Target General Infomation
Target ID
T29999
Former ID
TTDR00176
Target Name
Vasopressin V1 receptor
Synonyms
ADH V1 receptor
Target Type
Successful
Disease Amnesia [ICD10: F04]
Cardiotonic [ICD10: I50]
Hyponatraemia [ICD10: E87.1]
Drugs and Mode of Action
Drug(s) Lypressin Drug Info Approved Amnesia [539375], [551871]
OPC-31260 Drug Info Approved Hyponatraemia [544970], [551871]
OPC-21268 Drug Info Discontinued in Phase 2 Cardiotonic [539395], [544608]
Modulator Lypressin Drug Info [533471], [551871]
Antagonist OPC-21268 Drug Info [535809]
OPC-31260 Drug Info [535809]
Agonist Triglycyl-lysine-vasopressin Drug Info [537975]
References
Ref 539375(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2172).
Ref 539395(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2196).
Ref 544608Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000284)
Ref 544970Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001739)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533471Human pain thresholds after the application of lypressin, a vasopressin analogue. Pharmacol Toxicol. 1987 Jul;61(1):16-9.
Ref 535809Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900.
Ref 537975Evidence in hyponatremia related to inappropriate secretion of ADH that V1 receptor stimulation contributes to the increase in renal uric acid clearance. J Am Soc Nephrol. 1996 May;7(5):805-10.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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