TTD - Therapeutic Targets Database Full Data Download File Title - Wiki pathway data for TTD patented targets only Version 7.1.01 (2019.07.14) Provided by IDRB Lab of Innovative Drug Reasearch and Bioinformatics College of Pharmaceutical Sciences Zhejiang University https://idrblab.org/ Provided by BIDD BioInformatic and Drug Design Group Department of Pharmacy National Unviersity of Singapore http://bidd.nus.edu.sg/ Any question about data provided here, please contact with: Dr. Wang (lfwyx@zju.edu.cn) and Dr. Li (lifengcheng@zju.edu.cn) -------------------------------------------------------------------------------------------------------- TTDID Wiki pathway ID Wiki pathway name T00663 WP75 Toll-like receptor signaling pathway T00663 WP710 DNA Damage Response (only ATM dependent) T00663 WP524 G13 Signaling Pathway T00663 WP481 Insulin Signaling T00663 WP428 Wnt Signaling Pathway T00663 WP422 MAPK Cascade T00663 WP408 Oxidative Stress T00663 WP399 Wnt Signaling Pathway and Pluripotency T00663 WP384 Apoptosis Modulation by HSP70 T00663 WP382 MAPK Signaling Pathway T00663 WP2643 Nanoparticle-mediated activation of receptor signaling T00663 WP2637 Structural Pathway of Interleukin 1 (IL-1) T00663 WP254 Apoptosis T00663 WP2380 BDNF signaling pathway T00663 WP185 Integrin-mediated Cell Adhesion T00663 WP1449 Regulation of toll-like receptor signaling pathway T03818 WP363 Wnt Signaling Pathway Netpath T03818 WP299 Nuclear Receptors in Lipid Metabolism and Toxicity T03818 WP2895 Differentiation of white and brown adipocyte T03818 WP2797 Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) T03818 WP2751 Transcriptional Regulation of White Adipocyte Differentiation T03818 WP236 Adipogenesis T03818 WP1982 SREBP signalling T03818 WP170 Nuclear Receptors T07217 WP2764 Lipid digestion, mobilization, and transport T07217 WP2751 Transcriptional Regulation of White Adipocyte Differentiation T10822 WP2797 Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) T10822 WP2755 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer T10822 WP2751 Transcriptional Regulation of White Adipocyte Differentiation T10822 WP2720 Signaling by NOTCH1 T10822 WP1982 SREBP signalling T10822 WP1822 Generic Transcription Pathway T15700 WP75 Toll-like receptor signaling pathway T15700 WP707 DNA Damage Response T15700 WP384 Apoptosis Modulation by HSP70 T15700 WP314 FAS pathway and Stress induction of HSP regulation T15700 WP2752 MyD88-independent cascade T15700 WP254 Apoptosis T15700 WP2513 Nanoparticle triggered regulated necrosis T15700 WP2377 Integrated Pancreatic Cancer Pathway T15700 WP2359 Parkin-Ubiquitin Proteasomal System pathway T15700 WP2328 Allograft Rejection T15700 WP2324 AGE/RAGE pathway T15700 WP231 TNF alpha Signaling Pathway T15700 WP2263 Prostate Cancer T15700 WP2059 Alzheimers Disease T15700 WP2036 TWEAK Signaling Pathway T15700 WP1984 Integrated Breast Cancer Pathway T15700 WP1971 Integrated Cancer pathway T15700 WP1904 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways T15700 WP1841 Intrinsic Pathway for Apoptosis T15700 WP1814 Extrinsic Pathway for Apoptosis T15700 WP1784 Apoptotic execution phase T15700 WP1772 Apoptosis Modulation and Signaling T15700 WP1530 miRNA Regulation of DNA Damage Response T15700 WP1449 Regulation of toll-like receptor signaling pathway T15700 WP1433 NOD pathway T16042 WP2650 Arachidonic acid metabolism T16042 WP167 Eicosanoid Synthesis T20973 WP707 DNA Damage Response T20973 WP2380 BDNF signaling pathway T20973 WP2059 Alzheimers Disease T20973 WP1978 Opioid Signalling T20973 WP1907 Semaphorin interactions T20973 WP1815 Factors involved in megakaryocyte development and platelet production T20973 WP1602 Nicotine Activity on Dopaminergic Neurons T20973 WP1530 miRNA Regulation of DNA Damage Response T28887 WP2377 Integrated Pancreatic Cancer Pathway T28887 WP2064 Neural Crest Differentiation T28887 WP179 Cell Cycle T30803 WP702 Metapathway biotransformation T30803 WP692 Sulfation Biotransformation Reaction T30803 WP408 Oxidative Stress T30803 WP2884 NRF2 pathway T30803 WP2882 Nuclear Receptors Meta-Pathway T30803 WP15 Selenium Micronutrient Network T30803 WP100 Glutathione metabolism T46685 WP411 mRNA Processing T51385 WP2728 Incretin Synthesis, Secretion, and Inactivation T51385 WP1825 GPCR ligand