Drug Information

Drug General Information
Drug ID
D01ENR
Former ID
DNC005184
Drug Name
4-[2-(2-Benzyl-phenoxy)-ethyl]-morpholine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527160]
Structure
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2D MOL

3D MOL
Formula
C19H23NO2
Canonical SMILES
C1COCCN1CCOC2=CC=CC=C2CC3=CC=CC=C3
InChI
1S/C19H23NO2/c1-2-6-17(7-3-1)16-18-8-4-5-9-19(18)22-15-12-20-10-13-21-14-11-20/h1-9H,10-16H2
InChIKey
DQESEABEPUDVEZ-UHFFFAOYSA-N
PubChem Compound ID
2993172
Target and Pathway
Target(s) D(1B) dopamine receptor Target Info Inhibitor [527160]
D(4) dopamine receptor Target Info Inhibitor [527160]
Dopamine D1 receptor Target Info Inhibitor [527160]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
References
Ref 527160J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.
Ref 527160J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.

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