TTD - Therapeutic Targets Databse Version 4.3.02 (2011.08.25) File Name: List of 119 nature nature-derived preclinical drugs and their species origins. Following the seminal works of Newman and Cragg (J Nat Prod. 2007 Mar;70(3):461-77), the drug types are defined as follows: "B" Biological, a peptide or protein either isolated from an organism/cell line or produced by biotechnological means in a surrogate host; "N" Natural product; "ND" Derived from a natural product and is usually a semisynthetic modification; "NM" Natural product mimic; "S*" Made by total synthesis based on the pharmacophore from a natural product; "V" Vaccine. Reference: Zhu F, Qin C, Tao L, Liu X, Shi Z, Ma X, Jia J, Tan Y, Cui C, Lin J, Tan C, Jiang Y, Chen Y. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc Natl Acad Sci U S A (PNAS). 2011 Aug 2;108(31):12943-8. Drug name Relationship to natural product Species origin (family) Therapeutic class or targeted disease A54556 A/B Depsipeptide Streptomyces hawaiiensis (Streptomycetaceae) Antibacterial AB-5 Semi-synthetic derivative of Diazonamide Phlebobranchia (Phlebobranchia) Anticancer Abyssomicin Natural product Verrucosispora (Micromonosporaceae) Antibacterial AC98-6446 Semi-synthetic derivative of Mannopeptimycin Streptomyces hygroscopicus (Streptomycetaceae) Antibacterial ACV1 Natural product Conus victoriae (Conidae) Pain ADEP 2 Semi-synthetic derivative of acyldepsipeptidolactones Streptomyces hawaiiensis (Streptomycetaceae) Antibacterial Alpha-Conotoxin Vc1.1 Natural product Conus victoriae (Conidae) Neuropathic Pain Alpha-TOS Natural product Homo sapiens (Hominidae) Cancer AMM336 Natural product Conus catus (Conidae) Pain Anti-hepcidin antibody Antibody Homo sapiens (Hominidae) Anti-inflammatory Aplyronine A A potent antitumor substance isolated from the sea hare, natural product Aplysia kurodai (Aplysiidae) Oncological disease Artelinic acid Semi-synthetic derivative of artemisinin Artemisia annua (Asteraceae) Antimalarial Arylomycin Natural product Streptomyces (Streptomycetaceae) Antibacterial Ascididemin An aromatic alkaloid, natural product Didemnum sp. (Didemnidae) Oncological disease Ascididemin An aromatic alkaloid, natural product Cystodytes dellechiajei (Polycitoridae) Oncological disease Ascididemnin A marine alkaloid Cystodytes dellechiajei (Polycitoridae) Oncological disease Asperlicin Natural product Aspergillus alliaceus (Trichocomaceae) Anticancer Avarol Natural product Dysidea avara (Dysideidae) Anti-HIV Beta-4-amino etoposide analog Semi-synthetic derivative of podophyllotoxin Podophyllum peltatum (Berberidaceae) Anticancer Betulinic acid Natural product Betula pubescens (Betulaceae) Cancer BMS-185660 Semi-synthetic derivative of Taxol Seimatoantlerium tepuiense (Amphisphaeriaceae) Anticancer BMS-185660 Semi-synthetic derivative of Taxol Corylus avellana (Betulaceae) Anticancer BMS-185660 Semi-synthetic derivative of Taxol Taxus wallichiana (Taxaceae) Anticancer BMS-185660 Semi-synthetic derivative of Taxol Taxus brevifolia (Taxaceae) Anticancer BMS-185660 Semi-synthetic derivative of Taxol Taxus baccata (Taxaceae) Anticancer BMS-249524 Natural product Nocardia (Nocardiaceae) Antibacterial BMS-411886 Semi-synthetic derivative of nocathiacin I Nocardia (Nocardiaceae) Antibacterial BMS-461996 Semi-synthetic derivative of nocathiacin I Nocardia (Nocardiaceae) Antibacterial Calanolide B A natural product Calophyllum (Calophyllaceae) Antiviral Calcitonin gene-related peptide Peptide Homo sapiens (Hominidae) Anti-mirraine Cethromycin Semi-synthetic derivative of Erythromycin A Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial CGX-1007 Natural product Conus geographus (Conidae) Epilepsy CGX-1063 A modified toxin Conus