8049 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3244 20.0175 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2833 18.8907 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.1973 18.9295 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4403 11.0846 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3903 9.2955 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7196 8.3923 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0274 6.4329 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2828 5.4895 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2308 1.1615 1.1290 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9561 2.6599 0.2866 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5782 3.6083 -0.0321 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9090 3.1167 1.2404 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6326 0.2623 1.4019 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3075 0.7091 0.1847 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7181 14.3650 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3922 17.1394 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6241 13.1352 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2676 14.0959 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0189 12.1555 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4038 22.5328 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5315 24.1029 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4866 22.5015 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4613 8.6367 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9994 8.7476 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9779 8.7607 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7476 6.0774 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7693 6.0645 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5624 5.8449 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5408 5.8580 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7413 0.8394 -0.1486 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1625 0.7794 2.1203 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4644 2.9843 1.5709 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0187 -0.6900 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4645 3.4484 2.5401 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1084 3.8091 0.9601 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1248 0.0000 0.4931 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7330 0.3739 -1.1203 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 31 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 32 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 33 1 0 0 0 0 10 34 1 0 0 0 0 10 35 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 36 1 0 0 0 0 15 16 1 0 0 0 0 15 37 1 0 0 0 0 16 17 2 0 0 0 0 16 38 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 27 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 28 1 0 0 0 0 25 29 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 30 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 28 1 0 0 0 0 28 50 1 0 0 0 0 28 51 1 0 0 0 0 29 30 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 M END > (191) 189 > (191) C21H23Cl2N5O2 > (191) 448.351 > (191) FGFR-P189 > (191) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 30 > (191) FGFR-1 Tyrosine Kinase > (191) 1410 > (191) BINDDB > (191) <2007 > (191) P > (191) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7q csChFnd70/04170815452D 63 66 0 0 0 0 0 0 0 0999 V2000 9.9001 4.0144 2.3596 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9334 6.3848 0.8900 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3306 7.1670 0.8643 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2412 4.7099 2.3920 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9496 6.3285 1.6241 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8657 3.8177 3.1774 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2647 4.5444 3.1793 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0063 6.2245 2.3719 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5839 6.8779 2.3696 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1643 4.8604 1.6236 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3358 7.0504 1.6316 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0607 8.7304 0.8282 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8019 3.6372 3.9924 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0622 3.0547 6.4756 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4277 3.9044 5.7255 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7878 2.5174 3.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4261 1.6756 3.7926 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0663 1.9411 5.5128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6762 5.3014 6.9361 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.2365 2.1836 0.8674 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.3215 7.2108 0.1352 N 0 0 3 0 0 0 0 0 0 0 0 0 13.9591 6.4711 0.2128 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0165 6.7791 0.4469 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7591 3.9698 0.2002 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1431 4.6985 0.1241 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4014 7.5100 0.3711 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1986 5.0080 0.3650 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7896 4.2895 0.4392 O 0 0 0 0 0 0 0 0 0 0 0 0 18.8821 2.4580 0.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 20.7617 1.8910 0.4505 C 0 0 0 0 0 0 0 0 0 0 0 0 21.4481 2.2946 2.1618 N 0 0 0 0 0 0 0 0 0 0 0 0 23.0333 1.3274 2.5002 C 0 0 0 0 0 0 0 0 0 0 0 0 23.4275 1.3683 4.4257 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7333 4.1502 2.3557 C 0 0 0 0 0 0 0 0 0 0 0 0 22.8737 4.7947 0.8899 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1436 2.7808 2.9464 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1600 8.4066 0.2644 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0764 2.5794 3.7672 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7218 8.5536 -0.5192 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0211 9.3985 1.4873 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2346 9.4890 0.9186 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7713 3.2603 7.8168 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6403 0.8087 3.0467 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2798 6.1056 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1570 8.3009 -0.4464 H 0 0 0 0 0 0 0 0 0 0 0 0 18.1377 7.5865 0.5752 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9021 2.5910 0.1365 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0225 3.8899 -0.0039 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2598 8.8889 0.4343 H 0 0 0 0 0 0 0 0 0 0 0 0 18.1674 1.9005 1.4153 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3285 2.0224 -0.8628 H 0 0 0 0 0 0 0 0 0 0 0 0 20.8459 0.5109 0.2273 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5073 2.5676 -0.5231 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8678 0.0000 2.0855 H 0 0 0 0 0 0 0 0 0 0 0 0 24.0942 1.9083 1.7941 H 0 0 0 0 0 0 0 0 0 0 0 0 22.4178 0.6932 5.1233 H 0 0 0 0 0 0 0 0 0 0 0 0 24.6578 0.7428 4.6638 H 0 0 0 0 0 0 0 0 0 0 0 0 23.4875 2.6978 4.8619 H 0 0 0 0 0 0 0 0 0 0 0 0 20.5029 4.8181 2.3183 H 0 0 0 0 0 0 0 0 0 0 0 0 22.3629 4.4001 3.5815 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1975 6.1399 1.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 24.0485 4.0335 0.8430 H 0 0 0 0 0 0 0 0 0 0 0 0 22.1878 4.6698 -0.3248 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 38 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 12 41 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 42 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 43 1 0 0 0 0 18 44 1 0 0 0 0 21 22 1 0 0 0 0 21 45 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 46 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 25 48 1 0 0 0 0 26 49 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 35 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 M END > (20) 18 > (20) C27H28Cl2N4O2 > (20) 511.4498 > (20) FGFR-P18 > (20) 1,6-naphthyridin-2(1H)-one deriv. 7q > (20) FGFR-1 Tyrosine Kinase > (20) 130 > (20) BINDDB > (20) <2007 > (20) P > (20) TRAIN $$$$ csChFnd70/04170815452D 57 60 0 0 0 0 0 0 0 0999 V2000 3.9366 15.9989 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9720 14.2011 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9598 14.2882 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5219 16.8912 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0726 15.9205 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5804 18.7228 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7436 18.4873 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1539 19.1977 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.6491 16.7438 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 10.2460 15.7160 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1594 19.5332 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2644 21.4511 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2909 22.3670 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3884 24.1546 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4601 25.0372 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4348 24.1371 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3296 22.3497 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2885 21.2228 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2025 21.2616 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4456 13.4168 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3955 11.6276 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7248 10.7245 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0326 8.7650 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2879 7.8218 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2597 3.4995 1.1098 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9619 4.9924 0.2865 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5834 5.9405 -0.0321 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9173 5.4497 1.2363 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3044 3.0422 0.1600 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6383 2.5515 1.4285 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9338 0.6702 1.4150 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7233 16.6973 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3975 19.4716 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6293 15.4674 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2728 16.4281 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0240 14.4877 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4090 24.8650 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5367 26.4352 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4917 24.8338 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4665 10.9688 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0046 11.0798 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9830 11.0929 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7528 8.4097 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7745 8.3966 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5676 8.1771 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5460 8.1902 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7418 3.1883 -0.1815 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2217 3.1262 2.0752 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4798 5.3036 1.5778 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3658 -0.6789 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4688 5.7662 2.5384 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1102 6.1565 0.9635 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1116 2.3354 0.4329 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7528 2.7257 -1.1421 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8622 0.3320 2.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7129 0.0000 1.6539 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4452 0.2827 0.1561 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 34 1 0 0 0 0 10 35 1 0 0 0 0 10 36 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 37 1 0 0 0 0 15 16 1 0 0 0 0 15 38 1 0 0 0 0 16 17 2 0 0 0 0 16 39 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 27 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 28 1 0 0 0 0 25 30 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 26 29 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 M END > (192) 190 > (192) C22H26Cl2N6O > (192) 461.393 > (192) FGFR-P190 > (192) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 31 > (192) FGFR-1 Tyrosine Kinase > (192) 380 > (192) BINDDB > (192) <2007 > (192) P > (192) TRAIN $$$$ csChFnd70/04170815452D 60 63 0 0 0 0 0 0 0 0999 V2000 8.2802 15.3170 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3155 13.5192 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 8.3034 13.6062 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8654 16.2093 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4161 15.2386 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9239 18.0409 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0872 17.8054 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4976 18.5158 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9926 16.0619 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 14.5896 15.0341 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5029 18.8513 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6079 20.7691 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6344 21.6850 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7319 23.4728 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8036 24.3554 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7783 23.4553 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6731 21.6679 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6320 20.5410 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.5460 20.5797 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.7891 12.7348 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7390 10.9457 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0684 10.0425 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3762 8.0831 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6315 7.1398 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9391 5.1804 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7348 1.5005 -0.2204 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4936 2.4108 -0.3438 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0659 5.0401 -1.2904 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3074 4.1297 -1.1670 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 2.2659 -1.4886 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8617 1.3603 -1.4781 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2640 4.2745 -0.0222 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0668 16.0154 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7410 18.7897 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9729 14.7855 -1.3869 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6165 15.7462 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3677 13.8058 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7525 24.1832 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8802 25.7533 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8353 24.1519 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8100 10.2869 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3482 10.3978 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3266 10.4109 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0964 7.7277 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1181 7.7146 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9111 7.4952 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8896 7.5083 -1.1634 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6595 4.8250 -1.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6811 4.8118 1.1120 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8962 0.1239 -0.4956 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2102 1.6631 1.0816 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3728 1.8707 0.6213 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0344 2.2185 -1.6350 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5908 4.8774 -2.5923 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9045 6.4167 -1.0153 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7666 4.3221 0.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4281 4.6700 -2.1323 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2826 1.4558 -0.1928 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9528 -2.4283 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0596 0.0000 -1.8056 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 33 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 34 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 35 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 38 1 0 0 0 0 15 16 1 0 0 0 0 15 39 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 32 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 32 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 32 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 30 31 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 31 60 1 0 0 0 0 M END > (193) 191 > (193) C23H28Cl2N6O > (193) 475.4198 > (193) FGFR-P191 > (193) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 32 > (193) FGFR-1 Tyrosine Kinase > (193) 320 > (193) BINDDB > (193) <2007 > (193) P > (193) TRAIN $$$$ csChFnd70/04170815452D 63 66 0 0 0 0 0 0 0 0999 V2000 5.3738 18.8994 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4091 17.1016 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.3970 17.1887 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9590 19.7917 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5097 18.8209 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0174 21.6234 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1807 21.3877 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5910 22.0982 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 10.0862 19.6443 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6831 18.6165 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5964 22.4338 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7014 24.3516 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7280 25.2675 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8255 27.0552 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8972 27.9377 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8719 27.0377 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7666 25.2502 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7255 24.1234 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6396 24.1622 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8826 16.3173 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8326 14.5282 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1619 13.6250 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4697 11.6654 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7250 10.7222 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0326 8.7627 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2879 7.8194 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3044 3.0398 0.1569 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9619 4.9901 0.2834 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9173 5.4474 1.2332 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2597 3.4972 1.1067 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5834 5.9382 -0.0353 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6383 2.5490 1.4253 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9338 0.6679 1.4119 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1603 19.5977 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8345 22.3722 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0664 18.3679 -1.3869 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7099 19.3286 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4611 17.3882 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8461 27.7656 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9738 29.3357 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9288 27.7343 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9035 13.8694 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4417 13.9803 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4201 13.9934 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1900 11.3101 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2116 11.2970 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0046 11.0775 1.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9831 11.0906 -1.1634 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7531 8.4074 -1.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7745 8.3943 1.1120 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5676 8.1747 1.1408 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5460 8.1879 -1.1666 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1116 2.3331 0.4297 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7529 2.7234 -1.1452 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3634 -0.6820 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4798 5.3013 1.5747 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4688 5.7639 2.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1102 6.1542 0.9603 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7418 3.1859 -0.1846 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2217 3.1238 2.0721 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3621 0.2676 0.1261 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9267 0.3402 2.3624 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7318 0.0000 1.7371 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 26 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 32 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 28 31 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 30 32 1 0 0 0 0 30 59 1 0 0 0 0 30 60 1 0 0 0 0 32 33 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 M END > (194) 192 > (194) C24H30Cl2N6O > (194) 489.4466 > (194) FGFR-P192 > (194) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 33 > (194) FGFR-1 Tyrosine Kinase > (194) 240 > (194) BINDDB > (194) <2007 > (194) P > (194) TRAIN $$$$ csChFnd70/04170815452D 43 46 0 0 0 0 0 0 0 0999 V2000 1.2134 12.0670 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2487 10.2692 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2366 10.3563 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7986 12.9592 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3493 11.9885 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8570 14.7909 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0203 14.5553 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4307 15.2657 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9258 12.8119 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5227 11.7841 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4360 15.6012 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5410 17.5191 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5676 18.4350 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6651 20.2227 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7368 21.1053 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7115 20.2052 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6062 18.4178 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5651 17.2910 3.5247 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4792 17.3297 -3.5098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7222 9.4849 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6722 7.6958 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0016 6.7926 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3047 4.8626 -0.0294 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5953 2.1815 1.4893 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8552 1.3806 -0.0984 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8197 2.3703 -1.5918 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3152 3.9570 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5499 4.0564 -1.5170 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.7653 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6741 15.5396 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9061 11.5355 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5496 12.4962 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3008 10.5558 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6857 20.9331 -2.7400 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8134 22.5032 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7684 20.9018 2.7895 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7431 7.0370 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2813 7.1479 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2598 7.1610 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6160 1.4412 2.6774 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0772 0.0000 -0.1680 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0215 1.7562 -2.8337 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1084 4.6237 2.7299 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 15 35 1 0 0 0 0 16 17 2 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 28 1 0 0 0 0 23 27 2 0 0 0 0 24 25 2 0 0 0 0 24 27 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 26 28 2 0 0 0 0 26 42 1 0 0 0 0 27 43 1 0 0 0 0 M END > (195) 193 > (195) C20H15Cl2N5O > (195) 412.2774 > (195) FGFR-P193 > (195) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 34 > (195) FGFR-1 Tyrosine Kinase > (195) 3210 > (195) BINDDB > (195) <2007 > (195) P > (195) TRAIN $$$$ csChFnd70/04170815452D 43 46 0 0 0 0 0 0 0 0999 V2000 1.2134 12.0681 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2486 10.2704 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2366 10.3575 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7985 12.9604 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3492 11.9897 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8569 14.7920 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0202 14.5565 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4304 15.2669 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9257 12.8130 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5224 11.7853 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4359 15.6023 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5409 17.5201 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5675 18.4360 -1.5515 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6650 20.2236 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7367 21.1061 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7114 20.2061 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6061 18.4187 1.5769 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5650 17.2919 3.5246 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4791 17.3307 -3.5097 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7221 9.4861 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6721 7.6970 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 1.0016 6.7939 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3047 4.8641 -0.0294 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7037 2.1981 -1.5359 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8530 1.3822 0.0524 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4598 3.9592 1.5088 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4240 3.9726 -1.5858 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7258 2.2703 1.5071 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.7665 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6741 15.5408 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9058 11.5366 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5493 12.4973 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3005 10.5570 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6856 20.9340 -2.7399 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8133 22.5041 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7683 20.9027 2.7894 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7430 7.0382 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2813 7.1492 1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2598 7.1623 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8096 1.4636 -2.7230 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0705 0.0000 0.1024 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3626 4.6431 2.7265 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3017 4.6448 -2.8078 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 15 35 1 0 0 0 0 16 17 2 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 26 2 0 0 0 0 23 27 1 0 0 0 0 24 25 1 0 0 0 0 24 27 2 0 0 0 0 24 40 1 0 0 0 0 25 28 2 0 0 0 0 25 41 1 0 0 0 0 26 28 1 0 0 0 0 26 42 1 0 0 0 0 27 43 1 0 0 0 0 M END > (196) 194 > (196) C20H15Cl2N5O > (196) 412.2774 > (196) FGFR-P194 > (196) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 35 > (196) FGFR-1 Tyrosine Kinase > (196) 3150 > (196) BINDDB > (196) <2007 > (196) P > (196) TRAIN $$$$ csChFnd70/04170815452D 46 49 0 0 0 0 0 0 0 0999 V2000 5.9820 11.1642 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0174 9.3663 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 6.0052 9.4535 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5673 12.0565 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1180 11.0858 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6257 13.8883 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7891 13.6527 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1995 14.3631 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 10.6946 11.9091 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2916 10.8813 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2048 14.6986 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3098 16.6166 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3364 17.5325 -1.5516 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4339 19.3203 -1.5338 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5056 20.2029 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4803 19.3028 1.5765 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3750 17.5153 1.5770 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3339 16.3884 3.5249 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.2480 16.4272 -3.5100 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4909 8.5819 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4409 6.7927 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7702 5.8896 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0779 3.9300 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3594 3.0008 -0.0188 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9964 1.7960 -1.2939 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4115 0.9475 -1.2718 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2466 1.3453 0.0376 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7003 2.5653 1.2691 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2221 3.3420 1.2114 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7685 11.8626 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4427 14.6370 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6749 10.6326 -1.3870 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3185 11.5935 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0696 9.6530 0.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4545 20.0307 -2.7401 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5822 21.6010 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5372 19.9995 2.7896 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5118 6.1339 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0498 6.2449 1.1471 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0284 6.2580 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7982 3.5747 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8198 3.5616 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9349 1.5187 -2.2951 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0922 0.0000 -2.2519 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.7100 0.0946 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7997 2.8828 2.2932 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 10 34 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 35 1 0 0 0 0 15 16 1 0 0 0 0 15 36 1 0 0 0 0 16 17 2 0 0 0 0 16 37 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 29 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 26 27 2 0 0 0 0 26 44 1 0 0 0 0 27 28 1 0 0 0 0 27 45 1 0 0 0 0 28 29 2 0 0 0 0 28 46 1 0 0 0 0 M END > (197) 195 > (197) C21H17Cl2N5O > (197) 426.3042 > (197) FGFR-P195 > (197) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 36 > (197) FGFR-1 Tyrosine Kinase > (197) 6530 > (197) BINDDB > (197) <2007 > (197) P > (197) TRAIN $$$$ csChFnd70/04170815452D 49 51 0 0 0 0 0 0 0 0999 V2000 4.1360 15.3286 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1711 13.5309 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1592 13.6180 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7211 16.2208 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2717 15.2501 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7796 18.0523 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9426 17.8168 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3528 18.5271 -0.0319 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8481 16.0734 -0.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 10.4449 15.0457 -0.0496 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3584 18.8626 -0.0009 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4634 20.7803 0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4900 21.6961 -1.5514 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5875 23.4837 -1.5336 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6592 24.3662 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6339 23.4662 1.5763 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5286 21.6789 1.5768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4875 20.5522 3.5244 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4016 20.5909 -3.5095 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6447 12.7467 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5947 10.9577 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 3.9242 10.0546 -0.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2319 8.0952 -0.0296 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4874 7.1521 -0.0187 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7950 5.1927 -0.0327 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0505 4.2494 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8150 1.7566 -0.0525 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3536 2.3197 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2264 -0.0292 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9227 16.0269 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5967 18.8010 0.0253 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8282 14.7971 -1.3868 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4716 15.7578 0.6099 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2229 13.8175 0.6127 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6081 24.1941 -2.7398 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7358 25.7641 0.0324 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6908 24.1628 2.7893 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6656 10.2989 -0.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2040 10.4099 1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1825 10.4230 -1.1602 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9522 7.7399 -1.1921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9738 7.7268 1.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7671 7.5074 1.1438 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7456 7.5205 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5154 4.8374 -1.1952 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5369 4.8243 1.1119 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3302 4.6048 1.1407 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3086 4.6180 -1.1665 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2590 0.0000 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 32 1 0 0 0 0 10 33 1 0 0 0 0 10 34 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 35 1 0 0 0 0 15 16 1 0 0 0 0 15 36 1 0 0 0 0 16 17 2 0 0 0 0 16 37 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 25 26 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 26 28 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 28 2 0 0 0 0 28 29 1 0 0 0 0 29 49 1 0 0 0 0 M END > (198) 196 > (198) C20H20Cl2N4O3 > (198) 435.309 > (198) FGFR-P196 > (198) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 37 > (198) FGFR-1 Tyrosine Kinase > (198) 580 > (198) BINDDB > (198) <2007 > (198) P > (198) TRAIN $$$$ csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.8869 7.8189 -0.6062 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5345 6.3126 -0.2139 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9187 6.3428 -0.4119 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2571 8.6129 -0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6101 7.7982 -0.4014 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2954 10.1945 -0.8112 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0432 10.0389 -0.5849 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2627 10.6736 -0.5755 O 0 0 0 0 0 0 0 0 0 0 0 0 7.9733 8.5325 -0.3952 N 0 0 3 0 0 0 0 0 0 0 0 0 9.3666 7.6693 -0.1795 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6609 10.9177 -0.8043 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7389 12.5747 -1.0140 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8688 13.1836 -2.4605 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9411 14.7292 -2.6481 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8850 15.6731 -1.4060 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7568 15.0769 0.0309 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6764 13.5335 0.2337 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5059 12.7878 2.0373 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9401 12.0007 -4.0207 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2145 5.6127 -0.2209 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1832 4.0664 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8018 3.3153 0.1051 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0674 1.8285 0.3577 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2741 1.1259 -0.3391 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6404 1.8648 -0.4671 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5893 4.0152 0.8102 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2260 3.2700 0.9344 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8290 8.4029 -0.7658 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2633 10.8231 -0.9699 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7975 7.3064 -1.2730 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2050 8.3765 0.3775 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1342 6.6828 0.5174 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0421 15.2018 -3.7670 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9420 16.8809 -1.5588 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7140 15.8200 0.9960 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1199 3.5019 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2485 0.4560 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1466 0.0000 -0.7878 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5823 1.3155 -1.0118 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7125 5.1408 1.2611 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2815 3.8156 1.4780 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 28 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 29 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 16 1 0 0 0 0 15 34 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 25 1 0 0 0 0 22 26 2 0 0 0 0 23 24 1 0 0 0 0 23 27 2 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 39 1 0 0 0 0 26 27 1 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 M END > (199) 197 > (199) C20H14Cl2N4O > (199) 397.2628 > (199) FGFR-P197 > (199) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 > (199) FGFR-1 Tyrosine Kinase > (199) 460 > (199) BINDDB > (199) <2007 > (199) P > (199) TRAIN $$$$ csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 3.9584 7.9627 -0.6174 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6547 6.4288 -0.2178 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9908 6.4595 -0.4195 N 0 0 0 0 0 0 0 0 0 0 0 0 5.3538 8.7714 -0.6190 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7317 7.9417 -0.4088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3928 10.3822 -0.8261 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1912 10.2237 -0.5957 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4331 10.8700 -0.5861 O 0 0 0 0 0 0 0 0 0 0 0 0 8.1200 8.6895 -0.4025 N 0 0 3 0 0 0 0 0 0 0 0 0 6.7834 11.1187 -0.8191 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8628 12.8062 -1.0326 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9951 13.4262 -2.5058 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0688 15.0003 -2.6968 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0117 15.9615 -1.4319 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8811 15.3544 0.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7992 13.7826 0.2380 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6256 13.0232 2.0748 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.0678 12.2216 -4.0947 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3104 5.7160 -0.2249 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2786 4.1412 -0.0231 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8717 3.3763 0.1070 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0870 1.8622 0.3643 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3159 1.1466 -0.3454 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7074 1.8991 -0.4757 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6369 4.0891 0.8251 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2486 3.3302 0.9516 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5390 7.8104 -0.1829 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1551 7.2918 -1.7460 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8810 8.5575 -0.7799 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3418 11.0224 -0.9877 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1717 15.4816 -3.8363 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0697 17.1916 -1.5875 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8376 16.1112 1.0144 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2325 3.5664 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2715 0.4644 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1861 0.0000 -0.8023 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6666 1.3397 -1.0305 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7624 5.2354 1.2843 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2866 3.8858 1.5052 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3928 8.5306 0.3844 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3022 6.8057 0.5269 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3013 6.5715 -2.3132 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3919 8.2965 -2.4558 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2110 6.6377 -1.5826 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 23 1 0 0 0 0 22 26 2 0 0 0 0 22 35 1 0 0 0 0 23 24 2 0 0 0 0 23 36 1 0 0 0 0 24 37 1 0 0 0 0 25 26 1 0 0 0 0 25 38 1 0 0 0 0 26 39 1 0 0 0 0 27 28 1 0 0 0 0 27 40 1 0 0 0 0 27 41 1 0 0 0 0 28 42 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 M END > (200) 198 > (200) C21H16Cl2N4O > (200) 411.2896 > (200) FGFR-P198 > (200) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 39 > (200) FGFR-1 Tyrosine Kinase > (200) 210 > (200) BINDDB > (200) <2007 > (200) P > (200) TRAIN $$$$ csChFnd70/04170815452D 40 43 0 0 0 0 0 0 0 0999 V2000 3.7715 6.6484 -0.5629 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4104 5.1417 -0.1993 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8029 5.1756 -0.3831 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1375 7.4384 -0.5642 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4861 6.6236 -0.3729 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1761 9.0163 -0.7524 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9153 8.8566 -0.5444 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1311 9.4876 -0.5367 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8450 7.3540 -0.3679 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5374 9.7356 -0.7459 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6155 11.3885 -0.9400 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7382 12.0083 -2.3764 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8106 13.5500 -2.5494 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7618 14.4792 -1.3028 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6409 13.8720 0.1240 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5604 12.3324 0.3123 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3991 11.5729 2.1033 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.8002 10.8441 -3.9421 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0944 4.4455 -0.2060 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0628 2.9029 -0.0226 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2339 6.4907 -0.1680 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6860 2.1544 0.1047 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0424 0.6245 0.3088 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5146 0.7091 -0.4618 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4680 2.8446 0.8075 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1275 2.0578 0.9060 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2182 0.0000 -0.3439 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7172 7.2326 -0.7111 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1474 9.6448 -0.8996 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9060 14.0311 -3.6604 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8189 15.6841 -1.4443 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6038 14.6036 1.0927 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9960 2.3394 0.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6569 6.1381 -1.2630 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0728 7.1898 0.3884 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0049 5.5020 0.5193 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0058 0.3832 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4524 0.1610 -1.0048 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5666 3.9655 1.2645 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1582 2.5600 1.4381 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 28 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 29 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 21 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 30 1 0 0 0 0 14 15 1 0 0 0 0 14 31 1 0 0 0 0 15 16 2 0 0 0 0 15 32 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 22 1 0 0 0 0 20 33 1 0 0 0 0 21 34 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 24 2 0 0 0 0 22 25 1 0 0 0 0 23 27 2 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 27 1 0 0 0 0 24 38 1 0 0 0 0 25 26 2 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 M END > (201) 199 > (201) C19H13Cl2N5O > (201) 398.2506 > (201) FGFR-P199 > (201) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 40 > (201) FGFR-1 Tyrosine Kinase > (201) 150 > (201) BINDDB > (201) <2007 > (201) P > (201) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7r csChFnd70/04170815452D 66 69 0 0 0 0 0 0 0 0999 V2000 10.6142 10.1229 1.1117 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1022 12.1652 -0.4559 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6067 13.0297 -0.8993 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0457 10.9145 0.7263 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0428 12.4068 -0.3061 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4775 10.2424 1.3534 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9740 11.0565 0.9451 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0161 12.6013 -0.1283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6818 13.3315 -0.4961 O 0 0 0 0 0 0 0 0 0 0 0 0 12.0603 10.7640 0.5182 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5252 13.2178 -0.7108 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5502 14.7639 -1.7835 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3142 10.3794 1.5842 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1116 10.3014 3.7454 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6598 10.9378 3.1569 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3947 9.1860 0.6127 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8482 8.5599 1.2161 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2100 9.1135 2.7793 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7895 12.4285 4.3716 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.1928 8.4905 -1.3502 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.6712 12.7760 -1.0413 N 0 0 3 0 0 0 0 0 0 0 0 0 15.1705 11.8264 -0.7515 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1809 11.7281 -0.1028 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6087 9.1092 -0.5494 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1288 10.0448 -0.8349 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7022 12.6658 -0.3878 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1366 9.9482 -0.1796 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5934 9.0259 0.1007 O 0 0 0 0 0 0 0 0 0 0 0 0 19.4546 7.1981 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 21.2109 6.3878 0.3510 C 0 0 0 0 0 0 0 0 0 0 0 0 21.0622 4.4308 0.2449 C 0 0 0 0 0 0 0 0 0 0 0 0 22.7484 3.6527 0.5803 N 0 0 0 0 0 0 0 0 0 0 0 0 22.6008 1.7834 0.7910 C 0 0 0 0 0 0 0 0 0 0 0 0 21.8123 1.3820 2.5460 C 0 0 0 0 0 0 0 0 0 0 0 0 23.9762 4.0845 -0.7862 C 0 0 0 0 0 0 0 0 0 0 0 0 25.8046 3.7221 -0.1626 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6371 8.9846 1.9044 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6581 14.1675 -1.6915 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4674 9.1020 2.1432 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4448 14.3988 -3.1311 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4731 15.5893 -1.4379 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7514 15.4542 -1.5795 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6039 10.7325 4.9625 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1353 7.6361 0.4653 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.6199 3.2452 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7290 13.8609 -1.6513 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3710 12.3803 0.1852 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5753 7.7234 -0.6091 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9392 9.3913 -1.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7370 14.0514 -0.3285 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5344 6.7475 0.9562 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0176 6.8319 -1.2773 H 0 0 0 0 0 0 0 0 0 0 0 0 22.1310 6.8384 -0.6035 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6477 6.7540 1.6299 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1420 3.9802 1.1994 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6252 4.0646 -1.0340 H 0 0 0 0 0 0 0 0 0 0 0 0 21.7817 1.2631 -0.2186 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8719 1.2022 0.7064 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4843 1.8249 2.5733 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8482 0.0000 2.7687 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5428 2.0349 3.5462 H 0 0 0 0 0 0 0 0 0 0 0 0 23.7066 3.3066 -1.9189 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8545 5.4409 -1.1117 H 0 0 0 0 0 0 0 0 0 0 0 0 26.0261 4.3906 1.0476 H 0 0 0 0 0 0 0 0 0 0 0 0 25.9681 2.3445 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 26.7221 4.1727 -1.1196 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 37 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 38 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 39 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 40 1 0 0 0 0 12 41 1 0 0 0 0 12 42 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 43 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 44 1 0 0 0 0 18 45 1 0 0 0 0 21 22 1 0 0 0 0 21 46 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 47 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 31 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 32 35 1 0 0 0 0 33 34 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 34 61 1 0 0 0 0 35 36 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 36 64 1 0 0 0 0 36 65 1 0 0 0 0 36 66 1 0 0 0 0 M END > (21) 19 > (21) C28H30Cl2N4O2 > (21) 525.4766 > (21) FGFR-P19 > (21) 1,6-naphthyridin-2(1H)-one deriv. 7r > (21) FGFR-1 Tyrosine Kinase > (21) 250 > (21) BINDDB > (21) <2007 > (21) P > (21) TRAIN $$$$ 22 csChFnd70/04170815452D 62 66 0 0 0 0 0 0 0 0999 V2000 11.3278 5.2899 -1.2605 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5342 3.5169 -1.4536 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8845 2.6711 -0.6243 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0384 3.6020 0.4050 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8353 5.3799 0.6007 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4779 6.2268 -0.2327 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2692 8.0217 -0.0379 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6477 8.7589 -0.2178 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8405 9.0230 -0.5544 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5931 10.6783 -0.4260 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7696 11.9706 -0.7380 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5433 12.1536 -0.5219 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0613 8.8602 -0.7759 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0321 10.3253 -0.8653 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3323 10.4297 -0.2223 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7424 13.4047 -0.8321 O 0 0 0 0 0 0 0 0 0 0 0 0 13.1382 0.4432 -0.8692 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.7411 14.3249 -2.3366 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6614 16.6361 -4.1260 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8171 14.8497 -5.2089 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8534 13.8842 -3.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7493 16.1740 -5.3834 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6217 15.7283 -2.5638 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4798 18.1332 -4.3897 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4820 18.5629 -3.2440 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5117 19.0187 -5.9003 N 0 0 3 0 0 0 0 0 0 0 0 0 1.3435 20.4988 -6.1609 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1595 7.8668 -0.4219 O 0 0 0 0 0 0 0 0 0 0 0 0 15.3654 2.7692 1.2202 O 0 0 0 0 0 0 0 0 0 0 0 0 16.5019 3.8080 2.2577 C 0 0 0 0 0 0 0 0 0 0 0 0 17.9035 2.6524 3.0653 C 0 0 2 0 0 0 0 0 0 0 0 0 17.0493 1.2254 4.1854 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2947 1.0804 5.7637 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8657 2.9950 6.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0179 3.6932 4.2252 N 0 0 3 0 0 0 0 0 0 0 0 0 18.5297 5.5377 4.1688 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2750 5.9485 -1.9139 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6385 2.7904 -2.2533 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7312 6.1058 1.4006 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2660 8.7473 0.2237 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1139 13.4321 -0.4275 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4805 7.5868 -0.8791 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6452 10.1939 -1.0341 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6819 14.5155 -6.2625 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7354 12.8003 -3.5642 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7359 16.1058 -1.5430 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3083 18.6758 -6.8151 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6064 21.4859 -5.1801 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5551 21.0458 -7.4500 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 20.0655 -6.0466 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1133 4.7941 1.4455 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7589 4.4375 3.2861 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6885 2.0626 2.0446 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7559 1.6241 4.6032 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9929 0.0000 3.4777 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6099 0.6051 6.9086 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4048 0.2549 5.4598 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8857 3.7125 6.7369 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1163 3.0560 6.6701 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2206 5.6955 4.6859 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4399 6.2910 4.9499 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5664 5.9949 2.8288 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 38 1 0 0 0 0 3 4 1 0 0 0 0 3 17 1 0 0 0 0 4 5 2 0 0 0 0 4 29 1 0 0 0 0 5 6 1 0 0 0 0 5 39 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 40 1 0 0 0 0 8 15 2 0 0 0 0 8 28 1 0 0 0 0 9 28 1 0 0 0 0 9 13 1 0 0 0 0 9 10 2 0 0 0 0 10 15 1 0 0 0 0 10 12 1 0 0 0 0 11 12 2 0 0 0 0 11 14 1 0 0 0 0 11 16 1 0 0 0 0 12 41 1 0 0 0 0 13 14 2 0 0 0 0 13 42 1 0 0 0 0 14 43 1 0 0 0 0 16 18 1 0 0 0 0 18 21 1 0 0 0 0 18 23 2 0 0 0 0 19 23 1 0 0 0 0 19 22 2 0 0 0 0 19 24 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 20 44 1 0 0 0 0 21 45 1 0 0 0 0 23 46 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 35 1 0 0 0 0 31 32 1 0 0 0 0 31 53 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 34 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 35 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 35 36 1 0 0 0 0 36 60 1 0 0 0 0 36 61 1 0 0 0 0 36 62 1 0 0 0 0 M END > (3) 1 > (3) C26H26ClN5O4 > (3) 507.9755 > (3) FGFR-P1 > (3) 2-aminobenzoxazole, 22 > (3) FGFR-1 Tyrosine Kinase > (3) 4370 > (3) 2007 17696416 Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors. 2007 > (3) 2007 > (3) P > (3) TEST $$$$ csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 5.1697 8.9726 -0.5630 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8075 7.4668 -0.1993 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2011 7.5007 -0.3831 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5351 9.7624 -0.5642 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8831 8.9479 -0.3729 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5736 11.3394 -0.7525 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3116 11.1800 -0.5444 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5266 11.8107 -0.5363 O 0 0 0 0 0 0 0 0 0 0 0 0 9.2414 9.6781 -0.3678 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9341 12.0584 -0.7459 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0122 13.7105 -0.9401 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1347 14.3299 -2.3757 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2064 15.8709 -2.5489 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1571 16.7997 -1.3031 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0363 16.1929 0.1232 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9570 14.6540 0.3116 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7966 13.8950 2.1020 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.1974 13.1662 -3.9406 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.4922 6.7708 -0.2059 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4607 5.2296 -0.0226 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6295 8.8153 -0.1679 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0823 4.4800 0.1049 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9128 3.0376 -0.4611 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8651 5.1716 0.8081 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5258 4.3886 0.9086 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6173 2.3251 -0.3443 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4385 2.9494 0.3100 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1286 2.1722 0.4037 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1107 0.6949 -0.2265 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1159 9.5566 -0.7112 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5454 11.9675 -0.8996 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3017 16.3517 -3.6594 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2136 18.0040 -1.4446 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9987 16.9242 1.0912 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3933 4.6662 0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0524 8.4628 -1.2624 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4682 9.5142 0.3882 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4009 7.8271 0.5190 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8514 2.4917 -1.0039 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9654 6.2923 1.2639 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5583 4.8919 1.4420 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.2003 -0.0762 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3714 0.7576 -1.4218 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9470 0.0000 0.3381 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 21 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 22 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 26 1 0 0 0 0 23 39 1 0 0 0 0 24 25 2 0 0 0 0 24 40 1 0 0 0 0 25 27 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 42 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 M END > (202) 200 > (202) C20H15Cl2N5O2 > (202) 428.2768 > (202) FGFR-P200 > (202) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 41 > (202) FGFR-1 Tyrosine Kinase > (202) 540 > (202) BINDDB > (202) <2007 > (202) P > (202) TRAIN $$$$ csChFnd70/04170815452D 40 43 0 0 0 0 0 0 0 0999 V2000 3.6629 7.8995 -0.5636 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3472 6.3655 -0.1997 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6947 6.4012 -0.3837 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0526 8.7029 -0.5647 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4243 7.8734 -0.3735 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0920 10.3085 -0.7531 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8785 10.1450 -0.5435 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1154 10.7865 -0.5349 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8069 8.6159 -0.3674 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4769 11.0398 -0.7466 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5567 12.7214 -0.9419 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6804 13.3539 -2.4021 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7538 14.9223 -2.5762 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7054 15.8658 -1.3070 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5834 15.2463 0.1439 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5018 13.6799 0.3333 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3404 12.9049 2.1545 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7426 12.1717 -3.9965 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0085 5.6577 -0.2065 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9762 4.0875 -0.0230 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2197 7.7371 -0.1669 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5802 3.3286 0.1062 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9950 1.1410 -0.3186 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3950 1.8525 -0.4693 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3342 4.0230 0.8199 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9725 3.2333 0.9241 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8410 1.8395 0.3593 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5903 8.4945 -0.7119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0457 10.9485 -0.9003 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8495 15.4133 -3.7058 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7636 17.0916 -1.4493 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5470 15.9891 1.1303 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9252 3.5139 0.0160 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6493 7.3811 -1.2818 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0736 8.4467 0.4004 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9870 6.7298 0.5301 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8396 0.0000 -0.7661 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3346 1.2746 -1.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4343 5.1633 1.2850 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7640 1.4707 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 28 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 29 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 21 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 30 1 0 0 0 0 14 15 1 0 0 0 0 14 31 1 0 0 0 0 15 16 2 0 0 0 0 15 32 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 22 1 0 0 0 0 20 33 1 0 0 0 0 21 34 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 24 1 0 0 0 0 22 25 2 0 0 0 0 23 27 1 0 0 0 0 23 24 2 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 M END > (203) 201 > (203) C19H13Cl2N5O > (203) 398.2506 > (203) FGFR-P201 > (203) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 42 > (203) FGFR-1 Tyrosine Kinase > (203) 190 > (203) BINDDB > (203) <2007 > (203) P > (203) TRAIN $$$$ csChFnd70/04170815452D 43 46 0 0 0 0 0 0 0 0999 V2000 3.6805 7.9375 -0.5663 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3776 6.3960 -0.2007 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7124 6.4318 -0.3855 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0769 8.7447 -0.5674 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4551 7.9112 -0.3753 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1164 10.3579 -0.7567 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9163 10.1937 -0.5461 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1591 10.8382 -0.5374 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8444 8.6573 -0.3692 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5080 11.0927 -0.7502 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5881 12.7824 -0.9464 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7124 13.4179 -2.4137 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7863 14.9939 -2.5886 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7376 15.9419 -1.3133 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6149 15.3194 0.1446 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5331 13.7454 0.3349 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3708 12.9668 2.1648 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7749 12.2300 -4.0156 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0325 5.6849 -0.2075 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0001 4.1071 -0.0231 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5974 3.3445 0.1067 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0046 1.1465 -0.3201 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4113 1.8614 -0.4716 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3454 4.0423 0.8239 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9772 3.2488 0.9286 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8450 1.8483 0.3610 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2639 7.7743 -0.1677 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8699 7.2719 -1.7401 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6027 8.5353 -0.7154 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0651 11.0010 -0.9047 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8824 15.4872 -3.7236 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7962 17.1735 -1.4562 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5785 16.0658 1.1357 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9536 3.5307 0.0161 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8484 0.0000 -0.7697 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3554 1.2807 -1.0306 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4460 5.1880 1.2912 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7821 1.4777 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1219 8.4873 0.4023 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0301 6.7620 0.5326 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0118 6.5588 -2.3101 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1036 8.2841 -2.4404 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9259 6.6148 -1.5903 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 26 1 0 0 0 0 22 23 2 0 0 0 0 22 35 1 0 0 0 0 23 36 1 0 0 0 0 24 25 1 0 0 0 0 24 37 1 0 0 0 0 25 26 2 0 0 0 0 25 38 1 0 0 0 0 27 28 1 0 0 0 0 27 39 1 0 0 0 0 27 40 1 0 0 0 0 28 41 1 0 0 0 0 28 42 1 0 0 0 0 28 43 1 0 0 0 0 M END > (204) 202 > (204) C20H15Cl2N5O > (204) 412.2774 > (204) FGFR-P202 > (204) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 43 > (204) FGFR-1 Tyrosine Kinase > (204) 110 > (204) BINDDB > (204) <2007 > (204) P > (204) TRAIN $$$$ csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 4.3746 7.5418 -0.5847 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9284 6.0891 -0.2063 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4054 6.1180 -0.3974 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6961 8.3077 -0.5863 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0013 7.5220 -0.3872 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7330 9.8333 -0.7824 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3834 9.6830 -0.5666 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5598 10.2949 -0.5588 O 0 0 0 0 0 0 0 0 0 0 0 0 8.3160 8.2302 -0.3822 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0500 10.5307 -0.7759 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1252 12.1289 -0.9787 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2506 12.7156 -2.3739 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3198 14.2063 -2.5555 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2649 15.1171 -1.3578 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1410 14.5426 0.0283 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0646 13.0540 0.2244 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9008 12.3355 1.9643 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3203 11.5743 -3.8782 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6552 5.4140 -0.2130 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6252 3.9226 -0.0213 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2922 3.1980 0.1024 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8194 1.0859 -0.3254 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1369 1.7990 -0.4490 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1232 3.8736 0.7825 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8082 3.1555 0.9031 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6599 7.3978 -0.1736 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6545 1.7639 0.3472 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.8644 0.5007 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3543 8.1049 -0.7387 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7376 10.4393 -0.9355 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4172 14.6617 -3.6346 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3193 16.2821 -1.5056 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0991 15.2596 0.9588 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5285 3.3784 0.0274 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6964 0.0000 -0.7587 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0454 1.2693 -0.9744 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2426 4.9593 1.2168 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8975 3.6821 1.4275 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0753 7.0468 -1.2279 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4686 8.0803 0.3628 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4358 6.4469 0.4996 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 27 1 0 0 0 0 22 23 2 0 0 0 0 22 35 1 0 0 0 0 23 36 1 0 0 0 0 24 25 1 0 0 0 0 24 37 1 0 0 0 0 25 27 2 0 0 0 0 25 38 1 0 0 0 0 26 39 1 0 0 0 0 26 40 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 M END > (205) 203 > (205) C20H13Cl3N4O > (205) 431.7079 > (205) FGFR-P203 > (205) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 44 > (205) FGFR-1 Tyrosine Kinase > (205) 3000 > (205) BINDDB > (205) <2007 > (205) P > (205) TRAIN $$$$ csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.7544 8.3665 -0.5859 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3111 6.9123 -0.2067 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7852 6.9413 -0.3982 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0775 9.1334 -0.5874 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3841 8.3466 -0.3879 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1145 10.6608 -0.7840 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7680 10.5104 -0.5658 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9457 11.1231 -0.5576 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7003 9.0559 -0.3819 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4330 11.3591 -0.7774 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5084 12.9589 -0.9806 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6342 13.5462 -2.3776 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7035 15.0387 -2.5595 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6485 15.9507 -1.3607 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5245 15.3757 0.0272 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4477 13.8853 0.2237 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2835 13.1662 1.9658 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7039 12.4034 -3.8836 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0364 6.2364 -0.2135 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0062 4.7432 -0.0219 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6723 4.0179 0.1014 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5166 2.6173 -0.4511 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5016 4.6938 0.7823 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1848 3.9745 0.9026 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0459 8.2224 -0.1729 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0307 2.5831 0.3462 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1965 1.9034 -0.3273 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9802 0.0000 -1.0866 Br 0 0 0 0 0 0 0 0 0 0 0 0 2.7330 8.9305 -0.7401 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1180 11.2677 -0.9374 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8011 15.4946 -3.6401 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7031 17.1171 -1.5087 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4824 16.0938 0.9588 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9108 4.1982 0.0270 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4261 2.0868 -0.9772 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6211 5.7808 1.2176 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2730 4.5019 1.4277 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4623 7.8715 -1.2286 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8552 8.9055 0.3647 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8212 7.2701 0.5004 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.0231 0.4421 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 25 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 27 2 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 26 2 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 25 40 1 0 0 0 0 26 27 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 M END > (206) 204 > (206) C20H13BrCl2N4O > (206) 476.1589 > (206) FGFR-P204 > (206) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 45 > (206) FGFR-1 Tyrosine Kinase > (206) 2400 > (206) BINDDB > (206) <2007 > (206) P > (206) TRAIN $$$$ csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 5.2384 7.8409 -0.6082 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8935 6.3304 -0.2145 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2704 6.3607 -0.4132 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6126 8.6372 -0.6096 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9694 7.8202 -0.4027 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6509 10.2234 -0.8137 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4067 10.0671 -0.5887 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6297 10.7032 -0.5802 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3363 8.5565 -0.3975 N 0 0 3 0 0 0 0 0 0 0 0 0 8.0202 10.9486 -0.8068 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0986 12.6099 -1.0182 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2293 13.2195 -2.4692 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3013 14.7694 -2.6585 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2440 15.7168 -1.4137 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1150 15.1200 0.0277 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0355 13.5723 0.2322 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8647 12.8259 2.0415 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.3020 12.0323 -4.0327 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.5698 5.6286 -0.2215 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5384 4.0780 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1531 3.3246 0.1054 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9913 1.8701 -0.4684 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9373 4.0266 0.8126 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5704 3.2791 0.9376 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7338 7.6909 -0.1811 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6213 1.1290 -0.3395 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4114 1.8334 0.3599 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9184 1.0209 0.4990 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1776 8.4266 -0.7682 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6160 10.8536 -0.9729 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4029 15.2425 -3.7808 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3008 16.9280 -1.5679 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0713 15.8659 0.9950 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4777 3.5120 0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9357 1.3196 -1.0151 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0608 5.1554 1.2643 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6233 3.8258 1.4836 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1655 7.3261 -1.2776 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5746 8.4003 0.3767 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5008 6.7020 0.5187 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4933 0.0000 -0.7899 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8932 0.3847 1.5554 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.8446 0.4930 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7819 0.2460 -0.4511 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 25 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 26 2 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 27 2 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 25 40 1 0 0 0 0 26 27 1 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 M END > (207) 205 > (207) C21H16Cl2N4O > (207) 411.2896 > (207) FGFR-P205 > (207) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 > (207) FGFR-1 Tyrosine Kinase > (207) 910 > (207) BINDDB > (207) <2007 > (207) P > (207) TRAIN $$$$ csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 6.1029 7.8444 -0.6100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7582 6.3344 -0.2151 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1349 6.3643 -0.4144 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4769 8.6408 -0.6115 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8339 7.8240 -0.4039 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5153 10.2270 -0.8162 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2711 10.0709 -0.5911 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4941 10.7071 -0.5829 O 0 0 0 0 0 0 0 0 0 0 0 0 10.2008 8.5605 -0.3987 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8846 10.9523 -0.8094 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9628 12.6137 -1.0209 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0935 13.2231 -2.4719 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1654 14.7730 -2.6613 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1080 15.7207 -1.4166 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9790 15.1237 0.0249 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8994 13.5763 0.2295 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7288 12.8298 2.0388 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1664 12.0358 -4.0355 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4345 5.6323 -0.2221 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4032 4.0818 -0.0222 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0178 3.3285 0.1065 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5982 7.6951 -0.1811 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4879 1.1293 -0.3402 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2755 1.8295 0.3574 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8566 1.8732 -0.4674 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8035 4.0308 0.8130 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4317 3.2802 0.9383 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2386 3.9671 1.6239 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8577 3.1296 1.7069 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0421 8.4299 -0.7704 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4803 10.8572 -0.9758 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2670 15.2461 -3.7837 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1646 16.9318 -1.5708 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9352 15.8698 0.9920 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3425 3.5158 0.0290 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0304 7.3296 -1.2771 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4389 8.4051 0.3765 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3649 6.7068 0.5193 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3633 0.0000 -0.7909 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2066 1.2448 0.4550 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8020 1.3238 -1.0133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9273 5.1597 1.2647 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.8064 2.2795 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4729 2.8571 0.5670 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0467 2.0864 2.3374 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 25 1 0 0 0 0 21 26 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 25 2 0 0 0 0 23 39 1 0 0 0 0 24 27 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 26 27 1 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (208) 206 > (208) C21H16Cl2N4O2 > (208) 427.289 > (208) FGFR-P206 > (208) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 48 > (208) FGFR-1 Tyrosine Kinase > (208) 370 > (208) BINDDB > (208) <2007 > (208) P > (208) TRAIN $$$$ csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 6.3669 7.8165 -0.6064 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0131 6.3115 -0.2138 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3988 6.3413 -0.4120 N 0 0 0 0 0 0 0 0 0 0 0 0 7.7363 8.6101 -0.6079 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0885 7.7961 -0.4015 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7744 10.1907 -0.8114 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5207 10.0353 -0.5876 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7395 10.6694 -0.5799 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4508 8.5299 -0.3963 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1389 10.9137 -0.8046 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2168 12.5693 -1.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3471 13.1767 -2.4614 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4187 14.7211 -2.6501 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3615 15.6655 -1.4097 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2324 15.0708 0.0267 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1537 13.5286 0.2308 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9835 12.7848 2.0337 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.4197 11.9934 -4.0195 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6940 5.6118 -0.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6629 4.0670 -0.0221 N 0 0 3 0 0 0 0 0 0 0 0 0 6.2800 3.3152 0.1062 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8433 7.6676 -0.1800 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7562 1.1251 -0.3384 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1202 1.8658 -0.4653 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0697 4.0159 0.8110 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7063 3.2737 0.9371 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5457 1.8284 0.3600 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2027 1.0985 0.4842 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0048 1.8898 1.2164 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3097 8.3999 -0.7659 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7429 10.8188 -0.9702 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5200 15.1926 -3.7687 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4183 16.8725 -1.5633 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1887 15.8142 0.9906 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5988 3.5031 0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2738 7.3038 -1.2724 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6812 8.3749 0.3758 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6110 6.6825 0.5177 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6302 0.0000 -0.7877 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0624 1.3183 -1.0095 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1946 5.1409 1.2607 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7633 3.8206 1.4805 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3387 2.1651 2.3669 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7620 2.9260 0.6011 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.1820 1.2396 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 27 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 43 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (209) 207 > (209) C21H16Cl2N4O2 > (209) 427.289 > (209) FGFR-P207 > (209) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 49 > (209) FGFR-1 Tyrosine Kinase > (209) 410 > (209) BINDDB > (209) <2007 > (209) P > (209) TRAIN $$$$ csChFnd70/04170815452D 36 38 0 0 0 0 0 0 0 0999 V2000 1.3130 6.7891 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0025 5.1940 -0.0236 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3336 5.2723 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7183 7.5798 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0926 6.7184 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7709 9.2041 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5754 8.9933 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8260 9.6224 -0.0283 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4908 7.4476 -0.0262 N 0 0 3 0 0 0 0 0 0 0 0 0 6.9060 6.5357 -0.0440 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1710 9.9217 -0.0008 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2650 11.6219 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2890 12.4338 -1.3757 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3763 14.0188 -1.3600 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4403 14.8014 0.0224 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4174 14.0034 1.3974 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3232 12.4187 1.3980 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2856 11.4200 3.1249 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 11.4539 -3.1120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6497 4.5001 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6044 2.9072 -0.0225 N 0 0 3 0 0 0 0 0 0 0 0 0 1.2415 2.1710 -0.0134 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1924 0.4396 -0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0549 2.9017 0.0018 O 0 0 0 0 0 0 0 0 0 0 0 0 0.2372 7.4085 0.0192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7225 9.8685 0.0223 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2456 6.3151 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8167 7.1664 0.5408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7085 5.4469 0.5433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3950 14.6486 -2.4295 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5088 16.0407 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4681 14.6211 2.4728 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5537 2.3226 -0.0347 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7807 0.0000 0.9927 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0556 -0.0130 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7611 0.0109 -1.0530 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 25 1 0 0 0 0 2 20 2 0 0 0 0 2 5 1 0 0 0 0 3 20 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 11 2 0 0 0 0 6 26 1 0 0 0 0 7 9 1 0 0 0 0 7 11 1 0 0 0 0 7 8 2 0 0 0 0 9 10 1 0 0 0 0 10 27 1 0 0 0 0 10 28 1 0 0 0 0 10 29 1 0 0 0 0 11 12 1 0 0 0 0 12 17 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 13 19 1 0 0 0 0 14 15 2 0 0 0 0 14 30 1 0 0 0 0 15 16 1 0 0 0 0 15 31 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 2 0 0 0 0 23 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 M END > (210) 208 > (210) C16H12Cl2N4O2 > (210) 363.2024 > (210) FGFR-P208 > (210) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 > (210) FGFR-1 Tyrosine Kinase > (210) 5800 > (210) BINDDB > (210) <2007 > (210) P > (210) TRAIN $$$$ csChFnd70/04170815452D 42 45 0 0 0 0 0 0 0 0999 V2000 3.9243 7.8448 -0.6100 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5798 6.3346 -0.2152 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9564 6.3645 -0.4145 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2985 8.6413 -0.6116 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6555 7.8244 -0.4039 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3369 10.2277 -0.8162 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0930 10.0716 -0.5911 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3161 10.7079 -0.5834 O 0 0 0 0 0 0 0 0 0 0 0 0 8.0227 8.5609 -0.3987 N 0 0 3 0 0 0 0 0 0 0 0 0 6.7063 10.9531 -0.8095 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7844 12.6147 -1.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9155 13.2237 -2.4729 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9875 14.7737 -2.6629 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9298 15.7218 -1.4183 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8006 15.1254 0.0235 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7210 13.5777 0.2286 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5498 12.8319 2.0383 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9887 12.0356 -4.0363 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2561 5.6325 -0.2222 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2247 4.0817 -0.0222 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8392 3.3284 0.1065 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4203 7.6955 -0.1811 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3089 1.1291 -0.3407 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6781 1.8729 -0.4674 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6247 4.0307 0.8131 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0966 1.8292 0.3574 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2529 3.2801 0.9384 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0599 3.9667 1.6250 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8633 8.4303 -0.7705 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3017 10.8579 -0.9759 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0894 15.2464 -3.7856 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9866 16.9331 -1.5729 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7565 15.8719 0.9906 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1641 3.5158 0.0290 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8525 7.3300 -1.2773 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2611 8.4055 0.3765 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1870 6.7070 0.5194 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1840 0.0000 -0.7921 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6237 1.3232 -1.0131 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7485 5.1598 1.2650 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0273 1.2448 0.4544 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7829 2.7022 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 35 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 26 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 27 1 0 0 0 0 25 40 1 0 0 0 0 26 27 2 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 M END > (211) 209 > (211) C20H14Cl2N4O2 > (211) 413.2622 > (211) FGFR-P209 > (211) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 50 > (211) FGFR-1 Tyrosine Kinase > (211) 180 > (211) BINDDB > (211) <2007 > (211) P > (211) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7s csChFnd70/04170815452D 66 70 0 0 0 0 0 0 0 0999 V2000 10.6715 7.0620 1.6796 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3717 9.0073 0.2076 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9882 10.0798 -0.1330 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2077 8.0672 1.3943 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3710 9.6165 0.4638 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5809 7.5532 2.0215 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1836 8.5743 1.7129 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3975 10.1728 0.7436 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1584 11.0869 0.4648 O 0 0 0 0 0 0 0 0 0 0 0 0 12.1741 7.5580 1.0873 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9596 10.6359 0.1589 N 0 0 3 0 0 0 0 0 0 0 0 0 8.1567 12.2379 -0.8091 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4656 8.0659 2.3545 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3169 8.1121 4.5702 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9201 8.5906 3.9796 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3828 7.0665 1.3336 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7827 6.5970 1.9395 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2525 7.1156 3.5543 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2540 9.8412 5.2564 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.0452 6.4156 -0.6940 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.9926 9.4577 -0.3822 N 0 0 3 0 0 0 0 0 0 0 0 0 15.3670 8.3132 -0.1964 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3671 7.8053 0.2869 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4447 5.4275 -0.1371 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0879 6.5556 -0.3200 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0119 8.9353 0.1043 C 0 0 0 0 0 0 0 0 0 0 0 0 18.0861 6.0497 0.1698 C 0 0 0 0 0 0 0 0 0 0 0 0 19.4215 4.9378 0.3492 O 0 0 0 0 0 0 0 0 0 0 0 0 19.0393 3.1474 0.2140 C 0 0 0 0 0 0 0 0 0 0 0 0 20.6895 2.1057 0.4487 C 0 0 0 0 0 0 0 0 0 0 0 0 23.6681 1.7909 4.2490 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9166 1.3521 2.4859 C 0 0 0 0 0 0 0 0 0 0 0 0 20.0825 2.1318 3.4998 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8340 2.5707 5.2628 C 0 0 0 0 0 0 0 0 0 0 0 0 21.3924 2.4205 2.1715 N 0 0 0 0 0 0 0 0 0 0 0 0 22.3581 1.5021 5.5773 N 0 0 0 0 0 0 0 0 0 0 0 0 23.0611 1.8169 7.3000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5674 5.8771 2.3938 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1658 11.2547 -0.8490 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4437 6.3707 2.7338 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9777 11.9832 -2.1743 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1996 13.1646 -0.3777 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4392 12.7575 -0.5954 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8931 8.5172 5.8276 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9434 5.8235 1.1507 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.7449 4.0220 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1731 10.5656 -0.9233 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6456 8.2886 0.5258 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2270 4.0604 -0.2280 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8099 6.0711 -0.5586 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2310 10.3022 0.1949 H 0 0 0 0 0 0 0 0 0 0 0 0 18.1172 2.7908 1.2055 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4944 2.8804 -1.0480 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4057 0.7425 0.3024 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6274 2.4934 -0.5160 H 0 0 0 0 0 0 0 0 0 0 0 0 24.7769 0.9739 4.5008 H 0 0 0 0 0 0 0 0 0 0 0 0 24.0634 3.1342 4.2670 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8740 1.6008 1.4949 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5534 0.0000 2.4564 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6871 0.7886 3.4818 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9737 2.9489 3.2480 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1972 3.9227 5.2924 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8765 2.3219 6.2538 H 0 0 0 0 0 0 0 0 0 0 0 0 23.5051 3.1420 7.3879 H 0 0 0 0 0 0 0 0 0 0 0 0 22.0649 1.5940 8.2585 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1347 0.9486 7.5319 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 38 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 39 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 40 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 41 1 0 0 0 0 12 42 1 0 0 0 0 12 43 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 44 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 45 1 0 0 0 0 18 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 48 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 52 1 0 0 0 0 29 53 1 0 0 0 0 30 35 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 31 36 1 0 0 0 0 31 32 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 35 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 35 1 0 0 0 0 33 34 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 34 36 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 36 37 1 0 0 0 0 37 64 1 0 0 0 0 37 65 1 0 0 0 0 37 66 1 0 0 0 0 M END > (22) 20 > (22) C28H29Cl2N5O2 > (22) 538.4754 > (22) FGFR-P20 > (22) 1,6-naphthyridin-2(1H)-one deriv. 7s > (22) FGFR-1 Tyrosine Kinase > (22) 210 > (22) BINDDB > (22) <2007 > (22) P > (22) TRAIN $$$$ csChFnd70/04170815452D 42 45 0 0 0 0 0 0 0 0999 V2000 4.2664 7.8165 -0.6064 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9127 6.3116 -0.2138 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2983 6.3414 -0.4120 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6358 8.6102 -0.6079 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9881 7.7961 -0.4015 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6739 10.1908 -0.8114 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4202 10.0354 -0.5876 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6391 10.6695 -0.5799 O 0 0 0 0 0 0 0 0 0 0 0 0 8.3503 8.5300 -0.3963 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0385 10.9138 -0.8046 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1164 12.5695 -1.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2467 13.1768 -2.4615 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3183 14.7213 -2.6501 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2611 15.6657 -1.4098 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1320 15.0710 0.0267 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0533 13.5287 0.2308 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8831 12.7850 2.0338 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3193 11.9936 -4.0195 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.5935 5.6119 -0.