Drug Information

Drug General Information
Drug ID
D08NJF
Former ID
DCL000948
Drug Name
Radaxafine HCl
Drug Type
Small molecular drug
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Discontinued in Phase 1 [536374]
Therapeutic Class
Analgesics
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C21H26Cl2N2O4
Canonical SMILES
C1CCC2(C1)CCN(CC2)C(=O)C(CCC(=O)O)NC(=O)C3=CC(=CC(=C3)C<br />l)Cl
InChI
1S/C21H26Cl2N2O4/c22-15-11-14(12-16(23)13-15)19(28)24-17(3-4-18(26)27)20(29)25-9-7-21(8-10-25)5-1-2-6-21/h11-13,17H,1-10H2,(H,24,28)(H,26,27)/t17-/m1/s1
InChIKey
FJCZHMXAGBYXHJ-QGZVFWFLSA-N
CAS Number
CAS 106083-71-0
PubChem Compound ID
65987
PubChem Substance ID
8190084, 14759366, 43122711, 51879128, 57315875, 103204463, 103979153, 104335186, 117460911, 127854762, 134339387, 134340554, 135023674, 162475666, 179149886, 198968017, 225056605, 233479949
Target and Pathway
Target(s) Dopamine reuptake Target Info Inhibitor [536374]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536374]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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