Target Information

Target General Infomation
Target ID
T99347
Former ID
TTDC00100
Target Name
Metabotropic glutamate receptor 5
Gene Name
GRM5
Synonyms
5b; Glutamate receptor mGLU5; mGluR5; GRM5
Target Type
Clinical Trial
Disease Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42]
Autism [ICD9: 299; ICD10: F84.0]
Alzheimer disease [ICD9: 331; ICD10: G30]
Central nervous system disease [ICD10: G00-G99]
Chronic neuropathic pain [ICD9: 338, 356.0, 356.8, 530,780; ICD10: G64, G90.0, K21, R52, G89]
Fragile X syndrome [ICD9: 332, 759.83; ICD10: F02.3, G20, Q99.2]
Major depressive disorder; GERD; Chronic neuropathic pain [ICD9: 296.2, 296.3, 338, 356.0, 356.8, 530,780; ICD10: F32, F33, G64, G90.0, K21, R52, G89]
Mood disorder [ICD10: F30-F39]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32]
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89]
Neuropathic pain; Migraine [ICD9: 338, 346,780; ICD10: G43, R52, G89]
Unspecified [ICD code not available]
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
BioChemical Class
GPCR glutamate
Target Validation
T99347
UniProt ID
P41594
Sequence
MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV
REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS
EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS
DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI
CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL
LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ
HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP
GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD
YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN
EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV
FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS
ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM
HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT
TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS
TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG
NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG
LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS
PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML
STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA
RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL
IIRDYTQSSSSL
Drugs and Mode of Action
Drug(s) AFQ056 Drug Info Phase 2/3 Fragile X syndrome [523621], [542576]
ADX-48621 Drug Info Phase 2 Mood disorder [523431], [541593]
ADX10059 Drug Info Phase 2 Anxiety disorder [522540]
RG-7090 Drug Info Phase 2 Fragile X syndrome [524162]
STX-107 Drug Info Phase 2 Autism [523414], [540295]
McN3377 Drug Info Phase 1/2 Fragile X syndrome [522263], [538912]
MK-3328 Drug Info Phase 1 Alzheimer disease [522751]
AZD2066 Drug Info Discontinued in Phase 2 Major depressive disorder; GERD; Chronic neuropathic pain [548676]
AZD2516 Drug Info Discontinued in Phase 2 Chronic neuropathic pain [548860]
LY467711 Drug Info Terminated Neuropathic pain; Migraine [547372]
LY525327 Drug Info Terminated Neuropathic pain; Migraine [547372]
Antagonist (+)-MCPG Drug Info [525911]
(S)-4C3HPG Drug Info [525911]
(S)-4CPG Drug Info [525911]
ACDPP Drug Info [527417]
AZD2066 Drug Info [550288]
AZD2516 Drug Info [550288]
CTEP Drug Info [543750]
GSK-2210875 Drug Info [543750]
LY467711 Drug Info [536166]
LY525327 Drug Info [536166]
MGluR5 antagonists (anxiety), Novartis Drug Info [543750]
RG-7090 Drug Info [544380]
RTI-4229-982 Drug Info [543750]
STX-107 Drug Info [544372]
Agonist (1S,3R)-ACPD Drug Info [525911]
(S)-(+)-CBPG Drug Info [525552]
(S)-3HPG Drug Info [525911]
3,5-DHPG Drug Info [525911]
CHPG Drug Info [525911]
ibotenate Drug Info [525911]
L-CCG-I Drug Info [525911]
