Drug Information

Drug General Information
Drug ID
D0IW7O
Former ID
DNC001063
Drug Name
OPC-31260
Drug Type
Small molecular drug
Indication Hyponatraemia [ICD10:E87.1] Approved [544970], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C27H29N3O2
Canonical SMILES
CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43<br />)N(C)C
InChI
1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
InChIKey
WRNXUQJJCIZICJ-UHFFFAOYSA-N
CAS Number
CAS 137975-06-5
PubChem Compound ID
119369
PubChem Substance ID
7980203, 10238465, 14929794, 29300265, 49876628, 50784549, 57339461, 85210057, 85856507, 92251402, 92720235, 103283744, 103938054, 104408167, 118843944, 125340574, 126522418, 126584454, 126620153, 126667663, 129623867, 131298331, 134341821, 135075013, 135650774, 137249480, 142385824, 152035180, 162009841, 162011504, 164826782, 170466304, 172914187, 174527391, 179149887, 206246079, 211535800, 223434818, 223658567, 225355504, 227838631, 241033722, 242059895, 252215844, 252472557
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [534873], [535116], [535608]
Vasopressin V1a receptor Target Info Antagonist [534873]
Vasopressin V1 receptor Target Info Antagonist [535809]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
Vascular smooth muscle contraction
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 544970Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001739)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534873Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65.
Ref 535116Effects of an oral vasopressin receptor antagonist (OPC-31260) in a dog with syndrome of inappropriate secretion of antidiuretic hormone. Aust Vet J. 2000 Dec;78(12):825-30.
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
Ref 535809Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900.

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