Drug Information

Drug General Information
Drug ID
D0LR8X
Former ID
DIB020955
Drug Name
SKF-83556
Synonyms
SK-83566; SK&F-83566
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543315]
Structure
Download
2D MOL
Formula
C17H18BrNO
InChI
InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
InChIKey
XFTVOHWWEQGXLS-UHFFFAOYSA-N
PubChem Compound ID
1243
PubChem Substance ID
5491588, 7980611, 8151057, 14777543, 24439588, 26752220, 47365430, 47440497, 47662526, 48110696, 50065403, 57320838, 75926542, 85787620, 103331797, 103808619, 103923120, 104297173, 117388470, 126407033, 129682574, 134223457, 135080025, 135651055, 163209974, 172649051, 179236225, 179447836, 250072303, 252559241
Target and Pathway
Target(s) D(1B) dopamine receptor Target Info Antagonist [529311]
Dopamine D1 receptor Target Info Antagonist [529311]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signaling
References
Ref 543315(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 944).
Ref 529311Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.

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