Target General Information
Target ID	T88240
Target Name	Bacterial Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (DHPS)
Gene Name	folP
Species	Escherichia coli
UniProt ID	DHPS_ECOLI
Sequence	MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE [Escherichia coli ]
Drug and Corresponding Resistance Mutations
Mutation Info	Missense: A587V
Drugs	Drug Name Sulfadiazine Drug Info [2] Targeted Disease Toxoplasmosis
Mutation Info	Missense: F25I
Drugs	Drug Name Sulfonamide Drug Info [4]
Mutation Info	Missense: K540E
Drugs	Drug Name Sulfamethoxazole Drug Info [1] Targeted Disease Plasmodium Falciparum Malaria
Mutation Info	Missense: K540N
Drugs	Drug Name Sulfamethoxazole Drug Info [1] Targeted Disease Plasmodium Falciparum Malaria
Mutation Info	Missense: P55A
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P55H
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P55L
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P55R
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P55S
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P55T
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: P64A
Drugs	Drug Name Sulfonamide Drug Info [3]
Mutation Info	Missense: P64H
Drugs	Drug Name Sulfonamide Drug Info [3]
Mutation Info	Missense: P64L
Drugs	Drug Name Sulfonamide Drug Info [3]
Mutation Info	Missense: P64R
Drugs	Drug Name Sulfonamide Drug Info [3]
Mutation Info	Missense: P64S
Drugs	Drug Name Sulfonamide Drug Info [3]
Mutation Info	Missense: T53A
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: T53I
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: T53N
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
Mutation Info	Missense: T53P
Drugs	Drug Name Dapsone Drug Info [3] Targeted Disease Hansen disease
References
REF 1	Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation. Antimicrob Agents Chemother. 2011 May;55(5):2481-2.
REF 2	In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Antimicrob Agents Chemother. 2008 Apr;52(4):1269-77.
REF 3	CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 4	The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.