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5624 4.0670 -0.0221 N 0 0 3 0 0 0 0 0 0 0 0 0 4.1795 3.3152 0.1062 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7430 7.6676 -0.1800 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6556 1.1251 -0.3384 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0197 1.8659 -0.4653 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9692 4.0159 0.8110 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6058 3.2737 0.9371 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4452 1.8285 0.3600 C 0 0 0 0 0 0 0 0 0 0 0 0 0.1022 1.0985 0.4842 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2092 8.4000 -0.7659 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6424 10.8189 -0.9702 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4196 15.1928 -3.7687 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3179 16.8727 -1.5634 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0884 15.8144 0.9906 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4984 3.5031 0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1734 7.3039 -1.2724 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5808 8.3750 0.3758 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5106 6.6826 0.5177 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5297 0.0000 -0.7877 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9619 1.3183 -1.0095 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0941 5.1410 1.2607 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6628 3.8206 1.4806 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5098 1.3965 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 29 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 30 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 31 1 0 0 0 0 14 15 1 0 0 0 0 14 32 1 0 0 0 0 15 16 2 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 35 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 27 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 26 27 2 0 0 0 0 26 41 1 0 0 0 0 27 28 1 0 0 0 0 28 42 1 0 0 0 0 M END > (212) 210 > (212) C20H14Cl2N4O2 > (212) 413.2622 > (212) FGFR-P210 > (212) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 51 > (212) FGFR-1 Tyrosine Kinase > (212) 150 > (212) BINDDB > (212) <2007 > (212) P > (212) TRAIN $$$$ csChFnd70/04170815452D 48 51 0 0 0 0 0 0 0 0999 V2000 5.3833 8.9374 -0.6072 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0325 7.4306 -0.2142 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4153 7.4605 -0.4126 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7542 9.7318 -0.6088 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1079 8.9169 -0.4021 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7924 11.3142 -0.8125 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5417 11.1586 -0.5884 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7619 11.7933 -0.5808 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4717 9.6515 -0.3969 N 0 0 3 0 0 0 0 0 0 0 0 0 8.1584 12.0379 -0.8057 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2364 13.6954 -1.0166 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3669 14.3033 -2.4644 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4385 15.8495 -2.6534 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3813 16.7950 -1.4116 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2520 16.1996 0.0264 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1732 14.6557 0.2307 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0027 13.9110 2.0356 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.4397 13.1187 -4.0242 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7119 6.7303 -0.2212 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6807 5.1838 -0.0221 N 0 0 3 0 0 0 0 0 0 0 0 0 5.2964 4.4311 0.1064 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8659 8.7883 -0.1802 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7711 2.2385 -0.3388 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1365 2.9800 -0.4660 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0848 5.1324 0.8118 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7199 4.3894 0.9379 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4027 5.1532 1.6974 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5592 2.9427 0.3604 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2146 2.2120 0.4848 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1310 0.7225 -0.1296 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3250 9.5213 -0.7670 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7597 11.9428 -0.9715 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5399 16.3214 -3.7731 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4381 18.0031 -1.5655 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2082 16.9439 0.9912 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6177 4.6192 0.0287 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2968 8.4240 -1.2739 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7046 9.4964 0.3761 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6333 7.8021 0.5183 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6448 1.1122 -0.7887 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0796 2.4318 -1.0107 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2099 6.2588 1.2619 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4156 4.8935 2.9002 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4879 6.3707 1.5396 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3518 4.7479 1.2014 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3758 0.7616 -1.3349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9533 0.0000 0.4329 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.2697 0.0448 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 31 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 32 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 33 1 0 0 0 0 14 15 1 0 0 0 0 14 34 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 28 1 0 0 0 0 23 24 2 0 0 0 0 23 40 1 0 0 0 0 24 41 1 0 0 0 0 25 26 1 0 0 0 0 25 42 1 0 0 0 0 26 28 2 0 0 0 0 26 27 1 0 0 0 0 27 43 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 30 46 1 0 0 0 0 30 47 1 0 0 0 0 30 48 1 0 0 0 0 M END > (213) 211 > (213) C22H18Cl2N4O2 > (213) 441.3158 > (213) FGFR-P211 > (213) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 53 > (213) FGFR-1 Tyrosine Kinase > (213) 450 > (213) BINDDB > (213) <2007 > (213) P > (213) TRAIN $$$$ csChFnd70/04170815452D 49 52 0 0 0 0 0 0 0 0999 V2000 6.0861 9.9395 -0.6110 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7350 8.4332 -0.2154 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1181 8.4628 -0.4152 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4568 10.7340 -0.6126 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8104 9.9193 -0.4045 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4952 12.3163 -0.8175 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2441 12.1612 -0.5896 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4640 12.7961 -0.5801 O 0 0 0 0 0 0 0 0 0 0 0 0 10.1741 10.6542 -0.3983 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8610 13.0400 -0.8108 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9390 14.6973 -1.0231 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0702 15.3041 -2.4710 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1425 16.8502 -2.6613 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0851 17.7965 -1.4203 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9552 17.2023 0.0182 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8752 15.6586 0.2236 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7034 14.9154 2.0290 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1431 14.1183 -4.0300 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4145 7.7329 -0.2225 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3832 6.1861 -0.0221 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0014 5.4347 0.1061 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5682 9.7910 -0.1809 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8413 3.9840 -0.4660 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7898 6.1362 0.8117 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4197 5.3900 0.9389 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2591 3.9431 0.3617 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2324 6.0784 1.6246 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8531 5.2457 1.7111 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4705 3.2394 -0.3378 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3118 1.8221 -0.9034 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8663 1.1249 -0.7376 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0278 10.5234 -0.7718 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4626 12.9447 -0.9776 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2444 17.3212 -3.7813 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1425 19.0046 -1.5751 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9110 17.9473 0.9825 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3203 5.6215 0.0295 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0000 9.4270 -1.2744 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4066 10.4992 0.3761 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3353 8.8047 0.5172 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7843 3.4359 -1.0111 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9148 7.2625 1.2615 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1916 3.3623 0.4617 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.9233 2.2833 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4664 4.9734 0.5749 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0409 4.2052 2.3408 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8938 0.0000 -1.2361 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5879 1.0369 0.4579 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0147 1.8057 -1.3081 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 34 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 29 2 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 25 26 2 0 0 0 0 25 27 1 0 0 0 0 26 29 1 0 0 0 0 26 43 1 0 0 0 0 27 28 1 0 0 0 0 28 44 1 0 0 0 0 28 45 1 0 0 0 0 28 46 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 31 47 1 0 0 0 0 31 48 1 0 0 0 0 31 49 1 0 0 0 0 M END > (214) 212 > (214) C22H18Cl2N4O3 > (214) 457.3152 > (214) FGFR-P212 > (214) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 54 > (214) FGFR-1 Tyrosine Kinase > (214) 430 > (214) BINDDB > (214) <2007 > (214) P > (214) TRAIN $$$$ csChFnd70/04170815452D 50 53 0 0 0 0 0 0 0 0999 V2000 8.8797 7.8578 -0.6129 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5377 6.3463 -0.2161 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9118 6.3762 -0.4164 N 0 0 0 0 0 0 0 0 0 0 0 0 10.2552 8.6550 -0.6145 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6135 7.8375 -0.4058 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2936 10.2426 -0.8201 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0522 10.0865 -0.5934 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2763 10.7234 -0.5852 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9817 8.5746 -0.4005 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6643 10.9688 -0.8132 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7426 12.6319 -1.0252 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8737 13.2416 -2.4778 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9456 14.7930 -2.6677 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8881 15.7418 -1.4218 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7587 15.1446 0.0212 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6791 13.5955 0.2262 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5080 12.8486 2.0375 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.9467 12.0528 -4.0427 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.2125 5.6437 -0.2232 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1811 4.0916 -0.0228 N 0 0 3 0 0 0 0 0 0 0 0 0 8.7941 3.3373 0.1056 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3805 7.7085 -0.1824 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6339 1.8800 -0.4700 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5806 4.0401 0.8121 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1986 3.2826 0.9371 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0480 1.8216 0.3495 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2652 1.1298 -0.3466 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8979 4.0257 1.6834 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0317 5.2967 2.1938 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5637 3.2940 1.7978 O 0 0 0 0 0 0 0 0 0 0 0 0 2.3354 4.0933 2.5450 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9221 3.0900 2.5667 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8179 8.4438 -0.7742 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2576 10.8734 -0.9806 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0475 15.2664 -3.7913 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9447 16.9542 -1.5763 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7147 15.8916 0.9892 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1214 3.5251 0.0290 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8133 7.3425 -1.2794 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2221 8.4192 0.3756 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1469 6.7193 0.5188 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5822 1.3324 -1.0157 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7043 5.1701 1.2648 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9805 1.2314 0.4438 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1461 0.0000 -0.8009 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6654 4.3646 3.7036 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0900 5.1366 1.9318 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6900 3.1276 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5920 2.8187 1.4081 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1674 2.0466 3.1799 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 33 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 34 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 35 1 0 0 0 0 14 15 1 0 0 0 0 14 36 1 0 0 0 0 15 16 2 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 38 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 27 2 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 25 26 2 0 0 0 0 25 28 1 0 0 0 0 26 27 1 0 0 0 0 26 44 1 0 0 0 0 27 45 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 31 1 0 0 0 0 31 32 1 0 0 0 0 31 46 1 0 0 0 0 31 47 1 0 0 0 0 32 48 1 0 0 0 0 32 49 1 0 0 0 0 32 50 1 0 0 0 0 M END > (215) 213 > (215) C23H18Cl2N4O3 > (215) 469.3262 > (215) FGFR-P213 > (215) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 55 > (215) FGFR-1 Tyrosine Kinase > (215) 1500 > (215) BINDDB > (215) <2007 > (215) P > (215) TRAIN $$$$ csChFnd70/04170815452D 59 62 0 0 0 0 0 0 0 0999 V2000 10.7976 14.4240 -0.6903 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8110 12.7096 -0.2434 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8337 12.7439 -0.4690 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3571 15.3278 -0.6919 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8971 14.4005 -0.4570 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4007 17.1281 -0.9236 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5285 16.9507 -0.6682 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9166 17.6727 -0.6586 O 0 0 0 0 0 0 0 0 0 0 0 0 15.4486 15.2362 -0.4511 N 0 0 3 0 0 0 0 0 0 0 0 0 13.9548 17.9511 -0.9157 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0438 19.8369 -1.1557 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1922 20.5287 -2.8025 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2739 22.2878 -3.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2088 23.3632 -1.6046 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0624 22.6858 0.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9721 20.9292 0.2636 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7783 20.0820 2.3171 Cl 0 0 0 0 0 0 0 0 0 0 0 0 14.2746 19.1812 -4.5772 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.3086 11.9130 -0.2514 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2730 10.1531 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7006 9.2981 0.1196 C 0 0 0 0 0 0 0 0 0 0 0 0 17.0347 14.2537 -0.2055 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5171 7.6471 -0.5317 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3207 10.0947 0.9223 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7693 9.2463 1.0642 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9621 6.8059 -0.3853 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5888 7.6054 0.4085 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8942 6.6832 0.5663 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8542 5.6697 2.2495 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1337 4.7335 2.4097 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7011 2.8083 4.4829 O 0 0 0 0 0 0 0 0 0 0 0 0 4.0943 3.7351 4.0676 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3170 3.7689 5.0229 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7533 1.8792 6.0993 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0647 0.9053 6.3498 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5935 15.0887 -0.8719 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2260 17.8434 -1.1043 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3892 22.8249 -4.2911 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2733 24.7379 -1.7795 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0128 23.5324 1.1293 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3391 9.5107 0.0319 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5248 13.8397 -1.4501 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9892 15.0589 0.4276 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7703 13.1313 0.5887 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5889 7.0222 -1.1522 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4608 11.3759 1.4350 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6943 9.8669 1.6838 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8168 5.5245 -0.8966 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8518 7.6181 0.5595 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7393 5.8038 -0.5120 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8966 4.7349 2.2562 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0091 6.5491 3.3277 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0914 5.6682 2.4030 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9787 3.8539 1.3315 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8179 0.9702 6.0809 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9306 2.7845 7.1525 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.8143 6.3682 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8874 0.0000 5.2966 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1039 0.2078 7.5631 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 36 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 37 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 27 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 32 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 2 0 0 0 0 34 35 1 0 0 0 0 34 55 1 0 0 0 0 34 56 1 0 0 0 0 35 57 1 0 0 0 0 35 58 1 0 0 0 0 35 59 1 0 0 0 0 M END > (217) 215 > (217) C26H24Cl2N4O3 > (217) 511.4066 > (217) FGFR-P215 > (217) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 57 > (217) FGFR-1 Tyrosine Kinase > (217) 2600 > (217) BINDDB > (217) <2007 > (217) P > (217) TRAIN $$$$ csChFnd70/04170815452D 50 53 0 0 0 0 0 0 0 0999 V2000 7.8599 9.0990 -0.6180 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5567 7.5653 -0.2179 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8924 7.5956 -0.4199 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2553 9.9077 -0.6195 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6334 9.0782 -0.4092 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2942 11.5186 -0.8269 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0929 11.3604 -0.5968 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3348 12.0067 -0.5877 O 0 0 0 0 0 0 0 0 0 0 0 0 12.0216 9.8262 -0.4029 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6848 12.2553 -0.8200 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7642 13.9427 -1.0347 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8970 14.5616 -2.5084 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9699 16.1357 -2.7007 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9117 17.0981 -1.4364 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7807 16.4919 0.0276 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7000 14.9201 0.2353 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5267 14.1620 2.0728 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.9709 13.3558 -4.0964 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.2123 6.8522 -0.2250 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1806 5.2778 -0.0225 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7714 4.5116 0.1083 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4409 8.9474 -0.1824 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6085 3.0346 -0.4742 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5379 5.2257 0.8265 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1484 4.4693 0.9550 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2183 2.2797 -0.3448 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9848 2.9964 0.3670 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6164 2.2521 0.4943 O 0 0 0 0 0 0 0 0 0 0 0 0 2.3955 3.0586 1.2405 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9586 2.0455 1.2748 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2498 0.6879 2.2355 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7824 9.6936 -0.7807 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2431 12.1586 -0.9887 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0731 16.6163 -3.8405 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9692 18.3281 -1.5930 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7365 17.2496 1.0098 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1344 4.7031 0.0291 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8802 8.5772 -1.2958 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2945 9.6678 0.3847 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2040 7.9430 0.5279 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5686 2.4766 -1.0288 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6652 6.3723 1.2848 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1876 5.0264 1.5094 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0901 1.1329 -0.8024 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7361 3.3401 2.4129 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1475 4.1142 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.6964 1.7513 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6773 1.6803 0.1099 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5852 0.9974 3.3017 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3171 0.0000 2.2766 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 34 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 26 2 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 25 27 2 0 0 0 0 25 43 1 0 0 0 0 26 27 1 0 0 0 0 26 44 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 45 1 0 0 0 0 29 46 1 0 0 0 0 30 31 1 0 0 0 0 30 47 1 0 0 0 0 30 48 1 0 0 0 0 31 49 1 0 0 0 0 31 50 1 0 0 0 0 M END > (218) 216 > (218) C22H19Cl2N5O2 > (218) 456.3304 > (218) FGFR-P216 > (218) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 58 > (218) FGFR-1 Tyrosine Kinase > (218) 55 > (218) BINDDB > (218) <2007 > (218) P > (218) TRAIN $$$$ csChFnd70/04170815452D 56 59 0 0 0 0 0 0 0 0999 V2000 9.0076 11.6491 -0.6231 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7266 10.1028 -0.2197 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0404 10.1334 -0.4233 N 0 0 0 0 0 0 0 0 0 0 0 0 10.4147 12.4646 -0.6246 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8041 11.6281 -0.4126 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4538 14.0888 -0.8337 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2756 13.9293 -0.6017 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5277 14.5809 -0.5925 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2037 12.3823 -0.4062 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8559 14.8316 -0.8267 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9359 16.5328 -1.0432 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0698 17.1569 -2.5290 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1433 18.7440 -2.7229 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0846 19.7143 -1.4482 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9525 19.1031 0.0278 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8711 17.5183 0.2372 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6964 16.7539 2.0899 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.1443 15.9411 -4.1301 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.3712 9.3839 -0.2269 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3392 7.7964 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9183 7.0239 0.1092 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6347 11.4963 -0.1839 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7541 5.5348 -0.4781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6746 7.7439 0.8333 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2738 6.9813 0.9629 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3525 4.7736 -0.3477 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1089 5.4963 0.3700 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7291 4.7458 0.4984 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4982 5.5590 1.2508 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0495 4.5376 1.2853 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3430 3.1687 2.2539 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9739 2.1589 2.3142 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3237 0.7493 3.3312 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9212 12.2487 -0.7871 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3939 14.7341 -0.9969 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2473 19.2285 -3.8721 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1426 20.9544 -1.6062 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9080 19.8669 1.0182 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3009 7.2170 0.0293 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0776 11.1231 -1.3065 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4953 12.2228 0.3879 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3959 10.4836 0.5323 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7222 4.9721 -1.0373 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8030 8.9000 1.2954 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3051 7.5430 1.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2231 3.6174 -0.8090 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8415 5.8428 2.4327 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2481 6.6233 0.6180 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0830 5.1938 1.7658 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7659 4.1693 0.1108 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2808 2.5813 1.8759 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.7986 2.8017 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6829 1.7741 1.1468 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3077 0.0000 3.3758 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2975 0.1095 2.8436 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6147 1.1341 4.4985 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 36 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 26 2 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 25 27 2 0 0 0 0 25 45 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 47 1 0 0 0 0 29 48 1 0 0 0 0 30 31 1 0 0 0 0 30 49 1 0 0 0 0 30 50 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 32 33 1 0 0 0 0 32 52 1 0 0 0 0 32 53 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 M END > (219) 217 > (219) C24H23Cl2N5O2 > (219) 484.384 > (219) FGFR-P217 > (219) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 59 > (219) FGFR-1 Tyrosine Kinase > (219) 66 > (219) BINDDB > (219) <2007 > (219) P > (219) TRAIN $$$$ csChFnd70/04170815452D 56 59 0 0 0 0 0 0 0 0999 V2000 10.0146 11.8032 -0.6925 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0363 10.0847 -0.2442 N 0 0 0 0 0 0 0 0 0 0 0 0 10.0510 10.1188 -0.4704 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5782 12.7095 -0.6941 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1224 11.7799 -0.4585 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6218 14.5145 -0.9265 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7578 14.3372 -0.6686 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1493 15.0613 -0.6585 O 0 0 0 0 0 0 0 0 0 0 0 0 14.6778 12.6180 -0.4514 N 0 0 3 0 0 0 0 0 0 0 0 0 13.1799 15.3400 -0.9187 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2689 17.2307 -1.1593 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4177 17.9242 -2.8106 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4993 19.6878 -3.0260 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4341 20.7661 -1.6094 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2873 20.0869 0.0309 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1969 18.3258 0.2636 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0027 17.4764 2.3225 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.5005 16.5731 -4.5898 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.5300 9.2858 -0.2522 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4944 7.5217 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9154 6.6632 0.1213 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2681 11.6334 -0.2044 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7329 5.0081 -0.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5333 7.4634 0.9261 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9764 6.6158 1.0701 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1753 4.1623 -0.3864 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7932 4.9654 0.4112 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2599 4.1314 0.5539 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8918 5.0351 1.3899 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2818 3.8999 1.4283 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8559 2.8697 4.3149 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6081 2.3788 2.5048 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2130 1.1129 2.3306 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8073 12.4696 -0.8747 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4439 15.2317 -1.1078 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6150 20.2263 -4.3032 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4985 22.1444 -1.7849 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2379 20.9359 1.1315 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5632 6.8778 0.0326 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7603 11.2187 -1.4519 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2246 12.4407 0.4310 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0027 10.5079 0.5915 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8088 4.3829 -1.1527 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6760 8.7481 1.4395 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8999 7.2400 1.6912 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0316 2.8774 -0.8990 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2734 5.3504 2.7036 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6139 6.2179 0.6868 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2077 4.6293 1.9623 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9667 3.4907 0.1231 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7025 3.5158 4.7866 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0953 1.7195 5.0832 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9540 3.7381 4.4182 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1167 0.7042 0.9911 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4872 0.0000 3.1408 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6954 2.7303 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 36 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 26 2 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 25 27 2 0 0 0 0 25 45 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 47 1 0 0 0 0 29 48 1 0 0 0 0 30 32 1 0 0 0 0 30 49 1 0 0 0 0 30 50 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 31 53 1 0 0 0 0 32 33 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 M END > (220) 218 > (220) C24H23Cl2N5O2 > (220) 484.384 > (220) FGFR-P218 > (220) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 60 > (220) FGFR-1 Tyrosine Kinase > (220) 34 > (220) BINDDB > (220) <2007 > (220) P > (220) TRAIN $$$$ csChFnd70/04170815452D 59 62 0 0 0 0 0 0 0 0999 V2000 13.1725 9.1109 -0.6906 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1861 7.3970 -0.2435 N 0 0 0 0 0 0 0 0 0 0 0 0 13.2088 7.4309 -0.4692 N 0 0 0 0 0 0 0 0 0 0 0 0 14.7320 10.0146 -0.6923 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2719 9.0875 -0.4573 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7754 11.8147 -0.9240 C 0 0 0 0 0 0 0 0 0 0 0 0 17.9029 11.6380 -0.6669 C 0 0 0 0 0 0 0 0 0 0 0 0 19.2907 12.3602 -0.6567 O 0 0 0 0 0 0 0 0 0 0 0 0 17.8232 9.9234 -0.4502 N 0 0 3 0 0 0 0 0 0 0 0 0 16.3293 12.6381 -0.9163 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4181 14.5237 -1.1562 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5664 15.2154 -2.8031 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6479 16.9743 -3.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5829 18.0497 -1.6051 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4365 17.3723 0.0308 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3463 15.6159 0.2629 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1526 14.7688 2.3163 Cl 0 0 0 0 0 0 0 0 0 0 0 0 16.6490 13.8679 -4.5776 Cl 0 0 0 0 0 0 0 0 0 0 0 0 14.6839 6.6001 -0.2515 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6484 4.8407 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 13.0736 3.9845 0.1210 C 0 0 0 0 0 0 0 0 0 0 0 0 19.4092 8.9414 -0.2038 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8916 2.3341 -0.5299 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6952 4.7825 0.9236 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1424 3.9373 1.0672 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3381 1.4904 -0.3853 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9596 2.2914 0.4101 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4305 1.4596 0.5524 O 0 0 0 0 0 0 0 0 0 0 0 0 7.0662 2.3609 1.3863 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4604 1.2288 1.4245 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 2.1938 2.3173 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4581 1.1068 2.3541 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1271 1.8583 3.4602 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7996 0.8082 0.6114 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9685 9.7753 -0.8724 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6007 12.5300 -1.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7632 17.5113 -4.2916 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6471 19.4243 -1.7802 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3871 18.2190 1.1285 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7142 4.1985 0.0325 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9001 8.5279 -1.4480 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3632 9.7466 0.4299 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1445 7.8190 0.5899 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9646 1.7105 -1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8375 6.0639 1.4357 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0689 4.5598 1.6867 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1947 0.2090 -0.8966 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4468 2.6753 2.6964 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7890 3.5404 0.6850 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0797 0.9144 0.1146 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7376 0.0492 2.1258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3804 2.5082 3.6273 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7225 3.3732 1.6161 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7737 3.1221 2.9725 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.0278 3.4644 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6199 1.9825 4.7648 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7812 0.1690 -0.1553 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6581 0.0000 0.6759 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4705 2.0340 0.0204 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 35 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 36 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 37 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 27 2 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 48 1 0 0 0 0 29 49 1 0 0 0 0 30 31 1 0 0 0 0 30 50 1 0 0 0 0 30 51 1 0 0 0 0 31 32 1 0 0 0 0 31 52 1 0 0 0 0 31 53 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 M END > (221) 219 > (221) C25H25Cl2N5O2 > (221) 498.4108 > (221) FGFR-P219 > (221) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 61 > (221) FGFR-1 Tyrosine Kinase > (221) 33 > (221) BINDDB > (221) <2007 > (221) P > (221) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7t csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 10.0694 10.4101 2.7355 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2181 12.3955 0.8428 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6453 13.2041 0.6119 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4362 11.1475 2.5776 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2193 12.5819 1.4873 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0131 10.4779 3.4894 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4396 11.2377 3.2970 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2587 12.7234 2.1561 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8612 13.4053 1.9799 O 0 0 0 0 0 0 0 0 0 0 0 0 11.3785 11.0480 1.8786 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6324 13.3387 1.3010 N 0 0 3 0 0 0 0 0 0 0 0 0 6.4350 14.8254 0.1637 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9282 10.5618 4.2362 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1157 10.5548 6.7352 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5264 11.1905 5.8665 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8961 9.2991 3.4914 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4891 8.6745 4.3739 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1017 9.2982 5.9924 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7970 12.7673 6.8010 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3793 8.5158 1.4598 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.6506 13.0063 -0.0251 N 0 0 3 0 0 0 0 0 0 0 0 0 14.2089 12.1135 0.0713 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2837 12.1296 0.2713 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7558 9.4496 0.1485 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2180 10.3293 0.0540 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7471 13.0114 0.1769 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2911 10.3474 0.2607 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8050 9.4800 0.3530 O 0 0 0 0 0 0 0 0 0 0 0 0 18.7173 7.6463 0.3361 C 0 0 0 0 0 0 0 0 0 0 0 0 20.5334 6.9024 0.4488 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4396 4.9389 0.4305 C 0 0 0 0 0 0 0 0 0 0 0 0 25.0153 3.9606 -0.8039 C 0 0 0 0 0 0 0 0 0 0 0 0 23.9683 1.6835 1.0372 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1337 2.3601 0.8306 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1806 4.6372 -1.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 22.1832 4.2248 0.5387 N 0 0 0 0 0 0 0 0 0 0 0 0 24.9659 2.0959 -0.5118 N 0 0 0 0 0 0 0 0 0 0 0 0 26.7095 1.3817 -0.4036 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2559 9.3165 3.5689 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5319 14.2988 -0.2333 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1668 9.3813 4.3256 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1193 14.3863 -1.1282 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4060 15.6458 0.6422 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6328 15.5503 0.1305 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8031 11.0400 7.9970 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6893 7.6973 3.7990 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.8055 6.6770 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5723 14.0520 -0.6985 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4799 12.8277 0.3586 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7627 8.0621 0.1403 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0226 9.6302 -0.0329 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7417 14.3990 0.1846 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9633 7.2048 1.4305 H 0 0 0 0 0 0 0 0 0 0 0 0 18.1108 7.2189 -0.8516 H 0 0 0 0 0 0 0 0 0 0 0 0 21.2874 7.3440 -0.6456 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1400 7.3297 1.6365 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6855 4.4975 1.5249 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8329 4.5116 -0.7571 H 0 0 0 0 0 0 0 0 0 0 0 0 25.7471 4.2322 -1.9666 H 0 0 0 0 0 0 0 0 0 0 0 0 25.6245 4.5886 0.2896 H 0 0 0 0 0 0 0 0 0 0 0 0 24.5657 2.2858 2.1515 H 0 0 0 0 0 0 0 0 0 0 0 0 23.9369 0.2950 1.2169 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5244 1.7320 -0.2627 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4018 2.0885 1.9934 H 0 0 0 0 0 0 0 0 0 0 0 0 23.2121 6.0257 -1.1899 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5832 4.0350 -2.1248 H 0 0 0 0 0 0 0 0 0 0 0 0 27.3956 1.9842 0.6579 H 0 0 0 0 0 0 0 0 0 0 0 0 26.6353 0.0000 -0.1873 H 0 0 0 0 0 0 0 0 0 0 0 0 27.3910 1.6307 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 39 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 40 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 41 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 42 1 0 0 0 0 12 43 1 0 0 0 0 12 44 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 45 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 46 1 0 0 0 0 18 47 1 0 0 0 0 21 22 1 0 0 0 0 21 48 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 49 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 31 36 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 32 37 1 0 0 0 0 32 35 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 37 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 36 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 37 38 1 0 0 0 0 38 67 1 0 0 0 0 38 68 1 0 0 0 0 38 69 1 0 0 0 0 M END > (23) 21 > (23) C29H31Cl2N5O2 > (23) 552.5022 > (23) FGFR-P21 > (23) 1,6-naphthyridin-2(1H)-one deriv. 7t > (23) FGFR-1 Tyrosine Kinase > (23) 120 > (23) BINDDB > (23) <2007 > (23) P > (23) TRAIN $$$$ csChFnd70/04170815452D 62 65 0 0 0 0 0 0 0 0999 V2000 7.8868 9.8755 3.7272 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4906 12.8650 1.9538 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7283 10.5204 2.6464 N 0 0 0 0 0 0 0 0 0 0 0 0 9.4572 10.7653 3.9529 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7300 12.3118 3.0139 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7479 10.1390 5.0931 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4998 12.6540 4.2752 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8400 13.4760 4.4231 O 0 0 0 0 0 0 0 0 0 0 0 0 11.2475 13.2206 3.1985 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2583 11.0544 5.2691 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6358 10.4325 6.4542 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6484 10.9551 8.1861 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9360 10.3701 9.2841 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2112 9.2688 8.6706 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2065 8.7464 6.9552 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9222 9.3159 5.8452 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9130 8.6509 3.6953 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.0496 12.3378 8.9584 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.0296 11.9806 1.7836 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7719 12.5986 0.6678 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2768 11.6224 0.3577 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5090 14.8234 2.2139 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7014 12.4499 0.0774 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3653 9.8259 0.3219 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 11.4854 -0.2291 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3091 9.6958 -0.2585 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8801 8.8626 0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9611 7.1030 -0.0161 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3790 6.1933 -0.3338 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7247 4.2403 -0.3188 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2342 3.6994 1.4347 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9713 1.8287 1.6752 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0104 1.3990 3.6109 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0375 4.1880 1.8026 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2225 3.4534 0.3918 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6292 8.6909 4.4277 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5454 8.9567 5.8149 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9474 10.7738 10.6246 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2150 8.8151 9.5346 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2061 7.8868 6.4841 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9263 13.7099 0.0998 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0335 15.9212 2.9660 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8867 14.9948 1.9500 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8016 14.7471 0.9932 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6318 13.8482 0.0997 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5891 9.1797 0.5335 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.1305 -0.4404 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1519 8.9451 -0.4985 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4412 6.5135 0.6735 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8636 6.5707 -1.5943 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5520 3.5514 -0.7021 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7656 3.9392 -1.2257 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7199 1.4557 1.1351 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9996 1.1198 1.0144 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9157 0.0000 3.7849 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2216 1.8625 4.1719 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9217 2.0286 4.2554 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1488 5.5965 1.8249 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4203 3.6653 3.0583 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9952 2.0649 0.2617 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9445 4.0933 -0.8371 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5719 3.6787 0.7455 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 36 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 37 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 25 2 0 0 0 0 23 45 1 0 0 0 0 24 27 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 26 27 2 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 31 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 34 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 35 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 M END > (222) 220 > (222) C26H27Cl2N5O2 > (222) 512.4376 > (222) FGFR-P220 > (222) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 > (222) FGFR-1 Tyrosine Kinase > (222) 32 > (222) BINDDB > (222) <2007 > (222) P > (222) TRAIN $$$$ csChFnd70/04170815452D 65 68 0 0 0 0 0 0 0 0999 V2000 10.0699 12.4957 -0.7325 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1133 10.9279 0.1305 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1374 10.8286 -0.3495 N 0 0 0 0 0 0 0 0 0 0 0 0 11.6114 13.4632 -0.6878 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1676 12.6110 -0.2353 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6213 15.2532 -1.0857 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7498 15.2174 -0.5480 C 0 0 0 0 0 0 0 0 0 0 0 0 16.1230 15.9969 -0.4890 O 0 0 0 0 0 0 0 0 0 0 0 0 14.7022 13.5108 -0.1763 N 0 0 3 0 0 0 0 0 0 0 0 0 13.1589 16.1402 -1.0245 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2124 18.0172 -1.4349 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4848 18.5680 -3.1377 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5328 20.3195 -3.5116 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3116 21.5268 -2.2025 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0419 20.9894 -0.5118 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9835 19.2418 -0.1216 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6348 18.5701 1.9996 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.7633 17.0548 -4.7823 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.6269 10.0693 0.0710 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6243 8.3201 0.4603 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0542 7.4105 0.5429 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9814 5.6887 0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5705 8.2273 1.1569 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0226 7.3291 1.2379 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4325 4.7925 0.0995 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9494 5.6115 0.7061 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4246 4.7280 0.7868 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9494 5.6517 1.4244 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3664 4.4544 1.4201 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6268 3.0526 2.6845 N 0 0 0 0 0 0 0 0 0 0 0 0 0.9645 2.2657 3.1839 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2079 1.2004 4.8406 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8291 1.7377 2.0085 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1753 1.0840 0.2523 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3053 12.6061 0.2964 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1682 11.8897 -1.3411 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8548 13.1014 -1.0784 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4341 15.9110 -1.4331 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7438 20.7475 -4.8288 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3502 22.8949 -2.5016 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8710 21.9387 0.5045 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7100 7.7220 0.6765 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1358 5.0510 -0.4551 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6275 9.5643 1.5714 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8675 7.9659 1.7104 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3744 3.4552 -0.3143 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2034 6.0924 2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6977 6.7687 0.5947 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2139 5.1956 1.7686 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1982 3.9002 0.1301 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0112 3.2844 3.4143 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5109 1.4225 2.1434 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5360 5.1556 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2324 0.2463 4.6414 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5647 2.0596 5.9054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1127 2.3093 1.8505 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9033 0.6559 2.9162 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8330 0.6573 0.3780 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2505 2.1289 -0.6974 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9764 0.0000 -0.1751 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1852 13.5094 0.9361 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0034 11.5402 1.1751 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3610 11.2165 -0.9893 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2883 10.9863 -1.9807 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4701 12.9556 -2.2197 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 37 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 38 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 35 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 24 26 2 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 33 1 0 0 0 0 30 31 1 0 0 0 0 31 32 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 34 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 36 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 36 63 1 0 0 0 0 36 64 1 0 0 0 0 36 65 1 0 0 0 0 M END > (223) 221 > (223) C27H29Cl2N5O2 > (223) 526.4644 > (223) FGFR-P221 > (223) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 64 > (223) FGFR-1 Tyrosine Kinase > (223) 30 > (223) BINDDB > (223) <2007 > (223) P > (223) TRAIN $$$$ csChFnd70/04170815452D 63 67 0 0 0 0 0 0 0 0999 V2000 12.4588 8.2120 -3.5295 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0191 6.7686 -1.6063 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1444 6.9332 -2.4498 N 0 0 0 0 0 0 0 0 0 0 0 0 14.1563 8.8265 -3.6746 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4540 8.0500 -2.6593 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5729 10.1927 -4.8093 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5630 9.9137 -3.8321 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0564 10.3988 -3.9080 O 0 0 0 0 0 0 0 0 0 0 0 0 17.1294 8.6137 -2.7628 N 0 0 3 0 0 0 0 0 0 0 0 0 16.2485 10.7460 -4.9051 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7269 12.1747 -6.0822 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2205 11.8225 -7.7778 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6643 13.1604 -8.8687 C 0 0 0 0 0 0 0 0 0 0 0 0 17.6202 14.8465 -8.2837 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1325 15.2044 -6.6041 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6785 13.8789 -5.5022 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0572 14.3315 -3.3977 Cl 0 0 0 0 0 0 0 0 0 0 0 0 17.2774 9.7075 -8.5144 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.3992 6.2329 -1.5138 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9989 4.8970 -0.4033 N 0 0 3 0 0 0 0 0 0 0 0 0 11.2781 4.3921 -0.1807 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8812 2.6718 0.1272 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9682 5.6124 -0.2604 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2715 5.1134 -0.0408 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1839 2.1748 0.3466 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8755 3.3936 0.2594 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2044 2.9033 0.4762 O 0 0 0 0 0 0 0 0 0 0 0 0 18.4599 7.7935 -1.6991 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9234 4.2258 0.3701 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1356 3.4339 0.6448 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3000 2.0132 2.7358 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5649 3.9436 3.6970 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6267 3.0663 5.4655 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8404 2.3390 5.8957 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2942 1.0782 4.4755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0369 2.6841 2.3832 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4325 8.7701 -4.2898 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5848 10.7909 -5.5893 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0471 12.8897 -10.1814 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9685 15.8880 -9.1419 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1016 16.5235 -6.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9097 4.3087 0.2222 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8997 1.7227 0.1947 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2763 6.9516 -0.4938 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2521 6.0616 -0.1080 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8745 0.8361 0.5805 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0245 6.7148 -2.4038 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4629 8.7323 -1.3966 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8824 7.3232 -0.5059 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1651 5.1934 1.3622 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9783 4.8310 -0.8986 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1544 4.4325 0.5085 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9165 2.4273 -0.3131 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9293 1.1143 1.7194 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3842 3.0804 2.7743 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6385 5.0018 3.7310 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8394 4.4467 3.3786 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5658 2.0193 5.4377 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9990 4.0064 6.4433 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8921 1.6643 7.1290 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9105 3.3917 5.9730 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5979 4.7462 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1965 0.0000 4.4322 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 37 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 38 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 28 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 24 26 2 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 27 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 36 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 36 1 0 0 0 0 31 35 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 32 36 1 0 0 0 0 32 33 1 0 0 0 0 32 56 1 0 0 0 0 32 57 1 0 0 0 0 33 34 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 34 35 1 0 0 0 0 34 60 1 0 0 0 0 34 61 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 M END > (226) 224 > (226) C27H27Cl2N5O2 > (226) 524.4486 > (226) FGFR-P224 > (226) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 67 > (226) FGFR-1 Tyrosine Kinase > (226) 39 > (226) BINDDB > (226) <2007 > (226) P > (226) TRAIN $$$$ csChFnd70/04170815452D 58 62 0 0 0 0 0 0 0 0999 V2000 8.9003 10.0923 -0.6079 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5493 8.5861 -0.2144 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9322 8.6158 -0.4131 N 0 0 0 0 0 0 0 0 0 0 0 0 10.2710 10.8869 -0.6095 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6246 10.0721 -0.4025 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3092 12.4691 -0.8135 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0581 12.3140 -0.5866 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2779 12.9488 -0.5777 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9882 10.8069 -0.3963 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6751 13.1927 -0.8066 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7530 14.8501 -1.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8836 15.4577 -2.4655 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9559 17.0037 -2.6547 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8990 17.9493 -1.4131 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7695 17.3543 0.0248 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6897 15.8104 0.2292 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5184 15.0662 2.0341 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.9559 14.2730 -4.0251 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.2287 7.8857 -0.2214 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1975 6.3395 -0.0221 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8130 5.5866 0.1065 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6535 4.1358 -0.4659 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6016 6.2884 0.8120 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2370 5.5461 0.9396 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2887 3.3936 -0.3392 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0758 4.0974 0.3619 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3822 9.9436 -0.1799 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5714 4.2908 1.2660 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0538 3.4655 1.3038 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3592 1.0649 1.3037 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8768 1.8901 1.2659 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6926 3.3452 0.4904 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2380 2.0104 2.0792 N 0 0 0 0 0 0 0 0 0 0 0 0 0.7860 1.2208 2.2141 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8420 10.6764 -0.7680 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2767 13.0976 -0.9727 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0574 17.4755 -3.7744 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9562 19.1574 -1.5672 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7261 18.0986 0.9895 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1346 5.7750 0.0288 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5969 3.5882 -1.0105 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7271 7.4149 1.2613 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2941 6.0933 1.4854 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1634 2.2670 -0.7886 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8137 9.5803 -1.2737 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2207 10.6514 0.3772 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1496 8.9569 0.5175 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4446 5.3557 0.6626 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9469 4.5125 2.4166 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2289 4.1508 1.9072 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6635 3.2710 0.1531 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9837 0.8431 0.1530 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4860 0.0000 1.9070 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2671 2.0847 2.4165 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7017 1.2049 0.6625 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3255 1.0144 1.0917 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9547 0.1477 2.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9146 2.8585 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 35 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 36 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 37 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 24 26 2 0 0 0 0 24 43 1 0 0 0 0 25 26 1 0 0 0 0 25 44 1 0 0 0 0 26 32 1 0 0 0 0 27 45 1 0 0 0 0 27 46 1 0 0 0 0 27 47 1 0 0 0 0 28 32 1 0 0 0 0 28 29 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 33 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 33 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 33 34 1 0 0 0 0 34 56 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 M END > (227) 225 > (227) C25H24Cl2N6O > (227) 495.4102 > (227) FGFR-P225 > (227) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 > (227) FGFR-1 Tyrosine Kinase > (227) 28 > (227) BINDDB > (227) <2007 > (227) P > (227) TRAIN $$$$ csChFnd70/04170815452D 61 65 0 0 0 0 0 0 0 0999 V2000 9.1148 9.6611 -2.8403 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8480 8.4943 -0.9781 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0073 8.2499 -1.8975 N 0 0 0 0 0 0 0 0 0 0 0 0 10.6808 10.5649 -2.8698 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0731 9.9255 -1.8899 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8750 12.0843 -3.8556 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8471 12.2220 -2.8113 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2337 12.9574 -2.7915 O 0 0 0 0 0 0 0 0 0 0 0 0 13.6258 10.7711 -1.8846 N 0 0 3 0 0 0 0 0 0 0 0 0 12.4289 12.9196 -3.8426 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6738 14.5147 -4.8627 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2490 14.4195 -6.5637 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4739 15.9114 -7.5077 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1302 17.4975 -6.7705 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5601 17.6010 -5.0848 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3229 16.1184 -4.1289 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5978 16.2505 -2.0168 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.6817 12.4302 -7.4910 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.3457 7.6858 -0.9907 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1630 6.2005 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 8.5529 5.4030 0.1039 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4419 3.6204 0.2234 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0610 6.3919 0.1211 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4725 5.6001 0.2500 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8492 2.8368 0.3521 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3660 3.8247 0.3620 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0574 10.0895 -0.8600 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6304 2.9652 0.5031 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6041 2.1367 3.3498 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0907 2.0810 5.2534 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1117 1.6471 4.4372 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6251 1.7029 2.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1545 2.8003 2.3279 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5613 0.9835 5.4593 N 0 0 0 0 0 0 0 0 0 0 0 0 2.0854 0.8187 7.2840 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0227 10.1076 -3.5780 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8135 12.5787 -4.6081 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9195 15.8395 -8.8241 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3082 18.6603 -7.5143 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2945 18.8434 -4.5167 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1520 5.7111 0.5615 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5995 2.8483 0.2153 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1433 7.7785 0.0341 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3118 6.3678 0.2585 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7616 1.4507 0.4392 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8097 9.1975 -1.6420 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8776 11.1491 -0.4385 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5502 9.4148 0.2626 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6680 3.7413 -0.1635 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6905 1.6898 -0.0822 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7158 2.9799 3.1889 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9305 0.8419 2.9144 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1507 1.5541 6.0093 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7980 3.3808 5.6981 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7853 2.9420 4.8726 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.8040 4.5983 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9176 0.4031 2.0891 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5651 2.2299 1.7778 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8019 2.0895 7.8107 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9497 0.0000 7.3996 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1511 0.2439 7.9959 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 36 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 37 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 24 26 2 0 0 0 0 24 44 1 0 0 0 0 25 26 1 0 0 0 0 25 45 1 0 0 0 0 26 28 1 0 0 0 0 27 46 1 0 0 0 0 27 47 1 0 0 0 0 27 48 1 0 0 0 0 28 33 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 34 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 34 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 34 35 1 0 0 0 0 35 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 M END > (228) 226 > (228) C26H26Cl2N6O > (228) 509.437 > (228) FGFR-P226 > (228) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 69 > (228) FGFR-1 Tyrosine Kinase > (228) 49 > (228) BINDDB > (228) <2007 > (228) P > (228) TRAIN $$$$ csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 6.1234 7.8449 -0.6118 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7768 6.3362 -0.2158 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1554 6.3658 -0.4157 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4965 8.6408 -0.6134 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8524 7.8248 -0.4051 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5348 10.2257 -0.8187 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2885 10.0701 -0.5928 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5106 10.7059 -0.5848 O 0 0 0 0 0 0 0 0 0 0 0 0 10.2184 8.5606 -0.3999 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9030 10.9506 -0.8118 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9812 12.6108 -1.0246 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1125 13.2185 -2.4751 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1843 14.7672 -2.6656 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1263 15.7153 -1.4224 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9967 15.1200 0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9172 13.5736 0.2241 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7458 12.8293 2.0328 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.1861 12.0307 -4.0365 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4540 5.6347 -0.2228 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4227 4.0852 -0.0222 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0381 3.3323 0.1064 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8780 1.8773 -0.4676 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8267 4.0342 0.8119 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4473 3.2779 0.9371 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5117 1.1282 -0.3436 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2968 1.8193 0.3509 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6147 7.6962 -0.1816 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1488 4.0203 1.6816 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2824 5.2893 2.1908 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8166 3.2901 1.7960 O 0 0 0 0 0 0 0 0 0 0 0 0 5.0632 8.4298 -0.7727 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5005 10.8553 -0.9789 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2863 15.2390 -3.7876 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1829 16.9254 -1.5776 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9524 15.8663 0.9842 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3614 3.5198 0.0295 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8245 1.3306 -1.0127 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9503 5.1623 1.2633 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3931 0.0000 -0.7962 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2311 1.2301 0.4456 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0469 7.3304 -1.2766 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4546 8.4059 0.3755 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3815 6.7089 0.5187 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.8217 2.2924 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 31 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 32 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 27 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 33 1 0 0 0 0 14 15 1 0 0 0 0 14 34 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 37 1 0 0 0 0 23 24 1 0 0 0 0 23 38 1 0 0 0 0 24 26 2 0 0 0 0 24 28 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 27 42 1 0 0 0 0 27 43 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 44 1 0 0 0 0 M END > (229) 227 > (229) C21H14Cl2N4O3 > (229) 441.2726 > (229) FGFR-P227 > (229) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 70 > (229) FGFR-1 Tyrosine Kinase > (229) 110 > (229) BINDDB > (229) <2007 > (229) P > (229) TRAIN $$$$ csChFnd70/04170815452D 47 50 0 0 0 0 0 0 0 0999 V2000 5.5824 9.0615 -0.6082 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2375 7.5510 -0.2145 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6143 7.5812 -0.4132 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9565 9.8577 -0.6096 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3133 9.0407 -0.4027 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9948 11.4439 -0.8137 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7507 11.2876 -0.5887 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9736 11.9238 -0.5802 O 0 0 0 0 0 0 0 0 0 0 0 0 9.6803 9.7770 -0.3975 N 0 0 3 0 0 0 0 0 0 0 0 0 8.3641 12.1691 -0.8068 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4425 13.8306 -1.0182 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5732 14.4401 -2.4692 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6452 15.9900 -2.6585 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5879 16.9374 -1.4137 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4589 16.3406 0.0277 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3794 14.7930 0.2322 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2086 14.0465 2.0415 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6459 13.2528 -4.0328 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.9137 6.8491 -0.2215 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8824 5.2984 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 5.4970 4.5452 0.1054 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3352 3.0906 -0.4684 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2811 5.2470 0.8126 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9143 4.4995 0.9376 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9652 2.3494 -0.3395 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0777 8.9114 -0.1811 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7553 3.0538 0.3599 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2622 2.2413 0.4990 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2276 1.3618 1.9597 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3047 1.3914 2.8013 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.5451 2.3255 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5215 9.6471 -0.7682 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9599 12.0742 -0.9729 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7468 16.4631 -3.7808 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6448 18.1486 -1.5679 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4152 17.0865 0.9950 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8217 4.7325 0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2796 2.5400 -1.0151 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4046 6.3759 1.2643 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9671 5.0463 1.4836 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8372 1.2204 -0.7899 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5094 8.5466 -1.2776 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9187 9.6209 0.3767 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8447 7.9225 0.5187 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3438 3.0650 0.4930 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1257 1.4665 -0.4511 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0306 0.0000 3.2740 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 32 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 33 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 34 1 0 0 0 0 14 15 1 0 0 0 0 14 35 1 0 0 0 0 15 16 2 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 39 1 0 0 0 0 24 27 2 0 0 0 0 24 40 1 0 0 0 0 25 27 1 0 0 0 0 25 41 1 0 0 0 0 26 42 1 0 0 0 0 26 43 1 0 0 0 0 26 44 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 45 1 0 0 0 0 28 46 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 47 1 0 0 0 0 M END > (230) 228 > (230) C22H16Cl2N4O3 > (230) 455.2994 > (230) FGFR-P228 > (230) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 71 > (230) FGFR-1 Tyrosine Kinase > (230) 61 > (230) BINDDB > (230) <2007 > (230) P > (230) TRAIN $$$$ csChFnd70/04170815452D 53 56 0 0 0 0 0 0 0 0999 V2000 8.0960 12.2337 -0.6902 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1092 10.5195 -0.2434 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1322 10.5538 -0.4689 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6554 13.1374 -0.6919 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1953 12.2102 -0.4570 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6989 14.9377 -0.9234 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8266 14.7603 -0.6681 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2145 15.4822 -0.6585 O 0 0 0 0 0 0 0 0 0 0 0 0 12.7467 13.0459 -0.4511 N 0 0 3 0 0 0 0 0 0 0 0 0 11.2529 15.7607 -0.9156 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3420 17.6463 -1.1555 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4903 18.3380 -2.8023 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5720 20.0970 -3.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5070 21.1723 -1.6045 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3606 20.4949 0.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2703 18.7385 0.2635 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0765 17.8914 2.3169 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.5728 16.9906 -4.5769 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.6069 9.7228 -0.2513 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5713 7.9630 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9991 7.1081 0.1196 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8155 5.4572 -0.5316 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6191 7.9047 0.9222 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0678 7.0563 1.0641 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2605 4.6161 -0.3853 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3326 12.0634 -0.2055 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8874 5.4155 0.4084 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1928 4.4935 0.5663 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1529 3.4800 2.2494 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4325 2.5439 2.4095 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6158 1.5793 5.0226 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3932 1.5455 4.0674 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.6188 4.4827 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8919 12.8984 -0.8718 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5244 15.6529 -1.1041 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6873 20.6340 -4.2909 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5715 22.5469 -1.7794 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3110 21.3414 1.1292 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6374 7.3206 0.0319 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8872 4.8324 -1.1521 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7593 9.1858 1.4350 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9929 7.6768 1.6837 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1153 3.3348 -0.8965 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8227 11.6494 -1.4500 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2871 12.8686 0.4276 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0682 10.9411 0.5886 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1506 5.4282 0.5595 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0379 3.6141 -0.5119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1952 2.5453 2.2560 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3078 4.3594 3.3274 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3903 3.4786 2.4028 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2776 1.6643 1.3313 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0348 0.0000 5.5589 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 34 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 35 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 26 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 36 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 21 22 1 0 0 0 0 21 23 2 0 0 0 0 22 25 2 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 24 27 2 0 0 0 0 24 42 1 0 0 0 0 25 27 1 0 0 0 0 25 43 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 32 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 32 2 0 0 0 0 32 33 1 0 0 0 0 33 53 1 0 0 0 0 M END > (231) 229 > (231) C24H20Cl2N4O3 > (231) 483.353 > (231) FGFR-P229 > (231) 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 72 > (231) FGFR-1 Tyrosine Kinase > (231) 110 > (231) BINDDB > (231) <2007 > (231) P > (231) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7u csChFnd70/04170815452D 59 63 0 0 0 0 0 0 0 0999 V2000 6.5087 11.1167 -0.5574 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0506 8.8819 -0.1082 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6985 9.7337 0.1744 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2018 12.0651 -0.2899 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7594 11.3544 0.0858 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3086 13.7127 -0.3902 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0023 14.5953 -0.1192 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5249 13.8214 0.2676 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3579 14.6009 0.5095 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3894 9.5870 -0.4591 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4512 12.2504 0.3564 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9663 11.4902 0.7440 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0822 16.3226 -0.2161 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8702 18.6885 -1.7154 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7938 17.0779 -1.6331 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4394 17.2019 1.1107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5120 18.8118 1.0124 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2310 19.5527 -0.3972 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3408 15.9953 -3.2888 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.7913 16.2742 2.8810 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0031 7.2628 -0.0228 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3836 6.3948 -0.1642 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7415 4.1357 -1.1201 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1161 6.0781 0.3779 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7548 6.9340 0.5175 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3801 4.9915 -0.9806 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1143 4.6781 -0.4441 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7835 1.2778 -0.2474 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3007 3.6577 -0.0469 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7982 4.5937 0.2128 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2809 2.2139 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4939 3.8104 -0.5851 N 0 0 0 0 0 0 0 0 0 0 0 0 13.0876 2.0612 0.5505 N 0 0 0 0 0 0 0 0 0 0 0 0 14.5359 1.1503 0.4025 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6179 11.6433 -0.8508 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6175 9.1465 0.4585 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4066 14.2663 -0.6763 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8757 11.3543 2.0076 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.2065 0.3233 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9184 10.3442 0.1890 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6473 19.2743 -2.8112 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7885 19.4936 2.0383 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2892 20.8119 -0.4678 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0134 6.7323 0.1349 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7399 3.0470 -1.7594 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1838 6.5001 0.9033 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7565 8.0228 1.1564 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3127 4.5695 -1.5060 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6397 0.1033 0.2254 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0296 1.2069 -1.4956 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5642 3.6139 -1.2928 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2631 4.2183 0.5720 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5519 4.6648 1.4609 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9420 5.7682 -0.2600 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3185 1.6532 -0.6066 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0174 2.2578 1.2582 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8308 1.0188 -0.8301 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4821 1.7564 1.0032 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3694 0.0000 0.9244 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 37 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 41 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 42 1 0 0 0 0 18 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 49 1 0 0 0 0 28 50 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 51 1 0 0 0 0 29 52 1 0 0 0 0 30 32 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 33 34 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 M END > (24) 22 > (24) C26H25Cl2N5O > (24) 494.4224 > (24) FGFR-P22 > (24) 1,6-naphthyridin-2(1H)-one deriv. 7u > (24) FGFR-1 Tyrosine Kinase > (24) 42 > (24) BINDDB > (24) <2007 > (24) P > (24) TRAIN $$$$ 43 csChFnd70/04170815452D 96100 0 0 0 0 0 0 0 0999 V2000 4.4464 13.8123 -0.8177 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1944 16.2969 0.6020 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3801 17.3700 -0.2326 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5937 16.6653 -1.3663 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3470 19.1650 0.0628 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8886 20.0852 0.1871 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8824 20.0635 0.2805 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2897 22.7201 0.4402 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8826 21.8530 0.4271 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3817 19.2282 0.1644 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8338 21.8005 0.3189 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2275 24.5213 0.5790 N 0 0 3 0 0 0 0 0 0 0 0 0 7.1260 25.5078 -0.8644 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2085 24.8328 -2.2893 O 0 0 0 0 0 0 0 0 0 0 0 0 6.9332 27.2418 -0.7274 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8396 28.1597 -2.2337 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1495 29.3903 -4.5427 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2410 28.4571 -3.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3419 28.8070 -2.9912 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2435 29.7395 -4.5219 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6494 30.0283 -5.2987 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0797 28.4938 -2.1444 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6058 27.7622 -2.1887 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2704 25.3119 2.2234 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8485 25.7615 2.9669 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8910 26.5400 4.5849 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7266 25.6517 3.1059 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7732 26.4318 4.7268 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3559 26.8726 5.4685 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4019 27.6380 7.0601 O 0 0 0 0 0 0 0 0 0 0 0 0 9.0754 28.0643 7.7427 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1768 25.2186 2.3766 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6471 25.6054 3.3556 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4790 12.0666 -1.1045 O 0 0 0 0 0 0 0 0 0 0 0 0 5.5574 11.0485 0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4266 9.1333 -0.5039 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6277 14.8883 -1.6590 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5812 8.0435 0.6927 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6638 3.2753 0.4768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7699 5.1591 1.1051 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7007 5.5258 0.5234 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5947 3.6419 -0.1048 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4554 6.2045 0.1965 N 0 0 0 0 0 0 0 0 0 0 0 0 6.8172 14.1980 -2.7687 O 0 0 0 0 0 0 0 0 0 0 0 0 7.9914 15.3806 -3.5882 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9090 2.5964 0.8038 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7834 0.7576 0.3074 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2268 14.5197 0.3107 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0651 13.4688 1.1285 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8489 14.2842 2.2704 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2468 16.8468 1.4790 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5113 17.5016 -2.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2443 19.7641 0.1804 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0927 19.3533 0.2604 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0880 22.5650 0.5243 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9053 29.6217 -5.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4126 30.2436 -5.1121 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5752 30.7571 -6.4957 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6344 27.2874 -2.6375 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9507 29.5703 -2.4421 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9108 28.3972 -0.7416 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0823 28.7258 -1.2923 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6500 27.4866 -3.1968 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9026 26.5715 -1.4812 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0455 25.5029 2.2815 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1214 26.8895 5.1621 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5780 26.6969 5.4130 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9266 28.6658 9.0163 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8496 26.8844 7.8651 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7263 28.9673 6.8669 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5039 25.1947 2.6271 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6913 24.9167 4.5923 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5791 26.9999 3.5939 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9015 11.4793 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1292 11.2060 1.3540 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0826 8.7027 -0.3837 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8546 8.9760 -1.8448 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9252 8.4742 0.5726 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1529 8.2010 2.0336 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9392 3.2239 -0.9115 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6123 2.4896 1.1764 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5295 5.2062 2.5002 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0589 5.6772 0.8297 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7523 6.3115 -0.1761 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4254 5.5772 1.9118 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3055 3.1239 0.1706 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8351 3.5949 -1.4999 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2579 16.3203 -4.3530 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7433 16.0607 -2.5992 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8685 14.6624 -4.4373 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7114 0.0000 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4716 0.2882 0.5630 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0737 0.6199 -1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 13.3014 2.8359 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5477 14.9553 3.3034 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0709 15.2178 1.5428 H 0 0 0 0 0 0 0 0 0 0 0 0 1 34 1 0 0 0 0 1 37 2 0 0 0 0 1 48 1 0 0 0 0 2 48 2 0 0 0 0 2 3 1 0 0 0 0 2 51 1 0 0 0 0 3 4 2 0 0 0 0 3 5 1 0 0 0 0 4 37 1 0 0 0 0 4 52 1 0 0 0 0 5 6 1 0 0 0 0 5 53 1 0 0 0 0 6 10 2 0 0 0 0 6 11 1 0 0 0 0 7 10 1 0 0 0 0 7 9 2 0 0 0 0 7 54 1 0 0 0 0 8 11 2 0 0 0 0 8 9 1 0 0 0 0 8 12 1 0 0 0 0 9 55 1 0 0 0 0 12 13 1 0 0 0 0 12 24 1 0 0 0 0 13 15 1 0 0 0 0 13 14 2 0 0 0 0 15 16 1 0 0 0 0 16 18 2 0 0 0 0 16 19 1 0 0 0 0 17 18 1 0 0 0 0 17 21 2 0 0 0 0 17 56 1 0 0 0 0 18 23 1 0 0 0 0 19 20 2 0 0 0 0 19 22 1 0 0 0 0 20 21 1 0 0 0 0 20 57 1 0 0 0 0 21 58 1 0 0 0 0 22 59 1 0 0 0 0 22 60 1 0 0 0 0 22 61 1 0 0 0 0 23 62 1 0 0 0 0 23 63 1 0 0 0 0 23 64 1 0 0 0 0 24 25 2 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 65 1 0 0 0 0 26 29 2 0 0 0 0 26 66 1 0 0 0 0 27 28 2 0 0 0 0 27 32 1 0 0 0 0 28 29 1 0 0 0 0 28 67 1 0 0 0 0 29 30 1 0 0 0 0 30 31 1 0 0 0 0 31 68 1 0 0 0 0 31 69 1 0 0 0 0 31 70 1 0 0 0 0 32 33 1 0 0 0 0 33 71 1 0 0 0 0 33 72 1 0 0 0 0 33 73 1 0 0 0 0 34 35 1 0 0 0 0 35 36 1 0 0 0 0 35 74 1 0 0 0 0 35 75 1 0 0 0 0 36 38 1 0 0 0 0 36 76 1 0 0 0 0 36 77 1 0 0 0 0 37 44 1 0 0 0 0 38 43 1 0 0 0 0 38 78 1 0 0 0 0 38 79 1 0 0 0 0 39 40 1 0 0 0 0 39 46 1 0 0 0 0 39 80 1 0 0 0 0 39 81 1 0 0 0 0 40 43 1 0 0 0 0 40 82 1 0 0 0 0 40 83 1 0 0 0 0 41 43 1 0 0 0 0 41 42 1 0 0 0 0 41 84 1 0 0 0 0 41 85 1 0 0 0 0 42 46 1 0 0 0 0 42 86 1 0 0 0 0 42 87 1 0 0 0 0 44 45 1 0 0 0 0 45 88 1 0 0 0 0 45 89 1 0 0 0 0 45 90 1 0 0 0 0 46 47 1 0 0 0 0 47 91 1 0 0 0 0 47 92 1 0 0 0 0 47 93 1 0 0 0 0 48 49 1 0 0 0 0 49 50 1 0 0 0 0 50 94 1 0 0 0 0 50 95 1 0 0 0 0 50 96 1 0 0 0 0 M END > (232) 230 > (232) C37H46N6O7 > (232) 686.8064 > (232) FGFR-P230 > (232) 2-aminopyrimidine carbamate, 43 > (232) FGFR-1 Tyrosine Kinase > (232) 110 > (232) BINDDB > (232) <2007 > (232) P > (232) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7v csChFnd70/04170815452D 55 59 0 0 0 0 0 0 0 0999 V2000 8.1742 10.5225 0.5478 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4604 8.2067 0.0785 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8624 8.9574 -0.1946 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5382 11.3721 0.2908 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9178 10.5680 -0.0902 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5500 13.0125 0.4070 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9087 13.7969 0.1461 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3186 12.9277 -0.2469 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5316 13.6197 -0.4799 O 0 0 0 0 0 0 0 0 0 0 0 0 8.1830 8.9981 0.4347 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2793 11.3656 -0.3509 N 0 0 3 0 0 0 0 0 0 0 0 0 13.6975 10.5093 -0.7442 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9530 15.5145 0.2596 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3321 17.8304 1.7737 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2925 16.2285 1.6757 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6621 16.4252 -1.0505 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7054 18.0258 -0.9368 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0365 18.7264 0.4719 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6636 15.1062 3.3108 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.2476 15.5482 -2.8197 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.3918 6.5987 -0.0227 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9606 5.8353 0.1097 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4521 3.6826 1.0380 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2284 5.7221 -0.4315 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6396 6.4748 -0.5622 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8634 4.4354 0.9074 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1299 4.3256 0.3718 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2300 1.1573 0.1195 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9097 3.6024 -0.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4621 4.4407 -0.2815 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7956 1.9708 -0.1105 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6996 3.5624 0.5038 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0362 2.0465 -0.6204 O 0 0 0 0 0 0 0 0 0 0 0 0 7.1117 11.1211 0.8451 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8924 8.3007 -0.4833 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5006 13.6371 0.6973 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7781 10.3808 -2.0018 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7068 11.1464 -0.3193 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6629 9.3641 -0.2040 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5946 18.3846 2.8688 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4803 18.7320 -1.9498 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0688 19.9784 0.5546 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3354 6.0034 -0.1851 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3756 2.5967 1.6627 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2002 6.2222 -0.9492 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7162 7.5610 -1.1864 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8916 3.9353 1.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2751 0.0000 -0.3936 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9806 1.0624 1.3579 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6219 3.5786 1.1837 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.2135 -0.6853 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7195 4.5197 -1.5194 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3916 5.6055 0.2119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6989 1.3326 0.5075 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0745 2.0103 -1.3456 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 34 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 35 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 36 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 37 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 40 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 41 1 0 0 0 0 18 42 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 32 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (25) 23 > (25) C25H22Cl2N4O2 > (25) 481.3804 > (25) FGFR-P23 > (25) 1,6-naphthyridin-2(1H)-one deriv. 7v > (25) FGFR-1 Tyrosine Kinase > (25) 8700 > (25) BINDDB > (25) <2007 > (25) P > (25) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7w csChFnd70/04170815452D 58 61 0 0 0 0 0 0 0 0999 V2000 6.3203 11.4485 3.2792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4303 9.7257 2.1854 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1767 10.7787 2.5047 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1300 12.5798 3.6449 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5164 12.2354 3.2469 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5216 14.0511 4.4021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3206 15.1223 4.7384 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6596 14.7277 4.3097 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5851 15.6768 4.6059 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9358 10.0865 2.5753 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3155 13.3192 3.5890 N 0 0 3 0 0 0 0 0 0 0 0 0 0.6495 12.9386 3.1663 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6974 16.6711 5.5311 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4139 19.4626 5.3548 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0641 18.0223 4.6082 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6804 16.7868 7.2039 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0324 18.2345 7.9354 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4006 19.5679 7.0137 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0815 17.8928 2.5262 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.2172 15.1154 8.3627 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.1045 8.2671 1.4442 N 0 0 3 0 0 0 0 0 0 0 0 0 5.3610 7.2650 0.9817 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0574 6.9380 0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4013 4.6106 0.5609 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1611 5.6046 1.0175 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8130 7.9254 0.4776 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8625 5.2701 0.0592 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1941 4.2078 -0.4322 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0345 4.5693 -1.5715 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4792 2.8369 0.3816 N 0 0 0 0 0 0 0 0 0 0 0 0 10.7583 1.7490 -0.1472 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3340 2.2068 0.6819 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5100 2.4347 1.7951 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2862 1.1369 1.3500 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5600 11.6973 3.5713 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9582 10.4712 2.1812 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7521 14.3245 4.7112 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0761 12.3179 4.1671 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.0469 2.9102 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6329 12.1681 2.1073 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6980 20.5092 4.6420 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0197 18.3257 9.2298 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6744 20.6970 7.5916 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0011 7.9462 1.2486 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1848 7.4509 -0.3689 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2470 3.3225 0.5936 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0316 5.0961 1.4045 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9628 9.2142 0.4465 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4414 0.5175 0.1668 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9040 1.8449 -1.4453 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2855 1.3974 0.2884 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6508 3.4383 0.3679 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1882 2.1109 1.9800 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2911 1.9900 2.7479 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8797 3.5048 2.2111 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4206 1.0008 2.3235 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6594 1.4853 0.2540 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9068 0.0000 1.1555 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 37 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 38 1 0 0 0 0 12 39 1 0 0 0 0 12 40 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 41 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 42 1 0 0 0 0 18 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 47 1 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 28 29 2 0 0 0 0 28 30 1 0 0 0 0 30 31 1 0 0 0 0 30 33 1 0 0 0 0 31 32 1 0 0 0 0 31 49 1 0 0 0 0 31 50 1 0 0 0 0 32 51 1 0 0 0 0 32 52 1 0 0 0 0 32 53 1 0 0 0 0 33 34 1 0 0 0 0 33 54 1 0 0 0 0 33 55 1 0 0 0 0 34 56 1 0 0 0 0 34 57 1 0 0 0 0 34 58 1 0 0 0 0 M END > (26) 24 > (26) C26H24Cl2N4O2 > (26) 495.4072 > (26) FGFR-P24 > (26) 1,6-naphthyridin-2(1H)-one deriv. 7w > (26) FGFR-1 Tyrosine Kinase > (26) 1900 > (26) BINDDB > (26) <2007 > (26) P > (26) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8f csChFnd70/04170815452D 55 57 0 0 0 0 0 0 0 0999 V2000 1.0273 15.8307 0.6606 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8341 12.9043 0.4885 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6096 13.3139 0.4193 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7873 16.3602 0.5975 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1125 15.0677 0.4737 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2495 18.1598 0.6547 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9859 18.6192 0.5884 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3272 17.2458 0.4601 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8752 17.6467 0.4020 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6201 14.1525 0.6049 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8556 15.5405 0.4084 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5058 20.4935 0.6452 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3148 23.0582 2.2977 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8307 21.3103 2.2538 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6802 21.4481 -0.9099 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1653 23.1952 -0.8477 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4786 23.9987 0.7516 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6258 20.1322 4.1954 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2889 20.4417 -2.9184 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1.3175 11.1578 0.4347 N 0 0 3 0 0 0 0 0 0 0 0 0 2.6408 9.7665 0.3063 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7288 7.9758 0.2698 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1108 6.5229 0.1360 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1989 4.7323 0.0994 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5258 3.3371 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7314 1.6001 0.2445 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3584 1.3347 2.2014 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4504 3.4161 -1.7210 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1337 2.3231 -1.6160 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.8039 0.7612 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 12.2868 0.3252 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2452 19.1571 0.7489 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7522 14.6392 0.3238 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5662 23.6920 3.5417 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3006 23.9354 -2.0502 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8576 25.3652 0.7931 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0801 10.8577 0.4818 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4006 9.9396 -0.8948 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5152 9.8337 1.4381 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9690 7.8027 1.4709 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8543 7.9085 -0.8618 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8706 6.6960 -1.0652 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9853 6.5900 1.2677 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4390 4.5592 1.3006 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3245 4.6650 -1.0323 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5059 1.5144 -0.4909 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6333 0.5857 -0.2112 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8891 0.0000 2.4212 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5606 1.5473 2.9496 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3597 2.2680 2.6277 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6052 2.8930 -2.7515 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7823 4.7762 -2.0205 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8099 2.3659 -2.8774 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9872 2.8579 -0.5985 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8032 0.9669 -1.2974 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 33 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 34 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 20 21 1 0 0 0 0 20 37 1 0 0 0 0 21 22 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 25 28 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 M END > (27) 25 > (27) C22H26Cl2N4O > (27) 433.3796 > (27) FGFR-P25 > (27) 1,6-naphthyridin-2(1H)-one deriv. 8f > (27) FGFR-1 Tyrosine Kinase > (27) 170 > (27) BINDDB > (27) <2007 > (27) P > (27) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8h csChFnd70/04170815452D 55 58 0 0 0 0 0 0 0 0999 V2000 1.2235 16.2413 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7164 13.6383 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 14.4635 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7785 17.1775 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3654 16.2641 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7782 19.0121 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3278 19.8754 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9500 18.8888 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3336 19.6502 -0.0303 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2467 14.5361 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9182 17.1421 -0.0285 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3643 21.7958 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4310 24.4875 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3970 22.6974 1.5755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3738 22.7107 -1.5534 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4079 24.5009 -1.5370 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4333 25.3869 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3940 21.5711 3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3436 21.6012 -3.5114 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6515 11.8411 -0.0259 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2610 10.8328 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8285 8.8969 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5094 7.8441 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7559 5.5800 1.2119 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2872 3.6556 1.0932 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1889 3.0110 0.0874 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6575 4.9353 0.2061 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0941 5.9853 -0.0822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8506 2.6058 1.3814 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 0.7470 1.3748 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9218 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5009 13.7185 -0.0420 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5711 19.7213 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9985 16.4987 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4557 25.1870 2.7865 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4153 25.2106 -2.7438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4599 26.7868 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5406 11.2518 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0030 11.1540 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0246 11.1407 1.1017 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0865 8.5759 1.1054 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0650 8.5890 -1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2513 8.1651 -1.2345 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2730 8.1520 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6056 6.3618 0.9613 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2484 5.8663 2.5052 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3220 3.3440 2.0771 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7616 3.3767 -0.1886 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6963 2.7247 -1.2058 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3391 2.2293 0.3379 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1831 5.2143 1.4878 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6229 5.2471 -0.7778 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8763 0.3937 0.1259 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6153 0.0000 1.5908 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5066 0.4682 2.4025 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 34 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 35 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 36 1 0 0 0 0 17 37 1 0 0 0 0 20 21 1 0 0 0 0 20 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 28 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 29 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 29 30 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 M END > (28) 26 > (28) C22H25Cl2N5O > (28) 446.3784 > (28) FGFR-P26 > (28) 1,6-naphthyridin-2(1H)-one deriv. 8h > (28) FGFR-1 Tyrosine Kinase > (28) 72 > (28) BINDDB > (28) <2007 > (28) P > (28) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 8r csChFnd70/04170815452D 63 66 0 0 0 0 0 0 0 0999 V2000 10.6024 10.1095 1.1053 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0892 12.1492 -0.4593 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5959 13.0127 -0.9027 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0362 10.9003 0.7199 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0337 12.3907 -0.3110 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4696 10.2289 1.3452 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9683 11.0421 0.9370 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0109 12.5850 -0.1350 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6786 13.3140 -0.5031 O 0 0 0 0 0 0 0 0 0 0 0 0 12.0470 10.7498 0.5133 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5183 13.2008 -0.7158 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3104 10.3658 1.5744 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1093 10.2880 3.7314 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6560 10.9233 3.1448 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3924 9.1742 0.6034 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8471 8.5493 1.2047 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2092 9.1020 2.7658 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7842 12.4111 4.3590 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.1907 8.4794 -1.3564 Cl 0 0 0 0 0 0 0 0 0 0 0 0 13.6564 12.7594 -1.0431 N 0 0 3 0 0 0 0 0 0 0 0 0 15.1537 11.8110 -0.7532 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1598 11.7124 -0.1037 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1153 9.9348 -0.1796 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5896 9.0970 -0.5500 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1119 10.0316 -0.8363 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6834 12.6490 -0.3895 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5698 9.0136 0.1021 O 0 0 0 0 0 0 0 0 0 0 0 0 19.4308 7.1880 0.0038 C 0 0 0 0 0 0 0 0 0 0 0 0 21.1843 6.3786 0.3547 C 0 0 0 0 0 0 0 0 0 0 0 0 21.0357 4.4242 0.2494 C 0 0 0 0 0 0 0 0 0 0 0 0 22.7192 3.6469 0.5863 N 0 0 0 0 0 0 0 0 0 0 0 0 22.5711 1.7800 0.7974 C 0 0 0 0 0 0 0 0 0 0 0 0 21.7826 1.3801 2.5499 C 0 0 0 0 0 0 0 0 0 0 0 0 23.9469 4.0773 -0.7774 C 0 0 0 0 0 0 0 0 0 0 0 0 25.7721 3.7156 -0.1527 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6248 8.9724 1.8968 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6478 14.1494 -1.6933 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4591 9.0898 2.1338 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5352 14.2233 -1.