Resistance mutation info of target

Target General Information
Target ID T23036
Target Name Bacterial Staphylococcus aureus Enoyl ACP reductase (fabI) Target Info
Gene Name fabI
Species Staphylococcus aureus
Uniprot ID FABI_STAA8
Sequence MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK [Staphylococcus aureus]
Drug Resistance Mutation and Corresponding Drugs
Ref 532242Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics. J Chemother. 2013 Feb;25(1):32-5.
Mutation Info Missense: M99T
Drugs
Drug Name AFN-1252 Drug Info [555978]
Targeted Disease Staphylococcus aureus infection
Mutation Info Missense: Y147H
Drugs
Drug Name AFN-1252 Drug Info [555978]
Targeted Disease Staphylococcus aureus infection
Reference
Ref 555978Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. doi: 10.1074/jbc.M113.512905. Epub 2013 Nov 4.

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