Drug Information

Drug General Information
Drug ID
D04PXS
Former ID
DNCL003085
Drug Name
Amitifadine
Synonyms
EB-1010
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 3 [527289], [528424]
Company
Euthymics Bioscience
Structure
Download
2D MOL

3D MOL
Formula
C11H11Cl2N
Canonical SMILES
C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
InChI
1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2/t8-,11+/m1/s1
InChIKey
BSMNRYCSBFHEMQ-KCJUWKMLSA-N
CAS Number
CAS 410074-73-6
PubChem Compound ID
11658655
PubChem Substance ID
16762225, 23759405, 79665353, 103722192, 134339263, 134339265, 135268704, 135626807, 137228329, 141074206, 160865895, 162527019, 163640642, 172912822, 198946104, 198962154, 202535634, 223519165, 224200675, 226709517, 242791435
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [543976]
Sodium-dependent dopamine transporter Target Info Inhibitor [543975]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [543974]
KEGG Pathway Serotonergic synapsehsa04728:Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 527289J Clin Pharmacol. 2004 Dec;44(12):1360-7.DOV 216,303, a "triple" reuptake inhibitor: safety, tolerability, and pharmacokinetic profile.
Ref 528424Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34.
Ref 543974(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926).
Ref 543975(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).
Ref 543976(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 928).

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