Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T57387 Target Info
Target Name Geminin (GMNN)
Synonyms geminin DNA replication inhibitor; MGORS6
Target Type Literature-reported Target
Gene Name GMNN
UniProt ID
O75496
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-449a miRNA Info
miRNA Mature AC
MIMAT0001541
Sequence uggcaguguauuguuagcuggu
miRNA Species Homo sapiens
Regulation Mechanism Direct interaction of miR-449 with the target gene GMMN 3'UTR was confirmed. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Cyclin-dependent kinase 4 (CDK4) Target Info
CDK4_HUMAN
miRNA Mature ID hsa-miR-449b-5p miRNA Info
miRNA Mature AC
MIMAT0003327
Sequence aggcaguguauuguuagcuggc
miRNA Species Homo sapiens
Regulation Mechanism Direct interaction of miR-449 with the target gene GMMN 3'UTR was confirmed. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA Cyclin-dependent kinase 4 (CDK4) Target Info
CDK4_HUMAN
Cyclin-dependent kinase 6 (CDK6) Target Info
CDK6_HUMAN
References  Top
REF 1 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer. 2011 Mar 18;10:29.

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