Target expression details
| Target General Information | |||||
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| Target ID | T51666 | ||||
| Target Name | Potassium-transporting ATPase alpha 1 | ||||
| Synonyms | Gastric H(+)/K(+)-ATPase; Gastric H+/K+ ATPase alpha subunit; Proton pump; ATP4A | ||||
| Target Type | Successful | ||||
| Gene Name | ATP4A | ||||
| Biochemical Class | Acid anhydrides hydrolase | ||||
| UniProt ID | ATP4A_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Ulcerative colitis | ||||
| Example drug | AG-SPT201 | Phase 3 | [523556], [1572592] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.08 Z-score: 0.38 P-value: 2.18E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of the persons with other diseases not directly affecting the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Eosinophilic gastritis | ||||
| Tissue | Gastric antrum tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: -0.88 Z-score: -0.44 P-value: 7.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Rectal cancer | ||||
| Tissue | Rectal colon tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.15 Z-score: -1.50 P-value: 1.42E-02 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.04 Z-score: 0.13 P-value: 5.20E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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