Drug Information

Drug General Information
Drug ID
D0S9IO
Former ID
DNC008268
Drug Name
N-(2-oxazolemethyl)milnacipran
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529263]
Structure
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2D MOL

3D MOL
Formula
C19H25N3O2
Canonical SMILES
CCN(CC)C(=O)C1(CC1CNCC2=NC=CO2)C3=CC=CC=C3
InChI
1S/C19H25N3O2/c1-3-22(4-2)18(23)19(15-8-6-5-7-9-15)12-16(19)13-20-14-17-21-10-11-24-17/h5-11,16,20H,3-4,12-14H2,1-2H3
InChIKey
NCRFMJNGTNNKEE-UHFFFAOYSA-N
PubChem Compound ID
44454825
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [529263]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [529263]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 529263Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Ref 529263Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.

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