Inhibitor (3-(2-methylquinolin-7-yl)phenyl)methanol Drug Info [528922]
(3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine Drug Info [527656]
(E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone Drug Info [530245]
(E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine Drug Info [528003]
1-(3-(2-methylquinolin-7-yl)phenyl)ethanone Drug Info [528922]
2-(2-Methyl-thiazol-4-ylethynyl)-pyridine Drug Info [527127]
2-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
2-(3,4-dimethylphenyl)-1,8-naphthyridine Drug Info [529101]
2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine Drug Info [528998]
2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine Drug Info [529101]
2-(3,5-dimethoxyphenyl)-1,8-naphthyridine Drug Info [529101]
2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile Drug Info [528922]
2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine Drug Info [528311]
2-(3-(benzyloxy)phenyl)isoindoline-1,3-dione Drug Info [527989]
2-(3-bromophenyl)-7-methyl-1,8-naphthyridine Drug Info [529101]
2-(3-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine Drug Info [528998]
2-(3-bromophenyl)pyrido[2,3-d]pyrimidine Drug Info [528998]
2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile Drug Info [527989]
2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine Drug Info [529101]
2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine Drug Info [528307]
2-(m-tolylethynyl)pyrimidine Drug Info [530217]
2-(phenylethynyl)pyrimidine Drug Info [530217]
2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine Drug Info [528038]
2-Benzoxy-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [530843]
2-benzyloxy-7,8-dihydro-6H-quinolin-5-one Drug Info [529241]
2-bromo-4-(3-fluorophenylethynyl)thiazole Drug Info [528003]
2-Chloro-5-(2-methylquinolin-7-yl)nicotinonitrile Drug Info [530843]
2-chloro-N-(3-(3-chlorobenzamido)phenyl)benzamide Drug Info [530486]
2-Cyclohex-1-enylethynyl-pyridine Drug Info [527696]
2-Cyclohexylethynyl-pyridine Drug Info [527696]
2-Cyclopent-1-enylethynyl-pyridine Drug Info [527696]
2-ethoxy-5-(m-tolylethynyl)pyrimidine Drug Info [530217]
2-ethynyl-4-(3-fluorophenylethynyl)thiazole Drug Info [528003]
2-m-tolyl-1,8-naphthyridine Drug Info [529101]
2-methyl-4-(2-thienylethynyl)thiazole Drug Info [528003]
2-methyl-4-(3-thienylethynyl)thiazole Drug Info [528003]
2-methyl-4-(m-tolylethynyl)thiazole Drug Info [528003]
2-methyl-4-(pyridin-3-ylethynyl)thiazole Drug Info [530843]
2-Methyl-4-o-tolylethynyl-thiazole Drug Info [527127]
2-Methyl-4-p-tolylethynyl-thiazole Drug Info [527127]
2-Methyl-4-phenylethynyl-thiazole Drug Info [527127]
2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine Drug Info [528525]
2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine Drug Info [528311]
2-methyl-6-(3-(phenylthio)prop-1-ynyl)pyridine Drug Info [528307]
2-methyl-6-(4-phenylbut-1-ynyl)pyridine Drug Info [528307]
2-methyl-6-(4-phenylpent-1-ynyl)pyridine Drug Info [528307]
2-methyl-6-(5-phenylpent-1-ynyl)pyridine Drug Info [528307]
2-methyl-6-(phenylethynyl)pyridine Drug Info [530473]
2-methyl-7-(pyridin-3-yl)quinoline Drug Info [528922]
2-methyl-7-m-tolyl-1,6-naphthyridine Drug Info [529101]
2-methyl-7-m-tolyl-1,8-naphthyridine Drug Info [529101]
2-methyl-7-m-tolylquinoline Drug Info [528922]
2-methyl-7-phenyl-1,8-naphthyridine Drug Info [529101]
2-methyl-7-phenylquinoline Drug Info [528922]
2-phenyl-1,8-naphthyridine Drug Info [529101]
2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine Drug Info [530140]
2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol Drug Info [529241]
2-phenylethynyl-5,6,7,8-tetrahydro-quinoline Drug Info [529241]
