Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZM5W
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| Former ID |
DIB011483
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| Drug Name |
ESUPRONE
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| Synonyms |
LU-43839; Esuprone < Rec INN >; 7-Hydroxy-3,4-dimethyl-2H-1-benzopyran-2-one ethanesulfonate; 7-Hydroxy-3,4-dimethylcoumarin ethanesulfonate
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Discontinued in Phase 2 | [545896] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H14O5S
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| Canonical SMILES |
CCS(=O)(=O)Oc1ccc2C(=C(C)C(=O)Oc2c1)C
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| InChI |
1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3
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| InChIKey |
CHDGAVDQRSPBTA-UHFFFAOYSA-N
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| CAS Number |
CAS 91406-11-0
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Amine oxidase [flavin-containing] A | Target Info | Inhibitor | [534393], [551871] | |
| KEGG Pathway | Glycine, serine and threonine metabolism | ||||
| Arginine and proline metabolism | |||||
| Histidine metabolism | |||||
| Tyrosine metabolism | |||||
| Phenylalanine metabolism | |||||
| Tryptophan metabolism | |||||
| Drug metabolism - cytochrome P450 | |||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Dopaminergic synapse | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Alcoholism | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| References | |||||
| Ref 534393 | MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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