Resistance mutation info of target

Target General Information
Target ID T52617
Target Name Bacterial 3-oxoacyl-[acyl-carrier-protein] synthase 1 (kasA) Target Info
Gene Name kasA
Species Mycobacterium tuberculosis
Uniprot ID FAB1_MYCTU
Sequence MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE
RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH
AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL
SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL
TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY [My
cobacterium tuberculosis]
Drug Resistance Mutation and Corresponding Drugs
Ref 536472Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
Mutation Info Missense: D66N
Drugs
Drug Name Isoniazid Drug Info [556217], [556238]
Targeted Disease Tuberculosis
Mutation Info Missense: F413L
Drugs
Drug Name Isoniazid Drug Info [556217], [556238]
Targeted Disease Tuberculosis
Mutation Info Missense: G269S
Drugs
Drug Name Isoniazid Drug Info [556217], [556238]
Targeted Disease Tuberculosis
Mutation Info Missense: G312S
Drugs
Drug Name Isoniazid Drug Info [556217], [556238]
Targeted Disease Tuberculosis
Mutation Info Missense: G387D
Drugs
Drug Name Isoniazid Drug Info [555454], [556238]
Targeted Disease Tuberculosis
Mutation Info Missense: M77I
Drugs
Drug Name Isoniazid Drug Info [555514]
Targeted Disease Tuberculosis
Mutation Info Missense: R121K
Drugs
Drug Name Isoniazid Drug Info [555454], [556243]
Targeted Disease Tuberculosis
Reference
Ref 555454Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore. Antimicrob Agents Chemother. 1999 Aug;43(8):2087-9.
Ref 555514Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2003 Apr;47(4):1241-50.
Ref 556238Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Curr Opin Microbiol. 2015 Oct;27:45-50. doi: 10.1016/j.mib.2015.07.004. Epub 2015 Jul 31.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 556217Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. Science. 1998 Jun 5;280(5369):1607-10.

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