2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one Drug Info [529241]
2-[(2-methyl-4-thiazolyl)ethynyl]pyrazine Drug Info [528003]
3-(1,5-naphthyridin-3-yl)benzonitrile Drug Info [529101]
3-(1,8-naphthyridin-2-yl)benzonitrile Drug Info [529101]
3-(1-Pyridin-2-yl-1H-pyrazol-3-yl)-benzonitrile Drug Info [527190]
3-(1-Pyridin-2-yl-1H-pyrazol-4-yl)-benzonitrile Drug Info [527190]
3-(1-Pyridin-2-yl-1H-pyrrol-3-yl)-benzonitrile Drug Info [527190]
3-(2-methylbenzo[d]thiazol-5-yl)benzonitrile Drug Info [528793]
3-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-(2-methylquinolin-7-yl)phenol Drug Info [528922]
3-(2-Pyridin-2-yl-2H-tetrazol-5-yl)-benzonitrile Drug Info [527190]
3-(3,4-dimethylphenyl)-1,5-naphthyridine Drug Info [529101]
3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine Drug Info [527989]
3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine Drug Info [528893]
3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine Drug Info [528893]
3-(3-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile Drug Info [527190]
3-(3-Pyridin-2-yl-pyrrol-1-yl)-benzonitrile Drug Info [527190]
3-(4-Pyridin-2-yl-imidazol-1-yl)-benzonitrile Drug Info [527190]
3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile Drug Info [527190]
3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile Drug Info [527190]
3-(6-fluoroquinazolin-4-ylamino)benzonitrile Drug Info [530473]
3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile Drug Info [529101]
3-biphenyl-4-ylethynyl-5-methyl-[1,2,4]triazine Drug Info [528893]
3-bromo-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine Drug Info [528003]
3-bromo-N-(6-methylpyridin-2-yl)benzamide Drug Info [528186]
3-chloro-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-chloro-N-(3-isobutyramidophenyl)benzamide Drug Info [530486]
3-chloro-N-(4-methylthiazol-2-yl)benzamide Drug Info [528186]
3-chloro-N-(6-chloropyridin-2-yl)benzamide Drug Info [528186]
3-chloro-N-(6-methylpyridin-2-yl)benzamide Drug Info [530140]
3-cyano-5-fluoro-N-(3-fluorophenyl)benzamide Drug Info [531010]
3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide Drug Info [531010]
3-cyano-5-fluoro-N-m-tolylbenzamide Drug Info [531010]
3-cyano-5-fluoro-N-phenylbenzamide Drug Info [531010]
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
3-cyano-N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide Drug Info [531010]
3-cyano-N-(3-ethylphenyl)-5-fluorobenzamide Drug Info [531010]
3-cyano-N-(3-ethynylphenyl)-5-fluorobenzamide Drug Info [531010]
3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide Drug Info [531010]
3-cyano-N-(6-methylpyridin-2-yl)benzamide Drug Info [530140]
3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile Drug Info [529101]
3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-iodo-N-(6-methylpyridin-2-yl)benzamide Drug Info [528186]
3-isobutoxy-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-m-tolyl-1,5-naphthyridine Drug Info [529101]
3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile Drug Info [529101]
3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile Drug Info [529101]
3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-methoxy-N-(4-methylthiazol-2-yl)benzamide Drug Info [528186]
3-methoxy-N-(6-methylpyridin-2-yl)benzamide Drug Info [528186]
3-methyl-5-(2-methylquinolin-7-yl)benzonitrile Drug Info [528922]
3-methyl-N-(6-methylpyridin-2-yl)benzamide Drug Info [528186]
3-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene Drug Info [530140]
3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine Drug Info [528003]
3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine Drug Info [528003]
