Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T98089
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| Former ID |
TTDI01948
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| Target Name |
Deoxycytidine kinase
|
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| Gene Name |
DCK
|
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| Synonyms |
dCK; DCK
|
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| Target Type |
Research
|
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| Disease | Unspecified [ICD code not available] | ||||
| Function |
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
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| BioChemical Class |
Kinase
|
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| UniProt ID | |||||
| EC Number |
EC 2.7.1.74
|
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| Sequence |
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE DFKDKYESLVEKVKEFLSTL |
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| Modulator | LP-661438 | Drug Info | |||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
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