Target Information

Target General Infomation
Target ID
T86364
Former ID
TTDC00204
Target Name
Vasoactive intestinal polypeptide receptor 1
Gene Name
VIPR1
Synonyms
PACAP type II receptor; PACAP-R-2; Pituitary adenylate cyclase activating polypeptide type II receptor; VIP-R-1; VPAC-1; VPAC1; Vasoactive intestinal peptide receptor 1; Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor-1; VIPR1
Target Type
Clinical Trial
Disease Chronic obstructive pulmonary disease; Pulmonary arterial hypertension [ICD9: 401, 416.0, 490-492, 494-496; ICD10: I10-I16, I27.0, I27.2, J40-J44, J47]
Respiratory disease [ICD10: J00-J99]
Function
This is a receptor for vip. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is vip = pacap-27 > pacap-38.
BioChemical Class
GPCR secretin
Target Validation
T86364
UniProt ID
P32241
Sequence
MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENET
IGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPI
ACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMH
LFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYL
YTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGP
ILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFF
PDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRH
PSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
Structure
1OF2; 1OGT; 3B3I; 3B6S; 3DTX; 3HCV
Drugs and Mode of Action
Drug(s) Vasoactive intestinal peptide Drug Info Phase 2 Chronic obstructive pulmonary disease; Pulmonary arterial hypertension [522017]
Agonist helodermin Drug Info [534199]
PACAP-27 Drug Info [528390]
Modulator Respiratory disease therapeutics Drug Info [543801]
Antagonist Vasoactive intestinal peptide Drug Info [536294]
Inhibitor VIP Drug Info [529569]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
Pathway Interaction Database Glucocorticoid receptor regulatory network
Reactome G alpha (s) signalling events
WikiPathways SIDS Susceptibility Pathways
GPCRs, Class B Secretin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522017ClinicalTrials.gov (NCT00464932) Vasoactive Intestinal Peptide in COPD. U.S. National Institutes of Health.
Ref 528390A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. Epub 2006 Aug 23.
Ref 529569J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Ref 534199Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties. Eur J Pharmacol. 1996 Apr 29;302(1-3):207-14.
Ref 536294Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
Ref 543801(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 371).

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