Target Information

Target General Infomation
Target ID
T25315
Former ID
TTDC00125
Target Name
C-X-C chemokine receptor type 3
Gene Name
CXCR3
Synonyms
CD183 antigen; CKR-L2; CXC-R3; CXCR-3; CXCR3/IP-10; Chemokine receptor CXCR3; Chemokine receptor CXCR3/interferon-inducible protein-10; Interferon-inducible protein 10 receptor; CXCR3
Target Type
Discontinued
Disease Autoimmune diabetes [ICD10: E08-E13]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Inflammatory disorder [ICD code not available]
Psoriatic disorder [ICD9: 696; ICD10: L40]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Function
Isoform 3: Mediates theactivity of CXCL11.
BioChemical Class
GPCR rhodopsin
Target Validation
T25315
UniProt ID
P49682
Sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
Drugs and Mode of Action
Drug(s) T487 Drug Info Discontinued in Phase 2 Psoriatic disorder [549897]
T487 Drug Info Discontinued in Phase 1 Inflammatory disorder [549897]
Antagonist CXCR3 antagonists Drug Info [543922]
CXCR3 antagonists Drug Info [543922]
CXCR3 antagonists Drug Info [543922]
dioscin Drug Info [527495]
hypoglaucin A Drug Info [527495]
kallstroemin D Drug Info [527495]
NBI-74330 Drug Info [536059]
Sch-900875 Drug Info [543922]
T487 Drug Info [536005], [536059]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 549897Clinical pipeline report, company report or official report of ChemoCentryx.
Ref 527495Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Mol Divers. 2005;9(1-3):123-9.
Ref 536005FANCG is phosphorylated at serines 383 and 387 during mitosis. Mol Cell Biol. 2004 Oct;24(19):8576-85.
Ref 536059Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. Epub 2005 Mar 10.
Ref 543922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).

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