Target Information

Target General Infomation
Target ID
T88505
Former ID
TTDNR00714
Target Name
Nuclear factor erythroid 2-related factor 2
Gene Name
NFE2L2
Synonyms
HEBP1; NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2; NFE2L2
Target Type
Clinical Trial
Disease Non-small cell lung cancer [ICD10: C33-C34]
Ocular inflammation [ICD9: 370.33; ICD10: H16.229]
Function
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
BioChemical Class
bZIP Maf transcription factor
UniProt ID
Q16236
Sequence
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
Drugs and Mode of Action
Drug(s) ABT-RTA-408 Drug Info Phase 2 Non-small cell lung cancer [524762]
OT-551 Drug Info Phase 2 Ocular inflammation [521815]
Modulator ABT-RTA-408 Drug Info [550508]
Inhibitor OT-551 Drug Info [532414]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Protein processing in endoplasmic reticulum
NetPath Pathway IL5 Signaling Pathway
WikiPathways Oxidative Stress
Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
Aryl Hydrocarbon Receptor Pathway
Mesodermal Commitment Pathway
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Arylhydrocarbon receptor (AhR) signaling pathway
References
Ref 521815ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health.
Ref 524762ClinicalTrials.gov (NCT02142959) RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE. U.S. National Institutes of Health.
Ref 532414New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2.
Ref 550508National Cancer Institute Drug Dictionary (drug id 756624).

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