Target Information

Target General Infomation
Target ID
T90828
Target Name
Interleukin-5 receptor subunit alpha
Gene Name
IL5RA
Synonyms
IL5RA
Target Type
Clinical Trial
Disease Asthma; Chronic obstructive pulmonary disease; Hypereosinophilic syndrome; asthma; Eosinophilic chronic rhinosinusitis [ICD10: D72.1, J40-J44, J45]
Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10: J40-J44, J47, J45]
Function
This is the receptor for interleukin-5. The alpha chain binds to IL5.
UniProt ID
Q01344
Sequence
MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRN
VNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHA
PPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTE
ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQIN
PPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDD
LSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFVIVIMATICFILLILSL
ICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF
Drugs and Mode of Action
Drug(s) Benralizumab Drug Info Phase 3 Asthma; Chronic obstructive pulmonary disease [525153], [542653]
Benralizumab Drug Info Phase 1/2 Asthma; Chronic obstructive pulmonary disease; Hypereosinophilic syndrome; asthma; Eosinophilic chronic rhinosinusitis [889397], [889422], [889428], [889429]
Modulator Benralizumab Drug Info [889445]
References
Ref 525153ClinicalTrials.gov (NCT02417961) Study to Assess Functionality, Reliability, and Performance of a Pre-filled Syringe With Benralizumab Administered at Home. U.S. National Institutes of Health.
Ref 542653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7674).
Ref 889397ClinicalTrials.gov (NCT02130882) Study to Evaluate Safety and Efficacy of Benralizumab in Subjects With Hypereosinophilic Syndrome
Ref 889422ClinicalTrials.gov (NCT02772419) Study of Benralizumab (KHK4563) in Patients With Eosinophilic Chronic Rhinosinusitis
Ref 889428ClinicalTrials.gov (NCT02968914) Pharmacokinetic Comparability of Benralizumab Using Accessorized Pre-Filled Syringe or Autoinjector in Healthy Volunteers
Ref 889429ClinicalTrials.gov (NCT03010436) Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study
Ref 889445Benralizumab--a humanized mAb to IL-5R with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma. Expert Opin Biol Ther. 2012 Jan;12(1):113-8. doi: 10.1517/14712598.2012.642359. Epub 2011 Dec 5.

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