Target Information

Target General Infomation
Target ID
T06182
Former ID
TTDI02208
Target Name
VIP 2 receptor
Gene Name
VIPR2
Synonyms
Helodermin-preferring VIP receptor; PACAP type III receptor; PACAP-R-3; PACAP-R3; Pituitary adenylate cyclase-activating polypeptide typeIII receptor; VIP-R-2; VPAC2; Vasoactive intestinal polypeptide receptor 2; VIPR2
Target Type
Clinical Trial
Disease Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10: J40-J44, J47]
Hypertension [ICD9: 401; ICD10: I10-I16]
Unspecified [ICD code not available]
Function
This is a receptor for VIP as well as PACAP-38 and -27,the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.
BioChemical Class
GPCR secretin
UniProt ID
P41587
Sequence
MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNIT
CWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKI
TFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKD
DVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRC
FLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFI
SIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFE
LCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQ
FHRGSRAQSFLQTETSVI
Drugs and Mode of Action
Drug(s) PB1046 Drug Info Phase 1 Hypertension [551504]
RG-7103 Drug Info Phase 1 Chronic obstructive pulmonary disease [522843]
Agonist helodermin Drug Info [534825]
PACAP-27 Drug Info [528390]
PB1046 Drug Info [550055]
RG-7103 Drug Info [548713]
Modulator PB-1120 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
Reactome G alpha (s) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class B Secretin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522843ClinicalTrials.gov (NCT01009424) A Multi-center Study to Investigate the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of R7103 Following Repeated Inhalation in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease. U.S. National Institutes of Health.
Ref 551504Clinical pipeline report, company report or official report of PhaseBio.
Ref 528390A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. Epub 2006 Aug 23.
Ref 534825Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52.
Ref 548713Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)
Ref 550055Clinical pipeline report, company report or official report of PhaseBio Pharmaceuticals.

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