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6015 10.7185 4.9467 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1353 7.6273 0.4543 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.6097 3.2300 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7146 13.8430 -1.6520 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3482 12.3638 0.1854 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5560 7.7130 -0.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9239 9.3790 -1.1243 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7184 14.0329 -0.3307 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5109 6.7386 0.9563 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9957 6.8219 -1.2738 H 0 0 0 0 0 0 0 0 0 0 0 0 22.1043 6.8280 -0.5979 H 0 0 0 0 0 0 0 0 0 0 0 0 21.6197 6.7449 1.6322 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1157 3.9748 1.2020 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6004 4.0579 -1.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 21.7536 1.2603 -0.2112 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8407 1.1993 0.7140 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5119 2.0326 3.5489 H 0 0 0 0 0 0 0 0 0 0 0 0 20.4565 1.8228 2.5763 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8179 0.0000 2.7730 H 0 0 0 0 0 0 0 0 0 0 0 0 23.6786 3.2998 -1.9085 H 0 0 0 0 0 0 0 0 0 0 0 0 23.8256 5.4317 -1.1034 H 0 0 0 0 0 0 0 0 0 0 0 0 25.9923 4.3839 1.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 25.9352 2.3398 0.0390 H 0 0 0 0 0 0 0 0 0 0 0 0 26.6894 4.1650 -1.1077 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 38 1 0 0 0 0 7 8 1 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 39 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 40 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 42 1 0 0 0 0 20 21 1 0 0 0 0 20 43 1 0 0 0 0 21 25 2 0 0 0 0 21 26 1 0 0 0 0 22 23 1 0 0 0 0 22 26 2 0 0 0 0 22 44 1 0 0 0 0 23 24 2 0 0 0 0 23 27 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 48 1 0 0 0 0 28 49 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 35 1 0 0 0 0 34 59 1 0 0 0 0 34 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 35 63 1 0 0 0 0 M END > (29) 27 > (29) C27H28Cl2N4O2 > (29) 511.4498 > (29) FGFR-P27 > (29) 1,6-naphthyridin-2(1H)-one deriv. 8r > (29) FGFR-1 Tyrosine Kinase > (29) 440 > (29) BINDDB > (29) <2007 > (29) P > (29) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7a csChFnd70/04170815452D 32 34 0 0 0 0 0 0 0 0999 V2000 1.0846 4.4928 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4080 2.1851 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8257 2.9166 -0.0239 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4631 5.3227 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8701 4.5130 -0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4629 6.9491 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8366 7.7144 0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2749 6.8398 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5014 7.5148 -0.0259 O 0 0 0 0 0 0 0 0 0 0 0 0 2.3506 0.5918 -0.0218 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1052 2.9810 0.0023 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2466 5.2913 -0.0253 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6931 4.4298 -0.0431 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8691 9.4169 0.0082 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9278 11.8027 1.3977 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8977 10.2156 1.3986 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8779 10.2285 -1.3750 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9082 11.8155 -1.3599 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9297 12.6005 0.0224 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8947 9.2167 3.1258 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.8516 9.2454 -3.1112 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0960 0.0294 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8767 2.2562 -0.0375 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3927 7.5777 0.0232 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3657 0.0694 -0.0149 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2953 0.0000 -0.0340 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0405 4.2215 -1.2285 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5808 5.0920 0.5421 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5339 3.3345 0.5440 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9496 12.4223 2.4730 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9154 12.4450 -2.4296 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9534 13.8415 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 4 2 0 0 0 0 1 22 1 0 0 0 0 2 11 2 0 0 0 0 2 3 1 0 0 0 0 2 10 1 0 0 0 0 3 5 2 0 0 0 0 3 23 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 12 1 0 0 0 0 6 7 2 0 0 0 0 6 24 1 0 0 0 0 7 8 1 0 0 0 0 7 14 1 0 0 0 0 8 12 1 0 0 0 0 8 9 2 0 0 0 0 10 25 1 0 0 0 0 10 26 1 0 0 0 0 12 13 1 0 0 0 0 13 27 1 0 0 0 0 13 28 1 0 0 0 0 13 29 1 0 0 0 0 14 16 1 0 0 0 0 14 17 2 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 15 30 1 0 0 0 0 16 20 1 0 0 0 0 17 18 1 0 0 0 0 17 21 1 0 0 0 0 18 19 2 0 0 0 0 18 31 1 0 0 0 0 19 32 1 0 0 0 0 M END > (4) 2 > (4) C15H11Cl2N3O > (4) 320.1774 > (4) FGFR-P2 > (4) 1,6-naphthyridin-2(1H)-one deriv. 7a > (4) FGFR-1 Tyrosine Kinase > (4) 380 > (4) BINDDB > (4) <2007 > (4) P > (4) TRAIN $$$$ Structure4 csChFnd70/04170815452D 27 29 0 0 0 0 0 0 0 0999 V2000 2.3215 4.1088 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3417 2.6242 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6418 1.8838 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9335 2.6285 -0.0221 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6052 4.8729 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9251 4.1359 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4093 6.4263 -0.0083 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9456 6.3235 0.0057 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9804 5.1481 -0.0187 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9680 7.4718 0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1252 8.5762 1.0149 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1597 9.7068 1.0266 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0376 9.7395 0.0494 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8779 8.6407 -0.9420 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8436 7.5106 -0.9636 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6458 0.4189 -0.0207 O 0 0 0 0 0 0 0 0 0 0 0 0 6.2030 1.8998 -0.0371 O 0 0 0 0 0 0 0 0 0 0 0 0 1.3070 4.6765 0.0182 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3406 2.0332 0.0085 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0073 7.4232 -0.0089 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0012 8.5512 1.7787 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2813 10.5660 1.8002 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2841 10.6246 0.0607 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 8.6688 -1.7035 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7214 6.6556 -1.7416 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6378 0.0000 -0.9735 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5615 1.6935 -0.9923 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 18 1 0 0 0 0 2 3 2 0 0 0 0 2 19 1 0 0 0 0 3 4 1 0 0 0 0 3 16 1 0 0 0 0 4 6 2 0 0 0 0 4 17 1 0 0 0 0 5 8 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 20 1 0 0 0 0 8 10 1 0 0 0 0 10 11 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 21 1 0 0 0 0 12 13 2 0 0 0 0 12 22 1 0 0 0 0 13 14 1 0 0 0 0 13 23 1 0 0 0 0 14 15 2 0 0 0 0 14 24 1 0 0 0 0 15 25 1 0 0 0 0 16 26 1 0 0 0 0 17 27 1 0 0 0 0 M END > (301) 300 > (301) C13H10N2O2 > (301) 226.2342 > (301) FGFR-P300 > (301) 5-Substituted 1-Phenylbenzimidazole 27 > (301) FGFR-1 Tyrosine Kinase > (301) 1900 > (301) BINDDB > (301) <2007 > (301) P > (301) TRAIN $$$$ 1,6-naphthyridine 17 csChFnd70/04170815452D 80 83 0 0 0 0 0 0 0 0999 V2000 2.7517 18.9683 0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8871 18.8736 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3267 19.8338 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3987 16.2668 -0.0175 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7765 17.1434 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2428 16.1644 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8080 13.5952 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3860 14.4452 -0.0279 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3139 14.4615 0.0010 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8814 17.1652 -0.0269 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3739 21.7577 0.0116 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4605 24.4305 1.2049 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4635 25.3591 0.0280 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4188 22.6329 1.2001 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3793 22.6944 -1.1734 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4271 24.4918 -1.1616 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4569 25.4064 -2.3164 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5684 27.2557 -2.2315 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4792 25.2850 2.3638 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4595 27.1382 2.2961 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7796 11.7914 -0.0279 N 0 0 3 0 0 0 0 0 0 0 0 0 4.4110 10.8150 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0176 8.8687 -0.0562 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7214 7.8491 -0.0780 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0123 5.5472 1.2101 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5823 3.6115 1.0908 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4998 3.0255 0.0841 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9298 4.9612 0.2035 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3437 5.9803 -0.0851 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1685 2.5924 1.3793 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7908 0.7237 1.3722 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4615 19.7500 -0.0287 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9624 18.8518 -0.0484 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9376 17.2741 -0.0567 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4907 19.7025 -0.0591 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1932 17.5918 -1.7087 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6516 19.9927 -0.0889 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1221 18.7261 -0.0805 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2254 17.5743 1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5405 19.6736 0.0337 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.8123 0.0273 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5869 13.7224 -0.0427 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4979 26.7603 0.0348 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1950 21.9106 2.1170 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5726 22.0200 -2.1002 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9059 27.6582 -2.4556 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7326 27.8244 -3.2211 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1517 27.6950 -0.9530 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1445 27.6046 2.5296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3262 27.6555 3.2872 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8927 27.5682 1.0198 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6797 11.1791 -0.0211 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1473 11.1517 -1.2089 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1690 11.1385 1.1011 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2813 8.5320 1.1039 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2597 8.5452 -1.2061 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4576 8.1857 -1.2380 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4793 8.1725 1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8451 6.3062 0.9594 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4993 5.8435 2.5048 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6224 3.2796 2.0756 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0621 3.3218 -0.1923 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0129 2.7292 -1.2105 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6670 2.2666 0.3350 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4500 5.2509 1.4867 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8897 5.2931 -0.7813 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2385 0.3590 0.1220 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9869 0.0000 1.5886 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8665 0.4256 2.4010 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4814 21.0086 -0.0222 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5106 20.9613 -0.0526 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1196 18.4123 -2.8588 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4070 16.8654 -1.7247 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1037 16.6894 -1.7028 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6008 20.8009 1.0711 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8653 19.2663 -0.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5778 20.8133 -1.2389 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1359 16.6720 1.5396 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4394 16.8479 1.5177 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1748 18.3825 2.6937 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 40 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 32 1 0 0 0 0 3 11 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 41 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 42 1 0 0 0 0 11 15 1 0 0 0 0 11 14 2 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 19 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 44 1 0 0 0 0 15 16 2 0 0 0 0 15 45 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 19 20 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 21 22 1 0 0 0 0 21 52 1 0 0 0 0 22 23 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 24 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 29 1 0 0 0 0 24 57 1 0 0 0 0 24 58 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 59 1 0 0 0 0 25 60 1 0 0 0 0 26 30 1 0 0 0 0 26 61 1 0 0 0 0 26 62 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 63 1 0 0 0 0 27 64 1 0 0 0 0 28 29 1 0 0 0 0 28 65 1 0 0 0 0 28 66 1 0 0 0 0 30 31 1 0 0 0 0 31 67 1 0 0 0 0 31 68 1 0 0 0 0 31 69 1 0 0 0 0 32 33 1 0 0 0 0 32 70 1 0 0 0 0 33 34 2 0 0 0 0 33 35 1 0 0 0 0 35 38 1 0 0 0 0 35 71 1 0 0 0 0 36 38 1 0 0 0 0 36 72 1 0 0 0 0 36 73 1 0 0 0 0 36 74 1 0 0 0 0 37 38 1 0 0 0 0 37 75 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 38 39 1 0 0 0 0 39 78 1 0 0 0 0 39 79 1 0 0 0 0 39 80 1 0 0 0 0 M END > (32) 30 > (32) C29H41N7O3 > (32) 535.688 > (32) FGFR-P30 > (32) 1,6-naphthyridine 17 > (32) FGFR-1 Tyrosine Kinase > (32) 24 > (32) BINDDB > (32) <2007 > (32) P > (32) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 11 csChFnd70/04170815452D 29 31 0 0 0 0 0 0 0 0999 V2000 0.9935 4.1320 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2290 2.0123 -0.0134 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2947 4.8616 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5724 4.0607 -0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3628 6.3525 0.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9179 6.1181 -0.0160 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 6.9824 0.0003 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0125 2.7321 0.0021 N 0 0 0 0 0 0 0 0 0 0 0 0 3.4813 2.6418 -0.0219 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8265 4.7210 -0.0232 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8269 8.5513 0.0075 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0286 10.7473 1.2915 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9024 9.2855 1.2921 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8850 9.2987 -1.2704 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0112 10.7603 -1.2565 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0805 11.4827 0.0208 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8373 8.3645 2.8879 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7995 8.3939 -2.8745 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.1785 0.5454 -0.0207 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2427 6.7510 -0.0249 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.7051 0.0271 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4076 6.9876 0.0213 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0867 11.3171 2.2854 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0564 11.3403 -2.2452 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1792 12.6254 0.0260 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2692 0.0612 -0.0147 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0525 0.0000 -0.0320 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0920 6.1680 -0.0361 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3229 7.7781 -0.0197 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 21 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 19 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 22 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 20 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 23 1 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 24 1 0 0 0 0 16 25 1 0 0 0 0 19 26 1 0 0 0 0 19 27 1 0 0 0 0 20 28 1 0 0 0 0 20 29 1 0 0 0 0 M END > (322) 321 > (322) C13H9Cl2N5 > (322) 306.1536 > (322) FGFR-P321 > (322) 6-arylpyrido[2,3-d]pyrimidine deriv. 11 > (322) FGFR-1 Tyrosine Kinase > (322) 3000 > (322) BINDDB > (322) <2007 > (322) P > (322) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 12 csChFnd70/04170815452D 52 54 0 0 0 0 0 0 0 0999 V2000 7.6489 12.8317 -0.3246 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4502 9.8947 -0.2686 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4428 13.2886 -0.3485 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7178 11.9187 -0.3294 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0024 15.0538 -0.3898 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9906 13.9529 -0.3894 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7981 15.3825 -0.4102 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2227 11.1478 -0.2856 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1536 10.2474 -0.2896 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4332 12.3079 -0.3506 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4629 17.2195 -0.4543 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4088 19.8325 1.0644 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7889 18.1213 1.1144 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7723 18.0508 -2.0649 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3923 19.7623 -2.0971 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7070 20.6515 -0.5369 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4156 17.0955 3.1255 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.3795 16.9365 -4.0246 Cl 0 0 0 0 0 0 0 0 0 0 0 0 14.7817 14.2865 -0.4105 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9194 8.1526 -0.2275 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0384 7.7167 -0.2035 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8131 5.7131 -0.1592 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8487 5.2578 -0.1342 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6325 3.3341 -0.0917 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2972 2.5976 1.5712 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5421 0.6055 1.3737 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7834 2.8372 -0.3805 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3297 3.0420 -2.3350 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6414 13.8376 -0.3323 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0610 16.1214 -0.4054 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6614 20.5322 2.2780 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6324 20.4076 -3.3433 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1917 21.9898 -0.5692 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6130 13.3152 -0.3969 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2073 15.4918 -0.4389 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7924 7.2184 -0.2146 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4280 8.2931 0.9625 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4097 8.2434 -1.3832 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4234 5.1366 -1.3252 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4418 5.1864 1.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2384 5.8342 1.0318 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2199 5.7844 -1.3137 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5583 3.2056 1.8938 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3549 2.8625 2.6230 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0169 0.0563 2.6136 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2849 0.0000 1.0321 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4990 0.3413 0.3352 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5874 1.4701 0.0158 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9307 3.6894 0.4010 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5523 -2.5717 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4011 4.4297 -2.7001 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2647 2.2899 -3.1250 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 29 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 30 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 19 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 31 1 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 32 1 0 0 0 0 16 33 1 0 0 0 0 19 34 1 0 0 0 0 19 35 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 28 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 M END > (323) 322 > (323) C20H24Cl2N6 > (323) 419.3558 > (323) FGFR-P322 > (323) 6-arylpyrido[2,3-d]pyrimidine deriv. 12 > (323) FGFR-1 Tyrosine Kinase > (323) 2400 > (323) BINDDB > (323) <2007 > (323) P > (323) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 13 csChFnd70/04170815452D 68 70 0 0 0 0 0 0 0 0999 V2000 7.5248 12.6218 -0.3193 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3132 9.7327 -0.2642 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2901 13.0711 -0.3428 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5441 11.7234 -0.3240 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8410 14.8066 -0.3833 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7798 13.7232 -0.3829 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6083 15.1289 -0.4035 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1056 10.9656 -0.2810 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9888 10.0794 -0.2849 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2314 12.1060 -0.3449 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2636 16.9358 -0.4469 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1950 19.5057 1.0470 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5849 17.8225 1.0962 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5683 17.7533 -2.0312 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1786 19.4368 -2.0629 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4881 20.3116 -0.5282 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2178 16.8134 3.0744 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.1820 16.6572 -3.9589 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.7909 8.0191 -0.2238 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9405 7.5906 -0.2002 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7188 5.6196 -0.1566 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7863 5.1719 -0.1320 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5733 3.2797 -0.0901 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2271 2.5551 1.5456 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4678 0.5955 1.3515 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7544 2.7909 -0.3743 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3082 2.9925 -2.2968 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5484 14.0519 -0.4032 N 0 0 3 0 0 0 0 0 0 0 0 0 15.6840 12.7239 -0.3840 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1588 11.2380 -0.3489 O 0 0 0 0 0 0 0 0 0 0 0 0 17.4021 13.0431 -0.4037 N 0 0 3 0 0 0 0 0 0 0 0 0 18.3435 10.4556 -1.9768 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4878 12.3121 -0.4118 C 0 0 0 0 0 0 0 0 0 0 0 0 18.6366 11.5996 -0.3829 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3680 10.5234 1.2619 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5338 13.6112 -0.3269 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9154 15.8575 -0.3988 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4442 20.1939 2.2409 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4151 20.0714 -3.2888 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9654 21.6277 -0.5599 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6495 7.1001 -0.2111 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3402 8.1576 0.9467 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3219 8.1087 -1.3607 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3191 5.0525 -1.3037 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3371 5.1014 1.0037 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1859 5.7391 1.0149 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1678 5.6901 -1.2924 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4679 3.1530 1.8630 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3001 2.8157 2.5801 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2311 0.0000 1.0152 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4092 0.3354 0.3297 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9348 0.0552 2.5709 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5614 1.4463 0.0156 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9156 3.6294 0.3944 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5110 -2.5298 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3786 4.3575 -2.6561 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2278 2.2527 -3.0740 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9674 15.2373 -0.4312 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8211 14.2286 -0.4318 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5348 11.2221 -3.1486 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2619 9.3814 -1.9614 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0245 9.9478 -1.9562 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6967 13.1271 0.7237 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4063 11.2380 -0.3962 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6792 13.0787 -1.5836 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0491 10.0158 1.2825 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2865 9.4494 1.2775 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5768 11.3384 2.3974 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 36 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 19 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 37 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 28 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 40 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 34 1 0 0 0 0 31 59 1 0 0 0 0 32 34 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (324) 323 > (324) C25H33Cl2N7O > (324) 518.488 > (324) FGFR-P323 > (324) 6-arylpyrido[2,3-d]pyrimidine deriv. 13 > (324) FGFR-1 Tyrosine Kinase > (324) 82 > (324) BINDDB > (324) <2007 > (324) P > (324) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 17 csChFnd70/04170815452D 74 76 0 0 0 0 0 0 0 0999 V2000 7.4165 12.6550 0.6019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2380 9.7681 0.4205 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0129 10.9906 0.5019 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9165 10.1336 0.4341 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1841 13.1244 0.6214 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4571 11.7873 0.5328 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7191 14.8696 0.7251 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6805 13.8159 0.6445 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4901 15.2119 0.7362 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1468 12.1891 0.5480 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1291 17.0300 0.8432 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0337 19.4854 2.5517 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0239 19.6722 -0.5656 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3221 20.4248 1.0428 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4390 17.7928 2.4601 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1249 16.7712 4.1051 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4292 17.9805 -0.6730 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1056 17.1621 -2.4263 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4524 14.1645 0.6554 N 0 0 3 0 0 0 0 0 0 0 0 0 15.6063 12.8458 0.5679 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0944 11.3511 0.4796 O 0 0 0 0 0 0 0 0 0 0 0 0 17.3277 13.1845 0.5786 N 0 0 3 0 0 0 0 0 0 0 0 0 18.5820 11.7512 0.4836 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3020 10.7350 -1.2062 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4329 12.4855 0.5177 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3210 10.5363 2.0399 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7314 8.0451 0.3181 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8783 7.5955 0.3008 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6760 5.6178 0.1812 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7407 5.1483 0.1631 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5465 3.2495 0.0482 N 0 0 0 0 0 0 0 0 0 0 0 0 1.7297 2.7277 0.3369 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3050 2.8484 2.2789 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1890 2.5952 -1.6297 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4541 0.6246 -1.5165 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4115 13.6362 0.6615 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7792 15.9127 0.7935 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2747 20.0777 3.8037 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2568 20.4098 -1.7395 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7875 21.7492 1.1206 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3113 16.0828 4.4683 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7542 17.6579 5.1489 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0820 15.8339 3.8880 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7651 17.4063 -2.8220 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9907 17.7249 -3.3816 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3266 15.7630 -2.3431 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8608 15.3571 0.7261 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7360 14.3772 0.6493 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4879 11.6005 -2.3150 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2352 9.6686 -1.2770 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9832 10.2118 -1.2305 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6324 13.2095 1.7215 H 0 0 0 0 0 0 0 0 0 0 0 0 21.3662 11.4192 0.4469 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6189 13.3512 -0.5911 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0022 10.0132 2.0157 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2542 9.4698 1.9692 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5204 11.2604 3.2437 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6029 7.1334 0.2576 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2673 8.0622 1.4933 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2545 8.2034 -0.8193 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2870 5.1512 -1.0114 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2998 5.0099 1.3013 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1297 5.6148 1.3556 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1169 5.7561 -0.9570 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8688 3.5900 -0.3900 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5451 1.3923 -0.1056 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.3414 2.5101 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2462 2.0856 3.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3659 4.2041 2.6931 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2422 2.8875 -2.6452 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4237 3.2215 -1.9401 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9124 0.1363 -2.7673 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4150 0.3335 -0.5140 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2233 0.0000 -1.1873 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 27 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 19 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 17 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 38 1 0 0 0 0 13 17 2 0 0 0 0 13 14 1 0 0 0 0 13 39 1 0 0 0 0 14 40 1 0 0 0 0 15 16 1 0 0 0 0 16 41 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 21 2 0 0 0 0 22 23 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 25 1 0 0 0 0 23 26 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 33 67 1 0 0 0 0 33 68 1 0 0 0 0 33 69 1 0 0 0 0 34 35 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 35 74 1 0 0 0 0 M END > (327) 326 > (327) C27H39N7O > (327) 477.6514 > (327) FGFR-P326 > (327) 6-arylpyrido[2,3-d]pyrimidine deriv. 17 > (327) FGFR-1 Tyrosine Kinase > (327) 340 > (327) BINDDB > (327) <2007 > (327) P > (327) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 20 csChFnd70/04170815452D 52 54 0 0 0 0 0 0 0 0999 V2000 7.4985 12.7968 0.6086 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3291 9.8776 0.4253 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0904 11.1135 0.5075 N 0 0 0 0 0 0 0 0 0 0 0 0 10.0264 10.2475 0.4391 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2852 13.2714 0.6284 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5725 11.9197 0.5387 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8258 15.0371 0.7333 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8208 13.9719 0.6518 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6154 15.3841 0.7446 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2811 12.3260 0.5541 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2602 17.2225 0.8528 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1740 19.7079 2.5804 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1640 19.8967 -0.5716 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4651 20.6575 1.0547 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5735 17.9947 2.4884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5635 18.1847 -0.6810 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1757 16.6990 4.5759 Br 0 0 0 0 0 0 0 0 0 0 0 0 12.1536 17.1466 -2.9058 Br 0 0 0 0 0 0 0 0 0 0 0 0 14.6059 14.3239 0.6628 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8170 8.1351 0.3217 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9432 7.6804 0.3042 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7389 5.6806 0.1832 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7821 5.2057 0.1649 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5860 3.2856 0.0487 N 0 0 0 0 0 0 0 0 0 0 0 0 1.7490 2.7578 0.3406 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3194 2.8798 2.3043 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2357 2.6241 -1.6479 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5038 0.6317 -1.5334 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4821 13.7888 0.6689 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8748 16.0913 0.8025 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4175 20.3070 3.8462 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3989 20.6432 -1.7583 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9343 21.9971 1.1335 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4459 13.3646 0.5991 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0183 15.5299 0.7342 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6982 7.2134 0.2605 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3253 8.1522 1.5099 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3124 8.2950 -0.8284 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3568 5.2089 -1.0227 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3696 5.0662 1.3158 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1641 5.6774 1.3707 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1514 5.8202 -0.9677 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8783 3.6297 -0.3943 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5625 1.4075 -0.1067 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2714 2.1085 3.0508 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3808 4.2505 2.7231 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.3670 2.5380 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2783 2.9196 -2.6748 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4842 3.2575 -1.9617 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4756 0.3373 -0.5198 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2594 0.0000 -1.2005 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9675 0.1380 -2.7981 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 29 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 20 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 30 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 19 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 31 1 0 0 0 0 13 16 2 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 33 1 0 0 0 0 15 17 1 0 0 0 0 16 18 1 0 0 0 0 19 34 1 0 0 0 0 19 35 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 28 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 M END > (329) 328 > (329) C20H24Br2N6 > (329) 508.2578 > (329) FGFR-P328 > (329) 6-arylpyrido[2,3-d]pyrimidine deriv. 20 > (329) FGFR-1 Tyrosine Kinase > (329) 8300 > (329) BINDDB > (329) <2007 > (329) P > (329) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 21 csChFnd70/04170815452D 68 70 0 0 0 0 0 0 0 0999 V2000 7.5249 12.6208 -0.3197 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3133 9.7319 -0.2644 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1058 10.9647 -0.2812 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9888 10.0784 -0.2849 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2901 13.0700 -0.3430 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 11.7225 -0.3242 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8409 14.8055 -0.3848 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7796 13.7222 -0.3852 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6084 15.1280 -0.4060 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2313 12.1052 -0.3459 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2635 16.9345 -0.4508 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1953 19.5048 1.0412 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1775 19.4341 -2.0685 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4876 20.3098 -0.5345 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5853 17.8220 1.0915 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5674 17.7510 -2.0353 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1865 16.7239 3.2470 Br 0 0 0 0 0 0 0 0 0 0 0 0 12.1456 16.5556 -4.1341 Br 0 0 0 0 0 0 0 0 0 0 0 0 7.7911 8.0184 -0.2233 N 0 0 3 0 0 0 0 0 0 0 0 0 5.9407 7.5898 -0.1991 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7190 5.6190 -0.1548 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7866 5.1714 -0.1297 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5737 3.2791 -0.0871 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2279 2.5551 1.5485 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4685 0.5957 1.3551 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7547 2.7903 -0.3708 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3083 2.9913 -2.2931 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5480 14.0509 -0.4071 N 0 0 3 0 0 0 0 0 0 0 0 0 15.6838 12.7230 -0.3882 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1587 11.2372 -0.3520 O 0 0 0 0 0 0 0 0 0 0 0 0 17.4017 13.0421 -0.4096 N 0 0 3 0 0 0 0 0 0 0 0 0 18.6362 11.5987 -0.3891 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3416 10.4539 -1.9821 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4874 12.3112 -0.4198 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3690 10.5233 1.2564 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5339 13.6099 -0.3388 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9155 15.8563 -0.4004 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4450 20.1935 2.2346 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4134 20.0679 -3.2948 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9648 21.6259 -0.5671 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6497 7.0995 -0.2104 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3407 8.1572 0.9478 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3222 8.1076 -1.3595 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3190 5.0516 -1.3018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3377 5.1012 1.0055 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1866 5.7388 1.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1679 5.6890 -1.2901 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4686 3.1531 1.8656 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3012 2.8161 2.5832 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4095 0.3352 0.3334 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9358 0.0556 2.5747 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2317 0.0000 1.0194 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5620 1.4458 0.0196 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9163 3.6291 0.3978 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5096 -2.5257 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3785 4.3562 -2.6530 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2277 2.2512 -3.0703 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9670 15.2363 -0.4360 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8208 14.2276 -0.4385 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5321 11.2201 -3.1544 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2602 9.3801 -1.9670 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0228 9.9463 -1.9602 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6973 13.1267 0.7151 H 0 0 0 0 0 0 0 0 0 0 0 0 21.4058 11.2372 -0.4047 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6778 13.0773 -1.5921 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0502 10.0156 1.2784 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2875 9.4493 1.2717 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5788 11.3387 2.3914 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 38 1 0 0 0 0 13 16 2 0 0 0 0 13 14 1 0 0 0 0 13 39 1 0 0 0 0 14 40 1 0 0 0 0 15 17 1 0 0 0 0 16 18 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 22 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (330) 329 > (330) C25H33Br2N7O > (330) 607.39 > (330) FGFR-P329 > (330) 6-arylpyrido[2,3-d]pyrimidine deriv. 21 > (330) FGFR-1 Tyrosine Kinase > (330) 190 > (330) BINDDB > (330) <2007 > (330) P > (330) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 27 csChFnd70/04170815452D 59 61 0 0 0 0 0 0 0 0999 V2000 2.9947 11.6922 -0.3269 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1056 9.5511 -0.3696 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4440 10.0368 -0.2982 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3985 10.6776 -0.4723 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3155 12.9529 -0.4353 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0742 12.3895 -0.5091 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9423 14.7425 -0.4727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0423 15.2382 -0.6502 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3272 15.8931 -0.5815 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3595 13.5534 -0.6132 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0099 17.7964 -0.6260 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6453 20.5184 0.8701 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4170 21.3524 -0.7092 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9415 18.7456 0.9203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7860 18.6463 -2.2148 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4908 20.4197 -2.2476 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2271 17.7011 2.9039 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.8790 17.4781 -4.1470 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4930 7.7947 -0.3339 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0878 6.5103 -0.2197 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8644 4.6764 -0.2020 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4554 3.3886 -0.0876 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1193 1.6187 -0.3766 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4696 1.3500 -2.3186 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5467 3.5143 1.5903 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8064 2.5523 1.4767 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4253 16.3947 -0.7592 N 0 0 3 0 0 0 0 0 0 0 0 0 10.0710 15.7904 -0.8258 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3438 14.2320 -0.7905 O 0 0 0 0 0 0 0 0 0 0 0 0 11.4144 16.9138 -0.9316 N 0 0 3 0 0 0 0 0 0 0 0 0 13.2034 16.2570 -1.0042 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4694 17.7902 -1.1190 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6419 12.0711 -0.2740 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6165 15.2075 -0.4186 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5925 21.2549 2.0664 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1858 22.7389 -0.7416 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3168 21.0793 -3.4769 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6953 7.4121 -0.3845 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3488 6.7226 0.9727 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2281 6.6491 -1.3400 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6034 4.4641 -1.3945 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7241 4.5377 0.9182 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3248 1.4413 0.3504 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1571 0.6744 0.0656 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5219 2.2071 -2.7325 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8403 0.0000 -2.5500 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2961 1.6514 -3.0571 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3458 2.9280 2.6058 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3136 4.8790 1.9009 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1508 0.4744 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0385 1.1919 1.1472 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1410 2.6292 2.7276 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2076 17.6382 -0.7873 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1968 18.1575 -0.9598 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4782 15.5033 0.1661 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3575 15.4298 -2.1466 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1945 18.5441 -2.2892 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3152 18.6175 0.0234 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8003 17.3016 -1.1729 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 33 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 34 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 27 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 35 1 0 0 0 0 13 16 1 0 0 0 0 13 36 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 37 1 0 0 0 0 19 20 1 0 0 0 0 19 38 1 0 0 0 0 20 21 1 0 0 0 0 20 39 1 0 0 0 0 20 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 21 42 1 0 0 0 0 22 23 1 0 0 0 0 22 25 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 31 1 0 0 0 0 30 54 1 0 0 0 0 31 32 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 M END > (333) 332 > (333) C22H27Cl2N7O > (333) 476.4076 > (333) FGFR-P332 > (333) 6-arylpyrido[2,3-d]pyrimidine deriv. 27 > (333) FGFR-1 Tyrosine Kinase > (333) 1300 > (333) BINDDB > (333) <2007 > (333) P > (333) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 28 csChFnd70/04170815452D 65 67 0 0 0 0 0 0 0 0999 V2000 2.9172 11.5959 0.2032 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0433 9.4864 0.1882 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3815 9.9517 0.1763 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3213 10.6233 0.2270 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2218 12.8666 0.2450 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9811 12.3250 0.2566 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8320 14.6453 0.2749 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9185 15.1739 0.3241 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2019 15.8071 0.3149 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2513 13.4989 0.2956 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8668 17.6997 0.3469 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3764 20.3269 1.9470 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2406 21.2358 0.4070 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6884 18.5635 1.9258 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7360 18.6250 -1.2012 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4236 20.3879 -1.1626 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8576 17.4247 3.8599 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9659 17.5634 -3.1726 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4467 7.7409 0.1592 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0580 6.4457 0.1164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8504 4.6272 0.0909 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4580 3.3286 0.0480 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4870 3.4227 -1.5879 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7701 2.4480 -1.3946 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1496 1.5768 0.3313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5769 1.3375 2.2536 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2862 16.3415 0.3642 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9333 15.7581 0.3735 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2205 14.2085 0.3468 O 0 0 0 0 0 0 0 0 0 0 0 0 11.2619 16.8924 0.4124 N 0 0 3 0 0 0 0 0 0 0 0 0 13.3837 15.1876 -1.2143 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2998 17.7998 0.4684 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0522 16.2580 0.4225 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3430 15.1244 2.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5647 11.9585 0.1875 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5056 15.0936 0.2666 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2384 20.9974 3.1684 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9965 22.6143 0.4304 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3215 21.1059 -2.3605 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6493 7.3733 0.1671 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2447 6.5891 1.2632 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2737 6.6342 -1.0439 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6639 4.4840 -1.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6347 4.4389 1.2512 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2277 4.7753 -1.9046 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2490 2.8343 -2.6225 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0290 1.0998 -1.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0481 -0.3730 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0582 2.5015 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1850 0.6206 -0.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3229 1.4034 -0.4372 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9698 0.0000 2.4858 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6308 2.2075 2.6137 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4345 1.6347 3.0306 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0569 17.5781 0.3854 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0328 18.1288 0.4337 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1767 15.9953 -2.3553 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7158 14.7157 -1.2068 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4951 14.0894 -1.2470 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0635 18.5624 1.6346 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6318 17.3278 0.4759 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0926 18.6073 -0.6726 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4543 14.0260 1.9915 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6751 14.6524 2.0317 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1068 15.8870 3.1902 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 35 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 36 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 27 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 37 1 0 0 0 0 13 16 1 0 0 0 0 13 38 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 25 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 25 26 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 28 1 0 0 0 0 27 55 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 33 1 0 0 0 0 30 56 1 0 0 0 0 31 33 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (334) 333 > (334) C24H31Cl2N7O > (334) 504.4612 > (334) FGFR-P333 > (334) 6-arylpyrido[2,3-d]pyrimidine deriv. 28 > (334) FGFR-1 Tyrosine Kinase > (334) 1800 > (334) BINDDB > (334) <2007 > (334) P > (334) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 29 csChFnd70/04170815452D 62 64 0 0 0 0 0 0 0 0999 V2000 2.9354 13.3977 1.2137 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7730 11.0296 1.0351 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1836 11.7132 1.0252 N 0 0 0 0 0 0 0 0 0 0 0 0 6.1888 11.9781 1.2314 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3950 14.4747 1.4281 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0713 13.7027 1.4322 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2382 16.2820 1.6361 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3704 16.3861 1.8296 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7483 17.2427 1.8387 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4841 14.6888 1.6324 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6606 19.1549 2.0626 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4476 21.6546 3.9227 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4965 22.7278 2.4810 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5289 19.8720 3.7228 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7168 20.2446 0.6145 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6346 22.0251 0.8318 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4666 18.5272 5.5338 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.8906 19.3651 -1.4564 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9477 9.2533 0.8319 N 0 0 3 0 0 0 0 0 0 0 0 0 3.4017 8.1635 0.6116 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9530 6.2627 0.4153 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8792 17.3530 2.0330 N 0 0 3 0 0 0 0 0 0 0 0 0 10.4386 16.5547 2.0273 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5233 14.9873 1.8440 O 0 0 0 0 0 0 0 0 0 0 0 0 11.9043 17.4939 2.2249 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0372 17.9782 2.4642 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5994 16.6262 2.2188 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3383 5.1245 0.1852 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6581 2.6463 1.6076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6457 0.9627 1.2262 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8676 3.2994 -0.0032 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3913 2.2098 -0.5318 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0102 2.5006 -2.4620 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6401 13.9389 1.1979 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9794 16.9037 1.6374 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3461 22.2115 5.2074 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4327 24.1208 2.6441 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6775 22.8703 -0.2884 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0941 8.7281 0.8352 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5638 8.2973 1.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6965 8.5729 -0.5471 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7908 6.1288 -0.7195 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6582 5.8533 1.5741 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8117 18.6035 2.1793 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8367 18.7445 2.3712 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9850 18.9204 1.4073 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8523 18.6449 3.7008 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2983 17.3325 2.4597 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6515 15.6840 3.2758 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7842 15.9595 0.9822 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5005 5.2584 1.3199 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6331 5.5338 -0.9736 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6428 2.3922 2.5626 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5563 3.6152 2.1195 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2162 0.4678 2.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7513 0.0000 0.6962 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6734 1.2207 0.2855 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7085 0.8462 -0.3133 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2501 2.5576 0.2326 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5701 3.8328 -2.6610 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1888 2.2751 -3.2154 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6015 -2.8847 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 28 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 23 25 1 0 0 0 0 23 24 2 0 0 0 0 25 27 1 0 0 0 0 25 45 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 31 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (335) 334 > (335) C23H29Cl2N7O > (335) 490.4344 > (335) FGFR-P334 > (335) 6-arylpyrido[2,3-d]pyrimidine deriv. 29 > (335) FGFR-1 Tyrosine Kinase > (335) 130 > (335) BINDDB > (335) <2007 > (335) P > (335) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 30 csChFnd70/04170815452D 65 67 0 0 0 0 0 0 0 0999 V2000 6.6483 13.2268 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7223 10.3748 -0.0352 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3815 11.5087 -0.0423 N 0 0 0 0 0 0 0 0 0 0 0 0 9.3868 10.8860 -0.0346 N 0 0 0 0 0 0 0 0 0 0 0 0 8.3939 13.8506 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7928 12.6048 -0.0412 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7865 15.6618 -0.0563 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8669 14.8447 -0.0483 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5463 16.1572 -0.0561 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4655 13.1536 -0.0412 N 0 0 0 0 0 0 0 0 0 0 0 0 11.0376 18.0505 -0.0645 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7252 20.7165 1.5061 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9559 21.5881 -0.0804 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2673 18.9526 1.5230 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2796 18.9351 -1.6600 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7374 20.6992 -1.6589 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9778 17.8610 3.5155 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.0070 17.8214 -3.6427 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3566 8.5885 -0.0277 N 0 0 3 0 0 0 0 0 0 0 0 0 5.5228 7.9776 -0.0276 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4860 5.9594 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6271 15.3463 -0.0480 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9044 14.1092 -0.0405 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5139 12.5536 -0.0342 O 0 0 0 0 0 0 0 0 0 0 0 0 16.6144 14.5967 -0.0402 N 0 0 3 0 0 0 0 0 0 0 0 0 18.3732 12.6561 -1.9249 C 0 0 0 0 0 0 0 0 0 0 0 0 18.0026 13.2519 -0.0322 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5709 5.3212 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7409 2.7230 0.3048 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2781 2.9362 2.2581 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5355 3.3835 -0.0098 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2597 2.6683 -1.6590 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6915 0.7119 -1.4117 C 0 0 0 0 0 0 0 0 0 0 0 0 19.6849 14.0262 0.7711 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5500 14.1347 -0.0607 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7487 16.6382 -0.0628 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9040 21.4162 2.7345 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3139 22.9673 -0.0866 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9248 21.3857 -2.8933 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3139 7.7393 -0.0226 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8522 8.4745 1.1433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8555 8.4640 -1.2049 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1568 5.4624 -1.1895 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1534 5.4730 1.1587 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9388 16.5876 -0.0530 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9259 15.8379 -0.0454 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4061 11.6555 -1.9190 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1748 12.1045 -2.4973 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8028 13.7839 -2.7070 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5730 12.1242 0.7499 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9002 5.8183 1.1525 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9036 5.8077 -1.1958 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6718 1.3324 -0.0552 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8079 3.4715 -0.4933 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.3302 2.5168 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2840 2.2955 3.0616 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2209 4.3350 2.5872 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2913 2.8162 -2.7118 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4582 3.3834 -2.0063 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6743 0.5656 -0.3723 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4967 0.0000 -1.0454 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2105 0.1765 -2.6413 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4208 14.4507 2.1194 H 0 0 0 0 0 0 0 0 0 0 0 0 20.7178 13.0257 0.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1144 15.1540 -0.0111 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 35 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 36 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 37 1 0 0 0 0 13 16 1 0 0 0 0 13 38 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 28 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 23 25 1 0 0 0 0 23 24 2 0 0 0 0 25 27 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 34 1 0 0 0 0 27 50 1 0 0 0 0 28 31 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (336) 335 > (336) C24H31Cl2N7O > (336) 504.4612 > (336) FGFR-P335 > (336) 6-arylpyrido[2,3-d]pyrimidine deriv. 30 > (336) FGFR-1 Tyrosine Kinase > (336) 77 > (336) BINDDB > (336) <2007 > (336) P > (336) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 32 csChFnd70/04170815452D 65 67 0 0 0 0 0 0 0 0999 V2000 3.7273 15.0356 -0.4694 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8621 12.8701 -0.5126 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1816 13.3613 -0.4405 N 0 0 0 0 0 0 0 0 0 0 0 0 7.1696 14.0095 -0.6165 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0632 16.3104 -0.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8417 15.7407 -0.6537 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6856 18.1203 -0.6167 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8207 18.6216 -0.7963 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0864 19.2839 -0.7268 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1415 16.9177 -0.7589 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7653 21.2085 -0.7718 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3966 23.9616 0.7411 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1657 24.8049 -0.8559 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6961 22.1687 0.7919 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5389 22.0683 -2.3787 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2404 23.8617 -2.4117 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9849 21.1122 2.7979 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6329 20.8867 -4.3327 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.2540 11.0938 -0.4765 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8329 9.7951 -0.3611 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6182 7.9404 -0.3432 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1341 6.5840 -0.2226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9194 4.7292 -0.2047 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4945 3.4269 -0.0890 N 0 0 0 0 0 0 0 0 0 0 0 0 4.1659 1.6370 -0.3812 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5203 1.3652 -2.3453 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5756 3.5540 1.6080 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8156 2.5812 1.4930 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2193 19.7912 -0.9065 N 0 0 3 0 0 0 0 0 0 0 0 0 10.8837 19.1800 -0.9740 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1595 17.6039 -0.9384 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2423 20.3163 -1.0810 N 0 0 3 0 0 0 0 0 0 0 0 0 14.0514 19.6519 -1.1545 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3318 21.2025 -1.2704 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3592 15.4187 -0.4160 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3449 18.5905 -0.5622 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3432 24.7064 1.9510 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9319 26.2070 -0.8889 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0644 24.5287 -3.6549 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4698 10.7070 -0.5277 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0854 10.0097 0.8447 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9634 9.9355 -1.4941 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3656 7.7257 -1.5492 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4876 7.8000 0.7896 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3867 6.7986 0.9835 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2646 6.7243 -1.3556 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6667 4.5146 -1.4108 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7888 4.5889 0.9283 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3850 1.4576 0.3540 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1927 0.6820 0.0660 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5845 2.2319 -2.7639 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8952 0.0000 -2.5792 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3333 1.6700 -3.0922 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3836 2.9610 2.6349 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3397 4.9340 1.9220 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1426 2.6589 2.7580 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1864 0.4793 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0505 1.2054 1.1598 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9993 21.0487 -0.9349 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0222 21.5737 -1.1096 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3294 18.8896 0.0291 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2073 18.8154 -2.3097 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0538 21.9648 -2.4540 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1760 22.0392 -0.1151 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6778 20.7083 -1.3251 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 35 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 36 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 37 1 0 0 0 0 13 16 1 0 0 0 0 13 38 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 28 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 56 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (337) 336 > (337) C24H31Cl2N7O > (337) 504.4612 > (337) FGFR-P336 > (337) 6-arylpyrido[2,3-d]pyrimidine deriv. 32 > (337) FGFR-1 Tyrosine Kinase > (337) 49 > (337) BINDDB > (337) <2007 > (337) P > (337) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 33 csChFnd70/04170815452D 71 73 0 0 0 0 0 0 0 0999 V2000 3.5902 14.8301 0.2741 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7254 12.7116 0.2591 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0564 13.1788 0.2471 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0089 13.8533 0.2982 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9005 16.1062 0.3162 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6674 15.5623 0.3279 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5090 17.8925 0.3461 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6088 18.4234 0.3956 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8847 19.0593 0.3863 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9430 16.7413 0.3669 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5483 20.9598 0.4185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0557 23.5984 2.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9193 24.5113 0.4788 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3691 21.8276 2.0040 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4169 21.8893 -1.1364 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1031 23.6598 -1.0975 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5390 20.6839 3.9465 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6479 20.8231 -3.1161 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.1306 10.9586 0.2300 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7360 9.6578 0.1870 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5319 7.8317 0.1613 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0753 6.4733 0.1165 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8710 4.6471 0.0909 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4728 3.3428 0.0478 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4975 3.4374 -1.5950 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7735 2.4584 -1.4010 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1672 1.5834 0.3324 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5964 1.3432 2.2629 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9824 19.5961 0.4358 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6364 19.0100 0.4452 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9249 17.4538 0.4184 O 0 0 0 0 0 0 0 0 0 0 0 0 11.9707 20.1491 0.4843 N 0 0 3 0 0 0 0 0 0 0 0 0 14.1017 18.4372 -1.1494 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0215 21.0605 0.5405 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7687 19.5122 0.4944 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0607 18.3737 2.1028 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2320 15.1941 0.2583 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1768 18.3428 0.3378 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9171 24.2718 3.2521 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6742 25.8957 0.5024 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0006 24.3808 -2.3005 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3385 10.5895 0.2380 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9191 9.8018 1.3387 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9484 9.8470 -0.9784 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3487 7.6877 -0.9903 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3195 7.6425 1.3267 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2585 6.6172 1.2681 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2876 6.6625 -1.0489 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6880 4.5030 -1.0608 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6588 4.4579 1.2562 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2371 4.7958 -1.9131 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2628 2.8465 -2.6341 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0585 2.5122 -2.6259 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0334 1.1044 -1.0642 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0610 -0.3750 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1987 0.6232 -0.0600 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3455 1.4094 -0.4395 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9910 0.0000 2.4962 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6549 2.2167 2.6245 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4492 1.6415 3.0432 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7522 20.8377 0.4572 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7406 21.3910 0.5056 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8937 19.2484 -2.2953 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4394 17.9632 -1.1417 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2091 17.3343 -1.1822 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7843 21.8264 1.7115 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3593 20.5865 0.5481 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8135 21.8716 -0.6055 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1681 17.2707 2.0700 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3984 17.8997 2.1105 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8235 19.1396 3.2741 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 20 21 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 22 1 0 0 0 0 21 45 1 0 0 0 0 21 46 1 0 0 0 0 22 23 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 23 50 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 28 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 35 1 0 0 0 0 32 62 1 0 0 0 0 33 35 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 35 36 1 0 0 0 0 36 69 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 M END > (338) 337 > (338) C26H35Cl2N7O > (338) 532.5148 > (338) FGFR-P337 > (338) 6-arylpyrido[2,3-d]pyrimidine deriv. 33 > (338) FGFR-1 Tyrosine Kinase > (338) 48 > (338) BINDDB > (338) <2007 > (338) P > (338) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 34 csChFnd70/04170815452D 75 78 0 0 0 0 0 0 0 0999 V2000 3.6623 15.1278 0.2796 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8403 12.9668 0.2643 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1379 13.4434 0.2521 N 0 0 0 0 0 0 0 0 0 0 0 0 7.1497 14.1313 0.3042 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9989 16.4295 0.3225 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8013 15.8748 0.3345 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5996 18.2517 0.3530 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7615 18.7932 0.4035 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0028 19.4420 0.3941 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1025 17.0773 0.3743 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6596 21.3806 0.4269 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1571 24.0721 2.0660 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0182 25.0033 0.4884 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4768 22.2657 2.0442 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5256 22.3286 -1.1591 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2055 24.1348 -1.1195 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6502 21.0992 4.0257 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7612 21.2412 -3.1786 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.2536 11.1786 0.2346 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8311 9.8517 0.1907 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6429 7.9889 0.1646 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1572 6.6032 0.1189 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9689 4.7404 0.0927 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5424 3.4099 0.0487 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5477 3.5063 -1.6270 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7890 2.5078 -1.4291 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2509 1.6152 0.3391 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6887 1.3701 2.3083 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1627 19.9895 0.4446 N 0 0 3 0 0 0 0 0 0 0 0 0 10.8499 19.3916 0.4541 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1443 17.8043 0.4268 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2110 20.5536 0.4940 N 0 0 3 0 0 0 0 0 0 0 0 0 14.0450 19.9040 0.5043 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2734 21.3299 -0.2622 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1888 20.6513 -0.2514 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7476 20.2304 1.6565 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5192 18.8044 2.4232 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6038 19.4830 2.4123 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2768 15.4992 0.2635 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2405 18.7110 0.3446 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0159 24.7590 3.3173 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7680 26.4157 0.5124 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1010 24.8702 -2.3467 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4858 10.8021 0.2428 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9978 9.9986 1.3655 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0277 10.0447 -0.9980 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4761 7.8420 -1.0101 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4463 7.7959 1.3534 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3238 6.7501 1.2935 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3536 6.7962 -1.0698 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8021 4.5935 -1.0820 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7724 4.5474 1.2814 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2820 4.8921 -1.9515 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3282 2.9036 -2.6870 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0541 1.1265 -1.0855 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.1224 -0.3825 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0597 2.5627 -2.6786 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2628 0.6357 -0.0612 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4528 1.4377 -0.4483 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7684 2.2613 2.6772 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5184 1.6745 3.1043 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0912 0.0000 2.5463 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9279 21.2560 0.4664 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9762 21.8204 0.5158 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1367 18.7044 -0.3011 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8753 21.6298 -1.6215 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1817 22.5295 0.5431 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2803 19.4517 -1.0567 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0638 21.6671 -0.7975 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1122 19.7469 1.6644 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6560 21.4299 2.4620 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6109 17.6049 1.6177 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9173 18.5045 3.7825 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5123 20.6826 3.2177 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7288 18.4672 2.9585 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 38 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 35 36 1 0 0 0 0 35 68 1 0 0 0 0 35 69 1 0 0 0 0 36 37 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 37 38 1 0 0 0 0 37 72 1 0 0 0 0 37 73 1 0 0 0 0 38 74 1 0 0 0 0 38 75 1 0 0 0 0 M END > (339) 338 > (339) C28H37Cl2N7O > (339) 558.5526 > (339) FGFR-P338 > (339) 6-arylpyrido[2,3-d]pyrimidine deriv. 34 > (339) FGFR-1 Tyrosine Kinase > (339) 43 > (339) BINDDB > (339) <2007 > (339) P > (339) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 35 csChFnd70/04170815452D 69 72 0 0 0 0 0 0 0 0999 V2000 3.0095 14.7818 -0.3768 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2242 12.7498 -0.0916 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5452 13.1458 -0.3166 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4500 13.9507 0.0840 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2556 16.1188 -0.1972 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0354 15.6501 0.0409 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7882 17.8937 -0.2477 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8456 18.5610 0.1721 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1043 19.1238 -0.0600 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2514 16.8882 0.2150 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6865 21.0156 -0.1035 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8895 23.6609 1.3891 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9074 24.5506 -0.1846 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2768 21.8983 1.4383 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7091 21.9219 -1.6853 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3194 23.6845 -1.7169 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2530 20.7836 3.4145 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2266 20.8372 -3.6098 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.7039 11.0091 -0.0392 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3749 9.6436 -0.2296 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2458 7.8465 -0.1246 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8579 6.4205 -0.3234 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7287 4.6234 -0.2183 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3962 3.2543 -0.4092 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6243 3.2856 -2.1669 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9221 2.2361 -2.1663 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1254 1.5237 -0.0088 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3257 1.3266 1.9712 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1590 19.7969 0.3596 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8287 19.2810 0.5823 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1835 17.7325 0.6191 O 0 0 0 0 0 0 0 0 0 0 0 0 11.1047 20.4817 0.7644 N 0 0 3 0 0 0 0 0 0 0 0 0 12.8524 19.9513 0.8611 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4104 18.4865 -0.0542 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1363 17.9667 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3083 18.9029 1.0519 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7567 20.3617 1.9653 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0343 20.8929 1.8666 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6444 15.0879 -0.5657 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4447 18.2874 -0.4275 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5725 24.3460 2.5819 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6031 25.9288 -0.2162 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3359 24.3875 -2.9408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9205 10.6913 0.1235 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4139 9.7674 0.8148 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7268 9.7842 -1.4906 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2070 7.7228 -1.1690 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8941 7.7059 1.1363 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8969 6.5443 0.7211 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2098 6.5611 -1.5843 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6898 4.4996 -1.2627 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3769 4.4828 1.0426 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3514 4.6328 -2.5417 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5371 2.7096 -3.0969 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1911 0.8953 -1.7667 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.8271 -1.2553 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3626 2.2379 -3.4765 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2489 0.5138 -0.5002 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4002 1.3900 -0.6306 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7459 0.0000 2.2762 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2985 2.2536 2.4447 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0755 1.5861 2.6031 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8759 21.0323 0.3302 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8117 21.7136 0.8283 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4954 17.7543 -0.8412 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5710 16.8277 -0.6680 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6572 18.4935 1.1265 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6752 21.0898 2.7521 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6056 22.0358 2.5757 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 29 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 22 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 25 1 0 0 0 0 24 27 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 64 1 0 0 0 0 33 34 2 0 0 0 0 33 38 1 0 0 0 0 34 35 1 0 0 0 0 34 65 1 0 0 0 0 35 36 2 0 0 0 0 35 66 1 0 0 0 0 36 37 1 0 0 0 0 36 67 1 0 0 0 0 37 38 2 0 0 0 0 37 68 1 0 0 0 0 38 69 1 0 0 0 0 M END > (340) 339 > (340) C28H31Cl2N7O > (340) 552.5052 > (340) FGFR-P339 > (340) 6-arylpyrido[2,3-d]pyrimidine deriv. 35 > (340) FGFR-1 Tyrosine Kinase > (340) 110 > (340) BINDDB > (340) <2007 > (340) P > (340) TRAIN $$$$ 1,6-naphthyridin 20 csChFnd70/04170815452D 83 86 0 0 0 0 0 0 0 0999 V2000 1.2227 15.9686 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 13.3593 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3129 14.1638 -0.0272 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7816 16.9031 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3768 15.9823 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8076 18.7259 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9356 18.5438 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4043 19.5462 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2459 14.2662 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8823 16.8380 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5052 21.4658 0.0078 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6348 24.2216 -1.1646 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5380 22.4281 -1.1759 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5620 22.3117 1.2041 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6528 24.1056 1.2085 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6932 25.0596 0.0237 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6916 25.1613 -2.3186 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8535 27.0048 -2.2341 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6825 24.9316 2.3753 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7143 26.7826 2.3069 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5321 19.3750 -0.0323 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0056 18.4363 -0.0520 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9368 16.8616 -0.0592 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5554 19.2430 -0.0635 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1571 18.2225 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1959 17.0869 -1.7108 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7195 19.4446 -0.0946 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2288 17.0706 1.5281 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6344 11.5589 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2361 10.5384 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7886 8.6059 -0.0534 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4611 7.5400 -0.0752 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0136 5.6076 -0.0820 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9458 1.7055 0.0649 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2569 2.7383 0.1989 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8691 5.2480 1.1731 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5579 4.2153 1.0392 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6197 4.5841 -0.1029 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1951 2.3695 1.3409 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8012 1.3460 1.3201 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.6504 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4916 13.4081 -0.0421 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6180 19.4639 0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7139 21.7767 -2.1018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3089 21.5699 2.1272 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7667 26.4577 0.0297 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0350 27.5955 -3.2231 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4489 27.4551 -0.9572 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2003 27.3702 -2.4575 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1705 27.1993 1.0358 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4119 27.2846 2.5276 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5847 27.2760 3.3048 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5869 20.6312 -0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6103 20.4994 -0.0578 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1450 17.9076 -2.8600 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3876 16.3277 -1.7267 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0829 16.2164 -1.7039 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6919 20.2536 1.0635 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9112 18.6854 -0.1106 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6684 20.2653 -1.2438 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1157 16.1999 1.5350 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4204 16.3113 1.5122 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2011 17.8795 2.6863 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5191 10.9785 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9804 10.8535 -1.2057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0021 10.8403 1.1018 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0441 8.2908 1.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0226 8.3039 -1.2019 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2056 7.8552 -1.2341 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2273 7.8421 1.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2693 5.2924 1.0770 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2477 5.3056 -1.2304 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6860 0.3411 0.3254 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4814 1.8441 -1.2354 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3416 2.2729 -0.7717 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7031 2.5713 1.4882 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3334 5.1096 2.4734 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1289 6.6124 0.9125 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1118 4.3823 -0.2501 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4733 4.6806 2.0099 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3861 1.4137 0.0355 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7028 1.8651 2.2763 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5060 0.0000 1.6330 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 41 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 29 1 0 0 0 0 3 5 2 0 0 0 0 3 42 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 43 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 44 1 0 0 0 0 14 15 1 0 0 0 0 14 45 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 46 1 0 0 0 0 17 18 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 20 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 22 1 0 0 0 0 21 53 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 24 54 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 25 28 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 28 63 1 0 0 0 0 29 30 1 0 0 0 0 29 64 1 0 0 0 0 30 31 1 0 0 0 0 30 65 1 0 0 0 0 30 66 1 0 0 0 0 31 32 1 0 0 0 0 31 67 1 0 0 0 0 31 68 1 0 0 0 0 32 33 1 0 0 0 0 32 69 1 0 0 0 0 32 70 1 0 0 0 0 33 38 1 0 0 0 0 33 71 1 0 0 0 0 33 72 1 0 0 0 0 34 39 1 0 0 0 0 34 35 1 0 0 0 0 34 73 1 0 0 0 0 34 74 1 0 0 0 0 35 38 1 0 0 0 0 35 75 1 0 0 0 0 35 76 1 0 0 0 0 36 38 1 0 0 0 0 36 37 1 0 0 0 0 36 77 1 0 0 0 0 36 78 1 0 0 0 0 37 39 1 0 0 0 0 37 79 1 0 0 0 0 37 80 1 0 0 0 0 39 40 1 0 0 0 0 40 81 1 0 0 0 0 40 82 1 0 0 0 0 40 83 1 0 0 0 0 M END > (35) 33 > (35) C30H43N7O3 > (35) 549.7148 > (35) FGFR-P33 > (35) 1,6-naphthyridine 20 > (35) FGFR-1 Tyrosine Kinase > (35) 24 > (35) BINDDB > (35) <2007 > (35) P > (35) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 37 csChFnd70/04170815452D 62 64 0 0 0 0 0 0 0 0999 V2000 3.9154 12.2594 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4098 9.6959 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9384 10.5665 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9247 10.4569 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4899 13.1418 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0351 12.1731 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5727 14.9443 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6625 14.6602 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1817 15.7059 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5518 12.9715 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3460 17.6032 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5913 20.2600 1.5565 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6528 21.1487 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4385 18.4923 1.5584 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4161 18.5061 -1.5407 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5692 20.2738 -1.5252 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3607 17.3794 3.4894 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3121 17.4106 -3.4802 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.3486 7.9215 -0.0245 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6876 7.0373 -0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9799 5.0937 -0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2451 4.1700 -0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3495 1.7336 1.5739 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5259 2.3041 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 0.9080 1.3786 -0.3201 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2710 15.4278 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 11.6979 14.4478 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5757 12.8907 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2604 15.1934 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8114 14.1278 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8111 13.0013 -1.6949 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4006 15.2843 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8425 12.9852 1.5145 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7137 12.9525 0.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4179 15.7132 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6635 20.9498 2.7581 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7726 22.5308 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6232 20.9746 -2.7214 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4056 7.2620 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9765 7.3948 1.1393 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9543 7.4063 -1.1470 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6910 4.7362 -1.1775 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7132 4.7246 1.1090 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5340 4.5277 1.1389 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5118 4.5391 -1.1474 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5299 2.0573 2.6622 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5424 0.3474 1.5310 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5872 2.3730 1.7153 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3706 1.7598 -1.5556 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1525 0.0000 -0.3229 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.6895 0.6996 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3685 16.6702 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3579 16.4356 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7891 13.8154 -2.8338 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9652 12.2087 -1.7100 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6790 12.1776 -1.6879 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4008 16.0869 1.0535 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5546 14.4917 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3785 16.0984 -1.2330 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7104 12.1613 1.5213 H 0 0 0 0 0 0 0 0 0 0 0 0 15.9966 12.1924 1.4992 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8426 13.7877 2.6619 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 19 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 26 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 24 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 46 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 27 29 1 0 0 0 0 27 28 2 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 30 31 1 0 0 0 0 30 32 1 0 0 0 0 30 33 1 0 0 0 0 31 54 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (341) 340 > (341) C23H29Cl2N7O > (341) 490.4344 > (341) FGFR-P340 > (341) 6-arylpyrido[2,3-d]pyrimidine deriv. 37 > (341) FGFR-1 Tyrosine Kinase > (341) 75 > (341) BINDDB > (341) <2007 > (341) P > (341) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 39 csChFnd70/04170815452D 65 67 0 0 0 0 0 0 0 0999 V2000 5.8032 9.2473 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3111 6.6604 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8264 7.5390 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 8.8398 7.4285 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3920 10.1378 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9513 9.1602 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4755 11.9567 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5935 11.6700 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0992 12.7252 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4817 9.9660 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2650 14.6399 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5126 17.3209 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5747 18.2176 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3583 15.5370 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3358 15.5510 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4903 17.3349 -1.5391 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2799 14.4140 3.5211 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.2308 14.4456 -3.5119 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.5732 3.9776 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9715 3.6763 -1.8785 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2208 2.7442 -1.8662 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7976 1.2383 -4.5589 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6429 2.4549 -3.6575 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8395 1.8451 -3.7028 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2494 4.8700 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8604 3.8645 -0.0455 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2166 12.4447 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 13.6566 11.4556 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5333 9.8845 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 15.2332 12.2081 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 16.7982 9.9961 -1.7104 C 0 0 0 0 0 0 0 0 0 0 0 0 18.4021 12.2999 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7984 11.1328 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8298 9.9798 1.5284 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5905 9.9468 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3101 12.7326 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5854 18.0170 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6955 19.6124 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5447 18.0420 -2.7462 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6219 4.7712 0.6666 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7061 2.7345 0.6457 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8386 4.9194 -2.5371 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9227 2.8826 -2.5578 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3535 1.5013 -1.2077 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2694 3.5379 -1.1868 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8008 0.0000 -3.8783 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3402 1.0473 -5.8822 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1086 1.7646 -4.5852 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.8128 -3.1066 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4448 1.6414 -5.0441 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7357 0.6289 -2.9912 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2729 3.6084 1.2816 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6426 2.6398 -0.7157 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8643 4.5972 -0.7177 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3150 13.6983 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3316 13.4616 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7759 10.8176 -2.8596 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9628 9.1961 -1.7257 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6557 9.1648 -1.7034 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4024 13.1097 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5667 11.4999 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3798 13.1213 -1.2442 H 0 0 0 0 0 0 0 0 0 0 0 0 15.6873 9.1483 1.5352 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9944 9.1797 1.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8299 10.7895 2.6862 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 35 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 25 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 36 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 27 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 37 1 0 0 0 0 13 16 1 0 0 0 0 13 38 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 39 1 0 0 0 0 19 25 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 23 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 25 26 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 28 1 0 0 0 0 27 55 1 0 0 0 0 28 30 1 0 0 0 0 28 29 2 0 0 0 0 30 33 1 0 0 0 0 30 56 1 0 0 0 0 31 33 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (342) 341 > (342) C24H31Cl2N7O > (342) 504.4612 > (342) FGFR-P341 > (342) 6-arylpyrido[2,3-d]pyrimidine deriv. 39 > (342) FGFR-1 Tyrosine Kinase > (342) 2000 > (342) BINDDB > (342) <2007 > (342) P > (342) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 41 csChFnd70/04170815452D 68 70 0 0 0 0 0 0 0 0999 V2000 2.7787 9.8780 1.2700 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5034 8.6233 1.1566 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7813 8.5079 1.0452 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3134 10.0966 1.4949 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5676 11.4840 1.6338 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4078 11.5609 1.7436 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5888 13.0035 1.8893 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3081 14.5080 2.3312 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4765 14.5299 2.2417 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1976 13.0660 2.0867 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5100 16.1730 2.5220 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0743 18.1731 4.4418 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7040 19.2428 3.0456 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9743 16.6408 4.1893 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1390 17.2610 1.1205 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2381 18.7899 1.3902 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4372 15.2995 5.9430 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.8090 16.6953 -0.9580 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.6243 5.4828 0.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9952 4.0591 0.3152 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0976 2.3293 -0.0785 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9384 2.2946 -3.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9609 2.5336 -1.5985 N 0 0 0 0 0 0 0 0 0 0 0 0 3.4784 1.3344 -1.5102 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4836 7.1392 0.9085 N 0 0 3 0 0 0 0 0 0 0 0 0 8.2107 4.5317 -1.1854 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0479 3.8925 1.9936 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1916 16.0394 2.6844 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9408 16.0405 2.7742 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7443 14.6995 2.5456 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7991 17.5280 3.1172 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7003 17.5292 3.2150 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4537 16.9304 1.4750 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3422 19.3674 3.6174 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2908 16.2911 4.6541 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3829 9.7702 1.1708 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1876 12.9827 1.8129 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6592 18.5369 5.7320 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 20.4397 3.2497 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9498 19.6333 0.3062 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8742 5.6014 -0.6644 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7582 5.1461 1.6004 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0755 1.3409 -0.3497 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3237 1.9333 1.0398 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6255 1.0567 -3.1800 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0420 2.3011 -4.3174 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8729 3.3488 -3.3686 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7249 1.6004 -0.3406 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6580 1.5131 -2.6510 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9519 0.0000 -1.4734 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7407 7.1943 0.9838 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0811 5.5723 -0.7781 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9727 3.3952 -1.5516 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4445 4.9643 -2.2952 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1685 3.6778 3.0832 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9403 2.7981 1.8845 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7847 5.0829 2.2090 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5506 17.1092 2.8667 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1581 18.5979 3.2996 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0330 17.8124 0.4497 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8682 16.9312 1.5477 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9964 15.6208 1.1884 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8055 19.7940 4.8568 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7568 19.3682 3.6900 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9215 20.2495 2.5921 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8335 14.9814 4.3673 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7054 16.2920 4.7268 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7541 16.7177 5.8935 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 25 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 38 1 0 0 0 0 13 16 1 0 0 0 0 13 39 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 40 1 0 0 0 0 19 25 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 20 21 1 0 0 0 0 20 26 1 0 0 0 0 20 27 1 0 0 0 0 21 23 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 24 48 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 M END > (343) 342 > (343) C25H33Cl2N7O > (343) 518.488 > (343) FGFR-P342 > (343) 6-arylpyrido[2,3-d]pyrimidine deriv. 