Drug General Information
Drug ID
D07BYK
Former ID
DAP000488
Drug Name
Penciclovir
Synonyms
penciclovir; 39809-25-1; Denavir; Penciclovirum; Vectavir; Penciclovirum [INN-Latin]; Pencyclovir; BRL-39123; BRL 39123; Penciclovir [USAN:INN:BAN]; Penciceovir; UNII-359HUE8FJC; CCRIS 9213; PE2
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] Approved [1], [2]
Discovery agent [ICD-11: N.A.] Investigative [3]
Therapeutic Class
Antiviral Agents
Structure
Download
2D MOL

3D MOL

Formula
C10H15N5O3
Canonical SMILES
C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N
InChI
1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
InChIKey
JNTOCHDNEULJHD-UHFFFAOYSA-N
CAS Number
CAS 39809-25-1
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
D06BB06; J05AB13
SuperDrug CAS ID
cas=039809251
Target and Pathway
Target(s) Herpes simplex virus DNA polymerase UL30 (HSV UL30) Target Info Inhibitor [4]
Thymidine kinase 1 (TK1) Target Info Inhibitor [3]
References
REF 1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
REF 2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
REF 3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
REF 4 Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.

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