binding T62841 WP455 GPCRs, Class A Rhodopsin-like T62841 WP2664 Gastrin-CREB signalling pathway via PKC and MAPK T62841 WP1825 GPCR ligand binding T62841 WP1824 GPCR downstream signaling T64205 WP75 Toll-like receptor signaling pathway T64205 WP619 Type II interferon signaling (IFNG) T64205 WP585 Interferon type I signaling pathways T64205 WP581 EPO Receptor Signaling T64205 WP560 TGF Beta Signaling Pathway T64205 WP49 IL-2 Signaling Pathway T64205 WP474 Endochondral Ossification T64205 WP437 EGF/EGFR Signaling Pathway T64205 WP400 p38 MAPK Signaling Pathway T64205 WP395 IL-4 Signaling Pathway T64205 WP364 IL-6 signaling pathway T64205 WP304 Kit receptor signaling pathway T64205 WP2853 Endoderm Differentiation T64205 WP2713 Signaling by SCF-KIT T64205 WP2593 JAK/STAT T64205 WP2526 PDGF Pathway T64205 WP2380 BDNF signaling pathway T64205 WP2377 Integrated Pancreatic Cancer Pathway T64205 WP2374 Oncostatin M Signaling Pathway T64205 WP236 Adipogenesis T64205 WP2332 Interleukin-11 Signaling Pathway T64205 WP2328 Allograft Rejection T64205 WP2324 AGE/RAGE pathway T64205 WP2263 Prostate Cancer T64205 WP2203 TSLP Signaling Pathway T64205 WP22 IL-9 Signaling Pathway T64205 WP2113 Type III interferon signaling T64205 WP205 IL-7 Signaling Pathway T64205 WP2034 Leptin signaling pathway T64205 WP2032 TSH signaling pathway T64205 WP2018 RANKL/RANK Signaling Pathway T64205 WP1984 Integrated Breast Cancer Pathway T64205 WP1971 Integrated Cancer pathway T64205 WP1916 Signaling by PDGF T64205 WP1449 Regulation of toll-like receptor signaling pathway T64205 WP127 IL-5 Signaling Pathway T69375 WP75 Toll-like receptor signaling pathway T69375 WP710 DNA Damage Response (only ATM dependent) T69375 WP69 TCR Signaling Pathway T69375 WP560 TGF Beta Signaling Pathway T69375 WP481 Insulin Signaling T69375 WP437 EGF/EGFR Signaling Pathway T69375 WP428 Wnt Signaling Pathway T69375 WP399 Wnt Signaling Pathway and Pluripotency T69375 WP382 MAPK Signaling Pathway T69375 WP366 TGF beta Signaling Pathway T69375 WP2643 Nanoparticle-mediated activation of receptor signaling T69375 WP2637 Structural Pathway of Interleukin 1 (IL-1) T69375 WP2593 JAK/STAT T69375 WP2516 ATM Signaling Pathway T69375 WP2380 BDNF signaling pathway T69375 WP2377 Integrated Pancreatic Cancer Pathway T69375 WP2374 Oncostatin M Signaling Pathway T69375 WP2355 Corticotropin-releasing hormone T69375 WP2324 AGE/RAGE pathway T69375 WP231 TNF alpha Signaling Pathway T69375 WP23 B Cell Receptor Signaling Pathway T69375 WP2203 TSLP Signaling Pathway T69375 WP2036 TWEAK Signaling Pathway T69375 WP2018 RANKL/RANK Signaling Pathway T69375 WP195 IL-1 signaling pathway T69375 WP1449 Regulation of toll-like receptor signaling pathway T75386 WP716 Vitamin A and Carotenoid Metabolism T75386 WP430 Statin Pathway T75386 WP325 Triacylglyceride Synthesis T75386 WP2740 Glycerophospholipid biosynthesis T75386 WP1817 Fatty acid, triacylglycerol, and ketone body metabolism T79155 WP2840 Hair Follicle Development: Cytodifferentiation (Part 3 of 3) T85250 WP500 Glycogen Metabolism T85250 WP481 Insulin Signaling T85250 WP363 Wnt Signaling Pathway Netpath T85250 WP2667 Activation of Chaperone Genes by XBP1(S) T85250 WP2583 T-Cell Receptor and Co-stimulatory Signaling T85250 WP2377 Integrated Pancreatic Cancer Pathway T85250 WP23 B Cell Receptor Signaling Pathway T85250 WP2034 Leptin signaling pathway T85250 WP1984 Integrated Breast Cancer Pathway T85250 WP1982 SREBP signalling T85250 WP127 IL-5 Signaling Pathway T86702 WP2769 Activation of Matrix Metalloproteinases T86702 WP2664 Gastrin-CREB signalling pathway via PKC and MAPK T86702 WP2374 Oncostatin M Signaling Pathway T86702 WP129 Matrix Metalloproteinases T93653 WP474 Endochondral Ossification T98062 WP500 Glycogen Metabolism T98062 WP1848 Metabolism of carbohydrates T98459 WP707 DNA Damage Response T98459 WP45 G1 to S cell cycle control T98459 WP2654 Mitotic Prophase T98459 WP2652 Mitotic Prometaphase T98459 WP2516 ATM Signaling Pathway T98459 WP2446 Retinoblastoma (RB) in Cancer T98459 WP1859 Mitotic G2-G2/M phases T98459 WP1858 Mitotic G1-G1/S phases T98459 WP179 Cell Cycle T98459 WP1782 APC/C-mediated degradation of cell cycle proteins T98459 WP1775 Cell Cycle Checkpoints T98459 WP1530 miRNA Regulation of DNA Damage Response T98459 WP1403 AMPK Signaling