Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07PBZ
|
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| Former ID |
DAP000202
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| Drug Name |
Epoetin alfa
|
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| Synonyms |
Epogen (TN); Procrit (TN)
|
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| Indication | Anemia [ICD-11: 3A00-3A9Z; ICD-9: 280-285] | Approved | [1] | ||
| Therapeutic Class |
Antianemic Agents
|
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| Company |
Amgen Inc
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| Formula |
C815H1317N233O241S5
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| CAS Number |
CAS 113427-24-0
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| SuperDrug ATC ID |
B03XA01
|
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| Target and Pathway | |||||
| Target(s) | Erythropoietin Receptor (EPOR) | Target Info | Agonist | [2], [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | |||||
| Jak-STAT signaling pathway | |||||
| Hematopoietic cell lineage | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by Stem cell factor receptor (c-Kit) | ||||
| EPO signaling pathway | |||||
| WikiPathways | EPO Receptor Signaling | ||||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 103951. | ||||
| REF 2 | 2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer. PediatrBlood Cancer. 2009 Jul;53(1):7-12. | ||||
| REF 3 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | ||||
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