geographus (Conidae) Neurological disease CGX-1160 Natural product Conus geographus (Conidae) Pain CHAP31 Peptidomimetic of trapoxin peptide Helicoma ambiens (Tubeufiaceae) Anticancer Chi-conopeptides Natural product Conus marmoreus (Conidae) Neuropathic Pain Chi-conotoxin A molecule isolated from Conus sp. Conus marmoreus (Conidae) Neurological disease Clindamycin Semi-synthetic derivative of lincomycin Streptomyces lincolnensis (Streptomycetaceae) Antibacterial Combretastatin A4 Natural product Combretum caffrum (Combretaceae) Anticancer Conantokin-G A nurotoxin from Conus geographus Conus geographus (Conidae) epilepsy Contignasterol Natural product Petrosia (Petrosiidae) anti-asthma Coversin Peptide Ixodoidea (Ixodoidea) Asthma Cryptophycin-249 Semi-synthetic derivative of Taxol Seimatoantlerium tepuiense (Amphisphaeriaceae) Oncological disease Cryptophycin-249 Semi-synthetic derivative of Taxol Corylus avellana (Betulaceae) Oncological disease Cryptophycin-249 Semi-synthetic derivative of Taxol Taxus wallichiana (Taxaceae) Oncological disease Cryptophycin-249 Semi-synthetic derivative of Taxol Taxus brevifolia (Taxaceae) Oncological disease Cryptophycin-249 Semi-synthetic derivative of Taxol Taxus baccata (Taxaceae) Oncological disease Cryptophycin-309 Semi-synthetic derivative of Taxol Seimatoantlerium tepuiense (Amphisphaeriaceae) Oncological disease Cryptophycin-309 Semi-synthetic derivative of Taxol Corylus avellana (Betulaceae) Oncological disease Cryptophycin-309 Semi-synthetic derivative of Taxol Taxus wallichiana (Taxaceae) Oncological disease Cryptophycin-309 Semi-synthetic derivative of Taxol Taxus brevifolia (Taxaceae) Oncological disease Cryptophycin-309 Semi-synthetic derivative of Taxol Taxus baccata (Taxaceae) Oncological disease Curacin A A thiazole lipid, natural product Lyngbya majuscula (Lyngbya) Oncological disease Cyanidin-3-Glucoside Natural product Allium cepa (Amaryllidaceae) Anti-obesity Cyanidin-3-Glucoside Natural product Brassica oleracea (Brassicaceae) Anti-obesity Cyanidin-3-Glucoside Natural product Vaccinium vitis-idaea (Ericaceae) Anti-obesity Cyanidin-3-Glucoside Natural product Malus x domestica (Rosaceae) Anti-obesity Cyanidin-3-Glucoside Natural product Prunus (Rosaceae) Anti-obesity Cyanovirin N Protein Nostoc ellipsosporum (Nostocaceae) Antiviral Cyclostreptin Natural product Streptomyces (Streptomycetaceae) Oncological disease Dalbavancin Peptidomimetic Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial DCK Semi-synthetic derivative of suksdorfin Lomatium (Apiaceae) Antiviral DCQA Natural product Xanthium strumarium (Asteraceae) Antiviral DCQA Natural product Chrysanthemum (Asteraceae) Antiviral DCQA Natural product Doellingeria scabra (Asteraceae) Antiviral DCQA Natural product Dittrichia viscosa (Asteraceae) Antiviral DCQA Natural product Pyrus (Rosaceae) Antiviral Diazonamide A cyclic peptide, natural product Phlebobranchia (Phlebobranchia) Oncological disease Dictyodendrins A pyrrolocarbazole derivatives, natural product Dictyodendrillidae (Dictyodendrillidae) Oncological disease Dictyostatin-1 Natural product Spongia (Spongiidae) Anticancer DMMC Cyclic peptide Lyngbya majuscula (Lyngbya) Anticancer Dolastatin 15 Natural product Dolabella auricularia (Aplysiidae) Cancer ECO-0501 Natural product Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial Eleutherobin A diterpene glycoside, natural product Eleutherobia (Alcyoniidae) Oncological disease Eleutherobin A diterpene glycoside, natural product Eleutherobia (Alcyoniidae) Oncological disease Eleutherobin A diterpene glycoside, natural product Erythropodium caribaeorum (Anthothelidae) Oncological disease EP-013420 Semi-synthetic derivative of Erythromycin A Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial ER-076349 Semi-synthetic derivative of halichondrin B Axinella (Axinellidae) Oncological disease ER-076349 Semi-synthetic derivative of halichondrin B Phakellia (Axinellidae) Oncological disease ER-076349 Semi-synthetic derivative of halichondrin B Lissodendoryx (Coelosphaeridae) Oncological disease ER-076349 Semi-synthetic derivative of halichondrin B Halichondria okadai (Halichondriidae) Oncological disease ER-086527 Semi-synthetic derivative of halichondrin B Axinella (Axinellidae) Oncological disease ER-086527 Semi-synthetic derivative of halichondrin B Phakellia (Axinellidae) Oncological disease ER-086527 Semi-synthetic derivative of halichondrin B Lissodendoryx (Coelosphaeridae) Oncological disease ER-086527 Semi-synthetic derivative of halichondrin B Halichondria okadai (Halichondriidae) Oncological disease ES-285 Natural product Mactromeris polynyma (Mactridae) Cancer FR182876 Natural product Streptomyces (Streptomycetaceae) Oncological disease FR290581 Semi-synthetic derivative of Zofimarin Zopfiella marina (Chaetomiaceae) Antifungal FR290581 Semi-synthetic derivative of Zofimarin Zopfiella marina (Chaetomiaceae) Antifungal GE23077 Cyclic peptide Actinomadura (Thermomonosporaceae) Antibacterial GE81112 Peptide Streptomyces (Streptomycetaceae) Antibacterial GM237354 Semi-synthetic derivative of sordarin Sordaria araneosa (Sordariaceae) Antifungal GR-71251 Peptidomimetic of substance P Homo sapiens (Hominidae) Antidepressant GS-8374 Semi-synthetic derivative of pepstatin Actinomyces (Actinomycetaceae) Anti-HIV Halichondrin B Natural product Halichondria okadai (Halichondriidae) Anticancer Halimide Natural product Aspergillus (Trichocomaceae) Anticancer HMDCK Molecule modified from suksdorfin Lomatium (Apiaceae) Antiviral IC9564 Semi-synthetic derivative of betulinic acid Syzygium claviflorum (Myrtaceae) Antiviral IDN 5390 Semi-synthetic derivative of Paclitaxel Seimatoantlerium tepuiense (Amphisphaeriaceae) Oncological disease IDN 5390 Semi-synthetic derivative of Paclitaxel Corylus avellana (Betulaceae) Oncological disease IDN 5390 Semi-synthetic derivative of Paclitaxel Taxus wallichiana (Taxaceae) Oncological disease IDN 5390 Semi-synthetic derivative of Paclitaxel Taxus brevifolia (Taxaceae) Oncological disease IDN 5390 Semi-synthetic derivative of Paclitaxel Taxus baccata (Taxaceae) Oncological disease IPL512602 Semi-synthetic derivative of steroid contignasterol Petrosia (Petrosiidae) Antiinflammatory Jatrophane 1 Natural product Euphorbia (Euphorbiaceae) Anticancer JE-2147 Semi-synthetic derivative of pepstatin, Peptidomimetic of Phe-Pro sequence Actinomyces (Actinomycetaceae) Anti-HIV KB141 Mimetics of thyroid hormone Homo sapiens (Hominidae) Atherosclerosis KF58333 Semi-synthetic derivative of radicicol Scedosporium (Microascaceae) Anticancer L-783,281 Natural product Pseudomassaria (Hyponectriaceae) Anti-diabetes L868276 Semi-synthetic derivative of rohitukine Meliaceae (Meliaceae) Oncological disease L868276 Semi-synthetic derivative of rohitukine Dysoxylum (Meliaceae) Oncological disease Lamellarin D A pyrrole alkaloid, natural product Lamellaria (Lamellariidae) Oncological disease Laulimalide A macrocyclic lactone, a macrolide, natural product Cacospongia (Thorectidae) Oncological disease LY294002 Semi-synthetic derivative of quercetin Cuscuta australis (Convolvulaceae) Oncological disease LY294002 Semi-synthetic derivative of quercetin Cuscuta chinensis (Convolvulaceae) Oncological disease LY294002 Semi-synthetic derivative of quercetin Camellia sinensis (Theaceae) Oncological disease LY-333328 Peptidomimetic Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial MrIA/B A nurotoxin from Conus marmoreus