Target Information

Target General Infomation
Target ID
T77473
Former ID
TTDI02369
Target Name
Translationally controlled tumor protein
Gene Name
TPT1
Synonyms
Fortilin; HRF; Histamine-releasing factor; TCTP; p23; TPT1
Target Type
Discontinued
Disease Acute myeloid leukemia [ICD9: 205; ICD10: C92.0]
Function
Involved in calcium binding and microtubule stabilization.
BioChemical Class
TCTP family
UniProt ID
P13693
Sequence
MIIYRDLISHDEMFSDIYKIREIADGLCLEVEGKMVSRTEGNIDDSLIGGNASAEGPEGE
GTESTVITGVDIVMNHHLQETSFTKEAYKKYIKDYMKSIKGKLEEQRPERVKPFMTGAAE
QIKHILANFKNYQFFIGENMNPDGMVALLDYREDGVTPYMIFFKDGLEMEKC
Drugs and Mode of Action
Drug(s) CER-227185 Drug Info Discontinued in Phase 1/2 Acute myeloid leukemia [548521]
Inhibitor CER-227185 Drug Info [550545]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
Pathway Interaction Database PLK1 signaling events
References
Ref 548521Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026293)
Ref 550545Clinical pipeline report, company report or official report of Cerep.

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