Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05LAR
|
||||
| Former ID |
DNC000125
|
||||
| Drug Name |
A77-1726 (monosodium salt)
|
||||
| Drug Type |
Small molecular drug
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C12H9F3N2O2
|
||||
| Canonical SMILES |
CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
|
||||
| InChI |
1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
|
||||
| InChIKey |
UTNUDOFZCWSZMS-YFHOEESVSA-N
|
||||
| CAS Number |
CAS 108605-62-5
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
605680, 836841, 8020778, 12014666, 15221873, 17182873, 29223012, 32961983, 36887811, 39470329, 49896832, 53790606, 57363933, 77206778, 77206779, 77206780, 93311044, 99311205, 103252419, 103929187, 104304838, 104633246, 113986292, 131294182, 134223898, 134338701, 134338970, 134340294, 134340452, 135074184, 135263629, 135626890, 137116564, 143267135, 152134192, 160645856, 162254943, 163414519, 163620868, 163686197, 164178177, 164835947, 172919649, 175266318, 176251501, 178103450, 180100588, 180371831, 187072836, 198993049
|
||||
| Target and Pathway | |||||
| Target(s) | Dihydroorotate dehydrogenase, mitochondrial | Target Info | Inhibitor | [535028], [538136] | |
| KEGG Pathway | Pyrimidine metabolism | ||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Pyrimidine Metabolism | ||||
| Reactome | Pyrimidine biosynthesis | ||||
| WikiPathways | Metabolism of nucleotides | ||||
| References | |||||
| Ref 535028 | Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8. | ||||
| Ref 538136 | Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. Biochem Pharmacol. 1998 Nov 1;56(9):1259-64. | ||||
| Ref 535028 | Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8. | ||||
| Ref 538136 | Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives. Biochem Pharmacol. 1998 Nov 1;56(9):1259-64. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.