Target Information

Target General Infomation
Target ID
T83376
Former ID
TTDI02202
Target Name
Tumor suppressor candidate 2
Gene Name
TUSC2
Synonyms
Fus-1 protein; Fusion 1 protein; PDGFA-associated protein 2; TUSC2
Target Type
Clinical Trial
Disease Non-small cell lung cancer [ICD10: C33-C34]
Function
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
BioChemical Class
Tumour suppressor candidate 2
UniProt ID
O75896
Sequence
MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLA
HEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV
Drugs and Mode of Action
Drug(s) CNVN-202 Drug Info Phase 1/2 Non-small cell lung cancer [547714]
Fus-1 tumor suppressor gene therapy - nanoparticle formulation Drug Info Phase 1/2 Non-small cell lung cancer [547714]
Suppressor CNVN-202 Drug Info [547713]
Fus-1 tumor suppressor gene therapy - nanoparticle formulation Drug Info [528811]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
References
Ref 547714Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018766)
Ref 528811INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201. Drugs R D. 2007;8(3):176-87.
Ref 547713Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018766)

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