41 > (343) FGFR-1 Tyrosine Kinase > (343) 210 > (343) BINDDB > (343) <2007 > (343) P > (343) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 43 csChFnd70/04170815452D 67 70 0 0 0 0 0 0 0 0999 V2000 3.9711 13.6325 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4790 11.0456 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9943 11.9243 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0076 11.8137 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5599 14.5229 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1191 13.5454 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6434 16.3419 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7613 16.0552 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2670 17.1103 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6496 14.3512 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4328 19.0250 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6803 21.7060 1.5707 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7424 22.6027 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5262 19.9221 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5035 19.9361 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6581 21.7200 -1.5391 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4477 18.7992 3.5211 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3986 18.8307 -3.5119 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7411 8.3628 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0361 6.4016 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2855 5.4696 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4173 9.2552 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 10.3844 16.8298 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8243 15.8407 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7010 14.2696 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 13.4010 16.5932 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9661 15.5180 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9659 14.3813 -1.7103 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5698 16.6850 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9975 14.3649 1.5283 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8719 3.1005 -1.3283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1829 1.1422 -1.2441 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2754 0.6983 -0.2490 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9349 2.6521 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5689 3.5866 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5741 0.2561 -1.4959 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7584 14.3320 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4780 17.1177 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7533 22.4021 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8632 23.9974 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7126 22.4271 -2.7462 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0012 8.7352 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0236 8.7236 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7536 6.0409 -1.1882 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7761 6.0292 1.1191 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5680 5.8305 1.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5456 5.8420 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4839 8.5896 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4828 18.0835 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4994 17.8468 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9436 15.2027 -2.8596 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1305 13.5813 -1.7256 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8235 13.5499 -1.7033 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5700 17.4948 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7344 15.8851 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5475 17.5065 -1.2442 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8551 13.5335 1.5352 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1621 13.5648 1.5129 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9976 15.1747 2.6862 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0810 3.7821 -1.0636 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4050 3.4491 -2.6155 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0930 0.7649 -2.2570 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7155 0.8031 0.0200 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7234 0.3462 1.0440 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0826 0.0000 -0.5422 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4209 2.9934 -1.5943 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0064 0.6752 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 35 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 29 1 0 0 0 0 27 30 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 35 1 0 0 0 0 31 32 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 32 36 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 36 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 M END > (344) 343 > (344) C25H31Cl2N7O2 > (344) 532.4716 > (344) FGFR-P343 > (344) 6-arylpyrido[2,3-d]pyrimidine deriv. 43 > (344) FGFR-1 Tyrosine Kinase > (344) 72 > (344) BINDDB > (344) <2007 > (344) P > (344) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 45 csChFnd70/04170815452D 72 75 0 0 0 0 0 0 0 0999 V2000 7.0795 14.2824 -1.3774 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0986 11.4682 -1.2624 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8012 12.6049 -1.2080 N 0 0 0 0 0 0 0 0 0 0 0 0 9.7293 11.9364 -1.4866 N 0 0 0 0 0 0 0 0 0 0 0 0 8.7906 14.8592 -1.6199 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1435 13.6117 -1.6715 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1928 16.6253 -1.8114 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1922 15.7647 -2.0829 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9162 17.0760 -2.0453 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7827 14.1165 -1.9004 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4159 18.9205 -2.2551 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2928 21.6378 -1.0094 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3489 22.3669 -2.6471 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8285 19.9200 -0.8053 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4820 19.6615 -3.9037 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9484 21.3807 -4.0904 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7581 19.0073 1.2510 Cl 0 0 0 0 0 0 0 0 0 0 0 0 10.9805 18.4255 -5.7169 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.9260 9.1635 -0.8241 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8691 7.1877 -0.6548 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9925 6.6003 -0.3920 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7228 9.7261 -1.0758 N 0 0 3 0 0 0 0 0 0 0 0 0 2.1498 2.0796 -0.3157 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8961 2.1471 1.3942 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8125 4.1294 1.3616 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9378 4.7033 -0.2294 N 0 0 3 0 0 0 0 0 0 0 0 0 3.0533 1.4119 1.3211 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1457 4.0638 -0.2987 C 0 0 1 0 0 0 0 0 0 0 0 0 1.2670 4.7372 -1.9450 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9162 16.2216 -2.3176 N 0 0 3 0 0 0 0 0 0 0 0 0 15.1505 14.9850 -2.3565 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7531 13.4692 -2.1863 O 0 0 0 0 0 0 0 0 0 0 0 0 16.8252 15.4290 -2.5845 N 0 0 3 0 0 0 0 0 0 0 0 0 17.7971 12.8283 -4.1168 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1669 14.0849 -2.6269 C 0 0 0 0 0 0 0 0 0 0 0 0 19.9411 14.9297 -2.8992 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1635 13.0927 -0.9088 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0160 15.1925 -1.3368 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1895 17.6016 -1.7777 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6131 22.4130 0.1119 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7128 23.7107 -2.7998 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9999 21.9560 -5.3660 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1473 9.5639 -1.9337 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4083 9.7523 0.3518 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3867 6.5989 -1.8307 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6478 6.7874 0.4547 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4747 7.1891 0.7840 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2137 7.0007 -1.5014 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6489 8.8755 -1.1115 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8425 1.6190 -1.4583 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8188 1.6053 -0.3469 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6321 1.6875 0.2785 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5273 1.7209 2.5849 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0917 4.5888 2.4872 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1233 4.6568 1.3948 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3324 1.8301 2.4626 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1091 0.0000 1.2873 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4373 4.5236 0.8345 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0674 4.4257 -3.0675 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.1270 -2.0860 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1073 6.1386 -1.8545 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2334 17.4311 -2.4535 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1424 16.6385 -2.7204 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7995 13.5351 -5.3407 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7952 11.8282 -4.1484 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5331 12.2264 -3.9229 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2044 15.8249 -1.8376 H 0 0 0 0 0 0 0 0 0 0 0 0 20.9392 13.9296 -2.9307 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9434 15.6365 -4.1231 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8995 12.4909 -0.7148 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1616 12.0927 -0.9405 H 0 0 0 0 0 0 0 0 0 0 0 0 18.4268 13.9879 0.1526 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 38 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 30 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 26 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 49 1 0 0 0 0 23 28 1 0 0 0 0 23 27 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 24 52 1 0 0 0 0 24 53 1 0 0 0 0 25 26 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 28 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 31 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 35 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 35 36 1 0 0 0 0 35 37 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 37 72 1 0 0 0 0 M END > (345) 344 > (345) C27H35Cl2N7O > (345) 544.5258 > (345) FGFR-P344 > (345) 6-arylpyrido[2,3-d]pyrimidine deriv. 45 > (345) FGFR-1 Tyrosine Kinase > (345) 60 > (345) BINDDB > (345) <2007 > (345) P > (345) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 46 csChFnd70/04170815452D 55 58 0 0 0 0 0 0 0 0999 V2000 3.9887 15.9810 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4967 13.3939 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0119 14.2725 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0253 14.1623 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5771 16.8715 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1364 15.8940 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6599 18.6912 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7785 18.4051 -0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2823 19.4603 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6671 16.7001 -0.0293 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4469 21.3751 0.0056 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6929 24.0564 1.5709 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7539 24.9531 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5397 22.2723 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5172 22.2864 -1.5547 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6705 24.0704 -1.5390 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4619 21.1492 3.5214 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4128 21.1807 -3.5120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7589 10.7107 -0.0141 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0542 8.7495 -0.0275 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3036 7.8171 -0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4352 11.6033 -0.0253 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2482 3.4830 1.1139 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2899 3.0441 0.1650 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9598 4.9966 0.2908 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5871 5.9342 -0.0285 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9182 5.4355 1.2398 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3954 19.1777 -0.0337 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6209 2.5455 1.4333 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9044 0.6624 1.4205 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7760 16.6805 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4942 19.4664 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7649 24.7525 2.7835 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8733 26.3481 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7251 24.7774 -2.7461 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0190 11.0834 -1.1588 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0411 11.0711 1.1484 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7719 8.3891 -1.1900 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7940 8.3768 1.1173 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5858 8.1775 1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5638 8.1900 -1.1605 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5019 10.9377 -0.0390 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7280 3.1682 -0.1772 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2080 3.1039 2.0793 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0927 2.3451 0.4384 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7361 2.7244 -1.1370 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3756 -0.6745 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4799 5.3113 1.5820 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4720 5.7552 2.5419 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1154 6.1346 0.9663 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4321 18.4661 -0.0474 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4933 20.4313 -0.0283 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8311 0.3188 2.4304 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6795 0.0000 1.6600 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4131 0.2712 0.1617 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 31 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 32 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 33 1 0 0 0 0 13 16 1 0 0 0 0 13 34 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 35 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 20 21 1 0 0 0 0 20 38 1 0 0 0 0 20 39 1 0 0 0 0 21 26 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 22 42 1 0 0 0 0 23 27 1 0 0 0 0 23 29 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 29 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 M END > (346) 345 > (346) C21H25Cl2N7 > (346) 446.3814 > (346) FGFR-P345 > (346) 6-arylpyrido[2,3-d]pyrimidine deriv. 46 > (346) FGFR-1 Tyrosine Kinase > (346) 450 > (346) BINDDB > (346) <2007 > (346) P > (346) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 47 csChFnd70/04170815452D 71 74 0 0 0 0 0 0 0 0999 V2000 3.9531 15.8340 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4474 13.2707 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9761 14.1413 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9621 14.0317 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5275 16.7163 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0725 15.7477 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6103 18.5188 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6999 18.2347 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2191 19.2803 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5892 16.5461 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3834 21.1774 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6287 23.8341 1.5564 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6903 24.7227 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4758 22.0664 1.5583 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4535 22.0803 -1.5406 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6066 23.8480 -1.5251 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3981 20.9537 3.4892 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3495 20.9849 -3.4800 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7253 10.6122 -0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0176 8.6687 -0.0254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2828 7.7452 -0.0131 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3862 11.4964 -0.0245 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2096 3.4509 1.1074 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2780 3.0157 0.1678 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9510 4.9505 0.2918 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5637 5.8792 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8827 5.3855 1.2314 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3083 19.0023 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7351 18.0221 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6129 16.4653 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2975 18.7679 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8481 16.5759 -1.6948 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8484 17.7024 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4374 18.8588 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8795 16.5597 1.5144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5970 2.5220 1.4244 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8779 0.6561 1.4123 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7514 16.5271 0.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4555 19.2876 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7010 24.5239 2.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8100 26.1047 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6606 24.5487 -2.7213 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9920 10.9812 -1.1469 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0143 10.9697 1.1392 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7286 8.3113 -1.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7508 8.2997 1.1089 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5718 8.1028 1.1388 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5496 8.1142 -1.1473 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4431 10.8368 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6848 3.1385 -0.1721 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1607 3.0754 2.0638 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0917 2.3233 0.4392 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7197 2.6986 -1.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3259 -0.6646 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4759 5.2628 1.5713 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4410 5.7027 2.5216 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0690 6.0779 0.9600 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4057 20.2445 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3950 20.0100 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8260 17.3899 -2.8337 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0021 15.7832 -1.7099 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7161 15.7522 -1.6878 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4377 19.6612 1.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5914 18.0661 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4153 19.6728 -1.2329 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7475 15.7359 1.5212 H 0 0 0 0 0 0 0 0 0 0 0 0 16.0335 15.7669 1.4991 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8796 17.3621 2.6618 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7962 0.3159 2.4129 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6639 0.0000 1.6501 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3817 0.2681 0.1649 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 38 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 22 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 22 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 20 21 1 0 0 0 0 20 45 1 0 0 0 0 20 46 1 0 0 0 0 21 26 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 49 1 0 0 0 0 23 27 1 0 0 0 0 23 36 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 36 1 0 0 0 0 24 25 1 0 0 0 0 24 52 1 0 0 0 0 24 53 1 0 0 0 0 25 26 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 27 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 33 1 0 0 0 0 31 59 1 0 0 0 0 32 33 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 35 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 36 37 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 M END > (347) 346 > (347) C26H34Cl2N8O > (347) 545.5136 > (347) FGFR-P346 > (347) 6-arylpyrido[2,3-d]pyrimidine deriv. 47 > (347) FGFR-1 Tyrosine Kinase > (347) 51 > (347) BINDDB > (347) <2007 > (347) P > (347) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 49 csChFnd70/04170815452D 74 77 0 0 0 0 0 0 0 0999 V2000 8.0707 15.7201 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5788 13.1330 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0940 14.0117 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 11.1075 13.9011 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6597 16.6106 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2190 15.6330 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7432 18.4297 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8615 18.1430 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3669 19.1982 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7497 16.4388 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5327 21.1129 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7803 23.7942 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8425 24.6910 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6260 22.0103 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6035 22.0243 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7580 23.8082 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5476 20.8871 3.5214 Cl 0 0 0 0 0 0 0 0 0 0 0 0 11.4985 20.9186 -3.5122 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8408 10.4500 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1358 8.4886 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5171 11.3424 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3850 7.5565 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6800 5.5951 -0.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2917 4.1386 1.5440 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4331 1.9687 -0.4143 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2166 2.8348 -0.3345 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0751 5.0046 1.6238 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9992 4.7002 -0.0141 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5092 2.2732 1.2236 N 0 0 0 0 0 0 0 0 0 0 0 0 0.8281 1.3783 1.2354 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4846 18.9177 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 15.9246 17.9285 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 15.8014 16.3572 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 17.5015 18.6811 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 19.0668 17.6057 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0665 16.4689 -1.7104 C 0 0 0 0 0 0 0 0 0 0 0 0 20.6705 18.7729 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0981 16.4525 1.5284 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8579 16.4196 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5778 19.2056 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8532 24.4903 2.7834 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9632 26.0858 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8125 24.5154 -2.7464 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1007 10.8224 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1232 10.8108 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8534 8.1278 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8758 8.1161 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5838 10.6767 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6674 7.9174 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6450 7.9289 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3976 5.2343 -1.1886 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4201 5.2227 1.1188 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6189 4.3309 2.7716 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5357 4.7119 0.4968 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6902 2.5174 -1.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5925 0.5790 -0.6145 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9725 2.2615 0.7127 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8894 2.6426 -1.5621 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9158 6.3943 1.8240 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8182 4.4561 2.6933 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9180 0.2257 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0266 0.0000 0.9952 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2105 1.5528 2.4943 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5830 20.1714 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5999 19.9347 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0442 17.2905 -2.8599 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2312 15.6689 -1.7257 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9240 15.6375 -1.7034 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6707 19.5827 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8352 17.9729 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6482 19.5944 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9556 15.6210 1.5353 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2628 15.6524 1.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0983 17.2625 2.6864 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 31 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 22 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 48 1 0 0 0 0 22 23 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 29 1 0 0 0 0 24 27 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 28 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 1 0 0 0 0 31 64 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 34 35 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 37 1 0 0 0 0 35 38 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 38 74 1 0 0 0 0 M END > (348) 347 > (348) C27H36Cl2N8O > (348) 559.5404 > (348) FGFR-P347 > (348) 6-arylpyrido[2,3-d]pyrimidine deriv. 49 > (348) FGFR-1 Tyrosine Kinase > (348) 35 > (348) BINDDB > (348) <2007 > (348) P > (348) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 50 csChFnd70/04170815452D 59 62 0 0 0 0 0 0 0 0999 V2000 3.9765 15.9625 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4846 13.3756 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 14.2543 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0133 14.1437 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5655 16.8530 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1247 15.8755 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6490 18.6721 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7671 18.3853 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2727 19.4406 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6554 16.6813 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4385 21.3553 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6861 24.0364 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7482 24.9332 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5318 22.2525 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5092 22.2665 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6638 24.0504 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4534 21.1295 3.5212 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4042 21.1610 -3.5120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7465 10.6926 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0416 8.7313 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4229 11.5851 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2909 7.7992 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3902 19.1600 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8302 18.1709 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7069 16.5997 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 13.4070 18.9235 -0.0644 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8805 5.4308 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2126 3.4772 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0283 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9818 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5743 5.9161 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8624 0.6599 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6621 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4835 19.4480 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7589 24.7325 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8690 26.3280 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7182 24.7575 -2.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0066 11.0651 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0534 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 8.3706 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.3589 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4895 10.9194 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1602 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1717 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4886 20.4138 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5054 20.1770 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4434 18.2115 -0.0780 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0828 6.1269 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4094 5.7639 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1534 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7171 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6951 1.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4364 5.3101 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3509 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3954 0.2556 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7694 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 22 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 43 1 0 0 0 0 22 31 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 46 1 0 0 0 0 24 25 2 0 0 0 0 24 26 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 32 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 32 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 30 31 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (349) 348 > (349) C22H26Cl2N8O > (349) 489.4064 > (349) FGFR-P348 > (349) 6-arylpyrido[2,3-d]pyrimidine deriv. 50 > (349) FGFR-1 Tyrosine Kinase > (349) 140 > (349) BINDDB > (349) <2007 > (349) P > (349) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 51 csChFnd70/04170815452D 65 68 0 0 0 0 0 0 0 0999 V2000 3.9765 15.9625 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4846 13.3756 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 14.2543 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0133 14.1437 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5655 16.8530 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1247 15.8755 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6490 18.6721 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7671 18.3853 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2727 19.4406 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6554 16.6813 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4385 21.3553 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6861 24.0364 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7482 24.9332 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5318 22.2525 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5092 22.2665 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6638 24.0504 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4534 21.1295 3.5212 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4042 21.1610 -3.5120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7465 10.6926 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0416 8.7313 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4229 11.5851 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2909 7.7992 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3902 19.1600 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8302 18.1709 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7069 16.5997 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8805 5.4308 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2126 3.4772 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0283 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9818 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5743 5.9161 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8624 0.6599 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4070 18.9235 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9722 17.8481 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5759 19.0152 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6621 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4835 19.4480 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7589 24.7325 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8690 26.3280 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7182 24.7575 -2.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0066 11.0651 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0534 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 8.3706 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.3589 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4895 10.9194 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1602 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1717 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4886 20.4138 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0828 6.1269 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4094 5.7639 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1534 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7171 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6951 1.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4364 5.3101 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3509 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3954 0.2556 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7694 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5054 20.1770 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9946 17.0266 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9721 17.0383 -1.2430 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5536 19.8367 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5761 19.8251 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7405 18.2152 -0.1102 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 36 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 38 1 0 0 0 0 13 16 1 0 0 0 0 13 39 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 40 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 19 42 1 0 0 0 0 20 22 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 45 1 0 0 0 0 22 30 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 48 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 31 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 29 30 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 31 32 1 0 0 0 0 32 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 34 1 0 0 0 0 33 60 1 0 0 0 0 34 35 1 0 0 0 0 34 61 1 0 0 0 0 34 62 1 0 0 0 0 35 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 M END > (350) 349 > (350) C24H30Cl2N8O > (350) 517.46 > (350) FGFR-P349 > (350) 6-arylpyrido[2,3-d]pyrimidine deriv. 51 > (350) FGFR-1 Tyrosine Kinase > (350) 53 > (350) BINDDB > (350) <2007 > (350) P > (350) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 52 csChFnd70/04170815452D 66 69 0 0 0 0 0 0 0 0999 V2000 3.9901 16.0170 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5033 13.4212 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0134 14.3028 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0372 14.1919 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5845 16.9105 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1491 15.9296 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6683 18.7357 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7970 18.4480 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2975 19.5069 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6849 16.7382 -0.0295 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4638 21.4281 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7123 24.1184 1.5761 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7746 25.0182 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5575 22.3284 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5348 22.3424 -1.5601 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6899 24.1324 -1.5444 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4788 21.2015 3.5332 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4295 21.2331 -3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7593 10.7291 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0554 8.7611 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4413 11.6246 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2987 7.8258 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4257 19.2254 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8706 18.2329 -0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7469 16.6564 -0.0597 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8937 5.4493 -1.3290 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2270 3.4890 -1.2295 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2772 3.0387 -0.2248 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9441 4.9988 -0.3243 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5831 5.9363 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5881 2.5516 -1.5281 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8722 0.6620 -1.5404 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4527 18.9879 -0.0646 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0233 17.9090 -0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6082 19.0625 -0.0949 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8070 18.8732 1.1013 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7733 16.7189 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4988 19.5143 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7854 24.8168 2.7929 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8958 26.4177 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7445 24.8419 -2.7557 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0169 11.1028 -1.1615 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0394 11.0911 1.1537 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7754 8.3991 -1.1923 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7979 8.3873 1.1230 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5116 10.9566 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5787 8.1879 1.1533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5562 8.1995 -1.1619 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5244 20.4833 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1002 6.1478 -1.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4210 5.7836 -2.6232 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1709 3.1187 -2.2204 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7332 3.1597 0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7500 2.7043 1.0694 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3401 -0.4832 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4378 5.3282 -1.6070 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3692 0.6667 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4070 0.2565 -0.2915 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6386 0.0000 -1.7638 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7822 0.3278 -2.5750 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5514 20.2458 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0457 17.0847 1.0680 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0231 17.0964 -1.2472 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7560 20.0450 -1.0881 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9428 19.6999 1.0944 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6593 17.8907 2.0943 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 22 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 46 1 0 0 0 0 22 30 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 31 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 31 32 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 35 36 2 0 0 0 0 35 64 1 0 0 0 0 36 65 1 0 0 0 0 36 66 1 0 0 0 0 M END > (351) 350 > (351) C25H30Cl2N8O > (351) 529.471 > (351) FGFR-P350 > (351) 6-arylpyrido[2,3-d]pyrimidine deriv. 52 > (351) FGFR-1 Tyrosine Kinase > (351) 35 > (351) BINDDB > (351) <2007 > (351) P > (351) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 53 csChFnd70/04170815452D 68 71 0 0 0 0 0 0 0 0999 V2000 3.9901 16.0170 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5033 13.4212 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0134 14.3028 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0372 14.1919 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5845 16.9105 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1491 15.9296 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6683 18.7357 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7970 18.4480 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2975 19.5069 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6849 16.7382 -0.0295 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4638 21.4281 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7123 24.1184 1.5761 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7746 25.0182 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5575 22.3284 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5348 22.3424 -1.5601 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6899 24.1324 -1.5444 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4788 21.2015 3.5332 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4295 21.2331 -3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7593 10.7291 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0554 8.7611 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4413 11.6246 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2987 7.8258 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4257 19.2254 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8706 18.2329 -0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7469 16.6564 -0.0597 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8937 5.4493 -1.3290 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2270 3.4890 -1.2295 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2772 3.0387 -0.2248 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9441 4.9988 -0.3243 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5831 5.9363 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5881 2.5516 -1.5281 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8722 0.6620 -1.5404 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4527 18.9879 -0.0646 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0233 17.9090 -0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5253 18.9392 -0.8878 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4957 17.3892 1.7767 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7733 16.7189 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4988 19.5143 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7854 24.8168 2.7929 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8958 26.4177 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7445 24.8419 -2.7557 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0169 11.1028 -1.1615 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0394 11.0911 1.1537 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7754 8.3991 -1.1923 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7979 8.3873 1.1230 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5116 10.9566 -0.0386 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5787 8.1879 1.1533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5562 8.1995 -1.1619 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5244 20.4833 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1002 6.1478 -1.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4210 5.7836 -2.6232 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1709 3.1187 -2.2204 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7332 3.1597 0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7500 2.7043 1.0694 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3401 -0.4832 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4378 5.3282 -1.6070 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3692 0.6667 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4070 0.2565 -0.2915 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6386 0.0000 -1.7638 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7822 0.3278 -2.5750 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5514 20.2458 -0.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7854 16.7427 -0.8557 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7631 20.1055 -0.1175 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6939 18.1364 -0.9033 H 0 0 0 0 0 0 0 0 0 0 0 0 16.1886 19.3096 -2.2144 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4256 16.6553 2.3485 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6643 16.5865 1.7612 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7336 18.5555 2.5471 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 37 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 38 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 39 1 0 0 0 0 13 16 1 0 0 0 0 13 40 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 41 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 42 1 0 0 0 0 19 43 1 0 0 0 0 20 22 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 46 1 0 0 0 0 22 30 1 0 0 0 0 22 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 31 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 31 32 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 36 1 0 0 0 0 34 62 1 0 0 0 0 35 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 M END > (352) 351 > (352) C25H32Cl2N8O > (352) 531.4868 > (352) FGFR-P351 > (352) 6-arylpyrido[2,3-d]pyrimidine deriv. 53 > (352) FGFR-1 Tyrosine Kinase > (352) 34 > (352) BINDDB > (352) <2007 > (352) P > (352) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 54 csChFnd70/04170815452D 83 86 0 0 0 0 0 0 0 0999 V2000 3.9953 16.0378 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5104 13.4385 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0186 14.3214 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0462 14.2103 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5917 16.9324 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1582 15.9502 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6755 18.7600 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8083 18.4719 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3068 19.5321 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6960 16.7598 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4734 21.4558 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7222 24.1495 1.5782 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7846 25.0505 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5672 22.3572 1.5801 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5445 22.3713 -1.5622 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6998 24.1636 -1.5464 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4884 21.2289 3.5378 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4390 21.2606 -3.5286 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7642 10.7430 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0606 8.7724 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4484 11.6396 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3017 7.8359 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4391 19.2502 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8859 18.2565 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7621 16.6779 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8987 5.4563 -1.3307 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2324 3.4935 -1.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2789 3.0426 -0.2251 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9453 5.0053 -0.3247 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5864 5.9440 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5914 2.5549 -1.5301 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8759 0.6629 -1.5423 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4701 19.0125 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0427 17.9322 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6539 19.1048 -0.0952 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2965 17.9764 -0.1170 C 0 0 0 0 0 0 0 0 0 0 0 0 19.9077 19.1490 -0.1267 C 0 0 0 0 0 0 0 0 0 0 0 0 21.5501 18.0207 -0.1485 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1614 19.1933 -0.1582 C 0 0 0 0 0 0 0 0 0 0 0 0 24.8037 18.0650 -0.1800 C 0 0 0 0 0 0 0 0 0 0 0 0 26.4150 19.2375 -0.1898 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7768 16.7406 0.0218 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5046 19.5395 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7954 24.8489 2.7965 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9060 26.4518 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7545 24.8741 -2.7592 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0208 11.1172 -1.1630 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0433 11.1054 1.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.4099 -1.1938 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8041 8.3982 1.1244 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5200 10.9708 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5808 8.1985 1.1547 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5582 8.2101 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5380 20.5098 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1068 6.1557 -1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4254 5.7911 -2.6265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1776 3.1227 -2.2233 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7393 3.1638 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7523 2.7078 1.0707 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0709 2.3431 -0.4839 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4384 5.3351 -1.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3761 0.6676 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4114 0.2568 -0.2919 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6407 0.0000 -1.7661 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3282 -2.5783 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5690 20.2720 -0.0593 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0652 17.1068 1.0693 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0426 17.1185 -1.2488 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6315 19.9301 -1.2501 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6542 19.9184 1.0681 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3189 17.1511 1.0379 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2962 17.1628 -1.2803 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8853 19.9744 -1.2816 H 0 0 0 0 0 0 0 0 0 0 0 0 19.9078 19.9627 1.0366 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5725 17.1954 1.0064 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5500 17.2071 -1.3118 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1389 20.0187 -1.3131 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1616 20.0070 1.0051 H 0 0 0 0 0 0 0 0 0 0 0 0 24.8261 17.2397 0.9749 H 0 0 0 0 0 0 0 0 0 0 0 0 24.8036 17.2514 -1.3433 H 0 0 0 0 0 0 0 0 0 0 0 0 27.5851 18.4337 -0.2053 H 0 0 0 0 0 0 0 0 0 0 0 0 26.3926 20.0630 -1.3446 H 0 0 0 0 0 0 0 0 0 0 0 0 26.4152 20.0512 0.9736 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 42 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 35 36 1 0 0 0 0 35 69 1 0 0 0 0 35 70 1 0 0 0 0 36 37 1 0 0 0 0 36 71 1 0 0 0 0 36 72 1 0 0 0 0 37 38 1 0 0 0 0 37 73 1 0 0 0 0 37 74 1 0 0 0 0 38 39 1 0 0 0 0 38 75 1 0 0 0 0 38 76 1 0 0 0 0 39 40 1 0 0 0 0 39 77 1 0 0 0 0 39 78 1 0 0 0 0 40 41 1 0 0 0 0 40 79 1 0 0 0 0 40 80 1 0 0 0 0 41 81 1 0 0 0 0 41 82 1 0 0 0 0 41 83 1 0 0 0 0 M END > (353) 352 > (353) C30H42Cl2N8O > (353) 601.6208 > (353) FGFR-P352 > (353) 6-arylpyrido[2,3-d]pyrimidine deriv. 54 > (353) FGFR-1 Tyrosine Kinase > (353) 420 > (353) BINDDB > (353) <2007 > (353) P > (353) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 55 csChFnd70/04170815452D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9947 16.0355 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5096 13.4367 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0180 14.3193 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0453 14.2082 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5909 16.9300 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1573 15.9479 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6748 18.7573 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8071 18.4693 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3058 19.5292 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6948 16.7574 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4724 21.4527 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7211 24.1460 1.5780 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7835 25.0469 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5662 22.3540 1.5799 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5435 22.3680 -1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6987 24.1601 -1.5462 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4874 21.2258 3.5373 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4380 21.2575 -3.5281 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7637 10.7415 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0601 8.7712 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4476 11.6380 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3014 7.8348 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4377 19.2474 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8842 18.2539 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7604 16.6755 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8982 5.4556 -1.3305 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2318 3.4931 -1.2309 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2787 3.0422 -0.2250 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9452 5.0046 -0.3247 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5861 5.9432 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5910 2.5545 -1.5299 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8755 0.6629 -1.5421 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4682 19.0097 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0405 17.9296 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.6273 19.0844 -0.0951 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3356 19.6279 -1.6583 C 0 0 0 0 0 0 0 0 0 0 0 0 18.7911 20.6872 -1.6672 C 0 0 0 0 0 0 0 0 0 0 0 0 19.5381 21.2033 -0.1128 C 0 0 0 0 0 0 0 0 0 0 0 0 18.8292 20.6609 1.4505 C 0 0 0 0 0 0 0 0 0 0 0 0 17.3704 19.6061 1.4595 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7764 16.7382 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5040 19.5366 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7943 24.8453 2.7961 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9049 26.4480 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7534 24.8705 -2.7589 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0203 11.1156 -1.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0429 11.1039 1.1550 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7809 8.4087 -1.1937 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8034 8.3970 1.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5191 10.9693 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5806 8.1974 1.1546 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5580 8.2090 -1.1632 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5365 20.5069 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1061 6.1549 -1.0718 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4250 5.7903 -2.6262 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1769 3.1223 -2.2230 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7387 3.1633 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7521 2.7074 1.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3428 -0.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4383 5.3343 -1.6088 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3754 0.6675 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4109 0.2568 -0.2918 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6405 0.0000 -1.7659 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7866 0.3282 -2.5780 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5670 20.2691 -0.0593 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0630 17.1044 1.0692 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0404 17.1161 -1.2486 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7520 19.2245 -2.8728 H 0 0 0 0 0 0 0 0 0 0 0 0 19.3449 21.1110 -2.8886 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6759 22.0301 -0.1197 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4131 21.0638 2.6650 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8136 19.1862 2.6808 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 41 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 35 40 1 0 0 0 0 35 36 2 0 0 0 0 36 37 1 0 0 0 0 36 68 1 0 0 0 0 37 38 2 0 0 0 0 37 69 1 0 0 0 0 38 39 1 0 0 0 0 38 70 1 0 0 0 0 39 40 2 0 0 0 0 39 71 1 0 0 0 0 40 72 1 0 0 0 0 M END > (354) 353 > (354) C29H32Cl2N8O > (354) 579.5308 > (354) FGFR-P353 > (354) 6-arylpyrido[2,3-d]pyrimidine deriv. 55 > (354) FGFR-1 Tyrosine Kinase > (354) 62 > (354) BINDDB > (354) <2007 > (354) P > (354) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 56 csChFnd70/04170815452D 75 79 0 0 0 0 0 0 0 0999 V2000 3.9953 16.0378 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5104 13.4385 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0186 14.3214 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0462 14.2103 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5917 16.9324 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1582 15.9502 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6755 18.7600 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8083 18.4719 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3068 19.5321 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6960 16.7598 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4734 21.4558 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7222 24.1495 1.5782 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7846 25.0505 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5672 22.3572 1.5801 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5445 22.3713 -1.5622 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6998 24.1636 -1.5464 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4884 21.2289 3.5378 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4390 21.2606 -3.5286 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7642 10.7430 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0606 8.7724 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4484 11.6396 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3017 7.8359 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4391 19.2502 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8859 18.2565 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7621 16.6779 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8987 5.4563 -1.3307 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2324 3.4935 -1.2311 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2789 3.0426 -0.2251 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9453 5.0053 -0.3247 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5864 5.9440 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5914 2.5549 -1.5301 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8759 0.6629 -1.5423 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4701 19.0125 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 15.0427 17.9322 -0.0854 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5466 18.9637 -0.8889 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1890 17.8354 -0.9107 C 0 0 0 0 0 0 0 0 0 0 0 0 18.6621 17.3149 0.9538 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1583 16.2834 1.7573 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5157 17.4117 1.7790 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7768 16.7406 0.0218 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5046 19.5395 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7954 24.8489 2.7965 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9060 26.4518 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7545 24.8741 -2.7592 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0208 11.1172 -1.1630 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0433 11.1054 1.1551 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.4099 -1.1938 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8041 8.3982 1.1244 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5200 10.9708 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5808 8.1985 1.1547 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5582 8.2101 -1.1633 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5380 20.5098 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1068 6.1557 -1.0719 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4254 5.7911 -2.6265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1776 3.1227 -2.2233 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7393 3.1638 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7523 2.7078 1.0707 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0709 2.3431 -0.4839 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4384 5.3351 -1.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3761 0.6676 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4114 0.2568 -0.2919 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6407 0.0000 -1.7661 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3282 -2.5783 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5690 20.2720 -0.0593 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8045 16.7644 -0.8567 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2095 19.3345 -2.2173 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7848 20.1315 -0.1176 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9508 16.6676 -1.6820 H 0 0 0 0 0 0 0 0 0 0 0 0 19.2604 18.5702 -1.4831 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8322 16.5111 0.9383 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9003 18.4827 1.7251 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9199 15.1156 0.9860 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4952 15.9126 3.0856 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7540 18.5795 2.5503 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4443 16.6769 2.3514 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 40 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 21 49 1 0 0 0 0 22 30 1 0 0 0 0 22 50 1 0 0 0 0 22 51 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 31 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 31 32 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 1 0 0 0 0 34 39 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 36 37 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 38 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 38 39 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 39 74 1 0 0 0 0 39 75 1 0 0 0 0 M END > (355) 354 > (355) C28H36Cl2N8O > (355) 571.5514 > (355) FGFR-P354 > (355) 6-arylpyrido[2,3-d]pyrimidine deriv. 56 > (355) FGFR-1 Tyrosine Kinase > (355) 29 > (355) BINDDB > (355) <2007 > (355) P > (355) TRAIN $$$$ Structure2 csChFnd70/04170815452D 83 89 0 0 0 0 0 0 0 0999 V2000 7.7713 4.3166 0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8003 2.1953 0.0028 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7616 5.0508 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7454 5.0194 -1.7042 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7931 1.5112 -1.7426 C 0 0 2 0 0 0 0 0 0 0 0 0 10.7545 4.3667 -1.7460 C 0 0 1 0 0 0 0 0 0 0 0 0 7.7384 4.3352 -3.4496 C 0 0 2 0 0 0 0 0 0 0 0 0 10.7833 2.2455 -1.7576 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7671 2.2139 -3.4613 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7286 5.0696 -3.4647 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0262 14.9514 4.6794 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5891 15.3116 1.9068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7454 16.0233 3.3860 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7594 13.5097 1.6374 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1649 13.0196 4.4683 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0731 12.3072 2.8735 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4344 11.7853 5.7860 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5547 9.2946 3.8472 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6356 9.9018 5.4644 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2289 10.4795 2.6316 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8921 8.5358 6.8087 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3996 6.6024 7.8794 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5030 5.9834 9.3207 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0840 7.8750 6.6224 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0005 7.9001 8.2606 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2997 6.6274 9.5085 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6967 8.6509 4.8148 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2561 8.7059 8.4982 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.1468 18.5169 0.8554 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0584 19.5174 -0.7783 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3147 16.5089 0.5984 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8832 21.6145 -0.5100 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7531 7.4076 3.5306 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6279 6.8048 1.9932 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2430 7.9147 0.8837 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5828 21.7720 -2.5005 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3980 22.7354 -4.2067 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7261 25.5379 -3.4231 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9109 24.5746 -1.7170 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7583 22.5751 -2.0785 N 0 0 0 0 0 0 0 0 0 0 0 0 11.5505 24.7347 -3.8452 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4257 25.6955 -5.4136 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8206 4.9717 1.6858 N 0 0 3 0 0 0 0 0 0 0 0 0 8.5312 1.6948 1.2272 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3824 1.6722 0.0136 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7411 6.5620 0.0078 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4926 4.5503 1.2238 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3275 4.4962 -1.6935 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7250 6.5306 -1.6959 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8136 0.0000 -1.7509 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1724 4.8899 -1.7568 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0073 4.8359 -4.6741 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5143 1.7449 -0.5333 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4908 1.7582 -3.0011 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4745 1.7265 -4.7047 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3492 1.6909 -3.4506 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7081 6.5808 -3.4564 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4359 4.5820 -4.7082 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3501 15.5442 5.8768 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7372 12.2889 7.0118 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.0894 7.7362 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9614 4.9883 10.3000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1564 6.1343 10.6335 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8341 18.9197 2.1397 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6853 18.8954 0.9258 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5198 19.1389 -0.8487 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3711 19.1146 -2.0627 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9349 16.0197 -0.4900 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4217 21.9930 -0.4394 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5702 22.0173 0.7744 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2624 6.5220 4.4159 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4309 20.2946 -2.7801 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5060 21.9701 -1.3204 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7688 22.1697 -4.4983 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4937 22.5055 -5.3957 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8028 25.3398 -4.6031 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8779 27.0153 -3.1435 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8151 24.8045 -0.5280 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5400 25.1403 -1.4252 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5932 25.4902 -6.6581 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5215 27.1727 -5.1096 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8120 25.1361 -5.6369 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3299 4.0861 2.5710 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 3 1 0 0 0 0 1 4 1 0 0 0 0 1 43 1 0 0 0 0 2 5 1 0 0 0 0 2 44 1 0 0 0 0 2 45 1 0 0 0 0 3 6 1 0 0 0 0 3 46 1 0 0 0 0 3 47 1 0 0 0 0 4 7 1 0 0 0 0 4 48 1 0 0 0 0 4 49 1 0 0 0 0 5 8 1 0 0 0 0 5 9 1 0 0 0 0 5 50 1 0 0 0 0 6 10 1 0 0 0 0 6 8 1 0 0 0 0 6 51 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 52 1 0 0 0 0 8 53 1 0 0 0 0 8 54 1 0 0 0 0 9 55 1 0 0 0 0 9 56 1 0 0 0 0 10 57 1 0 0 0 0 10 58 1 0 0 0 0 11 13 1 0 0 0 0 11 15 2 0 0 0 0 11 59 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 12 31 1 0 0 0 0 14 16 2 0 0 0 0 15 17 1 0 0 0 0 15 16 1 0 0 0 0 16 20 1 0 0 0 0 17 19 2 0 0 0 0 17 60 1 0 0 0 0 18 20 2 0 0 0 0 18 19 1 0 0 0 0 18 33 1 0 0 0 0 19 21 1 0 0 0 0 21 24 2 0 0 0 0 21 25 1 0 0 0 0 22 24 1 0 0 0 0 22 23 2 0 0 0 0 22 61 1 0 0 0 0 23 26 1 0 0 0 0 23 62 1 0 0 0 0 24 27 1 0 0 0 0 25 26 2 0 0 0 0 25 28 1 0 0 0 0 26 63 1 0 0 0 0 29 31 1 0 0 0 0 29 30 1 0 0 0 0 29 64 1 0 0 0 0 29 65 1 0 0 0 0 30 32 1 0 0 0 0 30 66 1 0 0 0 0 30 67 1 0 0 0 0 31 68 1 0 0 0 0 32 40 1 0 0 0 0 32 69 1 0 0 0 0 32 70 1 0 0 0 0 33 34 1 0 0 0 0 33 71 1 0 0 0 0 34 35 2 0 0 0 0 34 43 1 0 0 0 0 36 40 1 0 0 0 0 36 37 1 0 0 0 0 36 72 1 0 0 0 0 36 73 1 0 0 0 0 37 41 1 0 0 0 0 37 74 1 0 0 0 0 37 75 1 0 0 0 0 38 41 1 0 0 0 0 38 39 1 0 0 0 0 38 76 1 0 0 0 0 38 77 1 0 0 0 0 39 40 1 0 0 0 0 39 78 1 0 0 0 0 39 79 1 0 0 0 0 41 42 1 0 0 0 0 42 80 1 0 0 0 0 42 81 1 0 0 0 0 42 82 1 0 0 0 0 43 83 1 0 0 0 0 M END > (356) 355 > (356) C32H40Cl2N8O > (356) 623.627 > (356) FGFR-P355 > (356) 6-arylpyrido[2,3-d]pyrimidine deriv. 57 > (356) FGFR-1 Tyrosine Kinase > (356) 120 > (356) BINDDB > (356) <2007 > (356) P > (356) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 58 csChFnd70/04170815452D 82 85 0 0 0 0 0 0 0 0999 V2000 3.9764 15.9621 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4844 13.3753 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9996 14.2539 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0131 14.1433 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5653 16.8526 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1246 15.8750 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6488 18.6716 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7669 18.3849 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2725 19.4401 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6551 16.6808 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4383 21.3548 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6859 24.0357 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7480 24.9325 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5316 22.2519 1.5727 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5091 22.2659 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6636 24.0497 -1.5391 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4532 21.1289 3.5211 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4041 21.1604 -3.5119 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7464 10.6924 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0415 8.7311 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4227 11.5848 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2909 7.7990 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3899 19.1595 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8299 18.1704 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7066 16.5993 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8804 5.4306 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2125 3.4771 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0283 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9817 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5743 5.9160 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5792 2.5428 -1.5229 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8624 0.6598 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4066 18.9230 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9718 17.8477 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5754 19.0147 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1408 17.9394 -0.1155 N 0 0 3 0 0 0 0 0 0 0 0 0 19.7175 18.6921 -0.1270 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8408 20.2623 -0.1203 O 0 0 0 0 0 0 0 0 0 0 0 0 21.1560 17.7039 -0.1461 O 0 0 0 0 0 0 0 0 0 0 0 0 22.9602 19.7314 1.4662 C 0 0 0 0 0 0 0 0 0 0 0 0 24.2833 17.2749 -0.1788 C 0 0 0 0 0 0 0 0 0 0 0 0 22.8098 18.6024 -0.1576 C 0 0 0 0 0 0 0 0 0 0 0 0 22.9287 19.7478 -1.7726 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7637 16.6616 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4834 19.4475 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7587 24.7319 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8688 26.3273 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7180 24.7569 -2.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0066 11.0648 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0289 11.0532 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7590 8.3703 -1.1882 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7814 8.3587 1.1191 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4894 10.9191 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1599 1.1493 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5509 8.1715 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4883 20.4132 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0827 6.1268 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4093 5.7638 -2.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1532 3.1080 -2.2128 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7170 3.1488 0.0531 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6951 1.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3321 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4363 5.3100 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3508 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3953 0.2556 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7578 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7693 0.3267 -2.5661 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5050 20.1765 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9942 17.0262 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9717 17.0378 -1.2429 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5531 19.8362 -1.2442 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5757 19.8246 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0424 16.6859 -0.1208 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8755 18.9154 2.6164 H 0 0 0 0 0 0 0 0 0 0 0 0 24.2018 20.4060 1.4573 H 0 0 0 0 0 0 0 0 0 0 0 0 21.9106 20.6772 1.4811 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1761 16.4707 -1.3356 H 0 0 0 0 0 0 0 0 0 0 0 0 25.5248 17.9495 -0.1875 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1987 16.4590 0.9717 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8790 20.6935 -1.7576 H 0 0 0 0 0 0 0 0 0 0 0 0 24.1702 20.4223 -1.7813 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8215 18.9434 -2.9293 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 44 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 35 1 0 0 0 0 34 69 1 0 0 0 0 34 70 1 0 0 0 0 35 36 1 0 0 0 0 35 71 1 0 0 0 0 35 72 1 0 0 0 0 36 37 1 0 0 0 0 36 73 1 0 0 0 0 37 39 1 0 0 0 0 37 38 2 0 0 0 0 39 42 1 0 0 0 0 40 42 1 0 0 0 0 40 74 1 0 0 0 0 40 75 1 0 0 0 0 40 76 1 0 0 0 0 41 42 1 0 0 0 0 41 77 1 0 0 0 0 41 78 1 0 0 0 0 41 79 1 0 0 0 0 42 43 1 0 0 0 0 43 80 1 0 0 0 0 43 81 1 0 0 0 0 43 82 1 0 0 0 0 M END > (357) 356 > (357) C29H39Cl2N9O3 > (357) 632.5916 > (357) FGFR-P356 > (357) 6-arylpyrido[2,3-d]pyrimidine deriv. 58 > (357) FGFR-1 Tyrosine Kinase > (357) 67 > (357) BINDDB > (357) <2007 > (357) P > (357) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 59 csChFnd70/04170815452D 73 76 0 0 0 0 0 0 0 0999 V2000 3.9765 15.9625 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4846 13.3756 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9997 14.2543 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0133 14.1437 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5655 16.8530 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1247 15.8755 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6490 18.6721 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7671 18.3853 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2727 19.4406 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6554 16.6813 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4385 21.3553 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6861 24.0364 1.5708 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7482 24.9332 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5318 22.2525 1.5728 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5092 22.2665 -1.5549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6638 24.0504 -1.5392 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4534 21.1295 3.5212 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4042 21.1610 -3.5120 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7465 10.6926 -0.0128 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0416 8.7313 -0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4229 11.5851 -0.0248 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2909 7.7992 -0.0132 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3902 19.1600 -0.0337 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8302 18.1709 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7069 16.5997 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8805 5.4308 -1.3245 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2126 3.4772 -1.2253 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0283 -0.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9409 4.9818 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5743 5.9161 -0.0255 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5793 2.5430 -1.5230 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8624 0.6599 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4070 18.9235 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9722 17.8481 -0.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5759 19.0152 -0.0948 C 0 0 0 0 0 0 0 0 0 0 0 0 18.1455 17.9370 -0.1155 N 0 0 0 0 0 0 0 0 0 0 0 0 19.6963 18.9954 -0.4340 C 0 0 0 0 0 0 0 0 0 0 0 0 18.3152 16.9474 1.5026 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7639 16.6621 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4835 19.4480 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7589 24.7325 2.7833 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8690 26.3280 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7182 24.7575 -2.7463 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0066 11.0651 -1.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0291 11.0534 1.1497 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 8.3706 -1.1883 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7815 8.3589 1.1192 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4895 10.9194 -0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5734 8.1602 1.1494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 8.1717 -1.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4886 20.4138 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0828 6.1269 -1.0669 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4094 5.7639 -2.6143 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1534 3.1082 -2.2129 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7171 3.1490 0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7441 2.6951 1.0657 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0705 2.3322 -0.4816 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4364 5.3101 -1.6015 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3509 0.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3954 0.2556 -0.2905 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6330 0.0000 -1.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7694 0.3267 -2.5663 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5054 20.1770 -0.0590 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9946 17.0266 1.0643 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9721 17.0383 -1.2430 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5536 19.8367 -1.2443 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5761 19.8251 1.0632 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8246 19.9626 0.5880 H 0 0 0 0 0 0 0 0 0 0 0 0 20.8396 18.1649 -0.4428 H 0 0 0 0 0 0 0 0 0 0 0 0 19.5755 19.6438 -1.6837 H 0 0 0 0 0 0 0 0 0 0 0 0 17.1902 16.1071 1.6609 H 0 0 0 0 0 0 0 0 0 0 0 0 19.4876 16.1605 1.4527 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3934 17.8405 2.5949 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 39 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 21 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 40 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 41 1 0 0 0 0 13 16 1 0 0 0 0 13 42 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 43 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 20 22 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 48 1 0 0 0 0 22 30 1 0 0 0 0 22 49 1 0 0 0 0 22 50 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 31 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 56 1 0 0 0 0 28 57 1 0 0 0 0 29 30 1 0 0 0 0 29 58 1 0 0 0 0 29 59 1 0 0 0 0 31 32 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 36 37 1 0 0 0 0 36 38 1 0 0 0 0 37 68 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 38 71 1 0 0 0 0 38 72 1 0 0 0 0 38 73 1 0 0 0 0 M END > (358) 357 > (358) C26H35Cl2N9O > (358) 560.5282 > (358) FGFR-P357 > (358) 6-arylpyrido[2,3-d]pyrimidine deriv. 59 > (358) FGFR-1 Tyrosine Kinase > (358) 75 > (358) BINDDB > (358) <2007 > (358) P > (358) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 61 csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9778 15.9732 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4859 13.3862 0.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0009 14.2652 0.0183 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0142 14.1540 -0.0044 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5670 16.8637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1259 15.8861 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6505 18.6825 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7683 18.3955 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2741 19.4507 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6565 16.6916 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4400 21.3655 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6853 24.0577 1.5222 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7510 24.9428 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5302 22.2739 1.5367 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5139 22.2652 -1.5907 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6691 24.0490 -1.5877 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4471 21.1653 3.4931 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4119 21.1455 -3.5398 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7480 10.7037 0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0429 8.7424 0.0286 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4242 11.5960 0.0126 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2923 7.8107 0.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3914 19.1699 -0.0420 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8313 18.1805 -0.0516 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7078 16.6095 -0.0471 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8845 5.4332 -1.2475 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2162 3.4804 -1.1341 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2746 3.0388 -0.1361 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9429 4.9915 -0.2495 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5756 5.9276 0.0451 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5836 2.5442 -1.4288 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8667 0.6614 -1.4272 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4080 18.9327 -0.0661 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9017 17.9105 0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9460 16.2864 -0.7247 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4225 15.2807 -0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8556 15.8892 0.2804 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8155 17.5055 1.0543 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3457 18.5209 0.9353 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7651 16.6728 0.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4851 19.4583 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7557 24.7626 2.7296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8718 26.3376 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7259 24.7471 -2.7996 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0105 11.0682 -1.1218 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0280 11.0726 1.1854 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7628 8.3736 -1.1298 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7804 8.3780 1.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4907 10.9301 0.0058 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5724 8.1795 1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5549 8.1751 -1.1051 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4899 20.4233 -0.0456 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0862 6.1310 -0.9922 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4161 5.7574 -2.5403 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1591 3.1046 -2.1169 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7180 3.1611 0.1476 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7430 2.7145 1.1569 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0729 2.3408 -0.3913 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4411 5.3107 -1.5312 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3673 0.7334 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3969 0.2657 -0.1786 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6380 0.0000 -1.6480 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7758 0.3210 -2.4540 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5074 20.1829 -0.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8268 15.8101 -1.4179 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4577 14.0175 -1.2105 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0086 15.1001 0.3703 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9367 17.9770 1.7475 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3171 19.7854 1.5350 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 21 49 1 0 0 0 0 22 30 1 0 0 0 0 22 50 1 0 0 0 0 22 51 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 31 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 31 32 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 36 37 2 0 0 0 0 36 66 1 0 0 0 0 37 38 1 0 0 0 0 37 67 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (360) 359 > (360) C28H30Cl2N8O > (360) 565.504 > (360) FGFR-P359 > (360) 6-arylpyrido[2,3-d]pyrimidine deriv. 61 > (360) FGFR-1 Tyrosine Kinase > (360) 84 > (360) BINDDB > (360) <2007 > (360) P > (360) TRAIN $$$$ 1,6-naphthyridin 22 csChFnd70/04170815452D 74 76 0 0 0 0 0 0 0 0999 V2000 1.0110 15.6610 -0.3232 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7805 12.7379 -0.2826 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5440 13.1035 -0.2660 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7686 16.1635 -0.3083 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0792 14.8539 -0.2788 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2682 17.9280 -0.3223 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2601 16.9375 -0.2773 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0330 18.3098 -0.3065 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5905 14.0007 -0.3101 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7645 15.2938 -0.2653 N 0 0 0 0 0 0 0 0 0 0 0 0 5.6306 20.1488 -0.3207 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5255 23.0306 -1.5563 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9644 21.3132 -1.5465 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8539 20.7182 0.8963 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4095 22.4375 0.8794 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7492 23.5914 -0.3476 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8769 24.1669 -2.7517 O 0 0 0 0 0 0 0 0 0 0 0 0 5.5128 25.9175 -2.6871 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6021 22.9941 2.0662 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1166 24.7829 1.9737 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2356 11.0090 -0.2702 N 0 0 3 0 0 0 0 0 0 0 0 0 2.5262 9.6007 -0.2400 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5886 7.8393 -0.2319 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9366 6.3686 -0.2003 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9990 4.6073 -0.1921 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2933 3.1952 -0.1618 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2733 3.1974 1.4841 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9184 2.0868 1.2802 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4621 1.4957 -0.4638 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0160 1.3081 -2.3993 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0277 17.3297 -0.2623 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2152 16.0344 -0.2358 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7388 14.5223 -0.2250 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9310 16.4152 -0.2213 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2220 15.0072 -0.1925 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0580 15.7881 -0.1809 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.6416 -0.3397 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4927 12.0627 -0.2434 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3041 18.9544 -0.3449 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0121 20.8773 -2.4881 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3681 19.8207 1.8521 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1845 24.9309 -0.3580 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9205 25.9178 -2.8844 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8910 26.6854 -3.7089 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2120 26.4843 -1.4188 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0711 25.0546 2.9914 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6932 25.0448 0.7011 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9778 25.6135 2.1580 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0007 10.7351 -0.2817 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3538 9.6916 -1.3922 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3268 9.7168 0.9288 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7611 7.7484 0.9203 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7881 7.7234 -1.4008 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7642 6.4595 -1.3524 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7372 6.4847 0.9686 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1715 4.5163 0.9600 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1985 4.4912 -1.3609 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6394 4.5303 1.8158 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4624 2.6572 2.5193 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5530 0.7586 0.9299 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7385 2.6379 0.2584 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6358 2.0728 2.5074 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3540 0.4574 -0.0801 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2717 1.4068 0.3078 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0278 2.2665 -2.7530 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1854 1.5236 -3.1782 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5170 0.0000 -2.6459 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4078 18.5363 -0.2709 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3111 17.6217 -0.2299 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0356 14.2172 0.9746 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0607 14.1928 -1.3465 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0185 14.7405 -0.1595 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2442 16.5780 -1.3481 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2192 16.6024 0.9730 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 37 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 38 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 39 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 31 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 40 1 0 0 0 0 14 15 1 0 0 0 0 14 41 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 42 1 0 0 0 0 17 18 1 0 0 0 0 18 43 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 19 20 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 21 22 1 0 0 0 0 21 49 1 0 0 0 0 22 23 1 0 0 0 0 22 50 1 0 0 0 0 22 51 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 23 53 1 0 0 0 0 24 25 1 0 0 0 0 24 54 1 0 0 0 0 24 55 1 0 0 0 0 25 26 1 0 0 0 0 25 56 1 0 0 0 0 25 57 1 0 0 0 0 26 27 1 0 0 0 0 26 29 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 30 65 1 0 0 0 0 30 66 1 0 0 0 0 30 67 1 0 0 0 0 31 32 1 0 0 0 0 31 68 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 34 35 1 0 0 0 0 34 69 1 0 0 0 0 35 36 1 0 0 0 0 35 70 1 0 0 0 0 35 71 1 0 0 0 0 36 72 1 0 0 0 0 36 73 1 0 0 0 0 36 74 1 0 0 0 0 M END > (37) 35 > (37) C27H38N6O3 > (37) 494.6356 > (37) FGFR-P35 > (37) 1,6-naphthyridine 22 > (37) FGFR-1 Tyrosine Kinase > (37) 24 > (37) BINDDB > (37) <2007 > (37) P > (37) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 62 csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9776 15.9734 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4857 13.3866 0.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0007 14.2656 0.0183 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0139 14.1544 -0.0044 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5668 16.8640 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1256 15.8863 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6503 18.6827 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7681 18.3958 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2738 19.4510 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6561 16.6918 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4397 21.3657 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6851 24.0579 1.5222 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7508 24.9430 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5299 22.2741 1.5367 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5136 22.2654 -1.5906 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6687 24.0492 -1.5877 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4468 21.1655 3.4931 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4117 21.1455 -3.5397 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7477 10.7041 0.0283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0427 8.7430 0.0305 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4240 11.5963 0.0132 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2921 7.8111 0.0461 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3912 19.1701 -0.0414 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8309 18.1807 -0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7074 16.6098 -0.0459 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8840 5.4332 -1.2444 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2157 3.4805 -1.1305 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2745 3.0391 -0.1317 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9428 4.9918 -0.2458 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5753 5.9281 0.0482 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5831 2.5442 -1.4245 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8663 0.6614 -1.4224 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4076 18.9331 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9019 17.9103 0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9461 16.2864 -0.7224 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4221 15.2802 -0.6054 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8563 15.8889 0.2836 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8154 17.5065 1.0577 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3452 18.5210 0.9382 C 0 0 0 0 0 0 0 0 0 0 0 0 19.7096 14.6210 0.4283 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.7650 16.6730 0.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4850 19.4586 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7555 24.7627 2.7296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8716 26.3378 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7258 24.7472 -2.7997 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0101 11.0682 -1.1205 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0280 11.0734 1.1867 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7625 8.3737 -1.1280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7804 8.3788 1.1792 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4904 10.9304 0.0065 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5725 8.1804 1.2046 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5545 8.1751 -1.1026 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4897 20.4235 -0.0450 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0858 6.1312 -0.9896 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4154 5.7571 -2.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1585 3.1043 -2.1133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7178 3.1617 0.1513 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7431 2.7153 1.1613 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0727 2.3412 -0.3865 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4407 5.3107 -1.5274 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3680 0.7372 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3966 0.2663 -0.1738 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6374 0.0000 -1.6426 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7751 0.3207 -2.4491 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5070 20.1831 -0.1557 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8269 15.8105 -1.4158 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4569 14.0170 -1.2076 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9363 17.9785 1.7511 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3162 19.7859 1.5374 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (361) 360 > (361) C28H29Cl3N8O > (361) 599.9491 > (361) FGFR-P360 > (361) 6-arylpyrido[2,3-d]pyrimidine deriv. 62 > (361) FGFR-1 Tyrosine Kinase > (361) 120 > (361) BINDDB > (361) <2007 > (361) P > (361) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 63 csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 3.9776 15.9734 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4857 13.3866 0.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0007 14.2657 0.0183 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0139 14.1544 -0.0044 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5668 16.8640 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1256 15.8863 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6503 18.6827 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7681 18.3958 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2738 19.4510 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6561 16.6918 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4397 21.3657 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6851 24.0579 1.5222 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7508 24.9430 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5299 22.2741 1.5367 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5136 22.2654 -1.5906 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6687 24.0492 -1.5877 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4468 21.1655 3.4931 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4117 21.1455 -3.5397 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7477 10.7041 0.0284 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0427 8.7430 0.0305 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4240 11.5963 0.0132 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2921 7.8111 0.0463 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3912 19.1701 -0.0414 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8309 18.1807 -0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7074 16.6098 -0.0459 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8840 5.4332 -1.2444 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2157 3.4805 -1.1303 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2745 3.0391 -0.1317 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9428 4.9918 -0.2456 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5753 5.9281 0.0484 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5831 2.5442 -1.4243 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8663 0.6614 -1.4223 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4076 18.9331 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9018 17.9104 0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9460 16.2865 -0.7224 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4221 15.2803 -0.6052 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8560 15.8892 0.2835 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8153 17.5065 1.0576 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3451 18.5210 0.9382 C 0 0 0 0 0 0 0 0 0 0 0 0 19.8748 14.5080 0.4412 Br 0 0 0 0 0 0 0 0 0 0 0 0 2.7650 16.6730 0.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4851 19.4586 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7555 24.7627 2.7296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8716 26.3378 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7258 24.7472 -2.7997 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0101 11.0682 -1.1204 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0280 11.0734 1.1869 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7625 8.3737 -1.1280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7804 8.3788 1.1792 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4904 10.9304 0.0065 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5725 8.1804 1.2047 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5545 8.1751 -1.1025 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4897 20.4235 -0.0450 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0858 6.1312 -0.9896 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4154 5.7570 -2.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1585 3.1043 -2.1133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7178 3.1617 0.1513 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7431 2.7153 1.1613 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0727 2.3412 -0.3864 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4407 5.3107 -1.5274 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3680 0.7373 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3966 0.2663 -0.1737 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6374 0.0000 -1.6426 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7751 0.3207 -2.4491 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5070 20.1831 -0.1557 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8269 15.8104 -1.4159 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4571 14.0171 -1.2075 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9362 17.9784 1.7510 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3162 19.7860 1.5374 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (362) 361 > (362) C28H29BrCl2N8O > (362) 644.4001 > (362) FGFR-P361 > (362) 6-arylpyrido[2,3-d]pyrimidine deriv. 