Target Information

Target General Infomation
Target ID
T00239
Former ID
TTDR00086
Target Name
Interleukin-4
Gene Name
IL4
Synonyms
B-cell stimulatory factor 1; BSF-1; IL-4; Lymphocyte stimulatory factor 1; IL4
Target Type
Clinical Trial
Disease Allergy [ICD9: 995.3; ICD10: T78.4]
Asthma; Atopic eczema [ICD10: J45, L20-L30]
Asthma; Pulmonary tuberculosis [ICD10: J45, A15-A19]
Idiopathic pulmonary fibrosis [ICD9: 516.3; ICD10: J84.1]
Function
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
BioChemical Class
Growth factor
UniProt ID
P05112
Sequence
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Drugs and Mode of Action
Drug(s) IL-4R Drug Info Phase 2 Discovery agent [521488]
Pascolizumab Drug Info Phase 2 Asthma; Pulmonary tuberculosis [521497], [542738], [889377]
PEGylated pitrakinra Drug Info Phase 2 Asthma; Atopic eczema [889352], [889354]
SAR156597 Drug Info Phase 2 Idiopathic pulmonary fibrosis [889407]
SIL-4R Drug Info Discontinued in Phase 2 Discovery agent [545525]
PEGylated pitrakinra Drug Info Investigative Allergy [889443]
Inhibitor IL-4R Drug Info [535189]
SIL-4R Drug Info [537835]
Modulator Pascolizumab Drug Info [889443]
PEGylated pitrakinra Drug Info [889443]
SAR156597 Drug Info [889442]
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Leishmaniasis
Measles
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
NetPath Pathway TCR Signaling Pathway
TSLP Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database Notch signaling pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
WikiPathways Cytokines and Inflammatory Response
Inflammatory Response Pathway
IL-4 Signaling Pathway
Spinal Cord Injury
Allograft Rejection
Folate Metabolism
References
Ref 521488ClinicalTrials.gov (NCT00017693) Recombinant Human IL-4 Receptor Used in Treatment of Asthma. U.S. National Institutes of Health.
Ref 521497ClinicalTrials.gov (NCT00024544) Pilot Study in Patients With Symptomatic Steroid-Naive Asthma. U.S. National Institutes of Health.
Ref 542738(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7786).
Ref 545525Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003599)
Ref 889352ClinicalTrials.gov (NCT00676884) A Phase 2a Study to Investigate the Effects of Repeated Administration of AeroDerm in Subjects With Atopic Eczema
Ref 889354ClinicalTrials.gov (NCT00801853) A Study of the Treatment-Sparing Effects of AEROVANT?AER 001 Inhalation Powder in Asthma Patients, AEROTRIAL
Ref 889377ClinicalTrials.gov (NCT01638520) Safety and Efficacy of Blocking IL-4 With Pascolizumab in Patients Receiving Standard Therapy for Pulmonary Tuberculosis
Ref 889407ClinicalTrials.gov (NCT02345070) Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis
Ref 889443The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. doi: 10.1038/nrd3792.
Ref 535189Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001 Jun;107(6):963-70.
Ref 537835Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases. Behring Inst Mitt. 1995 Jun;(96):118-30.
Ref 889442Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. doi: 10.1038/nrd4478.
Ref 889443The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. doi: 10.1038/nrd3792.

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