Drug General Information
Drug ID
D07PBZ
Former ID
DAP000202
Drug Name
Epoetin alfa
Synonyms
Epogen (TN); Procrit (TN)
Indication Anemia [ICD-11: 3A00-3A9Z; ICD-9: 280-285] Approved [1]
Therapeutic Class
Antianemic Agents
Company
Amgen Inc
Formula
C815H1317N233O241S5
CAS Number
CAS 113427-24-0
SuperDrug ATC ID
B03XA01
Target and Pathway
Target(s) Erythropoietin Receptor (EPOR) Target Info Agonist [2], [3]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
WikiPathways EPO Receptor Signaling
References
REF 1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 103951.
REF 2 2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer. PediatrBlood Cancer. 2009 Jul;53(1):7-12.
REF 3 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.

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