63 > (362) FGFR-1 Tyrosine Kinase > (362) 110 > (362) BINDDB > (362) <2007 > (362) P > (362) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 64 csChFnd70/04170815452D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9780 15.9741 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4862 13.3870 0.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0011 14.2661 0.0183 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0145 14.1548 -0.0044 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5674 16.8646 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1262 15.8870 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6508 18.6835 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7688 18.3965 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2744 19.4518 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6570 16.6925 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4404 21.3666 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6857 24.0589 1.5223 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7515 24.9443 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5305 22.2752 1.5368 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5142 22.2665 -1.5907 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6695 24.0503 -1.5878 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4475 21.1665 3.4934 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4123 21.1467 -3.5400 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7482 10.7043 0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0431 8.7429 0.0286 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4244 11.5966 0.0126 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2924 7.8112 0.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3920 19.1709 -0.0420 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8320 18.1815 -0.0516 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7084 16.6104 -0.0471 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8847 5.4336 -1.2476 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2164 3.4807 -1.1342 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2747 3.0389 -0.1361 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9429 4.9917 -0.2495 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5756 5.9280 0.0451 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5837 2.5444 -1.4288 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8669 0.6614 -1.4273 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4086 18.9338 -0.0661 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9025 17.9114 0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9468 16.2873 -0.7247 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4234 15.2816 -0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8565 15.8901 0.2804 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8164 17.5064 1.0543 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3467 18.5219 0.9353 C 0 0 0 0 0 0 0 0 0 0 0 0 19.4653 14.7890 0.4060 C 0 0 0 0 0 0 0 0 0 0 0 0 19.0022 13.0358 0.3732 F 0 0 0 0 0 0 0 0 0 0 0 0 20.5574 15.1521 -0.9957 F 0 0 0 0 0 0 0 0 0 0 0 0 20.3301 15.1569 1.9571 F 0 0 0 0 0 0 0 0 0 0 0 0 2.7653 16.6737 0.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4854 19.4593 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7562 24.7639 2.7298 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8723 26.3391 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7264 24.7485 -2.7998 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0107 11.0688 -1.1218 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0282 11.0732 1.1855 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7631 8.3741 -1.1298 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7807 8.3785 1.1775 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4911 10.9307 0.0058 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5725 8.1799 1.2022 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5550 8.1755 -1.1051 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4905 20.4245 -0.0456 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0865 6.1314 -0.9922 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4164 5.7578 -2.5405 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1593 3.1048 -2.1170 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7182 3.1614 0.1476 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7431 2.7146 1.1570 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0728 2.3410 -0.3913 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4411 5.3111 -1.5312 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3676 0.7334 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3972 0.2657 -0.1786 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6381 0.0000 -1.6480 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7761 0.3210 -2.4541 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5080 20.1840 -0.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8276 15.8110 -1.4180 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4587 14.0183 -1.2104 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9377 17.9780 1.7476 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3180 19.7865 1.5351 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 44 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 69 1 0 0 0 0 36 37 2 0 0 0 0 36 70 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 71 1 0 0 0 0 39 72 1 0 0 0 0 40 42 1 0 0 0 0 40 41 1 0 0 0 0 40 43 1 0 0 0 0 M END > (363) 362 > (363) C29H29Cl2F3N8O > (363) 633.5023 > (363) FGFR-P362 > (363) 6-arylpyrido[2,3-d]pyrimidine deriv. 64 > (363) FGFR-1 Tyrosine Kinase > (363) 610 > (363) BINDDB > (363) <2007 > (363) P > (363) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 65 csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 3.5759 14.3605 0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9316 12.0350 0.0080 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5967 12.8252 0.0167 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3056 12.7251 -0.0037 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0046 15.1611 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4060 14.2822 -0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0796 16.7961 -0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8827 16.5382 -0.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5392 17.4868 -0.0160 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7820 15.0063 -0.0199 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6884 19.2081 -0.0216 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9083 21.6285 1.3682 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9669 22.4243 -0.0322 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7695 20.0249 1.3814 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7548 20.0169 -1.4300 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8936 21.6206 -1.4274 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6956 19.0282 3.1403 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.6637 19.0101 -3.1824 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3693 9.6232 0.0259 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6344 7.8602 0.0279 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8762 10.4254 0.0122 N 0 0 3 0 0 0 0 0 0 0 0 0 2.0606 7.0224 0.0421 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3418 17.2343 -0.0378 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6362 16.3448 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5252 14.9325 -0.0422 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4918 4.8846 -1.1182 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7901 3.1291 -1.0156 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1457 2.7323 -0.1177 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8475 4.4878 -0.2204 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3153 5.3295 0.0439 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3223 2.2874 -1.2799 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5769 0.5947 -1.2780 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0536 17.0212 -0.0594 N 0 0 3 0 0 0 0 0 0 0 0 0 13.3970 16.1017 0.0453 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4363 14.6420 -0.6515 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7631 13.7363 -0.5468 C 0 0 0 0 0 0 0 0 0 0 0 0 14.6948 16.6508 0.8410 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0524 14.2819 0.2523 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0194 15.7407 0.9427 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7176 13.1405 0.3822 Cl 0 0 0 0 0 0 0 0 0 0 0 0 17.6398 16.4221 1.9441 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.4858 14.9894 0.0156 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0320 17.4936 0.0033 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9717 22.2622 2.4537 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0754 23.6783 -0.0364 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9447 22.2482 -2.5171 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7061 9.9506 -1.0070 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7222 9.9553 1.0672 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2815 7.5282 -1.0136 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2976 7.5329 1.0606 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8350 9.8268 0.0062 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4137 7.3544 1.0834 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3975 7.3496 -0.9908 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4303 18.3612 -0.0410 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5721 5.5121 -0.8891 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0705 5.1757 -2.2807 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6375 2.7909 -1.8992 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2413 2.8426 0.1366 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5670 2.4414 1.0447 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0654 2.1049 -0.3468 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3962 4.7743 -1.3725 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.8261 0.6633 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0537 0.2395 -0.1554 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4720 0.0000 -1.4759 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3939 0.2883 -2.2011 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1429 18.1450 -0.1416 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4299 14.2147 -1.2749 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7935 12.6010 -1.0889 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6691 17.7882 1.3793 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 37 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 38 2 0 0 0 0 36 68 1 0 0 0 0 37 39 2 0 0 0 0 37 69 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 39 41 1 0 0 0 0 M END > (364) 363 > (364) C28H28Cl4N8O > (364) 634.3942 > (364) FGFR-P363 > (364) 6-arylpyrido[2,3-d]pyrimidine deriv. 65 > (364) FGFR-1 Tyrosine Kinase > (364) 600 > (364) BINDDB > (364) <2007 > (364) P > (364) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 66 csChFnd70/04170815452D 72 76 0 0 0 0 0 0 0 0999 V2000 3.9774 15.9731 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4854 13.3863 0.0087 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0005 14.2653 0.0183 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0136 14.1541 -0.0044 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5665 16.8636 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1254 15.8860 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6500 18.6822 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7678 18.3954 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2735 19.4505 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6559 16.6914 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4395 21.3652 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6841 24.0573 1.5221 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7490 24.9426 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5297 22.2736 1.5366 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5134 22.2649 -1.5905 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6677 24.0486 -1.5876 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4475 21.1649 3.4930 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4121 21.1450 -3.5396 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7476 10.7038 0.0283 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0426 8.7426 0.0305 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4236 11.5961 0.0132 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2919 7.8109 0.0461 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3907 19.1696 -0.0420 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8306 18.1803 -0.0516 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7071 16.6094 -0.0471 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8839 5.4331 -1.2444 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2156 3.4804 -1.1304 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2743 3.0391 -0.1318 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9425 4.9917 -0.2458 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5752 5.9279 0.0482 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5830 2.5442 -1.4244 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8663 0.6614 -1.4223 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4072 18.9326 -0.0661 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9009 17.9103 0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9452 16.2863 -0.7247 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4215 15.2807 -0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3449 18.5205 0.9353 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8547 15.8891 0.2804 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8174 17.5087 1.0475 C 0 0 0 0 0 0 0 0 0 0 0 0 19.4631 14.7878 0.4065 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7648 16.6726 0.0172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4847 19.4581 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7545 24.7622 2.7296 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8699 26.3373 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7245 24.7469 -2.7996 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0099 11.0679 -1.1204 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0278 11.0731 1.1866 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7623 8.3735 -1.1279 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7801 8.3786 1.1791 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4902 10.9302 0.0064 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5723 8.1800 1.2045 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5542 8.1749 -1.1025 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4892 20.4231 -0.0456 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0857 6.1310 -0.9897 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4153 5.7568 -2.5375 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1583 3.1043 -2.1133 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7177 3.1616 0.1511 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7429 2.7153 1.1611 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0726 2.3412 -0.3865 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4406 5.3106 -1.5274 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3679 0.7372 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3965 0.2663 -0.1738 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6373 0.0000 -1.6427 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7750 0.3207 -2.4492 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5066 20.1827 -0.1575 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8261 15.8101 -1.4178 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4568 14.0176 -1.2103 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3165 19.7854 1.5344 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9388 17.9804 1.7399 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3140 15.0702 -0.6856 H 0 0 0 0 0 0 0 0 0 0 0 0 20.1368 15.0747 1.6148 H 0 0 0 0 0 0 0 0 0 0 0 0 19.1020 13.4222 0.3814 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 41 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 42 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 43 1 0 0 0 0 13 16 1 0 0 0 0 13 44 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 45 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 22 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 50 1 0 0 0 0 22 30 1 0 0 0 0 22 51 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 53 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 27 31 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 31 32 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 37 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 38 2 0 0 0 0 36 67 1 0 0 0 0 37 39 2 0 0 0 0 37 68 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 39 69 1 0 0 0 0 40 70 1 0 0 0 0 40 71 1 0 0 0 0 40 72 1 0 0 0 0 M END > (365) 364 > (365) C29H32Cl2N8O > (365) 579.5308 > (365) FGFR-P364 > (365) 6-arylpyrido[2,3-d]pyrimidine deriv. 66 > (365) FGFR-1 Tyrosine Kinase > (365) 110 > (365) BINDDB > (365) <2007 > (365) P > (365) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 67 csChFnd70/04170815452D 73 77 0 0 0 0 0 0 0 0999 V2000 3.9640 15.9192 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4689 13.3411 -0.0569 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9879 14.2167 -0.0522 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9923 14.1073 -0.0584 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5481 16.8078 -0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1028 15.8341 -0.0553 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6305 18.6212 -0.0476 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7389 18.3367 -0.0549 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2487 19.3880 -0.0499 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6282 16.6380 -0.0574 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4130 21.2969 -0.0478 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6468 23.9752 1.5051 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7200 24.8638 -0.0441 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4938 22.1968 1.5120 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4950 22.2000 -1.6058 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6480 23.9784 -1.5952 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4015 21.0838 3.4578 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4054 21.0911 -3.5539 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7376 10.6657 -0.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0327 8.7106 -0.0628 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4083 11.5561 -0.0601 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2879 7.7807 -0.0611 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3566 19.1096 -0.0572 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7926 18.1240 -0.0619 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6704 16.5576 -0.0642 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8836 5.4162 -1.3485 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2147 3.4691 -1.2411 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2768 3.0236 -0.2643 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9457 4.9706 -0.3718 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5711 5.9035 -0.0653 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5892 2.5362 -1.5475 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8725 0.6591 -1.5516 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3643 18.8748 -0.0642 N 0 0 3 0 0 0 0 0 0 0 0 0 14.8558 17.8539 0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9007 16.2371 -0.7186 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3734 15.2325 -0.6014 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8030 15.8354 0.2835 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7676 17.4463 1.0567 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3000 18.4640 0.9383 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2661 20.0517 1.6907 O 0 0 0 0 0 0 0 0 0 0 0 0 17.7934 20.5924 2.5767 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7548 16.6162 -0.0509 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4681 19.3939 -0.0443 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7100 24.6733 2.7120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8398 26.2543 -0.0425 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7111 24.6791 -2.8005 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0086 11.0330 -1.2065 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0132 11.0286 1.0938 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7570 8.3476 -1.2151 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7618 8.3433 1.0851 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4721 10.8929 -0.0636 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5634 8.1436 1.0911 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5589 8.1481 -1.2091 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4542 20.3593 -0.0554 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0800 6.1116 -1.0846 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4238 5.7443 -2.6390 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1605 3.0988 -2.2172 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7080 3.1462 0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7366 2.6956 1.0261 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0805 2.3282 -0.5282 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4524 5.2936 -1.6510 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3410 0.6043 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3942 0.2603 -0.3055 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6490 0.0000 -1.7812 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7847 0.3242 -2.5715 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4631 20.1218 -0.1468 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7853 15.7627 -1.4105 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4066 13.9733 -1.2023 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9507 15.0462 0.3718 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8866 17.9132 1.7479 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5935 21.8785 3.1154 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0783 19.6865 3.6171 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8738 20.6246 1.6734 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 69 1 0 0 0 0 38 39 2 0 0 0 0 38 70 1 0 0 0 0 39 40 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (366) 365 > (366) C29H32Cl2N8O2 > (366) 595.5302 > (366) FGFR-P365 > (366) 6-arylpyrido[2,3-d]pyrimidine deriv. 67 > (366) FGFR-1 Tyrosine Kinase > (366) 67 > (366) BINDDB > (366) <2007 > (366) P > (366) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 68 csChFnd70/04170815452D 73 77 0 0 0 0 0 0 0 0999 V2000 3.7433 15.1536 -1.0557 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2385 12.6758 -1.2734 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7901 13.5120 -1.2645 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7052 13.4227 -1.0767 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2673 16.0189 -0.8397 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7885 15.0882 -0.8558 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3220 17.7677 -0.6107 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3409 17.5101 -0.4380 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8809 18.5157 -0.4079 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2569 15.8714 -0.6548 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0140 20.3572 -0.1623 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0989 22.7512 1.6739 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2625 23.7983 0.2967 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9743 21.0345 1.4534 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1867 21.4193 -1.5455 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3099 23.1339 -1.3082 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7682 19.7226 3.1835 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.2471 20.5877 -3.5609 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.5963 10.0869 -1.7189 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9095 8.2034 -1.9401 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2043 10.9544 -1.4975 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2301 7.2973 -2.1714 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8991 18.2639 -0.2346 N 0 0 3 0 0 0 0 0 0 0 0 0 11.3054 17.3213 -0.2601 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2084 15.8103 -0.4612 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8970 5.1823 -3.5874 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2373 3.2931 -3.6976 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3286 2.7290 -3.0140 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9881 4.6182 -2.9037 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5309 5.4890 -2.3839 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6946 2.4223 -4.2175 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9953 0.6138 -4.4299 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8193 18.0536 -0.0624 N 0 0 3 0 0 0 0 0 0 0 0 0 14.2669 17.0627 0.0511 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7796 17.6497 -0.5902 C 0 0 0 0 0 0 0 0 0 0 0 0 17.2091 16.6713 -0.4782 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1377 15.1074 0.2717 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6292 14.5144 0.9151 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1944 15.4951 0.8113 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5608 12.9758 1.6519 O 0 0 0 0 0 0 0 0 0 0 0 0 17.0893 12.0366 1.7210 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5613 15.8197 -1.0562 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1843 18.5066 -0.5936 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0687 23.2771 2.9243 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3594 25.1398 0.4758 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4432 23.9576 -2.3782 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9620 10.5776 -2.8290 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8110 10.2926 -0.6161 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6949 7.9976 -3.0431 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5439 7.7127 -0.8302 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2452 10.3206 -1.5081 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4449 7.5030 -1.0686 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5958 7.7881 -3.2814 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9765 19.4695 -0.0739 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0296 5.8268 -3.1668 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5338 5.6538 -4.8206 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2254 3.0598 -4.6166 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6337 2.8280 -2.4721 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6918 2.2575 -1.7807 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1959 2.0845 -3.4345 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5919 5.0833 -4.1293 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.8515 -1.9847 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4225 0.0798 -3.2436 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8334 0.0000 -4.8149 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9534 0.4200 -5.3890 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9052 19.2675 0.0011 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8387 18.8715 -1.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3843 17.1295 -0.9780 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2570 14.3452 0.3572 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0208 15.0382 1.3162 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8597 10.8360 2.3386 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5472 11.8156 0.4496 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0266 12.7416 2.4277 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 69 1 0 0 0 0 38 39 2 0 0 0 0 38 40 1 0 0 0 0 39 70 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (367) 366 > (367) C29H32Cl2N8O2 > (367) 595.5302 > (367) FGFR-P366 > (367) 6-arylpyrido[2,3-d]pyrimidine deriv. 68 > (367) FGFR-1 Tyrosine Kinase > (367) 63 > (367) BINDDB > (367) <2007 > (367) P > (367) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 69 csChFnd70/04170815452D 73 77 0 0 0 0 0 0 0 0999 V2000 3.9777 15.9731 0.0152 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4858 13.3863 0.0088 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0008 14.2653 0.0184 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0141 14.1539 -0.0043 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5670 16.8635 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1258 15.8860 -0.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6504 18.6823 -0.0034 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7683 18.3955 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2740 19.4506 -0.0178 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6563 16.6914 -0.0223 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4399 21.3653 -0.0240 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6845 24.0576 1.5221 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7496 24.9428 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5301 22.2739 1.5367 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5138 22.2651 -1.5906 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6682 24.0488 -1.5877 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4480 21.1652 3.4931 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4124 21.1452 -3.5397 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7478 10.7036 0.0272 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0428 8.7425 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4241 11.5959 0.0127 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2923 7.8107 0.0438 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3913 19.1697 -0.0414 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8312 18.1803 -0.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7076 16.6092 -0.0459 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8844 5.4332 -1.2473 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2161 3.4804 -1.1338 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2746 3.0388 -0.1358 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9429 4.9914 -0.2493 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5755 5.9276 0.0454 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5836 2.5443 -1.4284 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8668 0.6614 -1.4269 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4078 18.9326 -0.0644 N 0 0 3 0 0 0 0 0 0 0 0 0 14.9038 17.9087 0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9466 16.2853 -0.7225 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4211 15.2770 -0.6064 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8592 15.8860 0.2849 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8169 17.5075 1.0606 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3461 18.5204 0.9386 C 0 0 0 0 0 0 0 0 0 0 0 0 19.3106 14.8924 0.3988 O 0 0 0 0 0 0 0 0 0 0 0 0 20.7429 15.6004 1.3362 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7652 16.6726 0.0174 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4851 19.4581 0.0035 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7550 24.7625 2.7294 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8704 26.3376 -0.0403 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7251 24.7469 -2.7997 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0104 11.0681 -1.1217 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0278 11.0725 1.1856 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7628 8.3736 -1.1297 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7803 8.3780 1.1775 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4907 10.9300 0.0060 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5724 8.1796 1.2023 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5549 8.1750 -1.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4898 20.4232 -0.0450 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0862 6.1310 -0.9919 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4161 5.7574 -2.5403 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1590 3.1046 -2.1167 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7179 3.1613 0.1479 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7430 2.7145 1.1572 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0728 2.3409 -0.3911 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4411 5.3107 -1.5309 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3673 0.7337 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3968 0.2657 -0.1784 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6378 0.0000 -1.6475 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7758 0.3210 -2.4536 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5072 20.1827 -0.1557 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8269 15.8109 -1.4162 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4544 14.0139 -1.2092 H 0 0 0 0 0 0 0 0 0 0 0 0 18.9367 17.9804 1.7551 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3156 19.7856 1.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 21.1552 16.8063 0.7262 H 0 0 0 0 0 0 0 0 0 0 0 0 20.3526 15.8566 2.6697 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8135 14.6784 1.3278 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 22 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 51 1 0 0 0 0 22 30 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 31 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 29 30 1 0 0 0 0 29 61 1 0 0 0 0 29 62 1 0 0 0 0 31 32 1 0 0 0 0 32 63 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 33 34 1 0 0 0 0 33 66 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 36 37 2 0 0 0 0 36 68 1 0 0 0 0 37 38 1 0 0 0 0 37 40 1 0 0 0 0 38 39 2 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 40 41 1 0 0 0 0 41 71 1 0 0 0 0 41 72 1 0 0 0 0 41 73 1 0 0 0 0 M END > (368) 367 > (368) C29H32Cl2N8O2 > (368) 595.5302 > (368) FGFR-P367 > (368) 6-arylpyrido[2,3-d]pyrimidine deriv. 69 > (368) FGFR-1 Tyrosine Kinase > (368) 74 > (368) BINDDB > (368) <2007 > (368) P > (368) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 70 csChFnd70/04170815452D 75 80 0 0 0 0 0 0 0 0999 V2000 3.6163 14.5226 -0.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9888 12.1706 -0.0345 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6379 12.9694 -0.0285 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3784 12.8692 -0.0390 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0615 15.3330 -0.0314 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4794 14.4445 -0.0377 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1369 16.9870 -0.0304 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9725 16.7272 -0.0420 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6131 17.6864 -0.0357 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8711 15.1776 -0.0428 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7633 19.4276 -0.0356 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9802 21.8719 1.3786 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0451 22.6812 -0.0354 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8398 20.2497 1.3865 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8356 20.2503 -1.4575 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9762 21.8725 -1.4495 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7578 19.2360 3.1625 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.7499 19.2373 -3.2337 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4091 9.7303 -0.0311 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6780 7.9469 -0.0341 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9333 10.5423 -0.0361 N 0 0 3 0 0 0 0 0 0 0 0 0 2.0862 7.0988 -0.0290 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4482 17.4320 -0.0478 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7580 16.5327 -0.0543 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6461 15.1039 -0.0551 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5394 4.9407 -1.2042 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8413 3.1647 -1.1053 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1629 2.7593 -0.2090 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8609 4.5353 -0.3079 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3444 5.3864 -0.0318 N 0 0 0 0 0 0 0 0 0 0 0 0 2.3580 2.3136 -1.3813 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6161 0.6012 -1.3841 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1917 17.2175 -0.0601 N 0 0 3 0 0 0 0 0 0 0 0 0 13.5471 16.2897 0.0456 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2433 14.3960 0.2316 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9383 13.8892 -0.5535 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5930 14.8231 -0.6519 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2472 15.8869 0.9534 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8846 16.8481 0.8617 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8899 18.3369 1.5844 C 0 0 0 0 0 0 0 0 0 0 0 0 16.2014 18.8375 2.3626 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5424 17.8931 2.4534 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5795 16.4433 1.7670 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5133 15.1585 -0.0270 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0768 17.6923 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0399 22.5096 2.4790 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1545 23.9497 -0.0352 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0318 22.5108 -2.5496 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7422 10.0646 -1.0773 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7503 10.0624 1.0208 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3368 7.6147 -1.0862 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3447 7.6126 1.0121 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9034 9.9372 -0.0404 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4273 7.4308 1.0231 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4193 7.4331 -1.0752 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5373 18.5720 -0.0474 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6312 5.5751 -0.9659 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1178 5.2391 -2.3808 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7024 2.8259 -1.9970 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2933 2.8710 0.0611 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5845 2.4610 0.9676 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0711 2.1249 -0.4472 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4089 4.8290 -1.4743 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.8742 0.5836 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0940 0.2382 -0.2480 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4994 0.0000 -1.5909 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4465 0.2948 -2.3159 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2818 18.3547 -0.1378 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2763 13.6544 0.2956 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9455 12.7416 -1.1049 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5734 14.3937 -1.2817 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8592 19.0814 1.5229 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2025 19.9837 2.9171 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5676 18.3179 3.0774 H 0 0 0 0 0 0 0 0 0 0 0 0 18.6267 15.7239 1.8475 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 44 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 21 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 45 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 23 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 46 1 0 0 0 0 13 16 1 0 0 0 0 13 47 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 48 1 0 0 0 0 19 21 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 22 30 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 24 1 0 0 0 0 23 56 1 0 0 0 0 24 25 2 0 0 0 0 24 33 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 31 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 61 1 0 0 0 0 28 62 1 0 0 0 0 29 30 1 0 0 0 0 29 63 1 0 0 0 0 29 64 1 0 0 0 0 31 32 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 33 68 1 0 0 0 0 34 39 2 0 0 0 0 34 37 1 0 0 0 0 35 38 2 0 0 0 0 35 36 1 0 0 0 0 35 69 1 0 0 0 0 36 37 2 0 0 0 0 36 70 1 0 0 0 0 37 71 1 0 0 0 0 38 43 1 0 0 0 0 38 39 1 0 0 0 0 39 40 1 0 0 0 0 40 41 2 0 0 0 0 40 72 1 0 0 0 0 41 42 1 0 0 0 0 41 73 1 0 0 0 0 42 43 2 0 0 0 0 42 74 1 0 0 0 0 43 75 1 0 0 0 0 M END > (369) 368 > (369) C32H32Cl2N8O > (369) 615.5638 > (369) FGFR-P368 > (369) 6-arylpyrido[2,3-d]pyrimidine deriv. 70 > (369) FGFR-1 Tyrosine Kinase > (369) 300 > (369) BINDDB > (369) <2007 > (369) P > (369) TRAIN $$$$ 1,6-naphthyridin 23 csChFnd70/04170815452D 80 82 0 0 0 0 0 0 0 0999 V2000 1.0153 15.6708 0.6533 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8100 12.7700 0.4828 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5618 13.1548 0.4144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7600 16.1919 0.5916 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0774 14.9038 0.4685 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2401 17.9543 0.6473 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2278 17.0039 0.4573 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9930 18.3555 0.5791 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6131 14.0130 0.5978 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7506 15.3617 0.4061 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5697 20.1934 0.6329 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3643 23.1281 -0.4252 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8224 21.4118 -0.4789 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8548 20.7073 1.8007 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3907 22.4257 1.8476 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6493 23.6339 0.7337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6367 24.3171 -1.5096 O 0 0 0 0 0 0 0 0 0 0 0 0 5.2571 26.0631 -1.3847 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6436 22.9281 2.9865 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1334 24.7193 2.9648 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2844 11.0424 0.4300 N 0 0 3 0 0 0 0 0 0 0 0 0 2.5829 9.6557 0.3034 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6668 7.8913 0.2682 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0230 6.4430 0.1361 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1069 4.6785 0.1008 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4090 3.2881 -0.0260 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6098 1.5756 0.2455 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2390 1.3169 2.1817 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3240 3.3583 -1.7001 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9810 2.2641 -1.5961 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9833 17.4155 0.3887 N 0 0 3 0 0 0 0 0 0 0 0 0 9.1779 16.1399 0.2710 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7184 14.6290 0.2248 O 0 0 0 0 0 0 0 0 0 0 0 0 10.8819 16.5395 0.2043 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8680 14.1035 -1.5833 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1806 15.1531 0.0763 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0004 15.9525 0.0221 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0294 13.9556 1.6563 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.6347 0.7527 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5164 12.1300 0.3216 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2703 18.9649 0.7402 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8224 21.0187 -1.3818 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4322 19.7675 2.6685 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0694 24.9726 0.7729 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5700 26.8765 -2.3190 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0293 26.5525 -0.0751 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6454 26.0919 -1.6647 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0044 25.5213 3.2628 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1418 24.9449 3.9338 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6277 25.0581 1.6813 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0578 10.7550 0.4771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3357 9.8208 -0.8850 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4488 9.7160 1.4230 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9141 7.7263 1.4568 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8011 7.8310 -0.8512 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7757 6.6080 -1.0524 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8888 6.5033 1.2556 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3542 4.5135 1.2894 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2411 4.6182 -1.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3965 1.5001 -0.4818 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4943 0.5651 -0.2051 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7646 0.0000 2.3998 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4302 1.5182 2.9217 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2582 2.2480 2.6033 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4837 2.8468 -2.7194 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6628 4.7014 -1.9970 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6501 2.3008 -2.8442 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8299 2.7872 -0.5897 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6436 0.9252 -1.2803 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3499 18.6210 0.4255 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2485 17.7452 0.2411 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9757 14.9566 -2.7089 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8342 13.0720 -1.6785 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5715 13.5340 -1.5447 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2230 16.7003 1.2044 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9665 14.9209 -0.0732 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1080 16.8057 -1.1035 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7329 13.3861 1.6948 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9956 12.9240 1.5610 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2520 14.7034 2.8385 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 39 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 40 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 41 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 31 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 42 1 0 0 0 0 14 15 1 0 0 0 0 14 43 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 44 1 0 0 0 0 17 18 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 19 20 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 22 1 0 0 0 0 21 51 1 0 0 0 0 22 23 1 0 0 0 0 22 52 1 0 0 0 0 22 53 1 0 0 0 0 23 24 1 0 0 0 0 23 54 1 0 0 0 0 23 55 1 0 0 0 0 24 25 1 0 0 0 0 24 56 1 0 0 0 0 24 57 1 0 0 0 0 25 26 1 0 0 0 0 25 58 1 0 0 0 0 25 59 1 0 0 0 0 26 27 1 0 0 0 0 26 29 1 0 0 0 0 27 28 1 0 0 0 0 27 60 1 0 0 0 0 27 61 1 0 0 0 0 28 62 1 0 0 0 0 28 63 1 0 0 0 0 28 64 1 0 0 0 0 29 30 1 0 0 0 0 29 65 1 0 0 0 0 29 66 1 0 0 0 0 30 67 1 0 0 0 0 30 68 1 0 0 0 0 30 69 1 0 0 0 0 31 32 1 0 0 0 0 31 70 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 34 36 1 0 0 0 0 34 71 1 0 0 0 0 35 36 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 35 74 1 0 0 0 0 36 37 1 0 0 0 0 36 38 1 0 0 0 0 37 75 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 38 78 1 0 0 0 0 38 79 1 0 0 0 0 38 80 1 0 0 0 0 M END > (38) 36 > (38) C29H42N6O3 > (38) 522.6892 > (38) FGFR-P36 > (38) 1,6-naphthyridine 23 > (38) FGFR-1 Tyrosine Kinase > (38) 25 > (38) BINDDB > (38) <2007 > (38) P > (38) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 73 csChFnd70/04170815452D 62 64 0 0 0 0 0 0 0 0999 V2000 7.4168 12.6554 0.6022 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2387 9.7684 0.4206 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0132 10.9912 0.5022 N 0 0 0 0 0 0 0 0 0 0 0 0 9.9170 10.1340 0.4341 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1848 13.1249 0.6217 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4576 11.7881 0.5328 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7197 14.8705 0.7255 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6814 13.8168 0.6445 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4907 15.2131 0.7365 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1474 12.1897 0.5480 N 0 0 0 0 0 0 0 0 0 0 0 0 12.1293 17.0312 0.8434 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0352 19.4890 2.5523 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3235 20.4283 1.0432 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4397 17.7948 2.4614 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4297 17.9828 -0.6737 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0253 19.6759 -0.5652 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0774 16.6187 4.3568 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.0562 17.0409 -2.6936 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.7321 8.0453 0.3175 N 0 0 3 0 0 0 0 0 0 0 0 0 5.8788 7.5955 0.2997 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6767 5.6177 0.1792 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7412 5.1481 0.1608 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5471 3.2492 0.0452 N 0 0 0 0 0 0 0 0 0 0 0 0 1.7302 2.7272 0.3334 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3049 2.8473 2.2754 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1901 2.5955 -1.6330 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4551 0.6247 -1.5203 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4525 14.1652 0.6553 N 0 0 3 0 0 0 0 0 0 0 0 0 15.6065 12.8466 0.5677 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8857 10.7414 0.4430 S 0 0 0 0 0 0 0 0 0 0 0 0 17.3280 13.1852 0.5783 N 0 0 3 0 0 0 0 0 0 0 0 0 18.5824 11.7518 0.4830 C 0 0 0 0 0 0 0 0 0 0 0 0 20.4335 12.4862 0.5169 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4117 13.6365 0.6619 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7795 15.9135 0.7940 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2761 20.0819 3.8042 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7892 21.7525 1.1212 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2584 20.4142 -1.7388 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6036 7.1335 0.2568 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2675 8.0618 1.4924 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2553 8.2037 -0.8204 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2880 5.1515 -1.0133 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3002 5.0095 1.2994 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1299 5.6143 1.3533 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1176 5.7563 -0.9594 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8693 3.5898 -0.3935 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5457 1.3919 -0.1096 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3658 4.2029 2.6901 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.3401 2.5062 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2462 2.0841 3.0138 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2434 2.8881 -2.6486 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4250 3.2218 -1.9429 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4161 0.3333 -0.5177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2242 0.0000 -1.1915 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9138 0.1368 -2.7712 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8610 15.3580 0.7260 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7365 14.3779 0.6489 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3965 10.8861 1.5918 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3828 11.0279 -0.7209 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6194 13.3518 -0.5918 H 0 0 0 0 0 0 0 0 0 0 0 0 20.6331 13.2102 1.7210 H 0 0 0 0 0 0 0 0 0 0 0 0 21.3669 11.4197 0.4461 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 34 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 27 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 29 1 0 0 0 0 28 56 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 31 32 1 0 0 0 0 31 57 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (372) 371 > (372) C23H29Cl2N7S > (372) 506.495 > (372) FGFR-P371 > (372) 6-arylpyrido[2,3-d]pyrimidine deriv. 73 > (372) FGFR-1 Tyrosine Kinase > (372) 260 > (372) BINDDB > (372) <2007 > (372) P > (372) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 74 csChFnd70/04170815452D 63 65 0 0 0 0 0 0 0 0999 V2000 7.6476 12.8295 -0.3246 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4493 9.8929 -0.2687 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2217 11.1461 -0.2856 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1522 10.2453 -0.2896 N 0 0 0 0 0 0 0 0 0 0 0 0 9.4422 13.2862 -0.3485 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7166 11.9168 -0.3294 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0018 15.0504 -0.3909 C 0 0 0 0 0 0 0 0 0 0 0 0 12.9891 13.9496 -0.3916 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7980 15.3785 -0.4125 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4316 12.3056 -0.3518 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4635 17.2152 -0.4580 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4103 19.8284 1.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7061 20.6470 -0.5430 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7906 18.1174 1.1100 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7721 18.0453 -2.0689 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3920 19.7567 -2.1023 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4189 17.0926 3.1214 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.3787 16.9301 -4.0274 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.9186 8.1511 -0.2276 N 0 0 3 0 0 0 0 0 0 0 0 0 6.0377 7.7154 -0.2035 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8126 5.7120 -0.1592 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8482 5.2569 -0.1342 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6319 3.3335 -0.0917 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2965 2.5971 1.5709 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5413 0.6053 1.3735 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7831 2.8367 -0.3805 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3295 3.0417 -2.3346 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7850 14.2835 -0.4133 N 0 0 3 0 0 0 0 0 0 0 0 0 15.9655 12.9033 -0.3933 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7468 13.2344 -0.4149 N 0 0 3 0 0 0 0 0 0 0 0 0 19.0018 11.7673 -0.3937 C 0 0 0 0 0 0 0 0 0 0 0 0 20.8833 12.4918 -0.4245 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3935 11.2848 -0.3539 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6403 13.8348 -0.3440 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0608 16.1183 -0.4066 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6642 20.5284 2.2717 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1908 21.9850 -0.5762 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6315 20.4010 -3.3487 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7913 7.2171 -0.2146 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4276 8.2916 0.9623 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4092 8.2420 -1.3830 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4227 5.1357 -1.3250 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4410 5.1854 1.0201 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2380 5.8332 1.0317 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2197 5.7836 -1.3135 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5577 3.2050 1.8936 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3543 2.8620 2.6225 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0161 0.0561 2.6132 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2843 0.0000 1.0320 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4981 0.3411 0.3352 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5870 1.4698 0.0158 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9306 3.6888 0.4009 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4010 4.4290 -2.6998 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2644 2.2896 -3.1246 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5520 -2.5714 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2107 15.4884 -0.4427 H 0 0 0 0 0 0 0 0 0 0 0 0 18.1726 14.4394 -0.4443 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8080 10.9886 0.7979 H 0 0 0 0 0 0 0 0 0 0 0 0 18.7889 10.9383 -1.5473 H 0 0 0 0 0 0 0 0 0 0 0 0 21.8170 11.4001 -0.4087 H 0 0 0 0 0 0 0 0 0 0 0 0 21.0771 13.2704 -1.6160 H 0 0 0 0 0 0 0 0 0 0 0 0 21.0962 13.3207 0.7292 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2245 10.3134 -0.3398 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 34 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 35 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 28 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 36 1 0 0 0 0 13 16 1 0 0 0 0 13 37 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 20 21 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 21 43 1 0 0 0 0 22 23 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 27 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 28 29 1 0 0 0 0 28 56 1 0 0 0 0 29 30 1 0 0 0 0 29 33 2 0 0 0 0 30 31 1 0 0 0 0 30 57 1 0 0 0 0 31 32 1 0 0 0 0 31 58 1 0 0 0 0 31 59 1 0 0 0 0 32 60 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 33 63 1 0 0 0 0 M END > (373) 372 > (373) C23H30Cl2N8 > (373) 489.4496 > (373) FGFR-P372 > (373) 6-arylpyrido[2,3-d]pyrimidine deriv. 74 > (373) FGFR-1 Tyrosine Kinase > (373) 2700 > (373) BINDDB > (373) <2007 > (373) P > (373) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 75 csChFnd70/04170815452D 81 84 0 0 0 0 0 0 0 0999 V2000 6.0078 15.0674 0.0105 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7516 12.6070 -0.3943 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1924 13.3439 -0.0771 N 0 0 0 0 0 0 0 0 0 0 0 0 9.1981 13.5388 -0.6393 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5032 16.1293 -0.2397 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1451 15.3004 -0.5756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4139 17.9758 -0.1670 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5401 18.0041 -0.7577 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9546 18.9179 -0.4302 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5901 16.2705 -0.8197 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9380 20.8697 -0.3687 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2078 23.5636 1.2695 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9062 24.5165 -0.2537 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2252 21.7450 1.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6426 21.8384 -1.9017 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6287 23.6565 -1.8356 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6025 20.5513 3.1342 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.2941 20.7614 -3.8883 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8596 10.7916 -0.4702 N 0 0 3 0 0 0 0 0 0 0 0 0 6.2778 9.7190 -0.2040 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7566 7.7673 -0.3542 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0791 18.9518 -1.0210 N 0 0 3 0 0 0 0 0 0 0 0 0 13.6037 18.0990 -1.3360 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0996 19.0200 -1.5917 N 0 0 3 0 0 0 0 0 0 0 0 0 16.7569 18.0929 -1.9341 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1047 6.6470 -0.0760 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5835 4.6953 -0.2262 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9974 3.6197 0.0408 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7251 3.8930 -1.3912 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9271 3.1694 -0.8394 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4511 1.7472 0.2172 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2177 1.4115 2.0504 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6405 15.8455 -1.4109 S 0 0 0 0 0 0 0 0 0 0 0 0 18.2403 19.4356 -2.1748 C 0 0 0 0 0 0 0 0 0 0 0 0 19.9711 18.4674 -2.5323 C 0 0 0 0 0 0 0 0 0 0 0 0 23.1232 18.8830 -2.7978 C 0 0 0 0 0 0 0 0 0 0 0 0 21.3380 21.1095 -1.3794 C 0 0 0 0 0 0 0 0 0 0 0 0 22.7920 22.4660 -1.7148 C 0 0 0 0 0 0 0 0 0 0 0 0 24.5592 20.2617 -3.1190 C 0 0 0 0 0 0 0 0 0 0 0 0 21.3955 19.7566 -2.7635 N 0 0 0 0 0 0 0 0 0 0 0 0 24.4570 21.5876 -1.7848 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7352 15.6509 0.2630 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1821 18.6408 0.0856 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4300 24.2430 2.4994 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8943 25.9383 -0.2090 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4000 24.4080 -3.0215 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9827 10.2275 -0.6998 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7365 9.9800 1.0998 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3012 10.0504 -1.2027 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2980 7.5062 -1.6580 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7333 7.4359 0.6446 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0583 20.2285 -0.9785 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0788 20.2967 -1.5492 H 0 0 0 0 0 0 0 0 0 0 0 0 17.0634 17.2351 -0.8244 H 0 0 0 0 0 0 0 0 0 0 0 0 16.6268 17.3046 -3.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5633 6.9081 1.2278 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1280 6.9784 -1.0748 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1248 4.4343 -1.5301 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5601 4.3639 0.7725 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6112 5.2971 -1.6685 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1759 3.2075 -2.5692 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0546 1.7809 -0.4972 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4457 3.9004 0.2986 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.3113 -1.9263 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2706 0.9498 0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4221 1.3941 -0.7796 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4862 2.0736 2.1673 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3180 1.9217 3.0461 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3950 0.0000 2.2439 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9338 20.2936 -3.2844 H 0 0 0 0 0 0 0 0 0 0 0 0 18.3704 20.2240 -0.9821 H 0 0 0 0 0 0 0 0 0 0 0 0 20.2776 17.6095 -1.4226 H 0 0 0 0 0 0 0 0 0 0 0 0 19.8410 17.6791 -3.7251 H 0 0 0 0 0 0 0 0 0 0 0 0 23.1478 17.9103 -3.8535 H 0 0 0 0 0 0 0 0 0 0 0 0 23.3564 18.2320 -1.5396 H 0 0 0 0 0 0 0 0 0 0 0 0 21.5427 20.4942 -0.0985 H 0 0 0 0 0 0 0 0 0 0 0 0 20.0595 21.7623 -1.3998 H 0 0 0 0 0 0 0 0 0 0 0 0 22.5481 23.1315 -2.9633 H 0 0 0 0 0 0 0 0 0 0 0 0 22.8030 23.4299 -0.6509 H 0 0 0 0 0 0 0 0 0 0 0 0 25.8483 19.6316 -3.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 24.3668 20.8631 -4.4083 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 42 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 43 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 44 1 0 0 0 0 13 16 1 0 0 0 0 13 45 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 20 21 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 26 1 0 0 0 0 21 50 1 0 0 0 0 21 51 1 0 0 0 0 22 23 1 0 0 0 0 22 52 1 0 0 0 0 23 24 1 0 0 0 0 23 33 2 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 25 34 1 0 0 0 0 25 54 1 0 0 0 0 25 55 1 0 0 0 0 26 27 1 0 0 0 0 26 56 1 0 0 0 0 26 57 1 0 0 0 0 27 28 1 0 0 0 0 27 58 1 0 0 0 0 27 59 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 31 32 1 0 0 0 0 31 65 1 0 0 0 0 31 66 1 0 0 0 0 32 67 1 0 0 0 0 32 68 1 0 0 0 0 32 69 1 0 0 0 0 34 35 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 35 40 1 0 0 0 0 35 72 1 0 0 0 0 35 73 1 0 0 0 0 36 40 1 0 0 0 0 36 39 1 0 0 0 0 36 74 1 0 0 0 0 36 75 1 0 0 0 0 37 40 1 0 0 0 0 37 38 1 0 0 0 0 37 76 1 0 0 0 0 37 77 1 0 0 0 0 38 41 1 0 0 0 0 38 78 1 0 0 0 0 38 79 1 0 0 0 0 39 41 1 0 0 0 0 39 80 1 0 0 0 0 39 81 1 0 0 0 0 M END > (374) 373 > (374) C29H40Cl2N8OS > (374) 619.654 > (374) FGFR-P373 > (374) 6-arylpyrido[2,3-d]pyrimidine deriv. 75 > (374) FGFR-1 Tyrosine Kinase > (374) 130 > (374) BINDDB > (374) <2007 > (374) P > (374) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 76 csChFnd70/04170815452D 66 69 0 0 0 0 0 0 0 0999 V2000 3.9900 16.0163 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5036 13.4206 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0133 14.3024 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0371 14.1911 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5849 16.9100 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1492 15.9292 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6688 18.7350 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7974 18.4474 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2981 19.5061 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6850 16.7375 -0.0295 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4646 21.4274 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7141 24.1176 1.5761 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7764 25.0173 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5584 22.3276 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5359 22.3418 -1.5601 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6916 24.1316 -1.5444 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4788 21.2009 3.5332 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4296 21.2325 -3.5240 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4417 11.6241 -0.0254 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7594 10.7285 -0.0142 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0557 8.7606 -0.0276 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4266 19.2248 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8715 18.2320 -0.0529 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2989 7.8253 -0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7478 16.6594 -0.0597 O 0 0 0 0 0 0 0 0 0 0 0 0 13.6405 19.0760 -0.0659 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0472 17.6683 -0.0867 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8433 18.5253 -0.1000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8943 5.4492 -1.3320 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2273 3.4888 -1.2331 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2774 3.0382 -0.2291 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9444 4.9984 -0.3279 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5832 5.9358 -0.0286 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5884 2.5516 -1.5323 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8726 0.6620 -1.5452 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7731 16.7183 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4994 19.5135 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7867 24.8161 2.7929 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8983 26.4169 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7469 24.8410 -2.7557 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5119 10.9560 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0394 11.0902 1.1524 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0173 11.1026 -1.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7758 8.3990 -1.1941 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7979 8.3864 1.1212 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5256 20.4825 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5787 8.1870 1.1508 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5566 8.1994 -1.1645 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7680 19.8886 -1.2209 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7906 19.8769 1.0944 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9197 16.8556 1.0681 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8971 16.8673 -1.2472 H 0 0 0 0 0 0 0 0 0 0 0 0 17.8454 17.5223 -0.1149 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9707 19.3379 -1.2549 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9934 19.3262 1.0604 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1005 6.1476 -1.0730 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4216 5.7840 -2.6262 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1716 3.1190 -2.2239 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7334 3.1592 0.0497 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7499 2.7034 1.0651 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0710 2.3399 -0.4880 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4382 5.3282 -1.6107 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3685 0.6628 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4071 0.2560 -0.2963 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6390 0.0000 -1.7692 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7828 0.3280 -2.5798 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 36 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 37 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 38 1 0 0 0 0 13 16 1 0 0 0 0 13 39 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 40 1 0 0 0 0 19 20 1 0 0 0 0 19 41 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 24 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 23 25 2 0 0 0 0 23 26 1 0 0 0 0 24 33 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 26 27 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 30 34 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 34 1 0 0 0 0 31 32 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 32 33 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 34 35 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 M END > (375) 374 > (375) C25H31Cl2N7O > (375) 516.4722 > (375) FGFR-P374 > (375) 6-arylpyrido[2,3-d]pyrimidine deriv. 76 > (375) FGFR-1 Tyrosine Kinase > (375) 3700 > (375) BINDDB > (375) <2007 > (375) P > (375) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 77 csChFnd70/04170815452D 72 75 0 0 0 0 0 0 0 0999 V2000 3.9761 15.9604 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4844 13.3738 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9993 14.2526 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0125 14.1417 -0.0267 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5653 16.8510 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1243 15.8737 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6490 18.6697 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7667 18.3831 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2727 19.4381 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6547 16.6791 -0.0294 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4386 21.3527 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6872 24.0335 1.5706 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7492 24.9301 0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5320 22.2498 1.5726 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5096 22.2639 -1.5547 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6647 24.0475 -1.5390 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4527 21.1269 3.5209 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4037 21.1584 -3.5117 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4227 11.5836 -0.0253 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7464 10.6911 -0.0141 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0415 8.7300 -0.0275 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3902 19.1577 -0.0338 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8301 18.1685 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2910 7.7980 -0.0157 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7069 16.6012 -0.0595 O 0 0 0 0 0 0 0 0 0 0 0 0 13.5930 19.0095 -0.0657 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8806 5.4301 -1.3273 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2125 3.4766 -1.2288 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2729 3.0277 -0.2283 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9411 4.9811 -0.3268 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5742 5.9151 -0.0285 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5794 2.5427 -1.5269 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8626 0.6598 -1.5398 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7848 16.4865 -1.7095 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7845 18.4608 -0.0997 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9947 17.6066 -0.0864 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8163 16.4700 1.5289 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7635 16.6600 0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4837 19.4455 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7595 24.7296 2.7832 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8707 26.3249 0.0248 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7198 24.7545 -2.7461 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4892 10.9178 -0.0390 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0288 11.0516 1.1483 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0068 11.0639 -1.1587 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7591 8.3696 -1.1899 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7812 8.3572 1.1172 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4889 20.4112 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5732 8.1585 1.1467 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5512 8.1708 -1.1603 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7200 19.8193 -1.2166 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7426 19.8076 1.0906 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0828 6.1261 -1.0692 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4097 5.7638 -2.6170 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1536 3.1081 -2.2162 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7169 3.1481 0.0495 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7438 2.6940 1.0613 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0708 2.3317 -0.4864 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4367 5.3096 -1.6051 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3496 0.6606 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3952 0.2551 -0.2953 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6332 0.0000 -1.7630 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7697 0.3269 -2.5708 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9119 17.2962 -2.8604 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7834 15.4869 -1.7242 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5096 15.8780 -1.7001 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9341 19.2588 1.0566 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7832 17.4612 -0.1145 H 0 0 0 0 0 0 0 0 0 0 0 0 16.9116 19.2705 -1.2504 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5413 15.8617 1.5382 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8150 15.4706 1.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9659 17.2682 2.6852 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 38 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 24 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 23 1 0 0 0 0 22 48 1 0 0 0 0 23 25 2 0 0 0 0 23 26 1 0 0 0 0 24 31 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 26 36 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 27 31 1 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 27 54 1 0 0 0 0 28 32 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 29 32 1 0 0 0 0 29 30 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 30 31 1 0 0 0 0 30 59 1 0 0 0 0 30 60 1 0 0 0 0 32 33 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 36 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 35 36 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 35 69 1 0 0 0 0 36 37 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 37 72 1 0 0 0 0 M END > (376) 375 > (376) C27H35Cl2N7O > (376) 544.5258 > (376) FGFR-P375 > (376) 6-arylpyrido[2,3-d]pyrimidine deriv. 77 > (376) FGFR-1 Tyrosine Kinase > (376) 8000 > (376) BINDDB > (376) <2007 > (376) P > (376) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 78 csChFnd70/04170815452D 70 74 0 0 0 0 0 0 0 0999 V2000 3.9944 16.0340 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5097 13.4354 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0177 14.3183 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0449 14.2069 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5911 16.9288 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1571 15.9469 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6751 18.7558 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8071 18.4678 -0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3062 19.5277 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6946 16.7561 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4729 21.4512 0.0055 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7227 24.1444 1.5779 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7850 25.0451 0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5668 22.3524 1.5799 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5443 22.3666 -1.5619 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7002 24.1584 -1.5461 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4871 21.2244 3.5372 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4379 21.2560 -3.5280 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4477 11.6369 -0.0254 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7637 10.7403 -0.0142 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0602 8.7703 -0.0276 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4381 19.2461 -0.0340 N 0 0 3 0 0 0 0 0 0 0 0 0 11.8846 18.2522 -0.0530 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3015 7.8340 -0.0158 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7608 16.6778 -0.0598 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8986 5.4553 -1.3335 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2320 3.4927 -1.2345 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2788 3.0416 -0.2293 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9454 5.0040 -0.3283 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5861 5.9424 -0.0286 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5913 2.5544 -1.5340 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8758 0.6628 -1.5469 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6556 19.0972 -0.0660 C 0 0 0 0 0 0 0 0 0 0 0 0 15.0426 17.7090 -0.0866 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6636 17.0802 -1.6549 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9358 15.8069 -1.6737 C 0 0 0 0 0 0 0 0 0 0 0 0 17.5875 15.1627 -0.1242 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9674 15.7923 1.4440 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6992 17.0698 1.4628 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7762 16.7368 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5044 19.5351 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7953 24.8436 2.7960 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9070 26.4463 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7555 24.8686 -2.7588 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5192 10.9681 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0428 11.1025 1.1536 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0206 11.1149 -1.1641 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7811 8.4083 -1.1954 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8032 8.3957 1.1224 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5372 20.5053 -0.0285 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5805 8.1961 1.1521 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5584 8.2085 -1.1657 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1063 6.1544 -1.0742 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4255 5.7904 -2.6291 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1774 3.1225 -2.2264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7386 3.1627 0.0497 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7519 2.7064 1.0663 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0711 2.3424 -0.4886 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4387 5.3342 -1.6125 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3744 0.6636 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4109 0.2563 -0.2966 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6408 0.0000 -1.7711 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3284 -2.5827 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7832 19.9107 -1.2223 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8059 19.8990 1.0956 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1545 17.5835 -2.8654 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4203 15.3149 -2.8990 H 0 0 0 0 0 0 0 0 0 0 0 0 18.5809 14.1671 -0.1389 H 0 0 0 0 0 0 0 0 0 0 0 0 17.4763 15.2887 2.6546 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2183 17.5651 2.6880 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 24 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 23 1 0 0 0 0 22 50 1 0 0 0 0 23 25 2 0 0 0 0 23 33 1 0 0 0 0 24 30 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 26 30 1 0 0 0 0 26 27 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 31 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 31 1 0 0 0 0 28 29 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 29 30 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 31 32 1 0 0 0 0 32 61 1 0 0 0 0 32 62 1 0 0 0 0 32 63 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 68 1 0 0 0 0 38 39 2 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 M END > (377) 376 > (377) C29H31Cl2N7O > (377) 564.5162 > (377) FGFR-P376 > (377) 6-arylpyrido[2,3-d]pyrimidine deriv. 78 > (377) FGFR-1 Tyrosine Kinase > (377) 6800 > (377) BINDDB > (377) <2007 > (377) P > (377) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 79 csChFnd70/04170815452D 68 72 0 0 0 0 0 0 0 0999 V2000 3.9932 16.0356 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5083 13.4369 -0.0164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0165 14.3195 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 7.0436 14.2086 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5891 16.9303 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1553 15.9486 -0.0186 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6723 18.7582 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8050 18.4710 -0.0219 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3021 19.5308 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6930 16.7581 -0.0296 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4674 21.4543 0.0056 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7152 24.1477 1.5781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7776 25.0485 0.0195 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5606 22.3556 1.5799 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5381 22.3698 -1.5618 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6928 24.1618 -1.5460 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4817 21.2275 3.5373 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4325 21.2591 -3.5280 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4467 11.6383 -0.0249 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7627 10.7415 -0.0129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0595 8.7713 -0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4294 19.2469 -0.0339 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3011 7.8349 -0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6419 19.1942 -0.1107 O 0 0 0 0 0 0 0 0 0 0 0 0 3.8980 5.4557 -1.3305 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2318 3.4933 -1.2309 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2789 3.0422 -0.2250 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9452 5.0044 -0.3246 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5859 5.9432 -0.0256 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5913 2.5547 -1.5299 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8761 0.6631 -1.5422 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9858 16.7551 1.2688 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2072 18.0266 -0.0573 S 0 0 0 0 0 0 0 0 0 0 0 0 12.2236 16.8886 -2.0497 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0232 17.6104 -3.4921 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4434 15.2707 -2.1686 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4561 14.3780 -3.7317 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2487 15.1032 -5.1761 C 0 0 0 0 0 0 0 0 0 0 0 0 13.0359 16.7176 -5.0551 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7751 16.7383 0.0217 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5012 19.5368 0.0250 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7878 24.8470 2.7960 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8985 26.4497 0.0249 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7471 24.8722 -2.7587 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5182 10.9696 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0420 11.1038 1.1550 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0195 11.1156 -1.1628 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7803 8.4090 -1.1936 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8028 8.3973 1.1242 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5279 20.5061 -0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5803 8.1972 1.1546 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5576 8.2089 -1.1632 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1057 6.1552 -1.0717 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4247 5.7905 -2.6261 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1770 3.1229 -2.2229 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7388 3.1638 0.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7523 2.7075 1.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0712 2.3426 -0.4838 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4383 5.3340 -1.6088 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.3750 0.6674 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4115 0.2571 -0.2918 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6412 0.0000 -1.7658 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7871 0.3286 -2.5781 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6374 18.8720 -3.3976 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8240 14.7041 -1.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8473 13.1135 -3.8243 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2593 14.4055 -6.3972 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6602 17.2819 -6.1820 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 33 1 0 0 0 0 22 50 1 0 0 0 0 23 29 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 33 2 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 30 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 29 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 30 31 1 0 0 0 0 31 61 1 0 0 0 0 31 62 1 0 0 0 0 31 63 1 0 0 0 0 32 33 2 0 0 0 0 33 34 1 0 0 0 0 34 35 2 0 0 0 0 34 36 1 0 0 0 0 35 39 1 0 0 0 0 35 64 1 0 0 0 0 36 37 2 0 0 0 0 36 65 1 0 0 0 0 37 38 1 0 0 0 0 37 66 1 0 0 0 0 38 39 2 0 0 0 0 38 67 1 0 0 0 0 39 68 1 0 0 0 0 M END > (378) 377 > (378) C27H29Cl2N7O2S > (378) 586.5378 > (378) FGFR-P377 > (378) 6-arylpyrido[2,3-d]pyrimidine deriv. 79 > (378) FGFR-1 Tyrosine Kinase > (378) 68 > (378) BINDDB > (378) <2007 > (378) P > (378) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 80 csChFnd70/04170815452D 70 74 0 0 0 0 0 0 0 0999 V2000 3.9146 15.5389 -2.0841 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4397 12.9548 -2.2295 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9594 13.8454 -2.3421 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9416 13.6962 -1.8571 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4751 16.4011 -1.6829 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0298 15.4118 -1.5729 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5342 18.2033 -1.3907 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6223 17.8788 -0.9156 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1300 18.9442 -1.0030 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5334 16.1906 -1.1950 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2694 20.8403 -0.6832 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2066 23.2651 1.2858 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5309 24.3830 -0.0853 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0746 21.4973 0.9963 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6031 21.9739 -2.0593 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7321 23.7390 -1.7526 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6668 20.0963 2.7188 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.8568 21.1680 -4.1526 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.4016 11.1808 -2.5143 N 0 0 3 0 0 0 0 0 0 0 0 0 3.7549 10.3180 -2.9302 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0721 8.3699 -3.1817 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2163 18.6251 -0.5274 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3524 7.4688 -3.6163 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1815 5.2905 -4.9679 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5151 3.3331 -5.1025 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4413 2.7820 -4.7093 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1075 4.7394 -4.5747 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6568 5.5986 -3.8578 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9659 2.4741 -5.8194 N 0 0 0 0 0 0 0 0 0 0 0 0 3.2703 0.6038 -6.0609 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6860 17.6031 -0.4371 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5769 15.9358 -0.7166 N 0 0 0 0 0 0 0 0 0 0 0 0 13.2691 18.3442 -0.0515 N 0 0 3 0 0 0 0 0 0 0 0 0 13.4160 20.1512 0.0936 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4312 20.8745 1.4006 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5733 22.6593 1.5405 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7066 23.7259 0.3810 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6949 23.0099 -0.9218 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5532 21.2261 -1.0735 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7071 16.2488 -2.1846 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3716 18.9872 -1.4664 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0566 23.7753 2.5855 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6329 25.7642 0.1477 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9900 24.6181 -2.8170 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4653 10.5070 -2.4386 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8373 10.5140 -1.8681 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2217 10.8677 -4.1229 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9898 8.1740 -4.2440 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6054 7.8203 -1.9892 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2976 19.8664 -0.3192 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4346 7.6649 -2.5542 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8191 8.0186 -4.8090 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3149 5.9256 -4.4015 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9396 5.8190 -6.2607 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6226 3.0998 -5.9558 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7918 2.8109 -3.8142 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6831 2.2535 -3.4166 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3078 2.1470 -5.2758 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8308 5.2617 -5.8630 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.9727 -3.7215 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5819 0.0107 -4.8119 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1035 0.0000 -6.5927 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3515 0.4130 -6.9573 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6237 15.2331 -0.7563 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2828 17.6133 0.1195 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1080 20.0422 2.3070 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3621 23.2225 2.5569 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8199 25.1213 0.4934 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0197 23.8466 -1.8255 H 0 0 0 0 0 0 0 0 0 0 0 0 11.7675 20.6676 -2.0948 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 31 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 32 64 1 0 0 0 0 33 34 1 0 0 0 0 33 65 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 66 1 0 0 0 0 36 37 2 0 0 0 0 36 67 1 0 0 0 0 37 38 1 0 0 0 0 37 68 1 0 0 0 0 38 39 2 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 M END > (379) 378 > (379) C28H31Cl2N9 > (379) 564.5192 > (379) FGFR-P378 > (379) 6-arylpyrido[2,3-d]pyrimidine deriv. 80 > (379) FGFR-1 Tyrosine Kinase > (379) 2800 > (379) BINDDB > (379) <2007 > (379) P > (379) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 81 csChFnd70/04170815452D 78 81 0 0 0 0 0 0 0 0999 V2000 4.2142 15.9585 0.7685 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6678 13.3346 0.6200 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2027 14.2454 0.7595 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2096 14.0742 0.4831 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8192 16.8199 0.6267 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3561 15.8087 0.4799 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9392 18.6424 0.6257 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0471 18.2930 0.3384 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5757 19.3808 0.4796 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9008 16.5862 0.3423 N 0 0 0 0 0 0 0 0 0 0 0 0 7.7798 21.2974 0.4709 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2090 23.9804 2.0117 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1617 24.8787 0.4545 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0193 22.1947 2.0286 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7405 22.2102 -1.0957 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9319 23.9958 -1.0951 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0778 21.0696 3.9842 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.4524 21.1043 -3.0419 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.5699 11.5404 0.6190 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8779 10.6790 0.7695 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1329 8.7064 0.7352 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6820 19.0369 0.1925 N 0 0 3 0 0 0 0 0 0 0 0 0 2.3658 7.8067 0.8925 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7998 5.4006 -0.5454 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1009 3.4351 -0.4709 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.0432 0.7718 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9353 5.0087 0.6973 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6105 5.9130 0.8595 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4256 2.5308 -0.6332 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6703 0.6372 -0.6662 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1319 17.9933 0.0536 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9658 16.3077 0.0594 N 0 0 0 0 0 0 0 0 0 0 0 0 13.4867 15.1999 -0.2360 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6631 13.9027 1.2616 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2643 14.2107 -1.9473 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7535 18.7312 -0.0913 N 0 0 3 0 0 0 0 0 0 0 0 0 14.0830 21.1309 1.9685 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9566 20.6196 0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6133 21.1811 -0.8963 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0170 16.6841 0.8767 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7911 19.4432 0.7351 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3946 24.6766 3.2167 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3111 26.2748 0.4480 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9018 24.7039 -2.3072 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6215 10.8518 0.5186 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2635 11.0547 1.9901 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0519 11.0674 -0.3144 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7473 8.3307 -0.4852 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9588 8.3180 1.8193 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8055 20.2919 0.1881 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7514 8.1825 2.1130 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5399 8.1952 -0.1915 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0362 6.0747 -0.3874 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2297 5.7445 -1.7964 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9527 3.0467 -1.5348 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7035 3.0956 0.7659 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8065 2.6993 2.0227 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.3692 0.6138 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3327 5.3482 -0.5395 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0835 5.3972 1.7611 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2969 0.2209 0.5349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4104 0.0000 -0.7869 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4854 0.2854 -1.7708 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6511 16.0045 -0.3034 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7947 13.0785 1.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8216 14.6074 2.4809 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4985 13.0981 1.3291 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0266 15.1316 -2.9977 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4424 13.4732 -2.2232 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1651 13.3226 -1.8401 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7629 18.0014 -0.2871 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1218 22.5433 2.0793 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9540 20.6334 2.6655 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2633 20.5807 2.5272 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8370 21.2604 -0.5366 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5232 20.8167 -2.2629 H 0 0 0 0 0 0 0 0 0 0 0 0 15.7645 22.5862 -0.7910 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7329 20.5403 -0.3096 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 31 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 2 0 0 0 0 31 36 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 35 1 0 0 0 0 33 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 35 68 1 0 0 0 0 35 69 1 0 0 0 0 35 70 1 0 0 0 0 36 38 1 0 0 0 0 36 71 1 0 0 0 0 37 38 1 0 0 0 0 37 72 1 0 0 0 0 37 73 1 0 0 0 0 37 74 1 0 0 0 0 38 39 1 0 0 0 0 38 75 1 0 0 0 0 39 76 1 0 0 0 0 39 77 1 0 0 0 0 39 78 1 0 0 0 0 M END > (380) 379 > (380) C28H39Cl2N9 > (380) 572.5824 > (380) FGFR-P379 > (380) 6-arylpyrido[2,3-d]pyrimidine deriv. 81 > (380) FGFR-1 Tyrosine Kinase > (380) 2500 > (380) BINDDB > (380) <2007 > (380) P > (380) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 82 csChFnd70/04170815452D 71 74 0 0 0 0 0 0 0 0999 V2000 3.2090 16.0513 0.3214 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8926 13.5759 0.1697 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3502 14.3483 0.2630 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3641 14.4501 0.1298 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7327 17.0523 0.2830 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3557 16.1868 0.1831 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6901 18.8736 0.3398 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8205 18.8076 0.1955 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2566 19.7553 0.2952 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8268 17.0988 0.1438 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2892 21.6778 0.3511 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4055 24.3311 1.9838 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3497 25.2704 0.4554 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3754 22.5396 1.9403 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2415 22.6327 -1.1858 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2723 24.4237 -1.1250 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4440 21.3628 3.8600 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.1443 21.5721 -3.1709 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9549 11.7847 0.1124 N 0 0 3 0 0 0 0 0 0 0 0 0 3.3444 10.7757 0.1544 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7745 8.8391 0.0759 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3853 19.6948 0.1506 N 0 0 3 0 0 0 0 0 0 0 0 0 2.0925 7.7854 0.1199 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7970 5.5673 -1.3115 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2673 3.6381 -1.2792 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4000 2.9573 -0.1931 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9297 4.8865 -0.2254 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5054 5.9261 0.0445 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6917 2.5987 -1.5493 N 0 0 0 0 0 0 0 0 0 0 0 0 3.1046 0.7392 -1.6245 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8902 18.8091 0.0550 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4111 19.6714 0.0113 N 0 0 3 0 0 0 0 0 0 0 0 0 14.1878 17.5609 -1.5570 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5675 19.9901 0.0877 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8701 16.5888 -0.0110 S 0 0 0 0 0 0 0 0 0 0 0 0 14.0504 18.7100 0.0559 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1079 17.5752 1.6838 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9506 16.6640 0.3912 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4739 19.5656 0.4155 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4722 24.9998 3.2135 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3740 26.6711 0.4960 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2354 25.1644 -2.3141 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0652 11.1955 0.0441 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6444 11.0551 1.3511 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5399 11.1253 -0.9550 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4747 8.5598 -1.1208 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5790 8.4895 1.1854 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3968 20.9529 0.1880 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3923 8.0647 1.3166 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2879 8.1350 -0.9895 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9576 6.3400 -1.0741 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2584 5.9005 -2.5762 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1971 3.3618 -2.3087 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8385 3.3126 -0.0270 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9388 2.6241 1.0715 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2394 2.1848 -0.4305 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3585 5.2120 -1.4776 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.1629 0.8040 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7081 0.3407 -0.4091 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9156 0.0000 -1.8253 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9964 0.4973 -2.6954 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4202 20.9286 -0.0497 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2617 18.3752 -2.7112 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3513 16.7616 -1.4688 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0483 16.7272 -1.6404 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4698 20.8089 1.2368 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7873 19.2749 0.1209 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5265 20.7986 -1.0720 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9671 16.7399 1.7169 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2757 16.7776 1.6615 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1219 18.3995 2.8331 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 38 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 39 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 40 1 0 0 0 0 13 16 1 0 0 0 0 13 41 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 42 1 0 0 0 0 19 20 1 0 0 0 0 19 43 1 0 0 0 0 20 21 1 0 0 0 0 20 44 1 0 0 0 0 20 45 1 0 0 0 0 21 23 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 22 31 1 0 0 0 0 22 48 1 0 0 0 0 23 28 1 0 0 0 0 23 49 1 0 0 0 0 23 50 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 25 29 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 28 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 29 30 1 0 0 0 0 30 59 1 0 0 0 0 30 60 1 0 0 0 0 30 61 1 0 0 0 0 31 35 2 0 0 0 0 31 32 1 0 0 0 0 32 36 1 0 0 0 0 32 62 1 0 0 0 0 33 36 1 0 0 0 0 33 63 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 34 36 1 0 0 0 0 34 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 36 37 1 0 0 0 0 37 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 M END > (381) 380 > (381) C26H34Cl2N8S > (381) 561.5742 > (381) FGFR-P380 > (381) 6-arylpyrido[2,3-d]pyrimidine deriv. 82 > (381) FGFR-1 Tyrosine Kinase > (381) 100 > (381) BINDDB > (381) <2007 > (381) P > (381) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 83 csChFnd70/04170815452D 69 73 0 0 0 0 0 0 0 0999 V2000 3.5425 15.0893 -2.6295 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1489 12.5876 -3.0372 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6457 13.4416 -3.0818 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6171 13.3221 -2.5440 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0647 15.9419 -2.0921 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6453 14.9925 -2.0599 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0612 17.6964 -1.5907 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1438 17.4071 -1.0807 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6229 18.4312 -1.0802 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1140 15.7634 -1.5569 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6959 20.2779 -0.5382 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5148 22.4496 1.6959 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8322 23.7285 0.4743 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4452 20.7269 1.1993 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0229 21.5731 -1.7625 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0892 23.2912 -1.2494 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0460 19.1237 2.7344 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3466 21.0267 -3.9264 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.1725 10.8606 -3.5268 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5644 10.0065 -4.0804 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9472 8.1132 -4.5488 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7042 18.1476 -0.5693 N 0 0 3 0 0 0 0 0 0 0 0 0 2.2678 7.2211 -5.1269 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1905 5.2714 -6.6758 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5878 3.3556 -7.0287 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5282 2.6752 -6.7785 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1310 4.5910 -6.4256 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6354 5.4033 -5.5764 N 0 0 0 0 0 0 0 0 0 0 0 0 3.0833 2.5432 -7.8779 N 0 0 0 0 0 0 0 0 0 0 0 0 3.4508 0.7253 -8.3275 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1683 17.1876 -0.5632 C 0 0 0 0 0 0 0 0 0 0 0 0 11.1015 15.0538 -1.1868 S 0 0 0 0 0 0 0 0 0 0 0 0 12.6851 17.9073 -0.0662 N 0 0 3 0 0 0 0 0 0 0 0 0 14.1814 16.8832 0.0505 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5910 15.7266 -1.2723 C 0 0 0 0 0 0 0 0 0 0 0 0 16.0698 14.7179 -1.1533 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1419 14.8579 0.2812 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7379 16.0083 1.6006 C 0 0 0 0 0 0 0 0 0 0 0 0 15.2649 17.0261 1.4860 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3169 15.7707 -2.6763 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8775 18.4495 -1.6033 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3214 22.7990 3.0408 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8849 25.0738 0.8690 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3418 24.2954 -2.1961 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2537 10.2140 -3.5039 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6198 10.0503 -3.0267 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0402 10.6759 -5.2127 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8921 8.0693 -5.6025 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4717 7.4437 -3.4165 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7421 19.3567 -0.2161 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3232 7.2650 -4.0731 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7436 7.8907 -6.2591 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2902 5.8673 -6.0121 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9598 5.9398 -7.9026 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7186 3.2557 -7.8750 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8532 2.6949 -5.8049 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7589 2.0066 -5.5518 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4285 2.0791 -7.4422 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8656 5.2516 -7.6496 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.6909 -5.5794 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7539 0.0000 -7.1498 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3162 0.1555 -8.9540 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5551 0.6720 -9.2122 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7388 19.1354 0.2104 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7536 15.6159 -2.3925 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3890 13.8181 -2.1815 H 0 0 0 0 0 0 0 0 0 0 0 0 18.2971 14.0670 0.3716 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5778 16.1142 2.7195 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9531 17.9284 2.