3-[(2-methyl-4-thiazolyl)ethynyl]benzamide Drug Info [528003]
3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile Drug Info [528003]
3-[(2-methyl-4-thiazolyl)ethynyl]phenol Drug Info [528003]
3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine Drug Info [528003]
3-[(6-Methylpyridin-2-yl)ethynyl]benzonitrile Drug Info [530140]
4-(2-(3-fluorophenyl)ethynyl)-2-methylthiazole Drug Info [528003]
4-(2-(4-fluorophenyl)ethynyl)-2-methylthiazole Drug Info [528003]
4-(2-fluorophenylethynyl)-2-methylthiazole Drug Info [528003]
4-(2-methoxyphenylethynyl)-2-methylthiazole Drug Info [528003]
4-(2-Methyl-thiazol-4-ylethynyl)-pyridine Drug Info [527127]
4-(3,5-difluorophenylethynyl)-2-methylthiazole Drug Info [528003]
4-(3-bromophenoxy)-6-chloroquinazoline Drug Info [530473]
4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine Drug Info [528038]
4-(3-chlorophenylethynyl)-2-methylthiazole Drug Info [528003]
4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine Drug Info [528038]
4-(3-fluorophenylethynyl)-2-thiazolylamine Drug Info [528003]
4-(3-methoxyphenylethynyl)-2-methylthiazole Drug Info [528003]
4-(3-pyridylethynyl)-2-thiazolylamine Drug Info [528003]
4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine Drug Info [528038]
4-Biphenyl-2-ylethynyl-2-methyl-thiazole Drug Info [527127]
4-Biphenyl-4-ylethynyl-2-methyl-thiazole Drug Info [527127]
4-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile Drug Info [530843]
5-(2-(2,5-dimethylphenyl)ethynyl)pyrimidine Drug Info [529531]
5-(2-(3,5-difluorophenyl)ethynyl)pyrimidine Drug Info [529531]
5-(2-(3-chlorophenyl)ethynyl)pyrimidine Drug Info [529531]
5-(2-(4-fluoro-3-methylphenyl)ethynyl)pyrimidine Drug Info [529531]
5-(2-m-tolylethynyl)pyrimidine Drug Info [529531]
5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile Drug Info [530843]
5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile Drug Info [530843]
5-(2-methylquinolin-7-yl)isophthalonitrile Drug Info [528922]
5-(2-methylquinolin-7-yl)nicotinonitrile Drug Info [528922]
5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine Drug Info [528893]
5-(phenylethynyl)pyrimidine Drug Info [529531]
5-Biphenyl-4-ylethynyl-pyrimidine Drug Info [529531]
5-Chloro-2-(2-methylquinolin-7-yl)benzonitrile Drug Info [530843]
5-methyl-3-phenylethynyl[1,2,4]triazine Drug Info [528893]
5-[(2-methyl-4-thiazolyl)ethynyl]pyrimidine Drug Info [528003]
6-(4-chlorophenylamino)-N,N-diethylnicotinamide Drug Info [530531]
6-bromo-N-(3-bromophenyl)quinazolin-4-amine Drug Info [530473]
6-bromo-N-(3-chlorophenyl)quinazolin-4-amine Drug Info [530473]
6-bromo-N-(3-fluorophenyl)quinazolin-4-amine Drug Info [530473]
6-bromo-N-m-tolylquinazolin-4-amine Drug Info [530473]
6-chloro-N-(3-chlorophenyl)quinazolin-4-amine Drug Info [530473]
6-fluoro-N-m-tolylquinazolin-4-amine Drug Info [530473]
6-phenylethynyl-nicotinic acid methyl ester Drug Info [529241]
7-(2-methoxyphenyl)-2-methylquinoline Drug Info [528922]
7-(3,5-dimethoxyphenyl)-1,6-naphthyridine Drug Info [529101]
7-(3-(methoxymethyl)phenyl)-2-methylquinoline Drug Info [528922]
7-(3-chlorophenyl)-2-methylquinoline Drug Info [528922]
7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine Drug Info [529101]
7-(3-fluorophenyl)-2-methylquinoline Drug Info [528922]
7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine Drug Info [529101]
7-(3-methoxyphenyl)-2-methylquinoline Drug Info [528922]
7-(4,6-dimethoxypyrimidin-2-yl)-2-methylquinoline Drug Info [528793]
7-(4,6-dimethylpyrimidin-2-yl)-2-methylquinoline Drug Info [528793]
7-(4-methoxyphenyl)-2-methylquinoline Drug Info [528922]
