Target expression details

Target General Information
Target ID T81850
Target Name Squalene synthase
Synonyms FPP:FPP farnesyltransferase; SQS; SS; Squalene synthase; Squalene synthetase; FDFT1
Target Type Discontinued
Gene Name FDFT1
Biochemical Class Alkyl aryl transferase
UniProt ID FDFT_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Arteriosclerosis
Example drug SQ-32709 Discontinued in Phase 2 [545908], [1572592]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.09
Z-score: 0.73
P-value: 4.16E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Disease Familial hypercholesterolemia
Tissue Whole blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.09
Z-score: -0.38
P-value: 7.85E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Download target gene expression data of the patients in the disease section of the tissue
Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 545908Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005302)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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