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 5 1 0 0 0 0 1 40 1 0 0 0 0 2 3 1 0 0 0 0 2 4 2 0 0 0 0 2 19 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 5 6 2 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 41 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 22 1 0 0 0 0 9 11 1 0 0 0 0 11 14 2 0 0 0 0 11 15 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 42 1 0 0 0 0 13 16 1 0 0 0 0 13 43 1 0 0 0 0 14 17 1 0 0 0 0 15 16 2 0 0 0 0 15 18 1 0 0 0 0 16 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 20 21 1 0 0 0 0 20 46 1 0 0 0 0 20 47 1 0 0 0 0 21 23 1 0 0 0 0 21 48 1 0 0 0 0 21 49 1 0 0 0 0 22 31 1 0 0 0 0 22 50 1 0 0 0 0 23 28 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 29 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 27 28 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 29 30 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 30 63 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 64 1 0 0 0 0 34 35 2 0 0 0 0 34 39 1 0 0 0 0 35 36 1 0 0 0 0 35 65 1 0 0 0 0 36 37 2 0 0 0 0 36 66 1 0 0 0 0 37 38 1 0 0 0 0 37 67 1 0 0 0 0 38 39 2 0 0 0 0 38 68 1 0 0 0 0 39 69 1 0 0 0 0 M END > (382) 381 > (382) C28H30Cl2N8S > (382) 581.5646 > (382) FGFR-P381 > (382) 6-arylpyrido[2,3-d]pyrimidine deriv. 83 > (382) FGFR-1 Tyrosine Kinase > (382) 320 > (382) BINDDB > (382) <2007 > (382) P > (382) TRAIN $$$$ 1,6-naphthyridin 25 csChFnd70/04170815452D 86 89 0 0 0 0 0 0 0 0999 V2000 1.2247 19.3017 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7178 16.6882 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3199 17.4938 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7861 20.2376 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3839 19.3153 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8122 22.0633 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9451 21.8810 -0.0204 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4114 22.8850 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2478 17.5964 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8917 20.1724 -0.0291 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5124 24.8077 0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6411 27.5680 -1.1672 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5436 25.7716 -1.1781 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5709 25.6550 1.2058 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6624 27.4518 1.2096 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7019 28.4070 0.0226 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6970 28.5088 -2.3237 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8597 30.3554 -2.2394 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6939 28.2791 2.3782 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7262 30.1331 2.3092 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6387 14.8849 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2428 13.8627 -0.0460 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7946 11.9272 -0.0521 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4700 10.8596 -0.0738 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0219 8.9240 -0.0799 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5442 22.7135 -0.0325 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0201 21.7733 -0.0528 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9511 20.1960 -0.0608 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5723 22.5813 -0.0647 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2150 20.4224 -1.7158 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1766 21.5592 -0.0869 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7416 22.7832 -0.0965 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2488 20.4047 1.5283 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6970 7.8564 -0.1015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9236 5.6031 1.1891 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4391 3.6792 1.0710 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3402 3.0106 0.0634 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8246 4.9345 0.1814 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2667 5.9980 -0.1074 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9969 2.6156 1.3599 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5666 0.7573 1.3539 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 19.9845 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5005 16.7371 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6206 22.8025 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7179 25.1191 -2.1050 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3186 24.9120 2.1307 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7755 29.8074 0.0283 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0402 30.9469 -3.2304 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4543 30.8069 -0.9607 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2087 30.7208 -2.4630 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5981 30.6274 3.3086 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1834 30.5499 1.0360 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4219 30.6363 2.5299 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5215 14.3036 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9884 14.1780 -1.2069 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0103 14.1655 1.1041 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0493 11.6119 1.1090 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0273 11.6242 -1.2021 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2154 11.1748 -1.2348 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2374 11.1625 1.0763 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2763 8.6087 1.0812 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2544 8.6212 -1.2299 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5992 23.9717 -0.0262 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6274 23.8396 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1636 21.2448 -2.8665 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4087 19.6620 -1.7322 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1002 19.5505 -1.7089 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7142 23.5930 1.0638 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9351 22.0228 -0.1130 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6902 23.6056 -1.2472 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1339 19.5328 1.5352 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4424 19.6443 1.5119 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2214 21.2147 2.6888 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4426 8.1718 -1.2626 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4644 8.1593 1.0485 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7775 6.3949 0.9380 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4193 5.8865 2.4842 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4701 3.3749 2.0569 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9103 3.4034 -0.2126 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8443 2.7271 -1.2316 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4861 2.2189 0.3144 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3533 5.2103 1.4650 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7936 5.2389 -0.8043 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0036 0.4073 0.1035 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7425 0.0000 1.5706 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6343 0.4856 2.3837 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 42 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 43 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 44 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 26 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 45 1 0 0 0 0 14 15 1 0 0 0 0 14 46 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 47 1 0 0 0 0 17 18 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 18 50 1 0 0 0 0 19 20 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 20 53 1 0 0 0 0 21 22 1 0 0 0 0 21 54 1 0 0 0 0 22 23 1 0 0 0 0 22 55 1 0 0 0 0 22 56 1 0 0 0 0 23 24 1 0 0 0 0 23 57 1 0 0 0 0 23 58 1 0 0 0 0 24 25 1 0 0 0 0 24 59 1 0 0 0 0 24 60 1 0 0 0 0 25 34 1 0 0 0 0 25 61 1 0 0 0 0 25 62 1 0 0 0 0 26 27 1 0 0 0 0 26 63 1 0 0 0 0 27 28 2 0 0 0 0 27 29 1 0 0 0 0 29 31 1 0 0 0 0 29 64 1 0 0 0 0 30 31 1 0 0 0 0 30 65 1 0 0 0 0 30 66 1 0 0 0 0 30 67 1 0 0 0 0 31 32 1 0 0 0 0 31 33 1 0 0 0 0 32 68 1 0 0 0 0 32 69 1 0 0 0 0 32 70 1 0 0 0 0 33 71 1 0 0 0 0 33 72 1 0 0 0 0 33 73 1 0 0 0 0 34 39 1 0 0 0 0 34 74 1 0 0 0 0 34 75 1 0 0 0 0 35 39 1 0 0 0 0 35 36 1 0 0 0 0 35 76 1 0 0 0 0 35 77 1 0 0 0 0 36 40 1 0 0 0 0 36 78 1 0 0 0 0 36 79 1 0 0 0 0 37 40 1 0 0 0 0 37 38 1 0 0 0 0 37 80 1 0 0 0 0 37 81 1 0 0 0 0 38 39 1 0 0 0 0 38 82 1 0 0 0 0 38 83 1 0 0 0 0 40 41 1 0 0 0 0 41 84 1 0 0 0 0 41 85 1 0 0 0 0 41 86 1 0 0 0 0 M END > (40) 38 > (40) C31H45N7O3 > (40) 563.7416 > (40) FGFR-P38 > (40) 1,6-naphthyridine 25 > (40) FGFR-1 Tyrosine Kinase > (40) 70 > (40) BINDDB > (40) <2007 > (40) P > (40) TRAIN $$$$ 1,6-naphthyridin 26 csChFnd70/04170815452D 83 85 0 0 0 0 0 0 0 0999 V2000 1.2745 16.0407 0.5318 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0314 13.5866 0.2940 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5077 14.5597 -0.0631 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6959 17.1398 0.1796 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3638 16.3862 -0.1277 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5145 18.9664 0.1220 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6002 19.1133 -0.5271 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9859 19.9553 -0.2355 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4904 14.3395 0.5751 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7415 17.4009 -0.4678 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8665 21.8867 -0.3120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4684 24.4864 -1.3884 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5761 22.6814 -1.3197 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0400 22.9110 0.6293 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9250 24.7152 0.5547 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6434 25.5023 -0.4556 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2106 25.2626 -2.3713 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1752 27.1286 -2.3826 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0686 25.7152 1.4729 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8748 27.5664 1.3362 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1585 11.7767 0.3613 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8439 10.9240 0.0554 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6247 8.9432 0.2035 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3848 8.0525 -0.1160 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1656 6.0719 0.0321 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0701 20.1128 -0.8855 N 0 0 3 0 0 0 0 0 0 0 0 0 8.6204 19.3284 -1.1683 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7317 17.7456 -1.1095 O 0 0 0 0 0 0 0 0 0 0 0 0 10.0473 20.2988 -1.5162 N 0 0 3 0 0 0 0 0 0 0 0 0 11.5835 18.2249 -3.3982 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7324 19.4463 -1.8237 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1245 20.8334 -2.1860 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2491 18.3902 -0.2078 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9257 5.1812 -0.2873 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3594 2.3903 -2.7408 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2932 2.3665 -0.7437 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7153 3.2795 -0.1452 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2648 2.7697 1.6488 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5589 0.9003 1.6527 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.5945 0.7739 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7486 13.9278 -0.2876 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2647 19.5796 0.3494 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6613 21.8914 -2.0465 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0378 22.2990 1.4165 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5566 26.9091 -0.5115 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1117 27.5780 -3.2155 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9747 27.6076 -1.0570 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4122 27.6237 -2.8840 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8671 28.2073 2.1307 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0280 27.9605 -0.0232 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5816 27.9435 1.7968 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1313 11.0785 0.6107 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3128 11.2534 -1.2478 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7849 11.3711 1.0255 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1557 8.6138 1.5067 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6835 8.4961 -0.7667 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8538 8.3821 -1.4192 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3260 8.4997 0.8542 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6967 5.7423 1.3352 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2246 5.6247 -0.9380 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9813 21.3758 -0.9324 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9585 21.5618 -1.5633 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2155 18.9771 -4.5494 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8374 17.5905 -3.6269 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5918 17.2365 -3.1401 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2305 21.7036 -1.0642 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3783 20.1990 -2.4147 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7564 21.5857 -3.3370 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2574 17.4020 0.0503 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5030 17.7558 -0.4365 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3552 19.2603 0.9139 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3947 5.5106 -1.5906 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8669 5.6283 0.6827 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4871 1.6449 -3.1871 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1693 1.8083 -3.2621 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4688 3.7348 -3.1958 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2639 1.0187 -0.2859 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4458 3.0197 -0.2228 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4270 2.8398 2.4681 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2713 3.6533 2.1578 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0894 0.5730 2.9563 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4866 0.7959 0.7221 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5978 0.0000 1.2826 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 40 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 41 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 42 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 26 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 17 1 0 0 0 0 13 43 1 0 0 0 0 14 15 1 0 0 0 0 14 44 1 0 0 0 0 15 16 2 0 0 0 0 15 19 1 0 0 0 0 16 45 1 0 0 0 0 17 18 1 0 0 0 0 18 46 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 19 20 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 20 51 1 0 0 0 0 21 22 1 0 0 0 0 21 52 1 0 0 0 0 22 23 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 24 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 25 1 0 0 0 0 24 57 1 0 0 0 0 24 58 1 0 0 0 0 25 34 1 0 0 0 0 25 59 1 0 0 0 0 25 60 1 0 0 0 0 26 27 1 0 0 0 0 26 61 1 0 0 0 0 27 28 2 0 0 0 0 27 29 1 0 0 0 0 29 31 1 0 0 0 0 29 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 30 64 1 0 0 0 0 30 65 1 0 0 0 0 31 32 1 0 0 0 0 31 33 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 32 68 1 0 0 0 0 33 69 1 0 0 0 0 33 70 1 0 0 0 0 33 71 1 0 0 0 0 34 37 1 0 0 0 0 34 72 1 0 0 0 0 34 73 1 0 0 0 0 35 36 1 0 0 0 0 35 74 1 0 0 0 0 35 75 1 0 0 0 0 35 76 1 0 0 0 0 36 37 1 0 0 0 0 36 77 1 0 0 0 0 36 78 1 0 0 0 0 37 38 1 0 0 0 0 38 39 1 0 0 0 0 38 79 1 0 0 0 0 38 80 1 0 0 0 0 39 81 1 0 0 0 0 39 82 1 0 0 0 0 39 83 1 0 0 0 0 M END > (41) 39 > (41) C30H44N6O3 > (41) 536.716 > (41) FGFR-P39 > (41) 1,6-naphthyridine 26 > (41) FGFR-1 Tyrosine Kinase > (41) 28 > (41) BINDDB > (41) <2007 > (41) P > (41) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7b csChFnd70/04170815452D 35 37 0 0 0 0 0 0 0 0999 V2000 1.2121 6.7244 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6910 4.1457 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2753 4.9632 -0.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7525 7.6519 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3247 6.7470 -0.0177 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7523 9.4694 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2875 10.3246 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8946 9.3472 -0.0212 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2653 10.1015 -0.0301 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2350 5.0351 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8630 7.6168 -0.0283 N 0 0 3 0 0 0 0 0 0 0 0 0 7.4795 6.6540 -0.0483 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3237 12.2272 0.0072 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3897 14.8938 1.5591 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3561 13.1203 1.5608 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3331 13.1335 -1.5389 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3668 14.9070 -1.5226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3920 15.7847 0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3531 12.0046 3.4912 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3031 12.0344 -3.4786 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6268 2.3652 -0.0257 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2213 1.3663 -0.0462 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.3986 0.0329 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4497 4.2252 -0.0416 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5564 10.1719 0.0254 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8677 6.4214 -1.3731 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4717 7.3941 0.6057 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3017 5.4300 0.6076 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4142 15.5867 2.7605 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3742 15.6100 -2.7182 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4183 17.1716 0.0276 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5262 1.7814 -0.0186 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9564 1.6845 -1.1945 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9778 1.6713 1.0915 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9160 0.0000 -0.0512 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 23 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 24 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 25 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 26 1 0 0 0 0 12 27 1 0 0 0 0 12 28 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 29 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 30 1 0 0 0 0 18 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 M END > (5) 3 > (5) C16H13Cl2N3O > (5) 334.2042 > (5) FGFR-P3 > (5) 1,6-naphthyridin-2(1H)-one deriv. 7b > (5) FGFR-1 Tyrosine Kinase > (5) 210 > (5) BINDDB > (5) <2007 > (5) P > (5) TRAIN $$$$ 1,6-naphthyridin 27 csChFnd70/04170815452D 56 59 0 0 0 0 0 0 0 0999 V2000 1.2247 16.2969 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7176 13.6835 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3196 14.4896 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7854 17.2327 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3830 16.3109 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8108 19.0590 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9441 18.8773 -0.0204 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4088 19.8813 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2478 14.5916 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8910 17.1679 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5087 21.8037 0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6604 24.4426 1.2018 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5722 22.6531 1.2008 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5453 22.7684 -1.1829 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6439 24.5574 -1.1696 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6962 25.3935 0.0218 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6389 11.8805 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2431 10.8585 -0.0460 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7952 8.9231 -0.0521 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4705 7.8557 -0.0738 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5372 19.7075 -0.0317 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6975 5.6023 1.2169 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2133 3.6787 1.0987 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1142 3.0105 0.0911 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5984 4.9342 0.2092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0405 5.9974 -0.0796 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7712 2.6154 1.3876 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3410 0.7571 1.3817 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9797 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5002 13.7331 -0.0425 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6189 19.7975 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4836 25.1022 2.1259 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3252 21.9121 2.1229 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7237 22.1170 -2.1140 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8985 25.3062 -2.0916 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7690 26.7940 0.0277 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5218 11.2989 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9883 11.1740 -1.2070 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0103 11.1615 1.1040 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0499 8.6077 1.1090 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0279 8.6201 -1.2021 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2158 8.1711 -1.2348 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2378 8.1588 1.0763 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5996 19.0312 -0.0453 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5917 20.9658 -0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5514 6.3939 0.9658 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1932 5.8858 2.5118 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2445 3.3742 2.0845 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6846 3.4028 -0.1848 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6184 2.7271 -1.2038 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2603 2.2190 0.3421 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1271 5.2101 1.4927 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5672 5.2386 -0.7765 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7783 0.4071 0.1313 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5172 0.0000 1.5982 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4090 0.4854 2.4113 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 29 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 30 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 31 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 32 1 0 0 0 0 13 33 1 0 0 0 0 14 15 1 0 0 0 0 14 34 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 17 37 1 0 0 0 0 18 19 1 0 0 0 0 18 38 1 0 0 0 0 18 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 19 41 1 0 0 0 0 20 26 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 22 26 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 27 1 0 0 0 0 23 48 1 0 0 0 0 23 49 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 25 26 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 27 28 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 28 56 1 0 0 0 0 M END > (42) 40 > (42) C22H28N6 > (42) 376.5034 > (42) FGFR-P40 > (42) 1,6-naphthyridine 27 > (42) FGFR-1 Tyrosine Kinase > (42) 2200 > (42) BINDDB > (42) <2007 > (42) P > (42) TRAIN $$$$ 1,6-naphthyridin 28 csChFnd70/04170815452D 72 75 0 0 0 0 0 0 0 0999 V2000 1.2227 16.2719 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7133 13.6628 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3127 14.4672 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 17.2063 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3766 16.2855 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0290 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9353 18.8469 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4041 19.8493 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.5696 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8819 17.1413 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5050 21.7687 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6372 24.5191 -1.1626 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5380 22.7328 -1.1761 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5616 22.6165 1.2037 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6505 24.4033 1.2050 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6932 25.3530 0.0228 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6343 11.8625 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2358 10.8420 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7883 8.9097 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4609 7.8438 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6901 5.5938 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2064 3.6732 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1028 3.0061 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5864 4.9267 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0313 5.9886 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7615 2.6112 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3319 0.7560 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5318 19.6780 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0052 18.7393 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9364 17.1647 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5549 19.5460 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1565 18.5256 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1959 17.3899 -1.7079 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7189 19.7475 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2274 17.3737 1.5307 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9537 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4913 13.7116 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6177 19.7670 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8885 25.2673 -2.0791 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7131 22.0831 -2.1022 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3090 21.8765 2.1278 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4687 25.0615 2.1311 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7663 26.7511 0.0289 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5189 11.2821 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9803 11.1572 -1.2053 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0017 11.1440 1.1019 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0440 8.5946 1.1057 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0224 8.6076 -1.2017 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2054 8.1590 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2268 8.1459 1.0735 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5459 6.3844 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1848 5.8764 2.5056 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2388 3.3691 2.0777 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6788 3.3983 -0.1878 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6081 2.7235 -1.2048 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2469 2.2155 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1141 5.2016 1.4885 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5540 5.2308 -0.7770 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7702 0.4071 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5059 0.0000 1.5917 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4010 0.4846 2.4033 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5866 20.9343 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6099 20.8023 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1454 18.2106 -2.8572 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3876 16.6308 -1.7234 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0829 16.5194 -1.7016 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6908 20.5566 1.0666 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9105 18.9883 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6683 20.5682 -1.2406 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1144 16.5032 1.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4191 16.6146 1.5153 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1993 18.1828 2.6889 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 38 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 28 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 39 1 0 0 0 0 13 40 1 0 0 0 0 14 15 1 0 0 0 0 14 41 1 0 0 0 0 15 16 2 0 0 0 0 15 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 17 44 1 0 0 0 0 18 19 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 25 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 21 25 1 0 0 0 0 21 22 1 0 0 0 0 21 51 1 0 0 0 0 21 52 1 0 0 0 0 22 26 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 26 1 0 0 0 0 23 24 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 25 1 0 0 0 0 24 57 1 0 0 0 0 24 58 1 0 0 0 0 26 27 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 27 61 1 0 0 0 0 28 29 1 0 0 0 0 28 62 1 0 0 0 0 29 30 2 0 0 0 0 29 31 1 0 0 0 0 31 32 1 0 0 0 0 31 63 1 0 0 0 0 32 33 1 0 0 0 0 32 34 1 0 0 0 0 32 35 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 33 66 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 34 69 1 0 0 0 0 35 70 1 0 0 0 0 35 71 1 0 0 0 0 35 72 1 0 0 0 0 M END > (43) 41 > (43) C27H37N7O > (43) 475.6356 > (43) FGFR-P41 > (43) 1,6-naphthyridine 28 > (43) FGFR-1 Tyrosine Kinase > (43) 190 > (43) BINDDB > (43) <2007 > (43) P > (43) TRAIN $$$$ tetrahydroindole deriv. 4c csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.8277 4.3514 -0.3650 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8164 2.7908 -0.7555 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8531 2.2243 -1.8546 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9065 3.2067 -2.5709 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8842 5.3511 -1.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9361 4.7817 -2.1928 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1986 7.0403 -0.9341 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4764 7.3515 -2.0291 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8571 6.0018 -2.7262 N 0 0 3 0 0 0 0 0 0 0 0 0 7.0846 8.6124 -2.2644 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4508 8.0965 0.0241 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0166 9.6341 0.1517 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1220 10.9741 0.2957 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6291 11.6505 0.2978 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1515 12.2219 0.3863 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7593 13.9273 0.5555 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0732 12.6550 0.3553 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5962 14.3464 0.0274 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2301 14.7940 1.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5613 10.0812 0.1631 N 0 0 3 0 0 0 0 0 0 0 0 0 3.1333 0.0000 0.0337 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0654 2.2204 1.5871 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4812 1.5180 0.1462 S 0 0 0 0 0 0 0 0 0 0 0 0 0.8832 1.5062 -0.9354 N 0 0 0 0 0 0 0 0 0 0 0 0 3.0160 4.7951 0.4884 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8378 1.0020 -2.1540 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7092 2.7509 -3.4265 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6712 5.8934 -3.5029 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4330 7.7445 0.6753 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8654 11.0356 0.3305 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3687 14.3894 -0.5613 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8428 14.0716 1.4230 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6015 12.5792 1.5081 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9029 12.2620 -0.5225 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5791 15.1162 0.2610 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2499 14.4600 -1.1895 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0323 16.0467 1.0125 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5008 14.4759 2.2838 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4498 9.3868 0.0853 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8303 2.1363 -1.8725 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.8693 -0.6320 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 25 1 0 0 0 0 2 3 2 0 0 0 0 2 23 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 6 2 0 0 0 0 4 27 1 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 28 1 0 0 0 0 11 12 1 0 0 0 0 11 29 1 0 0 0 0 12 13 2 0 0 0 0 12 20 1 0 0 0 0 13 15 1 0 0 0 0 13 30 1 0 0 0 0 14 20 1 0 0 0 0 14 17 1 0 0 0 0 14 15 2 0 0 0 0 15 16 1 0 0 0 0 16 19 1 0 0 0 0 16 31 1 0 0 0 0 16 32 1 0 0 0 0 17 18 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 18 19 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 39 1 0 0 0 0 21 23 2 0 0 0 0 22 23 2 0 0 0 0 23 24 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 M END > (422) 421 > (422) C17H17N3O3S > (422) 343.3996 > (422) FGFR-P421 > (422) Indolin-2-one deriv. 4c > (422) FGFR-1 Tyrosine Kinase > (422) 220 > (422) BINDDB > (422) <2007 > (422) P > (422) TRAIN $$$$ tetrahydroindole deriv. 4d csChFnd70/04170815452D 39 42 0 0 0 0 0 0 0 0999 V2000 2.0578 4.8171 -0.3696 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0448 3.2395 -0.7643 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1047 2.6719 -1.8654 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1595 3.6569 -2.5616 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1222 5.8068 -1.0738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1852 5.2338 -2.1779 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4409 7.4954 -0.9261 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7295 7.7990 -2.0092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1121 6.4473 -2.6990 N 0 0 3 0 0 0 0 0 0 0 0 0 5.3452 9.0563 -2.2405 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6889 8.5551 0.0238 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2564 10.0915 0.1506 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3636 11.4320 0.2947 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8705 12.1055 0.2947 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3940 12.6784 0.3839 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0040 14.3836 0.5526 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3150 13.1082 0.3511 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8397 14.7993 0.0226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4755 15.2486 1.0797 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8008 10.5368 0.1613 N 0 0 3 0 0 0 0 0 0 0 0 0 0.9186 2.1745 -0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.6698 0.9331 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9086 0.6523 -0.4060 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2401 5.2648 0.4754 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0945 1.4513 -2.1706 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9720 3.2056 -3.4096 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9337 6.3353 -3.4668 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6666 8.2067 0.6690 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1076 11.4948 0.3304 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6132 14.8454 -0.5637 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0884 14.5290 1.4203 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8433 13.0328 1.5033 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1438 12.7139 -0.5264 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8232 15.5680 0.2553 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4931 14.9126 -1.1937 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2788 16.5010 1.0079 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7466 14.9308 2.2789 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6882 9.8417 0.0831 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1493 0.0000 0.1108 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 5 2 0 0 0 0 1 24 1 0 0 0 0 2 3 2 0 0 0 0 2 21 1 0 0 0 0 3 4 1 0 0 0 0 3 25 1 0 0 0 0 4 6 2 0 0 0 0 4 26 1 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 9 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 27 1 0 0 0 0 11 12 1 0 0 0 0 11 28 1 0 0 0 0 12 13 2 0 0 0 0 12 20 1 0 0 0 0 13 15 1 0 0 0 0 13 29 1 0 0 0 0 14 20 1 0 0 0 0 14 17 1 0 0 0 0 14 15 2 0 0 0 0 15 16 1 0 0 0 0 16 19 1 0 0 0 0 16 30 1 0 0 0 0 16 31 1 0 0 0 0 17 18 1 0 0 0 0 17 32 1 0 0 0 0 17 33 1 0 0 0 0 18 19 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 20 38 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 39 1 0 0 0 0 M END > (423) 422 > (423) C18H16N2O3 > (423) 308.336 > (423) FGFR-P422 > (423) Indolin-2-one deriv. 4d > (423) FGFR-1 Tyrosine Kinase > (423) 310 > (423) BINDDB > (423) <2007 > (423) P > (423) TRAIN $$$$ Indolin-2-one deriv. 9a csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 5.9295 3.8034 -0.3137 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8654 2.0687 -0.6935 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0415 1.3583 -1.8286 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2872 2.3691 -2.5922 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3725 4.1186 -2.2261 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1795 4.8332 -1.0763 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5957 6.6878 -0.9551 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0775 6.9350 -2.1023 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4740 5.4041 -2.8025 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8182 8.2906 -2.3712 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7692 7.9202 0.0252 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4581 9.5950 0.1471 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5270 11.1124 0.2982 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1815 10.0247 0.1458 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5958 11.2800 0.3635 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9912 11.1820 2.2351 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0598 11.3497 2.3003 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2502 11.5292 0.9848 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2393 11.2996 3.8197 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3223 11.7547 0.2821 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7154 12.4479 0.3787 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3542 14.3481 0.5504 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9580 12.8041 0.3277 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5017 14.6862 -0.0516 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0170 15.2492 1.1156 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0093 4.3594 0.5675 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8967 1.2646 -0.1040 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9839 0.0000 -2.1187 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1973 1.8001 -3.4754 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4086 5.2203 -3.6098 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5956 7.6007 0.6981 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1329 9.2206 0.0615 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2146 12.5129 -0.1871 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0109 10.2385 -0.3721 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3724 9.9492 2.7857 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5762 12.2235 2.9706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 11.4125 3.7967 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9344 14.8628 -0.6854 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3546 14.5539 1.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5462 12.7074 1.5977 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8510 12.3294 -0.6446 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6201 15.4969 0.1934 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1185 14.8127 -1.3953 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8498 16.6391 1.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3111 14.8992 2.4419 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 26 1 0 0 0 0 2 3 2 0 0 0 0 2 27 1 0 0 0 0 3 4 1 0 0 0 0 3 28 1 0 0 0 0 4 5 2 0 0 0 0 4 29 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 30 1 0 0 0 0 11 12 1 0 0 0 0 11 31 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 32 1 0 0 0 0 15 16 1 0 0 0 0 15 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 16 36 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 37 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (429) 428 > (429) C20H20N2O3 > (429) 336.3896 > (429) FGFR-P428 > (429) Indolin-2-one deriv. 9a > (429) FGFR-1 Tyrosine Kinase > (429) 270 > (429) BINDDB > (429) <2007 > (429) P > (429) TRAIN $$$$ Indolin-2-one deriv. 9b csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 5.5964 3.5884 -0.2957 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5357 1.9512 -0.6540 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6456 1.2811 -1.7261 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8206 2.2353 -2.4459 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9007 3.8855 -2.1003 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7755 4.5596 -1.0154 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1681 6.3093 -0.9015 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5656 6.5428 -1.9840 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9401 5.0985 -2.6445 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2646 7.8216 -2.2373 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3881 7.4719 0.0229 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0378 9.0519 0.1378 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1592 10.4832 0.2797 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6635 9.4576 0.1368 N 0 0 3 0 0 0 0 0 0 0 0 0 4.3373 10.6414 0.3402 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7659 10.5487 2.1055 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9440 10.7067 2.1659 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1808 10.8760 0.9245 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1690 10.6594 3.5989 O 0 0 0 0 0 0 0 0 0 0 0 0 8.7960 11.0896 0.2652 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2800 11.7432 0.3556 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9391 13.5357 0.5172 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3389 12.0799 0.3082 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9084 13.8549 -0.0503 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5075 14.3860 1.0506 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9366 0.6225 0.3203 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.7285 4.1132 0.5356 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5913 0.0000 -2.0007 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6795 1.6987 -3.2789 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8217 4.9251 -3.4059 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2809 7.1705 0.6576 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5610 8.6992 0.0574 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9779 11.8041 -0.1794 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7860 9.6586 -0.3541 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1253 9.3859 2.6251 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3173 11.5313 2.7997 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 10.7660 3.5764 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5434 14.0210 -0.6486 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9958 13.7300 1.4250 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8935 11.9888 1.5064 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1816 11.6318 -0.6087 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9633 14.6200 0.1809 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5471 13.9738 -1.3179 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3495 15.6972 0.9647 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7845 14.0561 2.3021 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 27 1 0 0 0 0 2 3 2 0 0 0 0 2 26 1 0 0 0 0 3 4 1 0 0 0 0 3 28 1 0 0 0 0 4 5 2 0 0 0 0 4 29 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 30 1 0 0 0 0 11 12 1 0 0 0 0 11 31 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 32 1 0 0 0 0 15 16 1 0 0 0 0 15 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 16 36 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 37 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 24 25 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (430) 429 > (430) C20H19BrN2O3 > (430) 415.2857 > (430) FGFR-P429 > (430) Indolin-2-one deriv. 9b > (430) FGFR-1 Tyrosine Kinase > (430) 270 > (430) BINDDB > (430) <2007 > (430) P > (430) TRAIN $$$$ Indolin-2-one deriv. 9c csChFnd70/04170815452D 50 53 0 0 0 0 0 0 0 0999 V2000 5.9295 4.7543 -0.3137 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8654 3.0198 -0.6935 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0416 2.3093 -1.8286 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2873 3.3201 -2.5923 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3726 5.0695 -2.2261 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1796 5.7842 -1.0763 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5958 7.6388 -0.9551 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0776 7.8861 -2.1023 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4740 6.3550 -2.8025 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8183 9.2417 -2.3713 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7693 8.8712 0.0252 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4582 10.5460 0.1471 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5271 12.0634 0.2982 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1816 10.9756 0.1458 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5958 12.2311 0.3635 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9912 12.1330 2.2351 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0599 12.3007 2.3004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2502 12.4803 0.9848 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2393 12.2506 3.8197 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3223 12.7058 0.2821 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7155 13.3989 0.3787 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3543 15.2991 0.5504 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9581 13.7552 0.3277 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5017 15.6372 -0.0516 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0171 16.2001 1.1156 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9388 0.0000 0.2307 O 0 0 0 0 0 0 0 0 0 0 0 0 3.7810 2.5523 1.8102 O 0 0 0 0 0 0 0 0 0 0 0 0 4.2850 1.7078 0.2682 S 0 0 0 0 0 0 0 0 0 0 0 0 2.5823 1.7286 -1.0137 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0093 5.3104 0.5675 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9840 0.9509 -2.1188 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1974 2.7509 -3.4754 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4086 6.1712 -3.6098 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5956 8.5518 0.6981 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1329 10.1715 0.0615 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2146 13.4639 -0.1871 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0109 11.1894 -0.3721 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3724 10.9002 2.7858 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5762 13.1746 2.9706 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.3635 3.7967 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9345 15.8138 -0.6854 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3546 15.5049 1.5130 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5463 13.6584 1.5977 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8511 13.2805 -0.6446 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6202 16.4479 0.1934 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1185 15.7638 -1.3953 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8499 17.5901 1.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3111 15.8503 2.4420 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6047 2.3929 -2.0706 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5625 1.0767 -0.7077 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 30 1 0 0 0 0 2 3 2 0 0 0 0 2 28 1 0 0 0 0 3 4 1 0 0 0 0 3 31 1 0 0 0 0 4 5 2 0 0 0 0 4 32 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 33 1 0 0 0 0 11 12 1 0 0 0 0 11 34 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 35 1 0 0 0 0 15 16 1 0 0 0 0 15 36 1 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 16 38 1 0 0 0 0 16 39 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 40 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 28 2 0 0 0 0 27 28 2 0 0 0 0 28 29 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 M END > (431) 430 > (431) C20H21N3O5S > (431) 415.463 > (431) FGFR-P430 > (431) Indolin-2-one deriv. 9c > (431) FGFR-1 Tyrosine Kinase > (431) 200 > (431) BINDDB > (431) <2007 > (431) P > (431) TRAIN $$$$ Indolin-2-one deriv. 9d csChFnd70/04170815452D 48 51 0 0 0 0 0 0 0 0999 V2000 5.9281 5.2201 -0.3161 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8634 3.4662 -0.7015 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0569 2.7584 -1.8499 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2937 3.7778 -2.6018 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3723 5.5302 -2.2286 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1759 6.2442 -1.0768 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5934 8.0993 -0.9536 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0757 8.3439 -2.0998 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4692 6.8133 -2.8016 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8197 9.6979 -2.3670 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7673 9.3321 0.0263 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4581 11.0061 0.1493 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5286 12.5242 0.3004 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1818 11.4339 0.1492 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5976 12.6941 0.3645 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9918 12.5959 2.2354 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0606 12.7657 2.2995 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2521 12.9466 0.9837 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2392 12.7159 3.8185 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3243 13.1636 0.2862 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7184 13.8585 0.3820 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3591 15.7588 0.5542 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9612 14.2112 0.3336 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5072 16.0938 -0.0449 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0225 16.6578 1.1208 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5427 2.3631 0.0997 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5083 2.9802 1.0970 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4832 0.6707 -0.2743 O 0 0 0 0 0 0 0 0 0 0 0 0 5.0079 5.7768 0.5646 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0067 1.4016 -2.1479 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2083 3.2173 -3.4857 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4045 6.6296 -3.6078 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5928 9.0138 0.6980 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1323 10.6289 0.0651 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2181 13.9275 -0.1859 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0120 11.6535 -0.3720 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3713 11.3626 2.7858 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5774 13.6365 2.9719 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 12.8300 3.7946 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9406 16.2744 -0.6815 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3592 15.9654 1.5162 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5483 14.1130 1.6039 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8544 13.7361 -0.6384 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6263 16.9031 0.2014 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1251 16.2214 -1.3888 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8568 18.0480 1.0303 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3153 16.3070 2.4470 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5948 0.0000 0.2823 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 29 1 0 0 0 0 2 3 2 0 0 0 0 2 26 1 0 0 0 0 3 4 1 0 0 0 0 3 30 1 0 0 0 0 4 5 2 0 0 0 0 4 31 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 32 1 0 0 0 0 11 12 1 0 0 0 0 11 33 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 15 35 1 0 0 0 0 15 36 1 0 0 0 0 16 17 1 0 0 0 0 16 37 1 0 0 0 0 16 38 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 39 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 26 27 2 0 0 0 0 26 28 1 0 0 0 0 28 48 1 0 0 0 0 M END > (432) 431 > (432) C21H20N2O5 > (432) 380.3994 > (432) FGFR-P431 > (432) Indolin-2-one deriv. 9d > (432) FGFR-1 Tyrosine Kinase > (432) 220 > (432) BINDDB > (432) <2007 > (432) P > (432) TRAIN $$$$ Indolin-2-one deriv. 9e csChFnd70/04170815452D 49 52 0 0 0 0 0 0 0 0999 V2000 5.9475 6.4761 -0.3123 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8844 4.7419 -0.6892 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0648 4.0297 -1.8285 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3113 5.0483 -2.5947 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3901 6.7969 -2.2276 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1957 7.5077 -1.0765 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6072 9.3638 -0.9551 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0879 9.6153 -2.1032 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4875 8.0857 -2.8047 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8257 10.9726 -2.3710 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7780 10.5934 0.0253 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4629 12.2706 0.1474 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5279 13.7852 0.2985 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1849 12.7047 0.1460 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5961 13.9476 0.3636 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9919 13.8479 2.2352 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0600 14.0104 2.3004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2499 14.1878 0.9847 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2394 13.9580 3.8199 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3213 14.4356 0.2824 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7129 15.1243 0.3789 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3466 17.0234 0.5508 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9543 15.4892 0.3284 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4931 17.3702 -0.0506 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0068 17.9290 1.1160 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9961 2.3202 -2.1933 O 0 0 0 0 0 0 0 0 0 0 0 0 5.6808 1.3408 -1.3603 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0274 7.0320 0.5691 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9170 3.9375 -0.0980 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2234 4.4826 -3.4782 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4222 7.9046 -3.6124 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6055 10.2708 0.6986 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1383 11.9030 0.0614 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2116 15.1795 -0.1870 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0141 12.9046 -0.3721 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3762 12.6161 2.7856 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5739 14.8910 2.9707 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.0676 3.7967 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9253 17.5371 -0.6850 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3463 17.2264 1.5132 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5426 15.3937 1.5983 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8486 15.0170 -0.6440 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6094 18.1836 0.1949 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1097 17.4959 -1.3942 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8359 19.3185 1.0251 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3017 17.5797 2.4425 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8462 1.4231 0.0304 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4227 1.8524 -1.7128 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7700 0.0000 -1.7635 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 28 1 0 0 0 0 2 3 2 0 0 0 0 2 29 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 30 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 31 1 0 0 0 0 11 12 1 0 0 0 0 11 32 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 33 1 0 0 0 0 15 16 1 0 0 0 0 15 34 1 0 0 0 0 15 35 1 0 0 0 0 16 17 1 0 0 0 0 16 36 1 0 0 0 0 16 37 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 38 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 26 27 1 0 0 0 0 27 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 M END > (433) 432 > (433) C21H22N2O4 > (433) 366.4158 > (433) FGFR-P432 > (433) Indolin-2-one deriv. 9e > (433) FGFR-1 Tyrosine Kinase > (433) 1080 > (433) BINDDB > (433) <2007 > (433) P > (433) TRAIN $$$$ Indolin-2-one deriv. 9f csChFnd70/04170815452D 55 59 0 0 0 0 0 0 0 0999 V2000 6.0144 9.2128 -0.3123 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9525 7.4695 -0.6873 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1464 6.7499 -1.8389 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4034 7.7847 -2.6133 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4749 9.5422 -2.2427 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2692 10.2538 -1.0835 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6769 12.1220 -0.9615 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1667 12.3809 -2.1162 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5746 10.8439 -2.8237 N 0 0 3 0 0 0 0 0 0 0 0 0 9.9039 13.7500 -2.3851 O 0 0 0 0 0 0 0 0 0 0 0 0 6.8371 13.3574 0.0256 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5199 15.0467 0.1490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5735 16.5684 0.3009 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2517 15.4899 0.1486 N 0 0 3 0 0 0 0 0 0 0 0 0 4.6288 16.7254 0.3649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0195 16.6223 2.2479 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0748 16.7793 2.3120 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2598 16.9557 0.9875 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2480 16.7233 3.8406 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3826 17.2317 0.2868 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7611 17.9196 0.3833 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3860 19.8296 0.5565 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0224 18.2979 0.3339 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5516 20.1894 -0.0469 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0534 20.7463 1.1270 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0758 4.8723 -2.2387 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2686 4.1437 -3.3815 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1965 2.3956 -3.7490 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9433 1.3670 -2.9857 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7562 2.0832 -1.8505 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8208 3.8281 -1.4674 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0878 9.7723 0.5739 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9806 6.6596 -0.0901 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3236 7.2197 -3.5028 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5162 10.6657 -3.6362 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6576 13.0287 0.7024 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2141 14.6866 0.0635 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2382 17.9640 -0.1890 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0470 15.6740 -0.3763 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4100 15.3837 2.8019 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6012 17.6739 2.9891 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.8294 3.8164 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9614 20.3455 -0.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3780 20.0301 1.5245 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6144 18.2035 1.6123 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9245 17.8262 -0.6444 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6723 21.0119 0.2006 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1658 20.3149 -1.3993 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8768 22.1441 1.0360 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3504 20.3952 2.4620 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2469 4.9456 -3.9790 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1201 1.8297 -4.6343 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8912 0.0000 -3.2777 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7806 1.2741 -1.2584 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8973 4.3846 -0.5760 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 32 1 0 0 0 0 2 3 2 0 0 0 0 2 33 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 34 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 35 1 0 0 0 0 11 12 1 0 0 0 0 11 36 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 37 1 0 0 0 0 15 16 1 0 0 0 0 15 38 1 0 0 0 0 15 39 1 0 0 0 0 16 17 1 0 0 0 0 16 40 1 0 0 0 0 16 41 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 42 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 24 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 51 1 0 0 0 0 28 29 2 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 53 1 0 0 0 0 30 31 2 0 0 0 0 30 54 1 0 0 0 0 31 55 1 0 0 0 0 M END > (434) 433 > (434) C26H24N2O3 > (434) 412.4872 > (434) FGFR-P433 > (434) Indolin-2-one deriv. 9f > (434) FGFR-1 Tyrosine Kinase > (434) 1270 > (434) BINDDB > (434) <2007 > (434) P > (434) TRAIN $$$$ Indolin-2-one deriv. 9g csChFnd70/04170815452D 59 63 0 0 0 0 0 0 0 0999 V2000 5.9345 9.1450 0.0405 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9733 7.6145 -0.0118 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3133 6.8815 -0.2886 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6149 7.6884 -0.5130 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5858 9.2305 -0.4617 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2335 9.9577 -0.1833 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5628 11.5692 -0.1997 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1643 11.6734 -0.5023 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7005 10.2858 -0.6435 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8817 12.8179 -0.6069 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5761 12.7271 0.0212 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1071 14.1974 0.1417 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3841 15.4721 -0.3439 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4375 14.6335 0.7697 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8887 15.5451 -1.0971 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6693 15.7093 0.0782 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1739 15.7823 -0.6749 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0920 15.7103 -2.0141 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9332 15.9271 0.1421 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5455 16.1307 0.6732 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3018 16.6687 -0.0029 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0180 18.2952 -0.3000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8099 17.0973 1.2103 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6743 18.6246 0.4648 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0885 19.2121 0.6598 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3504 5.2335 -0.3434 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0507 4.4196 -0.1255 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0929 2.8806 -0.1781 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4277 2.1535 -0.4467 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7183 2.9608 -0.6625 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6853 4.4946 -0.6195 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8271 2.0824 0.0339 O 0 0 0 0 0 0 0 0 0 0 0 0 4.9521 0.4997 -0.0352 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8977 9.7138 0.2496 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9673 6.9820 0.1618 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6479 7.1144 -0.7267 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7333 10.0506 -0.8468 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3984 12.5054 0.1015 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1723 13.9762 1.2076 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8594 16.4980 -1.8455 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7052 14.5281 -1.7303 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6987 14.7565 0.8266 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8528 16.7264 0.7114 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 15.9690 -0.3905 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2123 18.5361 -1.4720 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8732 18.5693 -0.0107 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7444 17.2234 2.4140 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8683 16.5890 0.9095 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4556 19.3958 0.9788 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9268 18.5214 -0.7162 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0421 20.3745 0.3191 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7669 19.1194 1.8249 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0131 4.9868 0.0841 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4582 0.9536 -0.4868 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7542 2.3896 -0.8703 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6943 5.1222 -0.7942 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3632 0.1744 -1.1282 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7246 0.1178 0.8171 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8638 0.0000 0.1523 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 28 29 2 0 0 0 0 28 32 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 30 31 2 0 0 0 0 30 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (435) 434 > (435) C27H26N2O4 > (435) 442.5134 > (435) FGFR-P434 > (435) Indolin-2-one deriv. 9g > (435) FGFR-1 Tyrosine Kinase > (435) 1350 > (435) BINDDB > (435) <2007 > (435) P > (435) TRAIN $$$$ Indolin-2-one deriv. 9h csChFnd70/04170815452D 59 63 0 0 0 0 0 0 0 0999 V2000 6.9347 9.5699 0.0473 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9801 7.7818 -0.0138 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5459 6.9254 -0.3375 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0667 7.8689 -0.5999 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0320 9.6705 -0.5405 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4521 10.5197 -0.2142 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8366 12.4027 -0.2331 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7079 12.5247 -0.5867 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3340 10.9036 -0.7537 N 0 0 3 0 0 0 0 0 0 0 0 0 11.5458 13.8621 -0.7086 O 0 0 0 0 0 0 0 0 0 0 0 0 7.6837 13.7552 0.0257 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3040 15.4732 0.1668 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4591 16.9626 -0.4000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8584 15.9827 0.9007 N 0 0 3 0 0 0 0 0 0 0 0 0 5.7118 17.0478 -1.2796 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2873 17.2391 0.0937 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5401 17.3243 -0.7859 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4441 17.2406 -2.3506 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0905 17.4932 0.1689 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9844 17.7323 0.7883 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5313 18.3606 -0.0013 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1993 20.2610 -0.3481 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4619 18.8615 1.4154 C 0 0 0 0 0 0 0 0 0 0 0 0 11.3031 20.6460 0.5445 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4500 21.3323 0.7736 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5897 5.0009 -0.4016 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8377 4.0258 0.9344 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8847 2.2275 0.8638 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6721 1.4019 -0.5227 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4175 2.3631 -1.8470 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3737 4.1549 -1.7973 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0645 4.8387 2.2971 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3242 3.7587 3.6133 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7231 10.2342 0.2919 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8047 7.0427 0.1892 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2739 7.1983 -0.8493 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5409 10.6291 -0.9917 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3079 13.4960 0.1199 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7171 15.2148 1.4118 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6773 18.1613 -2.1539 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4975 15.8596 -2.0197 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3219 16.1256 0.9680 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5016 18.4272 0.8339 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.5420 -0.4533 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4260 20.5427 -1.7172 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8618 20.5810 -0.0097 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3856 19.0088 2.8219 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6984 18.2676 1.0638 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2162 21.5468 1.1449 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5978 20.5254 -0.8354 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3957 22.6904 0.3757 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0745 21.2237 2.1347 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3056 1.4703 1.8936 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7064 0.0000 -0.5727 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0305 1.7085 -2.9262 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9511 4.9007 -2.8362 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3219 2.9375 3.0416 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3352 2.9445 4.1797 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7508 4.5700 4.6225 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 31 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 32 1 0 0 0 0 28 29 2 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 30 31 2 0 0 0 0 30 55 1 0 0 0 0 31 56 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (436) 435 > (436) C27H26N2O4 > (436) 442.5134 > (436) FGFR-P435 > (436) Indolin-2-one deriv. 9h > (436) FGFR-1 Tyrosine Kinase > (436) 80 > (436) BINDDB > (436) <2007 > (436) P > (436) TRAIN $$$$ Indolin-2-one deriv. 9i csChFnd70/04170815452D 59 63 0 0 0 0 0 0 0 0999 V2000 5.9338 10.4542 0.0405 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9726 8.9241 -0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3125 8.1913 -0.2891 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6138 8.9985 -0.5137 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5843 10.5402 -0.4623 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2323 11.2670 -0.1835 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5614 12.8783 -0.1996 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1627 12.9827 -0.5024 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6989 11.5955 -0.6434 N 0 0 3 0 0 0 0 0 0 0 0 0 9.8799 14.1271 -0.6061 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5750 14.0357 0.0220 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1058 15.5059 0.1428 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3829 16.7804 -0.3424 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4362 15.9418 0.7708 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8874 16.8534 -1.0942 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6689 17.0179 0.0814 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1734 17.0910 -0.6705 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0905 17.0190 -2.0095 O 0 0 0 0 0 0 0 0 0 0 0 0 0.9332 17.2361 0.1471 O 0 0 0 0 0 0 0 0 0 0 0 0 8.5444 17.4390 0.6737 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3009 17.9767 -0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0171 19.6030 -0.2991 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8088 18.4051 1.2102 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6735 19.9318 0.4643 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0881 20.5197 0.6599 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3498 6.5440 -0.3440 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6861 5.8058 -0.6141 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7170 4.2738 -0.6645 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0883 4.1977 -0.1711 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0500 5.7296 -0.1193 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4194 3.4663 -0.4472 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4536 1.9569 -0.4980 O 0 0 0 0 0 0 0 0 0 0 0 0 6.0783 1.1960 -0.2649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8971 11.0228 0.2498 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9669 8.2916 0.1619 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6467 8.4247 -0.7276 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7315 11.3603 -0.8468 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3975 13.8140 0.1027 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1707 15.2846 1.2083 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8577 17.8062 -1.8428 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7033 15.8366 -1.7274 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6987 16.0653 0.8298 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8528 18.0350 0.7144 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.2780 -0.3849 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2106 19.8435 -1.4710 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8727 19.8772 -0.0090 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7435 18.5317 2.4137 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8670 17.8964 0.9098 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4549 20.7028 0.9777 H 0 0 0 0 0 0 0 0 0 0 0 0 9.9260 19.8281 -0.7165 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0418 21.6818 0.3191 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7674 20.4272 1.8249 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6956 6.4334 -0.7840 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7517 3.7015 -0.8736 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0810 3.5666 -0.0021 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0143 6.2981 0.0954 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6430 1.4752 0.8311 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2816 1.5326 -1.1137 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2616 0.0000 -0.3342 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 1 6 2 0 0 0 0 1 34 1 0 0 0 0 2 3 2 0 0 0 0 2 35 1 0 0 0 0 3 4 1 0 0 0 0 3 26 1 0 0 0 0 4 5 2 0 0 0 0 4 36 1 0 0 0 0 5 9 1 0 0 0 0 5 6 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 7 11 2 0 0 0 0 8 9 1 0 0 0 0 8 10 2 0 0 0 0 9 37 1 0 0 0 0 11 12 1 0 0 0 0 11 38 1 0 0 0 0 12 13 2 0 0 0 0 12 14 1 0 0 0 0 13 21 1 0 0 0 0 13 15 1 0 0 0 0 14 20 1 0 0 0 0 14 39 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 15 41 1 0 0 0 0 16 17 1 0 0 0 0 16 42 1 0 0 0 0 16 43 1 0 0 0 0 17 19 1 0 0 0 0 17 18 2 0 0 0 0 19 44 1 0 0 0 0 20 23 1 0 0 0 0 20 21 2 0 0 0 0 21 22 1 0 0 0 0 22 25 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 25 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 25 52 1 0 0 0 0 26 30 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 27 53 1 0 0 0 0 28 31 2 0 0 0 0 28 54 1 0 0 0 0 29 31 1 0 0 0 0 29 30 2 0 0 0 0 29 55 1 0 0 0 0 30 56 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 33 59 1 0 0 0 0 M END > (437) 436 > (437) C27H26N2O4 > (437) 442.5134 > (437) FGFR-P436 > (437) Indolin-2-one deriv. 9i > (437) FGFR-1 Tyrosine Kinase > (437) 880 > (437) BINDDB > (437) <2007 > (437) P > (437) TRAIN $$$$ 1,6-naphthyridin 30 csChFnd70/04170815452D 56 58 0 0 0 0 0 0 0 0999 V2000 1.1276 15.2428 0.5726 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3364 12.5071 0.3582 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9726 13.1511 0.0429 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7361 16.0195 0.2618 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2057 14.9507 -0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9324 17.8276 0.2134 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9675 17.3443 -0.3623 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5662 18.4882 -0.1022 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9899 13.5498 0.6086 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7551 15.6546 -0.3116 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8440 20.3846 -0.1673 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4255 22.9039 0.7248 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1726 21.1381 0.7910 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7823 21.4202 -1.1928 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0474 23.1844 -1.2488 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3636 23.9257 -0.2899 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0901 10.7270 0.4152 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5567 9.5584 0.1427 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9385 7.6829 0.2713 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4701 6.4625 -0.0135 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5973 18.0130 -0.6772 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8518 4.5869 0.1151 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3225 3.4151 -0.1582 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5884 3.5712 1.2501 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2935 2.7305 0.7006 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7350 1.6184 -0.3496 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9595 1.3664 -2.1528 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.0384 0.7888 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0516 12.2870 -0.1576 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8407 18.6753 0.4159 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4543 23.4891 1.4669 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0023 20.3415 1.5839 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7546 20.8426 -1.9424 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2259 23.9880 -2.0433 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5661 25.3071 -0.3375 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9472 10.2586 0.6356 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1072 9.7853 -1.1352 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5379 9.7984 1.1264 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3880 7.4561 1.5491 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9574 7.4431 -0.7125 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0206 6.6894 -1.2913 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4513 6.7023 0.9703 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5685 17.2397 -0.8576 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7686 19.2553 -0.7174 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3013 4.3601 1.3930 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8707 4.3471 -0.8686 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8072 4.9344 1.5362 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0940 2.9231 2.4004 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0626 1.3844 0.3510 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8213 3.4206 -0.4099 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2115 2.7878 1.7690 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8296 0.7457 -0.1826 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7568 1.3373 0.6261 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7684 2.1129 -2.2607 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8799 1.8067 -3.1259 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6779 0.0000 -2.3566 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 28 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 29 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 30 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 31 1 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 35 1 0 0 0 0 17 18 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 19 20 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 22 1 0 0 0 0 20 41 1 0 0 0 0 20 42 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 26 1 0 0 0 0 23 24 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 M END > (45) 43 > (45) C22H29N5 > (45) 363.5046 > (45) FGFR-P43 > (45) 1,6-naphthyridine 30 > (45) FGFR-1 Tyrosine Kinase > (45) 7300 > (45) BINDDB > (45) <2007 > (45) P > (45) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 1 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9969 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6956 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7758 5.8793 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3208 4.9107 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8585 7.6816 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 7.3975 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4673 8.4429 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3044 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1948 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8373 5.7091 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5563 8.1651 -0.0301 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9830 7.1849 -0.0489 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8608 5.6281 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5454 7.9306 -0.0593 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0963 6.8651 -0.0799 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0966 5.7398 -1.6910 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0214 -0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1265 5.7214 1.5180 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6317 10.3402 0.0090 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8772 12.9956 1.5618 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7236 11.2281 1.5624 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7026 11.2439 -1.5363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8564 13.0114 -1.5197 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9400 13.8850 0.0252 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6442 10.1141 3.4924 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5985 10.1498 -3.4764 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6345 0.6597 -0.0245 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6901 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7039 8.4503 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6538 9.4071 -0.0239 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6429 9.1726 -0.0532 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0750 6.5545 -2.8294 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2506 4.9470 -1.7062 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9646 4.9160 -1.6851 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6850 8.8231 1.0596 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8392 7.2287 -0.1035 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6637 8.8360 -1.2266 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9946 4.8977 1.5239 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2805 4.9287 1.5026 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1263 6.5232 2.6657 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9484 13.6846 2.7637 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9118 13.7127 -2.7152 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0601 15.2670 0.0315 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5347 0.0742 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6914 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 27 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 11 1 0 0 0 0 7 19 1 0 0 0 0 11 12 1 0 0 0 0 11 30 1 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 14 15 1 0 0 0 0 14 31 1 0 0 0 0 15 16 1 0 0 0 0 15 17 1 0 0 0 0 15 18 1 0 0 0 0 16 32 1 0 0 0 0 16 33 1 0 0 0 0 16 34 1 0 0 0 0 17 35 1 0 0 0 0 17 36 1 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 41 1 0 0 0 0 21 25 1 0 0 0 0 22 23 1 0 0 0 0 22 26 1 0 0 0 0 23 24 2 0 0 0 0 23 42 1 0 0 0 0 24 43 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 M END > (443) 442 > (443) C18H18Cl2N6O > (443) 405.2858 > (443) FGFR-P442 > (443) PD089828 > (443) FGFR-1 Tyrosine Kinase > (443) 140 > (443) BINDDB > (443) <2007 > (443) P > (443) TRAIN $$$$ PD089828 analog 10 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9969 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4338 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7762 5.8795 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3207 4.9110 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8588 7.6818 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4674 8.4432 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3045 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1946 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8373 5.7094 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6349 0.6596 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6317 10.3403 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8835 12.9966 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6872 11.2474 -1.5351 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8398 13.0164 -1.5165 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9376 13.8874 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9483 7.3977 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5567 8.1652 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9834 7.1851 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8611 5.6285 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5457 7.9308 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0962 5.7400 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6856 8.0213 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0966 6.8653 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1276 5.7216 1.5154 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7242 11.2280 1.5651 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6641 10.3604 3.0667 F 0 0 0 0 0 0 0 0 0 0 0 0 4.5924 10.3985 -3.0455 F 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6900 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7041 8.4502 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9555 13.6850 2.7669 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8833 13.7199 -2.7113 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0621 15.2689 0.0360 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6542 9.4074 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6432 9.1727 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0742 6.5547 -2.8318 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2502 4.9472 -1.7094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9642 4.9162 -1.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6858 8.8231 1.0565 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8395 7.2288 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6636 8.8362 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9954 4.8979 1.5217 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2814 4.9288 1.4996 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1278 6.5232 2.6631 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 32 1 0 0 0 0 13 14 1 0 0 0 0 13 27 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (444) 443 > (444) C18H18F2N6O > (444) 372.3766 > (444) FGFR-P443 > (444) PD089828 analog 10 > (444) FGFR-1 Tyrosine Kinase > (444) 110 > (444) BINDDB > (444) <2007 > (444) P > (444) TRAIN $$$$ PD089828 analog 11 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9965 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7762 5.8791 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3209 4.9106 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8589 7.6813 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4676 8.4427 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 3.3043 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1944 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8373 5.7090 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6349 0.6597 -0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6319 10.3401 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8579 13.0967 -1.1424 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7179 11.1411 1.1864 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8669 12.9105 1.1909 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9389 13.8869 0.0289 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9482 7.3974 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5563 8.1650 -0.0302 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9830 7.1848 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8609 5.6281 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5453 7.9304 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0965 5.7397 -1.6911 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0214 -0.0884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0962 6.8650 -0.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1265 5.7215 1.5178 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7062 11.3275 -1.1614 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9609 14.0551 -2.2772 F 0 0 0 0 0 0 0 0 0 0 0 0 6.9188 13.6884 2.3308 F 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6896 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7042 8.4499 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5351 0.0741 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 0.0000 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4417 10.3807 2.0932 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0543 15.2694 0.0397 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6538 9.4070 -0.0240 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6428 9.1725 -0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0749 6.5544 -2.8295 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2504 4.9470 -1.7064 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9645 4.9160 -1.6852 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6849 8.8230 1.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8391 7.2286 -0.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6635 8.8361 -1.2266 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9946 4.8976 1.5237 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2805 4.9287 1.5025 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1264 6.5231 2.6656 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8675 10.7120 -2.0788 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 26 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 27 1 0 0 0 0 15 33 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 34 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 35 1 0 0 0 0 21 23 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 25 45 1 0 0 0 0 M END > (445) 444 > (445) C18H18F2N6O > (445) 372.3766 > (445) FGFR-P444 > (445) PD089828 analog 11 > (445) FGFR-1 Tyrosine Kinase > (445) 1100 > (445) BINDDB > (445) <2007 > (445) P > (445) TRAIN $$$$ PD089828 analog 13 csChFnd70/04170815452D 48 50 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9968 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6962 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8794 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3212 4.9109 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8590 7.6817 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4679 8.4431 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3045 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2104 3.1945 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8376 5.7093 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6597 -0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6321 10.3406 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4912 12.9546 -1.3820 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0777 11.2831 1.4278 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2338 13.0492 1.4299 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9387 13.8836 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9485 7.3978 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5567 8.1654 -0.0302 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9835 7.1852 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8613 5.6284 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3484 11.1881 -1.3952 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9581 10.1774 -2.9295 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5459 7.9308 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0968 6.8654 -0.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0972 5.7400 -1.6912 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6859 8.0217 -0.0884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1272 5.7216 1.5179 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6899 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7043 8.4503 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 0.0000 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0455 13.6127 -2.4702 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5267 10.6329 2.5224 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8043 13.7808 2.5274 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0535 15.2661 0.0338 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6542 9.4075 -0.0240 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9079 10.0402 -3.8453 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0236 10.8511 -3.5386 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3838 8.9099 -2.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6434 9.1729 -0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0755 6.5548 -2.8296 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2511 4.9472 -1.7066 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9651 4.9161 -1.6853 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6856 8.8234 1.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8399 7.2289 -0.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6643 8.8364 -1.2267 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9951 4.8979 1.5238 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2811 4.9290 1.5026 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1270 6.5234 2.6657 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 27 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 28 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 29 1 0 0 0 0 10 30 1 0 0 0 0 11 20 1 0 0 0 0 11 13 2 0 0 0 0 12 20 2 0 0 0 0 12 15 1 0 0 0 0 12 31 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 22 1 0 0 0 0 18 19 2 0 0 0 0 20 21 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 22 23 1 0 0 0 0 22 39 1 0 0 0 0 23 24 1 0 0 0 0 23 25 1 0 0 0 0 23 26 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 M END > (447) 446 > (447) C19H22N6O > (447) 350.4224 > (447) FGFR-P446 > (447) PD089828 analog 13 > (447) FGFR-1 Tyrosine Kinase > (447) 1400 > (447) BINDDB > (447) <2007 > (447) P > (447) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 15 csChFnd70/04170815452D 51 53 0 0 0 0 0 0 0 0999 V2000 1.2089 5.0280 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7124 2.4488 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7931 5.9157 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3477 4.9410 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8764 7.7291 0.0111 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9851 7.4434 -0.0195 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4952 8.4951 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2320 3.3248 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2364 3.2144 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8737 5.7443 -0.0282 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6605 10.4044 0.0090 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9067 13.0738 1.5714 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7529 11.2969 1.5713 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7317 11.3129 -1.5449 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8855 13.0897 -1.5290 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9698 13.9692 0.0253 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6509 0.6638 -0.0252 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6414 10.3565 -3.2393 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6843 10.3233 3.2568 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6031 8.2157 -0.0309 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0388 7.2294 -0.0505 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9158 5.6630 -0.0583 O 0 0 0 0 0 0 0 0 0 0 0 0 10.6107 7.9797 -0.0615 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1713 6.9077 -0.0828 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1710 5.7755 -1.7039 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7702 8.0714 -0.0917 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2026 5.7570 1.5249 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7253 0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7146 8.5026 0.0260 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9779 13.7667 2.7811 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9409 13.7950 -2.7323 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0897 15.3598 0.0317 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5444 0.0747 -0.0178 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7143 0.0000 -0.0389 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2963 10.2400 -3.6417 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3646 11.0661 -4.2182 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1979 9.0718 -3.0836 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9909 9.9735 3.6506 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0977 11.1373 4.2457 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9146 9.1548 3.0932 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7012 9.4655 -0.0247 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7088 9.2296 -0.0553 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1488 6.5952 -2.8493 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3322 4.9779 -1.7198 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0321 4.9465 -1.6976 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7703 8.8779 1.0631 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9313 7.2736 -0.1075 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7480 8.8911 -1.2371 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0635 4.9281 1.5312 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3636 4.9595 1.5090 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2027 6.5637 2.6799 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 17 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 10 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 10 2 0 0 0 0 6 7 1 0 0 0 0 6 20 1 0 0 0 0 7 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 30 1 0 0 0 0 13 19 1 0 0 0 0 14 15 1 0 0 0 0 14 18 1 0 0 0 0 15 16 2 0 0 0 0 15 31 1 0 0 0 0 16 32 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 18 35 1 0 0 0 0 18 36 1 0 0 0 0 18 37 1 0 0 0 0 19 38 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 M END > (449) 448 > (449) C20H24N6O > (449) 364.4492 > (449) FGFR-P448 > (449) PD089828 analog 15 > (449) FGFR-1 Tyrosine Kinase > (449) 400 > (449) BINDDB > (449) <2007 > (449) P > (449) TRAIN $$$$ PD089828 analog 16 csChFnd70/04170815452D 51 53 0 0 0 0 0 0 0 0999 V2000 1.2126 5.0429 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7210 2.4561 -0.0163 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8018 5.9336 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3610 4.9562 -0.0185 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8853 7.7524 0.0111 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5091 8.5209 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2358 3.3350 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2493 3.2239 -0.0268 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8914 5.7619 -0.0283 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6593 0.6658 -0.0253 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6749 10.4359 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5418 13.0740 -1.3947 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1154 11.3871 1.4410 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2729 13.1694 1.4431 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9843 14.0115 0.0290 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0033 7.4659 -0.0196 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6263 8.2406 -0.0305 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0662 7.2514 -0.0495 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9430 5.6803 -0.0573 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3977 11.2912 -1.4081 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6432 8.0039 -0.0600 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2083 6.9286 -0.0808 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2087 5.7929 -1.7067 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8120 8.0956 -0.0892 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2389 5.7744 1.5318 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0130 10.2713 -2.9565 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3223 14.0006 -2.9272 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7424 0.0331 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7199 8.5281 0.0261 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5494 0.0748 -0.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7260 0.0000 -0.0390 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5591 10.7309 2.5456 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8394 13.9078 2.5506 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1000 15.4067 0.0341 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7247 9.4941 -0.0242 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7416 9.2574 -0.0538 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1868 6.6152 -2.8556 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3732 4.9928 -1.7223 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0662 4.9615 -1.7008 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8117 8.9047 1.0692 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9766 7.2955 -0.1046 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7902 8.9178 -1.2380 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0965 4.9431 1.5378 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4035 4.9744 1.5164 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2388 6.5835 2.6902 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9532 10.1328 -3.8807 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0883 10.9512 -3.5713 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4426 8.9920 -2.