Drug General Information
Drug ID
D0A5BT
Drug Name
Camostat mesylate
Synonyms
Camostat (mesylate); Camostat Methanesulfonate; Camostat methanesulfate; DSSTox_CID_238; DSSTox_GSID_20238; DSSTox_RID_75452; FOY 305; FOY-305; FOY305; Foipan; Foipan (TN); Foipan mesylate; NCGC00167526-01; Q-200778; UNII-451M50A1EQ; camostat mesilate; 451M50A1EQ; C21H26N4O8S; CAS-59721-29-8; CHEMBL85164
Drug Type
Small molecular drug
Indication Coronavirus Disease 2019 (COVID-19) Phase 2 [1], [2]
Middle East Respiratory Syndrome (MERS) Investigative [3]
Severe acute respiratory syndrome (SARS) Investigative [3]
Therapeutic Class
Antiviral Agents
Structure
Download
2D MOL

3D MOL

Formula
C21H26N4O8S
Canonical SMILES
CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O
InChI
1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChIKey
FSEKIHNIDBATFG-UHFFFAOYSA-N
CAS Number
CAS 59721-29-8
PubChem Compound ID
Target
Target(s) HUMAN transmembrane protease serine 2 (TMPRSS2) Target Info Inhibitor [1], [3]
Camostat mesylate inhibits MERS-CoV, SARS-CoV and SARS-CoV-2 in vitro via inhibiting TMPRSS2 which is a serine protease that mediates the cell surface entry pathway.
References
1 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr 16;181(2):271-280.e8.
2 ClinicalTrials.gov (NCT04353284) Camostat Mesylate in COVID-19 Outpatients
3 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.

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