Conus marmoreus (Conidae) neuropathic pain Muraymycin Natural product Streptomyces (Streptomycetaceae) Antibacterial NAI-107 Natural product Microbispora (Streptosporangiaceae) Antibacterial Neoamphimedine A pyridoacridine alkaloid from Xestospongia sp. Xestospongia (Petrosiidae) Oncological disease NPI-3114 Natural product Actinomyces (Actinomycetaceae) Antibiotic NPI-3304 Natural product Actinomyces (Actinomycetaceae) Antibiotic NVB302 Semi-synthetic derivative of deoxyactagardine Actinoplanes liguriensis (Micromonosporaceae) Antibacterial Peloruside A A macrocyclic lactone, natural product Mycale (Mycalidae) Oncological disease Pervilleine A Natural product Erythroxylum (Erythroxylaceae) Cancer Pirlimycin Semi-synthetic derivative of lincomycin Streptomyces lincolnensis (Streptomycetaceae) Antibacterial Platensimycin Natural product Streptomyces platensis (Streptomycetaceae) Antibacterial PM01218 Natural product Hymedesmiidae (Hymedesmiidae) Anticancer Protoapigenone analog Semi-synthetic derivative of Protoapigenone Thelypteris torresiana (Thelypteridaceae) Anticancer R-135853 Semi-synthetic derivative of Zofimarin Zopfiella marina (Chaetomiaceae) Antifungal R-135853 Semi-synthetic derivative of Zofimarin Zopfiella marina (Chaetomiaceae) Antifungal Rho-Conotoxin TIA A reversible noncompetitive inhibitor of ¦Á-1 adrenergic receptors Conus tulipa (Conidae) Neurological disease Robotnikinin Semi-synthetic derivative of macrolactones Nocardiopsis (Nocardiopsaceae) Anticancer RPR103611 Semi-synthetic derivative of Betulinic acid Syzygium claviflorum (Myrtaceae) Antiviral RU-64004 Semi-synthetic derivative of Erythromycin A Saccharopolyspora erythraea (Pseudonocardiaceae) Antibacterial Sagopilone Semi-synthetic derivative of epothilone B Sorangium cellulosum (Polyangiaceae) Anticancer Salicylihalimide A A salicylate macrolide and a polyketide, natural product Haliclona sp. (Chalinidae) Oncological disease Salicylihalimide B A salicylate macrolide and a polyketide, natural product Haliclona sp. (Chalinidae) Oncological disease Salinosporamide A Natural product Salinispora (Micromonosporaceae) Cancer Sarcodictyin A A diterpene, natural product Clavulariidae (Clavulariidae) Oncological disease Sarcodictyin B A diterpene, natural product Clavulariidae (Clavulariidae) Oncological disease SCH-725424 Natural product Kitasatospora (Streptomycetaceae) Antibacterial Silvestrol A natural product Aglaia silvestris (Meliaceae) Oncological disease SNX-325 Natural product Segestria florentina (Segestriidae) Pain TAN-1057A/B Natural product Flexibacter (Cytophagaceae) Antibacterial Telavancin Peptidomimetic Amycolatopsis orientalis (Pseudonocardiaceae) Antibacterial Thiocoraline A depsipeptide, natural product Micromonospora marina (Micromonosporaceae) Oncological disease TI-356 Semi-synthetic derivative of RA-VII Rubia (Rubiaceae) Oncological disease TI-356 Semi-synthetic derivative of RA-VII Rubia cordifolia (Rubiaceae) Oncological disease TM-701 Peptide Leiurus quinquestriatus (Buthidae) Anticancer TMC-95-A Cyclic peptide Apiospora montagnei (Apiosporaceae) Anticancer Variolin B A heterocyclic alkaloid, natural product Hymedesmiidae (Hymedesmiidae) Oncological disease VIC-105555 Semi-synthetic derivative of lincomycin Streptomyces lincolnensis (Streptomycetaceae) Antibacterial VIC-5555 Semi-synthetic derivative of lincomycin Streptomyces lincolnensis (Streptomycetaceae) Antibiotic Vitilevuamide A cyclic peptide, natural product Didemnum (Didemnidae) Oncological disease Vitilevuamide A cyclic peptide, natural product Polysyncraton (Didemnidae) Oncological disease XEP-018 Peptide Conus (Conidae) Neurological disease YM753 Cyclic-peptide Pseudomonas (Pseudomonadaceae) Oncological disease