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3029 14.3258 -3.8501 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9561 15.1849 -2.4888 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2724 13.1613 -3.5513 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 20 1 0 0 0 0 11 13 2 0 0 0 0 12 20 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 21 1 0 0 0 0 18 19 2 0 0 0 0 20 26 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 25 1 0 0 0 0 23 37 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 25 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 M END > (450) 449 > (450) C20H24N6O > (450) 364.4492 > (450) FGFR-P449 > (450) PD089828 analog 16 > (450) FGFR-1 Tyrosine Kinase > (450) 340 > (450) BINDDB > (450) <2007 > (450) P > (450) TRAIN $$$$ 1,6-naphthyridin 31 csChFnd70/04170815452D 72 74 0 0 0 0 0 0 0 0999 V2000 1.1316 15.2943 0.5750 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3445 12.5494 0.3597 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9864 13.1954 0.0434 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7459 16.0737 0.2631 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2206 15.0011 -0.0117 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9434 17.8875 0.2145 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9883 17.4018 -0.3632 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5839 18.5497 -0.1024 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9936 13.5958 0.6111 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7751 15.7074 -0.3123 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8637 20.4524 -0.1678 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0609 23.2632 -1.2470 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7943 21.4930 -1.1911 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1926 21.2087 0.7994 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4470 22.9804 0.7332 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3860 24.0056 -0.2898 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0972 10.7632 0.4164 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5687 9.5904 0.1428 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9481 7.7085 0.2710 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4847 6.4838 -0.0147 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8641 4.6018 0.1134 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3395 3.4260 -0.1608 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6095 3.5820 1.2526 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3206 2.7382 0.7013 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7497 1.6230 -0.3535 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9721 1.3710 -2.1632 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6297 18.0747 -0.6802 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9835 16.9960 -0.9319 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7676 15.4338 -0.8813 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5768 17.6492 -1.2396 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0484 16.4765 -1.5132 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6908 15.3219 -3.0886 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6933 17.5423 -1.8333 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2983 15.3411 0.0967 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.0925 0.7920 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0690 12.3280 -0.1574 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8484 18.7385 0.4177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2331 24.0705 -2.0393 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7592 20.9146 -1.9390 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0213 20.4096 1.5992 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4763 23.5678 1.4819 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5896 25.3917 -0.3372 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9503 10.2933 0.6370 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1214 9.8185 -1.1394 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5530 9.8307 1.1301 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3953 7.4806 1.5532 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9637 7.4683 -0.7163 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0374 6.7117 -1.2969 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4690 6.7240 0.9727 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3114 4.3739 1.3956 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8798 4.3616 -0.8739 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8294 4.9495 1.5402 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1132 2.9312 2.4066 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2416 2.7952 1.7737 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0886 1.3876 0.3500 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8505 3.4308 -0.4127 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8480 0.7472 -0.1861 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7681 1.3409 0.6251 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6893 0.0000 -2.3683 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7770 2.1203 -2.2715 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8958 1.8131 -3.1394 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8019 19.3212 -0.7206 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7491 18.8956 -1.2801 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5129 16.1308 -4.2355 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7858 14.4495 -3.2923 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5191 14.5626 -2.8607 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9480 18.3649 -0.7109 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7881 16.6698 -2.0368 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5153 18.3511 -2.9803 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1264 14.5821 0.3247 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3932 14.4687 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5531 16.1637 1.2190 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 37 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 27 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 39 1 0 0 0 0 14 15 1 0 0 0 0 14 40 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 42 1 0 0 0 0 17 18 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 19 20 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 20 21 1 0 0 0 0 20 48 1 0 0 0 0 20 49 1 0 0 0 0 21 22 1 0 0 0 0 21 50 1 0 0 0 0 21 51 1 0 0 0 0 22 25 1 0 0 0 0 22 23 1 0 0 0 0 23 24 1 0 0 0 0 23 52 1 0 0 0 0 23 53 1 0 0 0 0 24 54 1 0 0 0 0 24 55 1 0 0 0 0 24 56 1 0 0 0 0 25 26 1 0 0 0 0 25 57 1 0 0 0 0 25 58 1 0 0 0 0 26 59 1 0 0 0 0 26 60 1 0 0 0 0 26 61 1 0 0 0 0 27 28 1 0 0 0 0 27 62 1 0 0 0 0 28 29 2 0 0 0 0 28 30 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 31 32 1 0 0 0 0 31 33 1 0 0 0 0 31 34 1 0 0 0 0 32 64 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 33 67 1 0 0 0 0 33 68 1 0 0 0 0 33 69 1 0 0 0 0 34 70 1 0 0 0 0 34 71 1 0 0 0 0 34 72 1 0 0 0 0 M END > (46) 44 > (46) C27H38N6O > (46) 462.6368 > (46) FGFR-P44 > (46) 1,6-naphthyridine 31 > (46) FGFR-1 Tyrosine Kinase > (46) 300 > (46) BINDDB > (46) <2007 > (46) P > (46) TRAIN $$$$ PD089828 analog 18 csChFnd70/04170815452D 54 56 0 0 0 0 0 0 0 0999 V2000 1.2016 4.9974 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6965 2.4340 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7766 5.8800 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3217 4.9114 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8593 7.6825 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4684 8.4440 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2246 3.3048 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2109 3.1949 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8383 5.7099 -0.0274 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6353 0.6598 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6327 10.3417 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8778 12.9941 1.5650 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6881 11.2471 -1.5338 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8410 13.0134 -1.5166 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9491 7.3986 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5575 8.1663 -0.0294 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9846 7.1858 -0.0470 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8623 5.6290 -0.0541 O 0 0 0 0 0 0 0 0 0 0 0 0 4.7249 11.2278 1.5637 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5471 7.9317 -0.0567 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0982 6.8661 -0.0758 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0996 5.7399 -1.6866 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6875 8.0226 -0.0835 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1276 5.7229 1.5229 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6572 10.2590 3.2384 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9394 13.8851 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1066 15.8139 0.0388 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5816 10.2992 -3.2183 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6905 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7045 8.4512 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5354 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6924 0.0000 -0.0382 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9493 13.6819 2.7677 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8846 13.7161 -2.7120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6550 9.4085 -0.0238 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6446 9.1739 -0.0510 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0788 6.5542 -2.8254 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2537 4.9470 -1.7008 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9675 4.9161 -1.6811 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6865 8.8248 1.0640 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8415 7.2297 -0.0976 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6666 8.8369 -1.2223 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9953 4.8991 1.5284 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2816 4.9302 1.5086 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1265 6.5253 2.6705 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9559 9.9111 3.6292 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0744 11.0673 4.2220 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8920 9.0976 3.0752 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4619 16.1650 0.0280 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4784 16.3426 -1.0954 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5001 16.3289 1.1911 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2407 10.1840 -3.6050 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2908 11.0059 -4.1972 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1362 9.0218 -3.0709 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 29 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 30 1 0 0 0 0 6 15 1 0 0 0 0 6 11 1 0 0 0 0 9 15 2 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 19 1 0 0 0 0 11 13 2 0 0 0 0 12 19 2 0 0 0 0 12 26 1 0 0 0 0 12 33 1 0 0 0 0 13 14 1 0 0 0 0 13 28 1 0 0 0 0 14 26 2 0 0 0 0 14 34 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 16 35 1 0 0 0 0 17 20 1 0 0 0 0 17 18 2 0 0 0 0 19 25 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 24 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 22 39 1 0 0 0 0 23 40 1 0 0 0 0 23 41 1 0 0 0 0 23 42 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 27 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 M END > (452) 451 > (452) C21H26N6O > (452) 378.476 > (452) FGFR-P451 > (452) PD089828 analog 18 > (452) FGFR-1 Tyrosine Kinase > (452) 270 > (452) BINDDB > (452) <2007 > (452) P > (452) TRAIN $$$$ PD089828 analog 21 csChFnd70/04170815452D 72 74 0 0 0 0 0 0 0 0999 V2000 1.1614 5.2201 -1.6708 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4559 2.5245 -2.1710 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8420 5.9757 -1.5847 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3285 4.8761 -1.8141 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0854 7.7772 -1.2790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7898 8.4085 -1.2146 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0353 3.5199 -1.9614 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0643 3.1629 -2.1032 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9424 5.5519 -1.7394 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2371 0.7493 -2.4714 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1246 10.2988 -0.8952 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6354 12.6864 1.1027 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2338 11.4620 -2.3034 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5450 13.2213 -2.0024 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2042 7.2371 -1.4545 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9086 7.8745 -1.3895 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2742 6.7732 -1.6167 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0122 5.2212 -1.8787 O 0 0 0 0 0 0 0 0 0 0 0 0 5.3235 10.9193 0.8135 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9299 7.3924 -1.5536 N 0 0 3 0 0 0 0 0 0 0 0 0 12.4142 6.1953 -1.8006 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2865 5.3354 -3.6108 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1334 7.2244 -1.6681 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3727 4.7758 -0.3807 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1990 9.6708 2.3425 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7490 13.8348 -0.3075 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0127 10.7986 -4.1536 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1488 15.1337 2.9691 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8302 13.2965 2.7675 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3306 15.5713 4.9205 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5043 15.4230 4.8474 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0388 14.1760 5.1982 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8974 14.7009 5.6311 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9478 14.8310 7.5541 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6306 13.5392 8.3471 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.0139 -1.4969 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9780 8.6441 -1.1004 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0663 0.2524 -2.5259 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2544 0.0000 -2.6278 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6296 14.1210 -3.0947 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1175 9.1129 -1.1806 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1390 8.6307 -1.3446 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3161 6.3466 -4.6223 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3908 4.4447 -3.7945 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0617 4.6022 -3.7051 H 0 0 0 0 0 0 0 0 0 0 0 0 14.2243 7.8369 -0.3785 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2377 6.3336 -1.8519 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1630 8.2357 -2.6797 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1478 4.0427 -0.4751 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4769 3.8851 -0.5645 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4635 5.3884 0.9088 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4973 9.1470 2.6374 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6943 10.3664 3.4862 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3154 8.5959 2.0098 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9919 15.2125 -0.0791 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6312 10.8597 -4.5202 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7794 11.6121 -5.0465 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4676 9.4446 -4.2323 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3559 15.4860 2.2869 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0553 15.8711 2.4150 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4571 16.9872 5.0819 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1712 15.1131 5.6220 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7855 16.7002 5.4274 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3222 15.5698 3.4361 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2345 14.7203 4.6317 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2098 14.0155 6.6094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7653 12.9041 4.6031 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2637 14.5160 8.0191 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6078 16.1626 7.9510 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7581 13.5425 9.7720 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3027 13.9305 7.9863 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8926 12.2244 7.8478 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 36 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 37 1 0 0 0 0 6 15 1 0 0 0 0 6 11 1 0 0 0 0 9 15 2 0 0 0 0 10 38 1 0 0 0 0 10 39 1 0 0 0 0 11 19 1 0 0 0 0 11 13 2 0 0 0 0 12 19 2 0 0 0 0 12 26 1 0 0 0 0 12 29 1 0 0 0 0 13 14 1 0 0 0 0 13 27 1 0 0 0 0 14 26 2 0 0 0 0 14 40 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 16 41 1 0 0 0 0 17 20 1 0 0 0 0 17 18 2 0 0 0 0 19 25 1 0 0 0 0 20 21 1 0 0 0 0 20 42 1 0 0 0 0 21 22 1 0 0 0 0 21 23 1 0 0 0 0 21 24 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 22 45 1 0 0 0 0 23 46 1 0 0 0 0 23 47 1 0 0 0 0 23 48 1 0 0 0 0 24 49 1 0 0 0 0 24 50 1 0 0 0 0 24 51 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 55 1 0 0 0 0 27 56 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 29 1 0 0 0 0 28 30 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 30 33 1 0 0 0 0 30 61 1 0 0 0 0 30 62 1 0 0 0 0 31 33 1 0 0 0 0 31 32 1 0 0 0 0 31 63 1 0 0 0 0 31 64 1 0 0 0 0 32 65 1 0 0 0 0 32 66 1 0 0 0 0 32 67 1 0 0 0 0 33 34 1 0 0 0 0 34 35 1 0 0 0 0 34 68 1 0 0 0 0 34 69 1 0 0 0 0 35 70 1 0 0 0 0 35 71 1 0 0 0 0 35 72 1 0 0 0 0 M END > (454) 453 > (454) C26H37N7O2 > (454) 479.624 > (454) FGFR-P453 > (454) PD089828 analog 21 > (454) FGFR-1 Tyrosine Kinase > (454) 890 > (454) BINDDB > (454) <2007 > (454) P > (454) TRAIN $$$$ 1,6-naphthyridin 32 csChFnd70/04170815452D 56 59 0 0 0 0 0 0 0 0999 V2000 1.2247 16.2964 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7174 13.6832 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3193 14.4891 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7852 17.2322 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3829 16.3103 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8107 19.0584 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9439 18.8768 -0.0204 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4086 19.8807 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2478 14.5911 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8908 17.1675 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5084 21.8028 0.0077 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6642 24.4947 1.5764 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5706 22.7038 1.5777 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5483 22.7179 -1.5548 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6420 24.5088 -1.5386 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6971 25.3947 0.0226 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6387 11.8801 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2429 10.8581 -0.0460 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7950 8.9227 -0.0521 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4704 7.8554 -0.0737 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5372 19.7068 -0.0322 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4809 21.6083 -3.5155 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5296 21.5764 3.5289 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6973 5.6021 1.2169 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2133 3.6784 1.0987 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1141 3.0103 0.0911 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5982 4.9340 0.2092 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0404 5.9973 -0.0796 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7711 2.6152 1.3876 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3411 0.7570 1.3816 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9791 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 13.7328 -0.0425 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6188 19.7969 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7120 25.1936 2.7909 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6729 25.2188 -2.7473 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7698 26.7950 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5217 11.2984 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9882 11.1735 -1.2070 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0101 11.1611 1.1040 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0497 8.6072 1.1090 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0277 8.6197 -1.2020 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2157 8.1708 -1.2348 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2376 8.1584 1.0762 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5994 19.0306 -0.0464 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5917 20.9651 -0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5512 6.3936 0.9657 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1930 5.8856 2.5116 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2444 3.3739 2.0844 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6846 3.4025 -0.1848 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6184 2.7268 -1.2037 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2602 2.2189 0.3421 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1269 5.2099 1.4926 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5669 5.2385 -0.7764 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7782 0.4070 0.1313 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5171 0.0000 1.5982 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4090 0.4852 2.4112 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 33 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 21 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 34 1 0 0 0 0 13 23 1 0 0 0 0 14 15 1 0 0 0 0 14 22 1 0 0 0 0 15 16 2 0 0 0 0 15 35 1 0 0 0 0 16 36 1 0 0 0 0 17 18 1 0 0 0 0 17 37 1 0 0 0 0 18 19 1 0 0 0 0 18 38 1 0 0 0 0 18 39 1 0 0 0 0 19 20 1 0 0 0 0 19 40 1 0 0 0 0 19 41 1 0 0 0 0 20 28 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 21 44 1 0 0 0 0 21 45 1 0 0 0 0 24 28 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 29 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 29 30 1 0 0 0 0 30 54 1 0 0 0 0 30 55 1 0 0 0 0 30 56 1 0 0 0 0 M END > (47) 45 > (47) C22H26Cl2N6 > (47) 445.3936 > (47) FGFR-P45 > (47) 1,6-naphthyridine 32 > (47) FGFR-1 Tyrosine Kinase > (47) 120 > (47) BINDDB > (47) <2007 > (47) P > (47) TRAIN $$$$ PD089828 analog 6 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9969 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8794 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3210 4.9108 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8590 7.6816 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4677 8.4431 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 3.3044 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2104 3.1946 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8375 5.7092 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6596 -0.0250 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6320 10.3404 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4924 12.9579 -1.3811 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0776 11.2828 1.4278 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2341 13.0490 1.4312 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9391 13.8854 0.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9484 7.3977 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5567 8.1653 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9834 7.1851 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8612 5.6283 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5458 7.9307 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0964 5.7399 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6857 8.0215 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0966 6.8652 -0.0824 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1276 5.7215 1.5155 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3487 11.1884 -1.3960 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0504 10.0250 -3.1642 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3837 14.0174 -3.1291 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6898 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7043 8.4502 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5351 0.0741 -0.0177 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6918 0.0000 -0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5264 10.6322 2.5219 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8041 13.7794 2.5293 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0539 15.2679 0.0387 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6542 9.4073 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6433 9.1728 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0743 6.5546 -2.8319 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2503 4.9472 -1.7094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9643 4.9161 -1.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6859 8.8232 1.0564 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8396 7.2288 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6637 8.8363 -1.2296 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9956 4.8977 1.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2816 4.9288 1.4997 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1278 6.5231 2.6632 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 32 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (465) 464 > (465) C18H18Cl2N6O > (465) 405.2858 > (465) FGFR-P464 > (465) PD089828 analog 6 > (465) FGFR-1 Tyrosine Kinase > (465) 160 > (465) BINDDB > (465) <2007 > (465) P > (465) TRAIN $$$$ PD089828 analog 7 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9970 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6960 2.4337 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7763 5.8796 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3211 4.9109 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8590 7.6818 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4678 8.4433 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2245 3.3045 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2105 3.1947 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8377 5.7094 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6350 0.6596 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6320 10.3406 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8850 12.9955 1.5648 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6875 11.2466 -1.5343 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8408 13.0144 -1.5174 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9392 13.8865 0.0268 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9485 7.3978 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5569 8.1655 -0.0307 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9837 7.1851 -0.0502 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8614 5.6284 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5459 7.9308 -0.0613 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0966 5.7399 -1.6936 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6860 8.0216 -0.0913 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0968 6.8653 -0.0825 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1279 5.7216 1.5155 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7244 11.2272 1.5644 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6466 10.1119 3.4937 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.0002 14.1022 3.4971 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5649 10.1546 -3.4747 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6901 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7041 8.4504 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5352 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6919 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8842 13.7167 -2.7129 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0647 15.2681 0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6545 9.4076 -0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6435 9.1729 -0.0551 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0745 6.5548 -2.8319 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2506 4.9473 -1.7094 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9644 4.9162 -1.6873 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6863 8.8234 1.0565 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8399 7.2288 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6639 8.8365 -1.2297 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9959 4.8978 1.5218 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2818 4.9289 1.4997 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1280 6.5233 2.6633 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 29 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 30 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 31 1 0 0 0 0 10 32 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 27 1 0 0 0 0 13 14 1 0 0 0 0 13 28 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (466) 465 > (466) C18H17Cl3N6O > (466) 439.7309 > (466) FGFR-P465 > (466) PD089828 analog 7 > (466) FGFR-1 Tyrosine Kinase > (466) 110 > (466) BINDDB > (466) <2007 > (466) P > (466) TRAIN $$$$ 6-arylpyrido[2,3-d]pyrimidine deriv. 19 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2016 4.9969 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6959 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2246 3.3043 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2104 3.1947 -0.0265 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7760 5.8792 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3210 4.9106 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8587 7.6816 0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 7.3974 -0.0217 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4675 8.4430 -0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8374 5.7090 -0.0292 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6317 10.3401 0.0054 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8771 12.9960 1.5563 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8550 13.0100 -1.5250 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9386 13.8847 0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7242 11.2288 1.5580 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7019 11.2428 -1.5403 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6346 0.6597 -0.0245 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6396 10.0165 3.6611 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.5885 10.0493 -3.6528 Br 0 0 0 0 0 0 0 0 0 0 0 0 7.5564 8.1650 -0.0334 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9832 7.1848 -0.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8611 5.6282 -0.0590 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5455 7.9305 -0.0638 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0963 6.8651 -0.0843 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0960 5.7388 -1.6947 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6853 8.0215 -0.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1274 5.7225 1.5143 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6900 0.0214 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7040 8.4502 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9493 13.6857 2.7579 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9093 13.7104 -2.7211 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0583 15.2666 0.0245 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5349 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6915 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6540 9.4071 -0.0281 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6430 9.1727 -0.0584 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0739 6.5527 -2.8335 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2501 4.9460 -1.7098 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9641 4.9150 -1.6877 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6856 8.8239 1.0534 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8393 7.2287 -0.1092 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6633 8.8355 -1.2328 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9954 4.8988 1.5211 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2814 4.9299 1.4991 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1275 6.5250 2.6616 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 1 0 0 0 0 1 5 2 0 0 0 0 1 28 1 0 0 0 0 2 3 2 0 0 0 0 2 4 1 0 0 0 0 2 17 1 0 0 0 0 4 6 2 0 0 0 0 5 7 1 0 0 0 0 5 6 1 0 0 0 0 6 10 1 0 0 0 0 7 9 2 0 0 0 0 7 29 1 0 0 0 0 8 10 2 0 0 0 0 8 9 1 0 0 0 0 8 20 1 0 0 0 0 9 11 1 0 0 0 0 11 15 2 0 0 0 0 11 16 1 0 0 0 0 12 15 1 0 0 0 0 12 14 2 0 0 0 0 12 30 1 0 0 0 0 13 16 2 0 0 0 0 13 14 1 0 0 0 0 13 31 1 0 0 0 0 14 32 1 0 0 0 0 15 18 1 0 0 0 0 16 19 1 0 0 0 0 17 33 1 0 0 0 0 17 34 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 23 1 0 0 0 0 21 22 2 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 24 27 1 0 0 0 0 25 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 26 40 1 0 0 0 0 26 41 1 0 0 0 0 26 42 1 0 0 0 0 27 43 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 M END > (467) 466 > (467) C18H18Br2N6O > (467) 494.1878 > (467) FGFR-P466 > (467) PD089828 analog 8 > (467) FGFR-1 Tyrosine Kinase > (467) 290 > (467) BINDDB > (467) <2007 > (467) P > (467) TRAIN $$$$ PD089828 analog 9 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2015 4.9966 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6959 2.4336 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7762 5.8791 0.0015 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3208 4.9105 -0.0184 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8589 7.6812 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4675 8.4427 0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2244 3.3043 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2102 3.1945 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8372 5.7089 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6349 0.6596 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6318 10.3399 0.0103 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8845 12.9929 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6873 11.2459 -1.5341 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8404 13.0137 -1.5161 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9389 13.8845 0.0289 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9481 7.3973 -0.0194 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5563 8.1649 -0.0302 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9830 7.1846 -0.0491 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8608 5.6280 -0.0568 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5453 7.9302 -0.0595 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0965 5.7396 -1.6911 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6852 8.0210 -0.0884 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0962 6.8648 -0.0800 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1266 5.7211 1.5178 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7241 11.2267 1.5643 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6391 10.0116 3.6656 Br 0 0 0 0 0 0 0 0 0 0 0 0 4.5647 10.1547 -3.4748 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6896 0.0328 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7042 8.4498 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5351 0.0741 -0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6917 0.0000 -0.0381 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9565 13.6808 2.7673 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8840 13.7168 -2.7110 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0637 15.2661 0.0362 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6539 9.4069 -0.0240 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6429 9.1722 -0.0533 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0749 6.5542 -2.8295 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2504 4.9467 -1.7065 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9644 4.9157 -1.6852 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6851 8.8226 1.0594 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8391 7.2283 -0.1036 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6636 8.8357 -1.2266 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9945 4.8974 1.5237 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2805 4.9284 1.5025 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1263 6.5228 2.6656 H 0 0 0 0 0 0 0 0 0 0 0 0 1 7 2 0 0 0 0 1 3 1 0 0 0 0 1 28 1 0 0 0 0 2 7 1 0 0 0 0 2 8 2 0 0 0 0 2 10 1 0 0 0 0 3 5 1 0 0 0 0 3 4 2 0 0 0 0 4 8 1 0 0 0 0 4 9 1 0 0 0 0 5 6 2 0 0 0 0 5 29 1 0 0 0 0 6 16 1 0 0 0 0 6 11 1 0 0 0 0 9 16 2 0 0 0 0 10 30 1 0 0 0 0 10 31 1 0 0 0 0 11 25 1 0 0 0 0 11 13 2 0 0 0 0 12 25 2 0 0 0 0 12 15 1 0 0 0 0 12 32 1 0 0 0 0 13 14 1 0 0 0 0 13 27 1 0 0 0 0 14 15 2 0 0 0 0 14 33 1 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 17 35 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 21 37 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 24 43 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 26 1 0 0 0 0 M END > (468) 467 > (468) C18H18BrClN6O > (468) 449.7368 > (468) FGFR-P467 > (468) PD089828 analog 9 > (468) FGFR-1 Tyrosine Kinase > (468) 180 > (468) BINDDB > (468) <2007 > (468) P > (468) TRAIN $$$$ csChFnd70/04170815452D 62 65 0 0 0 0 0 0 0 0999 V2000 11.7059 11.5154 -0.3611 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0438 10.1479 1.8834 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4205 10.0277 0.4229 N 0 0 0 0 0 0 0 0 0 0 0 0 13.2540 12.3953 -0.0165 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4390 11.6511 1.1538 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6327 13.9933 -0.8171 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3609 13.9949 0.7828 C 0 0 0 0 0 0 0 0 0 0 0 0 17.7226 14.7057 1.1278 O 0 0 0 0 0 0 0 0 0 0 0 0 15.9669 12.4707 1.5259 N 0 0 3 0 0 0 0 0 0 0 0 0 15.1610 14.8012 -0.4389 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5961 16.4770 -1.2570 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4855 16.5153 -2.8256 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8866 18.0816 -3.5815 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4086 19.6105 -2.7874 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5273 19.5815 -1.2322 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1116 18.0238 -0.4662 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9968 17.9902 1.4806 Cl 0 0 0 0 0 0 0 0 0 0 0 0 17.0871 14.5981 -3.8239 Cl 0 0 0 0 0 0 0 0 0 0 0 0 12.5664 9.3657 1.5177 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2027 7.8042 2.3030 N 0 0 3 0 0 0 0 0 0 0 0 0 10.5947 7.0146 2.0455 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1818 11.6803 2.7442 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4707 5.2248 1.9988 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1224 8.0208 1.8437 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5372 7.2411 1.5896 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8844 4.4470 1.7447 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4153 5.4532 1.5360 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8537 4.6865 1.2863 O 0 0 0 0 0 0 0 0 0 0 0 0 4.3955 5.8010 1.0808 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7660 4.7126 0.8159 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4132 3.7085 2.3881 N 0 0 0 0 0 0 0 0 0 0 0 0 1.9635 4.8494 3.8376 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1154 3.8484 5.5361 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0475 2.4250 2.0836 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7885 0.9049 1.0585 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7703 12.0415 -1.2534 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7304 14.5678 -1.7138 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5752 18.1130 -4.7953 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7254 20.8320 -3.3841 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1586 20.7798 -0.6184 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0611 7.2546 3.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 18.0715 10.8426 2.0431 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9092 12.6903 3.4040 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4689 10.9197 3.6917 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6144 4.4412 2.1609 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2168 9.4128 1.8860 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3927 8.0236 1.4275 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7885 3.0551 1.7027 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2465 6.5966 2.2338 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5933 6.6310 -0.0402 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6740 5.5603 0.5452 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9591 3.8345 -0.2687 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8439 5.9490 3.8602 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6413 5.3097 3.6803 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7530 4.6863 6.6089 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2569 2.7319 5.5015 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4444 3.4138 5.7079 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5541 1.9622 3.3193 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.0185 1.3522 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3704 1.3810 -0.1329 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7683 0.2507 1.8310 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7547 0.0000 0.7474 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 36 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 37 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 38 1 0 0 0 0 14 15 1 0 0 0 0 14 39 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 41 1 0 0 0 0 21 23 1 0 0 0 0 21 24 2 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 26 2 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 27 2 0 0 0 0 25 47 1 0 0 0 0 26 27 1 0 0 0 0 26 48 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 31 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 34 1 0 0 0 0 31 32 1 0 0 0 0 32 33 1 0 0 0 0 32 53 1 0 0 0 0 32 54 1 0 0 0 0 33 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 34 35 1 0 0 0 0 34 58 1 0 0 0 0 34 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 35 62 1 0 0 0 0 M END > (470) 469 > (470) C26H27Cl2N5O2 > (470) 512.4376 > (470) FGFR-P469 > (470) PD166285 > (470) FGFR-1 Tyrosine Kinase > (470) 43 > (470) BINDDB > (470) <2007 > (470) P > (470) TRAIN $$$$ 1,6-naphthyridin 33 csChFnd70/04170815452D 66 69 0 0 0 0 0 0 0 0999 V2000 1.2228 16.2730 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 13.6638 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3129 14.4681 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 17.2074 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3767 16.2867 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0303 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9356 18.8482 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4042 19.8507 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2459 14.5705 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8822 17.1425 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5052 21.7701 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6624 24.4577 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5678 22.6696 1.5751 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5455 22.6837 -1.5525 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6403 24.4719 -1.5363 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6956 25.3564 0.0225 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6344 11.8634 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2360 10.8427 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7885 8.9103 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4612 7.8442 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4776 21.5758 -3.5103 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5262 21.5439 3.5237 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6902 5.5942 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2066 3.6735 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1031 3.0063 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5868 4.9269 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0315 5.9889 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7619 2.6115 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3322 0.7562 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5324 19.6792 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0058 18.7404 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9369 17.1658 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5557 19.5472 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1574 18.5267 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7198 19.7485 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9548 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4916 13.7127 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6178 19.7684 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7109 25.1557 2.7866 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6715 25.1808 -2.7433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7696 26.7546 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5190 11.2828 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9804 11.1578 -1.2054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0020 11.1447 1.1020 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0441 8.5951 1.1057 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0226 8.6082 -1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2057 8.1595 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2271 8.1464 1.0736 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5460 6.3847 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1850 5.8767 2.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2389 3.3693 2.0778 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6789 3.3984 -0.1879 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6084 2.7236 -1.2049 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2473 2.2157 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1145 5.2020 1.4885 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5543 5.2312 -0.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7704 0.4072 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5063 0.0000 1.5917 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4011 0.4846 2.4034 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5872 20.9356 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6106 20.8035 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2078 17.7059 1.0668 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1854 17.7176 -1.2405 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9115 18.9892 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6692 20.5692 -1.2407 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6917 20.5576 1.0667 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 36 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 37 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 38 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 30 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 39 1 0 0 0 0 13 22 1 0 0 0 0 14 15 1 0 0 0 0 14 21 1 0 0 0 0 15 16 2 0 0 0 0 15 40 1 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 17 42 1 0 0 0 0 18 19 1 0 0 0 0 18 43 1 0 0 0 0 18 44 1 0 0 0 0 19 20 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 27 1 0 0 0 0 20 47 1 0 0 0 0 20 48 1 0 0 0 0 23 27 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 23 50 1 0 0 0 0 24 28 1 0 0 0 0 24 51 1 0 0 0 0 24 52 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 25 53 1 0 0 0 0 25 54 1 0 0 0 0 26 27 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 28 29 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 29 59 1 0 0 0 0 30 31 1 0 0 0 0 30 60 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 34 35 1 0 0 0 0 34 62 1 0 0 0 0 34 63 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 M END > (48) 46 > (48) C25H31Cl2N7O > (48) 516.4722 > (48) FGFR-P46 > (48) 1,6-naphthyridine 33 > (48) FGFR-1 Tyrosine Kinase > (48) 32 > (48) BINDDB > (48) <2007 > (48) P > (48) TRAIN $$$$ csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 5.0411 7.8401 -0.6082 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6960 6.3302 -0.2145 N 0 0 0 0 0 0 0 0 0 0 0 0 5.0731 6.3602 -0.4132 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4150 8.6365 -0.6098 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7716 7.8196 -0.4027 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4534 10.2223 -0.8138 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2086 10.0662 -0.5888 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4314 10.7024 -0.5802 O 0 0 0 0 0 0 0 0 0 0 0 0 9.1384 8.5559 -0.3975 N 0 0 3 0 0 0 0 0 0 0 0 0 7.8222 10.9476 -0.8069 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9005 12.6088 -1.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0313 13.2181 -2.4691 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1033 14.7677 -2.6584 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0459 15.7152 -1.4139 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9169 15.1185 0.0274 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8373 13.5711 0.2318 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6667 12.8247 2.0408 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.1041 12.0310 -4.0326 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.3725 5.6283 -0.2215 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3411 4.0780 -0.0222 N 0 0 3 0 0 0 0 0 0 0 0 0 4.9560 3.3247 0.1065 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5356 7.6904 -0.1810 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4245 1.1291 -0.3375 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7941 1.8701 -0.4669 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7407 4.0267 0.8133 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2148 1.8338 0.3618 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3737 3.2793 0.9389 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0525 4.0424 1.7006 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0706 3.7008 3.2808 O 0 0 0 0 0 0 0 0 0 0 0 0 3.9804 8.4258 -0.7682 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4184 10.8526 -0.9730 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2048 15.2409 -3.7807 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1026 16.9261 -1.5680 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8731 15.8643 0.9945 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2803 3.5120 0.0286 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9674 7.3259 -1.2774 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3764 8.4000 0.3766 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3028 6.7019 0.5186 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2966 0.0000 -0.7871 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7383 1.3193 -1.0135 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8642 5.1556 1.2646 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1448 1.2519 0.4615 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1359 5.2627 1.5428 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6345 1.2037 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2502 4.1559 3.8440 H 0 0 0 0 0 0 0 0 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 1 30 1 0 0 0 0 2 19 2 0 0 0 0 2 5 1 0 0 0 0 3 19 1 0 0 0 0 4 6 1 0 0 0 0 4 5 2 0 0 0 0 5 9 1 0 0 0 0 6 10 2 0 0 0 0 6 31 1 0 0 0 0 7 9 1 0 0 0 0 7 10 1 0 0 0 0 7 8 2 0 0 0 0 9 22 1 0 0 0 0 10 11 1 0 0 0 0 11 16 1 0 0 0 0 11 12 2 0 0 0 0 12 13 1 0 0 0 0 12 18 1 0 0 0 0 13 14 2 0 0 0 0 13 32 1 0 0 0 0 14 15 1 0 0 0 0 14 33 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 17 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 20 35 1 0 0 0 0 21 24 1 0 0 0 0 21 25 2 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 22 38 1 0 0 0 0 23 26 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 25 27 1 0 0 0 0 25 41 1 0 0 0 0 26 27 2 0 0 0 0 26 42 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 29 45 1 0 0 0 0 M END > (471) 470 > (471) C21H16Cl2N4O2 > (471) 427.289 > (471) FGFR-P470 > (471) PD166326 > (471) FGFR-1 Tyrosine Kinase > (471) 61.5 > (471) BINDDB > (471) <2007 > (471) P > (471) TRAIN $$$$ Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6v csChFnd70/04170815452D 54 58 0 0 0 0 0 0 0 0999 V2000 8.1884 13.0718 -0.8258 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9914 13.0409 -0.5963 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5441 13.8709 -0.8176 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6374 10.6945 -0.4088 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2227 11.4608 -0.6195 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8659 10.5894 -0.6191 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3188 8.4062 -0.2268 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2027 13.7429 -0.5880 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9901 11.5049 -0.4028 N 0 0 3 0 0 0 0 0 0 0 0 0 12.4480 10.6913 -0.1843 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6296 9.1800 -0.2180 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9668 9.0887 -0.4219 N 0 0 0 0 0 0 0 0 0 0 0 0 9.5466 15.5603 -1.0315 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6520 16.1854 -2.5046 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6538 17.7612 -2.6960 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5522 18.7192 -1.4312 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4475 18.1068 0.0322 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4372 16.5329 0.2389 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2974 15.7667 2.0758 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.7809 14.9852 -4.0933 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.3588 6.8322 -0.0252 N 0 0 3 0 0 0 0 0 0 0 0 0 6.9855 6.0022 0.1045 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3672 5.8411 0.9509 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5372 3.7017 -0.3517 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8907 4.5198 -0.4795 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7206 6.6593 0.8226 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2704 4.3611 0.3612 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8801 2.5552 2.1900 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5062 1.1601 -0.0992 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0487 1.9999 -0.2061 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4163 3.4092 2.1064 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8987 3.5315 0.4917 N 0 0 0 0 0 0 0 0 0 0 0 0 1.0382 1.0838 1.4747 O 0 0 0 0 0 0 0 0 0 0 0 0 7.1089 13.6641 -0.9823 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7622 11.1351 -0.7766 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9027 10.3427 -1.2984 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2684 11.4495 0.3828 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2577 9.6766 0.5251 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7353 18.2466 -3.8355 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5550 19.9506 -1.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3684 18.8610 1.0148 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3378 6.3014 0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3822 6.3539 1.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4620 2.5507 -0.8103 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8758 4.0071 -1.0338 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7960 7.8103 1.2811 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5503 2.4041 3.3891 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.2179 1.5936 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6443 1.7822 -0.7621 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6290 0.0000 -0.5557 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9245 1.3456 0.4056 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3778 2.1187 -1.4089 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2839 4.5567 2.5915 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2820 2.7774 2.7549 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 34 1 0 0 0 0 2 9 1 0 0 0 0 2 3 1 0 0 0 0 2 8 2 0 0 0 0 3 13 1 0 0 0 0 4 9 1 0 0 0 0 4 11 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 12 1 0 0 0 0 6 35 1 0 0 0 0 7 12 2 0 0 0 0 7 11 1 0 0 0 0 7 21 1 0 0 0 0 9 10 1 0 0 0 0 10 36 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 13 18 2 0 0 0 0 13 14 1 0 0 0 0 14 15 2 0 0 0 0 14 20 1 0 0 0 0 15 16 1 0 0 0 0 15 39 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 21 22 1 0 0 0 0 21 42 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 43 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 25 45 1 0 0 0 0 26 46 1 0 0 0 0 27 32 1 0 0 0 0 28 33 1 0 0 0 0 28 31 1 0 0 0 0 28 47 1 0 0 0 0 28 48 1 0 0 0 0 29 33 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 29 50 1 0 0 0 0 30 32 1 0 0 0 0 30 51 1 0 0 0 0 30 52 1 0 0 0 0 31 32 1 0 0 0 0 31 53 1 0 0 0 0 31 54 1 0 0 0 0 M END > (473) 472 > (473) C24H21Cl2N5O2 > (473) 482.3682 > (473) FGFR-P472 > (473) PD173952 > (473) FGFR-1 Tyrosine Kinase > (473) 98.8 > (473) BINDDB > (473) <2007 > (473) P > (473) TRAIN $$$$ PD0173955 csChFnd70/04170815452D 45 48 0 0 0 0 0 0 0 0999 V2000 3.4754 18.5580 1.0644 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6268 21.4700 1.6403 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9012 19.6709 1.4484 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7813 19.2730 0.8697 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5249 21.0745 1.0649 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9428 22.1695 1.4525 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0154 18.7956 1.6852 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 17.9012 0.3826 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.7137 8.4137 1.3160 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7414 7.2753 2.7772 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4514 6.7336 5.8311 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8029 5.0281 5.6824 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1260 4.4349 4.0753 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0961 5.5612 2.6205 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4228 7.8574 4.3864 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7603 16.6267 0.8560 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6312 15.5227 2.2899 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1745 15.8805 -0.8869 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2857 16.8526 -2.1706 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4336 14.1249 -1.0775 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8551 13.4003 -2.8284 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4413 10.2080 1.5582 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3138 13.0090 0.3530 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9094 13.6858 2.0495 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7914 12.4989 3.4755 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0632 10.7977 3.1732 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5674 11.2769 0.1723 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6233 1.3645 6.0938 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2998 2.2593 3.8864 S 0 0 0 0 0 0 0 0 0 0 0 0 5.7292 22.3329 1.9374 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2144 21.6297 0.9142 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7353 23.5774 1.6033 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8857 7.9438 0.1319 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9761 7.1914 7.0814 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8273 4.1528 6.8145 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5709 5.1040 1.3702 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9307 9.1898 4.5073 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3219 16.0472 3.5850 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6319 13.0461 -3.5101 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5670 14.3915 -3.6010 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6798 12.2244 -2.6771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4852 12.9672 4.7927 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8844 2.1579 7.0482 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1512 0.0000 6.1342 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0287 1.3978 6.4256 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 30 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 31 1 0 0 0 0 6 32 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 33 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 34 1 0 0 0 0 12 13 2 0 0 0 0 12 35 1 0 0 0 0 13 14 1 0 0 0 0 13 29 1 0 0 0 0 14 36 1 0 0 0 0 15 37 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 38 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 42 1 0 0 0 0 28 29 1 0 0 0 0 28 43 1 0 0 0 0 28 44 1 0 0 0 0 28 45 1 0 0 0 0 M END > (474) 473 > (474) C21H16Cl2N4OS > (474) 443.3496 > (474) FGFR-P473 > (474) PD173955 > (474) FGFR-1 Tyrosine Kinase > (474) 1250 > (474) BINDDB > (474) <2007 > (474) P > (474) TRAIN $$$$ PD0173956 csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.4762 15.4589 1.0746 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6296 18.3698 1.6528 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9030 16.5705 1.4588 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7823 16.1749 0.8821 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5271 17.9767 1.0791 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9459 19.0704 1.4669 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0170 15.6940 1.6934 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.8047 0.3946 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.7149 5.3145 1.3160 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7444 4.1739 2.7776 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4534 3.6264 5.8268 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8042 1.9175 5.6687 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1315 1.3334 4.0643 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1005 2.4571 2.6201 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4249 4.7546 4.3859 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7599 13.5276 0.8642 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6315 12.4222 2.2970 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1726 12.7830 -0.8799 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2834 13.7564 -2.1628 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4307 11.0275 -1.0724 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8500 10.3045 -2.8246 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4416 7.1082 1.5599 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3120 9.9104 0.3571 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9091 10.5856 2.0548 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7924 9.3972 3.4797 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0645 7.6965 3.1759 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5652 8.1782 0.1745 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8333 0.8161 7.0797 F 0 0 0 0 0 0 0 0 0 0 0 0 5.7329 19.2317 1.9502 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2168 18.5326 0.9300 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7394 20.4783 1.6194 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8862 4.8457 0.1315 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9768 4.0794 7.0794 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6258 0.0000 3.9439 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5753 2.0012 1.3692 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9318 6.0874 4.5098 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3230 12.9454 3.5928 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6258 9.9514 -3.5052 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5617 11.2962 -3.5970 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6744 9.1278 -2.6752 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4869 9.8644 4.7975 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 29 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 30 1 0 0 0 0 6 31 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 32 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 33 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 34 1 0 0 0 0 14 35 1 0 0 0 0 15 36 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 37 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 38 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 M END > (475) 474 > (475) C20H13Cl2FN4O > (475) 415.2533 > (475) FGFR-P474 > (475) PD173956 > (475) FGFR-1 Tyrosine Kinase > (475) 933 > (475) BINDDB > (475) <2007 > (475) P > (475) TRAIN $$$$ PD0173958 csChFnd70/04170815452D 48 51 0 0 0 0 0 0 0 0999 V2000 3.5052 18.9263 1.0814 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6681 21.8619 1.6638 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9439 20.0476 1.4688 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7971 19.6483 0.8866 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5396 21.4651 1.0850 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9703 22.5684 1.4753 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0757 19.1638 1.7059 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 18.2664 0.3953 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.7513 8.6967 1.3272 N 0 0 3 0 0 0 0 0 0 0 0 0 4.7801 7.5460 2.8022 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4946 6.9965 5.8777 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8372 5.2707 5.7192 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1582 4.6816 4.0982 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1292 5.8156 2.6427 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4667 8.1321 4.4236 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7916 16.9789 0.8698 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6614 15.8645 2.3149 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2079 16.2277 -0.8886 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3199 17.2089 -2.1825 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4684 14.4573 -1.0822 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8921 13.7278 -2.8487 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4769 10.5055 1.5729 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3477 13.3310 0.3594 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9411 14.0123 2.0709 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8231 12.8144 3.5082 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0969 11.0992 3.2022 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6025 11.5842 0.1757 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8652 4.1531 7.1518 O 0 0 0 0 0 0 0 0 0 0 0 0 4.1668 2.3948 6.8935 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3102 1.3412 8.6397 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7804 22.7313 1.9636 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2182 22.0257 0.9346 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7618 23.9880 1.6291 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9238 8.2236 0.1328 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0227 7.4542 7.1405 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6466 3.3377 3.9760 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6001 5.3570 1.3807 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9790 9.4756 4.5471 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3507 16.3926 3.6216 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6580 13.3717 -3.5357 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6102 14.7276 -3.6275 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7232 12.5414 -2.6975 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5151 13.2858 4.8370 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7694 2.4815 6.4922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9294 1.7173 5.8538 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7774 0.0000 8.4428 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7076 1.2545 9.0411 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5475 2.0187 9.6795 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 31 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 32 1 0 0 0 0 6 33 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 34 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 35 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 36 1 0 0 0 0 14 37 1 0 0 0 0 15 38 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 39 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 40 1 0 0 0 0 21 41 1 0 0 0 0 21 42 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 43 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 44 1 0 0 0 0 29 45 1 0 0 0 0 30 46 1 0 0 0 0 30 47 1 0 0 0 0 30 48 1 0 0 0 0 M END > (476) 475 > (476) C22H18Cl2N4O2 > (476) 441.3158 > (476) FGFR-P475 > (476) PD173958 > (476) FGFR-1 Tyrosine Kinase > (476) 451 > (476) BINDDB > (476) <2007 > (476) P > (476) TRAIN $$$$ PD0179483 csChFnd70/04170815452D 61 64 0 0 0 0 0 0 0 0999 V2000 4.1228 19.8990 -0.1529 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7760 23.0775 0.5129 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8187 21.5168 0.5511 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3786 19.8712 -0.8979 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3500 21.4415 -0.9275 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0455 23.0392 -0.2216 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9901 21.5677 1.4733 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1.5039 17.8676 -1.7860 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.3271 10.9093 1.2785 N 0 0 3 0 0 0 0 0 0 0 0 0 9.3751 9.7800 2.8098 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2844 9.4115 6.0475 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4698 7.5469 5.8377 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6155 6.8012 4.1121 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5684 7.9140 2.6012 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2371 10.5262 4.5380 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2340 18.2198 -0.1173 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1431 17.0646 1.3390 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4333 17.7765 -1.6430 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5176 18.7937 -2.9469 O 0 0 0 0 0 0 0 0 0 0 0 0 7.4439 16.2504 -1.6117 N 0 0 3 0 0 0 0 0 0 0 0 0 8.6431 15.8308 -3.1449 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2729 12.4631 1.2905 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3671 15.0883 -0.1551 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2190 15.4727 1.3339 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1751 14.2454 2.7928 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2086 12.7812 2.7143 N 0 0 0 0 0 0 0 0 0 0 0 0 8.3603 13.5811 -0.1176 N 0 0 0 0 0 0 0 0 0 0 0 0 9.5163 6.4501 7.3248 O 0 0 0 0 0 0 0 0 0 0 0 0 9.7099 4.5434 7.0086 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7347 3.5379 8.8288 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9696 3.7465 9.7266 N 0 0 3 0 0 0 0 0 0 0 0 0 6.5206 2.4219 9.3938 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5355 0.9857 10.8979 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6788 5.1572 10.8587 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8197 5.4572 11.6647 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9134 6.1852 11.2289 O 0 0 0 0 0 0 0 0 0 0 0 0 4.3130 24.3307 1.0574 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 21.4219 -1.5036 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2357 24.2634 -0.2481 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0341 10.6006 0.2093 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1706 9.9910 7.3915 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7599 5.3494 3.9498 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6815 7.3332 1.2577 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0932 11.9779 4.7017 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2630 17.3654 2.4748 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9047 15.0216 -4.1425 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1010 17.0920 -3.7735 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8161 15.0666 -2.6600 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3142 14.4938 3.9555 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5714 4.0601 6.1929 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9781 4.2889 6.2863 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0030 2.0996 8.5949 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7977 4.1046 9.6915 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2108 3.1143 9.3853 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7415 1.7668 8.0834 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8453 0.2932 10.9066 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3145 1.6407 12.2084 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4572 0.0000 10.6503 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9283 4.3378 11.2807 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9257 5.5198 13.1412 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2604 6.7311 11.1553 H 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 37 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 38 1 0 0 0 0 6 39 1 0 0 0 0 9 22 1 0 0 0 0 9 10 1 0 0 0 0 9 40 1 0 0 0 0 10 14 2 0 0 0 0 10 15 1 0 0 0 0 11 12 1 0 0 0 0 11 15 2 0 0 0 0 11 41 1 0 0 0 0 12 13 2 0 0 0 0 12 28 1 0 0 0 0 13 14 1 0 0 0 0 13 42 1 0 0 0 0 14 43 1 0 0 0 0 15 44 1 0 0 0 0 16 18 1 0 0 0 0 16 17 2 0 0 0 0 17 24 1 0 0 0 0 17 45 1 0 0 0 0 18 20 1 0 0 0 0 18 19 2 0 0 0 0 20 23 1 0 0 0 0 20 21 1 0 0 0 0 21 46 1 0 0 0 0 21 47 1 0 0 0 0 21 48 1 0 0 0 0 22 26 2 0 0 0 0 22 27 1 0 0 0 0 23 27 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 25 49 1 0 0 0 0 28 29 1 0 0 0 0 29 30 1 0 0 0 0 29 50 1 0 0 0 0 29 51 1 0 0 0 0 30 31 1 0 0 0 0 30 52 1 0 0 0 0 30 53 1 0 0 0 0 31 32 1 0 0 0 0 31 34 1 0 0 0 0 32 33 1 0 0 0 0 32 54 1 0 0 0 0 32 55 1 0 0 0 0 33 56 1 0 0 0 0 33 57 1 0 0 0 0 33 58 1 0 0 0 0 34 35 1 0 0 0 0 34 36 2 0 0 0 0 35 59 1 0 0 0 0 35 60 1 0 0 0 0 35 61 1 0 0 0 0 M END > (477) 476 > (477) C26H25Cl2N5O3 > (477) 526.4212 > (477) FGFR-P476 > (477) PD179483 > (477) FGFR-1 Tyrosine Kinase > (477) 244 > (477) BINDDB > (477) <2007 > (477) P > (477) TRAIN $$$$ PD0180970 csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 3.5290 14.6070 -0.2841 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0800 17.3290 -0.5179 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0949 15.5238 -0.4729 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9563 15.5216 -0.1487 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9595 17.3269 -0.1955 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5171 18.2280 -0.3760 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0577 14.3980 -0.6505 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 14.3933 0.0773 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.5353 12.6705 -0.2356 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6934 11.8068 1.3243 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3646 11.6631 -1.8548 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2174 12.4212 -3.2478 O 0 0 0 0 0 0 0 0 0 0 0 0 3.3703 9.9028 -1.8117 N 0 0 3 0 0 0 0 0 0 0 0 0 3.2065 8.9140 -3.4441 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7032 4.6474 1.2984 N 0 0 3 0 0 0 0 0 0 0 0 0 4.0109 3.7304 2.8511 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1858 2.1398 3.1467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4922 1.2366 4.6798 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6204 1.9160 5.9224 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4439 3.5015 5.6307 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1476 4.4053 4.0954 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6700 4.2380 6.9857 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9177 1.0307 7.4216 F 0 0 0 0 0 0 0 0 0 0 0 0 3.6951 9.9585 1.3287 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5355 9.0260 -0.2555 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8547 9.0118 2.8923 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7019 6.4536 1.3012 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5419 7.2897 -0.2059 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8496 7.2881 2.8180 N 0 0 0 0 0 0 0 0 0 0 0 0 6.2911 18.0401 -0.6635 H 0 0 0 0 0 0 0 0 0 0 0 0 0.7432 18.0364 -0.0913 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5126 19.6396 -0.4119 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8153 12.5264 2.5330 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8293 8.6621 -3.7108 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7675 9.6686 -4.5148 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9008 7.6755 -3.3210 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4906 4.0148 0.2199 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3051 1.6101 2.1785 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8509 0.0000 4.9102 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7951 5.6390 3.8657 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9934 3.7748 6.7308 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6452 5.6616 6.9251 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2584 3.8103 8.2814 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9795 9.6796 4.1301 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 3 2 0 0 0 0 1 4 1 0 0 0 0 2 3 1 0 0 0 0 2 6 2 0 0 0 0 2 30 1 0 0 0 0 3 7 1 0 0 0 0 4 5 2 0 0 0 0 4 8 1 0 0 0 0 5 6 1 0 0 0 0 5 31 1 0 0 0 0 6 32 1 0 0 0 0 9 11 1 0 0 0 0 9 10 2 0 0 0 0 10 24 1 0 0 0 0 10 33 1 0 0 0 0 11 13 1 0 0 0 0 11 12 2 0 0 0 0 13 25 1 0 0 0 0 13 14 1 0 0 0 0 14 34 1 0 0 0 0 14 35 1 0 0 0 0 14 36 1 0 0 0 0 15 16 1 0 0 0 0 15 27 1 0 0 0 0 15 37 1 0 0 0 0 16 17 1 0 0 0 0 16 21 2 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 19 1 0 0 0 0 18 39 1 0 0 0 0 19 20 2 0 0 0 0 19 23 1 0 0 0 0 20 21 1 0 0 0 0 20 22 1 0 0 0 0 21 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 24 26 1 0 0 0 0 24 25 2 0 0 0 0 25 28 1 0 0 0 0 26 29 2 0 0 0 0 26 44 1 0 0 0 0 27 29 1 0 0 0 0 27 28 2 0 0 0 0 M END > (478) 477 > (478) C21H15Cl2FN4O > (478) 429.2801 > (478) FGFR-P477 > (478) PD180970 > (478) FGFR-1 Tyrosine Kinase > (478) 934 > (478) BINDDB > (478) <2007 > (478) P > (478) TRAIN $$$$ 1,6-naphthyridin 34 csChFnd70/04170815452D 72 75 0 0 0 0 0 0 0 0999 V2000 1.2228 16.2729 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7134 13.6637 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3130 14.4680 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7814 17.2074 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3767 16.2866 -0.0180 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8075 19.0303 0.0110 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9357 18.8481 -0.0203 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4042 19.8506 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2458 14.5704 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8822 17.1423 -0.0284 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5052 21.7699 0.0076 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6625 24.4576 1.5738 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5678 22.6694 1.5751 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5455 22.6835 -1.5524 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6403 24.4717 -1.5362 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6957 25.3563 0.0225 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6344 11.8633 -0.0258 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2361 10.8426 -0.0464 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7885 8.9101 -0.0533 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4612 7.8442 -0.0749 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4776 21.5756 -3.5103 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5262 21.5437 3.5237 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6902 5.5942 1.2125 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2065 3.6736 1.0939 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1032 3.0062 0.0882 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5868 4.9269 0.2068 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0316 5.9889 -0.0815 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7619 2.6115 1.3822 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3323 0.7562 1.3756 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5323 19.6791 -0.0316 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0057 18.7404 -0.0507 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9368 17.1658 -0.0579 O 0 0 0 0 0 0 0 0 0 0 0 0 10.5556 19.5471 -0.0617 N 0 0 3 0 0 0 0 0 0 0 0 0 12.1573 18.5266 -0.0823 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1967 17.3908 -1.7080 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7197 19.7485 -0.0914 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2281 17.3746 1.5308 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9546 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4916 13.7126 -0.0419 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6178 19.7683 0.0258 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7110 25.1556 2.7866 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6715 25.1806 -2.7433 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7697 26.7544 0.0284 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5190 11.2828 -0.0187 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9805 11.1578 -1.2054 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0020 11.1447 1.1019 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0441 8.5950 1.1057 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0226 8.6081 -1.2018 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2057 8.1595 -1.2339 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2271 8.1463 1.0735 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5460 6.3847 0.9619 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1850 5.8767 2.5057 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2389 3.3693 2.0777 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6789 3.3985 -0.1878 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6084 2.7236 -1.2049 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2472 2.2157 0.3389 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1145 5.2020 1.4885 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5543 5.2312 -0.7771 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7704 0.4072 0.1269 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5063 0.0000 1.5917 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4012 0.4846 2.4034 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5871 20.9355 -0.0259 H 0 0 0 0 0 0 0 0 0 0 0 0 10.6106 20.8033 -0.0559 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1462 18.2116 -2.8573 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3884 16.6316 -1.7234 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0836 16.5203 -1.7017 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6916 20.5575 1.0667 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9114 18.9892 -0.1068 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6692 20.5691 -1.2407 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1150 16.5040 1.5373 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4197 16.6152 1.5154 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2001 18.1837 2.6890 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 38 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 39 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 40 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 30 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 41 1 0 0 0 0 13 22 1 0 0 0 0 14 15 1 0 0 0 0 14 21 1 0 0 0 0 15 16 2 0 0 0 0 15 42 1 0 0 0 0 16 43 1 0 0 0 0 17 18 1 0 0 0 0 17 44 1 0 0 0 0 18 19 1 0 0 0 0 18 45 1 0 0 0 0 18 46 1 0 0 0 0 19 20 1 0 0 0 0 19 47 1 0 0 0 0 19 48 1 0 0 0 0 20 27 1 0 0 0 0 20 49 1 0 0 0 0 20 50 1 0 0 0 0 23 27 1 0 0 0 0 23 24 1 0 0 0 0 23 51 1 0 0 0 0 23 52 1 0 0 0 0 24 28 1 0 0 0 0 24 53 1 0 0 0 0 24 54 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 25 55 1 0 0 0 0 25 56 1 0 0 0 0 26 27 1 0 0 0 0 26 57 1 0 0 0 0 26 58 1 0 0 0 0 28 29 1 0 0 0 0 29 59 1 0 0 0 0 29 60 1 0 0 0 0 29 61 1 0 0 0 0 30 31 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 31 33 1 0 0 0 0 33 34 1 0 0 0 0 33 63 1 0 0 0 0 34 35 1 0 0 0 0 34 36 1 0 0 0 0 34 37 1 0 0 0 0 35 64 1 0 0 0 0 35 65 1 0 0 0 0 35 66 1 0 0 0 0 36 67 1 0 0 0 0 36 68 1 0 0 0 0 36 69 1 0 0 0 0 37 70 1 0 0 0 0 37 71 1 0 0 0 0 37 72 1 0 0 0 0 M END > (49) 47 > (49) C27H35Cl2N7O > (49) 544.5258 > (49) FGFR-P47 > (49) 1,6-naphthyridine 34 > (49) FGFR-1 Tyrosine Kinase > (49) 26 > (49) BINDDB > (49) <2007 > (49) P > (49) TRAIN $$$$ Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6w csChFnd70/04170815452D 57 60 0 0 0 0 0 0 0 0999 V2000 8.0775 14.2102 -4.3465 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0261 14.6700 -4.4135 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3556 15.2069 -4.7489 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0306 12.2016 -3.3081 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4063 12.6834 -3.6154 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1401 11.6174 -3.1808 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0618 9.7944 -2.2313 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1702 15.5494 -4.7671 O 0 0 0 0 0 0 0 0 0 0 0 0 11.3037 13.2088 -3.7155 N 0 0 3 0 0 0 0 0 0 0 0 0 12.9819 12.6893 -3.3886 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2974 10.7597 -2.6192 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5188 10.2073 -2.5023 N 0 0 0 0 0 0 0 0 0 0 0 0 9.0516 16.8140 -5.5172 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9680 16.9493 -7.2120 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6844 18.4513 -7.9204 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4831 19.8196 -6.9540 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5644 19.6940 -5.2733 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8404 18.1980 -4.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9332 18.0415 -2.4395 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.2211 15.2336 -8.4270 Cl 0 0 0 0 0 0 0 0 0 0 0 0 9.3900 8.3025 -1.5176 N 0 0 3 0 0 0 0 0 0 0 0 0 8.1125 7.2887 -1.0434 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4123 6.9634 0.0338 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0158 4.5981 -0.7030 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2764 5.6035 -1.1706 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6770 7.9623 -0.4366 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5702 5.2709 -0.0990 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2166 4.1966 0.4039 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4316 4.5135 1.6217 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5689 1.7466 0.0632 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9536 2.2032 -0.7527 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8504 2.8641 -0.4865 N 0 0 0 0 0 0 0 0 0 0 0 0 4.7342 2.5328 -2.0039 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9542 1.1486 -1.7239 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8369 14.5869 -4.5793 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8821 11.9440 -3.3963 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4549 12.0298 -4.4418 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7394 13.7572 -3.1577 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0002 11.8942 -2.3232 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6200 18.5576 -9.2320 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2619 20.9912 -7.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4065 20.7670 -4.5256 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5102 7.9618 -1.3471 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2969 7.4870 0.4999 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1415 3.2909 -0.8075 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3936 5.0844 -1.6373 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5557 9.2699 -0.3342 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4392 1.8360 1.3835 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8955 0.5009 -0.2668 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6270 3.4489 -0.4228 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0833 2.1138 -2.0729 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.3718 -0.3437 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8711 2.1781 -2.9510 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3857 3.6272 -2.3853 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6540 1.3912 -0.6198 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2981 0.0000 -1.5894 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7797 1.0683 -2.7631 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 35 1 0 0 0 0 2 9 1 0 0 0 0 2 3 1 0 0 0 0 2 8 2 0 0 0 0 3 13 1 0 0 0 0 4 9 1 0 0 0 0 4 11 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 12 1 0 0 0 0 6 36 1 0 0 0 0 7 12 2 0 0 0 0 7 11 1 0 0 0 0 7 21 1 0 0 0 0 9 10 1 0 0 0 0 10 37 1 0 0 0 0 10 38 1 0 0 0 0 10 39 1 0 0 0 0 13 18 2 0 0 0 0 13 14 1 0 0 0 0 14 15 2 0 0 0 0 14 20 1 0 0 0 0 15 16 1 0 0 0 0 15 40 1 0 0 0 0 16 17 2 0 0 0 0 16 41 1 0 0 0 0 17 18 1 0 0 0 0 17 42 1 0 0 0 0 18 19 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 22 25 2 0 0 0 0 22 26 1 0 0 0 0 23 27 1 0 0 0 0 23 26 2 0 0 0 0 23 44 1 0 0 0 0 24 27 2 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 25 46 1 0 0 0 0 26 47 1 0 0 0 0 27 28 1 0 0 0 0 28 32 1 0 0 0 0 28 29 2 0 0 0 0 30 32 1 0 0 0 0 30 31 1 0 0 0 0 30 48 1 0 0 0 0 30 49 1 0 0 0 0 31 50 1 0 0 0 0 31 51 1 0 0 0 0 31 52 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 53 1 0 0 0 0 33 54 1 0 0 0 0 34 55 1 0 0 0 0 34 56 1 0 0 0 0 34 57 1 0 0 0 0 M END > (487) 486 > (487) C25H23Cl2N5O2 > (487) 496.395 > (487) FGFR-P486 > (487) Pyrido[2,3-d]pyrimidin-7(8H)-one deriv. 6w > (487) FGFR-1 Tyrosine Kinase > (487) 180 > (487) BINDDB > (487) <2007 > (487) P > (487) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 10 csChFnd70/04170815452D 46 48 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0300 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7215 2.4478 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7977 5.9219 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3487 4.9511 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7535 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0196 7.5176 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 8.5637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3191 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2483 3.2321 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4298 8.2279 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9251 5.7742 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5407 10.4812 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7027 13.1674 1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3798 1.5792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 11.3961 -1.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6816 13.1836 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0670 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5608 10.2533 3.5267 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2900 -3.5076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6713 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5220 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0525 4.4041 -1.8970 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1858 4.9611 -3.0767 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4881 3.4801 -2.2332 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9203 3.2009 -4.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1921 4.9511 -4.9359 C 0 0 0 0 0 0 0 0 0 0 0 0 11.5847 2.1296 -4.1684 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4395 2.2277 -4.9343 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7283 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6737 8.5023 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7520 13.8646 2.7919 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7154 13.8933 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8140 15.4647 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7422 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5484 5.4583 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2998 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2472 5.6444 -4.3013 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5166 4.7416 -6.2949 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0063 5.7143 -4.8470 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3911 0.8828 -3.5328 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9091 1.9201 -5.5275 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6397 2.8230 -3.5339 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2536 2.9909 -4.8455 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7639 2.0181 -6.2935 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2458 0.9808 -4.2987 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 29 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 30 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 31 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 33 1 0 0 0 0 20 34 1 0 0 0 0 20 35 1 0 0 0 0 21 22 1 0 0 0 0 21 36 1 0 0 0 0 21 37 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 25 28 1 0 0 0 0 26 38 1 0 0 0 0 26 39 1 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 27 42 1 0 0 0 0 27 43 1 0 0 0 0 28 44 1 0 0 0 0 28 45 1 0 0 0 0 28 46 1 0 0 0 0 M END > (488) 487 > (488) C19H18Cl2N4O3 > (488) 421.2822 > (488) FGFR-P487 > (488) pyrido[2,3-d]pyrimidin-7-one deriv. 10 > (488) FGFR-1 Tyrosine Kinase > (488) 1700 > (488) BINDDB > (488) <2007 > (488) P > (488) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 12 csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0300 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7215 2.4478 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7977 5.9219 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3487 4.9511 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7535 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0196 7.5176 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 8.5637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3191 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2483 3.2321 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4298 8.2279 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9251 5.7742 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5407 10.4812 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7027 13.1674 1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3798 1.5792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 11.3961 -1.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6816 13.1836 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0670 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5608 10.2533 3.5267 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2900 -3.5076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6713 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5220 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0525 4.4041 -1.8970 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1358 5.5519 -2.7456 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4621 2.9382 -2.7417 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9488 2.6240 -4.4374 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0256 3.7760 -5.2886 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6224 5.2378 -4.4413 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7283 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6737 8.5023 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7520 13.8646 2.7919 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7154 13.8933 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8140 15.4647 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7422 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5484 5.4583 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2998 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6014 6.6944 -2.0838 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6208 2.0382 -2.0768 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4881 1.4783 -5.0970 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4062 3.5302 -6.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4684 6.1348 -5.1044 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 30 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 20 33 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 27 1 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 26 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 27 41 1 0 0 0 0 M END > (490) 489 > (490) C20H14Cl2N4O > (490) 397.2628 > (490) FGFR-P489 > (490) pyrido[2,3-d]pyrimidin-7-one deriv. 12 > (490) FGFR-1 Tyrosine Kinase > (490) 1400 > (490) BINDDB > (490) <2007 > (490) P > (490) TRAIN $$$$ 1,6-naphthyridin 35 csChFnd70/04170815452D 56 58 0 0 0 0 0 0 0 0999 V2000 1.1422 15.4389 0.5800 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3665 12.6682 0.3628 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0236 13.3205 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7712 16.2256 0.2652 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2598 15.1432 -0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9702 18.0571 0.2162 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0442 17.5674 -0.3670 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6250 18.7262 -0.1035 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0026 13.7243 0.6164 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8291 15.8561 -0.3156 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9063 20.6467 -0.1694 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5960 23.3535 1.2816 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3349 21.5642 1.3519 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7510 21.5429 -1.7545 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0153 23.3324 -1.8074 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4333 24.2356 -0.2931 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1170 10.8650 0.4205 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6024 9.6814 0.1445 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9763 7.7817 0.2747 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2271 20.4117 -3.6568 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.5391 20.4596 3.3295 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.6951 18.2449 -0.6858 N 0 0 0 0 0 0 0 0 0 0 0 0 4.5275 6.5455 -0.0136 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9015 4.6459 0.1166 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3909 3.4591 -0.1602 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6731 3.6172 1.2662 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4002 2.7657 0.7096 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7958 1.6391 -0.3541 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0105 1.3839 -2.1806 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.2447 0.7989 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1165 12.4451 -0.1596 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8643 18.9156 0.4212 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9280 24.0653 2.4584 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8959 24.0278 -3.0338 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6388 25.6346 -0.3412 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9594 10.3904 0.6438 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1600 9.9112 -1.1499 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5963 9.9243 1.1408 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4187 7.5519 1.5691 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9826 7.5387 -0.7216 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6789 17.4614 -0.8687 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8687 19.5031 -0.7266 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0852 6.7753 -1.3080 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5214 6.7885 0.9827 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3439 4.4161 1.4110 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9078 4.4029 -0.8797 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8949 4.9977 1.5560 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1725 2.9607 2.4313 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1664 1.4021 0.3556 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9348 3.4645 -0.4152 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3302 2.8237 1.7918 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9047 0.7553 -0.1850 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8052 1.3544 0.6341 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9428 1.8300 -3.1662 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7254 0.0000 -2.3869 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8040 2.1399 -2.2898 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 32 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 22 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 33 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 34 1 0 0 0 0 16 35 1 0 0 0 0 17 18 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 18 37 1 0 0 0 0 18 38 1 0 0 0 0 19 23 1 0 0 0 0 19 39 1 0 0 0 0 19 40 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 M END > (50) 48 > (50) C22H27Cl2N5 > (50) 432.3948 > (50) FGFR-P48 > (50) 1,6-naphthyridine 35 > (50) FGFR-1 Tyrosine Kinase > (50) 350 > (50) BINDDB > (50) <2007 > (50) P > (50) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 13 csChFnd70/04170815452D 40 43 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0300 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7215 2.4478 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7977 5.9219 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3487 4.9511 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7535 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0196 7.5176 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 8.5637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3191 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2483 3.2321 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4298 8.2279 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9251 5.7742 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5407 10.4812 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7027 13.1674 1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3798 1.5792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 11.3961 -1.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6816 13.1836 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0670 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5608 10.2533 3.5267 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2900 -3.5076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6713 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5220 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0525 4.4041 -1.8970 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1380 5.5411 -2.7684 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4728 2.9406 -2.7645 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9867 2.6695 -4.4593 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5969 5.1843 -4.4629 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0153 3.7826 -5.2497 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7283 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6737 8.5023 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7520 13.8646 2.7919 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7154 13.8933 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8140 15.4647 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7422 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5484 5.4583 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2998 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6185 6.6912 -2.1310 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6309 2.0238 -2.1238 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5408 1.5328 -5.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4415 6.0638 -5.1508 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 29 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 30 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 20 33 1 0 0 0 0 20 34 1 0 0 0 0 21 22 1 0 0 0 0 21 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 25 2 0 0 0 0 24 38 1 0 0 0 0 25 27 1 0 0 0 0 25 39 1 0 0 0 0 26 27 2 0 0 0 0 26 40 1 0 0 0 0 M END > (491) 490 > (491) C19H13Cl2N5O > (491) 398.2506 > (491) FGFR-P490 > (491) pyrido[2,3-d]pyrimidin-7-one deriv. 13 > (491) FGFR-1 Tyrosine Kinase > (491) 720 > (491) BINDDB > (491) <2007 > (491) P > (491) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 14 csChFnd70/04170815452D 45 47 0 0 0 0 0 0 0 0999 V2000 1.2134 5.0308 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7219 2.4482 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7981 5.9229 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3493 4.9518 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8570 7.7546 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0205 7.5187 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4361 8.5649 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2366 3.3196 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2489 3.2326 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4309 8.2291 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9260 5.7751 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5414 10.4828 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7034 13.1694 1.5791 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6055 11.3815 1.5795 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5843 11.3978 -1.5493 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6823 13.1856 -1.5315 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7380 14.0692 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5615 10.2549 3.5273 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5153 10.2916 -3.5081 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6717 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5231 4.7472 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0619 4.3995 -1.9256 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7298 3.3261 -1.9466 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2471 2.9921 -3.7488 N 0 0 0 0 0 0 0 0 0 0 0 0 11.9932 2.2356 -3.8287 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9788 1.8757 -4.6273 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7292 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6740 8.5036 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7527 13.8667 2.7923 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7161 13.8955 -2.7380 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8147 15.4671 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5656 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7427 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5496 5.4591 0.6121 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3009 3.5186 0.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0352 3.6876 -2.5862 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2841 5.6282 -2.5872 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7565 4.0378 -1.2861 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5076 2.0974 -1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0100 1.0140 -3.1186 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3437 2.0015 -5.1774 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9210 3.1302 -3.2493 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7152 2.5085 -4.6285 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3932 1.6491 -5.9592 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8865 0.6410 -3.9462 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 28 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 29 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 30 1 0 0 0 0 17 31 1 0 0 0 0 20 32 1 0 0 0 0 20 33 1 0 0 0 0 21 22 1 0 0 0 0 21 34 1 0 0 0 0 21 35 1 0 0 0 0 22 23 1 0 0 0 0 22 36 1 0 0 0 0 22 37 1 0 0 0 0 23 24 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 24 25 1 0 0 0 0 24 26 1 0 0 0 0 25 40 1 0 0 0 0 25 41 1 0 0 0 0 25 42 1 0 0 0 0 26 43 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 M END > (492) 491 > (492) C18H19Cl2N5O > (492) 392.287 > (492) FGFR-P491 > (492) pyrido[2,3-d]pyrimidin-7-one deriv. 