7-(4-methoxypyrimidin-2-yl)-2-methylquinoline Drug Info [528793]
7-bromo-N-(3-bromophenyl)isoquinolin-1-amine Drug Info [530473]
7-m-tolyl-1,6-naphthyridine Drug Info [529101]
7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine Drug Info [528998]
7-methyl-2-phenylpyrido[2,3-d]pyrimidine Drug Info [528998]
GLUTAMATE Drug Info [529001]
N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info [528212]
N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzamide Drug Info [528212]
N-(3-(3-cyanobenzamido)phenyl)-2-methoxybenzamide Drug Info [530486]
N-(3-acetamidophenyl)-3-chlorobenzamide Drug Info [530486]
N-(3-bromophenyl)-6-chloroquinazolin-4-amine Drug Info [530473]
N-(3-bromophenyl)-6-fluoroquinazolin-4-amine Drug Info [530473]
N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide Drug Info [531010]
N-(3-chlorophenyl)-6-fluoroquinazolin-4-amine Drug Info [530473]
N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine Drug Info [530473]
N-(3-chlorophenyl)-6-nitroquinazolin-4-amine Drug Info [530473]
N-(6-methylpyridin-2-yl)-5-phenylpicolinamide Drug Info [528711]
N-(6-methylpyridin-2-yl)-6-phenylnicotinamide Drug Info [530140]
N-(6-methylpyridin-2-yl)biphenyl-3-carboxamide Drug Info [530140]
N-cyclopentyl-6-(2-phenylethynyl)nicotinamide Drug Info [530138]
N-[4-(3-pyridylethynyl)-2-thiazolyl]acetamide Drug Info [528003]
QUISQUALATE Drug Info [534590]
SIB-1757 Drug Info [528186]
SIB-1893 Drug Info [528186]
Modulator (allosteric modulator) 3,3'-difluorobenzaldazine Drug Info [526693]
5-MPEP Drug Info [527733]
5PAM523 Drug Info [532177]
alloswitch-1 Drug Info [532936]
BOMA Drug Info [526911]
Br-5MPEPy Drug Info [527733]
CDPPB Drug Info [527282]
compound 10 Drug Info [527250]
compound 10 Drug Info [527251]
compound 11a Drug Info [526911]
compound 13 Drug Info [527417]
compound 16a Drug Info [526911]
compound 16m Drug Info [530531]
compound 18 Drug Info [528998]
compound 18 Drug Info [531628]
compound 20 Drug Info [527989]
compound 23 Drug Info [528922]
compound 24 Drug Info [532212]
compound 24d Drug Info [532205]
compound 26 Drug Info [527989]
compound 27 Drug Info [531010]
compound 29b Drug Info [531142]
compound 30 Drug Info [531559]
compound 36 Drug Info [529101]
compound 41 Drug Info [532244]
compound 42 Drug Info [528596]
compound 47 Drug Info [531355]
compound 53 Drug Info [532244]
compound 8 Drug Info [527251]
compound 8 Drug Info [531010]
CPPHA Drug Info [526946]
CPPZ Drug Info [531370]
LSN2463359 Drug Info [531998]
LSN2814617 Drug Info [531998]
M-5MPEP Drug Info [527733]
methoxymethyl-MTEP Drug Info [526461]
MPEP Drug Info [525618]
MTEB Drug Info [526911]
NCFP Drug Info [532201]
PTeB Drug Info [527190]
SP203 Drug Info [528895]
VU-1545 Drug Info [528212]
VU-29 Drug Info [528679]
VU0092273 Drug Info [531671]
VU0240382 Drug Info [531671]
VU0285683 Drug Info [531194]
VU0357121 Drug Info [531240]
VU0360172 Drug Info [531194]
VU0361747 Drug Info [531671]
VU0364289 Drug Info [532189]
VU0366058 Drug Info [531769]
VU0404251 Drug Info [532044]
VU0424465 Drug Info [532112]
VU0463841 Drug Info [532357]
[14C]MTEP Drug Info [526461]
[3H]CTEP Drug Info [531601]
[3H]fenobam Drug Info [527659]
[3H]M-MPEP Drug Info [526258]
[3H]methoxy-PEPy Drug Info [526531]
[3H]methoxymethyl-MTEP Drug Info [526531]
Modulator ADX-48621 Drug Info [550205]
ADX-63365 Drug Info [543750]
ADX10059 Drug Info [536890], [537360]
AFQ056 Drug Info [532401]
GRN-529 Drug Info [543750]
LY-3390334 Drug Info
McN3377 Drug Info [536166]
MK-3328 Drug Info [543750]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington&#039
s disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
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