Drug Information

Drug General Information
Drug ID
D0I4TO
Former ID
DNC010244
Drug Name
(S)-NORDULOXETINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530368]
Structure
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2D MOL

3D MOL
Formula
C17H17NOS
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2OC(CCN)C3=CC=CS3
InChI
1S/C17H17NOS/c18-11-10-16(17-9-4-12-20-17)19-15-8-3-6-13-5-1-2-7-14(13)15/h1-9,12,16H,10-11,18H2/t16-/m0/s1
InChIKey
ZMXLKLOJDLMZFC-INIZCTEOSA-N
PubChem Compound ID
10107888
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [530368]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530368]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530368Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. Epub 2009 Aug 20.Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents fordepression.
Ref 530368Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. Epub 2009 Aug 20.Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents fordepression.

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