14 > (492) FGFR-1 Tyrosine Kinase > (492) 880 > (492) BINDDB > (492) <2007 > (492) P > (492) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 15 csChFnd70/04170815452D 51 54 0 0 0 0 0 0 0 0999 V2000 1.3382 6.7037 0.0133 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0020 3.8554 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0861 7.6877 0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7970 6.6166 -0.0202 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1510 9.7079 0.0127 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6401 9.4477 -0.0213 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8927 10.6016 0.0016 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3638 4.8165 0.0029 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6862 4.7205 -0.0293 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1957 10.2313 -0.0315 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5358 7.5247 -0.0313 N 0 0 3 0 0 0 0 0 0 0 0 0 5.0088 12.7168 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1875 15.6799 1.7416 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0795 13.7080 1.7421 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0561 13.7261 -1.7088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1642 15.6978 -1.6892 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2257 16.6723 0.0310 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0309 12.4654 3.8903 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.9800 12.5059 -3.8691 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.9467 1.8821 -0.0280 N 0 0 0 0 0 0 0 0 0 0 0 0 8.2973 6.3910 -0.0535 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8916 6.0075 -2.1238 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7312 4.8236 -2.1470 C 0 0 0 0 0 0 0 0 0 0 0 0 11.2862 4.4654 -4.0804 O 0 0 0 0 0 0 0 0 0 0 0 0 12.9975 3.3639 -4.2634 C 0 0 0 0 0 0 0 0 0 0 0 0 13.4457 3.0744 -6.3512 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5775 4.3810 -7.3096 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7314 1.4979 -7.3059 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1424 1.2322 -9.2209 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2671 2.5435 -10.1815 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9885 4.1155 -9.2246 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 7.4740 0.0366 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8463 10.5340 0.0292 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2418 16.4490 3.0797 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2015 16.4807 -3.0198 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3102 18.2141 0.0385 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7267 1.2224 -0.0199 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1279 1.1552 -0.0432 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4295 7.1761 0.6750 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0523 5.0359 0.6762 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7593 5.2224 -2.8523 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1367 7.3627 -2.8535 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8635 5.6086 -1.4184 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4861 3.4685 -1.4171 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1767 4.1186 -3.5787 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7994 1.9784 -3.5775 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1403 5.6096 -6.5621 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8527 0.4734 -6.5554 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5852 0.0000 -9.9665 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5887 2.3357 -11.6776 H 0 0 0 0 0 0 0 0 0 0 0 0 15.8725 5.1366 -9.9734 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 32 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 33 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 34 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 20 37 1 0 0 0 0 20 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 45 1 0 0 0 0 25 46 1 0 0 0 0 26 27 2 0 0 0 0 26 28 1 0 0 0 0 27 31 1 0 0 0 0 27 47 1 0 0 0 0 28 29 2 0 0 0 0 28 48 1 0 0 0 0 29 30 1 0 0 0 0 29 49 1 0 0 0 0 30 31 2 0 0 0 0 30 50 1 0 0 0 0 31 51 1 0 0 0 0 M END > (493) 492 > (493) C23H20Cl2N4O2 > (493) 455.3426 > (493) FGFR-P492 > (493) pyrido[2,3-d]pyrimidin-7-one deriv. 15 > (493) FGFR-1 Tyrosine Kinase > (493) 3200 > (493) BINDDB > (493) <2007 > (493) P > (493) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 16 csChFnd70/04170815452D 38 40 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7218 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9226 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9516 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8569 7.7543 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0202 7.5183 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4359 8.5645 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2487 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2287 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9257 5.7748 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4823 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7032 13.1688 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6053 11.3809 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3973 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6821 13.1850 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7378 14.0685 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2543 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5151 10.2910 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5227 4.7470 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0615 4.3993 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7293 3.3259 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2326 3.0012 -3.6995 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7289 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5032 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7525 13.8660 2.7922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7159 13.8948 -2.7379 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4664 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7426 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5492 5.4589 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3005 3.5184 0.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0349 3.6875 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2837 5.6279 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7559 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5071 2.0973 -1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2825 2.3253 -3.8118 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 M END > (494) 493 > (494) C16H14Cl2N4O2 > (494) 365.2182 > (494) FGFR-P493 > (494) pyrido[2,3-d]pyrimidin-7-one deriv. 16 > (494) FGFR-1 Tyrosine Kinase > (494) 370 > (494) BINDDB > (494) <2007 > (494) P > (494) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 24 csChFnd70/04170815452D 41 44 0 0 0 0 0 0 0 0999 V2000 3.8870 7.8204 -0.6062 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2144 5.6142 -0.2208 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2566 8.6144 -0.6078 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6100 7.7994 -0.4014 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2950 10.1961 -0.8100 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0430 10.0403 -0.5853 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6605 10.9193 -0.8022 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9188 6.3440 -0.4119 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5346 6.3144 -0.2138 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2624 10.6748 -0.5764 O 0 0 0 0 0 0 0 0 0 0 0 0 7.9730 8.5340 -0.3952 N 0 0 3 0 0 0 0 0 0 0 0 0 6.7386 12.5763 -1.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1876 15.0811 -0.1381 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1115 13.5389 0.0634 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4452 13.1794 -2.2821 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5143 14.7234 -2.4713 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8849 15.6727 -1.4035 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3665 7.6710 -0.1790 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1832 4.0682 -0.0216 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8018 3.3173 0.1072 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6401 1.8666 -0.4639 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2738 1.1279 -0.3349 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0673 1.8313 0.3614 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2243 3.2758 0.9309 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5897 4.0179 0.8123 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8283 8.4056 -0.7559 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2630 10.8247 -0.9688 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7020 15.8280 0.6937 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5668 13.0786 1.0518 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9377 12.4394 -3.1161 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0613 15.1918 -3.4545 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9418 16.8805 -1.5564 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7977 7.3078 -1.2723 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2047 8.3784 0.3779 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1340 6.6846 0.5183 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1197 3.5040 0.0290 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5816 1.3169 -1.0086 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1474 0.0000 -0.7788 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2514 0.4606 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2796 3.8222 1.4735 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7132 5.1437 1.2624 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 19 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 27 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 18 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 28 1 0 0 0 0 14 29 1 0 0 0 0 15 16 1 0 0 0 0 15 30 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 18 33 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 20 1 0 0 0 0 19 36 1 0 0 0 0 20 21 2 0 0 0 0 20 25 1 0 0 0 0 21 22 1 0 0 0 0 21 37 1 0 0 0 0 22 23 2 0 0 0 0 22 38 1 0 0 0 0 23 24 1 0 0 0 0 23 39 1 0 0 0 0 24 25 2 0 0 0 0 24 40 1 0 0 0 0 25 41 1 0 0 0 0 M END > (495) 494 > (495) C20H16N4O > (495) 328.3726 > (495) FGFR-P494 > (495) pyrido[2,3-d]pyrimidin-7-one deriv. 24 > (495) FGFR-1 Tyrosine Kinase > (495) 5000 > (495) BINDDB > (495) <2007 > (495) P > (495) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 26 csChFnd70/04170815452D 40 43 0 0 0 0 0 0 0 0999 V2000 3.6619 7.9005 -0.5637 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0071 5.6590 -0.2065 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0510 8.7035 -0.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4229 7.8738 -0.3735 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0907 10.3086 -0.7533 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8768 10.1448 -0.5455 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1134 10.7861 -0.5388 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4753 11.0396 -0.7467 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8052 8.6164 -0.3685 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3458 6.3667 -0.1998 N 0 0 0 0 0 0 0 0 0 0 0 0 3.6939 6.4020 -0.3837 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9747 4.0892 -0.0224 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5790 3.3306 0.1072 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3937 1.8546 -0.4676 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9941 1.1431 -0.3159 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9721 3.2354 0.9263 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3334 4.0252 0.8209 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2177 7.7377 -0.1685 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5553 12.7210 -0.9420 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0061 15.2508 -0.0261 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9282 13.6859 0.1622 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2637 13.3449 -2.2275 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3345 14.9116 -2.4031 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7045 15.8629 -1.3070 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8404 1.8416 0.3619 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5889 8.4962 -0.7020 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0445 10.9485 -0.9005 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9235 3.5156 0.0167 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3328 1.2768 -1.0243 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8402 0.0000 -0.7577 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7664 1.4727 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4335 5.1655 1.2851 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6466 7.3812 -1.2833 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0717 8.4474 0.3979 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9855 6.7308 0.5288 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5208 15.9993 0.8282 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3822 13.2094 1.1624 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7561 12.6033 -3.0838 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8832 15.3962 -3.3979 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7631 17.0885 -1.4493 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 27 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 28 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 29 1 0 0 0 0 15 25 2 0 0 0 0 15 30 1 0 0 0 0 16 25 1 0 0 0 0 16 17 2 0 0 0 0 16 31 1 0 0 0 0 17 32 1 0 0 0 0 18 33 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 36 1 0 0 0 0 21 37 1 0 0 0 0 22 23 1 0 0 0 0 22 38 1 0 0 0 0 23 24 2 0 0 0 0 23 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (497) 496 > (497) C19H15N5O > (497) 329.3604 > (497) FGFR-P496 > (497) pyrido[2,3-d]pyrimidin-7-one deriv. 26 > (497) FGFR-1 Tyrosine Kinase > (497) 4700 > (497) BINDDB > (497) <2007 > (497) P > (497) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 28 csChFnd70/04170815452D 62 65 0 0 0 0 0 0 0 0999 V2000 11.0496 11.5501 -3.0955 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4215 9.7390 -1.1494 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5562 12.5673 -3.1660 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9975 12.0690 -2.1530 C 0 0 0 0 0 0 0 0 0 0 0 0 12.6449 14.0611 -4.2240 C 0 0 0 0 0 0 0 0 0 0 0 0 15.6158 14.4579 -3.1825 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9556 15.2945 -3.1977 O 0 0 0 0 0 0 0 0 0 0 0 0 14.1450 15.0106 -4.2487 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4953 13.0285 -2.1861 N 0 0 3 0 0 0 0 0 0 0 0 0 13.8719 10.6582 -1.1734 N 0 0 0 0 0 0 0 0 0 0 0 0 11.0404 10.1689 -2.0852 N 0 0 0 0 0 0 0 0 0 0 0 0 12.3419 8.2800 -0.1137 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7816 7.3661 0.0486 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8026 5.5771 0.2536 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2630 4.6768 0.4143 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6743 7.3466 0.1731 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2125 8.2489 0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 16.9786 12.4930 -1.1270 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2790 16.5828 -5.3448 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3715 19.4827 -6.0236 C 0 0 0 0 0 0 0 0 0 0 0 0 13.2404 18.0220 -4.9985 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4498 16.6320 -6.7220 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5691 18.1002 -7.7380 C 0 0 0 0 0 0 0 0 0 0 0 0 14.5305 19.5212 -7.3923 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6959 5.5588 0.3703 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1806 4.6713 0.5281 O 0 0 0 0 0 0 0 0 0 0 0 0 4.6156 5.6618 0.4716 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0579 4.4491 0.6683 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0528 3.7012 2.4200 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3517 2.9526 2.8377 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2198 2.6620 4.7957 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4349 2.4046 2.6127 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2680 1.0422 1.1803 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9192 11.8934 -3.8473 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5463 14.4476 -5.0017 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3669 7.8885 0.5012 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0224 4.8902 0.2868 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2791 3.2856 0.5737 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4537 8.0323 0.1395 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1954 9.6407 -0.1413 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7996 11.6181 -1.8741 H 0 0 0 0 0 0 0 0 0 0 0 0 17.7247 13.6329 -0.7505 H 0 0 0 0 0 0 0 0 0 0 0 0 16.5149 11.8297 0.0318 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5678 20.5980 -5.7567 H 0 0 0 0 0 0 0 0 0 0 0 0 12.3349 17.9932 -3.9308 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2617 15.5235 -6.9927 H 0 0 0 0 0 0 0 0 0 0 0 0 16.4756 18.1400 -8.8046 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6285 20.6674 -8.1910 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6157 6.6033 1.5257 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5316 6.3399 -0.7657 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8645 5.1783 0.4638 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1454 3.4112 -0.2871 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3322 3.8393 2.4233 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2031 1.7173 2.1670 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.0138 5.0948 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2989 1.8570 5.2262 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2666 3.9079 5.4612 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6937 3.0399 2.5144 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3206 1.7780 3.8744 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1945 0.0000 1.4109 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9565 0.5153 1.1817 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5341 1.6405 -0.0724 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 34 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 35 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 36 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 37 1 0 0 0 0 15 25 2 0 0 0 0 15 38 1 0 0 0 0 16 25 1 0 0 0 0 16 17 2 0 0 0 0 16 39 1 0 0 0 0 17 40 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 44 1 0 0 0 0 21 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 23 24 2 0 0 0 0 23 47 1 0 0 0 0 24 48 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 30 1 0 0 0 0 29 32 1 0 0 0 0 30 31 1 0 0 0 0 30 53 1 0 0 0 0 30 54 1 0 0 0 0 31 55 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 33 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 33 60 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 M END > (499) 498 > (499) C26H29N5O2 > (499) 443.5474 > (499) FGFR-P498 > (499) pyrido[2,3-d]pyrimidin-7-one deriv. 28 > (499) FGFR-1 Tyrosine Kinase > (499) 350 > (499) BINDDB > (499) <2007 > (499) P > (499) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 29 csChFnd70/04170815452D 59 62 0 0 0 0 0 0 0 0999 V2000 10.9445 11.4450 -3.0631 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3033 9.6499 -1.1365 C 0 0 0 0 0 0 0 0 0 0 0 0 12.4361 12.4523 -3.1324 C 0 0 0 0 0 0 0 0 0 0 0 0 13.8634 11.9587 -2.1297 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5238 13.9336 -4.1803 C 0 0 0 0 0 0 0 0 0 0 0 0 15.4658 14.3261 -3.1485 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7922 15.1559 -3.1626 O 0 0 0 0 0 0 0 0 0 0 0 0 14.0083 14.8737 -4.2044 C 0 0 0 0 0 0 0 0 0 0 0 0 15.3471 12.9099 -2.1622 N 0 0 3 0 0 0 0 0 0 0 0 0 13.7395 10.5607 -1.1599 N 0 0 0 0 0 0 0 0 0 0 0 0 10.9355 10.0760 -2.0629 N 0 0 0 0 0 0 0 0 0 0 0 0 12.2247 8.2036 -0.1108 N 0 0 3 0 0 0 0 0 0 0 0 0 10.6792 7.2979 0.0496 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7003 5.5261 0.2521 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1756 4.6340 0.4109 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6015 7.2780 0.1726 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1250 8.1720 0.0137 C 0 0 0 0 0 0 0 0 0 0 0 0 16.8163 12.3797 -1.1132 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6233 5.5072 0.3676 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1224 4.6276 0.5229 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5722 5.6086 0.4671 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0294 4.4069 0.6607 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0242 3.6648 2.3953 N 0 0 0 0 0 0 0 0 0 0 0 0 1.3392 2.9228 2.8081 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2082 2.6337 4.7474 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3934 2.3808 2.5857 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2286 1.0322 1.1659 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1407 16.4324 -5.2899 C 0 0 0 0 0 0 0 0 0 0 0 0 14.3343 18.0191 -4.6303 C 0 0 0 0 0 0 0 0 0 0 0 0 14.0827 16.3758 -7.0786 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2205 17.8936 -7.8517 C 0 0 0 0 0 0 0 0 0 0 0 0 14.4422 19.5270 -6.3084 S 0 0 0 0 0 0 0 0 0 0 0 0 9.8247 11.7853 -3.8078 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4355 14.3166 -4.9503 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2401 7.8157 0.4979 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9088 4.8459 0.2850 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1918 3.2559 0.5683 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3924 7.9570 0.1396 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1078 9.5507 -0.1379 H 0 0 0 0 0 0 0 0 0 0 0 0 17.6298 11.5136 -1.8532 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5549 13.5089 -0.7401 H 0 0 0 0 0 0 0 0 0 0 0 0 16.3573 11.7224 0.0345 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5720 6.5405 1.5118 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4892 6.2808 -0.7580 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8473 5.1290 0.4584 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1165 3.3794 -0.2862 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3293 3.8012 2.3980 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1924 1.6997 2.1431 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.9913 5.0429 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2771 1.8364 5.1737 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2542 3.8675 5.4073 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6402 3.0103 2.4891 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2800 1.7595 3.8351 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4925 1.6256 -0.0742 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1465 0.0000 1.3940 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9296 0.5101 1.1666 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4109 18.3198 -3.2782 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9374 15.1899 -7.7832 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1992 18.0928 -9.2243 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 33 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 34 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 28 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 35 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 36 1 0 0 0 0 15 19 2 0 0 0 0 15 37 1 0 0 0 0 16 19 1 0 0 0 0 16 17 2 0 0 0 0 16 38 1 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 18 42 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 21 43 1 0 0 0 0 21 44 1 0 0 0 0 22 23 1 0 0 0 0 22 45 1 0 0 0 0 22 46 1 0 0 0 0 23 24 1 0 0 0 0 23 26 1 0 0 0 0 24 25 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 27 54 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 29 2 0 0 0 0 28 30 1 0 0 0 0 29 32 1 0 0 0 0 29 57 1 0 0 0 0 30 31 2 0 0 0 0 30 58 1 0 0 0 0 31 32 1 0 0 0 0 31 59 1 0 0 0 0 M END > (500) 499 > (500) C24H27N5O2S > (500) 449.5696 > (500) FGFR-P499 > (500) pyrido[2,3-d]pyrimidin-7-one deriv. 29 > (500) FGFR-1 Tyrosine Kinase > (500) 2900 > (500) BINDDB > (500) <2007 > (500) P > (500) TRAIN $$$$ 1,6-naphthyridin 36 csChFnd70/04170815452D 66 68 0 0 0 0 0 0 0 0999 V2000 1.1158 15.2141 -2.4536 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2011 12.3956 -1.8570 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9203 12.9968 -1.6412 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8145 15.9514 -2.2611 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2639 14.8179 -1.8429 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1213 17.7817 -2.4713 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2134 17.1917 -1.8431 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8404 18.3994 -2.2584 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8768 13.4984 -2.2487 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8975 15.4830 -1.6519 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2368 20.3167 -2.4661 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5209 23.2335 -1.2041 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1494 21.4485 -1.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7060 20.9952 -4.1249 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0744 22.7828 -4.3094 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9793 23.8994 -2.8538 C 0 0 0 0 0 0 0 0 0 0 0 0 1.8453 10.5946 -1.6611 N 0 0 3 0 0 0 0 0 0 0 0 0 3.2858 9.3598 -1.2300 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5421 7.4739 -1.0901 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8276 19.5958 -5.9531 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5744 20.6156 1.0693 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.0464 6.1844 -0.6400 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3027 4.2984 -0.5000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7471 3.0603 -0.0679 N 0 0 0 0 0 0 0 0 0 0 0 0 4.0445 1.2976 0.3859 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2640 1.3419 2.2615 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0312 2.9453 -1.5320 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7393 2.0683 -0.8676 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9340 17.8202 -1.6315 N 0 0 3 0 0 0 0 0 0 0 0 0 9.2594 16.6842 -1.2349 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9482 15.1095 -1.0623 O 0 0 0 0 0 0 0 0 0 0 0 0 10.9295 17.2943 -1.0296 N 0 0 3 0 0 0 0 0 0 0 0 0 12.3701 16.0595 -0.5984 C 0 0 0 0 0 0 0 0 0 0 0 0 14.1169 17.0854 -0.4397 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.0596 -2.7655 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9797 12.0838 -1.3230 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0482 18.6787 -2.7896 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4538 24.1113 -0.0717 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4379 23.3098 -5.5930 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2684 25.2959 -3.0051 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6433 10.1555 -1.8098 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2895 9.4065 -2.2721 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8834 9.7376 0.0331 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5383 7.4271 -0.0481 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9443 7.0960 -2.3532 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0502 6.2311 -1.6820 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6441 6.5622 0.6231 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2989 4.2517 0.5420 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7050 3.9206 -1.7631 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0102 0.9325 -0.5587 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1138 0.3232 0.3311 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0878 2.1855 2.2749 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9000 0.0000 2.6644 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2482 1.8716 3.1814 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4688 2.1543 -2.6061 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3294 4.2760 -2.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3379 2.8940 0.1598 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4308 0.7643 -0.3198 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6667 1.9215 -1.9696 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1825 19.0768 -1.7693 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1779 18.5509 -1.1672 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0814 15.4011 0.6579 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4862 15.0685 -1.6472 H 0 0 0 0 0 0 0 0 0 0 0 0 14.4056 17.7441 -1.6960 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0007 18.0767 0.6090 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1886 16.1668 -0.1190 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 35 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 36 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 37 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 38 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 39 1 0 0 0 0 16 40 1 0 0 0 0 17 18 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 22 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 22 23 1 0 0 0 0 22 46 1 0 0 0 0 22 47 1 0 0 0 0 23 24 1 0 0 0 0 23 48 1 0 0 0 0 23 49 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 50 1 0 0 0 0 25 51 1 0 0 0 0 26 52 1 0 0 0 0 26 53 1 0 0 0 0 26 54 1 0 0 0 0 27 28 1 0 0 0 0 27 55 1 0 0 0 0 27 56 1 0 0 0 0 28 57 1 0 0 0 0 28 58 1 0 0 0 0 28 59 1 0 0 0 0 29 30 1 0 0 0 0 29 60 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 32 61 1 0 0 0 0 33 34 1 0 0 0 0 33 62 1 0 0 0 0 33 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 34 66 1 0 0 0 0 M END > (51) 49 > (51) C25H32Cl2N6O > (51) 503.4734 > (51) FGFR-P49 > (51) 1,6-naphthyridine 36 > (51) FGFR-1 Tyrosine Kinase > (51) 29 > (51) BINDDB > (51) <2007 > (51) P > (51) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 47 csChFnd70/04170815452D 44 47 0 0 0 0 0 0 0 0999 V2000 3.9589 7.9644 -0.6175 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3107 5.7175 -0.2249 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3539 8.7728 -0.6190 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7322 7.9430 -0.4088 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3931 10.3836 -0.8261 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1917 10.2247 -0.5982 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4337 10.8707 -0.5906 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7838 11.1199 -0.8192 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1204 8.6906 -0.4035 N 0 0 3 0 0 0 0 0 0 0 0 0 6.6553 6.4304 -0.2178 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9914 6.4609 -0.4195 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2788 4.1430 -0.0225 N 0 0 3 0 0 0 0 0 0 0 0 0 3.8720 3.3781 0.1081 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7074 1.9008 -0.4741 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3160 1.1486 -0.3432 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0872 1.8646 0.3660 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2471 3.3354 0.9469 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6373 4.0914 0.8261 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8635 12.8072 -1.0339 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3031 15.3590 -0.1454 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2254 13.7886 0.0609 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5827 13.4206 -2.3281 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6533 14.9928 -2.5218 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0123 15.9604 -1.4351 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5395 7.8119 -0.1833 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1552 7.2916 -1.7459 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8808 8.5603 -0.7699 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3422 11.0237 -0.9878 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2326 3.5682 0.0290 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6665 1.3413 -1.0288 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1873 0.0000 -0.7957 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 1.2742 0.4662 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2849 3.8915 1.4998 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7630 5.2377 1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8094 16.1200 0.7016 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6711 13.3204 1.0679 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0837 12.6663 -3.1771 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2102 15.4692 -3.5235 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0700 17.1904 -1.5918 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3933 8.5325 0.3831 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3028 6.8079 0.5275 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3918 8.2955 -2.4569 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2110 6.6376 -1.5822 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3013 6.5709 -2.3123 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 28 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 19 1 0 0 0 0 9 25 1 0 0 0 0 12 13 1 0 0 0 0 12 29 1 0 0 0 0 13 14 2 0 0 0 0 13 18 1 0 0 0 0 14 15 1 0 0 0 0 14 30 1 0 0 0 0 15 16 2 0 0 0 0 15 31 1 0 0 0 0 16 17 1 0 0 0 0 16 32 1 0 0 0 0 17 18 2 0 0 0 0 17 33 1 0 0 0 0 18 34 1 0 0 0 0 19 21 1 0 0 0 0 19 22 2 0 0 0 0 20 21 2 0 0 0 0 20 24 1 0 0 0 0 20 35 1 0 0 0 0 21 36 1 0 0 0 0 22 23 1 0 0 0 0 22 37 1 0 0 0 0 23 24 2 0 0 0 0 23 38 1 0 0 0 0 24 39 1 0 0 0 0 25 26 1 0 0 0 0 25 40 1 0 0 0 0 25 41 1 0 0 0 0 26 42 1 0 0 0 0 26 43 1 0 0 0 0 26 44 1 0 0 0 0 M END > (505) 504 > (505) C21H18N4O > (505) 342.3994 > (505) FGFR-P504 > (505) pyrido[2,3-d]pyrimidin-7-one deriv. 47 > (505) FGFR-1 Tyrosine Kinase > (505) 1500 > (505) BINDDB > (505) <2007 > (505) P > (505) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 5 csChFnd70/04170815452D 34 36 0 0 0 0 0 0 0 0999 V2000 1.2020 4.9841 0.0119 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6967 2.4255 -0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7722 5.8679 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3090 4.9059 -0.0181 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8305 7.6827 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9647 7.4489 -0.0191 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3949 8.4855 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2251 3.2888 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2095 3.2026 -0.0263 N 0 0 0 0 0 0 0 0 0 0 0 0 7.3620 8.1528 -0.0283 O 0 0 0 0 0 0 0 0 0 0 0 0 5.8710 5.7215 -0.0281 N 0 0 3 0 0 0 0 0 0 0 0 0 4.4992 10.3855 0.0107 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6598 13.0473 1.5644 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5628 11.2759 1.5648 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5417 11.2921 -1.5349 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6388 13.0633 -1.5173 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6941 13.9387 0.0279 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5191 10.1597 3.4946 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4734 10.1961 -3.4756 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6470 0.6529 -0.0252 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4533 4.7032 -0.0480 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9871 4.3587 -1.9077 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6761 0.0329 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6584 8.4247 0.0262 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7086 13.7381 2.7664 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6724 13.7666 -2.7126 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7700 15.3238 0.0346 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5510 0.0604 -0.0179 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7081 0.0000 -0.0388 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4703 5.4085 0.6064 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2331 3.4860 0.6074 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1644 3.6011 -1.9225 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9700 3.6535 -2.5622 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2073 5.5760 -2.5632 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 23 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 24 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 25 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 26 1 0 0 0 0 17 27 1 0 0 0 0 20 28 1 0 0 0 0 20 29 1 0 0 0 0 21 22 1 0 0 0 0 21 30 1 0 0 0 0 21 31 1 0 0 0 0 22 32 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 M END > (507) 506 > (507) C15H12Cl2N4O > (507) 335.192 > (507) FGFR-P506 > (507) pyrido[2,3-d]pyrimidin-7-one deriv. 5 > (507) FGFR-1 Tyrosine Kinase > (507) 540 > (507) BINDDB > (507) <2007 > (507) P > (507) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 53 csChFnd70/04170815452D 43 46 0 0 0 0 0 0 0 0999 V2000 3.6801 7.9396 -0.5665 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0319 5.6870 -0.2076 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0760 8.7467 -0.5677 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4548 7.9129 -0.3754 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1159 10.3598 -0.7571 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9158 10.1952 -0.5483 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1587 10.8397 -0.5415 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5075 11.0945 -0.7504 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8439 8.6592 -0.3703 N 0 0 3 0 0 0 0 0 0 0 0 0 6.3773 6.3983 -0.2008 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7122 6.4338 -0.3856 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9994 4.1095 -0.0225 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5967 3.3471 0.1077 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4105 1.8638 -0.4700 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0040 1.1487 -0.3175 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9769 3.2514 0.9308 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3450 4.0452 0.8249 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2634 7.7761 -0.1693 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8686 7.2732 -1.7419 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5878 12.7843 -0.9467 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0359 15.3265 -0.0262 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9576 13.7539 0.1630 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2997 13.4112 -2.2386 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3708 14.9857 -2.4150 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7378 15.9417 -1.3134 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8446 1.8508 0.3637 N 0 0 0 0 0 0 0 0 0 0 0 0 2.6018 8.5385 -0.7055 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0645 11.0028 -0.9050 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9529 3.5330 0.0168 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3543 1.2831 -1.0293 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8493 0.0000 -0.7615 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.7851 1.4800 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4456 5.1911 1.2915 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1218 8.4894 0.3999 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0301 6.7643 0.5315 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9248 6.6163 -1.5924 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0102 6.5600 -2.3111 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1019 8.2852 -2.4427 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5482 16.0788 0.8324 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4089 13.2750 1.1681 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7947 12.6660 -3.0990 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9223 15.4726 -3.4148 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7967 17.1733 -1.4564 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 28 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 20 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 29 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 30 1 0 0 0 0 15 26 2 0 0 0 0 15 31 1 0 0 0 0 16 26 1 0 0 0 0 16 17 2 0 0 0 0 16 32 1 0 0 0 0 17 33 1 0 0 0 0 18 19 1 0 0 0 0 18 34 1 0 0 0 0 18 35 1 0 0 0 0 19 36 1 0 0 0 0 19 37 1 0 0 0 0 19 38 1 0 0 0 0 20 22 1 0 0 0 0 20 23 2 0 0 0 0 21 22 2 0 0 0 0 21 25 1 0 0 0 0 21 39 1 0 0 0 0 22 40 1 0 0 0 0 23 24 1 0 0 0 0 23 41 1 0 0 0 0 24 25 2 0 0 0 0 24 42 1 0 0 0 0 25 43 1 0 0 0 0 M END > (508) 507 > (508) C20H17N5O > (508) 343.3872 > (508) FGFR-P507 > (508) pyrido[2,3-d]pyrimidin-7-one deriv. 53 > (508) FGFR-1 Tyrosine Kinase > (508) 1100 > (508) BINDDB > (508) <2007 > (508) P > (508) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 54 csChFnd70/04170815452D 65 68 0 0 0 0 0 0 0 0999 V2000 11.6998 11.3547 2.1151 C 0 0 0 0 0 0 0 0 0 0 0 0 12.7976 8.5780 1.9341 C 0 0 0 0 0 0 0 0 0 0 0 0 13.3877 11.9718 2.3981 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7661 10.7677 2.4330 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7170 13.7578 2.6441 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7868 13.0129 2.9436 C 0 0 0 0 0 0 0 0 0 0 0 0 18.2763 13.4803 3.1829 O 0 0 0 0 0 0 0 0 0 0 0 0 15.3872 14.2956 2.9150 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4355 11.3188 2.7055 N 0 0 3 0 0 0 0 0 0 0 0 0 14.4127 9.0988 2.1969 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4690 9.6737 1.8930 N 0 0 0 0 0 0 0 0 0 0 0 0 12.4829 6.8313 1.6939 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7765 6.2272 1.5542 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4027 4.8216 0.4924 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7196 4.2262 0.3556 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7759 6.4314 2.3446 C 0 0 0 0 0 0 0 0 0 0 0 0 9.4583 7.0285 2.4826 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8504 10.0518 2.7377 C 0 0 0 0 0 0 0 0 0 0 0 0 18.5741 9.8219 0.9050 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7749 16.1590 3.1766 C 0 0 0 0 0 0 0 0 0 0 0 0 15.5065 18.7577 4.8698 C 0 0 0 0 0 0 0 0 0 0 0 0 15.1406 17.0225 4.6331 C 0 0 0 0 0 0 0 0 0 0 0 0 16.7819 17.0547 1.9709 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1392 18.7896 2.2218 C 0 0 0 0 0 0 0 0 0 0 0 0 16.5004 19.6409 3.6659 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4023 5.0320 1.2781 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7453 4.4453 1.1421 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4539 5.3364 2.1282 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6843 4.4976 1.8113 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6954 2.7171 2.4877 N 0 0 0 0 0 0 0 0 0 0 0 0 2.8676 2.7085 4.3847 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3426 0.8824 4.9973 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1369 1.7689 1.9396 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3045 1.2708 0.0267 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6120 12.2360 2.0855 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6673 14.6843 2.6180 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4439 6.0231 1.6222 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4279 4.1947 -0.2264 H 0 0 0 0 0 0 0 0 0 0 0 0 8.4286 3.1333 -0.4699 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7497 7.0579 3.0625 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7489 8.1179 3.3132 H 0 0 0 0 0 0 0 0 0 0 0 0 18.8755 10.5122 3.5949 H 0 0 0 0 0 0 0 0 0 0 0 0 17.3622 8.8125 3.2103 H 0 0 0 0 0 0 0 0 0 0 0 0 19.0622 11.0613 0.4324 H 0 0 0 0 0 0 0 0 0 0 0 0 19.6269 8.8792 0.9290 H 0 0 0 0 0 0 0 0 0 0 0 0 17.5489 9.3616 0.0480 H 0 0 0 0 0 0 0 0 0 0 0 0 15.0160 19.4280 5.9974 H 0 0 0 0 0 0 0 0 0 0 0 0 14.3641 16.3346 5.5738 H 0 0 0 0 0 0 0 0 0 0 0 0 17.2814 16.3913 0.8433 H 0 0 0 0 0 0 0 0 0 0 0 0 17.9192 19.4845 1.2890 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7836 20.9990 3.8566 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7733 5.2576 3.5026 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4105 6.6921 1.7314 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6833 5.2460 2.4710 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4164 4.4727 0.4237 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8828 3.6135 4.7695 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6421 3.0982 4.9707 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2738 0.0000 4.7209 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5025 0.4446 4.3189 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5896 0.9018 6.3889 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9981 0.5991 2.7205 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 2.5900 2.1148 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3006 2.4404 -0.7667 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5153 0.5698 -0.1734 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2169 0.4473 -0.3428 H 0 0 0 0 0 0 0 0 0 0 0 0 1 11 1 0 0 0 0 1 3 2 0 0 0 0 1 35 1 0 0 0 0 2 11 2 0 0 0 0 2 10 1 0 0 0 0 2 12 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 10 2 0 0 0 0 4 9 1 0 0 0 0 5 8 2 0 0 0 0 5 36 1 0 0 0 0 6 9 1 0 0 0 0 6 8 1 0 0 0 0 6 7 2 0 0 0 0 8 20 1 0 0 0 0 9 18 1 0 0 0 0 12 13 1 0 0 0 0 12 37 1 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 14 15 1 0 0 0 0 14 38 1 0 0 0 0 15 26 2 0 0 0 0 15 39 1 0 0 0 0 16 26 1 0 0 0 0 16 17 2 0 0 0 0 16 40 1 0 0 0 0 17 41 1 0 0 0 0 18 19 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 19 44 1 0 0 0 0 19 45 1 0 0 0 0 19 46 1 0 0 0 0 20 22 1 0 0 0 0 20 23 2 0 0 0 0 21 22 2 0 0 0 0 21 25 1 0 0 0 0 21 47 1 0 0 0 0 22 48 1 0 0 0 0 23 24 1 0 0 0 0 23 49 1 0 0 0 0 24 25 2 0 0 0 0 24 50 1 0 0 0 0 25 51 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 30 31 1 0 0 0 0 30 33 1 0 0 0 0 31 32 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 32 58 1 0 0 0 0 32 59 1 0 0 0 0 32 60 1 0 0 0 0 33 34 1 0 0 0 0 33 61 1 0 0 0 0 33 62 1 0 0 0 0 34 63 1 0 0 0 0 34 64 1 0 0 0 0 34 65 1 0 0 0 0 M END > (509) 508 > (509) C27H31N5O2 > (509) 457.5742 > (509) FGFR-P508 > (509) pyrido[2,3-d]pyrimidin-7-one deriv. 54 > (509) FGFR-1 Tyrosine Kinase > (509) 88 > (509) BINDDB > (509) <2007 > (509) P > (509) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 6 csChFnd70/04170815452D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7218 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9226 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9516 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8569 7.7543 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0202 7.5183 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4359 8.5645 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2487 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2287 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9257 5.7748 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4823 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7032 13.1688 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6053 11.3809 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3973 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6821 13.1850 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7378 14.0685 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2543 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5151 10.2910 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5227 4.7470 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0615 4.3993 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7293 3.3259 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7289 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5032 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7525 13.8660 2.7922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7159 13.8948 -2.7379 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4664 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7426 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5492 5.4589 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3005 3.5184 0.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0349 3.6875 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2837 5.6279 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1132 3.0782 -3.2836 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7559 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5071 2.0973 -1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 24 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 25 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 26 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 27 1 0 0 0 0 17 28 1 0 0 0 0 20 29 1 0 0 0 0 20 30 1 0 0 0 0 21 22 1 0 0 0 0 21 31 1 0 0 0 0 21 32 1 0 0 0 0 22 23 1 0 0 0 0 22 33 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 M END > (510) 509 > (510) C16H14Cl2N4O > (510) 349.2188 > (510) FGFR-P509 > (510) pyrido[2,3-d]pyrimidin-7-one deriv. 6 > (510) FGFR-1 Tyrosine Kinase > (510) 510 > (510) BINDDB > (510) <2007 > (510) P > (510) TRAIN $$$$ 1,6-naphthyridin 37 csChFnd70/04170815452D 72 74 0 0 0 0 0 0 0 0999 V2000 1.1348 15.3372 0.5765 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3511 12.5847 0.3606 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9975 13.2324 0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7536 16.1189 0.2638 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2324 15.0433 -0.0117 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9516 17.9378 0.2150 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0051 17.4506 -0.3643 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5968 18.6018 -0.1027 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9963 13.6339 0.6127 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7913 15.7515 -0.3131 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8774 20.5097 -0.1683 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5642 23.1983 1.2731 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3038 21.4210 1.3430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7234 21.4000 -1.7430 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9871 23.1776 -1.7957 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4035 24.0746 -0.2914 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1030 10.7932 0.4175 N 0 0 3 0 0 0 0 0 0 0 0 0 3.5787 9.6173 0.1432 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9562 7.7301 0.2717 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2022 20.2762 -3.6327 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.5060 20.3235 3.3076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.4973 6.5019 -0.0147 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8749 4.6148 0.1137 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3545 3.4354 -0.1613 N 0 0 0 0 0 0 0 0 0 0 0 0 6.6281 3.5918 1.2561 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3439 2.7458 0.7032 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7633 1.6276 -0.3545 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9832 1.3747 -2.1692 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6512 18.1253 -0.6822 N 0 0 3 0 0 0 0 0 0 0 0 0 9.0088 17.0437 -0.9345 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7921 15.4770 -0.8838 O 0 0 0 0 0 0 0 0 0 0 0 0 10.6066 17.6986 -1.2433 N 0 0 3 0 0 0 0 0 0 0 0 0 11.7236 15.3648 -3.0974 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7318 17.5912 -1.8384 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0823 16.5226 -1.5175 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3327 15.3841 0.0970 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.1378 0.7942 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0833 12.3625 -0.1579 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8534 18.7912 0.4188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8944 23.9055 2.4420 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8683 23.8686 -3.0141 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6084 25.4645 -0.3393 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9528 10.3220 0.6388 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1329 9.8459 -1.1427 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5658 9.8581 1.1333 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4020 7.5014 1.5576 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9691 7.4892 -0.7183 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0515 6.7305 -1.3005 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4844 6.7428 0.9753 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3208 4.3860 1.3996 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8879 4.3738 -0.8763 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8486 4.9634 1.5445 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1303 2.9394 2.4133 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1115 1.3914 0.3510 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8753 3.4404 -0.4139 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2674 2.8029 1.7787 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8644 0.7491 -0.1866 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7786 1.3445 0.6268 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6997 0.0000 -2.3749 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7848 2.1261 -2.2778 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9096 1.8180 -3.1482 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8240 19.3753 -0.7227 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7795 18.9486 -1.2837 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5453 16.1759 -4.2474 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8215 14.4899 -3.3015 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5486 14.6035 -2.8688 H 0 0 0 0 0 0 0 0 0 0 0 0 13.9872 18.4162 -0.7129 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8297 16.7163 -2.0425 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5533 18.4024 -2.9886 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1577 14.6227 0.3255 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4307 14.5091 -0.1071 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5882 16.2089 1.2224 H 0 0 0 0 0 0 0 0 0 0 0 0 1 9 1 0 0 0 0 1 4 2 0 0 0 0 1 37 1 0 0 0 0 2 9 2 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 3 5 2 0 0 0 0 3 38 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 10 1 0 0 0 0 6 8 2 0 0 0 0 6 39 1 0 0 0 0 7 10 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 11 1 0 0 0 0 11 13 1 0 0 0 0 11 14 2 0 0 0 0 12 13 2 0 0 0 0 12 16 1 0 0 0 0 12 40 1 0 0 0 0 13 21 1 0 0 0 0 14 15 1 0 0 0 0 14 20 1 0 0 0 0 15 16 2 0 0 0 0 15 41 1 0 0 0 0 16 42 1 0 0 0 0 17 18 1 0 0 0 0 17 43 1 0 0 0 0 18 19 1 0 0 0 0 18 44 1 0 0 0 0 18 45 1 0 0 0 0 19 22 1 0 0 0 0 19 46 1 0 0 0 0 19 47 1 0 0 0 0 22 23 1 0 0 0 0 22 48 1 0 0 0 0 22 49 1 0 0 0 0 23 24 1 0 0 0 0 23 50 1 0 0 0 0 23 51 1 0 0 0 0 24 27 1 0 0 0 0 24 25 1 0 0 0 0 25 26 1 0 0 0 0 25 52 1 0 0 0 0 25 53 1 0 0 0 0 26 54 1 0 0 0 0 26 55 1 0 0 0 0 26 56 1 0 0 0 0 27 28 1 0 0 0 0 27 57 1 0 0 0 0 27 58 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 29 30 1 0 0 0 0 29 62 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 35 1 0 0 0 0 32 63 1 0 0 0 0 33 35 1 0 0 0 0 33 64 1 0 0 0 0 33 65 1 0 0 0 0 33 66 1 0 0 0 0 34 35 1 0 0 0 0 34 67 1 0 0 0 0 34 68 1 0 0 0 0 34 69 1 0 0 0 0 35 36 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 36 72 1 0 0 0 0 M END > (52) 50 > (52) C27H36Cl2N6O > (52) 531.527 > (52) FGFR-P50 > (52) 1,6-naphthyridine 37 > (52) FGFR-1 Tyrosine Kinase > (52) 25 > (52) BINDDB > (52) <2007 > (52) P > (52) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 7 csChFnd70/04170815452D 40 42 0 0 0 0 0 0 0 0999 V2000 1.2133 5.0305 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7218 2.4481 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7980 5.9226 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3491 4.9516 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8569 7.7543 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0202 7.5183 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4359 8.5645 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2365 3.3194 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2487 3.2324 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4305 8.2287 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9257 5.7748 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5411 10.4823 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7032 13.1688 1.5790 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6053 11.3809 1.5794 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5840 11.3973 -1.5492 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6821 13.1850 -1.5314 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7378 14.0685 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5612 10.2543 3.5271 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5151 10.2910 -3.5079 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6716 0.6590 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5227 4.7470 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0615 4.3993 -1.9255 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7293 3.3259 -1.9465 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2681 2.9781 -3.8235 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7289 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6739 8.5032 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7525 13.8660 2.7922 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7159 13.8948 -2.7379 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8144 15.4664 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5655 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7426 0.0000 -0.0392 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5492 5.4589 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3005 3.5184 0.6131 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0349 3.6875 -2.5860 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2837 5.6279 -2.5871 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7559 4.0376 -1.2860 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5071 2.0973 -1.2849 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2416 2.2664 -4.4841 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4903 4.2068 -4.4851 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4564 2.2135 -3.8385 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 34 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (511) 510 > (511) C17H16Cl2N4O > (511) 363.2456 > (511) FGFR-P510 > (511) pyrido[2,3-d]pyrimidin-7-one deriv. 7 > (511) FGFR-1 Tyrosine Kinase > (511) 580 > (511) BINDDB > (511) <2007 > (511) P > (511) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 8 csChFnd70/04170815452D 40 42 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0300 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7215 2.4478 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7977 5.9219 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3487 4.9511 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7535 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0196 7.5176 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 8.5637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3191 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2483 3.2321 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4298 8.2279 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9251 5.7742 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5407 10.4812 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7027 13.1674 1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3798 1.5792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 11.3961 -1.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6816 13.1836 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0670 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5608 10.2533 3.5267 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2900 -3.5076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6713 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5220 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0607 4.3989 -1.9253 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5285 6.1125 -2.8072 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6344 3.1922 -1.9485 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7283 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6737 8.5023 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7520 13.8646 2.7919 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7154 13.8933 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8140 15.4647 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7422 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5484 5.4583 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2998 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9900 3.7899 -2.6175 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9123 5.8648 -4.1442 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4072 6.9722 -2.7906 H 0 0 0 0 0 0 0 0 0 0 0 0 9.5991 6.7215 -2.1149 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3012 1.9712 -1.3203 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0183 2.9444 -3.2856 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7052 3.8012 -1.2564 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 26 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 27 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 28 1 0 0 0 0 17 29 1 0 0 0 0 20 30 1 0 0 0 0 20 31 1 0 0 0 0 21 22 1 0 0 0 0 21 32 1 0 0 0 0 21 33 1 0 0 0 0 22 23 1 0 0 0 0 22 24 1 0 0 0 0 22 34 1 0 0 0 0 23 35 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (512) 511 > (512) C17H16Cl2N4O > (512) 363.2456 > (512) FGFR-P511 > (512) pyrido[2,3-d]pyrimidin-7-one deriv. 8 > (512) FGFR-1 Tyrosine Kinase > (512) 500 > (512) BINDDB > (512) <2007 > (512) P > (512) TRAIN $$$$ pyrido[2,3-d]pyrimidin-7-one deriv. 9 csChFnd70/04170815452D 37 39 0 0 0 0 0 0 0 0999 V2000 1.2132 5.0300 0.0120 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7215 2.4478 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7977 5.9219 0.0017 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3487 4.9511 -0.0183 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8566 7.7535 0.0115 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0196 7.5176 -0.0193 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4354 8.5637 0.0014 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2364 3.3191 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 4.2483 3.2321 -0.0266 N 0 0 0 0 0 0 0 0 0 0 0 0 7.4298 8.2279 -0.0285 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9251 5.7742 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 4.5407 10.4812 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7027 13.1674 1.5788 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6049 11.3798 1.5792 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5836 11.3961 -1.5490 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6816 13.1836 -1.5313 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7374 14.0670 0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5608 10.2533 3.5267 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5147 10.2900 -3.5076 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6713 0.6589 -0.0254 N 0 0 0 0 0 0 0 0 0 0 0 0 7.5220 4.7466 -0.0485 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0525 4.4041 -1.8970 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1858 4.9611 -3.0767 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4881 3.4801 -2.2332 O 0 0 0 0 0 0 0 0 0 0 0 0 9.9203 3.2009 -4.0437 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.7283 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6737 8.5023 0.0264 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7520 13.8646 2.7919 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7154 13.8933 -2.7376 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8140 15.4647 0.0349 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5653 0.0609 -0.0180 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7422 0.0000 -0.0391 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5484 5.4583 0.6120 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2998 3.5181 0.6130 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1060 2.4377 -4.1325 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8652 2.5076 -4.6782 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1140 4.4479 -4.6793 H 0 0 0 0 0 0 0 0 0 0 0 0 1 8 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 8 2 0 0 0 0 2 9 1 0 0 0 0 2 20 1 0 0 0 0 3 5 1 0 0 0 0 3 4 1 0 0 0 0 4 9 2 0 0 0 0 4 11 1 0 0 0 0 5 7 2 0 0 0 0 5 27 1 0 0 0 0 6 11 1 0 0 0 0 6 7 1 0 0 0 0 6 10 2 0 0 0 0 7 12 1 0 0 0 0 11 21 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 28 1 0 0 0 0 14 18 1 0 0 0 0 15 16 1 0 0 0 0 15 19 1 0 0 0 0 16 17 2 0 0 0 0 16 29 1 0 0 0 0 17 30 1 0 0 0 0 20 31 1 0 0 0 0 20 32 1 0 0 0 0 21 22 1 0 0 0 0 21 33 1 0 0 0 0 21 34 1 0 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 25 35 1 0 0 0 0 25 36 1 0 0 0 0 25 37 1 0 0 0 0 M END > (513) 512 > (513) C16H12Cl2N4O3 > (513) 379.2018 > (513) FGFR-P512 > (513) pyrido[2,3-d]pyrimidin-7-one deriv. 9 > (513) FGFR-1 Tyrosine Kinase > (513) 1700 > (513) BINDDB > (513) <2007 > (513) P > (513) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 10 csChFnd70/04170815452D 40 42 0 0 0 0 0 0 0 0999 V2000 2.4415 6.9418 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2238 6.8576 -0.0158 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8390 7.7098 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9029 4.5448 -0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4635 5.3226 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1028 4.4541 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4914 2.1742 -0.0153 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8917 2.9284 -0.0242 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1657 2.9429 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2185 5.3418 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4663 0.5737 -0.0243 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8811 9.4165 0.0102 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9526 11.8060 1.4029 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9200 11.8201 -1.3595 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9586 12.6058 0.0256 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8813 10.2300 -1.3750 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9140 10.2158 1.4032 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8335 9.2460 -3.1144 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.9058 9.2142 3.1334 Cl 0 0 0 0 0 0 0 0 0 0 0 0 6.6208 7.6351 -0.0254 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9524 6.8381 -0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9303 5.4383 -0.0512 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3086 7.5929 -0.0530 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7560 6.7264 -0.0725 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1130 7.8501 -0.0799 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3669 7.5676 0.0299 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0288 0.0237 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9571 2.2870 -0.0389 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4902 0.0304 -0.0182 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4247 0.0000 -0.0365 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9784 12.4262 2.4807 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9201 12.4512 -2.4312 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9884 13.8491 0.0316 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6384 8.7520 -0.0193 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3263 8.7098 -0.0467 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8214 5.9981 0.9475 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8007 6.0097 -1.1020 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0683 8.5669 0.9496 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1899 7.2055 -0.0945 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0476 8.5787 -1.1000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 26 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 27 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 28 1 0 0 0 0 11 29 1 0 0 0 0 11 30 1 0 0 0 0 12 17 1 0 0 0 0 12 16 2 0 0 0 0 13 17 2 0 0 0 0 13 15 1 0 0 0 0 13 31 1 0 0 0 0 14 16 1 0 0 0 0 14 15 2 0 0 0 0 14 32 1 0 0 0 0 15 33 1 0 0 0 0 16 18 1 0 0 0 0 17 19 1 0 0 0 0 20 21 1 0 0 0 0 20 34 1 0 0 0 0 21 22 2 0 0 0 0 21 23 1 0 0 0 0 23 24 1 0 0 0 0 23 35 1 0 0 0 0 24 25 1 0 0 0 0 24 36 1 0 0 0 0 24 37 1 0 0 0 0 25 38 1 0 0 0 0 25 39 1 0 0 0 0 25 40 1 0 0 0 0 M END > (65) 63 > (65) C17H15Cl2N5O > (65) 376.2444 > (65) FGFR-P63 > (65) 1,6-naphthyridine deriv. 10 > (65) FGFR-1 Tyrosine Kinase > (65) 150 > (65) BINDDB > (65) <2007 > (65) P > (65) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 11 csChFnd70/04170815452D 46 48 0 0 0 0 0 0 0 0999 V2000 2.7234 7.7431 0.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8267 7.6492 -0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2821 8.5999 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3534 5.0694 -0.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7480 5.9369 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2301 4.9682 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7791 2.4252 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3408 3.2665 -0.0270 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3003 3.2827 0.0015 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8208 5.9584 -0.0272 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7510 0.6399 -0.0271 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3290 10.5034 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4088 13.1688 1.5649 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3724 13.1845 -1.5164 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4155 14.0609 0.0285 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3293 11.4108 -1.5337 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3658 11.3950 1.5651 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2760 10.3132 -3.4740 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3566 10.2778 3.4950 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.3851 8.5165 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8704 7.6275 -0.0486 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8457 6.0660 -0.0572 O 0 0 0 0 0 0 0 0 0 0 0 0 10.3831 8.4694 -0.0591 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0677 6.3807 -1.6928 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5113 8.7563 -0.0891 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9976 7.5029 -0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1001 6.3623 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5247 8.4412 0.0334 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6093 0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5292 2.5511 -0.0434 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6622 0.0339 -0.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8200 0.0000 -0.0407 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4376 13.8606 2.7671 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3726 13.8885 -2.7119 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4487 15.4476 0.0352 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4048 9.7623 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4027 9.7152 -0.0521 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9946 7.1931 -2.8307 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2689 5.6617 -1.7090 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9891 5.4877 -1.6869 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4614 9.5558 1.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7125 8.0373 -0.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4383 9.5689 -1.2269 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0216 5.4695 1.5221 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3014 5.6434 1.5000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0503 7.1618 2.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 28 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 20 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 29 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 30 1 0 0 0 0 11 31 1 0 0 0 0 11 32 1 0 0 0 0 12 17 1 0 0 0 0 12 16 2 0 0 0 0 13 17 2 0 0 0 0 13 15 1 0 0 0 0 13 33 1 0 0 0 0 14 16 1 0 0 0 0 14 15 2 0 0 0 0 14 34 1 0 0 0 0 15 35 1 0 0 0 0 16 18 1 0 0 0 0 17 19 1 0 0 0 0 20 21 1 0 0 0 0 20 36 1 0 0 0 0 21 22 2 0 0 0 0 21 23 1 0 0 0 0 23 26 1 0 0 0 0 23 37 1 0 0 0 0 24 26 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 25 26 1 0 0 0 0 25 41 1 0 0 0 0 25 42 1 0 0 0 0 25 43 1 0 0 0 0 26 27 1 0 0 0 0 27 44 1 0 0 0 0 27 45 1 0 0 0 0 27 46 1 0 0 0 0 M END > (66) 64 > (66) C19H19Cl2N5O > (66) 404.298 > (66) FGFR-P64 > (66) 1,6-naphthyridine deriv. 11 > (66) FGFR-1 Tyrosine Kinase > (66) 120 > (66) BINDDB > (66) <2007 > (66) P > (66) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7e csChFnd70/04170815452D 55 57 0 0 0 0 0 0 0 0999 V2000 1.2800 13.2280 -0.4346 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0299 10.7757 -0.4084 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5228 11.7391 -0.7357 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7174 14.2978 -0.7659 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3820 13.5327 -0.9202 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5233 16.1205 -0.9473 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9630 17.1171 -1.2718 C 0 0 0 0 0 0 0 0 0 0 0 0 5.6703 16.2825 -1.4245 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9569 17.1633 -1.7120 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4829 11.5360 -0.2706 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8235 14.5445 -1.2460 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5385 13.7253 -1.4009 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7961 19.0282 -1.4682 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7849 21.8909 -0.2088 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9419 20.1104 -0.0168 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5000 19.7544 -3.1064 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3455 21.5369 -3.2804 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4845 22.6019 -1.8354 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3188 19.2206 2.0258 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.3266 18.4203 -4.9219 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.1556 8.9842 -0.2226 N 0 0 3 0 0 0 0 0 0 0 0 0 4.8524 8.1269 -0.3711 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6294 6.1646 -0.1151 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4014 5.2693 -0.2702 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1873 3.3852 -0.0245 N 0 0 0 0 0 0 0 0 0 0 0 0 5.1650 2.6202 -1.4476 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5504 0.8010 -0.9201 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8837 2.5190 0.1433 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6270 2.8608 1.9589 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 13.7951 -0.3074 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7729 11.1055 -0.8445 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2555 16.7167 -0.8317 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7726 13.3708 -2.7546 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5380 14.6356 -0.9707 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5807 12.5599 -0.5929 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8970 22.7299 0.9136 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1163 22.1007 -4.5477 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3628 23.9950 -1.9784 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1201 8.2990 0.0060 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3976 8.3771 -1.6568 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7284 8.6368 0.6215 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0842 5.9143 1.1707 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7533 5.6547 -1.1077 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9468 5.5196 -1.5559 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2775 5.7792 0.7224 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0390 3.4408 -1.7151 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9703 2.5282 -2.6121 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8484 0.2072 -2.0007 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6735 0.0000 -0.5886 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6913 0.8997 0.2046 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7221 1.1222 -0.0463 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7742 3.0293 -0.8361 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9464 4.2371 2.0878 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6645 2.5051 2.9386 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7995 2.0837 2.1439 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 30 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 31 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 32 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 33 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 36 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 37 1 0 0 0 0 18 38 1 0 0 0 0 21 22 1 0 0 0 0 21 39 1 0 0 0 0 22 23 1 0 0 0 0 22 40 1 0 0 0 0 22 41 1 0 0 0 0 23 24 1 0 0 0 0 23 42 1 0 0 0 0 23 43 1 0 0 0 0 24 25 1 0 0 0 0 24 44 1 0 0 0 0 24 45 1 0 0 0 0 25 28 1 0 0 0 0 25 26 1 0 0 0 0 26 27 1 0 0 0 0 26 46 1 0 0 0 0 26 47 1 0 0 0 0 27 48 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 29 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 29 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 M END > (8) 6 > (8) C22H26Cl2N4O > (8) 433.3796 > (8) FGFR-P6 > (8) 1,6-naphthyridin-2(1H)-one deriv. 7e > (8) FGFR-1 Tyrosine Kinase > (8) 150 > (8) BINDDB > (8) <2007 > (8) P > (8) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 17 csChFnd70/04170815452D 59 61 0 0 0 0 0 0 0 0999 V2000 2.8187 10.4096 0.0223 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9220 10.3149 -0.0053 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3776 11.2660 0.0146 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4481 7.7355 -0.0099 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8428 8.6033 0.0100 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3247 7.6342 0.0161 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8736 5.0916 -0.0146 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4347 5.9316 -0.0231 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3954 5.9488 0.0040 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9157 8.6240 -0.0171 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4250 13.1702 0.0265 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5001 15.8138 1.2123 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5145 16.7348 0.0478 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4585 14.0344 1.2051 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4419 14.0992 -1.1458 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4896 15.8783 -1.1317 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5305 16.7853 -2.2744 O 0 0 0 0 0 0 0 0 0 0 0 0 2.6413 18.6156 -2.1877 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5081 16.6576 2.3610 O 0 0 0 0 0 0 0 0 0 0 0 0 6.4891 18.4920 2.2966 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4807 11.1820 -0.0135 N 0 0 3 0 0 0 0 0 0 0 0 0 8.9658 10.2923 -0.0335 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9408 8.7309 -0.0444 O 0 0 0 0 0 0 0 0 0 0 0 0 10.4790 11.1339 -0.0416 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0934 10.1670 -0.0635 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1644 9.0468 -1.6769 C 0 0 0 0 0 0 0 0 0 0 0 0 13.6076 11.4200 -0.0686 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1942 9.0241 1.5324 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8451 3.3011 -0.0265 N 0 0 3 0 0 0 0 0 0 0 0 0 1.3198 0.5273 0.2504 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3394 2.4583 0.1147 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.2541 0.1324 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6200 11.1080 0.0432 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0944 8.2752 0.0310 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6230 5.2157 -0.0397 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5491 18.1217 0.0564 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2256 13.3182 2.1123 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6438 13.4331 -2.0649 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2279 19.0488 -0.9219 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9655 19.0142 -2.4079 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8152 19.1803 -3.1671 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9186 18.9191 1.0342 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1876 18.9537 2.5277 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3468 19.0025 3.2788 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5008 12.4277 -0.0049 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4990 12.3797 -0.0330 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0926 9.8610 -2.8138 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3657 8.3274 -1.6931 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0858 8.1541 -1.6732 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5570 12.2180 1.0808 H 0 0 0 0 0 0 0 0 0 0 0 0 14.8086 10.7006 -0.0848 H 0 0 0 0 0 0 0 0 0 0 0 0 13.5358 12.2342 -1.2055 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1154 8.1314 1.5362 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3954 8.3046 1.5162 H 0 0 0 0 0 0 0 0 0 0 0 0 12.1435 9.8221 2.6819 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9090 2.6617 -0.1363 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3870 0.1534 1.5981 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1376 0.0317 -0.3130 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4206 0.0000 -0.4357 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 33 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 11 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 34 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 29 1 0 0 0 0 8 35 1 0 0 0 0 11 15 1 0 0 0 0 11 14 2 0 0 0 0 12 14 1 0 0 0 0 12 13 2 0 0 0 0 12 19 1 0 0 0 0 13 16 1 0 0 0 0 13 36 1 0 0 0 0 14 37 1 0 0 0 0 15 16 2 0 0 0 0 15 38 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 18 39 1 0 0 0 0 18 40 1 0 0 0 0 18 41 1 0 0 0 0 19 20 1 0 0 0 0 20 42 1 0 0 0 0 20 43 1 0 0 0 0 20 44 1 0 0 0 0 21 22 1 0 0 0 0 21 45 1 0 0 0 0 22 24 1 0 0 0 0 22 23 2 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 27 1 0 0 0 0 25 28 1 0 0 0 0 26 47 1 0 0 0 0 26 48 1 0 0 0 0 26 49 1 0 0 0 0 27 50 1 0 0 0 0 27 51 1 0 0 0 0 27 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 29 31 1 0 0 0 0 29 56 1 0 0 0 0 30 31 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 30 59 1 0 0 0 0 31 32 2 0 0 0 0 M END > (72) 70 > (72) C23H27N5O4 > (72) 437.4974 > (72) FGFR-P70 > (72) 1,6-naphthyridine deriv. 17 > (72) FGFR-1 Tyrosine Kinase > (72) 25 > (72) BINDDB > (72) <2007 > (72) P > (72) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 7 csChFnd70/04170815452D 40 42 0 0 0 0 0 0 0 0999 V2000 2.4417 6.9422 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2241 6.8582 -0.0158 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8393 7.7103 0.0020 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9033 4.5451 -0.0155 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4637 5.3229 0.0023 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1028 4.4542 0.0101 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4917 2.1743 -0.0153 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8920 2.9286 -0.0252 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1658 2.9431 0.0014 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2189 5.3421 -0.0244 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4665 0.5736 -0.0243 N 0 0 0 0 0 0 0 0 0 0 0 0 3.8814 9.4173 0.0102 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0427 11.8388 -1.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9989 10.2501 -1.0411 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7983 10.1957 1.0736 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8329 11.7846 1.0758 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9595 12.6048 0.0258 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6388 8.7527 -0.0193 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6211 7.6357 -0.0255 N 0 0 3 0 0 0 0 0 0 0 0 0 7.9529 6.8387 -0.0435 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9308 5.4389 -0.0512 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3092 7.5936 -0.0530 N 0 0 3 0 0 0 0 0 0 0 0 0 10.7567 6.7272 -0.0726 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1138 7.8510 -0.0799 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3670 7.5680 0.0299 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.0291 0.0237 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9575 2.2871 -0.0401 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4905 0.0304 -0.0182 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4251 0.0000 -0.0365 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3598 12.4852 -1.8423 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2828 9.6532 -1.8644 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4800 9.5564 1.8943 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5429 12.3889 1.8991 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9904 13.8484 0.0314 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3268 8.7105 -0.0467 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8222 5.9987 0.9476 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8015 6.0104 -1.1021 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0483 8.5795 -1.1001 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0691 8.5679 0.9496 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1908 7.2064 -0.0946 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 25 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 19 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 26 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 27 1 0 0 0 0 11 28 1 0 0 0 0 11 29 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 30 1 0 0 0 0 14 31 1 0 0 0 0 15 16 1 0 0 0 0 15 32 1 0 0 0 0 16 17 2 0 0 0 0 16 33 1 0 0 0 0 17 34 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 20 22 1 0 0 0 0 22 23 1 0 0 0 0 22 35 1 0 0 0 0 23 24 1 0 0 0 0 23 36 1 0 0 0 0 23 37 1 0 0 0 0 24 38 1 0 0 0 0 24 39 1 0 0 0 0 24 40 1 0 0 0 0 M END > (77) 75 > (77) C17H17N5O > (77) 307.3542 > (77) FGFR-P75 > (77) 1,6-naphthyridine deriv. 7 > (77) FGFR-1 Tyrosine Kinase > (77) 1300 > (77) BINDDB > (77) <2007 > (77) P > (77) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 8 csChFnd70/04170815452D 46 48 0 0 0 0 0 0 0 0999 V2000 2.7233 7.7428 0.0126 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8265 7.6490 -0.0176 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2820 8.5994 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3533 5.0692 -0.0173 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7479 5.9367 0.0026 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2300 4.9678 0.0113 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7791 2.4251 -0.0171 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3407 3.2663 -0.0281 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3003 3.2825 0.0015 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8207 5.9581 -0.0272 N 0 0 0 0 0 0 0 0 0 0 0 0 2.7509 0.6398 -0.0271 N 0 0 0 0 0 0 0 0 0 0 0 0 4.3289 10.5032 0.0114 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3936 13.2040 -1.1466 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3448 11.4321 -1.1612 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3516 11.3714 1.1974 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3902 13.1436 1.1998 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 14.0584 0.0288 C 0 0 0 0 0 0 0 0 0 0 0 0 7.4043 9.7621 -0.0216 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3847 8.5163 -0.0284 N 0 0 3 0 0 0 0 0 0 0 0 0 8.8700 7.6273 -0.0486 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8454 6.0660 -0.0572 O 0 0 0 0 0 0 0 0 0 0 0 0 10.3826 8.4693 -0.0591 N 0 0 3 0 0 0 0 0 0 0 0 0 12.0672 6.3807 -1.6928 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5107 8.7564 -0.0891 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9971 7.5030 -0.0809 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0997 6.3625 1.5162 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5247 8.4408 0.0334 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 5.6090 0.0265 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5291 2.5508 -0.0447 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6624 0.0339 -0.0203 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8200 0.0000 -0.0407 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6320 13.9250 -2.0548 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5461 10.7663 -2.0794 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1119 10.6584 2.1128 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1820 13.8176 2.1181 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4506 15.4453 0.0351 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4023 9.7150 -0.0521 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9941 7.1933 -2.8306 H 0 0 0 0 0 0 0 0 0 0 0 0 13.2685 5.6618 -1.7090 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9889 5.4878 -1.6869 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4609 9.5558 1.0592 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7119 8.0374 -0.1055 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4376 9.5689 -1.2269 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0214 5.4695 1.5221 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3010 5.6435 1.5000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0498 7.1620 2.6645 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 27 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 19 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 28 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 29 1 0 0 0 0 11 30 1 0 0 0 0 11 31 1 0 0 0 0 12 14 1 0 0 0 0 12 15 2 0 0 0 0 13 14 2 0 0 0 0 13 17 1 0 0 0 0 13 32 1 0 0 0 0 14 33 1 0 0 0 0 15 16 1 0 0 0 0 15 34 1 0 0 0 0 16 17 2 0 0 0 0 16 35 1 0 0 0 0 17 36 1 0 0 0 0 18 19 1 0 0 0 0 19 20 1 0 0 0 0 20 21 2 0 0 0 0 20 22 1 0 0 0 0 22 25 1 0 0 0 0 22 37 1 0 0 0 0 23 25 1 0 0 0 0 23 38 1 0 0 0 0 23 39 1 0 0 0 0 23 40 1 0 0 0 0 24 25 1 0 0 0 0 24 41 1 0 0 0 0 24 42 1 0 0 0 0 24 43 1 0 0 0 0 25 26 1 0 0 0 0 26 44 1 0 0 0 0 26 45 1 0 0 0 0 26 46 1 0 0 0 0 M END > (78) 76 > (78) C19H21N5O > (78) 335.4078 > (78) FGFR-P76 > (78) 1,6-naphthyridine deriv. 8 > (78) FGFR-1 Tyrosine Kinase > (78) 1900 > (78) BINDDB > (78) <2007 > (78) P > (78) TRAIN $$$$ 1,6-naphthyridine-2,7-diamine deriv. 9 csChFnd70/04170815452D 30 32 0 0 0 0 0 0 0 0999 V2000 2.2598 6.4261 0.0104 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8354 6.3480 -0.0146 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5525 7.1371 0.0019 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6121 4.2066 -0.0144 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2801 4.9268 0.0021 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0206 4.1233 0.0094 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3054 2.0127 -0.0147 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6014 2.7106 -0.0233 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0785 2.7245 0.0009 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8303 4.9441 -0.0226 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2817 0.5312 -0.0229 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5910 8.7166 0.0095 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6564 10.9285 1.2987 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6264 10.9415 -1.2584 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6624 11.6687 0.0237 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1240 7.0652 -0.0236 N 0 0 0 0 0 0 0 0 0 0 0 0 3.5909 9.4697 -1.2727 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6213 9.4566 1.2988 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5470 8.5589 -2.8829 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.6139 8.5295 2.9003 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1.2650 7.0053 0.0277 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 4.6557 0.0224 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5876 2.1168 -0.0371 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3782 0.0285 -0.0174 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1688 0.0000 -0.0342 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6799 11.5026 2.2962 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6260 11.5257 -2.2503 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6900 12.8196 0.0292 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0110 6.5343 -0.0356 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1403 8.0990 -0.0178 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 1 0 0 0 0 1 3 2 0 0 0 0 1 21 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 16 1 0 0 0 0 3 12 1 0 0 0 0 4 10 1 0 0 0 0 4 8 2 0 0 0 0 4 5 1 0 0 0 0 5 6 2 0 0 0 0 6 9 1 0 0 0 0 6 22 1 0 0 0 0 7 9 2 0 0 0 0 7 8 1 0 0 0 0 7 11 1 0 0 0 0 8 23 1 0 0 0 0 11 24 1 0 0 0 0 11 25 1 0 0 0 0 12 18 1 0 0 0 0 12 17 2 0 0 0 0 13 18 2 0 0 0 0 13 15 1 0 0 0 0 13 26 1 0 0 0 0 14 17 1 0 0 0 0 14 15 2 0 0 0 0 14 27 1 0 0 0 0 15 28 1 0 0 0 0 16 29 1 0 0 0 0 16 30 1 0 0 0 0 17 19 1 0 0 0 0 18 20 1 0 0 0 0 M END > (79) 77 > (79) C14H10Cl2N4 > (79) 305.1658 > (79) FGFR-P77 > (79) 1,6-naphthyridine deriv. 9 > (79) FGFR-1 Tyrosine Kinase > (79) 2800 > (79) BINDDB > (79) <2007 > (79) P > (79) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7f csChFnd70/04170815452D 58 60 0 0 0 0 0 0 0 0999 V2000 1.1433 15.4211 0.5774 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3711 12.6557 0.3633 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0302 13.3286 0.0426 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7694 16.2099 0.2622 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2510 15.1351 -0.0123 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9437 18.0555 0.2145 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5572 18.7717 -0.0991 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0667 17.6197 -0.3782 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5069 18.2496 -0.6567 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0040 13.7034 0.6162 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8692 15.8659 -0.3262 N 0 0 3 0 0 0 0 0 0 0 0 0 7.3896 14.7276 -0.6069 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7759 20.6998 -0.1563 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3776 23.4221 1.3071 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1755 21.6246 1.3697 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5904 21.5984 -1.7381 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7959 23.3961 -1.7827 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1853 24.3056 -0.2638 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4175 20.5182 3.3426 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.1032 20.4591 -3.6461 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.1357 10.8540 0.4203 N 0 0 3 0 0 0 0 0 0 0 0 0 3.6306 9.6815 0.1439 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0187 7.7767 0.2732 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5798 6.5521 -0.0153 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9680 4.6473 0.1139 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4668 3.4715 -0.1632 N 0 0 0 0 0 0 0 0 0 0 0 0 6.7479 3.6389 1.2639 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4820 2.8005 0.7073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8856 1.6468 -0.3579 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1023 1.3863 -2.1850 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.2260 0.7953 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1312 12.4627 -0.1604 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8178 18.8877 0.4225 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5147 14.4351 -1.9993 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5706 15.3896 -0.1515 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2149 13.5114 0.1214 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6864 24.1394 2.4875 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6527 24.0931 -3.0059 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3445 25.7113 -0.3057 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9816 10.3706 0.6431 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1868 9.9161 -1.1506 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6226 9.9317 1.1407 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4626 7.5420 1.5678 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0267 7.5265 -0.7237 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1361 6.7868 -1.3099 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5718 6.8023 0.9816 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4117 4.4127 1.4084 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9760 4.3971 -0.8830 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9590 5.0215 1.5545 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2518 2.9779 2.4290 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4113 2.8653 1.7899 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2583 1.4352 0.3525 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0114 3.5040 -0.4175 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0012 0.7711 -0.1888 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8965 1.3542 0.6303 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8898 2.1335 -2.2942 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0314 1.8400 -3.1704 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8275 0.0000 -2.3921 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 31 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 32 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 33 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 34 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 37 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 38 1 0 0 0 0 18 39 1 0 0 0 0 21 22 1 0 0 0 0 21 40 1 0 0 0 0 22 23 1 0 0 0 0 22 41 1 0 0 0 0 22 42 1 0 0 0 0 23 24 1 0 0 0 0 23 43 1 0 0 0 0 23 44 1 0 0 0 0 24 25 1 0 0 0 0 24 45 1 0 0 0 0 24 46 1 0 0 0 0 25 26 1 0 0 0 0 25 47 1 0 0 0 0 25 48 1 0 0 0 0 26 29 1 0 0 0 0 26 27 1 0 0 0 0 27 28 1 0 0 0 0 27 49 1 0 0 0 0 27 50 1 0 0 0 0 28 51 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 30 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 M END > (9) 7 > (9) C23H28Cl2N4O > (9) 447.4064 > (9) FGFR-P7 > (9) 1,6-naphthyridin-2(1H)-one deriv. 7f > (9) FGFR-1 Tyrosine Kinase > (9) 80 > (9) BINDDB > (9) <2007 > (9) P > (9) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7g csChFnd70/04170815452D 61 63 0 0 0 0 0 0 0 0999 V2000 1.3379 15.9479 2.7342 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2265 13.5875 2.1921 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7272 14.6188 2.4674 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7779 17.0823 3.0336 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5177 16.3995 2.8964 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5127 18.8899 3.4667 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9576 19.9522 3.7473 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7438 19.2019 3.5946 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0354 20.1408 3.8443 O 0 0 0 0 0 0 0 0 0 0 0 0 1.6077 14.2713 2.3314 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9639 17.4764 3.1814 N 0 0 3 0 0 0 0 0 0 0 0 0 7.7572 16.7416 3.0331 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7174 21.8495 4.2021 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3541 24.1416 6.3879 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5780 22.3707 5.9732 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6368 23.1239 2.8613 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4126 24.8902 3.2943 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2684 25.3973 5.0523 C 0 0 0 0 0 0 0 0 0 0 0 0 3.6854 20.7967 7.6513 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.8190 22.4905 0.6543 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.4204 11.8084 1.7627 N 0 0 3 0 0 0 0 0 0 0 0 0 5.1968 11.0350 1.6041 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0384 9.0691 1.1232 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8933 8.2614 0.9578 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7349 6.2954 0.4770 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5899 5.4879 0.3114 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4378 3.6003 -0.1502 N 0 0 0 0 0 0 0 0 0 0 0 0 10.1748 2.8559 -0.6275 C 0 0 0 0 0 0 0 0 0 0 0 0 10.6832 3.4681 -2.4950 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6200 2.5898 1.3019 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0250 0.7756 0.6124 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.4499 2.8401 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0358 14.0467 2.3505 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1872 19.4239 3.5741 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2241 16.8803 1.6715 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6460 17.4562 3.9226 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7361 15.3418 3.3954 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2457 24.5466 7.7581 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3501 25.8779 2.2581 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0933 26.7803 5.3837 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3801 11.0764 1.5671 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9330 11.7265 0.5692 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8948 11.1685 2.8636 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3020 8.3775 2.1582 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3401 8.9356 -0.1363 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6297 8.9530 -0.0771 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5914 8.3948 2.2173 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9985 5.6039 1.5119 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0369 6.1620 -0.7825 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3262 6.1793 -0.7235 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2878 5.6213 1.5709 H 0 0 0 0 0 0 0 0 0 0 0 0 11.1705 3.3115 0.3170 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1054 1.4116 -0.5958 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6069 3.1640 -3.4118 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9208 4.8945 -2.4867 H 0 0 0 0 0 0 0 0 0 0 0 0 11.8841 2.7817 -2.9169 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5830 2.4091 2.3657 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4740 3.3131 1.8070 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4796 0.0000 1.7047 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0122 0.9547 -0.4043 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1589 0.0795 0.0460 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 25 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 27 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 28 29 1 0 0 0 0 28 52 1 0 0 0 0 28 53 1 0 0 0 0 29 54 1 0 0 0 0 29 55 1 0 0 0 0 29 56 1 0 0 0 0 30 31 1 0 0 0 0 30 57 1 0 0 0 0 30 58 1 0 0 0 0 31 59 1 0 0 0 0 31 60 1 0 0 0 0 31 61 1 0 0 0 0 M END > (10) 8 > (10) C24H30Cl2N4O > (10) 461.4332 > (10) FGFR-P8 > (10) 1,6-naphthyridin-2(1H)-one deriv. 7g > (10) FGFR-1 Tyrosine Kinase > (10) 80 > (10) BINDDB > (10) <2007 > (10) P > (10) TRAIN $$$$ 1,6-naphthyridin-2(1H)-one deriv. 7h csChFnd70/04170815452D 58 61 0 0 0 0 0 0 0 0999 V2000 1.2249 16.2607 0.0121 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7195 13.6546 -0.0162 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3207 14.4808 -0.0271 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7817 17.1980 0.0022 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3707 16.2836 -0.0179 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7815 19.0349 0.0108 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3330 19.8992 -0.0006 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9572 18.9115 -0.0214 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3424 19.6738 -0.0304 O 0 0 0 0 0 0 0 0 0 0 0 0 1.2481 14.5535 0.0026 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9253 17.1626 -0.0286 N 0 0 3 0 0 0 0 0 0 0 0 0 7.5589 16.1896 -0.0488 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3696 21.8219 0.0073 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4364 24.5169 1.5756 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4024 22.7246 1.5773 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3791 22.7379 -1.5552 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4133 24.5303 -1.5388 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4387 25.4173 0.0222 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3994 21.5970 3.5283 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.3489 21.6271 -3.5155 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.6546 11.8552 -0.0260 N 0 0 3 0 0 0 0 0 0 0 0 0 4.2662 10.8457 -0.0467 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8331 8.9076 -0.0537 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5160 7.8534 -0.0755 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7603 5.5868 1.2134 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2910 3.6599 1.0945 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1963 3.0146 0.0875 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6655 4.9413 0.2064 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1003 5.9925 -0.0823 N 0 0 0 0 0 0 0 0 0 0 0 0 4.8565 2.6088 1.3830 N 0 0 0 0 0 0 0 0 0 0 0 0 4.4408 0.7479 1.3764 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 16.9421 0.0332 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5076 13.7350 -0.0421 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5729 19.7449 0.0257 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9513 15.9545 -1.3877 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5616 16.9375 0.6121 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3793 14.9526 0.6141 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4611 25.2172 2.7898 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4207 25.2408 -2.7471 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4653 26.8189 0.0279 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5424 11.2653 -0.0188 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0090 11.1673 -1.2071 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0307 11.1541 1.1030 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0901 8.5862 1.1067 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0686 8.5993 -1.2036 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2589 8.1748 -1.2359 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2805 8.1617 1.0743 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6087 6.3695 0.9625 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2536 5.8734 2.5081 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3247 3.3479 2.0795 H 0 0 0 0 0 0 0 0 0 0 0 0 2.7648 3.3806 -0.1888 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7032 2.7279 -1.2073 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3479 2.2319 0.3383 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1917 5.2206 1.4896 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6320 5.2534 -0.7787 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8810 0.3942 0.1260 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6221 0.0000 1.5926 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5107 0.4687 2.4053 H 0 0 0 0 0 0 0 0 0 0 0 0 1 10 1 0 0 0 0 1 4 2 0 0 0 0 1 32 1 0 0 0 0 2 10 2 0 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 3 5 2 0 0 0 0 3 33 1 0 0 0 0 4 6 1 0 0 0 0 4 5 1 0 0 0 0 5 11 1 0 0 0 0 6 7 2 0 0 0 0 6 34 1 0 0 0 0 7 8 1 0 0 0 0 7 13 1 0 0 0 0 8 11 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 35 1 0 0 0 0 12 36 1 0 0 0 0 12 37 1 0 0 0 0 13 15 1 0 0 0 0 13 16 2 0 0 0 0 14 15 2 0 0 0 0 14 18 1 0 0 0 0 14 38 1 0 0 0 0 15 19 1 0 0 0 0 16 17 1 0 0 0 0 16 20 1 0 0 0 0 17 18 2 0 0 0 0 17 39 1 0 0 0 0 18 40 1 0 0 0 0 21 22 1 0 0 0 0 21 41 1 0 0 0 0 22 23 1 0 0 0 0 22 42 1 0 0 0 0 22 43 1 0 0 0 0 23 24 1 0 0 0 0 23 44 1 0 0 0 0 23 45 1 0 0 0 0 24 29 1 0 0 0 0 24 46 1 0 0 0 0 24 47 1 0 0 0 0 25 29 1 0 0 0 0 25 26 1 0 0 0 0 25 48 1 0 0 0 0 25 49 1 0 0 0 0 26 30 1 0 0 0 0 26 50 1 0 0 0 0 26 51 1 0 0 0 0 27 30 1 0 0 0 0 27 28 1 0 0 0 0 27 52 1 0 0 0 0 27 53 1 0 0 0 0 28 29 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 30 31 1 0 0 0 0 31 56 1 0 0 0 0 31 57 1 0 0 0 0 31 58 1 0 0 0 0 M END > (11) 9 > (11) C23H27Cl2N5O > (11) 460.4052 > (11) FGFR-P9 > (11) 1,6-naphthyridin-2(1H)-one deriv. 7h > (11) FGFR-1 Tyrosine Kinase > (11) 170 > (11) BINDDB > (11) <2007 > (11) P > (11) TRAIN $$$$