Drug Information

Drug General Information
Drug ID
D0B0TK
Former ID
DIB018976
Drug Name
bilobalide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539505]
Structure
Download
2D MOL
Formula
C15H18O8
InChI
InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
InChIKey
MOLPUWBMSBJXER-YDGSQGCISA-N
PubChem Compound ID
73581
PubChem Substance ID
612782, 8195779, 16291978, 22401403, 26754286, 26754287, 43129494, 48483982, 50066930, 50356007, 57319167, 72294694, 85756505, 92465249, 99319068, 103068082, 103083126, 104355597, 119525292, 124558739, 124791097, 135652670, 136198417, 137140610, 141417239, 162187986, 162220494, 163614295, 175607715, 179326410, 184546819, 184812239, 198968270, 204379274, 210280216, 210282195, 223567071, 223668098, 223701049, 226629534, 241062586, 241201449, 242132532, 249865353, 252063817, 252216667, 252345969
Target and Pathway
Target(s) 5-HT3AB Target Info Blocker (channel blocker) [531254]
5-hydroxytryptamine receptor 3A Target Info Blocker (channel blocker) [531440]
Glycine Receptor (All subtypes) Target Info [528279]
Glycine receptor Target Info Antagonist [543824]
KEGG Pathway Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transportWP2670:Iron uptake and transport
References
Ref 539505(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2366).
Ref 528279Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem. 2006 Jul;98(2):395-407.
Ref 531254Ginkgolide B and bilobalide block the pore of the 5-HT??eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95.
Ref 531440Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Mol Pharmacol. 2011 Jul;80(1):183-90.
Ref 543824(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 427).

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